2RJQA

Crystal structure of adamts5 with inhibitor bound
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
292
structure length
292
Chain Sequence
SRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
pubmed doi rcsb
molecule keywords ADAMTS-5
total genus 84
structure length 292
sequence length 292
ec nomenclature ec 3.4.24.-:
pdb deposition date 2007-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00090 TSP_1 Thrombospondin type 1 domain
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
A PF17771 ADAM_CR_2 ADAM cysteine-rich domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2rjqA01
1IABA 1DMTA 1BKCE 1ASTA 1JK3A 3F17A 3LUNA 1HTDA 2JT5A 3RTSA 3USNA 5B5OA 2N8RA 5CUHA 1HFSA 1Z3JA 2JIHA 4IJOA 4DV8A 1PWVA 2OZRA 2V4BA 4GR0A 1BQOA 1XFUA 1MMQA 2WO8A 1BKCI 4WZVA 1G9KA 1CGEA 1OS2A 4JA1A 1USNA 1XUDA 1D5JA 1L6JA 4QKZA 4L6TA 3KMCA 3LIKA 4H82A 4AUOA 2A8HA 1JKYA 1SATA 3CKIA 1GKDA 1ROSA 4JIJA 4XCTA 1G05A 1B8YA 2OXWA 1I73A 2MZIA 3O2XA 4WKIA 3G42A 1CGFA 3HBVP 1A85A 1YQYA 2OVZA 1GKCA 3Q2HA 1XURA 3LMCA 3P24A 3F1AA 2JSDA 2ERPA 2L0RA 3F18A 3DL1A 4GQLA 2X3CA 5I0LA 1PWUA 3EDZA 1K7QA 2XS4A 5I12A 966CA 3LK8A 4I35A 4Q1LA 3U1RA 4JPAA 1XFYA 3KRYA 1QIAA 3LE9A 4PKQA 1J7NA 3UVCA 4XM6A 4WK7A 4AXQA 4PKVA 2MZEA 1ZVXA 3F16A 1K7GA 2WOAA 4XBHA 1OS9A 3ELMA 3KHIA 1CQRA 4PKSA 2TCLA 3HYGA 3HB2P 2W0DA 4JQGA 4JP4A 1RM8A 2J83A 1SMPA 1KUKA 3EHXA 1QICA 4GR3A 3DNGA 2OI0A 1D8MA 1OM6A 2OW0A 5L79A 5I3MA 2I47A 3LGPA 2ERQA 3TVCA 1EUBA 1CGLA 1GO8P 2K9CA 3EDGA 1G49A 1ZP5A 3K7NA 3P1VA 1R1HA 3F19A 4H3XA 4WF6A 1C8TA 4XM7A 2OW1A 2YB9A 1GE6A 3ZUKA 2CKIA 1JAOA 2X3AA 2Y6DA 1K7IA 4A3WA 2DW1A 3TT4A 1XFZA 1UTTA 1DTHA 1BZSA 3LQBA 1QJIA 3E8RA 1OMJA 5BPAA 1R1JA 3LILA 2Y6CA 2DDYA 456CA 3LJTA 3HDAP 2OY4A 4FU4A 3ZXHA 1S4BP 2EROA 3I7IA 1CXVA 1PWPA 3I7GA 2AYKA 4FVLA 1UMSA 3RTTA 5D1SA 1WNIA 1IAAA 2OY2A 1D7XA 4G9LA 4CTHA 1JIWP 2DW0A 2MLSA 4DPEA 4DF9A 4HX3A 4GWNA 3OHLA 1ATLA 2X3BA 1JAPA 1JJ9A 1BIWA 3B2ZA 3GBOA 1KUIA 1AF0A 5B5PA 2OXZA 1I1IP 1O0TA 3WV1A 5CZMA 2Z2DA 3VTGA 5D7WA 1B3DA 2D1NA 1HY7A 1SLNA 3DPEA 2FV9A 1IACA 1UEAA 1C3IA 4R3VA 4PKUA 1RMZA 1BUDA 2AIGP 3HDBA 4IUWA 5I43A 2PJTA 5D1UA 2X7MA 2KRJA 1Q3AA 1H71P 3DWBA 1SLMA 4H84A 5JMYA 1R54A 2W12A 1GXDA 1ZXCA 5I4OA 1JH1A 5H8XA 1G12A 3EDIA 1FLSA 1Y8JA 1AKLA 1GE7A 4ON1A 4GUYA 4L19A 1YOUA 1KUGA 2CLTA 3ZVSA 830CA 1HFCA 1GE5A 1FBLA 1XFWA 1UTZA 2K2GA 3KMEA 2JT6A 1JANA 1MMRA 5L7FA 1A86A 4L63A 4GR8A 3EHYA 3F15A 1UMTA 3Q2GA 3LJZA 5D1TA 1Y93A 1IAEA 2YIGA 2POJA 4PKRA 1QUAA 3O64A 3BA0A 1BM6A 1ZXVA 1EB6A 1PWWA 2E3XA 3DPFA 1OM7A 2W13A 1CAQA 2O36A 3LUMA 1CK7A 3N2VA 4H30A 4IN9A 3SHIA 1OO9A 1FM1A 1D8FA 1XFVA 1KUFA 1YP1A 4ILWD 3B8ZA 4AYKA 5BOYA 4WKEA 3L0VA 4H49A 2J0TA 1ND1A 4FXYP 5CXAA 1XFXA 1QJJA 3OHOA 3LKAA 4I03A 2OVXA 1YCMA 3NX7A 1MNCA 1C7KA 2RJPA 4H2EA 1R55A 1GO7P 1IAGA 1BKCA 2W15A 2QPJA 3KWVC 1MMBA 3HY9A 4AIGA 3LQ0A 1KUHA 3VI1A 3EDHA 1JAQA 4PKWA 1BQQM 3KEKA 3EWJA 1XUCA 4G0DA 4J4MA 4ZR5A 2E2DA 3TS4A 3B92A 4HMAA 2MZHA 3G5CA 2HU6A 3LEAA 3WV3A 1HOVA 1OM8A 5I2ZA 2WO9A 1JIZA 2OW2A 1SRPA 1Y0VA 3AYKA 1ZS0A 2W14A 2MLRA 1EAKA 2SRTA 4GWMA 2DW2A 3N2UA 4FXQA 2XS3A 1O0QA 1PWQA 3HY7A 3MA2A 2RJQA 1QIBA 3TSKA 1SU3A 4A7BA 1R1IA 1G4KA 1CIZA 1KAPP 2DDFA 3LJGA 1I76A 2D1OA 2JNPA 3V96B 4H76A 5BOTA 2FV5A 4DD8A 3LIRA 3HBUP 1BUVM 4EFSA 4H1QA 2O3EA 1IADA 1MMPA 3KEJA 4XM8A 1KBCA 3DSLA 2USNA 3WV2A 1ZTQA 4GF1A 1AYKA 1HV5A 3AIGA 2OXUA 5LABA 2OW9A 5D2BA 5D3CA 3AYUA 3K7LA 3L0TA 3KECA 4PKTA 1BSWA
chains in the Genus database with same CATH superfamily
1IABA 1DMTA 1BKCE 1ASTA 1JK3A 3F17A 3LUNA 1HTDA 2JT5A 3RTSA 3USNA 5B5OA 2N8RA 5CUHA 1HFSA 1Z3JA 2JIHA 4IJOA 4DV8A 1PWVA 2OZRA 2V4BA 4GR0A 1BQOA 1XFUA 1MMQA 2WO8A 1BKCI 4WZVA 2YUFA 1G9KA 1CGEA 1OS2A 4JA1A 1USNA 1XUDA 1D5JA 1L6JA 4QKZA 4L6TA 3KMCA 3LIKA 4H82A 4AUOA 2A8HA 1JKYA 1SATA 3CKIA 1GKDA 1ROSA 4JIJA 4XCTA 1G05A 1B8YA 2OXWA 1I73A 1XAXA 2MZIA 3O2XA 4WKIA 3G42A 1CGFA 3HBVP 1A85A 1YQYA 2OVZA 1GKCA 3Q2HA 1XURA 3LMCA 3P24A 3F1AA 2JSDA 2ERPA 2L0RA 3F18A 3DL1A 4GQLA 2X3CA 5I0LA 1PWUA 3EDZA 1K7QA 2XS4A 5I12A 966CA 3LK8A 4I35A 4Q1LA 3U1RA 4JPAA 1XFYA 3KRYA 1QIAA 3LE9A 4PKQA 1J7NA 3UVCA 4XM6A 4WK7A 4AXQA 4PKVA 2MZEA 1ZVXA 3F16A 1K7GA 2WOAA 4XBHA 1OS9A 3ELMA 3KHIA 1CQRA 4PKSA 2TCLA 3HYGA 3HB2P 2W0DA 4JQGA 4JP4A 1RM8A 2J83A 1SMPA 1KUKA 3EHXA 1OZ9A 1QICA 4GR3A 3DNGA 2OI0A 1D8MA 1OM6A 2OW0A 5L79A 5I3MA 2I47A 3LGPA 2ERQA 3TVCA 1EUBA 1CGLA 1GO8P 2K9CA 3EDGA 1G49A 1ZP5A 3K7NA 3P1VA 1R1HA 3F19A 4H3XA 4WF6A 1C8TA 4XM7A 2OW1A 2YB9A 1GE6A 3ZUKA 2CKIA 1JAOA 2X3AA 2Y6DA 1K7IA 4A3WA 2DW1A 3TT4A 1XFZA 1UTTA 1DTHA 1BZSA 3LQBA 1QJIA 3E8RA 1OMJA 5BPAA 1R1JA 3LILA 2Y6CA 2DDYA 456CA 3LJTA 3HDAP 2OY4A 4FU4A 3ZXHA 1S4BP 2EROA 3I7IA 1CXVA 1PWPA 3I7GA 2AYKA 4FVLA 1UMSA 3RTTA 5D1SA 1WNIA 1IAAA 2OY2A 1D7XA 4G9LA 4CTHA 1JIWP 2DW0A 2MLSA 4DPEA 4DF9A 4HX3A 4GWNA 3OHLA 1ATLA 2X3BA 1JAPA 1JJ9A 1BIWA 3B2ZA 3GBOA 1KUIA 1AF0A 5B5PA 2OXZA 1I1IP 1O0TA 3WV1A 5CZMA 2Z2DA 3VTGA 5D7WA 1B3DA 2D1NA 1HY7A 1SLNA 3DPEA 2FV9A 1IACA 1UEAA 1C3IA 4R3VA 4PKUA 1RMZA 1BUDA 2AIGP 3HDBA 4IUWA 5I43A 2PJTA 5D1UA 2X7MA 2KRJA 1Q3AA 1H71P 3DWBA 1SLMA 4H84A 5JMYA 1R54A 2W12A 1GXDA 1ZXCA 5I4OA 1JH1A 5H8XA 1G12A 3EDIA 1FLSA 1Y8JA 1AKLA 1GE7A 4ON1A 4GUYA 4L19A 1YOUA 1KUGA 2CLTA 3ZVSA 830CA 1HFCA 1GE5A 1FBLA 1XFWA 1UTZA 2K2GA 3KMEA 2JT6A 1JANA 1MMRA 5L7FA 1A86A 4L63A 4GR8A 3EHYA 3F15A 1UMTA 3Q2GA 3LJZA 5D1TA 1Y93A 1IAEA 2YIGA 2POJA 4PKRA 1QUAA 3O64A 3BA0A 1BM6A 1ZXVA 1EB6A 1PWWA 3DTIA 2E3XA 3DPFA 1OM7A 2W13A 1CAQA 2O36A 3LUMA 1CK7A 3N2VA 4H30A 4IN9A 3SHIA 1OO9A 1FM1A 1D8FA 1XFVA 1KUFA 1YP1A 3DTEA 4ILWD 3B8ZA 4AYKA 5BOYA 4WKEA 1TVIA 3L0VA 4H49A 2J0TA 1ND1A 4L7AA 4FXYP 5CXAA 1XFXA 1QJJA 3OHOA 3LKAA 4I03A 2OVXA 1YCMA 3NX7A 1MNCA 1C7KA 2RJPA 4H2EA 1R55A 1GO7P 1IAGA 1BKCA 2W15A 2QPJA 3KWVC 1MMBA 3HY9A 4AIGA 3LQ0A 1KUHA 3VI1A 3EDHA 1JAQA 4PKWA 1BQQM 3KEKA 3EWJA 1XUCA 4G0DA 4J4MA 4ZR5A 2E2DA 3TS4A 3B92A 4HMAA 2MZHA 3G5CA 2HU6A 3LEAA 3WV3A 1HOVA 1OM8A 5I2ZA 2WO9A 1JIZA 3DTKA 2OW2A 1SRPA 1Y0VA 3AYKA 1ZS0A 2W14A 2MLRA 1EAKA 2SRTA 4GWMA 2DW2A 3N2UA 4FXQA 2XS3A 1O0QA 1PWQA 3HY7A 3MA2A 2RJQA 1QIBA 3TSKA 1SU3A 4A7BA 1R1IA 1G4KA 1CIZA 1KAPP 2DDFA 3LJGA 1I76A 2D1OA 2JNPA 3V96B 4H76A 5BOTA 2FV5A 4DD8A 3LIRA 1XM5A 3HBUP 1BUVM 4EFSA 4H1QA 2O3EA 1IADA 1MMPA 3KEJA 4XM8A 1KBCA 3DSLA 2USNA 3WV2A 1ZTQA 4GF1A 1AYKA 1HV5A 3AIGA 2OXUA 5LABA 2OW9A 5D2BA 5D3CA 3AYUA 3K7LA 3L0TA 3KECA 4PKTA 1BSWA
chains in the Genus database with same CATH topology
1IABA 1DMTA 1BKCE 1ASTA 1JK3A 3F17A 3LUNA 1HTDA 2JT5A 3RTSA 3USNA 5B5OA 2N8RA 5CUHA 1HFSA 1Z3JA 2JIHA 4IJOA 4DV8A 1PWVA 2OZRA 2V4BA 4GR0A 1BQOA 1XFUA 1MMQA 2WO8A 1BKCI 4WZVA 2YUFA 1G9KA 1CGEA 1OS2A 4JA1A 1USNA 1XUDA 1D5JA 1L6JA 4QKZA 4L6TA 3KMCA 3LIKA 4H82A 4AUOA 2A8HA 1JKYA 1SATA 3CKIA 1GKDA 1ROSA 4JIJA 4XCTA 1G05A 1B8YA 2OXWA 1I73A 2MZIA 3O2XA 4WKIA 3G42A 1CGFA 3HBVP 1A85A 1YQYA 2OVZA 1GKCA 3Q2HA 1XURA 3LMCA 3P24A 3F1AA 2JSDA 2ERPA 2L0RA 3F18A 3DL1A 4GQLA 2X3CA 5I0LA 1PWUA 3EDZA 1K7QA 2XS4A 5I12A 966CA 3LK8A 4I35A 4Q1LA 3U1RA 4JPAA 1XFYA 3KRYA 1QIAA 3LE9A 4PKQA 1J7NA 3UVCA 4XM6A 4WK7A 4AXQA 4PKVA 2MZEA 1ZVXA 3F16A 1K7GA 2WOAA 4XBHA 1OS9A 3ELMA 3KHIA 1CQRA 4PKSA 2TCLA 3HYGA 3HB2P 2W0DA 4JQGA 4JP4A 1RM8A 2J83A 1SMPA 1KUKA 3EHXA 1QICA 4GR3A 3DNGA 2OI0A 1D8MA 1OM6A 2OW0A 5L79A 5I3MA 2I47A 3LGPA 2ERQA 3TVCA 1EUBA 1CGLA 1GO8P 2K9CA 3EDGA 1G49A 1ZP5A 3K7NA 3P1VA 1R1HA 3F19A 4H3XA 4WF6A 1C8TA 4XM7A 2OW1A 2YB9A 1GE6A 3ZUKA 2CKIA 1JAOA 2X3AA 2Y6DA 1K7IA 4A3WA 2DW1A 3TT4A 1XFZA 1UTTA 1DTHA 1BZSA 3LQBA 1QJIA 3E8RA 1OMJA 5BPAA 1R1JA 3LILA 2Y6CA 2DDYA 456CA 3LJTA 3HDAP 2OY4A 4FU4A 3ZXHA 1S4BP 2EROA 3I7IA 1CXVA 1PWPA 3I7GA 2AYKA 4FVLA 1UMSA 3RTTA 5D1SA 1WNIA 1IAAA 2OY2A 1D7XA 4G9LA 4CTHA 1JIWP 2DW0A 2MLSA 4DPEA 4DF9A 4HX3A 4GWNA 3OHLA 1ATLA 2X3BA 1JAPA 1JJ9A 1BIWA 3B2ZA 3GBOA 1KUIA 1AF0A 5B5PA 2OXZA 1I1IP 1O0TA 3WV1A 5CZMA 2Z2DA 3VTGA 5D7WA 1B3DA 2D1NA 1HY7A 1SLNA 3DPEA 2FV9A 1IACA 1UEAA 1C3IA 4R3VA 4PKUA 1RMZA 1BUDA 2AIGP 3HDBA 4IUWA 5I43A 2PJTA 5D1UA 2X7MA 2KRJA 1Q3AA 1H71P 3DWBA 1SLMA 4H84A 5JMYA 1R54A 2W12A 1GXDA 1ZXCA 5I4OA 1JH1A 5H8XA 1G12A 3EDIA 1FLSA 1Y8JA 1AKLA 1GE7A 4ON1A 4GUYA 4L19A 1YOUA 1KUGA 2CLTA 3ZVSA 830CA 1HFCA 1GE5A 1FBLA 1XFWA 1UTZA 2K2GA 3KMEA 2JT6A 1JANA 1MMRA 5L7FA 1A86A 4L63A 4GR8A 3EHYA 3F15A 1UMTA 3Q2GA 3LJZA 5D1TA 1Y93A 1IAEA 2YIGA 2POJA 4PKRA 1QUAA 3O64A 3BA0A 1BM6A 1ZXVA 1EB6A 1PWWA 3DTIA 2E3XA 3DPFA 1OM7A 2W13A 1CAQA 2O36A 3LUMA 1CK7A 3N2VA 4H30A 4IN9A 3SHIA 1OO9A 1FM1A 1D8FA 1XFVA 1KUFA 1YP1A 3DTEA 4ILWD 3B8ZA 4AYKA 5BOYA 4WKEA 3L0VA 4H49A 2J0TA 1ND1A 4L7AA 4FXYP 5CXAA 1XFXA 1QJJA 3OHOA 3LKAA 4I03A 2OVXA 1YCMA 3NX7A 1MNCA 1C7KA 2RJPA 4H2EA 1R55A 1GO7P 1IAGA 1BKCA 2W15A 2QPJA 3KWVC 1MMBA 3HY9A 4AIGA 3LQ0A 1KUHA 3VI1A 3EDHA 1JAQA 4PKWA 1BQQM 3KEKA 3EWJA 1XUCA 4G0DA 4J4MA 4ZR5A 2E2DA 3TS4A 3B92A 4HMAA 2MZHA 3G5CA 2HU6A 3LEAA 3WV3A 1HOVA 1OM8A 5I2ZA 2WO9A 1JIZA 3DTKA 2OW2A 1SRPA 1Y0VA 3AYKA 1ZS0A 2W14A 2MLRA 1EAKA 2SRTA 4GWMA 2DW2A 3N2UA 4FXQA 2XS3A 1O0QA 1PWQA 3HY7A 3MA2A 2RJQA 1QIBA 3TSKA 1SU3A 4A7BA 1R1IA 1G4KA 1CIZA 1KAPP 2DDFA 3LJGA 1I76A 2D1OA 2JNPA 3V96B 4H76A 5BOTA 2FV5A 4DD8A 3LIRA 3HBUP 1BUVM 4EFSA 4H1QA 2O3EA 1IADA 1MMPA 3KEJA 4XM8A 1KBCA 3DSLA 2USNA 3WV2A 1ZTQA 4GF1A 1AYKA 1HV5A 3AIGA 2OXUA 5LABA 2OW9A 5D2BA 5D3CA 3AYUA 3K7LA 3L0TA 3KECA 4PKTA 1BSWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IAB A;  1DMT A;  1BKC E;  1AST A;  1JK3 A;  3F17 A;  3LUN A;  1HTD A;  2JT5 A;  3RTS A;  3USN A;  5B5O A;  2N8R A;  5CUH A;  1HFS A;  1Z3J A;  2JIH A;  4IJO A;  4DV8 A;  1PWV A;  2OZR A;  2V4B A;  4GR0 A;  1BQO A;  1XFU A;  1MMQ A;  2WO8 A;  1BKC I;  4WZV A;  1G9K A;  1CGE A;  1OS2 A;  4JA1 A;  1USN A;  1XUD A;  1D5J A;  1L6J A;  4QKZ A;  4L6T A;  3KMC A;  3LIK A;  4H82 A;  4AUO A;  2A8H A;  1JKY A;  1SAT A;  3CKI A;  1GKD A;  1ROS A;  4JIJ A;  4XCT A;  1G05 A;  1B8Y A;  2OXW A;  1I73 A;  2MZI A;  3O2X A;  4WKI A;  3G42 A;  1CGF A;  3HBV P;  1A85 A;  1YQY A;  2OVZ A;  1GKC A;  3Q2H A;  1XUR A;  3LMC A;  3P24 A;  3F1A A;  2JSD A;  2ERP A;  2L0R A;  3F18 A;  3DL1 A;  4GQL A;  2X3C A;  5I0L A;  1PWU A;  3EDZ A;  1K7Q A;  2XS4 A;  5I12 A;  966C A;  3LK8 A;  4I35 A;  4Q1L A;  3U1R A;  4JPA A;  1XFY A;  3KRY A;  1QIA A;  3LE9 A;  4PKQ A;  1J7N A;  3UVC A;  4XM6 A;  4WK7 A;  4AXQ A;  4PKV A;  2MZE A;  1ZVX A;  3F16 A;  1K7G A;  2WOA A;  4XBH A;  1OS9 A;  3ELM A;  3KHI A;  1CQR A;  4PKS A;  2TCL A;  3HYG A;  3HB2 P;  2W0D A;  4JQG A;  4JP4 A;  1RM8 A;  2J83 A;  1SMP A;  1KUK A;  3EHX A;  1QIC A;  4GR3 A;  3DNG A;  2OI0 A;  1D8M A;  1OM6 A;  2OW0 A;  5L79 A;  5I3M A;  2I47 A;  3LGP A;  2ERQ A;  3TVC A;  1EUB A;  1CGL A;  1GO8 P;  2K9C A;  3EDG A;  1G49 A;  1ZP5 A;  3K7N A;  3P1V A;  1R1H A;  3F19 A;  4H3X A;  4WF6 A;  1C8T A;  4XM7 A;  2OW1 A;  2YB9 A;  1GE6 A;  3ZUK A;  2CKI A;  1JAO A;  2X3A A;  2Y6D A;  1K7I A;  4A3W A;  2DW1 A;  3TT4 A;  1XFZ A;  1UTT A;  1DTH A;  1BZS A;  3LQB A;  1QJI A;  3E8R A;  1OMJ A;  5BPA A;  1R1J A;  3LIL A;  2Y6C A;  2DDY A;  456C A;  3LJT A;  3HDA P;  2OY4 A;  4FU4 A;  3ZXH A;  1S4B P;  2ERO A;  3I7I A;  1CXV A;  1PWP A;  3I7G A;  2AYK A;  4FVL A;  1UMS A;  3RTT A;  5D1S A;  1WNI A;  1IAA A;  2OY2 A;  1D7X A;  4G9L A;  4CTH A;  1JIW P;  2DW0 A;  2MLS A;  4DPE A;  4DF9 A;  4HX3 A;  4GWN A;  3OHL A;  1ATL A;  2X3B A;  1JAP A;  1JJ9 A;  1BIW A;  3B2Z A;  3GBO A;  1KUI A;  1AF0 A;  5B5P A;  2OXZ A;  1I1I P;  1O0T A;  3WV1 A;  5CZM A;  2Z2D A;  3VTG A;  5D7W A;  1B3D A;  2D1N A;  1HY7 A;  1SLN A;  3DPE A;  2FV9 A;  1IAC A;  1UEA A;  1C3I A;  4R3V A;  4PKU A;  1RMZ A;  1BUD A;  2AIG P;  3HDB A;  4IUW A;  5I43 A;  2PJT A;  5D1U A;  2X7M A;  2KRJ A;  1Q3A A;  1H71 P;  3DWB A;  1SLM A;  4H84 A;  5JMY A;  1R54 A;  2W12 A;  1GXD A;  1ZXC A;  5I4O A;  1JH1 A;  5H8X A;  1G12 A;  3EDI A;  1FLS A;  1Y8J A;  1AKL A;  1GE7 A;  4ON1 A;  4GUY A;  4L19 A;  1YOU A;  1KUG A;  2CLT A;  3ZVS A;  830C A;  1HFC A;  1GE5 A;  1FBL A;  1XFW A;  1UTZ A;  2K2G A;  3KME A;  2JT6 A;  1JAN A;  1MMR A;  5L7F A;  1A86 A;  4L63 A;  4GR8 A;  3EHY A;  3F15 A;  1UMT A;  3Q2G A;  3LJZ A;  5D1T A;  1Y93 A;  1IAE A;  2YIG A;  2POJ A;  4PKR A;  1QUA A;  3O64 A;  3BA0 A;  1BM6 A;  1ZXV A;  1EB6 A;  1PWW A;  2E3X A;  3DPF A;  1OM7 A;  2W13 A;  1CAQ A;  2O36 A;  3LUM A;  1CK7 A;  3N2V A;  4H30 A;  4IN9 A;  3SHI A;  1OO9 A;  1FM1 A;  1D8F A;  1XFV A;  1KUF A;  1YP1 A;  4ILW D;  3B8Z A;  4AYK A;  5BOY A;  4WKE A;  3L0V A;  4H49 A;  2J0T A;  1ND1 A;  4FXY P;  5CXA A;  1XFX A;  1QJJ A;  3OHO A;  3LKA A;  4I03 A;  2OVX A;  1YCM A;  3NX7 A;  1MNC A;  1C7K A;  2RJP A;  4H2E A;  1R55 A;  1GO7 P;  1IAG A;  1BKC A;  2W15 A;  2QPJ A;  3KWV C;  1MMB A;  3HY9 A;  4AIG A;  3LQ0 A;  1KUH A;  3VI1 A;  3EDH A;  1JAQ A;  4PKW A;  1BQQ M;  3KEK A;  3EWJ A;  1XUC A;  4G0D A;  4J4M A;  4ZR5 A;  2E2D A;  3TS4 A;  3B92 A;  4HMA A;  2MZH A;  3G5C A;  2HU6 A;  3LEA A;  3WV3 A;  1HOV A;  1OM8 A;  5I2Z A;  2WO9 A;  1JIZ A;  2OW2 A;  1SRP A;  1Y0V A;  3AYK A;  1ZS0 A;  2W14 A;  2MLR A;  1EAK A;  2SRT A;  4GWM A;  2DW2 A;  3N2U A;  4FXQ A;  2XS3 A;  1O0Q A;  1PWQ A;  3HY7 A;  3MA2 A;  2RJQ A;  1QIB A;  3TSK A;  1SU3 A;  4A7B A;  1R1I A;  1G4K A;  1CIZ A;  1KAP P;  2DDF A;  3LJG A;  1I76 A;  2D1O A;  2JNP A;  3V96 B;  4H76 A;  5BOT A;  2FV5 A;  4DD8 A;  3LIR A;  3HBU P;  1BUV M;  4EFS A;  4H1Q A;  2O3E A;  1IAD A;  1MMP A;  3KEJ A;  4XM8 A;  1KBC A;  3DSL A;  2USN A;  3WV2 A;  1ZTQ A;  4GF1 A;  1AYK A;  1HV5 A;  3AIG A;  2OXU A;  5LAB A;  2OW9 A;  5D2B A;  5D3C A;  3AYU A;  3K7L A;  3L0T A;  3KEC A;  4PKT A;  1BSW A; 
#chains in the Genus database with same CATH topology
 1IAB A;  1DMT A;  1BKC E;  1AST A;  1JK3 A;  3F17 A;  3LUN A;  1HTD A;  2JT5 A;  3RTS A;  3USN A;  5B5O A;  2N8R A;  5CUH A;  1HFS A;  1Z3J A;  2JIH A;  4IJO A;  4DV8 A;  1PWV A;  2OZR A;  2V4B A;  4GR0 A;  1BQO A;  1XFU A;  1MMQ A;  2WO8 A;  1BKC I;  4WZV A;  2YUF A;  1G9K A;  1CGE A;  1OS2 A;  4JA1 A;  1USN A;  1XUD A;  1D5J A;  1L6J A;  4QKZ A;  4L6T A;  3KMC A;  3LIK A;  4H82 A;  4AUO A;  2A8H A;  1JKY A;  1SAT A;  3CKI A;  1GKD A;  1ROS A;  4JIJ A;  4XCT A;  1G05 A;  1B8Y A;  2OXW A;  1I73 A;  1XAX A;  2MZI A;  3O2X A;  4WKI A;  3G42 A;  1CGF A;  3HBV P;  1A85 A;  1YQY A;  2OVZ A;  1GKC A;  3Q2H A;  1XUR A;  3LMC A;  3P24 A;  3F1A A;  2JSD A;  2ERP A;  2L0R A;  3F18 A;  3DL1 A;  4GQL A;  2X3C A;  5I0L A;  1PWU A;  3EDZ A;  1K7Q A;  2XS4 A;  5I12 A;  966C A;  3LK8 A;  4I35 A;  4Q1L A;  3U1R A;  4JPA A;  1XFY A;  3KRY A;  1QIA A;  3LE9 A;  4PKQ A;  1J7N A;  3UVC A;  4XM6 A;  4WK7 A;  4AXQ A;  4PKV A;  2MZE A;  1ZVX A;  3F16 A;  1K7G A;  2WOA A;  4XBH A;  1OS9 A;  3ELM A;  3KHI A;  1CQR A;  4PKS A;  2TCL A;  3HYG A;  3HB2 P;  2W0D A;  4JQG A;  4JP4 A;  1RM8 A;  2J83 A;  1SMP A;  1KUK A;  3EHX A;  1OZ9 A;  1QIC A;  4GR3 A;  3DNG A;  2OI0 A;  1D8M A;  1OM6 A;  2OW0 A;  5L79 A;  5I3M A;  2I47 A;  3LGP A;  2ERQ A;  3TVC A;  1EUB A;  1CGL A;  1GO8 P;  2K9C A;  3EDG A;  1G49 A;  1ZP5 A;  3K7N A;  3P1V A;  1R1H A;  3F19 A;  4H3X A;  4WF6 A;  1C8T A;  4XM7 A;  2OW1 A;  2YB9 A;  1GE6 A;  3ZUK A;  2CKI A;  1JAO A;  2X3A A;  2Y6D A;  1K7I A;  4A3W A;  2DW1 A;  3TT4 A;  1XFZ A;  1UTT A;  1DTH A;  1BZS A;  3LQB A;  1QJI A;  3E8R A;  1OMJ A;  5BPA A;  1R1J A;  3LIL A;  2Y6C A;  2DDY A;  456C A;  3LJT A;  3HDA P;  2OY4 A;  4FU4 A;  3ZXH A;  1S4B P;  2ERO A;  3I7I A;  1CXV A;  1PWP A;  3I7G A;  2AYK A;  4FVL A;  1UMS A;  3RTT A;  5D1S A;  1WNI A;  1IAA A;  2OY2 A;  1D7X A;  4G9L A;  4CTH A;  1JIW P;  2DW0 A;  2MLS A;  4DPE A;  4DF9 A;  4HX3 A;  4GWN A;  3OHL A;  1ATL A;  2X3B A;  1JAP A;  1JJ9 A;  1BIW A;  3B2Z A;  3GBO A;  1KUI A;  1AF0 A;  5B5P A;  2OXZ A;  1I1I P;  1O0T A;  3WV1 A;  5CZM A;  2Z2D A;  3VTG A;  5D7W A;  1B3D A;  2D1N A;  1HY7 A;  1SLN A;  3DPE A;  2FV9 A;  1IAC A;  1UEA A;  1C3I A;  4R3V A;  4PKU A;  1RMZ A;  1BUD A;  2AIG P;  3HDB A;  4IUW A;  5I43 A;  2PJT A;  5D1U A;  2X7M A;  2KRJ A;  1Q3A A;  1H71 P;  3DWB A;  1SLM A;  4H84 A;  5JMY A;  1R54 A;  2W12 A;  1GXD A;  1ZXC A;  5I4O A;  1JH1 A;  5H8X A;  1G12 A;  3EDI A;  1FLS A;  1Y8J A;  1AKL A;  1GE7 A;  4ON1 A;  4GUY A;  4L19 A;  1YOU A;  1KUG A;  2CLT A;  3ZVS A;  830C A;  1HFC A;  1GE5 A;  1FBL A;  1XFW A;  1UTZ A;  2K2G A;  3KME A;  2JT6 A;  1JAN A;  1MMR A;  5L7F A;  1A86 A;  4L63 A;  4GR8 A;  3EHY A;  3F15 A;  1UMT A;  3Q2G A;  3LJZ A;  5D1T A;  1Y93 A;  1IAE A;  2YIG A;  2POJ A;  4PKR A;  1QUA A;  3O64 A;  3BA0 A;  1BM6 A;  1ZXV A;  1EB6 A;  1PWW A;  3DTI A;  2E3X A;  3DPF A;  1OM7 A;  2W13 A;  1CAQ A;  2O36 A;  3LUM A;  1CK7 A;  3N2V A;  4H30 A;  4IN9 A;  3SHI A;  1OO9 A;  1FM1 A;  1D8F A;  1XFV A;  1KUF A;  1YP1 A;  3DTE A;  4ILW D;  3B8Z A;  4AYK A;  5BOY A;  4WKE A;  1TVI A;  3L0V A;  4H49 A;  2J0T A;  1ND1 A;  4L7A A;  4FXY P;  5CXA A;  1XFX A;  1QJJ A;  3OHO A;  3LKA A;  4I03 A;  2OVX A;  1YCM A;  3NX7 A;  1MNC A;  1C7K A;  2RJP A;  4H2E A;  1R55 A;  1GO7 P;  1IAG A;  1BKC A;  2W15 A;  2QPJ A;  3KWV C;  1MMB A;  3HY9 A;  4AIG A;  3LQ0 A;  1KUH A;  3VI1 A;  3EDH A;  1JAQ A;  4PKW A;  1BQQ M;  3KEK A;  3EWJ A;  1XUC A;  4G0D A;  4J4M A;  4ZR5 A;  2E2D A;  3TS4 A;  3B92 A;  4HMA A;  2MZH A;  3G5C A;  2HU6 A;  3LEA A;  3WV3 A;  1HOV A;  1OM8 A;  5I2Z A;  2WO9 A;  1JIZ A;  3DTK A;  2OW2 A;  1SRP A;  1Y0V A;  3AYK A;  1ZS0 A;  2W14 A;  2MLR A;  1EAK A;  2SRT A;  4GWM A;  2DW2 A;  3N2U A;  4FXQ A;  2XS3 A;  1O0Q A;  1PWQ A;  3HY7 A;  3MA2 A;  2RJQ A;  1QIB A;  3TSK A;  1SU3 A;  4A7B A;  1R1I A;  1G4K A;  1CIZ A;  1KAP P;  2DDF A;  3LJG A;  1I76 A;  2D1O A;  2JNP A;  3V96 B;  4H76 A;  5BOT A;  2FV5 A;  4DD8 A;  3LIR A;  1XM5 A;  3HBU P;  1BUV M;  4EFS A;  4H1Q A;  2O3E A;  1IAD A;  1MMP A;  3KEJ A;  4XM8 A;  1KBC A;  3DSL A;  2USN A;  3WV2 A;  1ZTQ A;  4GF1 A;  1AYK A;  1HV5 A;  3AIG A;  2OXU A;  5LAB A;  2OW9 A;  5D2B A;  5D3C A;  3AYU A;  3K7L A;  3L0T A;  3KEC A;  4PKT A;  1BSW A; 
#chains in the Genus database with same CATH homology
 1IAB A;  1DMT A;  1BKC E;  1AST A;  1JK3 A;  3F17 A;  3LUN A;  1HTD A;  2JT5 A;  3RTS A;  3USN A;  5B5O A;  2N8R A;  5CUH A;  1HFS A;  1Z3J A;  2JIH A;  4IJO A;  4DV8 A;  1PWV A;  2OZR A;  2V4B A;  4GR0 A;  1BQO A;  1XFU A;  1MMQ A;  2WO8 A;  1BKC I;  4WZV A;  2YUF A;  1G9K A;  1CGE A;  1OS2 A;  4JA1 A;  1USN A;  1XUD A;  1D5J A;  1L6J A;  4QKZ A;  4L6T A;  3KMC A;  3LIK A;  4H82 A;  4AUO A;  2A8H A;  1JKY A;  1SAT A;  3CKI A;  1GKD A;  1ROS A;  4JIJ A;  4XCT A;  1G05 A;  1B8Y A;  2OXW A;  1I73 A;  2MZI A;  3O2X A;  4WKI A;  3G42 A;  1CGF A;  3HBV P;  1A85 A;  1YQY A;  2OVZ A;  1GKC A;  3Q2H A;  1XUR A;  3LMC A;  3P24 A;  3F1A A;  2JSD A;  2ERP A;  2L0R A;  3F18 A;  3DL1 A;  4GQL A;  2X3C A;  5I0L A;  1PWU A;  3EDZ A;  1K7Q A;  2XS4 A;  5I12 A;  966C A;  3LK8 A;  4I35 A;  4Q1L A;  3U1R A;  4JPA A;  1XFY A;  3KRY A;  1QIA A;  3LE9 A;  4PKQ A;  1J7N A;  3UVC A;  4XM6 A;  4WK7 A;  4AXQ A;  4PKV A;  2MZE A;  1ZVX A;  3F16 A;  1K7G A;  2WOA A;  4XBH A;  1OS9 A;  3ELM A;  3KHI A;  1CQR A;  4PKS A;  2TCL A;  3HYG A;  3HB2 P;  2W0D A;  4JQG A;  4JP4 A;  1RM8 A;  2J83 A;  1SMP A;  1KUK A;  3EHX A;  1QIC A;  4GR3 A;  3DNG A;  2OI0 A;  1D8M A;  1OM6 A;  2OW0 A;  5L79 A;  5I3M A;  2I47 A;  3LGP A;  2ERQ A;  3TVC A;  1EUB A;  1CGL A;  1GO8 P;  2K9C A;  3EDG A;  1G49 A;  1ZP5 A;  3K7N A;  3P1V A;  1R1H A;  3F19 A;  4H3X A;  4WF6 A;  1C8T A;  4XM7 A;  2OW1 A;  2YB9 A;  1GE6 A;  3ZUK A;  2CKI A;  1JAO A;  2X3A A;  2Y6D A;  1K7I A;  4A3W A;  2DW1 A;  3TT4 A;  1XFZ A;  1UTT A;  1DTH A;  1BZS A;  3LQB A;  1QJI A;  3E8R A;  1OMJ A;  5BPA A;  1R1J A;  3LIL A;  2Y6C A;  2DDY A;  456C A;  3LJT A;  3HDA P;  2OY4 A;  4FU4 A;  3ZXH A;  1S4B P;  2ERO A;  3I7I A;  1CXV A;  1PWP A;  3I7G A;  2AYK A;  4FVL A;  1UMS A;  3RTT A;  5D1S A;  1WNI A;  1IAA A;  2OY2 A;  1D7X A;  4G9L A;  4CTH A;  1JIW P;  2DW0 A;  2MLS A;  4DPE A;  4DF9 A;  4HX3 A;  4GWN A;  3OHL A;  1ATL A;  2X3B A;  1JAP A;  1JJ9 A;  1BIW A;  3B2Z A;  3GBO A;  1KUI A;  1AF0 A;  5B5P A;  2OXZ A;  1I1I P;  1O0T A;  3WV1 A;  5CZM A;  2Z2D A;  3VTG A;  5D7W A;  1B3D A;  2D1N A;  1HY7 A;  1SLN A;  3DPE A;  2FV9 A;  1IAC A;  1UEA A;  1C3I A;  4R3V A;  4PKU A;  1RMZ A;  1BUD A;  2AIG P;  3HDB A;  4IUW A;  5I43 A;  2PJT A;  5D1U A;  2X7M A;  2KRJ A;  1Q3A A;  1H71 P;  3DWB A;  1SLM A;  4H84 A;  5JMY A;  1R54 A;  2W12 A;  1GXD A;  1ZXC A;  5I4O A;  1JH1 A;  5H8X A;  1G12 A;  3EDI A;  1FLS A;  1Y8J A;  1AKL A;  1GE7 A;  4ON1 A;  4GUY A;  4L19 A;  1YOU A;  1KUG A;  2CLT A;  3ZVS A;  830C A;  1HFC A;  1GE5 A;  1FBL A;  1XFW A;  1UTZ A;  2K2G A;  3KME A;  2JT6 A;  1JAN A;  1MMR A;  5L7F A;  1A86 A;  4L63 A;  4GR8 A;  3EHY A;  3F15 A;  1UMT A;  3Q2G A;  3LJZ A;  5D1T A;  1Y93 A;  1IAE A;  2YIG A;  2POJ A;  4PKR A;  1QUA A;  3O64 A;  3BA0 A;  1BM6 A;  1ZXV A;  1EB6 A;  1PWW A;  3DTI A;  2E3X A;  3DPF A;  1OM7 A;  2W13 A;  1CAQ A;  2O36 A;  3LUM A;  1CK7 A;  3N2V A;  4H30 A;  4IN9 A;  3SHI A;  1OO9 A;  1FM1 A;  1D8F A;  1XFV A;  1KUF A;  1YP1 A;  3DTE A;  4ILW D;  3B8Z A;  4AYK A;  5BOY A;  4WKE A;  3L0V A;  4H49 A;  2J0T A;  1ND1 A;  4L7A A;  4FXY P;  5CXA A;  1XFX A;  1QJJ A;  3OHO A;  3LKA A;  4I03 A;  2OVX A;  1YCM A;  3NX7 A;  1MNC A;  1C7K A;  2RJP A;  4H2E A;  1R55 A;  1GO7 P;  1IAG A;  1BKC A;  2W15 A;  2QPJ A;  3KWV C;  1MMB A;  3HY9 A;  4AIG A;  3LQ0 A;  1KUH A;  3VI1 A;  3EDH A;  1JAQ A;  4PKW A;  1BQQ M;  3KEK A;  3EWJ A;  1XUC A;  4G0D A;  4J4M A;  4ZR5 A;  2E2D A;  3TS4 A;  3B92 A;  4HMA A;  2MZH A;  3G5C A;  2HU6 A;  3LEA A;  3WV3 A;  1HOV A;  1OM8 A;  5I2Z A;  2WO9 A;  1JIZ A;  3DTK A;  2OW2 A;  1SRP A;  1Y0V A;  3AYK A;  1ZS0 A;  2W14 A;  2MLR A;  1EAK A;  2SRT A;  4GWM A;  2DW2 A;  3N2U A;  4FXQ A;  2XS3 A;  1O0Q A;  1PWQ A;  3HY7 A;  3MA2 A;  2RJQ A;  1QIB A;  3TSK A;  1SU3 A;  4A7B A;  1R1I A;  1G4K A;  1CIZ A;  1KAP P;  2DDF A;  3LJG A;  1I76 A;  2D1O A;  2JNP A;  3V96 B;  4H76 A;  5BOT A;  2FV5 A;  4DD8 A;  3LIR A;  3HBU P;  1BUV M;  4EFS A;  4H1Q A;  2O3E A;  1IAD A;  1MMP A;  3KEJ A;  4XM8 A;  1KBC A;  3DSL A;  2USN A;  3WV2 A;  1ZTQ A;  4GF1 A;  1AYK A;  1HV5 A;  3AIG A;  2OXU A;  5LAB A;  2OW9 A;  5D2B A;  5D3C A;  3AYU A;  3K7L A;  3L0T A;  3KEC A;  4PKT A;  1BSW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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