2Y6CA

The discovery of mmp7 inhibitors exploiting a novel selectivity trigger
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
165
structure length
161
Chain Sequence
GYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYPQNFKLSQDDIKGIQKLY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords MATRILYSIN
total genus 48
structure length 161
sequence length 165
ec nomenclature ec 3.4.24.23: Matrilysin.
pdb deposition date 2011-01-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2y6cA00
2O3EA 3LJZA 1D5JA 3RTTA 2XS4A 1C7KA 2OVZA 4L63A 2CLTA 3P24A 1ZS0A 3E8RA 1R55A 2K9CA 3NX7A 3LIKA 3B8ZA 3HBVP 3AIGA 1HTDA 4GWNA 1SLNA 1I76A 1EAKA 1J7NA 4AXQA 1BIWA 1JANA 4G9LA 3DSLA 1QJIA 1FM1A 4H3XA 1BQOA 3TSKA 1BM6A 2K2GA 1HV5A 2DW2A 3F17A 2EROA 3Q2GA 3ZVSA 3LILA 3O2XA 4GR0A 5CXAA 3EDIA 1K7GA 1K7IA 1YP1A 4DF9A 1R1HA 2CKIA 2HU6A 2ERPA 5B5OA 1BKCE 1GKDA 2N8RA 4PKQA 1JK3A 2AIGP 3SHIA 2JNPA 2RJPA 1G12A 1PWQA 4J4MA 5D1UA 5B5PA 5D3CA 1Y0VA 3V96B 3LJGA 4IJOA 1L6JA 1OMJA 2TCLA 2OXWA 2Z2DA 1H71P 1AF0A 2OXUA 3N2VA 1O0QA 4WKEA 4R3VA 4I35A 4H76A 1BUVM 966CA 4FXYP 4AUOA 1OM6A 3L0TA 1XUCA 2L0RA 2Y6DA 1PWUA 1Y8JA 4A3WA 1CK7A 1ZVXA 1MMBA 1QIBA 2AYKA 2PJTA 3KEJA 4FU4A 4ILWD 3USNA 5CZMA 2DDYA 4JPAA 3KEKA 4ZR5A 1GE6A 1Z3JA 1KAPP 3HDBA 1XFWA 2MZHA 4XCTA 4WZVA 5I3MA 2DW0A 3B92A 1YCMA 1CGFA 1ZXVA 3K7NA 3DPFA 1ZTQA 3L0VA 1BSWA 4H2EA 4PKVA 5LABA 2OW1A 1JAOA 3F15A 4QKZA 1BKCA 1UTTA 3WV2A 1O0TA 4PKWA 2E2DA 4DD8A 830CA 1D7XA 1BUDA 3TVCA 1G05A 5BOTA 3I7IA 2XS3A 4XM8A 2OW9A 1MMPA 1DTHA 2POJA 1KUIA 5I12A 4ON1A 1CIZA 1KUGA 5D2BA 3LUNA 4H30A 5H8XA 4XM7A 1XFVA 2WOAA 1JKYA 1CQRA 1QUAA 2W15A 4DPEA 1ASTA 1OM8A 1R1JA 1ROSA 1HFCA 3ELMA 3EWJA 4XM6A 3F16A 1IAGA 1GXDA 3OHOA 3LE9A 3Q2HA 5L79A 3KMCA 4L19A 1USNA 3HY7A 2E3XA 3AYKA 3DWBA 4IN9A 2X3CA 3KMEA 3LJTA 1OO9A 3LEAA 1A85A 4PKTA 1B8YA 4EFSA 4PKRA 3LUMA 4GWMA 3RTSA 1JIWP 1IABA 3EHXA 1QJJA 3GBOA 1SMPA 2JIHA 1I1IP 2OY2A 1C3IA 1PWPA 1G9KA 1YQYA 2D1NA 4GF1A 2JSDA 1IAAA 1IADA 5L7FA 4GUYA 2FV9A 4PKUA 4WK7A 2WO8A 2W13A 1XUDA 3UVCA 4WKIA 2OI0A 3F1AA 456CA 1SATA 2SRTA 2X7MA 1HFSA 3TT4A 3VTGA 4HX3A 5CUHA 5BPAA 3U1RA 4DV8A 3LKAA 3LQBA 3EDHA 4JP4A 2W0DA 1SRPA 2FV5A 1OM7A 2YB9A 1A86A 2JT6A 1XFXA 2ERQA 1GE5A 5JMYA 3DL1A 1R54A 4G0DA 3HDAP 1CGLA 3B2ZA 1JJ9A 3KECA 4I03A 3N2UA 3I7GA 3KWVC 3LGPA 5BOYA 2MZEA 4Q1LA 1R1IA 5I43A 1OS2A 2OXZA 4GR3A 1CGEA 3LIRA 3EDGA 3G5CA 3LK8A 4H82A 2DDFA 2QPJA 1CAQA 2D1OA 1IACA 2W12A 2Y6CA 2MZIA 1JIZA 1UTZA 4H49A 2O36A 1FLSA 1YOUA 1CXVA 3O64A 1KBCA 1GKCA 2A8HA 1JH1A 5I4OA 1C8TA 5D1SA 1Q3AA 4L6TA 2J83A 1K7QA 1EB6A 1MNCA 2MLSA 3CKIA 3G42A 3HY9A 3DPEA 1HY7A 1PWVA 1D8MA 1ZXCA 3MA2A 2DW1A 2KRJA 1UEAA 1GO8P 1Y93A 1UMTA 2RJQA 3WV1A 1QIAA 1MMRA 3KRYA 1UMSA 1QICA 3OHLA 4JQGA 5I0LA 1XFUA 1BZSA 5I2ZA 1G4KA 2X3BA 3KHIA 1HOVA 2WO9A 1AYKA 3HYGA 3WV3A 2OW2A 4AYKA 1AKLA 1ATLA 4AIGA 4GR8A 4XBHA 1SU3A 1XURA 1GO7P 3VI1A 4CTHA 1S4BP 1G49A 1SLMA 4JIJA 2W14A 1KUKA 1MMQA 4FXQA 4HMAA 4WF6A 2MLRA 1JAQA 3P1VA 4H84A 2OW0A 5D1TA 1IAEA 1RM8A 1D8FA 1ND1A 1I73A 3DNGA 3HB2P 4GQLA 3HBUP 4FVLA 5D7WA 1BKCI 1GE7A 2X3AA 1JAPA 1FBLA 2V4BA 3AYUA 2OVXA 1XFZA 4A7BA 2JT5A 1PWWA 1BQQM 1WNIA 3LMCA 3ZUKA 3TS4A 3EHYA 2J0TA 3F18A 2YIGA 3F19A 1B3DA 2USNA 2OZRA 4IUWA 4JA1A 1KUHA 4PKSA 3ZXHA 2I47A 1EUBA 1KUFA 3K7LA 1RMZA 1OS9A 1DMTA 3BA0A 4H1QA 1ZP5A 3LQ0A 2OY4A 3EDZA 1XFYA
chains in the Genus database with same CATH superfamily
2O3EA 3LJZA 1D5JA 3RTTA 2XS4A 1C7KA 2OVZA 4L63A 2CLTA 3P24A 1ZS0A 3E8RA 1R55A 2K9CA 3NX7A 3LIKA 3B8ZA 3HBVP 3AIGA 1HTDA 4GWNA 1SLNA 1I76A 1EAKA 1J7NA 4AXQA 1BIWA 1JANA 4G9LA 3DSLA 1QJIA 1FM1A 4H3XA 1BQOA 3TSKA 1BM6A 2K2GA 1HV5A 2DW2A 3F17A 2EROA 3Q2GA 3ZVSA 3LILA 3O2XA 4GR0A 5CXAA 3EDIA 1K7GA 1K7IA 1YP1A 4DF9A 1R1HA 2CKIA 2HU6A 2ERPA 5B5OA 1BKCE 1GKDA 2N8RA 4PKQA 1JK3A 2AIGP 3SHIA 2JNPA 2RJPA 1G12A 1PWQA 4J4MA 5D1UA 5B5PA 5D3CA 1Y0VA 3V96B 3LJGA 4IJOA 1L6JA 1OMJA 2TCLA 2OXWA 1XM5A 2Z2DA 1H71P 1AF0A 2OXUA 3N2VA 1O0QA 4WKEA 4R3VA 4I35A 4H76A 1BUVM 966CA 4FXYP 4AUOA 1OM6A 3L0TA 1XUCA 2L0RA 2Y6DA 1PWUA 1Y8JA 4A3WA 1CK7A 1ZVXA 1MMBA 1QIBA 2AYKA 2PJTA 3KEJA 4FU4A 4ILWD 3USNA 5CZMA 2DDYA 4JPAA 3KEKA 4ZR5A 1GE6A 1Z3JA 1KAPP 3HDBA 1XFWA 2MZHA 4XCTA 4WZVA 5I3MA 2DW0A 3B92A 1YCMA 1CGFA 1ZXVA 3K7NA 3DPFA 1ZTQA 3L0VA 1BSWA 4H2EA 4PKVA 5LABA 2OW1A 1JAOA 3F15A 4QKZA 1BKCA 1UTTA 3WV2A 1O0TA 4PKWA 2E2DA 4DD8A 830CA 1D7XA 1BUDA 3TVCA 1G05A 5BOTA 3I7IA 2XS3A 4XM8A 2OW9A 1MMPA 1DTHA 2POJA 1KUIA 5I12A 4ON1A 1CIZA 1KUGA 5D2BA 3LUNA 4H30A 5H8XA 4XM7A 1XFVA 2WOAA 1JKYA 1CQRA 1QUAA 2W15A 4DPEA 1ASTA 1OM8A 1R1JA 1ROSA 1HFCA 3ELMA 3EWJA 4XM6A 3F16A 1IAGA 1GXDA 3DTIA 3OHOA 3LE9A 3Q2HA 5L79A 3KMCA 4L19A 1USNA 3HY7A 2E3XA 3AYKA 3DWBA 4IN9A 2X3CA 3KMEA 3LJTA 1OO9A 3LEAA 1A85A 1TVIA 4PKTA 1B8YA 4EFSA 4PKRA 3LUMA 4GWMA 3RTSA 1JIWP 1IABA 3EHXA 1QJJA 3GBOA 1SMPA 2JIHA 1I1IP 2OY2A 1C3IA 1PWPA 1G9KA 1YQYA 2D1NA 4GF1A 2JSDA 1IAAA 1IADA 5L7FA 4GUYA 2FV9A 4PKUA 4WK7A 2WO8A 2W13A 1XUDA 2YUFA 3UVCA 4WKIA 2OI0A 3F1AA 456CA 1SATA 2SRTA 2X7MA 1HFSA 3TT4A 3VTGA 4HX3A 5CUHA 5BPAA 3U1RA 4DV8A 3LKAA 3LQBA 3EDHA 4JP4A 2W0DA 1SRPA 2FV5A 1OM7A 2YB9A 1A86A 2JT6A 1XFXA 2ERQA 1GE5A 5JMYA 3DL1A 1R54A 4G0DA 3HDAP 1CGLA 3B2ZA 1JJ9A 3KECA 4I03A 3N2UA 3I7GA 3KWVC 3LGPA 5BOYA 2MZEA 4Q1LA 1R1IA 5I43A 1OS2A 2OXZA 4GR3A 1CGEA 3LIRA 3EDGA 3G5CA 3LK8A 4H82A 3DTKA 2DDFA 2QPJA 1CAQA 2D1OA 1IACA 2W12A 2Y6CA 2MZIA 1JIZA 1UTZA 4H49A 2O36A 1FLSA 1YOUA 1CXVA 3O64A 1KBCA 1GKCA 2A8HA 1JH1A 5I4OA 1C8TA 5D1SA 1Q3AA 4L6TA 2J83A 1K7QA 1EB6A 1MNCA 2MLSA 3CKIA 3G42A 3HY9A 3DPEA 1HY7A 1PWVA 1D8MA 1ZXCA 3MA2A 2DW1A 2KRJA 1UEAA 1GO8P 1Y93A 1UMTA 2RJQA 3WV1A 1QIAA 1MMRA 3KRYA 1UMSA 1QICA 3OHLA 4JQGA 5I0LA 1XFUA 1BZSA 5I2ZA 1G4KA 2X3BA 3KHIA 1HOVA 2WO9A 1AYKA 3HYGA 3WV3A 2OW2A 4AYKA 1AKLA 1ATLA 4AIGA 4GR8A 4XBHA 1SU3A 1XURA 1GO7P 3VI1A 4CTHA 1S4BP 1G49A 1SLMA 4JIJA 2W14A 1KUKA 1MMQA 4FXQA 4HMAA 4WF6A 2MLRA 1JAQA 3P1VA 4H84A 2OW0A 5D1TA 1IAEA 1RM8A 1D8FA 1ND1A 1I73A 3DNGA 3HB2P 4L7AA 4GQLA 3HBUP 4FVLA 5D7WA 1BKCI 1GE7A 2X3AA 1JAPA 1FBLA 2V4BA 3AYUA 2OVXA 1XFZA 4A7BA 2JT5A 1PWWA 1BQQM 1WNIA 3LMCA 3ZUKA 3TS4A 3EHYA 2J0TA 3F18A 2YIGA 3F19A 3DTEA 1B3DA 2USNA 2OZRA 4IUWA 4JA1A 1KUHA 4PKSA 3ZXHA 2I47A 1EUBA 1XAXA 1KUFA 3K7LA 1RMZA 1OS9A 1DMTA 3BA0A 4H1QA 1ZP5A 3LQ0A 2OY4A 1OZ9A 3EDZA 1XFYA
chains in the Genus database with same CATH topology
2O3EA 3LJZA 1D5JA 3RTTA 2XS4A 1C7KA 2OVZA 4L63A 2CLTA 3P24A 1ZS0A 3E8RA 1R55A 2K9CA 3NX7A 3LIKA 3B8ZA 3HBVP 3AIGA 1HTDA 4GWNA 1SLNA 1I76A 1EAKA 1J7NA 4AXQA 1BIWA 1JANA 4G9LA 3DSLA 1QJIA 1FM1A 4H3XA 1BQOA 3TSKA 1BM6A 2K2GA 1HV5A 2DW2A 3F17A 2EROA 3Q2GA 3ZVSA 3LILA 3O2XA 4GR0A 5CXAA 3EDIA 1K7GA 1K7IA 1YP1A 4DF9A 1R1HA 2CKIA 2HU6A 2ERPA 5B5OA 1BKCE 1GKDA 2N8RA 4PKQA 1JK3A 2AIGP 3SHIA 2JNPA 2RJPA 1G12A 1PWQA 4J4MA 5D1UA 5B5PA 5D3CA 1Y0VA 3V96B 3LJGA 4IJOA 1L6JA 1OMJA 2TCLA 2OXWA 2Z2DA 1H71P 1AF0A 2OXUA 3N2VA 1O0QA 4WKEA 4R3VA 4I35A 4H76A 1BUVM 966CA 4FXYP 4AUOA 1OM6A 3L0TA 1XUCA 2L0RA 2Y6DA 1PWUA 1Y8JA 4A3WA 1CK7A 1ZVXA 1MMBA 1QIBA 2AYKA 2PJTA 3KEJA 4FU4A 4ILWD 3USNA 5CZMA 2DDYA 4JPAA 3KEKA 4ZR5A 1GE6A 1Z3JA 1KAPP 3HDBA 1XFWA 2MZHA 4XCTA 4WZVA 5I3MA 2DW0A 3B92A 1YCMA 1CGFA 1ZXVA 3K7NA 3DPFA 1ZTQA 3L0VA 1BSWA 4H2EA 4PKVA 5LABA 2OW1A 1JAOA 3F15A 4QKZA 1BKCA 1UTTA 3WV2A 1O0TA 4PKWA 2E2DA 4DD8A 830CA 1D7XA 1BUDA 3TVCA 1G05A 5BOTA 3I7IA 2XS3A 4XM8A 2OW9A 1MMPA 1DTHA 2POJA 1KUIA 5I12A 4ON1A 1CIZA 1KUGA 5D2BA 3LUNA 4H30A 5H8XA 4XM7A 1XFVA 2WOAA 1JKYA 1CQRA 1QUAA 2W15A 4DPEA 1ASTA 1OM8A 1R1JA 1ROSA 1HFCA 3ELMA 3EWJA 4XM6A 3F16A 1IAGA 1GXDA 3DTIA 3OHOA 3LE9A 3Q2HA 5L79A 3KMCA 4L19A 1USNA 3HY7A 2E3XA 3AYKA 3DWBA 4IN9A 2X3CA 3KMEA 3LJTA 1OO9A 3LEAA 1A85A 4PKTA 1B8YA 4EFSA 4PKRA 3LUMA 4GWMA 3RTSA 1JIWP 1IABA 3EHXA 1QJJA 3GBOA 1SMPA 2JIHA 1I1IP 2OY2A 1C3IA 1PWPA 1G9KA 1YQYA 2D1NA 4GF1A 2JSDA 1IAAA 1IADA 5L7FA 4GUYA 2FV9A 4PKUA 4WK7A 2WO8A 2W13A 1XUDA 2YUFA 3UVCA 4WKIA 2OI0A 3F1AA 456CA 1SATA 2SRTA 2X7MA 1HFSA 3TT4A 3VTGA 4HX3A 5CUHA 5BPAA 3U1RA 4DV8A 3LKAA 3LQBA 3EDHA 4JP4A 2W0DA 1SRPA 2FV5A 1OM7A 2YB9A 1A86A 2JT6A 1XFXA 2ERQA 1GE5A 5JMYA 3DL1A 1R54A 4G0DA 3HDAP 1CGLA 3B2ZA 1JJ9A 3KECA 4I03A 3N2UA 3I7GA 3KWVC 3LGPA 5BOYA 2MZEA 4Q1LA 1R1IA 5I43A 1OS2A 2OXZA 4GR3A 1CGEA 3LIRA 3EDGA 3G5CA 3LK8A 4H82A 3DTKA 2DDFA 2QPJA 1CAQA 2D1OA 1IACA 2W12A 2Y6CA 2MZIA 1JIZA 1UTZA 4H49A 2O36A 1FLSA 1YOUA 1CXVA 3O64A 1KBCA 1GKCA 2A8HA 1JH1A 5I4OA 1C8TA 5D1SA 1Q3AA 4L6TA 2J83A 1K7QA 1EB6A 1MNCA 2MLSA 3CKIA 3G42A 3HY9A 3DPEA 1HY7A 1PWVA 1D8MA 1ZXCA 3MA2A 2DW1A 2KRJA 1UEAA 1GO8P 1Y93A 1UMTA 2RJQA 3WV1A 1QIAA 1MMRA 3KRYA 1UMSA 1QICA 3OHLA 4JQGA 5I0LA 1XFUA 1BZSA 5I2ZA 1G4KA 2X3BA 3KHIA 1HOVA 2WO9A 1AYKA 3HYGA 3WV3A 2OW2A 4AYKA 1AKLA 1ATLA 4AIGA 4GR8A 4XBHA 1SU3A 1XURA 1GO7P 3VI1A 4CTHA 1S4BP 1G49A 1SLMA 4JIJA 2W14A 1KUKA 1MMQA 4FXQA 4HMAA 4WF6A 2MLRA 1JAQA 3P1VA 4H84A 2OW0A 5D1TA 1IAEA 1RM8A 1D8FA 1ND1A 1I73A 3DNGA 3HB2P 4L7AA 4GQLA 3HBUP 4FVLA 5D7WA 1BKCI 1GE7A 2X3AA 1JAPA 1FBLA 2V4BA 3AYUA 2OVXA 1XFZA 4A7BA 2JT5A 1PWWA 1BQQM 1WNIA 3LMCA 3ZUKA 3TS4A 3EHYA 2J0TA 3F18A 2YIGA 3F19A 3DTEA 1B3DA 2USNA 2OZRA 4IUWA 4JA1A 1KUHA 4PKSA 3ZXHA 2I47A 1EUBA 1KUFA 3K7LA 1RMZA 1OS9A 1DMTA 3BA0A 4H1QA 1ZP5A 3LQ0A 2OY4A 3EDZA 1XFYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O3E A;  3LJZ A;  1D5J A;  3RTT A;  2XS4 A;  1C7K A;  2OVZ A;  4L63 A;  2CLT A;  3P24 A;  1ZS0 A;  3E8R A;  1R55 A;  2K9C A;  3NX7 A;  3LIK A;  3B8Z A;  3HBV P;  3AIG A;  1HTD A;  4GWN A;  1SLN A;  1I76 A;  1EAK A;  1J7N A;  4AXQ A;  1BIW A;  1JAN A;  4G9L A;  3DSL A;  1QJI A;  1FM1 A;  4H3X A;  1BQO A;  3TSK A;  1BM6 A;  2K2G A;  1HV5 A;  2DW2 A;  3F17 A;  2ERO A;  3Q2G A;  3ZVS A;  3LIL A;  3O2X A;  4GR0 A;  5CXA A;  3EDI A;  1K7G A;  1K7I A;  1YP1 A;  4DF9 A;  1R1H A;  2CKI A;  2HU6 A;  2ERP A;  5B5O A;  1BKC E;  1GKD A;  2N8R A;  4PKQ A;  1JK3 A;  2AIG P;  3SHI A;  2JNP A;  2RJP A;  1G12 A;  1PWQ A;  4J4M A;  5D1U A;  5B5P A;  5D3C A;  1Y0V A;  3V96 B;  3LJG A;  4IJO A;  1L6J A;  1OMJ A;  2TCL A;  2OXW A;  2Z2D A;  1H71 P;  1AF0 A;  2OXU A;  3N2V A;  1O0Q A;  4WKE A;  4R3V A;  4I35 A;  4H76 A;  1BUV M;  966C A;  4FXY P;  4AUO A;  1OM6 A;  3L0T A;  1XUC A;  2L0R A;  2Y6D A;  1PWU A;  1Y8J A;  4A3W A;  1CK7 A;  1ZVX A;  1MMB A;  1QIB A;  2AYK A;  2PJT A;  3KEJ A;  4FU4 A;  4ILW D;  3USN A;  5CZM A;  2DDY A;  4JPA A;  3KEK A;  4ZR5 A;  1GE6 A;  1Z3J A;  1KAP P;  3HDB A;  1XFW A;  2MZH A;  4XCT A;  4WZV A;  5I3M A;  2DW0 A;  3B92 A;  1YCM A;  1CGF A;  1ZXV A;  3K7N A;  3DPF A;  1ZTQ A;  3L0V A;  1BSW A;  4H2E A;  4PKV A;  5LAB A;  2OW1 A;  1JAO A;  3F15 A;  4QKZ A;  1BKC A;  1UTT A;  3WV2 A;  1O0T A;  4PKW A;  2E2D A;  4DD8 A;  830C A;  1D7X A;  1BUD A;  3TVC A;  1G05 A;  5BOT A;  3I7I A;  2XS3 A;  4XM8 A;  2OW9 A;  1MMP A;  1DTH A;  2POJ A;  1KUI A;  5I12 A;  4ON1 A;  1CIZ A;  1KUG A;  5D2B A;  3LUN A;  4H30 A;  5H8X A;  4XM7 A;  1XFV A;  2WOA A;  1JKY A;  1CQR A;  1QUA A;  2W15 A;  4DPE A;  1AST A;  1OM8 A;  1R1J A;  1ROS A;  1HFC A;  3ELM A;  3EWJ A;  4XM6 A;  3F16 A;  1IAG A;  1GXD A;  3OHO A;  3LE9 A;  3Q2H A;  5L79 A;  3KMC A;  4L19 A;  1USN A;  3HY7 A;  2E3X A;  3AYK A;  3DWB A;  4IN9 A;  2X3C A;  3KME A;  3LJT A;  1OO9 A;  3LEA A;  1A85 A;  4PKT A;  1B8Y A;  4EFS A;  4PKR A;  3LUM A;  4GWM A;  3RTS A;  1JIW P;  1IAB A;  3EHX A;  1QJJ A;  3GBO A;  1SMP A;  2JIH A;  1I1I P;  2OY2 A;  1C3I A;  1PWP A;  1G9K A;  1YQY A;  2D1N A;  4GF1 A;  2JSD A;  1IAA A;  1IAD A;  5L7F A;  4GUY A;  2FV9 A;  4PKU A;  4WK7 A;  2WO8 A;  2W13 A;  1XUD A;  3UVC A;  4WKI A;  2OI0 A;  3F1A A;  456C A;  1SAT A;  2SRT A;  2X7M A;  1HFS A;  3TT4 A;  3VTG A;  4HX3 A;  5CUH A;  5BPA A;  3U1R A;  4DV8 A;  3LKA A;  3LQB A;  3EDH A;  4JP4 A;  2W0D A;  1SRP A;  2FV5 A;  1OM7 A;  2YB9 A;  1A86 A;  2JT6 A;  1XFX A;  2ERQ A;  1GE5 A;  5JMY A;  3DL1 A;  1R54 A;  4G0D A;  3HDA P;  1CGL A;  3B2Z A;  1JJ9 A;  3KEC A;  4I03 A;  3N2U A;  3I7G A;  3KWV C;  3LGP A;  5BOY A;  2MZE A;  4Q1L A;  1R1I A;  5I43 A;  1OS2 A;  2OXZ A;  4GR3 A;  1CGE A;  3LIR A;  3EDG A;  3G5C A;  3LK8 A;  4H82 A;  2DDF A;  2QPJ A;  1CAQ A;  2D1O A;  1IAC A;  2W12 A;  2Y6C A;  2MZI A;  1JIZ A;  1UTZ A;  4H49 A;  2O36 A;  1FLS A;  1YOU A;  1CXV A;  3O64 A;  1KBC A;  1GKC A;  2A8H A;  1JH1 A;  5I4O A;  1C8T A;  5D1S A;  1Q3A A;  4L6T A;  2J83 A;  1K7Q A;  1EB6 A;  1MNC A;  2MLS A;  3CKI A;  3G42 A;  3HY9 A;  3DPE A;  1HY7 A;  1PWV A;  1D8M A;  1ZXC A;  3MA2 A;  2DW1 A;  2KRJ A;  1UEA A;  1GO8 P;  1Y93 A;  1UMT A;  2RJQ A;  3WV1 A;  1QIA A;  1MMR A;  3KRY A;  1UMS A;  1QIC A;  3OHL A;  4JQG A;  5I0L A;  1XFU A;  1BZS A;  5I2Z A;  1G4K A;  2X3B A;  3KHI A;  1HOV A;  2WO9 A;  1AYK A;  3HYG A;  3WV3 A;  2OW2 A;  4AYK A;  1AKL A;  1ATL A;  4AIG A;  4GR8 A;  4XBH A;  1SU3 A;  1XUR A;  1GO7 P;  3VI1 A;  4CTH A;  1S4B P;  1G49 A;  1SLM A;  4JIJ A;  2W14 A;  1KUK A;  1MMQ A;  4FXQ A;  4HMA A;  4WF6 A;  2MLR A;  1JAQ A;  3P1V A;  4H84 A;  2OW0 A;  5D1T A;  1IAE A;  1RM8 A;  1D8F A;  1ND1 A;  1I73 A;  3DNG A;  3HB2 P;  4GQL A;  3HBU P;  4FVL A;  5D7W A;  1BKC I;  1GE7 A;  2X3A A;  1JAP A;  1FBL A;  2V4B A;  3AYU A;  2OVX A;  1XFZ A;  4A7B A;  2JT5 A;  1PWW A;  1BQQ M;  1WNI A;  3LMC A;  3ZUK A;  3TS4 A;  3EHY A;  2J0T A;  3F18 A;  2YIG A;  3F19 A;  1B3D A;  2USN A;  2OZR A;  4IUW A;  4JA1 A;  1KUH A;  4PKS A;  3ZXH A;  2I47 A;  1EUB A;  1KUF A;  3K7L A;  1RMZ A;  1OS9 A;  1DMT A;  3BA0 A;  4H1Q A;  1ZP5 A;  3LQ0 A;  2OY4 A;  3EDZ A;  1XFY A; 
#chains in the Genus database with same CATH topology
 2O3E A;  3LJZ A;  1D5J A;  3RTT A;  2XS4 A;  1C7K A;  2OVZ A;  4L63 A;  2CLT A;  3P24 A;  1ZS0 A;  3E8R A;  1R55 A;  2K9C A;  3NX7 A;  3LIK A;  3B8Z A;  3HBV P;  3AIG A;  1HTD A;  4GWN A;  1SLN A;  1I76 A;  1EAK A;  1J7N A;  4AXQ A;  1BIW A;  1JAN A;  4G9L A;  3DSL A;  1QJI A;  1FM1 A;  4H3X A;  1BQO A;  3TSK A;  1BM6 A;  2K2G A;  1HV5 A;  2DW2 A;  3F17 A;  2ERO A;  3Q2G A;  3ZVS A;  3LIL A;  3O2X A;  4GR0 A;  5CXA A;  3EDI A;  1K7G A;  1K7I A;  1YP1 A;  4DF9 A;  1R1H A;  2CKI A;  2HU6 A;  2ERP A;  5B5O A;  1BKC E;  1GKD A;  2N8R A;  4PKQ A;  1JK3 A;  2AIG P;  3SHI A;  2JNP A;  2RJP A;  1G12 A;  1PWQ A;  4J4M A;  5D1U A;  5B5P A;  5D3C A;  1Y0V A;  3V96 B;  3LJG A;  4IJO A;  1L6J A;  1OMJ A;  2TCL A;  2OXW A;  1XM5 A;  2Z2D A;  1H71 P;  1AF0 A;  2OXU A;  3N2V A;  1O0Q A;  4WKE A;  4R3V A;  4I35 A;  4H76 A;  1BUV M;  966C A;  4FXY P;  4AUO A;  1OM6 A;  3L0T A;  1XUC A;  2L0R A;  2Y6D A;  1PWU A;  1Y8J A;  4A3W A;  1CK7 A;  1ZVX A;  1MMB A;  1QIB A;  2AYK A;  2PJT A;  3KEJ A;  4FU4 A;  4ILW D;  3USN A;  5CZM A;  2DDY A;  4JPA A;  3KEK A;  4ZR5 A;  1GE6 A;  1Z3J A;  1KAP P;  3HDB A;  1XFW A;  2MZH A;  4XCT A;  4WZV A;  5I3M A;  2DW0 A;  3B92 A;  1YCM A;  1CGF A;  1ZXV A;  3K7N A;  3DPF A;  1ZTQ A;  3L0V A;  1BSW A;  4H2E A;  4PKV A;  5LAB A;  2OW1 A;  1JAO A;  3F15 A;  4QKZ A;  1BKC A;  1UTT A;  3WV2 A;  1O0T A;  4PKW A;  2E2D A;  4DD8 A;  830C A;  1D7X A;  1BUD A;  3TVC A;  1G05 A;  5BOT A;  3I7I A;  2XS3 A;  4XM8 A;  2OW9 A;  1MMP A;  1DTH A;  2POJ A;  1KUI A;  5I12 A;  4ON1 A;  1CIZ A;  1KUG A;  5D2B A;  3LUN A;  4H30 A;  5H8X A;  4XM7 A;  1XFV A;  2WOA A;  1JKY A;  1CQR A;  1QUA A;  2W15 A;  4DPE A;  1AST A;  1OM8 A;  1R1J A;  1ROS A;  1HFC A;  3ELM A;  3EWJ A;  4XM6 A;  3F16 A;  1IAG A;  1GXD A;  3DTI A;  3OHO A;  3LE9 A;  3Q2H A;  5L79 A;  3KMC A;  4L19 A;  1USN A;  3HY7 A;  2E3X A;  3AYK A;  3DWB A;  4IN9 A;  2X3C A;  3KME A;  3LJT A;  1OO9 A;  3LEA A;  1A85 A;  1TVI A;  4PKT A;  1B8Y A;  4EFS A;  4PKR A;  3LUM A;  4GWM A;  3RTS A;  1JIW P;  1IAB A;  3EHX A;  1QJJ A;  3GBO A;  1SMP A;  2JIH A;  1I1I P;  2OY2 A;  1C3I A;  1PWP A;  1G9K A;  1YQY A;  2D1N A;  4GF1 A;  2JSD A;  1IAA A;  1IAD A;  5L7F A;  4GUY A;  2FV9 A;  4PKU A;  4WK7 A;  2WO8 A;  2W13 A;  1XUD A;  2YUF A;  3UVC A;  4WKI A;  2OI0 A;  3F1A A;  456C A;  1SAT A;  2SRT A;  2X7M A;  1HFS A;  3TT4 A;  3VTG A;  4HX3 A;  5CUH A;  5BPA A;  3U1R A;  4DV8 A;  3LKA A;  3LQB A;  3EDH A;  4JP4 A;  2W0D A;  1SRP A;  2FV5 A;  1OM7 A;  2YB9 A;  1A86 A;  2JT6 A;  1XFX A;  2ERQ A;  1GE5 A;  5JMY A;  3DL1 A;  1R54 A;  4G0D A;  3HDA P;  1CGL A;  3B2Z A;  1JJ9 A;  3KEC A;  4I03 A;  3N2U A;  3I7G A;  3KWV C;  3LGP A;  5BOY A;  2MZE A;  4Q1L A;  1R1I A;  5I43 A;  1OS2 A;  2OXZ A;  4GR3 A;  1CGE A;  3LIR A;  3EDG A;  3G5C A;  3LK8 A;  4H82 A;  3DTK A;  2DDF A;  2QPJ A;  1CAQ A;  2D1O A;  1IAC A;  2W12 A;  2Y6C A;  2MZI A;  1JIZ A;  1UTZ A;  4H49 A;  2O36 A;  1FLS A;  1YOU A;  1CXV A;  3O64 A;  1KBC A;  1GKC A;  2A8H A;  1JH1 A;  5I4O A;  1C8T A;  5D1S A;  1Q3A A;  4L6T A;  2J83 A;  1K7Q A;  1EB6 A;  1MNC A;  2MLS A;  3CKI A;  3G42 A;  3HY9 A;  3DPE A;  1HY7 A;  1PWV A;  1D8M A;  1ZXC A;  3MA2 A;  2DW1 A;  2KRJ A;  1UEA A;  1GO8 P;  1Y93 A;  1UMT A;  2RJQ A;  3WV1 A;  1QIA A;  1MMR A;  3KRY A;  1UMS A;  1QIC A;  3OHL A;  4JQG A;  5I0L A;  1XFU A;  1BZS A;  5I2Z A;  1G4K A;  2X3B A;  3KHI A;  1HOV A;  2WO9 A;  1AYK A;  3HYG A;  3WV3 A;  2OW2 A;  4AYK A;  1AKL A;  1ATL A;  4AIG A;  4GR8 A;  4XBH A;  1SU3 A;  1XUR A;  1GO7 P;  3VI1 A;  4CTH A;  1S4B P;  1G49 A;  1SLM A;  4JIJ A;  2W14 A;  1KUK A;  1MMQ A;  4FXQ A;  4HMA A;  4WF6 A;  2MLR A;  1JAQ A;  3P1V A;  4H84 A;  2OW0 A;  5D1T A;  1IAE A;  1RM8 A;  1D8F A;  1ND1 A;  1I73 A;  3DNG A;  3HB2 P;  4L7A A;  4GQL A;  3HBU P;  4FVL A;  5D7W A;  1BKC I;  1GE7 A;  2X3A A;  1JAP A;  1FBL A;  2V4B A;  3AYU A;  2OVX A;  1XFZ A;  4A7B A;  2JT5 A;  1PWW A;  1BQQ M;  1WNI A;  3LMC A;  3ZUK A;  3TS4 A;  3EHY A;  2J0T A;  3F18 A;  2YIG A;  3F19 A;  3DTE A;  1B3D A;  2USN A;  2OZR A;  4IUW A;  4JA1 A;  1KUH A;  4PKS A;  3ZXH A;  2I47 A;  1EUB A;  1XAX A;  1KUF A;  3K7L A;  1RMZ A;  1OS9 A;  1DMT A;  3BA0 A;  4H1Q A;  1ZP5 A;  3LQ0 A;  2OY4 A;  1OZ9 A;  3EDZ A;  1XFY A; 
#chains in the Genus database with same CATH homology
 2O3E A;  3LJZ A;  1D5J A;  3RTT A;  2XS4 A;  1C7K A;  2OVZ A;  4L63 A;  2CLT A;  3P24 A;  1ZS0 A;  3E8R A;  1R55 A;  2K9C A;  3NX7 A;  3LIK A;  3B8Z A;  3HBV P;  3AIG A;  1HTD A;  4GWN A;  1SLN A;  1I76 A;  1EAK A;  1J7N A;  4AXQ A;  1BIW A;  1JAN A;  4G9L A;  3DSL A;  1QJI A;  1FM1 A;  4H3X A;  1BQO A;  3TSK A;  1BM6 A;  2K2G A;  1HV5 A;  2DW2 A;  3F17 A;  2ERO A;  3Q2G A;  3ZVS A;  3LIL A;  3O2X A;  4GR0 A;  5CXA A;  3EDI A;  1K7G A;  1K7I A;  1YP1 A;  4DF9 A;  1R1H A;  2CKI A;  2HU6 A;  2ERP A;  5B5O A;  1BKC E;  1GKD A;  2N8R A;  4PKQ A;  1JK3 A;  2AIG P;  3SHI A;  2JNP A;  2RJP A;  1G12 A;  1PWQ A;  4J4M A;  5D1U A;  5B5P A;  5D3C A;  1Y0V A;  3V96 B;  3LJG A;  4IJO A;  1L6J A;  1OMJ A;  2TCL A;  2OXW A;  2Z2D A;  1H71 P;  1AF0 A;  2OXU A;  3N2V A;  1O0Q A;  4WKE A;  4R3V A;  4I35 A;  4H76 A;  1BUV M;  966C A;  4FXY P;  4AUO A;  1OM6 A;  3L0T A;  1XUC A;  2L0R A;  2Y6D A;  1PWU A;  1Y8J A;  4A3W A;  1CK7 A;  1ZVX A;  1MMB A;  1QIB A;  2AYK A;  2PJT A;  3KEJ A;  4FU4 A;  4ILW D;  3USN A;  5CZM A;  2DDY A;  4JPA A;  3KEK A;  4ZR5 A;  1GE6 A;  1Z3J A;  1KAP P;  3HDB A;  1XFW A;  2MZH A;  4XCT A;  4WZV A;  5I3M A;  2DW0 A;  3B92 A;  1YCM A;  1CGF A;  1ZXV A;  3K7N A;  3DPF A;  1ZTQ A;  3L0V A;  1BSW A;  4H2E A;  4PKV A;  5LAB A;  2OW1 A;  1JAO A;  3F15 A;  4QKZ A;  1BKC A;  1UTT A;  3WV2 A;  1O0T A;  4PKW A;  2E2D A;  4DD8 A;  830C A;  1D7X A;  1BUD A;  3TVC A;  1G05 A;  5BOT A;  3I7I A;  2XS3 A;  4XM8 A;  2OW9 A;  1MMP A;  1DTH A;  2POJ A;  1KUI A;  5I12 A;  4ON1 A;  1CIZ A;  1KUG A;  5D2B A;  3LUN A;  4H30 A;  5H8X A;  4XM7 A;  1XFV A;  2WOA A;  1JKY A;  1CQR A;  1QUA A;  2W15 A;  4DPE A;  1AST A;  1OM8 A;  1R1J A;  1ROS A;  1HFC A;  3ELM A;  3EWJ A;  4XM6 A;  3F16 A;  1IAG A;  1GXD A;  3DTI A;  3OHO A;  3LE9 A;  3Q2H A;  5L79 A;  3KMC A;  4L19 A;  1USN A;  3HY7 A;  2E3X A;  3AYK A;  3DWB A;  4IN9 A;  2X3C A;  3KME A;  3LJT A;  1OO9 A;  3LEA A;  1A85 A;  4PKT A;  1B8Y A;  4EFS A;  4PKR A;  3LUM A;  4GWM A;  3RTS A;  1JIW P;  1IAB A;  3EHX A;  1QJJ A;  3GBO A;  1SMP A;  2JIH A;  1I1I P;  2OY2 A;  1C3I A;  1PWP A;  1G9K A;  1YQY A;  2D1N A;  4GF1 A;  2JSD A;  1IAA A;  1IAD A;  5L7F A;  4GUY A;  2FV9 A;  4PKU A;  4WK7 A;  2WO8 A;  2W13 A;  1XUD A;  2YUF A;  3UVC A;  4WKI A;  2OI0 A;  3F1A A;  456C A;  1SAT A;  2SRT A;  2X7M A;  1HFS A;  3TT4 A;  3VTG A;  4HX3 A;  5CUH A;  5BPA A;  3U1R A;  4DV8 A;  3LKA A;  3LQB A;  3EDH A;  4JP4 A;  2W0D A;  1SRP A;  2FV5 A;  1OM7 A;  2YB9 A;  1A86 A;  2JT6 A;  1XFX A;  2ERQ A;  1GE5 A;  5JMY A;  3DL1 A;  1R54 A;  4G0D A;  3HDA P;  1CGL A;  3B2Z A;  1JJ9 A;  3KEC A;  4I03 A;  3N2U A;  3I7G A;  3KWV C;  3LGP A;  5BOY A;  2MZE A;  4Q1L A;  1R1I A;  5I43 A;  1OS2 A;  2OXZ A;  4GR3 A;  1CGE A;  3LIR A;  3EDG A;  3G5C A;  3LK8 A;  4H82 A;  3DTK A;  2DDF A;  2QPJ A;  1CAQ A;  2D1O A;  1IAC A;  2W12 A;  2Y6C A;  2MZI A;  1JIZ A;  1UTZ A;  4H49 A;  2O36 A;  1FLS A;  1YOU A;  1CXV A;  3O64 A;  1KBC A;  1GKC A;  2A8H A;  1JH1 A;  5I4O A;  1C8T A;  5D1S A;  1Q3A A;  4L6T A;  2J83 A;  1K7Q A;  1EB6 A;  1MNC A;  2MLS A;  3CKI A;  3G42 A;  3HY9 A;  3DPE A;  1HY7 A;  1PWV A;  1D8M A;  1ZXC A;  3MA2 A;  2DW1 A;  2KRJ A;  1UEA A;  1GO8 P;  1Y93 A;  1UMT A;  2RJQ A;  3WV1 A;  1QIA A;  1MMR A;  3KRY A;  1UMS A;  1QIC A;  3OHL A;  4JQG A;  5I0L A;  1XFU A;  1BZS A;  5I2Z A;  1G4K A;  2X3B A;  3KHI A;  1HOV A;  2WO9 A;  1AYK A;  3HYG A;  3WV3 A;  2OW2 A;  4AYK A;  1AKL A;  1ATL A;  4AIG A;  4GR8 A;  4XBH A;  1SU3 A;  1XUR A;  1GO7 P;  3VI1 A;  4CTH A;  1S4B P;  1G49 A;  1SLM A;  4JIJ A;  2W14 A;  1KUK A;  1MMQ A;  4FXQ A;  4HMA A;  4WF6 A;  2MLR A;  1JAQ A;  3P1V A;  4H84 A;  2OW0 A;  5D1T A;  1IAE A;  1RM8 A;  1D8F A;  1ND1 A;  1I73 A;  3DNG A;  3HB2 P;  4L7A A;  4GQL A;  3HBU P;  4FVL A;  5D7W A;  1BKC I;  1GE7 A;  2X3A A;  1JAP A;  1FBL A;  2V4B A;  3AYU A;  2OVX A;  1XFZ A;  4A7B A;  2JT5 A;  1PWW A;  1BQQ M;  1WNI A;  3LMC A;  3ZUK A;  3TS4 A;  3EHY A;  2J0T A;  3F18 A;  2YIG A;  3F19 A;  3DTE A;  1B3D A;  2USN A;  2OZR A;  4IUW A;  4JA1 A;  1KUH A;  4PKS A;  3ZXH A;  2I47 A;  1EUB A;  1KUF A;  3K7L A;  1RMZ A;  1OS9 A;  1DMT A;  3BA0 A;  4H1Q A;  1ZP5 A;  3LQ0 A;  2OY4 A;  3EDZ A;  1XFY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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