2HU6A

Crystal structure of human mmp-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
158
structure length
158
Chain Sequence
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 42
structure length 158
sequence length 158
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2006-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2hu6A00
1PWQA 1BIWA 3RTTA 1JH1A 2OI0A 2QPJA 1WNIA 3F17A 1SRPA 1IAGA 3ZUKA 4L6TA 4L19A 1B3DA 5BPAA 1G05A 3LIRA 1SLMA 1YP1A 1JK3A 2MZHA 2OXZA 3TS4A 2W0DA 1JAOA 1BQOA 1HOVA 3I7GA 1XFYA 3U1RA 3LMCA 2RJPA 3V96B 3AYKA 3ZVSA 1H71P 2OY4A 1OS2A 1BUVM 2AYKA 1O0QA 4H30A 1Y93A 5D7WA 3WV1A 4FU4A 3F1AA 3DSLA 3LJGA 1BM6A 4JQGA 3P1VA 4WF6A 3KEJA 4G0DA 1IAAA 3RTSA 3G42A 4I03A 1Y0VA 1IACA 1ND1A 5D1UA 4GR0A 1KAPP 1L6JA 5I3MA 1BUDA 1BSWA 1ZVXA 4H84A 1S4BP 3TVCA 4GF1A 1QICA 2DW1A 4Q1LA 3AIGA 5L79A 1CIZA 1HY7A 3KRYA 1ZP5A 1OS9A 5B5OA 1KUHA 2I47A 1UTTA 1AF0A 3LILA 1BKCI 4IJOA 1ZTQA 1OMJA 3HB2P 1BQQM 1GKDA 2ERPA 1K7QA 1FLSA 1I1IP 5I12A 3WV2A 3ELMA 1YOUA 2OW9A 4WKEA 2D1OA 1K7GA 4H49A 5I4OA 2X3AA 3EDHA 2MZEA 5H8XA 1R1IA 4PKRA 2E3XA 1A86A 1XFVA 2FV9A 1JJ9A 3DNGA 3AYUA 4J4MA 2KRJA 3EDGA 4XM7A 3SHIA 1HFCA 4GWMA 1GXDA 1KUGA 5B5PA 3HDBA 1CQRA 2FV5A 2WO9A 1KUKA 4GWNA 4QKZA 1Y8JA 1A85A 2W15A 3KMEA 3GBOA 3MA2A 3O64A 2JNPA 3OHOA 4IUWA 2OW0A 3NX7A 1JIWP 4PKWA 4GQLA 1D8FA 1UTZA 1EAKA 1HTDA 1CAQA 1PWPA 3DPEA 1RMZA 1GE7A 3EDZA 4AUOA 1PWWA 2TCLA 2WOAA 1OM6A 3F19A 3KEKA 1J7NA 2JIHA 1CGFA 3LUNA 3LE9A 5D1TA 3LQ0A 1GO8P 1C8TA 3E8RA 1D5JA 1GKCA 3F15A 4PKSA 3B2ZA 1JAPA 3DPFA 5D3CA 3Q2HA 1DMTA 3LJZA 3LKAA 5CZMA 3P24A 2O3EA 1BKCE 1FM1A 4CTHA 1ASTA 2DW2A 1R1HA 2JT5A 2POJA 2YB9A 4PKQA 5BOTA 5I0LA 2HU6A 1I76A 2X7MA 3LQBA 3B92A 2K2GA 1SMPA 4FVLA 4H3XA 1MMBA 2MLSA 1MMRA 3LIKA 4EFSA 1I73A 1IAEA 1YQYA 2J83A 2O36A 4R3VA 2OXWA 1MNCA 2SRTA 1G9KA 1CK7A 3DWBA 1ZXVA 1JANA 1R1JA 1ZXCA 2AIGP 4H76A 3EHXA 5L7FA 1R55A 4HMAA 4HX3A 2J0TA 1ROSA 2OW1A 4L63A 4AIGA 5BOYA 2OY2A 2W13A 2RJQA 1SLNA 4FXYP 4FXQA 830CA 4GUYA 1USNA 3KHIA 3L0VA 1IADA 1IABA 3K7LA 1YCMA 3Q2GA 3KWVC 2OW2A 1JAQA 3I7IA 1CGEA 2ERQA 1JIZA 1DTHA 1Z3JA 1ATLA 3EHYA 3OHLA 3N2VA 4I35A 1QUAA 2V4BA 4WK7A 4DPEA 4PKVA 1SATA 3G5CA 2OZRA 3L0TA 2WO8A 1EUBA 2XS4A 1C3IA 4GR8A 966CA 2JSDA 3N2UA 2MLRA 1D8MA 4DF9A 3O2XA 5I2ZA 3HDAP 4DD8A 3LGPA 1UMTA 3ZXHA 1AKLA 1OO9A 1XUDA 5LABA 1FBLA 4IN9A 4JA1A 4WKIA 1C7KA 2YIGA 1OM8A 2W12A 2USNA 1EB6A 3F18A 1HV5A 3B8ZA 5CXAA 1BKCA 4WZVA 1QIAA 5CUHA 1XUCA 1GE6A 3KECA 3VI1A 4PKTA 3HYGA 1SU3A 1K7IA 1QIBA 2JT6A 4H2EA 3HY7A 456CA 2N8RA 1OM7A 1D7XA 2D1NA 3TSKA 1XFWA 3LJTA 5D1SA 3UVCA 2Z2DA 4GR3A 1KUIA 3F16A 1G4KA 1PWVA 4XM8A 1QJIA 3LK8A 4ILWD 1XFUA 1Q3AA 2XS3A 1HFSA 3HY9A 3DL1A 4A7BA 1JKYA 4AYKA 1AYKA 3LUMA 2DDYA 4JPAA 1ZS0A 1KBCA 4H82A 2PJTA 2Y6DA 3VTGA 5I43A 1XFXA 1XURA 3HBVP 1GE5A 2OVXA 2CKIA 3LEAA 2EROA 4XM6A 2X3CA 1G49A 4PKUA 3KMCA 1GO7P 1G12A 1MMPA 1PWUA 2OVZA 3K7NA 4JIJA 4AXQA 2L0RA 4XBHA 3BA0A 4H1QA 2A8HA 1BZSA 2OXUA 1B8YA 2DW0A 1UEAA 2X3BA 1R54A 2W14A 1MMQA 4ON1A 3EWJA 1O0TA 5D2BA 2CLTA 3CKIA 1CGLA 1RM8A 2Y6CA 3HBUP 4XCTA 3WV3A 4ZR5A 3EDIA 4A3WA 3USNA 1CXVA 4DV8A 1KUFA 2E2DA 4G9LA 2K9CA 3TT4A 2DDFA 1QJJA 1XFZA 2MZIA 5JMYA 1UMSA 4JP4A
chains in the Genus database with same CATH superfamily
1PWQA 1BIWA 3RTTA 1JH1A 2OI0A 2QPJA 1WNIA 3F17A 1SRPA 1IAGA 3ZUKA 4L6TA 4L19A 1B3DA 5BPAA 1G05A 3LIRA 1SLMA 1YP1A 1JK3A 2MZHA 2OXZA 2YUFA 3TS4A 2W0DA 1JAOA 1BQOA 1HOVA 3I7GA 1XFYA 3U1RA 3LMCA 2RJPA 3V96B 1XAXA 3AYKA 3ZVSA 1H71P 2OY4A 1OS2A 1BUVM 2AYKA 1O0QA 4H30A 1Y93A 5D7WA 3WV1A 4FU4A 3F1AA 3DSLA 3LJGA 1BM6A 4JQGA 3P1VA 4WF6A 3KEJA 4G0DA 1IAAA 3RTSA 3G42A 4I03A 1Y0VA 1IACA 1ND1A 5D1UA 4GR0A 1KAPP 1L6JA 5I3MA 1BUDA 1BSWA 1ZVXA 4H84A 1S4BP 3TVCA 4GF1A 1QICA 2DW1A 4Q1LA 3AIGA 5L79A 1CIZA 1HY7A 3KRYA 1ZP5A 1OS9A 5B5OA 1KUHA 2I47A 1UTTA 1AF0A 3LILA 1BKCI 4IJOA 1ZTQA 1OMJA 3HB2P 1BQQM 1GKDA 2ERPA 1K7QA 1FLSA 1I1IP 5I12A 3WV2A 3ELMA 1YOUA 2OW9A 4WKEA 2D1OA 1K7GA 1XM5A 4H49A 5I4OA 2X3AA 3EDHA 2MZEA 5H8XA 1R1IA 4PKRA 2E3XA 1A86A 1XFVA 2FV9A 1JJ9A 3DNGA 3AYUA 4J4MA 2KRJA 3EDGA 4XM7A 3SHIA 1HFCA 4GWMA 1GXDA 3DTEA 1KUGA 5B5PA 3HDBA 1CQRA 2FV5A 2WO9A 1KUKA 4GWNA 4QKZA 3DTKA 1Y8JA 1A85A 2W15A 3KMEA 3GBOA 3MA2A 3O64A 2JNPA 3OHOA 4IUWA 2OW0A 3NX7A 1JIWP 4PKWA 4GQLA 4L7AA 1D8FA 1UTZA 1EAKA 1HTDA 1CAQA 1PWPA 3DPEA 1RMZA 1GE7A 3EDZA 4AUOA 1PWWA 2TCLA 2WOAA 1OM6A 3F19A 3KEKA 1J7NA 2JIHA 1CGFA 3LUNA 3LE9A 5D1TA 3LQ0A 1GO8P 1C8TA 3E8RA 1D5JA 1GKCA 3F15A 4PKSA 3B2ZA 1JAPA 3DPFA 5D3CA 3Q2HA 1DMTA 3LJZA 3LKAA 5CZMA 3P24A 2O3EA 1BKCE 1FM1A 4CTHA 1ASTA 2DW2A 1R1HA 2JT5A 2POJA 2YB9A 4PKQA 5BOTA 5I0LA 2HU6A 1I76A 2X7MA 1TVIA 3LQBA 3B92A 2K2GA 1SMPA 4FVLA 4H3XA 1MMBA 2MLSA 1MMRA 3LIKA 4EFSA 1I73A 1IAEA 1YQYA 2J83A 2O36A 4R3VA 2OXWA 1MNCA 2SRTA 1G9KA 1CK7A 3DWBA 1ZXVA 1JANA 1R1JA 1ZXCA 2AIGP 4H76A 3EHXA 5L7FA 1R55A 4HMAA 4HX3A 2J0TA 1ROSA 2OW1A 4L63A 4AIGA 5BOYA 2OY2A 2W13A 2RJQA 1SLNA 4FXYP 4FXQA 830CA 4GUYA 1USNA 3KHIA 3L0VA 1IADA 1IABA 3K7LA 1YCMA 3Q2GA 3KWVC 2OW2A 1JAQA 3I7IA 1CGEA 2ERQA 1JIZA 1DTHA 1Z3JA 1ATLA 3EHYA 3OHLA 3N2VA 4I35A 1QUAA 2V4BA 4WK7A 4DPEA 4PKVA 1SATA 3G5CA 2OZRA 3L0TA 2WO8A 1EUBA 2XS4A 1C3IA 4GR8A 966CA 2JSDA 3N2UA 2MLRA 1D8MA 4DF9A 3O2XA 5I2ZA 3HDAP 4DD8A 3LGPA 1UMTA 3ZXHA 1AKLA 1OO9A 1XUDA 5LABA 1FBLA 4IN9A 4JA1A 4WKIA 1C7KA 2YIGA 1OM8A 2W12A 2USNA 1EB6A 3F18A 1HV5A 3B8ZA 5CXAA 1BKCA 4WZVA 1QIAA 5CUHA 1XUCA 1GE6A 3KECA 3VI1A 1OZ9A 3HYGA 1SU3A 4PKTA 1K7IA 1QIBA 2JT6A 4H2EA 3HY7A 456CA 2N8RA 1OM7A 1D7XA 2D1NA 3TSKA 1XFWA 3LJTA 5D1SA 3UVCA 2Z2DA 4GR3A 1KUIA 3F16A 1G4KA 1PWVA 4XM8A 1QJIA 3LK8A 4ILWD 1XFUA 1Q3AA 2XS3A 3DTIA 1HFSA 3HY9A 3DL1A 4A7BA 1JKYA 4AYKA 1AYKA 3LUMA 2DDYA 4JPAA 1ZS0A 1KBCA 4H82A 2PJTA 2Y6DA 3VTGA 5I43A 1XFXA 1XURA 3HBVP 1GE5A 2OVXA 2CKIA 3LEAA 2EROA 4XM6A 2X3CA 1G49A 4PKUA 3KMCA 1GO7P 1G12A 1MMPA 1PWUA 2OVZA 3K7NA 4JIJA 4AXQA 2L0RA 4XBHA 3BA0A 4H1QA 2A8HA 1BZSA 2OXUA 1B8YA 2DW0A 1UEAA 2X3BA 1R54A 2W14A 1MMQA 4ON1A 3EWJA 1O0TA 5D2BA 2CLTA 3CKIA 1CGLA 1RM8A 2Y6CA 3HBUP 4XCTA 3WV3A 4ZR5A 3EDIA 4A3WA 3USNA 1CXVA 4DV8A 1KUFA 2E2DA 4G9LA 2K9CA 3TT4A 2DDFA 1QJJA 1XFZA 2MZIA 5JMYA 1UMSA 4JP4A
chains in the Genus database with same CATH topology
1PWQA 1BIWA 3RTTA 1JH1A 2OI0A 2QPJA 1WNIA 3F17A 1SRPA 1IAGA 3ZUKA 4L6TA 4L19A 1B3DA 5BPAA 1G05A 3LIRA 1SLMA 1YP1A 1JK3A 2MZHA 2OXZA 2YUFA 3TS4A 2W0DA 1JAOA 1BQOA 1HOVA 3I7GA 1XFYA 3U1RA 3LMCA 2RJPA 3V96B 3AYKA 3ZVSA 1H71P 2OY4A 1OS2A 1BUVM 2AYKA 1O0QA 4H30A 1Y93A 5D7WA 3WV1A 4FU4A 3F1AA 3DSLA 3LJGA 1BM6A 4JQGA 3P1VA 4WF6A 3KEJA 4G0DA 1IAAA 3RTSA 3G42A 4I03A 1Y0VA 1IACA 1ND1A 5D1UA 4GR0A 1KAPP 1L6JA 5I3MA 1BUDA 1BSWA 1ZVXA 4H84A 1S4BP 3TVCA 4GF1A 1QICA 2DW1A 4Q1LA 3AIGA 5L79A 1CIZA 1HY7A 3KRYA 1ZP5A 1OS9A 5B5OA 1KUHA 2I47A 1UTTA 1AF0A 3LILA 1BKCI 4IJOA 1ZTQA 1OMJA 3HB2P 1BQQM 1GKDA 2ERPA 1K7QA 1FLSA 1I1IP 5I12A 3WV2A 3ELMA 1YOUA 2OW9A 4WKEA 2D1OA 1K7GA 4H49A 5I4OA 2X3AA 3EDHA 2MZEA 5H8XA 1R1IA 4PKRA 2E3XA 1A86A 1XFVA 2FV9A 1JJ9A 3DNGA 3AYUA 4J4MA 2KRJA 3EDGA 4XM7A 3SHIA 1HFCA 4GWMA 1GXDA 3DTEA 1KUGA 5B5PA 3HDBA 1CQRA 2FV5A 2WO9A 1KUKA 4GWNA 4QKZA 3DTKA 1Y8JA 1A85A 2W15A 3KMEA 3GBOA 3MA2A 3O64A 2JNPA 3OHOA 4IUWA 2OW0A 3NX7A 1JIWP 4PKWA 4GQLA 4L7AA 1D8FA 1UTZA 1EAKA 1HTDA 1CAQA 1PWPA 3DPEA 1RMZA 1GE7A 3EDZA 4AUOA 1PWWA 2TCLA 2WOAA 1OM6A 3F19A 3KEKA 1J7NA 2JIHA 1CGFA 3LUNA 3LE9A 5D1TA 3LQ0A 1GO8P 1C8TA 3E8RA 1D5JA 1GKCA 3F15A 4PKSA 3B2ZA 1JAPA 3DPFA 5D3CA 3Q2HA 1DMTA 3LJZA 3LKAA 5CZMA 3P24A 2O3EA 1BKCE 1FM1A 4CTHA 1ASTA 2DW2A 1R1HA 2JT5A 2POJA 2YB9A 4PKQA 5BOTA 5I0LA 2HU6A 1I76A 2X7MA 3LQBA 3B92A 2K2GA 1SMPA 4FVLA 4H3XA 1MMBA 2MLSA 1MMRA 3LIKA 4EFSA 1I73A 1IAEA 1YQYA 2J83A 2O36A 4R3VA 2OXWA 1MNCA 2SRTA 1G9KA 1CK7A 3DWBA 1ZXVA 1JANA 1R1JA 1ZXCA 2AIGP 4H76A 3EHXA 5L7FA 1R55A 4HMAA 4HX3A 2J0TA 1ROSA 2OW1A 4L63A 4AIGA 5BOYA 2OY2A 2W13A 2RJQA 1SLNA 4FXYP 4FXQA 830CA 4GUYA 1USNA 3KHIA 3L0VA 1IADA 1IABA 3K7LA 1YCMA 3Q2GA 3KWVC 2OW2A 1JAQA 3I7IA 1CGEA 2ERQA 1JIZA 1DTHA 1Z3JA 1ATLA 3EHYA 3OHLA 3N2VA 4I35A 1QUAA 2V4BA 4WK7A 4DPEA 4PKVA 1SATA 3G5CA 2OZRA 3L0TA 2WO8A 1EUBA 2XS4A 1C3IA 4GR8A 966CA 2JSDA 3N2UA 2MLRA 1D8MA 4DF9A 3O2XA 5I2ZA 3HDAP 4DD8A 3LGPA 1UMTA 3ZXHA 1AKLA 1OO9A 1XUDA 5LABA 1FBLA 4IN9A 4JA1A 4WKIA 1C7KA 2YIGA 1OM8A 2W12A 2USNA 1EB6A 3F18A 1HV5A 3B8ZA 5CXAA 1BKCA 4WZVA 1QIAA 5CUHA 1XUCA 1GE6A 3KECA 3VI1A 4PKTA 3HYGA 1SU3A 1K7IA 1QIBA 2JT6A 4H2EA 3HY7A 456CA 2N8RA 1OM7A 1D7XA 2D1NA 3TSKA 1XFWA 3LJTA 5D1SA 3UVCA 2Z2DA 4GR3A 1KUIA 3F16A 1G4KA 1PWVA 4XM8A 1QJIA 3LK8A 4ILWD 1XFUA 1Q3AA 2XS3A 3DTIA 1HFSA 3HY9A 3DL1A 4A7BA 1JKYA 4AYKA 1AYKA 3LUMA 2DDYA 4JPAA 1ZS0A 1KBCA 4H82A 2PJTA 2Y6DA 3VTGA 5I43A 1XFXA 1XURA 3HBVP 1GE5A 2OVXA 2CKIA 3LEAA 2EROA 4XM6A 2X3CA 1G49A 4PKUA 3KMCA 1GO7P 1G12A 1MMPA 1PWUA 2OVZA 3K7NA 4JIJA 4AXQA 2L0RA 4XBHA 3BA0A 4H1QA 2A8HA 1BZSA 2OXUA 1B8YA 2DW0A 1UEAA 2X3BA 1R54A 2W14A 1MMQA 4ON1A 3EWJA 1O0TA 5D2BA 2CLTA 3CKIA 1CGLA 1RM8A 2Y6CA 3HBUP 4XCTA 3WV3A 4ZR5A 3EDIA 4A3WA 3USNA 1CXVA 4DV8A 1KUFA 2E2DA 4G9LA 2K9CA 3TT4A 2DDFA 1QJJA 1XFZA 2MZIA 5JMYA 1UMSA 4JP4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PWQ A;  1BIW A;  3RTT A;  1JH1 A;  2OI0 A;  2QPJ A;  1WNI A;  3F17 A;  1SRP A;  1IAG A;  3ZUK A;  4L6T A;  4L19 A;  1B3D A;  5BPA A;  1G05 A;  3LIR A;  1SLM A;  1YP1 A;  1JK3 A;  2MZH A;  2OXZ A;  3TS4 A;  2W0D A;  1JAO A;  1BQO A;  1HOV A;  3I7G A;  1XFY A;  3U1R A;  3LMC A;  2RJP A;  3V96 B;  3AYK A;  3ZVS A;  1H71 P;  2OY4 A;  1OS2 A;  1BUV M;  2AYK A;  1O0Q A;  4H30 A;  1Y93 A;  5D7W A;  3WV1 A;  4FU4 A;  3F1A A;  3DSL A;  3LJG A;  1BM6 A;  4JQG A;  3P1V A;  4WF6 A;  3KEJ A;  4G0D A;  1IAA A;  3RTS A;  3G42 A;  4I03 A;  1Y0V A;  1IAC A;  1ND1 A;  5D1U A;  4GR0 A;  1KAP P;  1L6J A;  5I3M A;  1BUD A;  1BSW A;  1ZVX A;  4H84 A;  1S4B P;  3TVC A;  4GF1 A;  1QIC A;  2DW1 A;  4Q1L A;  3AIG A;  5L79 A;  1CIZ A;  1HY7 A;  3KRY A;  1ZP5 A;  1OS9 A;  5B5O A;  1KUH A;  2I47 A;  1UTT A;  1AF0 A;  3LIL A;  1BKC I;  4IJO A;  1ZTQ A;  1OMJ A;  3HB2 P;  1BQQ M;  1GKD A;  2ERP A;  1K7Q A;  1FLS A;  1I1I P;  5I12 A;  3WV2 A;  3ELM A;  1YOU A;  2OW9 A;  4WKE A;  2D1O A;  1K7G A;  4H49 A;  5I4O A;  2X3A A;  3EDH A;  2MZE A;  5H8X A;  1R1I A;  4PKR A;  2E3X A;  1A86 A;  1XFV A;  2FV9 A;  1JJ9 A;  3DNG A;  3AYU A;  4J4M A;  2KRJ A;  3EDG A;  4XM7 A;  3SHI A;  1HFC A;  4GWM A;  1GXD A;  1KUG A;  5B5P A;  3HDB A;  1CQR A;  2FV5 A;  2WO9 A;  1KUK A;  4GWN A;  4QKZ A;  1Y8J A;  1A85 A;  2W15 A;  3KME A;  3GBO A;  3MA2 A;  3O64 A;  2JNP A;  3OHO A;  4IUW A;  2OW0 A;  3NX7 A;  1JIW P;  4PKW A;  4GQL A;  1D8F A;  1UTZ A;  1EAK A;  1HTD A;  1CAQ A;  1PWP A;  3DPE A;  1RMZ A;  1GE7 A;  3EDZ A;  4AUO A;  1PWW A;  2TCL A;  2WOA A;  1OM6 A;  3F19 A;  3KEK A;  1J7N A;  2JIH A;  1CGF A;  3LUN A;  3LE9 A;  5D1T A;  3LQ0 A;  1GO8 P;  1C8T A;  3E8R A;  1D5J A;  1GKC A;  3F15 A;  4PKS A;  3B2Z A;  1JAP A;  3DPF A;  5D3C A;  3Q2H A;  1DMT A;  3LJZ A;  3LKA A;  5CZM A;  3P24 A;  2O3E A;  1BKC E;  1FM1 A;  4CTH A;  1AST A;  2DW2 A;  1R1H A;  2JT5 A;  2POJ A;  2YB9 A;  4PKQ A;  5BOT A;  5I0L A;  2HU6 A;  1I76 A;  2X7M A;  3LQB A;  3B92 A;  2K2G A;  1SMP A;  4FVL A;  4H3X A;  1MMB A;  2MLS A;  1MMR A;  3LIK A;  4EFS A;  1I73 A;  1IAE A;  1YQY A;  2J83 A;  2O36 A;  4R3V A;  2OXW A;  1MNC A;  2SRT A;  1G9K A;  1CK7 A;  3DWB A;  1ZXV A;  1JAN A;  1R1J A;  1ZXC A;  2AIG P;  4H76 A;  3EHX A;  5L7F A;  1R55 A;  4HMA A;  4HX3 A;  2J0T A;  1ROS A;  2OW1 A;  4L63 A;  4AIG A;  5BOY A;  2OY2 A;  2W13 A;  2RJQ A;  1SLN A;  4FXY P;  4FXQ A;  830C A;  4GUY A;  1USN A;  3KHI A;  3L0V A;  1IAD A;  1IAB A;  3K7L A;  1YCM A;  3Q2G A;  3KWV C;  2OW2 A;  1JAQ A;  3I7I A;  1CGE A;  2ERQ A;  1JIZ A;  1DTH A;  1Z3J A;  1ATL A;  3EHY A;  3OHL A;  3N2V A;  4I35 A;  1QUA A;  2V4B A;  4WK7 A;  4DPE A;  4PKV A;  1SAT A;  3G5C A;  2OZR A;  3L0T A;  2WO8 A;  1EUB A;  2XS4 A;  1C3I A;  4GR8 A;  966C A;  2JSD A;  3N2U A;  2MLR A;  1D8M A;  4DF9 A;  3O2X A;  5I2Z A;  3HDA P;  4DD8 A;  3LGP A;  1UMT A;  3ZXH A;  1AKL A;  1OO9 A;  1XUD A;  5LAB A;  1FBL A;  4IN9 A;  4JA1 A;  4WKI A;  1C7K A;  2YIG A;  1OM8 A;  2W12 A;  2USN A;  1EB6 A;  3F18 A;  1HV5 A;  3B8Z A;  5CXA A;  1BKC A;  4WZV A;  1QIA A;  5CUH A;  1XUC A;  1GE6 A;  3KEC A;  3VI1 A;  4PKT A;  3HYG A;  1SU3 A;  1K7I A;  1QIB A;  2JT6 A;  4H2E A;  3HY7 A;  456C A;  2N8R A;  1OM7 A;  1D7X A;  2D1N A;  3TSK A;  1XFW A;  3LJT A;  5D1S A;  3UVC A;  2Z2D A;  4GR3 A;  1KUI A;  3F16 A;  1G4K A;  1PWV A;  4XM8 A;  1QJI A;  3LK8 A;  4ILW D;  1XFU A;  1Q3A A;  2XS3 A;  1HFS A;  3HY9 A;  3DL1 A;  4A7B A;  1JKY A;  4AYK A;  1AYK A;  3LUM A;  2DDY A;  4JPA A;  1ZS0 A;  1KBC A;  4H82 A;  2PJT A;  2Y6D A;  3VTG A;  5I43 A;  1XFX A;  1XUR A;  3HBV P;  1GE5 A;  2OVX A;  2CKI A;  3LEA A;  2ERO A;  4XM6 A;  2X3C A;  1G49 A;  4PKU A;  3KMC A;  1GO7 P;  1G12 A;  1MMP A;  1PWU A;  2OVZ A;  3K7N A;  4JIJ A;  4AXQ A;  2L0R A;  4XBH A;  3BA0 A;  4H1Q A;  2A8H A;  1BZS A;  2OXU A;  1B8Y A;  2DW0 A;  1UEA A;  2X3B A;  1R54 A;  2W14 A;  1MMQ A;  4ON1 A;  3EWJ A;  1O0T A;  5D2B A;  2CLT A;  3CKI A;  1CGL A;  1RM8 A;  2Y6C A;  3HBU P;  4XCT A;  3WV3 A;  4ZR5 A;  3EDI A;  4A3W A;  3USN A;  1CXV A;  4DV8 A;  1KUF A;  2E2D A;  4G9L A;  2K9C A;  3TT4 A;  2DDF A;  1QJJ A;  1XFZ A;  2MZI A;  5JMY A;  1UMS A;  4JP4 A; 
#chains in the Genus database with same CATH topology
 1PWQ A;  1BIW A;  3RTT A;  1JH1 A;  2OI0 A;  2QPJ A;  1WNI A;  3F17 A;  1SRP A;  1IAG A;  3ZUK A;  4L6T A;  4L19 A;  1B3D A;  5BPA A;  1G05 A;  3LIR A;  1SLM A;  1YP1 A;  1JK3 A;  2MZH A;  2OXZ A;  2YUF A;  3TS4 A;  2W0D A;  1JAO A;  1BQO A;  1HOV A;  3I7G A;  1XFY A;  3U1R A;  3LMC A;  2RJP A;  3V96 B;  1XAX A;  3AYK A;  3ZVS A;  1H71 P;  2OY4 A;  1OS2 A;  1BUV M;  2AYK A;  1O0Q A;  4H30 A;  1Y93 A;  5D7W A;  3WV1 A;  4FU4 A;  3F1A A;  3DSL A;  3LJG A;  1BM6 A;  4JQG A;  3P1V A;  4WF6 A;  3KEJ A;  4G0D A;  1IAA A;  3RTS A;  3G42 A;  4I03 A;  1Y0V A;  1IAC A;  1ND1 A;  5D1U A;  4GR0 A;  1KAP P;  1L6J A;  5I3M A;  1BUD A;  1BSW A;  1ZVX A;  4H84 A;  1S4B P;  3TVC A;  4GF1 A;  1QIC A;  2DW1 A;  4Q1L A;  3AIG A;  5L79 A;  1CIZ A;  1HY7 A;  3KRY A;  1ZP5 A;  1OS9 A;  5B5O A;  1KUH A;  2I47 A;  1UTT A;  1AF0 A;  3LIL A;  1BKC I;  4IJO A;  1ZTQ A;  1OMJ A;  3HB2 P;  1BQQ M;  1GKD A;  2ERP A;  1K7Q A;  1FLS A;  1I1I P;  5I12 A;  3WV2 A;  3ELM A;  1YOU A;  2OW9 A;  4WKE A;  2D1O A;  1K7G A;  1XM5 A;  4H49 A;  5I4O A;  2X3A A;  3EDH A;  2MZE A;  5H8X A;  1R1I A;  4PKR A;  2E3X A;  1A86 A;  1XFV A;  2FV9 A;  1JJ9 A;  3DNG A;  3AYU A;  4J4M A;  2KRJ A;  3EDG A;  4XM7 A;  3SHI A;  1HFC A;  4GWM A;  1GXD A;  3DTE A;  1KUG A;  5B5P A;  3HDB A;  1CQR A;  2FV5 A;  2WO9 A;  1KUK A;  4GWN A;  4QKZ A;  3DTK A;  1Y8J A;  1A85 A;  2W15 A;  3KME A;  3GBO A;  3MA2 A;  3O64 A;  2JNP A;  3OHO A;  4IUW A;  2OW0 A;  3NX7 A;  1JIW P;  4PKW A;  4GQL A;  4L7A A;  1D8F A;  1UTZ A;  1EAK A;  1HTD A;  1CAQ A;  1PWP A;  3DPE A;  1RMZ A;  1GE7 A;  3EDZ A;  4AUO A;  1PWW A;  2TCL A;  2WOA A;  1OM6 A;  3F19 A;  3KEK A;  1J7N A;  2JIH A;  1CGF A;  3LUN A;  3LE9 A;  5D1T A;  3LQ0 A;  1GO8 P;  1C8T A;  3E8R A;  1D5J A;  1GKC A;  3F15 A;  4PKS A;  3B2Z A;  1JAP A;  3DPF A;  5D3C A;  3Q2H A;  1DMT A;  3LJZ A;  3LKA A;  5CZM A;  3P24 A;  2O3E A;  1BKC E;  1FM1 A;  4CTH A;  1AST A;  2DW2 A;  1R1H A;  2JT5 A;  2POJ A;  2YB9 A;  4PKQ A;  5BOT A;  5I0L A;  2HU6 A;  1I76 A;  2X7M A;  1TVI A;  3LQB A;  3B92 A;  2K2G A;  1SMP A;  4FVL A;  4H3X A;  1MMB A;  2MLS A;  1MMR A;  3LIK A;  4EFS A;  1I73 A;  1IAE A;  1YQY A;  2J83 A;  2O36 A;  4R3V A;  2OXW A;  1MNC A;  2SRT A;  1G9K A;  1CK7 A;  3DWB A;  1ZXV A;  1JAN A;  1R1J A;  1ZXC A;  2AIG P;  4H76 A;  3EHX A;  5L7F A;  1R55 A;  4HMA A;  4HX3 A;  2J0T A;  1ROS A;  2OW1 A;  4L63 A;  4AIG A;  5BOY A;  2OY2 A;  2W13 A;  2RJQ A;  1SLN A;  4FXY P;  4FXQ A;  830C A;  4GUY A;  1USN A;  3KHI A;  3L0V A;  1IAD A;  1IAB A;  3K7L A;  1YCM A;  3Q2G A;  3KWV C;  2OW2 A;  1JAQ A;  3I7I A;  1CGE A;  2ERQ A;  1JIZ A;  1DTH A;  1Z3J A;  1ATL A;  3EHY A;  3OHL A;  3N2V A;  4I35 A;  1QUA A;  2V4B A;  4WK7 A;  4DPE A;  4PKV A;  1SAT A;  3G5C A;  2OZR A;  3L0T A;  2WO8 A;  1EUB A;  2XS4 A;  1C3I A;  4GR8 A;  966C A;  2JSD A;  3N2U A;  2MLR A;  1D8M A;  4DF9 A;  3O2X A;  5I2Z A;  3HDA P;  4DD8 A;  3LGP A;  1UMT A;  3ZXH A;  1AKL A;  1OO9 A;  1XUD A;  5LAB A;  1FBL A;  4IN9 A;  4JA1 A;  4WKI A;  1C7K A;  2YIG A;  1OM8 A;  2W12 A;  2USN A;  1EB6 A;  3F18 A;  1HV5 A;  3B8Z A;  5CXA A;  1BKC A;  4WZV A;  1QIA A;  5CUH A;  1XUC A;  1GE6 A;  3KEC A;  3VI1 A;  1OZ9 A;  3HYG A;  1SU3 A;  4PKT A;  1K7I A;  1QIB A;  2JT6 A;  4H2E A;  3HY7 A;  456C A;  2N8R A;  1OM7 A;  1D7X A;  2D1N A;  3TSK A;  1XFW A;  3LJT A;  5D1S A;  3UVC A;  2Z2D A;  4GR3 A;  1KUI A;  3F16 A;  1G4K A;  1PWV A;  4XM8 A;  1QJI A;  3LK8 A;  4ILW D;  1XFU A;  1Q3A A;  2XS3 A;  3DTI A;  1HFS A;  3HY9 A;  3DL1 A;  4A7B A;  1JKY A;  4AYK A;  1AYK A;  3LUM A;  2DDY A;  4JPA A;  1ZS0 A;  1KBC A;  4H82 A;  2PJT A;  2Y6D A;  3VTG A;  5I43 A;  1XFX A;  1XUR A;  3HBV P;  1GE5 A;  2OVX A;  2CKI A;  3LEA A;  2ERO A;  4XM6 A;  2X3C A;  1G49 A;  4PKU A;  3KMC A;  1GO7 P;  1G12 A;  1MMP A;  1PWU A;  2OVZ A;  3K7N A;  4JIJ A;  4AXQ A;  2L0R A;  4XBH A;  3BA0 A;  4H1Q A;  2A8H A;  1BZS A;  2OXU A;  1B8Y A;  2DW0 A;  1UEA A;  2X3B A;  1R54 A;  2W14 A;  1MMQ A;  4ON1 A;  3EWJ A;  1O0T A;  5D2B A;  2CLT A;  3CKI A;  1CGL A;  1RM8 A;  2Y6C A;  3HBU P;  4XCT A;  3WV3 A;  4ZR5 A;  3EDI A;  4A3W A;  3USN A;  1CXV A;  4DV8 A;  1KUF A;  2E2D A;  4G9L A;  2K9C A;  3TT4 A;  2DDF A;  1QJJ A;  1XFZ A;  2MZI A;  5JMY A;  1UMS A;  4JP4 A; 
#chains in the Genus database with same CATH homology
 1PWQ A;  1BIW A;  3RTT A;  1JH1 A;  2OI0 A;  2QPJ A;  1WNI A;  3F17 A;  1SRP A;  1IAG A;  3ZUK A;  4L6T A;  4L19 A;  1B3D A;  5BPA A;  1G05 A;  3LIR A;  1SLM A;  1YP1 A;  1JK3 A;  2MZH A;  2OXZ A;  2YUF A;  3TS4 A;  2W0D A;  1JAO A;  1BQO A;  1HOV A;  3I7G A;  1XFY A;  3U1R A;  3LMC A;  2RJP A;  3V96 B;  3AYK A;  3ZVS A;  1H71 P;  2OY4 A;  1OS2 A;  1BUV M;  2AYK A;  1O0Q A;  4H30 A;  1Y93 A;  5D7W A;  3WV1 A;  4FU4 A;  3F1A A;  3DSL A;  3LJG A;  1BM6 A;  4JQG A;  3P1V A;  4WF6 A;  3KEJ A;  4G0D A;  1IAA A;  3RTS A;  3G42 A;  4I03 A;  1Y0V A;  1IAC A;  1ND1 A;  5D1U A;  4GR0 A;  1KAP P;  1L6J A;  5I3M A;  1BUD A;  1BSW A;  1ZVX A;  4H84 A;  1S4B P;  3TVC A;  4GF1 A;  1QIC A;  2DW1 A;  4Q1L A;  3AIG A;  5L79 A;  1CIZ A;  1HY7 A;  3KRY A;  1ZP5 A;  1OS9 A;  5B5O A;  1KUH A;  2I47 A;  1UTT A;  1AF0 A;  3LIL A;  1BKC I;  4IJO A;  1ZTQ A;  1OMJ A;  3HB2 P;  1BQQ M;  1GKD A;  2ERP A;  1K7Q A;  1FLS A;  1I1I P;  5I12 A;  3WV2 A;  3ELM A;  1YOU A;  2OW9 A;  4WKE A;  2D1O A;  1K7G A;  4H49 A;  5I4O A;  2X3A A;  3EDH A;  2MZE A;  5H8X A;  1R1I A;  4PKR A;  2E3X A;  1A86 A;  1XFV A;  2FV9 A;  1JJ9 A;  3DNG A;  3AYU A;  4J4M A;  2KRJ A;  3EDG A;  4XM7 A;  3SHI A;  1HFC A;  4GWM A;  1GXD A;  3DTE A;  1KUG A;  5B5P A;  3HDB A;  1CQR A;  2FV5 A;  2WO9 A;  1KUK A;  4GWN A;  4QKZ A;  3DTK A;  1Y8J A;  1A85 A;  2W15 A;  3KME A;  3GBO A;  3MA2 A;  3O64 A;  2JNP A;  3OHO A;  4IUW A;  2OW0 A;  3NX7 A;  1JIW P;  4PKW A;  4GQL A;  4L7A A;  1D8F A;  1UTZ A;  1EAK A;  1HTD A;  1CAQ A;  1PWP A;  3DPE A;  1RMZ A;  1GE7 A;  3EDZ A;  4AUO A;  1PWW A;  2TCL A;  2WOA A;  1OM6 A;  3F19 A;  3KEK A;  1J7N A;  2JIH A;  1CGF A;  3LUN A;  3LE9 A;  5D1T A;  3LQ0 A;  1GO8 P;  1C8T A;  3E8R A;  1D5J A;  1GKC A;  3F15 A;  4PKS A;  3B2Z A;  1JAP A;  3DPF A;  5D3C A;  3Q2H A;  1DMT A;  3LJZ A;  3LKA A;  5CZM A;  3P24 A;  2O3E A;  1BKC E;  1FM1 A;  4CTH A;  1AST A;  2DW2 A;  1R1H A;  2JT5 A;  2POJ A;  2YB9 A;  4PKQ A;  5BOT A;  5I0L A;  2HU6 A;  1I76 A;  2X7M A;  3LQB A;  3B92 A;  2K2G A;  1SMP A;  4FVL A;  4H3X A;  1MMB A;  2MLS A;  1MMR A;  3LIK A;  4EFS A;  1I73 A;  1IAE A;  1YQY A;  2J83 A;  2O36 A;  4R3V A;  2OXW A;  1MNC A;  2SRT A;  1G9K A;  1CK7 A;  3DWB A;  1ZXV A;  1JAN A;  1R1J A;  1ZXC A;  2AIG P;  4H76 A;  3EHX A;  5L7F A;  1R55 A;  4HMA A;  4HX3 A;  2J0T A;  1ROS A;  2OW1 A;  4L63 A;  4AIG A;  5BOY A;  2OY2 A;  2W13 A;  2RJQ A;  1SLN A;  4FXY P;  4FXQ A;  830C A;  4GUY A;  1USN A;  3KHI A;  3L0V A;  1IAD A;  1IAB A;  3K7L A;  1YCM A;  3Q2G A;  3KWV C;  2OW2 A;  1JAQ A;  3I7I A;  1CGE A;  2ERQ A;  1JIZ A;  1DTH A;  1Z3J A;  1ATL A;  3EHY A;  3OHL A;  3N2V A;  4I35 A;  1QUA A;  2V4B A;  4WK7 A;  4DPE A;  4PKV A;  1SAT A;  3G5C A;  2OZR A;  3L0T A;  2WO8 A;  1EUB A;  2XS4 A;  1C3I A;  4GR8 A;  966C A;  2JSD A;  3N2U A;  2MLR A;  1D8M A;  4DF9 A;  3O2X A;  5I2Z A;  3HDA P;  4DD8 A;  3LGP A;  1UMT A;  3ZXH A;  1AKL A;  1OO9 A;  1XUD A;  5LAB A;  1FBL A;  4IN9 A;  4JA1 A;  4WKI A;  1C7K A;  2YIG A;  1OM8 A;  2W12 A;  2USN A;  1EB6 A;  3F18 A;  1HV5 A;  3B8Z A;  5CXA A;  1BKC A;  4WZV A;  1QIA A;  5CUH A;  1XUC A;  1GE6 A;  3KEC A;  3VI1 A;  4PKT A;  3HYG A;  1SU3 A;  1K7I A;  1QIB A;  2JT6 A;  4H2E A;  3HY7 A;  456C A;  2N8R A;  1OM7 A;  1D7X A;  2D1N A;  3TSK A;  1XFW A;  3LJT A;  5D1S A;  3UVC A;  2Z2D A;  4GR3 A;  1KUI A;  3F16 A;  1G4K A;  1PWV A;  4XM8 A;  1QJI A;  3LK8 A;  4ILW D;  1XFU A;  1Q3A A;  2XS3 A;  3DTI A;  1HFS A;  3HY9 A;  3DL1 A;  4A7B A;  1JKY A;  4AYK A;  1AYK A;  3LUM A;  2DDY A;  4JPA A;  1ZS0 A;  1KBC A;  4H82 A;  2PJT A;  2Y6D A;  3VTG A;  5I43 A;  1XFX A;  1XUR A;  3HBV P;  1GE5 A;  2OVX A;  2CKI A;  3LEA A;  2ERO A;  4XM6 A;  2X3C A;  1G49 A;  4PKU A;  3KMC A;  1GO7 P;  1G12 A;  1MMP A;  1PWU A;  2OVZ A;  3K7N A;  4JIJ A;  4AXQ A;  2L0R A;  4XBH A;  3BA0 A;  4H1Q A;  2A8H A;  1BZS A;  2OXU A;  1B8Y A;  2DW0 A;  1UEA A;  2X3B A;  1R54 A;  2W14 A;  1MMQ A;  4ON1 A;  3EWJ A;  1O0T A;  5D2B A;  2CLT A;  3CKI A;  1CGL A;  1RM8 A;  2Y6C A;  3HBU P;  4XCT A;  3WV3 A;  4ZR5 A;  3EDI A;  4A3W A;  3USN A;  1CXV A;  4DV8 A;  1KUF A;  2E2D A;  4G9L A;  2K9C A;  3TT4 A;  2DDF A;  1QJJ A;  1XFZ A;  2MZI A;  5JMY A;  1UMS A;  4JP4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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