2YB9A

Crystal structure of human neutral endopeptidase complexed with a heteroarylalanine diacid.
Total Genus 270
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
270
sequence length
696
structure length
696
Chain Sequence
GICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Synthesis and Evaluation of Heteroarylalanine Diacids as Potent and Selective Neutral Endopeptidase Inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords NEPRILYSIN
total genus 270
structure length 696
sequence length 696
ec nomenclature ec 3.4.24.11: Neprilysin.
pdb deposition date 2011-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01431 Peptidase_M13 Peptidase family M13
A PF05649 Peptidase_M13_N Peptidase family M13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1380.10 Mainly Alpha Orthogonal Bundle Neutral endopeptidase; domain 2 Neutral endopeptidase , domain2 2yb9A02
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 2yb9A01
1BQOA 2W13A 4AXQA 1RM8A 4JIJA 2E2DA 1OMJA 4I03A 1SU3A 2XS4A 3P1VA 1YP1A 2N8RA 1A85A 4CTHA 3KEKA 3F17A 1MMRA 3O64A 3LIKA 1JK3A 2SRTA 1XUCA 3LILA 3LE9A 2EROA 1ROSA 3P24A 1AF0A 3DL1A 3HDBA 4PKUA 4GQLA 4GF1A 1CIZA 2W12A 1OO9A 4IJOA 4WKEA 3L0TA 4GUYA 3G42A 1GE7A 4L6TA 4XCTA 1XFVA 1G4KA 1FBLA 1SATA 2OW0A 3SHIA 1UMTA 3ZUKA 3RTTA 3VTGA 5I4OA 4DF9A 1JIWP 1R1IA 1PWQA 5I2ZA 3Q2GA 2AYKA 2JNPA 4FXYP 3TT4A 456CA 1JAQA 1QJIA 3I7IA 3L0VA 1JIZA 4WK7A 3EDHA 5D1UA 1HY7A 1IAGA 4JPAA 1OM8A 1EUBA 2PJTA 1ATLA 1BSWA 2JT6A 3LIRA 2RJQA 1USNA 1DMTA 4XM7A 1ZP5A 3E8RA 2DDYA 2AIGP 3DNGA 1OM7A 1SLNA 3AYUA 3DWBA 4DV8A 3EWJA 5JMYA 1HV5A 830CA 2X3AA 3LJZA 1PWPA 3HYGA 3F1AA 3KHIA 3G5CA 3LJTA 4FU4A 4H30A 1HFCA 1IACA 5I43A 4FVLA 3ZXHA 3LQBA 3OHLA 1ASTA 3N2UA 2WO8A 1OS2A 1O0TA 2OXUA 2W14A 3EDZA 1JH1A 2FV5A 1MMQA 3F15A 1XURA 2V4BA 1YOUA 3V96B 3KRYA 2JT5A 3NX7A 1CGFA 4ON1A 3B8ZA 5D1SA 4Q1LA 1UTZA 1RMZA 4WKIA 5I12A 3F18A 3ZVSA 5D7WA 1C8TA 5BOYA 1A86A 4AYKA 5BPAA 4FXQA 3KMCA 3KWVC 3K7NA 1IAEA 4L63A 4DD8A 3HY9A 3HBVP 2MZEA 3LMCA 1K7GA 4H2EA 4AUOA 4A3WA 4G0DA 3U1RA 4XM8A 3RTSA 1G12A 2L0RA 2XS3A 2CLTA 1JANA 2TCLA 3EHXA 1R54A 5D1TA 5CUHA 1B3DA 1HTDA 4EFSA 1C7KA 1QICA 2OVXA 1DTHA 3LUMA 4HX3A 1UTTA 4GWNA 4XM6A 2O3EA 2OXWA 1D8FA 3DPFA 1G9KA 3DPEA 2WOAA 1GE5A 1CK7A 3I7GA 1GKCA 2Y6CA 1GKDA 1GXDA 4WF6A 1MMPA 3AYKA 2MLRA 2J0TA 5CXAA 1XFYA 3LEAA 2HU6A 1C3IA 3GBOA 4R3VA 3TSKA 2D1NA 3B2ZA 1QIAA 5L79A 1ZTQA 3HB2P 4DPEA 1YCMA 1G05A 1B8YA 4GWMA 2OY4A 4IN9A 1BZSA 1BKCI 1Y93A 1KUGA 1D8MA 5D3CA 2YIGA 1KUKA 2OVZA 4H76A 4H84A 3LUNA 1ZXCA 4PKSA 3UVCA 3EDIA 1XFUA 2A8HA 2DW1A 3LQ0A 1H71P 2J83A 1QIBA 1I76A 4QKZA 1R1HA 5B5OA 1GO8P 4L19A 1UMSA 1IADA 2DDFA 1JJ9A 2OZRA 2I47A 4GR3A 1MMBA 3BA0A 1HFSA 2ERPA 4PKWA 1BUDA 1SLMA 3CKIA 2X3CA 1PWVA 1ZS0A 5H8XA 2W0DA 1D7XA 3HBUP 1ND1A 2W15A 4JA1A 3TVCA 1AYKA 3F19A 4PKRA 3EHYA 1ZVXA 1EB6A 1G49A 1MNCA 1Q3AA 2Y6DA 3OHOA 2OI0A 4PKQA 3AIGA 4G9LA 4IUWA 3KMEA 5I0LA 2DW0A 2WO9A 1IABA 5L7FA 4HMAA 2POJA 2JIHA 2RJPA 4AIGA 1I73A 966CA 4J4MA 1CAQA 3LGPA 1L6JA 1WNIA 1KAPP 1KUHA 3WV2A 1QUAA 3ELMA 1FLSA 2OW9A 1AKLA 1D5JA 5BOTA 4H1QA 2YB9A 1SMPA 3EDGA 1ZXVA 4ILWD 1BIWA 2OY2A 4PKVA 1BM6A 1JAPA 3MA2A 1PWWA 1JKYA 5I3MA 1YQYA 4H3XA 3HY7A 4H49A 2O36A 3WV1A 4I35A 2ERQA 4GR0A 4JP4A 1UEAA 3LJGA 1CGEA 4ZR5A 3KECA 3LKAA 1XFZA 2JSDA 1Y0VA 3USNA 1QJJA 1OS9A 3KEJA 1HOVA 1S4BP 1CQRA 3O2XA 3DSLA 4H82A 2E3XA 1GE6A 3LK8A 5B5PA 3WV3A 1FM1A 2X3BA 1I1IP 5D2BA 2MZIA 1Y8JA 1BKCE 2QPJA 3VI1A 4JQGA 2OXZA 4GR8A 1R1JA 2D1OA 1JAOA 1CXVA 1Z3JA 4PKTA 1BQQM 1GO7P 2OW2A 2FV9A 2CKIA 1OM6A 1EAKA 3N2VA 3Q2HA 2MLSA 1KUFA 2K9CA 1XFWA 1J7NA 3F16A 2OW1A 1CGLA 1KUIA 1IAAA 2KRJA 4A7BA 5LABA 1KBCA 3K7LA 5CZMA 1SRPA 4XBHA 3TS4A 3B92A 1XFXA 2K2GA 2Z2DA 1BKCA 2X7MA 1K7QA 1PWUA 1O0QA 1K7IA 3HDAP 1BUVM 1XUDA 1R55A 4WZVA 2DW2A 2USNA 2MZHA
chains in the Genus database with same CATH superfamily
1BQOA 2W13A 4AXQA 1RM8A 4JIJA 2E2DA 1OMJA 4I03A 1SU3A 2XS4A 3P1VA 1YP1A 2N8RA 1A85A 4CTHA 3KEKA 3F17A 1MMRA 3O64A 3LIKA 1JK3A 2SRTA 1XUCA 3LILA 3LE9A 2EROA 1ROSA 3P24A 1AF0A 3DL1A 3HDBA 4PKUA 4GQLA 4GF1A 1CIZA 2W12A 1OO9A 4IJOA 4WKEA 3L0TA 4GUYA 3G42A 1GE7A 4L6TA 4XCTA 1XFVA 1G4KA 1FBLA 1SATA 2OW0A 3SHIA 1UMTA 3ZUKA 3RTTA 3VTGA 5I4OA 4DF9A 1JIWP 1R1IA 1PWQA 5I2ZA 3Q2GA 2AYKA 2JNPA 4FXYP 3TT4A 456CA 1JAQA 1QJIA 3I7IA 3L0VA 1JIZA 4WK7A 3EDHA 5D1UA 1HY7A 1IAGA 4JPAA 1OM8A 1EUBA 2PJTA 1ATLA 1BSWA 2JT6A 3LIRA 2RJQA 1USNA 1DMTA 4XM7A 1ZP5A 3E8RA 2DDYA 2AIGP 3DNGA 1XAXA 1OM7A 1SLNA 3AYUA 3DWBA 4DV8A 3EWJA 5JMYA 1HV5A 830CA 1OZ9A 2X3AA 3LJZA 1PWPA 3HYGA 3F1AA 3KHIA 3G5CA 3LJTA 4FU4A 4H30A 1HFCA 1IACA 5I43A 4FVLA 3ZXHA 3LQBA 3OHLA 1ASTA 3N2UA 2WO8A 1OS2A 1O0TA 2OXUA 2W14A 3EDZA 1JH1A 2FV5A 1MMQA 3F15A 1XURA 2V4BA 1YOUA 3V96B 3KRYA 2JT5A 3NX7A 1CGFA 3DTKA 4ON1A 3B8ZA 5D1SA 4Q1LA 1UTZA 1RMZA 4WKIA 5I12A 3F18A 3ZVSA 5D7WA 1C8TA 5BOYA 1A86A 4AYKA 5BPAA 4FXQA 3KMCA 3KWVC 3K7NA 1IAEA 4L63A 4DD8A 3HY9A 3HBVP 2MZEA 3LMCA 1K7GA 4H2EA 4AUOA 4A3WA 4G0DA 3U1RA 4XM8A 3RTSA 1TVIA 1G12A 2L0RA 2XS3A 2CLTA 1JANA 2TCLA 2YUFA 3EHXA 1R54A 5D1TA 5CUHA 1B3DA 1HTDA 4EFSA 1C7KA 1QICA 2OVXA 1DTHA 3LUMA 4HX3A 1UTTA 4GWNA 4XM6A 2O3EA 2OXWA 1D8FA 3DPFA 1G9KA 3DPEA 2WOAA 1GE5A 1CK7A 3I7GA 1GKCA 2Y6CA 1GKDA 1GXDA 4WF6A 1MMPA 3AYKA 2MLRA 2J0TA 5CXAA 1XFYA 3LEAA 2HU6A 1C3IA 3GBOA 4R3VA 3TSKA 2D1NA 3B2ZA 1QIAA 5L79A 1ZTQA 3HB2P 4DPEA 1YCMA 1G05A 1B8YA 4GWMA 2OY4A 4IN9A 1BZSA 1BKCI 1Y93A 1KUGA 1D8MA 5D3CA 2YIGA 1KUKA 2OVZA 4H76A 4H84A 3LUNA 1ZXCA 4PKSA 3UVCA 3EDIA 1XFUA 2A8HA 2DW1A 3LQ0A 1H71P 2J83A 1QIBA 1I76A 4QKZA 1R1HA 5B5OA 1GO8P 4L19A 1UMSA 1IADA 2DDFA 1JJ9A 2OZRA 2I47A 4GR3A 1MMBA 3BA0A 3DTIA 1HFSA 2ERPA 4PKWA 1BUDA 1SLMA 3CKIA 2X3CA 1PWVA 1ZS0A 5H8XA 2W0DA 1D7XA 3HBUP 1ND1A 2W15A 4JA1A 3TVCA 1AYKA 3F19A 4PKRA 3EHYA 1ZVXA 1EB6A 1G49A 1MNCA 1Q3AA 2Y6DA 3OHOA 2OI0A 4PKQA 3AIGA 4G9LA 4IUWA 3KMEA 5I0LA 2DW0A 2WO9A 1IABA 4L7AA 5L7FA 4HMAA 2POJA 2JIHA 2RJPA 4AIGA 1I73A 966CA 4J4MA 1CAQA 1L6JA 1WNIA 3LGPA 1KAPP 1KUHA 3WV2A 1QUAA 3ELMA 1FLSA 2OW9A 1AKLA 1D5JA 5BOTA 4H1QA 2YB9A 1SMPA 3EDGA 1ZXVA 4ILWD 1BIWA 2OY2A 4PKVA 1BM6A 1JAPA 3MA2A 1PWWA 1JKYA 5I3MA 1YQYA 4H3XA 3HY7A 4H49A 2O36A 3WV1A 4I35A 2ERQA 4GR0A 4JP4A 1UEAA 3LJGA 1CGEA 4ZR5A 3KECA 3LKAA 1XFZA 2JSDA 1Y0VA 3USNA 1QJJA 1OS9A 3KEJA 1HOVA 1S4BP 1CQRA 3O2XA 3DSLA 4H82A 2E3XA 1GE6A 3LK8A 5B5PA 3WV3A 1FM1A 2X3BA 1I1IP 5D2BA 2MZIA 1Y8JA 1BKCE 2QPJA 3VI1A 4JQGA 2OXZA 4GR8A 1R1JA 2D1OA 1XM5A 1JAOA 1CXVA 1Z3JA 4PKTA 1BQQM 1GO7P 2OW2A 2FV9A 2CKIA 1OM6A 1EAKA 3N2VA 3Q2HA 2MLSA 1KUFA 2K9CA 1XFWA 1J7NA 3F16A 2OW1A 1CGLA 1KUIA 1IAAA 2KRJA 4A7BA 5LABA 1KBCA 3K7LA 5CZMA 1SRPA 4XBHA 3TS4A 3B92A 1XFXA 2K2GA 2Z2DA 1BKCA 2X7MA 1K7QA 1PWUA 1O0QA 3DTEA 1K7IA 3HDAP 1BUVM 1XUDA 1R55A 4WZVA 2DW2A 2USNA 2MZHA
chains in the Genus database with same CATH topology
1BQOA 2W13A 4AXQA 1RM8A 4JIJA 2E2DA 1OMJA 4I03A 1SU3A 2XS4A 3P1VA 1YP1A 2N8RA 1A85A 4CTHA 3KEKA 3F17A 1MMRA 3O64A 3LIKA 1JK3A 2SRTA 1XUCA 3LILA 3LE9A 2EROA 1ROSA 3P24A 1AF0A 3DL1A 3HDBA 4PKUA 4GQLA 4GF1A 1CIZA 2W12A 1OO9A 4IJOA 4WKEA 3L0TA 4GUYA 3G42A 1GE7A 4L6TA 4XCTA 1XFVA 1G4KA 1FBLA 1SATA 2OW0A 3SHIA 1UMTA 3ZUKA 3RTTA 3VTGA 5I4OA 4DF9A 1JIWP 1R1IA 1PWQA 5I2ZA 3Q2GA 2AYKA 2JNPA 4FXYP 3TT4A 456CA 1JAQA 1QJIA 3I7IA 3L0VA 1JIZA 4WK7A 3EDHA 5D1UA 1HY7A 1IAGA 4JPAA 1OM8A 1EUBA 2PJTA 1ATLA 1BSWA 2JT6A 3LIRA 2RJQA 1USNA 1DMTA 4XM7A 1ZP5A 3E8RA 2DDYA 2AIGP 3DNGA 1OM7A 1SLNA 3AYUA 3DWBA 4DV8A 3EWJA 5JMYA 1HV5A 830CA 2X3AA 3LJZA 1PWPA 3HYGA 3F1AA 3KHIA 3G5CA 3LJTA 4FU4A 4H30A 1HFCA 1IACA 5I43A 4FVLA 3ZXHA 3LQBA 3OHLA 1ASTA 3N2UA 2WO8A 1OS2A 1O0TA 2OXUA 2W14A 3EDZA 1JH1A 2FV5A 1MMQA 3F15A 1XURA 2V4BA 1YOUA 3V96B 3KRYA 2JT5A 3NX7A 1CGFA 3DTKA 4ON1A 3B8ZA 5D1SA 4Q1LA 1UTZA 1RMZA 4WKIA 5I12A 3F18A 3ZVSA 5D7WA 1C8TA 5BOYA 1A86A 4AYKA 5BPAA 4FXQA 3KMCA 3KWVC 3K7NA 1IAEA 4L63A 4DD8A 3HY9A 3HBVP 2MZEA 3LMCA 1K7GA 4H2EA 4AUOA 4A3WA 4G0DA 3U1RA 4XM8A 3RTSA 1G12A 2L0RA 2XS3A 2CLTA 1JANA 2TCLA 2YUFA 3EHXA 1R54A 5D1TA 5CUHA 1B3DA 1HTDA 4EFSA 1C7KA 1QICA 2OVXA 1DTHA 3LUMA 4HX3A 1UTTA 4GWNA 4XM6A 2O3EA 2OXWA 1D8FA 3DPFA 1G9KA 3DPEA 2WOAA 1GE5A 1CK7A 3I7GA 1GKCA 2Y6CA 1GKDA 1GXDA 4WF6A 1MMPA 3AYKA 2MLRA 2J0TA 5CXAA 1XFYA 3LEAA 2HU6A 1C3IA 3GBOA 4R3VA 3TSKA 2D1NA 3B2ZA 1QIAA 5L79A 1ZTQA 3HB2P 4DPEA 1YCMA 1G05A 1B8YA 4GWMA 2OY4A 4IN9A 1BZSA 1BKCI 1Y93A 1KUGA 1D8MA 5D3CA 2YIGA 1KUKA 2OVZA 4H76A 4H84A 3LUNA 1ZXCA 4PKSA 3UVCA 3EDIA 1XFUA 2A8HA 2DW1A 3LQ0A 1H71P 2J83A 1QIBA 1I76A 4QKZA 1R1HA 5B5OA 1GO8P 4L19A 1UMSA 1IADA 2DDFA 1JJ9A 2OZRA 2I47A 4GR3A 1MMBA 3BA0A 3DTIA 1HFSA 2ERPA 4PKWA 1BUDA 1SLMA 3CKIA 2X3CA 1PWVA 1ZS0A 5H8XA 2W0DA 1D7XA 3HBUP 1ND1A 2W15A 4JA1A 3TVCA 1AYKA 3F19A 4PKRA 3EHYA 1ZVXA 1EB6A 1G49A 1MNCA 1Q3AA 2Y6DA 3OHOA 2OI0A 4PKQA 3AIGA 4G9LA 4IUWA 3KMEA 5I0LA 2DW0A 2WO9A 1IABA 4L7AA 5L7FA 4HMAA 2POJA 2JIHA 2RJPA 4AIGA 1I73A 966CA 4J4MA 1CAQA 1L6JA 1WNIA 3LGPA 1KAPP 1KUHA 3WV2A 1QUAA 3ELMA 1FLSA 2OW9A 1AKLA 1D5JA 5BOTA 4H1QA 2YB9A 1SMPA 3EDGA 1ZXVA 4ILWD 1BIWA 2OY2A 4PKVA 1BM6A 1JAPA 3MA2A 1PWWA 1JKYA 5I3MA 1YQYA 4H3XA 3HY7A 4H49A 2O36A 3WV1A 4I35A 2ERQA 4GR0A 4JP4A 1UEAA 3LJGA 1CGEA 4ZR5A 3KECA 3LKAA 1XFZA 2JSDA 1Y0VA 3USNA 1QJJA 1OS9A 3KEJA 1HOVA 1S4BP 1CQRA 3O2XA 3DSLA 4H82A 2E3XA 1GE6A 3LK8A 5B5PA 3WV3A 1FM1A 2X3BA 1I1IP 5D2BA 2MZIA 1Y8JA 1BKCE 2QPJA 3VI1A 4JQGA 2OXZA 4GR8A 1R1JA 2D1OA 1JAOA 1CXVA 1Z3JA 4PKTA 1BQQM 1GO7P 2OW2A 2FV9A 2CKIA 1OM6A 1EAKA 3N2VA 3Q2HA 2MLSA 1KUFA 2K9CA 1XFWA 1J7NA 3F16A 2OW1A 1CGLA 1KUIA 1IAAA 2KRJA 4A7BA 5LABA 1KBCA 3K7LA 5CZMA 1SRPA 4XBHA 3TS4A 3B92A 1XFXA 2K2GA 2Z2DA 1BKCA 2X7MA 1K7QA 1PWUA 1O0QA 3DTEA 1K7IA 3HDAP 1BUVM 1XUDA 1R55A 4WZVA 2DW2A 2USNA 2MZHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BQO A;  2W13 A;  4AXQ A;  1RM8 A;  4JIJ A;  2E2D A;  1OMJ A;  4I03 A;  1SU3 A;  2XS4 A;  3P1V A;  1YP1 A;  2N8R A;  1A85 A;  4CTH A;  3KEK A;  3F17 A;  1MMR A;  3O64 A;  3LIK A;  1JK3 A;  2SRT A;  1XUC A;  3LIL A;  3LE9 A;  2ERO A;  1ROS A;  3P24 A;  1AF0 A;  3DL1 A;  3HDB A;  4PKU A;  4GQL A;  4GF1 A;  1CIZ A;  2W12 A;  1OO9 A;  4IJO A;  4WKE A;  3L0T A;  4GUY A;  3G42 A;  1GE7 A;  4L6T A;  4XCT A;  1XFV A;  1G4K A;  1FBL A;  1SAT A;  2OW0 A;  3SHI A;  1UMT A;  3ZUK A;  3RTT A;  3VTG A;  5I4O A;  4DF9 A;  1JIW P;  1R1I A;  1PWQ A;  5I2Z A;  3Q2G A;  2AYK A;  2JNP A;  4FXY P;  3TT4 A;  456C A;  1JAQ A;  1QJI A;  3I7I A;  3L0V A;  1JIZ A;  4WK7 A;  3EDH A;  5D1U A;  1HY7 A;  1IAG A;  4JPA A;  1OM8 A;  1EUB A;  2PJT A;  1ATL A;  1BSW A;  2JT6 A;  3LIR A;  2RJQ A;  1USN A;  1DMT A;  4XM7 A;  1ZP5 A;  3E8R A;  2DDY A;  2AIG P;  3DNG A;  1OM7 A;  1SLN A;  3AYU A;  3DWB A;  4DV8 A;  3EWJ A;  5JMY A;  1HV5 A;  830C A;  2X3A A;  3LJZ A;  1PWP A;  3HYG A;  3F1A A;  3KHI A;  3G5C A;  3LJT A;  4FU4 A;  4H30 A;  1HFC A;  1IAC A;  5I43 A;  4FVL A;  3ZXH A;  3LQB A;  3OHL A;  1AST A;  3N2U A;  2WO8 A;  1OS2 A;  1O0T A;  2OXU A;  2W14 A;  3EDZ A;  1JH1 A;  2FV5 A;  1MMQ A;  3F15 A;  1XUR A;  2V4B A;  1YOU A;  3V96 B;  3KRY A;  2JT5 A;  3NX7 A;  1CGF A;  4ON1 A;  3B8Z A;  5D1S A;  4Q1L A;  1UTZ A;  1RMZ A;  4WKI A;  5I12 A;  3F18 A;  3ZVS A;  5D7W A;  1C8T A;  5BOY A;  1A86 A;  4AYK A;  5BPA A;  4FXQ A;  3KMC A;  3KWV C;  3K7N A;  1IAE A;  4L63 A;  4DD8 A;  3HY9 A;  3HBV P;  2MZE A;  3LMC A;  1K7G A;  4H2E A;  4AUO A;  4A3W A;  4G0D A;  3U1R A;  4XM8 A;  3RTS A;  1G12 A;  2L0R A;  2XS3 A;  2CLT A;  1JAN A;  2TCL A;  3EHX A;  1R54 A;  5D1T A;  5CUH A;  1B3D A;  1HTD A;  4EFS A;  1C7K A;  1QIC A;  2OVX A;  1DTH A;  3LUM A;  4HX3 A;  1UTT A;  4GWN A;  4XM6 A;  2O3E A;  2OXW A;  1D8F A;  3DPF A;  1G9K A;  3DPE A;  2WOA A;  1GE5 A;  1CK7 A;  3I7G A;  1GKC A;  2Y6C A;  1GKD A;  1GXD A;  4WF6 A;  1MMP A;  3AYK A;  2MLR A;  2J0T A;  5CXA A;  1XFY A;  3LEA A;  2HU6 A;  1C3I A;  3GBO A;  4R3V A;  3TSK A;  2D1N A;  3B2Z A;  1QIA A;  5L79 A;  1ZTQ A;  3HB2 P;  4DPE A;  1YCM A;  1G05 A;  1B8Y A;  4GWM A;  2OY4 A;  4IN9 A;  1BZS A;  1BKC I;  1Y93 A;  1KUG A;  1D8M A;  5D3C A;  2YIG A;  1KUK A;  2OVZ A;  4H76 A;  4H84 A;  3LUN A;  1ZXC A;  4PKS A;  3UVC A;  3EDI A;  1XFU A;  2A8H A;  2DW1 A;  3LQ0 A;  1H71 P;  2J83 A;  1QIB A;  1I76 A;  4QKZ A;  1R1H A;  5B5O A;  1GO8 P;  4L19 A;  1UMS A;  1IAD A;  2DDF A;  1JJ9 A;  2OZR A;  2I47 A;  4GR3 A;  1MMB A;  3BA0 A;  1HFS A;  2ERP A;  4PKW A;  1BUD A;  1SLM A;  3CKI A;  2X3C A;  1PWV A;  1ZS0 A;  5H8X A;  2W0D A;  1D7X A;  3HBU P;  1ND1 A;  2W15 A;  4JA1 A;  3TVC A;  1AYK A;  3F19 A;  4PKR A;  3EHY A;  1ZVX A;  1EB6 A;  1G49 A;  1MNC A;  1Q3A A;  2Y6D A;  3OHO A;  2OI0 A;  4PKQ A;  3AIG A;  4G9L A;  4IUW A;  3KME A;  5I0L A;  2DW0 A;  2WO9 A;  1IAB A;  5L7F A;  4HMA A;  2POJ A;  2JIH A;  2RJP A;  4AIG A;  1I73 A;  966C A;  4J4M A;  1CAQ A;  3LGP A;  1L6J A;  1WNI A;  1KAP P;  1KUH A;  3WV2 A;  1QUA A;  3ELM A;  1FLS A;  2OW9 A;  1AKL A;  1D5J A;  5BOT A;  4H1Q A;  2YB9 A;  1SMP A;  3EDG A;  1ZXV A;  4ILW D;  1BIW A;  2OY2 A;  4PKV A;  1BM6 A;  1JAP A;  3MA2 A;  1PWW A;  1JKY A;  5I3M A;  1YQY A;  4H3X A;  3HY7 A;  4H49 A;  2O36 A;  3WV1 A;  4I35 A;  2ERQ A;  4GR0 A;  4JP4 A;  1UEA A;  3LJG A;  1CGE A;  4ZR5 A;  3KEC A;  3LKA A;  1XFZ A;  2JSD A;  1Y0V A;  3USN A;  1QJJ A;  1OS9 A;  3KEJ A;  1HOV A;  1S4B P;  1CQR A;  3O2X A;  3DSL A;  4H82 A;  2E3X A;  1GE6 A;  3LK8 A;  5B5P A;  3WV3 A;  1FM1 A;  2X3B A;  1I1I P;  5D2B A;  2MZI A;  1Y8J A;  1BKC E;  2QPJ A;  3VI1 A;  4JQG A;  2OXZ A;  4GR8 A;  1R1J A;  2D1O A;  1JAO A;  1CXV A;  1Z3J A;  4PKT A;  1BQQ M;  1GO7 P;  2OW2 A;  2FV9 A;  2CKI A;  1OM6 A;  1EAK A;  3N2V A;  3Q2H A;  2MLS A;  1KUF A;  2K9C A;  1XFW A;  1J7N A;  3F16 A;  2OW1 A;  1CGL A;  1KUI A;  1IAA A;  2KRJ A;  4A7B A;  5LAB A;  1KBC A;  3K7L A;  5CZM A;  1SRP A;  4XBH A;  3TS4 A;  3B92 A;  1XFX A;  2K2G A;  2Z2D A;  1BKC A;  2X7M A;  1K7Q A;  1PWU A;  1O0Q A;  1K7I A;  3HDA P;  1BUV M;  1XUD A;  1R55 A;  4WZV A;  2DW2 A;  2USN A;  2MZH A; 
#chains in the Genus database with same CATH topology
 1BQO A;  2W13 A;  4AXQ A;  1RM8 A;  4JIJ A;  2E2D A;  1OMJ A;  4I03 A;  1SU3 A;  2XS4 A;  3P1V A;  1YP1 A;  2N8R A;  1A85 A;  4CTH A;  3KEK A;  3F17 A;  1MMR A;  3O64 A;  3LIK A;  1JK3 A;  2SRT A;  1XUC A;  3LIL A;  3LE9 A;  2ERO A;  1ROS A;  3P24 A;  1AF0 A;  3DL1 A;  3HDB A;  4PKU A;  4GQL A;  4GF1 A;  1CIZ A;  2W12 A;  1OO9 A;  4IJO A;  4WKE A;  3L0T A;  4GUY A;  3G42 A;  1GE7 A;  4L6T A;  4XCT A;  1XFV A;  1G4K A;  1FBL A;  1SAT A;  2OW0 A;  3SHI A;  1UMT A;  3ZUK A;  3RTT A;  3VTG A;  5I4O A;  4DF9 A;  1JIW P;  1R1I A;  1PWQ A;  5I2Z A;  3Q2G A;  2AYK A;  2JNP A;  4FXY P;  3TT4 A;  456C A;  1JAQ A;  1QJI A;  3I7I A;  3L0V A;  1JIZ A;  4WK7 A;  3EDH A;  5D1U A;  1HY7 A;  1IAG A;  4JPA A;  1OM8 A;  1EUB A;  2PJT A;  1ATL A;  1BSW A;  2JT6 A;  3LIR A;  2RJQ A;  1USN A;  1DMT A;  4XM7 A;  1ZP5 A;  3E8R A;  2DDY A;  2AIG P;  3DNG A;  1XAX A;  1OM7 A;  1SLN A;  3AYU A;  3DWB A;  4DV8 A;  3EWJ A;  5JMY A;  1HV5 A;  830C A;  1OZ9 A;  2X3A A;  3LJZ A;  1PWP A;  3HYG A;  3F1A A;  3KHI A;  3G5C A;  3LJT A;  4FU4 A;  4H30 A;  1HFC A;  1IAC A;  5I43 A;  4FVL A;  3ZXH A;  3LQB A;  3OHL A;  1AST A;  3N2U A;  2WO8 A;  1OS2 A;  1O0T A;  2OXU A;  2W14 A;  3EDZ A;  1JH1 A;  2FV5 A;  1MMQ A;  3F15 A;  1XUR A;  2V4B A;  1YOU A;  3V96 B;  3KRY A;  2JT5 A;  3NX7 A;  1CGF A;  3DTK A;  4ON1 A;  3B8Z A;  5D1S A;  4Q1L A;  1UTZ A;  1RMZ A;  4WKI A;  5I12 A;  3F18 A;  3ZVS A;  5D7W A;  1C8T A;  5BOY A;  1A86 A;  4AYK A;  5BPA A;  4FXQ A;  3KMC A;  3KWV C;  3K7N A;  1IAE A;  4L63 A;  4DD8 A;  3HY9 A;  3HBV P;  2MZE A;  3LMC A;  1K7G A;  4H2E A;  4AUO A;  4A3W A;  4G0D A;  3U1R A;  4XM8 A;  3RTS A;  1TVI A;  1G12 A;  2L0R A;  2XS3 A;  2CLT A;  1JAN A;  2TCL A;  2YUF A;  3EHX A;  1R54 A;  5D1T A;  5CUH A;  1B3D A;  1HTD A;  4EFS A;  1C7K A;  1QIC A;  2OVX A;  1DTH A;  3LUM A;  4HX3 A;  1UTT A;  4GWN A;  4XM6 A;  2O3E A;  2OXW A;  1D8F A;  3DPF A;  1G9K A;  3DPE A;  2WOA A;  1GE5 A;  1CK7 A;  3I7G A;  1GKC A;  2Y6C A;  1GKD A;  1GXD A;  4WF6 A;  1MMP A;  3AYK A;  2MLR A;  2J0T A;  5CXA A;  1XFY A;  3LEA A;  2HU6 A;  1C3I A;  3GBO A;  4R3V A;  3TSK A;  2D1N A;  3B2Z A;  1QIA A;  5L79 A;  1ZTQ A;  3HB2 P;  4DPE A;  1YCM A;  1G05 A;  1B8Y A;  4GWM A;  2OY4 A;  4IN9 A;  1BZS A;  1BKC I;  1Y93 A;  1KUG A;  1D8M A;  5D3C A;  2YIG A;  1KUK A;  2OVZ A;  4H76 A;  4H84 A;  3LUN A;  1ZXC A;  4PKS A;  3UVC A;  3EDI A;  1XFU A;  2A8H A;  2DW1 A;  3LQ0 A;  1H71 P;  2J83 A;  1QIB A;  1I76 A;  4QKZ A;  1R1H A;  5B5O A;  1GO8 P;  4L19 A;  1UMS A;  1IAD A;  2DDF A;  1JJ9 A;  2OZR A;  2I47 A;  4GR3 A;  1MMB A;  3BA0 A;  3DTI A;  1HFS A;  2ERP A;  4PKW A;  1BUD A;  1SLM A;  3CKI A;  2X3C A;  1PWV A;  1ZS0 A;  5H8X A;  2W0D A;  1D7X A;  3HBU P;  1ND1 A;  2W15 A;  4JA1 A;  3TVC A;  1AYK A;  3F19 A;  4PKR A;  3EHY A;  1ZVX A;  1EB6 A;  1G49 A;  1MNC A;  1Q3A A;  2Y6D A;  3OHO A;  2OI0 A;  4PKQ A;  3AIG A;  4G9L A;  4IUW A;  3KME A;  5I0L A;  2DW0 A;  2WO9 A;  1IAB A;  4L7A A;  5L7F A;  4HMA A;  2POJ A;  2JIH A;  2RJP A;  4AIG A;  1I73 A;  966C A;  4J4M A;  1CAQ A;  1L6J A;  1WNI A;  3LGP A;  1KAP P;  1KUH A;  3WV2 A;  1QUA A;  3ELM A;  1FLS A;  2OW9 A;  1AKL A;  1D5J A;  5BOT A;  4H1Q A;  2YB9 A;  1SMP A;  3EDG A;  1ZXV A;  4ILW D;  1BIW A;  2OY2 A;  4PKV A;  1BM6 A;  1JAP A;  3MA2 A;  1PWW A;  1JKY A;  5I3M A;  1YQY A;  4H3X A;  3HY7 A;  4H49 A;  2O36 A;  3WV1 A;  4I35 A;  2ERQ A;  4GR0 A;  4JP4 A;  1UEA A;  3LJG A;  1CGE A;  4ZR5 A;  3KEC A;  3LKA A;  1XFZ A;  2JSD A;  1Y0V A;  3USN A;  1QJJ A;  1OS9 A;  3KEJ A;  1HOV A;  1S4B P;  1CQR A;  3O2X A;  3DSL A;  4H82 A;  2E3X A;  1GE6 A;  3LK8 A;  5B5P A;  3WV3 A;  1FM1 A;  2X3B A;  1I1I P;  5D2B A;  2MZI A;  1Y8J A;  1BKC E;  2QPJ A;  3VI1 A;  4JQG A;  2OXZ A;  4GR8 A;  1R1J A;  2D1O A;  1XM5 A;  1JAO A;  1CXV A;  1Z3J A;  4PKT A;  1BQQ M;  1GO7 P;  2OW2 A;  2FV9 A;  2CKI A;  1OM6 A;  1EAK A;  3N2V A;  3Q2H A;  2MLS A;  1KUF A;  2K9C A;  1XFW A;  1J7N A;  3F16 A;  2OW1 A;  1CGL A;  1KUI A;  1IAA A;  2KRJ A;  4A7B A;  5LAB A;  1KBC A;  3K7L A;  5CZM A;  1SRP A;  4XBH A;  3TS4 A;  3B92 A;  1XFX A;  2K2G A;  2Z2D A;  1BKC A;  2X7M A;  1K7Q A;  1PWU A;  1O0Q A;  3DTE A;  1K7I A;  3HDA P;  1BUV M;  1XUD A;  1R55 A;  4WZV A;  2DW2 A;  2USN A;  2MZH A; 
#chains in the Genus database with same CATH homology
 1BQO A;  2W13 A;  4AXQ A;  1RM8 A;  4JIJ A;  2E2D A;  1OMJ A;  4I03 A;  1SU3 A;  2XS4 A;  3P1V A;  1YP1 A;  2N8R A;  1A85 A;  4CTH A;  3KEK A;  3F17 A;  1MMR A;  3O64 A;  3LIK A;  1JK3 A;  2SRT A;  1XUC A;  3LIL A;  3LE9 A;  2ERO A;  1ROS A;  3P24 A;  1AF0 A;  3DL1 A;  3HDB A;  4PKU A;  4GQL A;  4GF1 A;  1CIZ A;  2W12 A;  1OO9 A;  4IJO A;  4WKE A;  3L0T A;  4GUY A;  3G42 A;  1GE7 A;  4L6T A;  4XCT A;  1XFV A;  1G4K A;  1FBL A;  1SAT A;  2OW0 A;  3SHI A;  1UMT A;  3ZUK A;  3RTT A;  3VTG A;  5I4O A;  4DF9 A;  1JIW P;  1R1I A;  1PWQ A;  5I2Z A;  3Q2G A;  2AYK A;  2JNP A;  4FXY P;  3TT4 A;  456C A;  1JAQ A;  1QJI A;  3I7I A;  3L0V A;  1JIZ A;  4WK7 A;  3EDH A;  5D1U A;  1HY7 A;  1IAG A;  4JPA A;  1OM8 A;  1EUB A;  2PJT A;  1ATL A;  1BSW A;  2JT6 A;  3LIR A;  2RJQ A;  1USN A;  1DMT A;  4XM7 A;  1ZP5 A;  3E8R A;  2DDY A;  2AIG P;  3DNG A;  1OM7 A;  1SLN A;  3AYU A;  3DWB A;  4DV8 A;  3EWJ A;  5JMY A;  1HV5 A;  830C A;  2X3A A;  3LJZ A;  1PWP A;  3HYG A;  3F1A A;  3KHI A;  3G5C A;  3LJT A;  4FU4 A;  4H30 A;  1HFC A;  1IAC A;  5I43 A;  4FVL A;  3ZXH A;  3LQB A;  3OHL A;  1AST A;  3N2U A;  2WO8 A;  1OS2 A;  1O0T A;  2OXU A;  2W14 A;  3EDZ A;  1JH1 A;  2FV5 A;  1MMQ A;  3F15 A;  1XUR A;  2V4B A;  1YOU A;  3V96 B;  3KRY A;  2JT5 A;  3NX7 A;  1CGF A;  3DTK A;  4ON1 A;  3B8Z A;  5D1S A;  4Q1L A;  1UTZ A;  1RMZ A;  4WKI A;  5I12 A;  3F18 A;  3ZVS A;  5D7W A;  1C8T A;  5BOY A;  1A86 A;  4AYK A;  5BPA A;  4FXQ A;  3KMC A;  3KWV C;  3K7N A;  1IAE A;  4L63 A;  4DD8 A;  3HY9 A;  3HBV P;  2MZE A;  3LMC A;  1K7G A;  4H2E A;  4AUO A;  4A3W A;  4G0D A;  3U1R A;  4XM8 A;  3RTS A;  1G12 A;  2L0R A;  2XS3 A;  2CLT A;  1JAN A;  2TCL A;  2YUF A;  3EHX A;  1R54 A;  5D1T A;  5CUH A;  1B3D A;  1HTD A;  4EFS A;  1C7K A;  1QIC A;  2OVX A;  1DTH A;  3LUM A;  4HX3 A;  1UTT A;  4GWN A;  4XM6 A;  2O3E A;  2OXW A;  1D8F A;  3DPF A;  1G9K A;  3DPE A;  2WOA A;  1GE5 A;  1CK7 A;  3I7G A;  1GKC A;  2Y6C A;  1GKD A;  1GXD A;  4WF6 A;  1MMP A;  3AYK A;  2MLR A;  2J0T A;  5CXA A;  1XFY A;  3LEA A;  2HU6 A;  1C3I A;  3GBO A;  4R3V A;  3TSK A;  2D1N A;  3B2Z A;  1QIA A;  5L79 A;  1ZTQ A;  3HB2 P;  4DPE A;  1YCM A;  1G05 A;  1B8Y A;  4GWM A;  2OY4 A;  4IN9 A;  1BZS A;  1BKC I;  1Y93 A;  1KUG A;  1D8M A;  5D3C A;  2YIG A;  1KUK A;  2OVZ A;  4H76 A;  4H84 A;  3LUN A;  1ZXC A;  4PKS A;  3UVC A;  3EDI A;  1XFU A;  2A8H A;  2DW1 A;  3LQ0 A;  1H71 P;  2J83 A;  1QIB A;  1I76 A;  4QKZ A;  1R1H A;  5B5O A;  1GO8 P;  4L19 A;  1UMS A;  1IAD A;  2DDF A;  1JJ9 A;  2OZR A;  2I47 A;  4GR3 A;  1MMB A;  3BA0 A;  3DTI A;  1HFS A;  2ERP A;  4PKW A;  1BUD A;  1SLM A;  3CKI A;  2X3C A;  1PWV A;  1ZS0 A;  5H8X A;  2W0D A;  1D7X A;  3HBU P;  1ND1 A;  2W15 A;  4JA1 A;  3TVC A;  1AYK A;  3F19 A;  4PKR A;  3EHY A;  1ZVX A;  1EB6 A;  1G49 A;  1MNC A;  1Q3A A;  2Y6D A;  3OHO A;  2OI0 A;  4PKQ A;  3AIG A;  4G9L A;  4IUW A;  3KME A;  5I0L A;  2DW0 A;  2WO9 A;  1IAB A;  4L7A A;  5L7F A;  4HMA A;  2POJ A;  2JIH A;  2RJP A;  4AIG A;  1I73 A;  966C A;  4J4M A;  1CAQ A;  1L6J A;  1WNI A;  3LGP A;  1KAP P;  1KUH A;  3WV2 A;  1QUA A;  3ELM A;  1FLS A;  2OW9 A;  1AKL A;  1D5J A;  5BOT A;  4H1Q A;  2YB9 A;  1SMP A;  3EDG A;  1ZXV A;  4ILW D;  1BIW A;  2OY2 A;  4PKV A;  1BM6 A;  1JAP A;  3MA2 A;  1PWW A;  1JKY A;  5I3M A;  1YQY A;  4H3X A;  3HY7 A;  4H49 A;  2O36 A;  3WV1 A;  4I35 A;  2ERQ A;  4GR0 A;  4JP4 A;  1UEA A;  3LJG A;  1CGE A;  4ZR5 A;  3KEC A;  3LKA A;  1XFZ A;  2JSD A;  1Y0V A;  3USN A;  1QJJ A;  1OS9 A;  3KEJ A;  1HOV A;  1S4B P;  1CQR A;  3O2X A;  3DSL A;  4H82 A;  2E3X A;  1GE6 A;  3LK8 A;  5B5P A;  3WV3 A;  1FM1 A;  2X3B A;  1I1I P;  5D2B A;  2MZI A;  1Y8J A;  1BKC E;  2QPJ A;  3VI1 A;  4JQG A;  2OXZ A;  4GR8 A;  1R1J A;  2D1O A;  1JAO A;  1CXV A;  1Z3J A;  4PKT A;  1BQQ M;  1GO7 P;  2OW2 A;  2FV9 A;  2CKI A;  1OM6 A;  1EAK A;  3N2V A;  3Q2H A;  2MLS A;  1KUF A;  2K9C A;  1XFW A;  1J7N A;  3F16 A;  2OW1 A;  1CGL A;  1KUI A;  1IAA A;  2KRJ A;  4A7B A;  5LAB A;  1KBC A;  3K7L A;  5CZM A;  1SRP A;  4XBH A;  3TS4 A;  3B92 A;  1XFX A;  2K2G A;  2Z2D A;  1BKC A;  2X7M A;  1K7Q A;  1PWU A;  1O0Q A;  3DTE A;  1K7I A;  3HDA P;  1BUV M;  1XUD A;  1R55 A;  4WZV A;  2DW2 A;  2USN A;  2MZH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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