3HY9A

Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
217
structure length
217
Chain Sequence
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
pubmed doi rcsb
molecule keywords Catalytic Domain of ADAMTS-5
total genus 74
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2009-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3hy9A00
1SLMA 4XM7A 3MA2A 5D2BA 1BM6A 2L0RA 1ATLA 1OMJA 1AKLA 5CXAA 3HYGA 1GO7P 2OY4A 3AIGA 1CXVA 3V96B 2USNA 4FXQA 2MZIA 3LGPA 1KBCA 4H30A 2KRJA 3DPEA 3LKAA 1EAKA 3TS4A 4FVLA 1JH1A 5I2ZA 1PWPA 1J7NA 2K9CA 1D5JA 3WV3A 2WOAA 1ROSA 2W15A 3AYKA 2X3AA 1CK7A 2OW9A 4I03A 4ZR5A 4GR0A 1WNIA 1SRPA 4PKQA 4IUWA 2OI0A 4WF6A 5I3MA 1MMQA 1HFCA 4JIJA 2Y6CA 3F19A 1GXDA 1BZSA 4PKRA 5B5PA 1IAGA 4H82A 1OM8A 2MLRA 3TSKA 3I7GA 3AYUA 3CKIA 3EDZA 1OS9A 4H3XA 4I35A 1CIZA 1MMRA 4XM6A 1I73A 2EROA 4XBHA 4PKVA 1ASTA 2POJA 1AYKA 3B2ZA 1R55A 3LIRA 1JK3A 2E2DA 1Y8JA 1I76A 2W0DA 2D1OA 1RMZA 1PWQA 1O0QA 3VTGA 4DPEA 1K7GA 1C8TA 2MZHA 1MNCA 3EDIA 2J83A 3B92A 5BPAA 5I4OA 1CGEA 4Q1LA 3K7LA 1OM6A 2XS4A 2JT5A 3TVCA 2D1NA 1UTZA 1SATA 3KMCA 2W13A 4DV8A 5JMYA 4IJOA 1UMSA 1GKDA 1OO9A 1BUDA 2RJPA 3ZUKA 1BUVM 2N8RA 4H2EA 3LUNA 2O3EA 3KHIA 1Y93A 4WKEA 1IAEA 2OZRA 1BQOA 2OW2A 3EHXA 1JAPA 3K7NA 3ZXHA 1IADA 4GQLA 1ZP5A 3F15A 1C7KA 3O2XA 1G05A 4WK7A 1JANA 4L63A 4WKIA 1OM7A 3EHYA 1XFZA 2Z2DA 4EFSA 2CKIA 3OHOA 1I1IP 3HBVP 1ZTQA 3HDBA 1HY7A 5CZMA 3Q2GA 3HB2P 3WV1A 4PKSA 1JAQA 1DTHA 3U1RA 3DSLA 5D1UA 4G9LA 1KUKA 3SHIA 3F1AA 4HX3A 2RJQA 2X3BA 1QJJA 4JP4A 1R1IA 3DWBA 4R3VA 1SMPA 1Q3AA 1KUGA 5CUHA 4GUYA 2OXWA 2MZEA 1PWUA 4AYKA 3P24A 3I7IA 3EDGA 1BIWA 4H49A 3LMCA 4A3WA 2CLTA 1S4BP 456CA 1XFVA 4J4MA 4DF9A 1CGFA 1Y0VA 1C3IA 1BKCI 2ERPA 1KUFA 2FV9A 2OW0A 1OS2A 1H71P 4A7BA 1IACA 1CQRA 5L7FA 1A85A 1GO8P 2V4BA 4CTHA 1AF0A 1KUIA 1XURA 1JKYA 1BQQM 4XCTA 3G42A 1FBLA 4FU4A 1KAPP 1B8YA 1JIZA 1YP1A 2I47A 2WO8A 3ZVSA 2X3CA 3O64A 1XFXA 4L6TA 1BSWA 3HBUP 2DDFA 5I0LA 5L79A 1D7XA 1L6JA 4PKUA 3N2UA 3KWVC 3LQ0A 2J0TA 2JT6A 3ELMA 4L19A 1SLNA 1JJ9A 2WO9A 1UMTA 2W14A 1HFSA 1K7IA 2W12A 2OVXA 3LJZA 2OXUA 3LEAA 2OW1A 2DW1A 4GWNA 3EDHA 1KUHA 3F16A 1USNA 1YQYA 4G0DA 1JAOA 3RTTA 1PWVA 3USNA 4JPAA 2K2GA 3KMEA 3DNGA 1ZXVA 2TCLA 966CA 1SU3A 1QIBA 1G49A 3VI1A 1GKCA 2AYKA 1CGLA 3KECA 1FLSA 1UTTA 3GBOA 5D7WA 2YIGA 4ILWD 4GF1A 3EWJA 3B8ZA 3L0VA 1GE6A 1UEAA 2DW0A 1FM1A 5BOTA 1QICA 830CA 4PKWA 5D3CA 4AXQA 1GE5A 3BA0A 3HY9A 1G4KA 1QJIA 3LILA 5I12A 2OVZA 4DD8A 1R1JA 2JNPA 1HTDA 1R1HA 4IN9A 1RM8A 4AUOA 1Z3JA 3LQBA 4GR3A 1MMBA 1G9KA 2SRTA 1YCMA 2MLSA 1MMPA 3F18A 4GWMA 4AIGA 3RTSA 4H1QA 3NX7A 1R54A 3KRYA 1K7QA 4PKTA 1XUDA 2AIGP 4WZVA 1XUCA 2X7MA 1EB6A 4XM8A 3N2VA 2A8HA 2JIHA 1ZXCA 2XS3A 1O0TA 4JQGA 1D8FA 2QPJA 4FXYP 5B5OA 1EUBA 2YB9A 2JSDA 3KEKA 1CAQA 4HMAA 3TT4A 3HY7A 1XFYA 3LUMA 2OXZA 4GR8A 1BKCA 1HOVA 3LK8A 1ND1A 2DDYA 2O36A 3E8RA 2E3XA 3G5CA 3L0TA 5D1SA 3Q2HA 1XFUA 1G12A 2ERQA 3LE9A 1ZS0A 1IABA 1ZVXA 2DW2A 2FV5A 4ON1A 3LJGA 4H76A 2HU6A 3UVCA 5I43A 1XFWA 1GE7A 1YOUA 1B3DA 3DL1A 4QKZA 2Y6DA 3P1VA 5D1TA 5H8XA 1A86A 3OHLA 4JA1A 1QUAA 3F17A 1BKCE 1HV5A 3HDAP 1QIAA 1PWWA 3KEJA 1DMTA 2OY2A 1D8MA 3LJTA 1JIWP 1IAAA 5LABA 2PJTA 3LIKA 3DPFA 4H84A 5BOYA 3WV2A
chains in the Genus database with same CATH superfamily
1SLMA 4XM7A 3MA2A 5D2BA 1BM6A 2L0RA 1ATLA 1OMJA 1AKLA 5CXAA 3HYGA 1GO7P 2OY4A 3AIGA 1CXVA 3V96B 2USNA 4FXQA 2MZIA 3LGPA 1KBCA 4H30A 2KRJA 3DPEA 3LKAA 1EAKA 3TS4A 4FVLA 1JH1A 5I2ZA 1PWPA 1J7NA 2K9CA 1D5JA 3WV3A 2WOAA 1ROSA 2W15A 2YUFA 3AYKA 2X3AA 1CK7A 2OW9A 4I03A 4ZR5A 4GR0A 1WNIA 1SRPA 4PKQA 4IUWA 2OI0A 4WF6A 5I3MA 1MMQA 1HFCA 4JIJA 2Y6CA 3F19A 1GXDA 1BZSA 4PKRA 5B5PA 1IAGA 4H82A 1OM8A 2MLRA 3TSKA 3I7GA 3AYUA 3CKIA 3EDZA 1OS9A 4H3XA 4I35A 1CIZA 1MMRA 4XM6A 1I73A 2EROA 4XBHA 4PKVA 1ASTA 2POJA 1AYKA 3B2ZA 1R55A 3LIRA 1JK3A 1XM5A 2E2DA 1Y8JA 1I76A 2W0DA 2D1OA 1RMZA 1PWQA 1O0QA 3VTGA 4DPEA 1K7GA 1C8TA 2MZHA 1MNCA 3EDIA 2J83A 3B92A 5BPAA 5I4OA 1CGEA 4Q1LA 3K7LA 1OM6A 2XS4A 2JT5A 3TVCA 2D1NA 1UTZA 1SATA 3KMCA 2W13A 4DV8A 5JMYA 4IJOA 1UMSA 1GKDA 1OO9A 1BUDA 2RJPA 3ZUKA 1BUVM 2N8RA 4H2EA 3LUNA 2O3EA 3KHIA 1Y93A 4WKEA 1IAEA 2OZRA 1BQOA 2OW2A 3EHXA 1JAPA 3K7NA 3ZXHA 1IADA 4GQLA 1ZP5A 3F15A 1C7KA 3DTEA 3O2XA 1G05A 4WK7A 1JANA 4L63A 4WKIA 1OM7A 3EHYA 1XFZA 2Z2DA 4EFSA 2CKIA 3OHOA 1I1IP 3HBVP 1ZTQA 3HDBA 1HY7A 5CZMA 3Q2GA 3HB2P 3WV1A 4PKSA 1JAQA 1DTHA 3U1RA 3DSLA 5D1UA 4G9LA 1KUKA 3SHIA 3F1AA 4HX3A 2RJQA 2X3BA 1QJJA 4JP4A 1R1IA 3DWBA 4L7AA 4R3VA 1SMPA 1Q3AA 1KUGA 5CUHA 4GUYA 2OXWA 2MZEA 1PWUA 4AYKA 3P24A 3I7IA 3EDGA 1BIWA 4H49A 3LMCA 4A3WA 2CLTA 1S4BP 456CA 1XFVA 4J4MA 4DF9A 1CGFA 1Y0VA 1C3IA 1BKCI 2ERPA 1KUFA 2FV9A 2OW0A 1OS2A 1H71P 4A7BA 1IACA 1CQRA 5L7FA 1A85A 1GO8P 2V4BA 4CTHA 1AF0A 1KUIA 1XURA 1JKYA 1BQQM 4XCTA 3G42A 1FBLA 4FU4A 1KAPP 1B8YA 1JIZA 1YP1A 2I47A 2WO8A 3DTKA 3ZVSA 2X3CA 3O64A 1XFXA 4L6TA 1BSWA 3HBUP 2DDFA 5I0LA 5L79A 1D7XA 1L6JA 4PKUA 3N2UA 3KWVC 3LQ0A 2J0TA 2JT6A 3ELMA 4L19A 1SLNA 1JJ9A 2WO9A 1UMTA 2W14A 1HFSA 1K7IA 2W12A 2OVXA 3LJZA 2OXUA 3LEAA 2OW1A 2DW1A 4GWNA 3EDHA 1KUHA 3F16A 1USNA 1YQYA 4G0DA 1JAOA 3RTTA 1PWVA 3USNA 4JPAA 2K2GA 3KMEA 3DNGA 1ZXVA 2TCLA 966CA 1SU3A 1QIBA 1G49A 3VI1A 1GKCA 2AYKA 1CGLA 3KECA 1FLSA 1UTTA 3GBOA 5D7WA 2YIGA 4ILWD 4GF1A 3EWJA 3B8ZA 3L0VA 1GE6A 1UEAA 2DW0A 1FM1A 5BOTA 1QICA 830CA 4PKWA 5D3CA 4AXQA 1GE5A 3BA0A 3HY9A 3DTIA 1G4KA 1QJIA 3LILA 5I12A 2OVZA 4DD8A 1R1JA 2JNPA 1HTDA 1R1HA 4IN9A 1RM8A 4AUOA 1Z3JA 3LQBA 4GR3A 1XAXA 1MMBA 1G9KA 2SRTA 1YCMA 2MLSA 1MMPA 3F18A 4GWMA 4AIGA 3RTSA 4H1QA 3NX7A 1R54A 3KRYA 1K7QA 4PKTA 1XUDA 2AIGP 4WZVA 1XUCA 2X7MA 1EB6A 4XM8A 3N2VA 2A8HA 2JIHA 1ZXCA 2XS3A 1O0TA 4JQGA 1D8FA 2QPJA 4FXYP 5B5OA 1EUBA 2YB9A 2JSDA 3KEKA 1CAQA 4HMAA 3TT4A 3HY7A 1XFYA 3LUMA 2OXZA 4GR8A 1BKCA 1HOVA 3LK8A 1ND1A 2DDYA 1OZ9A 2O36A 3E8RA 2E3XA 3G5CA 3L0TA 5D1SA 3Q2HA 1XFUA 1G12A 2ERQA 3LE9A 1ZS0A 1IABA 1ZVXA 2DW2A 2FV5A 4ON1A 3LJGA 4H76A 2HU6A 3UVCA 5I43A 1XFWA 1GE7A 1YOUA 1B3DA 3DL1A 4QKZA 2Y6DA 3P1VA 5D1TA 5H8XA 1A86A 3OHLA 4JA1A 1QUAA 3F17A 1BKCE 1HV5A 3HDAP 1QIAA 1PWWA 3KEJA 1TVIA 1DMTA 2OY2A 1D8MA 3LJTA 1JIWP 1IAAA 5LABA 2PJTA 3LIKA 3DPFA 4H84A 5BOYA 3WV2A
chains in the Genus database with same CATH topology
1SLMA 4XM7A 3MA2A 5D2BA 1BM6A 2L0RA 1ATLA 1OMJA 1AKLA 5CXAA 3HYGA 1GO7P 2OY4A 3AIGA 1CXVA 3V96B 2USNA 4FXQA 2MZIA 3LGPA 1KBCA 4H30A 2KRJA 3DPEA 3LKAA 1EAKA 3TS4A 4FVLA 1JH1A 5I2ZA 1PWPA 1J7NA 2K9CA 1D5JA 3WV3A 2WOAA 1ROSA 2W15A 2YUFA 3AYKA 2X3AA 1CK7A 2OW9A 4I03A 4ZR5A 4GR0A 1WNIA 1SRPA 4PKQA 4IUWA 2OI0A 4WF6A 5I3MA 1MMQA 1HFCA 4JIJA 2Y6CA 3F19A 1GXDA 1BZSA 4PKRA 5B5PA 1IAGA 4H82A 1OM8A 2MLRA 3TSKA 3I7GA 3AYUA 3CKIA 3EDZA 1OS9A 4H3XA 4I35A 1CIZA 1MMRA 4XM6A 1I73A 2EROA 4XBHA 4PKVA 1ASTA 2POJA 1AYKA 3B2ZA 1R55A 3LIRA 1JK3A 2E2DA 1Y8JA 1I76A 2W0DA 2D1OA 1RMZA 1PWQA 1O0QA 3VTGA 4DPEA 1K7GA 1C8TA 2MZHA 1MNCA 3EDIA 2J83A 3B92A 5BPAA 5I4OA 1CGEA 4Q1LA 3K7LA 1OM6A 2XS4A 2JT5A 3TVCA 2D1NA 1UTZA 1SATA 3KMCA 2W13A 4DV8A 5JMYA 4IJOA 1UMSA 1GKDA 1OO9A 1BUDA 2RJPA 3ZUKA 1BUVM 2N8RA 4H2EA 3LUNA 2O3EA 3KHIA 1Y93A 4WKEA 1IAEA 2OZRA 1BQOA 2OW2A 3EHXA 1JAPA 3K7NA 3ZXHA 1IADA 4GQLA 1ZP5A 3F15A 1C7KA 3DTEA 3O2XA 1G05A 4WK7A 1JANA 4L63A 4WKIA 1OM7A 3EHYA 1XFZA 2Z2DA 4EFSA 2CKIA 3OHOA 1I1IP 3HBVP 1ZTQA 3HDBA 1HY7A 5CZMA 3Q2GA 3HB2P 3WV1A 4PKSA 1JAQA 1DTHA 3U1RA 3DSLA 5D1UA 4G9LA 1KUKA 3SHIA 3F1AA 4HX3A 2RJQA 2X3BA 1QJJA 4JP4A 1R1IA 3DWBA 4L7AA 4R3VA 1SMPA 1Q3AA 1KUGA 5CUHA 4GUYA 2OXWA 2MZEA 1PWUA 4AYKA 3P24A 3I7IA 3EDGA 1BIWA 4H49A 3LMCA 4A3WA 2CLTA 1S4BP 456CA 1XFVA 4J4MA 4DF9A 1CGFA 1Y0VA 1C3IA 1BKCI 2ERPA 1KUFA 2FV9A 2OW0A 1OS2A 1H71P 4A7BA 1IACA 1CQRA 5L7FA 1A85A 1GO8P 2V4BA 4CTHA 1AF0A 1KUIA 1XURA 1JKYA 1BQQM 4XCTA 3G42A 1FBLA 4FU4A 1KAPP 1B8YA 1JIZA 1YP1A 2I47A 2WO8A 3DTKA 3ZVSA 2X3CA 3O64A 1XFXA 4L6TA 1BSWA 3HBUP 2DDFA 5I0LA 5L79A 1D7XA 1L6JA 4PKUA 3N2UA 3KWVC 3LQ0A 2J0TA 2JT6A 3ELMA 4L19A 1SLNA 1JJ9A 2WO9A 1UMTA 2W14A 1HFSA 1K7IA 2W12A 2OVXA 3LJZA 2OXUA 3LEAA 2OW1A 2DW1A 4GWNA 3EDHA 1KUHA 3F16A 1USNA 1YQYA 4G0DA 1JAOA 3RTTA 1PWVA 3USNA 4JPAA 2K2GA 3KMEA 3DNGA 1ZXVA 2TCLA 966CA 1SU3A 1QIBA 1G49A 3VI1A 1GKCA 2AYKA 1CGLA 3KECA 1FLSA 1UTTA 3GBOA 5D7WA 2YIGA 4ILWD 4GF1A 3EWJA 3B8ZA 3L0VA 1GE6A 1UEAA 2DW0A 1FM1A 5BOTA 1QICA 830CA 4PKWA 5D3CA 4AXQA 1GE5A 3BA0A 3HY9A 3DTIA 1G4KA 1QJIA 3LILA 5I12A 2OVZA 4DD8A 1R1JA 2JNPA 1HTDA 1R1HA 4IN9A 1RM8A 4AUOA 1Z3JA 3LQBA 4GR3A 1MMBA 1G9KA 2SRTA 1YCMA 2MLSA 1MMPA 3F18A 4GWMA 4AIGA 3RTSA 4H1QA 3NX7A 1R54A 3KRYA 1K7QA 4PKTA 1XUDA 2AIGP 4WZVA 1XUCA 2X7MA 1EB6A 4XM8A 3N2VA 2A8HA 2JIHA 1ZXCA 2XS3A 1O0TA 4JQGA 1D8FA 2QPJA 4FXYP 5B5OA 1EUBA 2YB9A 2JSDA 3KEKA 1CAQA 4HMAA 3TT4A 3HY7A 1XFYA 3LUMA 2OXZA 4GR8A 1BKCA 1HOVA 3LK8A 1ND1A 2DDYA 2O36A 3E8RA 2E3XA 3G5CA 3L0TA 5D1SA 3Q2HA 1XFUA 1G12A 2ERQA 3LE9A 1ZS0A 1IABA 1ZVXA 2DW2A 2FV5A 4ON1A 3LJGA 4H76A 2HU6A 3UVCA 5I43A 1XFWA 1GE7A 1YOUA 1B3DA 3DL1A 4QKZA 2Y6DA 3P1VA 5D1TA 5H8XA 1A86A 3OHLA 4JA1A 1QUAA 3F17A 1BKCE 1HV5A 3HDAP 1QIAA 1PWWA 3KEJA 1DMTA 2OY2A 1D8MA 3LJTA 1JIWP 1IAAA 5LABA 2PJTA 3LIKA 3DPFA 4H84A 5BOYA 3WV2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SLM A;  4XM7 A;  3MA2 A;  5D2B A;  1BM6 A;  2L0R A;  1ATL A;  1OMJ A;  1AKL A;  5CXA A;  3HYG A;  1GO7 P;  2OY4 A;  3AIG A;  1CXV A;  3V96 B;  2USN A;  4FXQ A;  2MZI A;  3LGP A;  1KBC A;  4H30 A;  2KRJ A;  3DPE A;  3LKA A;  1EAK A;  3TS4 A;  4FVL A;  1JH1 A;  5I2Z A;  1PWP A;  1J7N A;  2K9C A;  1D5J A;  3WV3 A;  2WOA A;  1ROS A;  2W15 A;  3AYK A;  2X3A A;  1CK7 A;  2OW9 A;  4I03 A;  4ZR5 A;  4GR0 A;  1WNI A;  1SRP A;  4PKQ A;  4IUW A;  2OI0 A;  4WF6 A;  5I3M A;  1MMQ A;  1HFC A;  4JIJ A;  2Y6C A;  3F19 A;  1GXD A;  1BZS A;  4PKR A;  5B5P A;  1IAG A;  4H82 A;  1OM8 A;  2MLR A;  3TSK A;  3I7G A;  3AYU A;  3CKI A;  3EDZ A;  1OS9 A;  4H3X A;  4I35 A;  1CIZ A;  1MMR A;  4XM6 A;  1I73 A;  2ERO A;  4XBH A;  4PKV A;  1AST A;  2POJ A;  1AYK A;  3B2Z A;  1R55 A;  3LIR A;  1JK3 A;  2E2D A;  1Y8J A;  1I76 A;  2W0D A;  2D1O A;  1RMZ A;  1PWQ A;  1O0Q A;  3VTG A;  4DPE A;  1K7G A;  1C8T A;  2MZH A;  1MNC A;  3EDI A;  2J83 A;  3B92 A;  5BPA A;  5I4O A;  1CGE A;  4Q1L A;  3K7L A;  1OM6 A;  2XS4 A;  2JT5 A;  3TVC A;  2D1N A;  1UTZ A;  1SAT A;  3KMC A;  2W13 A;  4DV8 A;  5JMY A;  4IJO A;  1UMS A;  1GKD A;  1OO9 A;  1BUD A;  2RJP A;  3ZUK A;  1BUV M;  2N8R A;  4H2E A;  3LUN A;  2O3E A;  3KHI A;  1Y93 A;  4WKE A;  1IAE A;  2OZR A;  1BQO A;  2OW2 A;  3EHX A;  1JAP A;  3K7N A;  3ZXH A;  1IAD A;  4GQL A;  1ZP5 A;  3F15 A;  1C7K A;  3O2X A;  1G05 A;  4WK7 A;  1JAN A;  4L63 A;  4WKI A;  1OM7 A;  3EHY A;  1XFZ A;  2Z2D A;  4EFS A;  2CKI A;  3OHO A;  1I1I P;  3HBV P;  1ZTQ A;  3HDB A;  1HY7 A;  5CZM A;  3Q2G A;  3HB2 P;  3WV1 A;  4PKS A;  1JAQ A;  1DTH A;  3U1R A;  3DSL A;  5D1U A;  4G9L A;  1KUK A;  3SHI A;  3F1A A;  4HX3 A;  2RJQ A;  2X3B A;  1QJJ A;  4JP4 A;  1R1I A;  3DWB A;  4R3V A;  1SMP A;  1Q3A A;  1KUG A;  5CUH A;  4GUY A;  2OXW A;  2MZE A;  1PWU A;  4AYK A;  3P24 A;  3I7I A;  3EDG A;  1BIW A;  4H49 A;  3LMC A;  4A3W A;  2CLT A;  1S4B P;  456C A;  1XFV A;  4J4M A;  4DF9 A;  1CGF A;  1Y0V A;  1C3I A;  1BKC I;  2ERP A;  1KUF A;  2FV9 A;  2OW0 A;  1OS2 A;  1H71 P;  4A7B A;  1IAC A;  1CQR A;  5L7F A;  1A85 A;  1GO8 P;  2V4B A;  4CTH A;  1AF0 A;  1KUI A;  1XUR A;  1JKY A;  1BQQ M;  4XCT A;  3G42 A;  1FBL A;  4FU4 A;  1KAP P;  1B8Y A;  1JIZ A;  1YP1 A;  2I47 A;  2WO8 A;  3ZVS A;  2X3C A;  3O64 A;  1XFX A;  4L6T A;  1BSW A;  3HBU P;  2DDF A;  5I0L A;  5L79 A;  1D7X A;  1L6J A;  4PKU A;  3N2U A;  3KWV C;  3LQ0 A;  2J0T A;  2JT6 A;  3ELM A;  4L19 A;  1SLN A;  1JJ9 A;  2WO9 A;  1UMT A;  2W14 A;  1HFS A;  1K7I A;  2W12 A;  2OVX A;  3LJZ A;  2OXU A;  3LEA A;  2OW1 A;  2DW1 A;  4GWN A;  3EDH A;  1KUH A;  3F16 A;  1USN A;  1YQY A;  4G0D A;  1JAO A;  3RTT A;  1PWV A;  3USN A;  4JPA A;  2K2G A;  3KME A;  3DNG A;  1ZXV A;  2TCL A;  966C A;  1SU3 A;  1QIB A;  1G49 A;  3VI1 A;  1GKC A;  2AYK A;  1CGL A;  3KEC A;  1FLS A;  1UTT A;  3GBO A;  5D7W A;  2YIG A;  4ILW D;  4GF1 A;  3EWJ A;  3B8Z A;  3L0V A;  1GE6 A;  1UEA A;  2DW0 A;  1FM1 A;  5BOT A;  1QIC A;  830C A;  4PKW A;  5D3C A;  4AXQ A;  1GE5 A;  3BA0 A;  3HY9 A;  1G4K A;  1QJI A;  3LIL A;  5I12 A;  2OVZ A;  4DD8 A;  1R1J A;  2JNP A;  1HTD A;  1R1H A;  4IN9 A;  1RM8 A;  4AUO A;  1Z3J A;  3LQB A;  4GR3 A;  1MMB A;  1G9K A;  2SRT A;  1YCM A;  2MLS A;  1MMP A;  3F18 A;  4GWM A;  4AIG A;  3RTS A;  4H1Q A;  3NX7 A;  1R54 A;  3KRY A;  1K7Q A;  4PKT A;  1XUD A;  2AIG P;  4WZV A;  1XUC A;  2X7M A;  1EB6 A;  4XM8 A;  3N2V A;  2A8H A;  2JIH A;  1ZXC A;  2XS3 A;  1O0T A;  4JQG A;  1D8F A;  2QPJ A;  4FXY P;  5B5O A;  1EUB A;  2YB9 A;  2JSD A;  3KEK A;  1CAQ A;  4HMA A;  3TT4 A;  3HY7 A;  1XFY A;  3LUM A;  2OXZ A;  4GR8 A;  1BKC A;  1HOV A;  3LK8 A;  1ND1 A;  2DDY A;  2O36 A;  3E8R A;  2E3X A;  3G5C A;  3L0T A;  5D1S A;  3Q2H A;  1XFU A;  1G12 A;  2ERQ A;  3LE9 A;  1ZS0 A;  1IAB A;  1ZVX A;  2DW2 A;  2FV5 A;  4ON1 A;  3LJG A;  4H76 A;  2HU6 A;  3UVC A;  5I43 A;  1XFW A;  1GE7 A;  1YOU A;  1B3D A;  3DL1 A;  4QKZ A;  2Y6D A;  3P1V A;  5D1T A;  5H8X A;  1A86 A;  3OHL A;  4JA1 A;  1QUA A;  3F17 A;  1BKC E;  1HV5 A;  3HDA P;  1QIA A;  1PWW A;  3KEJ A;  1DMT A;  2OY2 A;  1D8M A;  3LJT A;  1JIW P;  1IAA A;  5LAB A;  2PJT A;  3LIK A;  3DPF A;  4H84 A;  5BOY A;  3WV2 A; 
#chains in the Genus database with same CATH topology
 1SLM A;  4XM7 A;  3MA2 A;  5D2B A;  1BM6 A;  2L0R A;  1ATL A;  1OMJ A;  1AKL A;  5CXA A;  3HYG A;  1GO7 P;  2OY4 A;  3AIG A;  1CXV A;  3V96 B;  2USN A;  4FXQ A;  2MZI A;  3LGP A;  1KBC A;  4H30 A;  2KRJ A;  3DPE A;  3LKA A;  1EAK A;  3TS4 A;  4FVL A;  1JH1 A;  5I2Z A;  1PWP A;  1J7N A;  2K9C A;  1D5J A;  3WV3 A;  2WOA A;  1ROS A;  2W15 A;  2YUF A;  3AYK A;  2X3A A;  1CK7 A;  2OW9 A;  4I03 A;  4ZR5 A;  4GR0 A;  1WNI A;  1SRP A;  4PKQ A;  4IUW A;  2OI0 A;  4WF6 A;  5I3M A;  1MMQ A;  1HFC A;  4JIJ A;  2Y6C A;  3F19 A;  1GXD A;  1BZS A;  4PKR A;  5B5P A;  1IAG A;  4H82 A;  1OM8 A;  2MLR A;  3TSK A;  3I7G A;  3AYU A;  3CKI A;  3EDZ A;  1OS9 A;  4H3X A;  4I35 A;  1CIZ A;  1MMR A;  4XM6 A;  1I73 A;  2ERO A;  4XBH A;  4PKV A;  1AST A;  2POJ A;  1AYK A;  3B2Z A;  1R55 A;  3LIR A;  1JK3 A;  1XM5 A;  2E2D A;  1Y8J A;  1I76 A;  2W0D A;  2D1O A;  1RMZ A;  1PWQ A;  1O0Q A;  3VTG A;  4DPE A;  1K7G A;  1C8T A;  2MZH A;  1MNC A;  3EDI A;  2J83 A;  3B92 A;  5BPA A;  5I4O A;  1CGE A;  4Q1L A;  3K7L A;  1OM6 A;  2XS4 A;  2JT5 A;  3TVC A;  2D1N A;  1UTZ A;  1SAT A;  3KMC A;  2W13 A;  4DV8 A;  5JMY A;  4IJO A;  1UMS A;  1GKD A;  1OO9 A;  1BUD A;  2RJP A;  3ZUK A;  1BUV M;  2N8R A;  4H2E A;  3LUN A;  2O3E A;  3KHI A;  1Y93 A;  4WKE A;  1IAE A;  2OZR A;  1BQO A;  2OW2 A;  3EHX A;  1JAP A;  3K7N A;  3ZXH A;  1IAD A;  4GQL A;  1ZP5 A;  3F15 A;  1C7K A;  3DTE A;  3O2X A;  1G05 A;  4WK7 A;  1JAN A;  4L63 A;  4WKI A;  1OM7 A;  3EHY A;  1XFZ A;  2Z2D A;  4EFS A;  2CKI A;  3OHO A;  1I1I P;  3HBV P;  1ZTQ A;  3HDB A;  1HY7 A;  5CZM A;  3Q2G A;  3HB2 P;  3WV1 A;  4PKS A;  1JAQ A;  1DTH A;  3U1R A;  3DSL A;  5D1U A;  4G9L A;  1KUK A;  3SHI A;  3F1A A;  4HX3 A;  2RJQ A;  2X3B A;  1QJJ A;  4JP4 A;  1R1I A;  3DWB A;  4L7A A;  4R3V A;  1SMP A;  1Q3A A;  1KUG A;  5CUH A;  4GUY A;  2OXW A;  2MZE A;  1PWU A;  4AYK A;  3P24 A;  3I7I A;  3EDG A;  1BIW A;  4H49 A;  3LMC A;  4A3W A;  2CLT A;  1S4B P;  456C A;  1XFV A;  4J4M A;  4DF9 A;  1CGF A;  1Y0V A;  1C3I A;  1BKC I;  2ERP A;  1KUF A;  2FV9 A;  2OW0 A;  1OS2 A;  1H71 P;  4A7B A;  1IAC A;  1CQR A;  5L7F A;  1A85 A;  1GO8 P;  2V4B A;  4CTH A;  1AF0 A;  1KUI A;  1XUR A;  1JKY A;  1BQQ M;  4XCT A;  3G42 A;  1FBL A;  4FU4 A;  1KAP P;  1B8Y A;  1JIZ A;  1YP1 A;  2I47 A;  2WO8 A;  3DTK A;  3ZVS A;  2X3C A;  3O64 A;  1XFX A;  4L6T A;  1BSW A;  3HBU P;  2DDF A;  5I0L A;  5L79 A;  1D7X A;  1L6J A;  4PKU A;  3N2U A;  3KWV C;  3LQ0 A;  2J0T A;  2JT6 A;  3ELM A;  4L19 A;  1SLN A;  1JJ9 A;  2WO9 A;  1UMT A;  2W14 A;  1HFS A;  1K7I A;  2W12 A;  2OVX A;  3LJZ A;  2OXU A;  3LEA A;  2OW1 A;  2DW1 A;  4GWN A;  3EDH A;  1KUH A;  3F16 A;  1USN A;  1YQY A;  4G0D A;  1JAO A;  3RTT A;  1PWV A;  3USN A;  4JPA A;  2K2G A;  3KME A;  3DNG A;  1ZXV A;  2TCL A;  966C A;  1SU3 A;  1QIB A;  1G49 A;  3VI1 A;  1GKC A;  2AYK A;  1CGL A;  3KEC A;  1FLS A;  1UTT A;  3GBO A;  5D7W A;  2YIG A;  4ILW D;  4GF1 A;  3EWJ A;  3B8Z A;  3L0V A;  1GE6 A;  1UEA A;  2DW0 A;  1FM1 A;  5BOT A;  1QIC A;  830C A;  4PKW A;  5D3C A;  4AXQ A;  1GE5 A;  3BA0 A;  3HY9 A;  3DTI A;  1G4K A;  1QJI A;  3LIL A;  5I12 A;  2OVZ A;  4DD8 A;  1R1J A;  2JNP A;  1HTD A;  1R1H A;  4IN9 A;  1RM8 A;  4AUO A;  1Z3J A;  3LQB A;  4GR3 A;  1XAX A;  1MMB A;  1G9K A;  2SRT A;  1YCM A;  2MLS A;  1MMP A;  3F18 A;  4GWM A;  4AIG A;  3RTS A;  4H1Q A;  3NX7 A;  1R54 A;  3KRY A;  1K7Q A;  4PKT A;  1XUD A;  2AIG P;  4WZV A;  1XUC A;  2X7M A;  1EB6 A;  4XM8 A;  3N2V A;  2A8H A;  2JIH A;  1ZXC A;  2XS3 A;  1O0T A;  4JQG A;  1D8F A;  2QPJ A;  4FXY P;  5B5O A;  1EUB A;  2YB9 A;  2JSD A;  3KEK A;  1CAQ A;  4HMA A;  3TT4 A;  3HY7 A;  1XFY A;  3LUM A;  2OXZ A;  4GR8 A;  1BKC A;  1HOV A;  3LK8 A;  1ND1 A;  2DDY A;  1OZ9 A;  2O36 A;  3E8R A;  2E3X A;  3G5C A;  3L0T A;  5D1S A;  3Q2H A;  1XFU A;  1G12 A;  2ERQ A;  3LE9 A;  1ZS0 A;  1IAB A;  1ZVX A;  2DW2 A;  2FV5 A;  4ON1 A;  3LJG A;  4H76 A;  2HU6 A;  3UVC A;  5I43 A;  1XFW A;  1GE7 A;  1YOU A;  1B3D A;  3DL1 A;  4QKZ A;  2Y6D A;  3P1V A;  5D1T A;  5H8X A;  1A86 A;  3OHL A;  4JA1 A;  1QUA A;  3F17 A;  1BKC E;  1HV5 A;  3HDA P;  1QIA A;  1PWW A;  3KEJ A;  1TVI A;  1DMT A;  2OY2 A;  1D8M A;  3LJT A;  1JIW P;  1IAA A;  5LAB A;  2PJT A;  3LIK A;  3DPF A;  4H84 A;  5BOY A;  3WV2 A; 
#chains in the Genus database with same CATH homology
 1SLM A;  4XM7 A;  3MA2 A;  5D2B A;  1BM6 A;  2L0R A;  1ATL A;  1OMJ A;  1AKL A;  5CXA A;  3HYG A;  1GO7 P;  2OY4 A;  3AIG A;  1CXV A;  3V96 B;  2USN A;  4FXQ A;  2MZI A;  3LGP A;  1KBC A;  4H30 A;  2KRJ A;  3DPE A;  3LKA A;  1EAK A;  3TS4 A;  4FVL A;  1JH1 A;  5I2Z A;  1PWP A;  1J7N A;  2K9C A;  1D5J A;  3WV3 A;  2WOA A;  1ROS A;  2W15 A;  2YUF A;  3AYK A;  2X3A A;  1CK7 A;  2OW9 A;  4I03 A;  4ZR5 A;  4GR0 A;  1WNI A;  1SRP A;  4PKQ A;  4IUW A;  2OI0 A;  4WF6 A;  5I3M A;  1MMQ A;  1HFC A;  4JIJ A;  2Y6C A;  3F19 A;  1GXD A;  1BZS A;  4PKR A;  5B5P A;  1IAG A;  4H82 A;  1OM8 A;  2MLR A;  3TSK A;  3I7G A;  3AYU A;  3CKI A;  3EDZ A;  1OS9 A;  4H3X A;  4I35 A;  1CIZ A;  1MMR A;  4XM6 A;  1I73 A;  2ERO A;  4XBH A;  4PKV A;  1AST A;  2POJ A;  1AYK A;  3B2Z A;  1R55 A;  3LIR A;  1JK3 A;  2E2D A;  1Y8J A;  1I76 A;  2W0D A;  2D1O A;  1RMZ A;  1PWQ A;  1O0Q A;  3VTG A;  4DPE A;  1K7G A;  1C8T A;  2MZH A;  1MNC A;  3EDI A;  2J83 A;  3B92 A;  5BPA A;  5I4O A;  1CGE A;  4Q1L A;  3K7L A;  1OM6 A;  2XS4 A;  2JT5 A;  3TVC A;  2D1N A;  1UTZ A;  1SAT A;  3KMC A;  2W13 A;  4DV8 A;  5JMY A;  4IJO A;  1UMS A;  1GKD A;  1OO9 A;  1BUD A;  2RJP A;  3ZUK A;  1BUV M;  2N8R A;  4H2E A;  3LUN A;  2O3E A;  3KHI A;  1Y93 A;  4WKE A;  1IAE A;  2OZR A;  1BQO A;  2OW2 A;  3EHX A;  1JAP A;  3K7N A;  3ZXH A;  1IAD A;  4GQL A;  1ZP5 A;  3F15 A;  1C7K A;  3DTE A;  3O2X A;  1G05 A;  4WK7 A;  1JAN A;  4L63 A;  4WKI A;  1OM7 A;  3EHY A;  1XFZ A;  2Z2D A;  4EFS A;  2CKI A;  3OHO A;  1I1I P;  3HBV P;  1ZTQ A;  3HDB A;  1HY7 A;  5CZM A;  3Q2G A;  3HB2 P;  3WV1 A;  4PKS A;  1JAQ A;  1DTH A;  3U1R A;  3DSL A;  5D1U A;  4G9L A;  1KUK A;  3SHI A;  3F1A A;  4HX3 A;  2RJQ A;  2X3B A;  1QJJ A;  4JP4 A;  1R1I A;  3DWB A;  4L7A A;  4R3V A;  1SMP A;  1Q3A A;  1KUG A;  5CUH A;  4GUY A;  2OXW A;  2MZE A;  1PWU A;  4AYK A;  3P24 A;  3I7I A;  3EDG A;  1BIW A;  4H49 A;  3LMC A;  4A3W A;  2CLT A;  1S4B P;  456C A;  1XFV A;  4J4M A;  4DF9 A;  1CGF A;  1Y0V A;  1C3I A;  1BKC I;  2ERP A;  1KUF A;  2FV9 A;  2OW0 A;  1OS2 A;  1H71 P;  4A7B A;  1IAC A;  1CQR A;  5L7F A;  1A85 A;  1GO8 P;  2V4B A;  4CTH A;  1AF0 A;  1KUI A;  1XUR A;  1JKY A;  1BQQ M;  4XCT A;  3G42 A;  1FBL A;  4FU4 A;  1KAP P;  1B8Y A;  1JIZ A;  1YP1 A;  2I47 A;  2WO8 A;  3DTK A;  3ZVS A;  2X3C A;  3O64 A;  1XFX A;  4L6T A;  1BSW A;  3HBU P;  2DDF A;  5I0L A;  5L79 A;  1D7X A;  1L6J A;  4PKU A;  3N2U A;  3KWV C;  3LQ0 A;  2J0T A;  2JT6 A;  3ELM A;  4L19 A;  1SLN A;  1JJ9 A;  2WO9 A;  1UMT A;  2W14 A;  1HFS A;  1K7I A;  2W12 A;  2OVX A;  3LJZ A;  2OXU A;  3LEA A;  2OW1 A;  2DW1 A;  4GWN A;  3EDH A;  1KUH A;  3F16 A;  1USN A;  1YQY A;  4G0D A;  1JAO A;  3RTT A;  1PWV A;  3USN A;  4JPA A;  2K2G A;  3KME A;  3DNG A;  1ZXV A;  2TCL A;  966C A;  1SU3 A;  1QIB A;  1G49 A;  3VI1 A;  1GKC A;  2AYK A;  1CGL A;  3KEC A;  1FLS A;  1UTT A;  3GBO A;  5D7W A;  2YIG A;  4ILW D;  4GF1 A;  3EWJ A;  3B8Z A;  3L0V A;  1GE6 A;  1UEA A;  2DW0 A;  1FM1 A;  5BOT A;  1QIC A;  830C A;  4PKW A;  5D3C A;  4AXQ A;  1GE5 A;  3BA0 A;  3HY9 A;  3DTI A;  1G4K A;  1QJI A;  3LIL A;  5I12 A;  2OVZ A;  4DD8 A;  1R1J A;  2JNP A;  1HTD A;  1R1H A;  4IN9 A;  1RM8 A;  4AUO A;  1Z3J A;  3LQB A;  4GR3 A;  1MMB A;  1G9K A;  2SRT A;  1YCM A;  2MLS A;  1MMP A;  3F18 A;  4GWM A;  4AIG A;  3RTS A;  4H1Q A;  3NX7 A;  1R54 A;  3KRY A;  1K7Q A;  4PKT A;  1XUD A;  2AIG P;  4WZV A;  1XUC A;  2X7M A;  1EB6 A;  4XM8 A;  3N2V A;  2A8H A;  2JIH A;  1ZXC A;  2XS3 A;  1O0T A;  4JQG A;  1D8F A;  2QPJ A;  4FXY P;  5B5O A;  1EUB A;  2YB9 A;  2JSD A;  3KEK A;  1CAQ A;  4HMA A;  3TT4 A;  3HY7 A;  1XFY A;  3LUM A;  2OXZ A;  4GR8 A;  1BKC A;  1HOV A;  3LK8 A;  1ND1 A;  2DDY A;  2O36 A;  3E8R A;  2E3X A;  3G5C A;  3L0T A;  5D1S A;  3Q2H A;  1XFU A;  1G12 A;  2ERQ A;  3LE9 A;  1ZS0 A;  1IAB A;  1ZVX A;  2DW2 A;  2FV5 A;  4ON1 A;  3LJG A;  4H76 A;  2HU6 A;  3UVC A;  5I43 A;  1XFW A;  1GE7 A;  1YOU A;  1B3D A;  3DL1 A;  4QKZ A;  2Y6D A;  3P1V A;  5D1T A;  5H8X A;  1A86 A;  3OHL A;  4JA1 A;  1QUA A;  3F17 A;  1BKC E;  1HV5 A;  3HDA P;  1QIA A;  1PWW A;  3KEJ A;  1DMT A;  2OY2 A;  1D8M A;  3LJT A;  1JIW P;  1IAA A;  5LAB A;  2PJT A;  3LIK A;  3DPF A;  4H84 A;  5BOY A;  3WV2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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