3HYGA

Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
217
structure length
217
Chain Sequence
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 73
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2009-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3hygA00
3I7GA 4AXQA 3HBUP 3LKAA 1XURA 3TS4A 3KWVC 4GWMA 4JPAA 4J4MA 1BQOA 4XM8A 3HDBA 3K7NA 5I0LA 4CTHA 2O36A 4WKIA 4PKRA 3RTSA 3HDAP 2POJA 1MMRA 3GBOA 1OO9A 1FLSA 1I1IP 5I2ZA 3F15A 3LIKA 2X3CA 4XM6A 2X3BA 3KMEA 1MNCA 4A3WA 1Y93A 2KRJA 1Q3AA 4JIJA 2W13A 1D7XA 2O3EA 2MLSA 3LILA 1DMTA 1IAAA 3KRYA 1IAGA 2XS3A 1PWPA 3WV3A 4HMAA 4PKSA 3DNGA 1OM8A 4G0DA 1K7GA 3K7LA 1K7IA 4PKVA 1RMZA 3KECA 4ILWD 1IADA 1SU3A 1WNIA 3EDGA 1D8FA 4PKTA 4H76A 3OHOA 1C8TA 4PKQA 2WO9A 4GQLA 2OY4A 4DPEA 1FM1A 5BOTA 2AIGP 1ZTQA 3EHYA 2TCLA 1QIBA 1D8MA 3DSLA 4PKWA 3V96B 2W0DA 3DWBA 4AIGA 4H82A 4ZR5A 1I76A 5CZMA 966CA 4AYKA 1XFZA 2OW2A 3VI1A 1QUAA 3CKIA 1HV5A 1BSWA 4H3XA 1EB6A 4DD8A 2MZIA 1HFSA 3NX7A 2OI0A 3ELMA 1GE7A 5LABA 1KUKA 3DPEA 1GO7P 3DL1A 2X3AA 1IAEA 4R3VA 1BKCE 1GO8P 1XUCA 3P1VA 4FXYP 456CA 1MMQA 1XFWA 3TVCA 5I12A 2JSDA 3G42A 4H30A 4QKZA 2OXZA 1XFXA 3EDZA 2CLTA 5L7FA 5BOYA 1GE5A 4L6TA 3LJZA 4XM7A 1ZXVA 1BUDA 2W14A 5D1SA 4H1QA 5D7WA 5D1TA 5I3MA 1JKYA 1IABA 1A85A 3SHIA 2JT5A 2DW1A 3ZXHA 2RJQA 1JIZA 2J83A 5BPAA 4DV8A 1CAQA 1YQYA 2OW9A 3F16A 3RTTA 830CA 5I43A 4L63A 3LJTA 4EFSA 1R54A 3KHIA 4L19A 3LK8A 2DDYA 2E3XA 2OXUA 2MZHA 3AYUA 1CIZA 3AIGA 3EWJA 1USNA 1GXDA 1SATA 2HU6A 1HFCA 5D1UA 1JH1A 1R55A 2PJTA 1G05A 3LEAA 1B8YA 1HY7A 1EUBA 1G9KA 2MLRA 2D1OA 1BM6A 5JMYA 4JQGA 1C7KA 1GKCA 4GR3A 1YCMA 1CGEA 3EDHA 1CXVA 1R1HA 3F18A 5D3CA 2OY2A 1XFVA 1ZVXA 2FV5A 1JANA 2N8RA 1OS9A 1PWWA 4HX3A 1HTDA 5H8XA 1CQRA 1UMSA 3F17A 2V4BA 1I73A 1KAPP 1DTHA 3WV2A 2OW0A 3HBVP 3HY9A 3B2ZA 1SRPA 1SMPA 1XFUA 4JP4A 3ZVSA 2RJPA 3L0TA 4H2EA 1KUHA 1CK7A 4WK7A 4IN9A 1OS2A 2YB9A 2DW2A 1XFYA 1AKLA 5D2BA 2OVXA 1ROSA 4DF9A 1XUDA 1J7NA 2A8HA 4H49A 4WZVA 1JAQA 2USNA 4IJOA 5CUHA 1JAPA 2EROA 1ASTA 1YP1A 3USNA 3B8ZA 2QPJA 2K2GA 3Q2HA 2Y6CA 3I7IA 3OHLA 5I4OA 4FU4A 1PWQA 2ERPA 4AUOA 1Y8JA 3LGPA 4GWNA 3TSKA 2YIGA 3DPFA 4IUWA 1UTTA 2JT6A 2OXWA 3HB2P 3KMCA 4PKUA 2DDFA 1JK3A 1UMTA 1G4KA 4G9LA 1SLNA 4ON1A 1AYKA 4GF1A 4H84A 3LQ0A 1O0TA 1OMJA 2Y6DA 4I35A 1G49A 4WF6A 1A86A 1Z3JA 3G5CA 1KUGA 3ZUKA 1ZS0A 3HYGA 2X7MA 5B5OA 1BQQM 3EHXA 3LMCA 4FVLA 2SRTA 1PWVA 1QICA 3BA0A 3HY7A 1Y0VA 4XBHA 1MMBA 2W12A 2JNPA 3LQBA 1UTZA 1QIAA 3LUNA 1D5JA 3Q2GA 1ZXCA 3F1AA 1FBLA 2ERQA 1BIWA 2WOAA 3P24A 1B3DA 1GKDA 1KUIA 3L0VA 1KBCA 3AYKA 1BKCI 3O2XA 3KEKA 2OVZA 4GUYA 4A7BA 3LE9A 1ND1A 2I47A 4GR8A 4I03A 3WV1A 1UEAA 2D1NA 3KEJA 2J0TA 1BUVM 1GE6A 1QJIA 5CXAA 1ATLA 1JIWP 1R1IA 1QJJA 3O64A 2K9CA 1G12A 4Q1LA 4JA1A 1CGLA 2JIHA 1EAKA 2E2DA 3EDIA 4GR0A 4WKEA 3N2VA 1AF0A 1PWUA 4XCTA 2OW1A 1BZSA 1SLMA 4FXQA 2AYKA 2DW0A 2XS4A 1BKCA 1L6JA 1ZP5A 3VTGA 1HOVA 3N2UA 3F19A 1JAOA 1S4BP 2WO8A 1RM8A 2CKIA 2W15A 2L0RA 2Z2DA 3LIRA 3LUMA 3E8RA 1CGFA 3UVCA 1H71P 1K7QA 2OZRA 3MA2A 3B92A 1R1JA 1OM7A 3U1RA 1MMPA 3LJGA 1O0QA 5B5PA 2MZEA 1KUFA 2FV9A 3TT4A 1JJ9A 5L79A 1YOUA 1C3IA 1IACA 1OM6A
chains in the Genus database with same CATH superfamily
3I7GA 4AXQA 3HBUP 3LKAA 1XURA 3TS4A 3KWVC 4GWMA 4JPAA 4J4MA 1BQOA 4XM8A 3HDBA 3K7NA 5I0LA 4CTHA 2O36A 4WKIA 4PKRA 3RTSA 3HDAP 2POJA 1MMRA 3GBOA 1OO9A 1FLSA 1I1IP 5I2ZA 3F15A 3LIKA 2X3CA 4XM6A 2X3BA 3KMEA 1MNCA 4A3WA 1Y93A 2KRJA 1Q3AA 4JIJA 2W13A 1D7XA 2O3EA 2MLSA 3LILA 1DMTA 1IAAA 3KRYA 1IAGA 2XS3A 1PWPA 3WV3A 4HMAA 4PKSA 3DNGA 1OM8A 4G0DA 1K7GA 3K7LA 1K7IA 4PKVA 1RMZA 3KECA 4ILWD 1IADA 1SU3A 1WNIA 3EDGA 1D8FA 4PKTA 4H76A 3OHOA 1C8TA 4PKQA 2WO9A 4GQLA 2OY4A 4DPEA 1FM1A 5BOTA 2AIGP 1ZTQA 3EHYA 2TCLA 1QIBA 1D8MA 3DSLA 3DTIA 4PKWA 3V96B 2W0DA 3DWBA 4AIGA 4H82A 4ZR5A 1I76A 5CZMA 966CA 4AYKA 1XFZA 2OW2A 3VI1A 1QUAA 3CKIA 1HV5A 1BSWA 4H3XA 1EB6A 4DD8A 2MZIA 1HFSA 3NX7A 2OI0A 3ELMA 1GE7A 5LABA 1KUKA 3DPEA 1GO7P 3DL1A 2YUFA 2X3AA 1IAEA 4R3VA 1BKCE 1GO8P 1XUCA 3P1VA 4FXYP 456CA 1MMQA 1XFWA 3TVCA 5I12A 2JSDA 3G42A 4H30A 4QKZA 2OXZA 1XFXA 3EDZA 2CLTA 5L7FA 5BOYA 1GE5A 4L6TA 3LJZA 4XM7A 1ZXVA 1BUDA 2W14A 5D1SA 4H1QA 5D7WA 5D1TA 5I3MA 1JKYA 1IABA 1A85A 3SHIA 2JT5A 2DW1A 3ZXHA 2RJQA 1JIZA 2J83A 5BPAA 4DV8A 1CAQA 1YQYA 2OW9A 3F16A 3RTTA 830CA 5I43A 4L63A 3LJTA 4EFSA 1R54A 3KHIA 4L19A 3LK8A 2DDYA 2E3XA 2OXUA 2MZHA 3AYUA 1CIZA 3AIGA 3EWJA 1USNA 1GXDA 1SATA 2HU6A 1HFCA 5D1UA 1JH1A 1R55A 1OZ9A 2PJTA 1G05A 3LEAA 1B8YA 1HY7A 1EUBA 1G9KA 2MLRA 2D1OA 1BM6A 5JMYA 4JQGA 1C7KA 1GKCA 4GR3A 1YCMA 1CGEA 3EDHA 1CXVA 1R1HA 3F18A 5D3CA 2OY2A 1XFVA 1XAXA 1ZVXA 2FV5A 1JANA 2N8RA 1OS9A 1PWWA 4HX3A 1HTDA 3DTKA 5H8XA 1CQRA 1UMSA 3F17A 2V4BA 1I73A 1KAPP 1DTHA 3WV2A 2OW0A 3HBVP 3HY9A 3B2ZA 1SRPA 1SMPA 1XFUA 4JP4A 4L7AA 2RJPA 3ZVSA 3L0TA 4H2EA 1KUHA 1CK7A 4WK7A 4IN9A 1OS2A 2YB9A 2DW2A 1XFYA 1AKLA 5D2BA 2OVXA 1ROSA 4DF9A 1XUDA 1J7NA 2A8HA 4H49A 4WZVA 1JAQA 2USNA 4IJOA 5CUHA 1JAPA 2EROA 1ASTA 1YP1A 3USNA 3B8ZA 2QPJA 2K2GA 3Q2HA 2Y6CA 3I7IA 3OHLA 5I4OA 4FU4A 1PWQA 2ERPA 4AUOA 1Y8JA 3LGPA 4GWNA 3TSKA 2YIGA 3DPFA 4IUWA 1UTTA 2JT6A 2OXWA 3HB2P 3KMCA 4PKUA 2DDFA 1JK3A 1UMTA 1G4KA 4G9LA 1SLNA 4ON1A 1AYKA 4GF1A 4H84A 3LQ0A 1O0TA 1OMJA 2Y6DA 4I35A 1G49A 4WF6A 1A86A 1Z3JA 3G5CA 1KUGA 3ZUKA 1ZS0A 3HYGA 2X7MA 5B5OA 1BQQM 3EHXA 3DTEA 3LMCA 4FVLA 2SRTA 1PWVA 1QICA 3BA0A 3HY7A 1Y0VA 4XBHA 1MMBA 2W12A 2JNPA 3LQBA 1UTZA 1QIAA 3LUNA 1TVIA 1D5JA 3Q2GA 1ZXCA 3F1AA 1FBLA 2ERQA 1BIWA 2WOAA 3P24A 1B3DA 1GKDA 1KUIA 3L0VA 1KBCA 3AYKA 1BKCI 3O2XA 3KEKA 2OVZA 4GUYA 4A7BA 3LE9A 1ND1A 2I47A 4GR8A 4I03A 3WV1A 1UEAA 2D1NA 3KEJA 2J0TA 1BUVM 1GE6A 1QJIA 5CXAA 1ATLA 1JIWP 1R1IA 1QJJA 3O64A 1XM5A 2K9CA 1G12A 4Q1LA 4JA1A 1CGLA 2JIHA 1EAKA 2E2DA 3EDIA 4GR0A 4WKEA 3N2VA 1AF0A 1PWUA 4XCTA 2OW1A 1BZSA 1SLMA 4FXQA 2AYKA 2DW0A 2XS4A 1BKCA 1L6JA 1ZP5A 3VTGA 1HOVA 3N2UA 3F19A 1JAOA 1S4BP 2WO8A 1RM8A 2CKIA 2W15A 2L0RA 2Z2DA 3LIRA 3LUMA 3E8RA 1CGFA 3UVCA 1H71P 1K7QA 2OZRA 3MA2A 3B92A 1R1JA 1OM7A 3U1RA 1MMPA 3LJGA 1O0QA 5B5PA 2MZEA 1KUFA 2FV9A 3TT4A 1JJ9A 5L79A 1YOUA 1C3IA 1IACA 1OM6A
chains in the Genus database with same CATH topology
3I7GA 4AXQA 3HBUP 3LKAA 1XURA 3TS4A 3KWVC 4GWMA 4JPAA 4J4MA 1BQOA 4XM8A 3HDBA 3K7NA 5I0LA 4CTHA 2O36A 4WKIA 4PKRA 3RTSA 3HDAP 2POJA 1MMRA 3GBOA 1OO9A 1FLSA 1I1IP 5I2ZA 3F15A 3LIKA 2X3CA 4XM6A 2X3BA 3KMEA 1MNCA 4A3WA 1Y93A 2KRJA 1Q3AA 4JIJA 2W13A 1D7XA 2O3EA 2MLSA 3LILA 1DMTA 1IAAA 3KRYA 1IAGA 2XS3A 1PWPA 3WV3A 4HMAA 4PKSA 3DNGA 1OM8A 4G0DA 1K7GA 3K7LA 1K7IA 4PKVA 1RMZA 3KECA 4ILWD 1IADA 1SU3A 1WNIA 3EDGA 1D8FA 4PKTA 4H76A 3OHOA 1C8TA 4PKQA 2WO9A 4GQLA 2OY4A 4DPEA 1FM1A 5BOTA 2AIGP 1ZTQA 3EHYA 2TCLA 1QIBA 1D8MA 3DSLA 3DTIA 4PKWA 3V96B 2W0DA 3DWBA 4AIGA 4H82A 4ZR5A 1I76A 5CZMA 966CA 4AYKA 1XFZA 2OW2A 3VI1A 1QUAA 3CKIA 1HV5A 1BSWA 4H3XA 1EB6A 4DD8A 2MZIA 1HFSA 3NX7A 2OI0A 3ELMA 1GE7A 5LABA 1KUKA 3DPEA 1GO7P 3DL1A 2YUFA 2X3AA 1IAEA 4R3VA 1BKCE 1GO8P 1XUCA 3P1VA 4FXYP 456CA 1MMQA 1XFWA 3TVCA 5I12A 2JSDA 3G42A 4H30A 4QKZA 2OXZA 1XFXA 3EDZA 2CLTA 5L7FA 5BOYA 1GE5A 4L6TA 3LJZA 4XM7A 1ZXVA 1BUDA 2W14A 5D1SA 4H1QA 5D7WA 5D1TA 5I3MA 1JKYA 1IABA 1A85A 3SHIA 2JT5A 2DW1A 3ZXHA 2RJQA 1JIZA 2J83A 5BPAA 4DV8A 1CAQA 1YQYA 2OW9A 3F16A 3RTTA 830CA 5I43A 4L63A 3LJTA 4EFSA 1R54A 3KHIA 4L19A 3LK8A 2DDYA 2E3XA 2OXUA 2MZHA 3AYUA 1CIZA 3AIGA 3EWJA 1USNA 1GXDA 1SATA 2HU6A 1HFCA 5D1UA 1JH1A 1R55A 2PJTA 1G05A 3LEAA 1B8YA 1HY7A 1EUBA 1G9KA 2MLRA 2D1OA 1BM6A 5JMYA 4JQGA 1C7KA 1GKCA 4GR3A 1YCMA 1CGEA 3EDHA 1CXVA 1R1HA 3F18A 5D3CA 2OY2A 1XFVA 1ZVXA 2FV5A 1JANA 2N8RA 1OS9A 1PWWA 4HX3A 1HTDA 3DTKA 5H8XA 1CQRA 1UMSA 3F17A 2V4BA 1I73A 1KAPP 1DTHA 3WV2A 2OW0A 3HBVP 3HY9A 3B2ZA 1SRPA 1SMPA 1XFUA 4JP4A 4L7AA 2RJPA 3ZVSA 3L0TA 4H2EA 1KUHA 1CK7A 4WK7A 4IN9A 1OS2A 2YB9A 2DW2A 1XFYA 1AKLA 5D2BA 2OVXA 1ROSA 4DF9A 1XUDA 1J7NA 2A8HA 4H49A 4WZVA 1JAQA 2USNA 4IJOA 5CUHA 1JAPA 2EROA 1ASTA 1YP1A 3USNA 3B8ZA 2QPJA 2K2GA 3Q2HA 2Y6CA 3I7IA 3OHLA 5I4OA 4FU4A 1PWQA 2ERPA 4AUOA 1Y8JA 3LGPA 4GWNA 3TSKA 2YIGA 3DPFA 4IUWA 1UTTA 2JT6A 2OXWA 3HB2P 3KMCA 4PKUA 2DDFA 1JK3A 1UMTA 1G4KA 4G9LA 1SLNA 4ON1A 1AYKA 4GF1A 4H84A 3LQ0A 1O0TA 1OMJA 2Y6DA 4I35A 1G49A 4WF6A 1A86A 1Z3JA 3G5CA 1KUGA 3ZUKA 1ZS0A 3HYGA 2X7MA 5B5OA 1BQQM 3EHXA 3DTEA 3LMCA 4FVLA 2SRTA 1PWVA 1QICA 3BA0A 3HY7A 1Y0VA 4XBHA 1MMBA 2W12A 2JNPA 3LQBA 1UTZA 1QIAA 3LUNA 1D5JA 3Q2GA 1ZXCA 3F1AA 1FBLA 2ERQA 1BIWA 2WOAA 3P24A 1B3DA 1GKDA 1KUIA 3L0VA 1KBCA 3AYKA 1BKCI 3O2XA 3KEKA 2OVZA 4GUYA 4A7BA 3LE9A 1ND1A 2I47A 4GR8A 4I03A 3WV1A 1UEAA 2D1NA 3KEJA 2J0TA 1BUVM 1GE6A 1QJIA 5CXAA 1ATLA 1JIWP 1R1IA 1QJJA 3O64A 2K9CA 1G12A 4Q1LA 4JA1A 1CGLA 2JIHA 1EAKA 2E2DA 3EDIA 4GR0A 4WKEA 3N2VA 1AF0A 1PWUA 4XCTA 2OW1A 1BZSA 1SLMA 4FXQA 2AYKA 2DW0A 2XS4A 1BKCA 1L6JA 1ZP5A 3VTGA 1HOVA 3N2UA 3F19A 1JAOA 1S4BP 2WO8A 1RM8A 2CKIA 2W15A 2L0RA 2Z2DA 3LIRA 3LUMA 3E8RA 1CGFA 3UVCA 1H71P 1K7QA 2OZRA 3MA2A 3B92A 1R1JA 1OM7A 3U1RA 1MMPA 3LJGA 1O0QA 5B5PA 2MZEA 1KUFA 2FV9A 3TT4A 1JJ9A 5L79A 1YOUA 1C3IA 1IACA 1OM6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I7G A;  4AXQ A;  3HBU P;  3LKA A;  1XUR A;  3TS4 A;  3KWV C;  4GWM A;  4JPA A;  4J4M A;  1BQO A;  4XM8 A;  3HDB A;  3K7N A;  5I0L A;  4CTH A;  2O36 A;  4WKI A;  4PKR A;  3RTS A;  3HDA P;  2POJ A;  1MMR A;  3GBO A;  1OO9 A;  1FLS A;  1I1I P;  5I2Z A;  3F15 A;  3LIK A;  2X3C A;  4XM6 A;  2X3B A;  3KME A;  1MNC A;  4A3W A;  1Y93 A;  2KRJ A;  1Q3A A;  4JIJ A;  2W13 A;  1D7X A;  2O3E A;  2MLS A;  3LIL A;  1DMT A;  1IAA A;  3KRY A;  1IAG A;  2XS3 A;  1PWP A;  3WV3 A;  4HMA A;  4PKS A;  3DNG A;  1OM8 A;  4G0D A;  1K7G A;  3K7L A;  1K7I A;  4PKV A;  1RMZ A;  3KEC A;  4ILW D;  1IAD A;  1SU3 A;  1WNI A;  3EDG A;  1D8F A;  4PKT A;  4H76 A;  3OHO A;  1C8T A;  4PKQ A;  2WO9 A;  4GQL A;  2OY4 A;  4DPE A;  1FM1 A;  5BOT A;  2AIG P;  1ZTQ A;  3EHY A;  2TCL A;  1QIB A;  1D8M A;  3DSL A;  4PKW A;  3V96 B;  2W0D A;  3DWB A;  4AIG A;  4H82 A;  4ZR5 A;  1I76 A;  5CZM A;  966C A;  4AYK A;  1XFZ A;  2OW2 A;  3VI1 A;  1QUA A;  3CKI A;  1HV5 A;  1BSW A;  4H3X A;  1EB6 A;  4DD8 A;  2MZI A;  1HFS A;  3NX7 A;  2OI0 A;  3ELM A;  1GE7 A;  5LAB A;  1KUK A;  3DPE A;  1GO7 P;  3DL1 A;  2X3A A;  1IAE A;  4R3V A;  1BKC E;  1GO8 P;  1XUC A;  3P1V A;  4FXY P;  456C A;  1MMQ A;  1XFW A;  3TVC A;  5I12 A;  2JSD A;  3G42 A;  4H30 A;  4QKZ A;  2OXZ A;  1XFX A;  3EDZ A;  2CLT A;  5L7F A;  5BOY A;  1GE5 A;  4L6T A;  3LJZ A;  4XM7 A;  1ZXV A;  1BUD A;  2W14 A;  5D1S A;  4H1Q A;  5D7W A;  5D1T A;  5I3M A;  1JKY A;  1IAB A;  1A85 A;  3SHI A;  2JT5 A;  2DW1 A;  3ZXH A;  2RJQ A;  1JIZ A;  2J83 A;  5BPA A;  4DV8 A;  1CAQ A;  1YQY A;  2OW9 A;  3F16 A;  3RTT A;  830C A;  5I43 A;  4L63 A;  3LJT A;  4EFS A;  1R54 A;  3KHI A;  4L19 A;  3LK8 A;  2DDY A;  2E3X A;  2OXU A;  2MZH A;  3AYU A;  1CIZ A;  3AIG A;  3EWJ A;  1USN A;  1GXD A;  1SAT A;  2HU6 A;  1HFC A;  5D1U A;  1JH1 A;  1R55 A;  2PJT A;  1G05 A;  3LEA A;  1B8Y A;  1HY7 A;  1EUB A;  1G9K A;  2MLR A;  2D1O A;  1BM6 A;  5JMY A;  4JQG A;  1C7K A;  1GKC A;  4GR3 A;  1YCM A;  1CGE A;  3EDH A;  1CXV A;  1R1H A;  3F18 A;  5D3C A;  2OY2 A;  1XFV A;  1ZVX A;  2FV5 A;  1JAN A;  2N8R A;  1OS9 A;  1PWW A;  4HX3 A;  1HTD A;  5H8X A;  1CQR A;  1UMS A;  3F17 A;  2V4B A;  1I73 A;  1KAP P;  1DTH A;  3WV2 A;  2OW0 A;  3HBV P;  3HY9 A;  3B2Z A;  1SRP A;  1SMP A;  1XFU A;  4JP4 A;  3ZVS A;  2RJP A;  3L0T A;  4H2E A;  1KUH A;  1CK7 A;  4WK7 A;  4IN9 A;  1OS2 A;  2YB9 A;  2DW2 A;  1XFY A;  1AKL A;  5D2B A;  2OVX A;  1ROS A;  4DF9 A;  1XUD A;  1J7N A;  2A8H A;  4H49 A;  4WZV A;  1JAQ A;  2USN A;  4IJO A;  5CUH A;  1JAP A;  2ERO A;  1AST A;  1YP1 A;  3USN A;  3B8Z A;  2QPJ A;  2K2G A;  3Q2H A;  2Y6C A;  3I7I A;  3OHL A;  5I4O A;  4FU4 A;  1PWQ A;  2ERP A;  4AUO A;  1Y8J A;  3LGP A;  4GWN A;  3TSK A;  2YIG A;  3DPF A;  4IUW A;  1UTT A;  2JT6 A;  2OXW A;  3HB2 P;  3KMC A;  4PKU A;  2DDF A;  1JK3 A;  1UMT A;  1G4K A;  4G9L A;  1SLN A;  4ON1 A;  1AYK A;  4GF1 A;  4H84 A;  3LQ0 A;  1O0T A;  1OMJ A;  2Y6D A;  4I35 A;  1G49 A;  4WF6 A;  1A86 A;  1Z3J A;  3G5C A;  1KUG A;  3ZUK A;  1ZS0 A;  3HYG A;  2X7M A;  5B5O A;  1BQQ M;  3EHX A;  3LMC A;  4FVL A;  2SRT A;  1PWV A;  1QIC A;  3BA0 A;  3HY7 A;  1Y0V A;  4XBH A;  1MMB A;  2W12 A;  2JNP A;  3LQB A;  1UTZ A;  1QIA A;  3LUN A;  1D5J A;  3Q2G A;  1ZXC A;  3F1A A;  1FBL A;  2ERQ A;  1BIW A;  2WOA A;  3P24 A;  1B3D A;  1GKD A;  1KUI A;  3L0V A;  1KBC A;  3AYK A;  1BKC I;  3O2X A;  3KEK A;  2OVZ A;  4GUY A;  4A7B A;  3LE9 A;  1ND1 A;  2I47 A;  4GR8 A;  4I03 A;  3WV1 A;  1UEA A;  2D1N A;  3KEJ A;  2J0T A;  1BUV M;  1GE6 A;  1QJI A;  5CXA A;  1ATL A;  1JIW P;  1R1I A;  1QJJ A;  3O64 A;  2K9C A;  1G12 A;  4Q1L A;  4JA1 A;  1CGL A;  2JIH A;  1EAK A;  2E2D A;  3EDI A;  4GR0 A;  4WKE A;  3N2V A;  1AF0 A;  1PWU A;  4XCT A;  2OW1 A;  1BZS A;  1SLM A;  4FXQ A;  2AYK A;  2DW0 A;  2XS4 A;  1BKC A;  1L6J A;  1ZP5 A;  3VTG A;  1HOV A;  3N2U A;  3F19 A;  1JAO A;  1S4B P;  2WO8 A;  1RM8 A;  2CKI A;  2W15 A;  2L0R A;  2Z2D A;  3LIR A;  3LUM A;  3E8R A;  1CGF A;  3UVC A;  1H71 P;  1K7Q A;  2OZR A;  3MA2 A;  3B92 A;  1R1J A;  1OM7 A;  3U1R A;  1MMP A;  3LJG A;  1O0Q A;  5B5P A;  2MZE A;  1KUF A;  2FV9 A;  3TT4 A;  1JJ9 A;  5L79 A;  1YOU A;  1C3I A;  1IAC A;  1OM6 A; 
#chains in the Genus database with same CATH topology
 3I7G A;  4AXQ A;  3HBU P;  3LKA A;  1XUR A;  3TS4 A;  3KWV C;  4GWM A;  4JPA A;  4J4M A;  1BQO A;  4XM8 A;  3HDB A;  3K7N A;  5I0L A;  4CTH A;  2O36 A;  4WKI A;  4PKR A;  3RTS A;  3HDA P;  2POJ A;  1MMR A;  3GBO A;  1OO9 A;  1FLS A;  1I1I P;  5I2Z A;  3F15 A;  3LIK A;  2X3C A;  4XM6 A;  2X3B A;  3KME A;  1MNC A;  4A3W A;  1Y93 A;  2KRJ A;  1Q3A A;  4JIJ A;  2W13 A;  1D7X A;  2O3E A;  2MLS A;  3LIL A;  1DMT A;  1IAA A;  3KRY A;  1IAG A;  2XS3 A;  1PWP A;  3WV3 A;  4HMA A;  4PKS A;  3DNG A;  1OM8 A;  4G0D A;  1K7G A;  3K7L A;  1K7I A;  4PKV A;  1RMZ A;  3KEC A;  4ILW D;  1IAD A;  1SU3 A;  1WNI A;  3EDG A;  1D8F A;  4PKT A;  4H76 A;  3OHO A;  1C8T A;  4PKQ A;  2WO9 A;  4GQL A;  2OY4 A;  4DPE A;  1FM1 A;  5BOT A;  2AIG P;  1ZTQ A;  3EHY A;  2TCL A;  1QIB A;  1D8M A;  3DSL A;  3DTI A;  4PKW A;  3V96 B;  2W0D A;  3DWB A;  4AIG A;  4H82 A;  4ZR5 A;  1I76 A;  5CZM A;  966C A;  4AYK A;  1XFZ A;  2OW2 A;  3VI1 A;  1QUA A;  3CKI A;  1HV5 A;  1BSW A;  4H3X A;  1EB6 A;  4DD8 A;  2MZI A;  1HFS A;  3NX7 A;  2OI0 A;  3ELM A;  1GE7 A;  5LAB A;  1KUK A;  3DPE A;  1GO7 P;  3DL1 A;  2YUF A;  2X3A A;  1IAE A;  4R3V A;  1BKC E;  1GO8 P;  1XUC A;  3P1V A;  4FXY P;  456C A;  1MMQ A;  1XFW A;  3TVC A;  5I12 A;  2JSD A;  3G42 A;  4H30 A;  4QKZ A;  2OXZ A;  1XFX A;  3EDZ A;  2CLT A;  5L7F A;  5BOY A;  1GE5 A;  4L6T A;  3LJZ A;  4XM7 A;  1ZXV A;  1BUD A;  2W14 A;  5D1S A;  4H1Q A;  5D7W A;  5D1T A;  5I3M A;  1JKY A;  1IAB A;  1A85 A;  3SHI A;  2JT5 A;  2DW1 A;  3ZXH A;  2RJQ A;  1JIZ A;  2J83 A;  5BPA A;  4DV8 A;  1CAQ A;  1YQY A;  2OW9 A;  3F16 A;  3RTT A;  830C A;  5I43 A;  4L63 A;  3LJT A;  4EFS A;  1R54 A;  3KHI A;  4L19 A;  3LK8 A;  2DDY A;  2E3X A;  2OXU A;  2MZH A;  3AYU A;  1CIZ A;  3AIG A;  3EWJ A;  1USN A;  1GXD A;  1SAT A;  2HU6 A;  1HFC A;  5D1U A;  1JH1 A;  1R55 A;  1OZ9 A;  2PJT A;  1G05 A;  3LEA A;  1B8Y A;  1HY7 A;  1EUB A;  1G9K A;  2MLR A;  2D1O A;  1BM6 A;  5JMY A;  4JQG A;  1C7K A;  1GKC A;  4GR3 A;  1YCM A;  1CGE A;  3EDH A;  1CXV A;  1R1H A;  3F18 A;  5D3C A;  2OY2 A;  1XFV A;  1XAX A;  1ZVX A;  2FV5 A;  1JAN A;  2N8R A;  1OS9 A;  1PWW A;  4HX3 A;  1HTD A;  3DTK A;  5H8X A;  1CQR A;  1UMS A;  3F17 A;  2V4B A;  1I73 A;  1KAP P;  1DTH A;  3WV2 A;  2OW0 A;  3HBV P;  3HY9 A;  3B2Z A;  1SRP A;  1SMP A;  1XFU A;  4JP4 A;  4L7A A;  2RJP A;  3ZVS A;  3L0T A;  4H2E A;  1KUH A;  1CK7 A;  4WK7 A;  4IN9 A;  1OS2 A;  2YB9 A;  2DW2 A;  1XFY A;  1AKL A;  5D2B A;  2OVX A;  1ROS A;  4DF9 A;  1XUD A;  1J7N A;  2A8H A;  4H49 A;  4WZV A;  1JAQ A;  2USN A;  4IJO A;  5CUH A;  1JAP A;  2ERO A;  1AST A;  1YP1 A;  3USN A;  3B8Z A;  2QPJ A;  2K2G A;  3Q2H A;  2Y6C A;  3I7I A;  3OHL A;  5I4O A;  4FU4 A;  1PWQ A;  2ERP A;  4AUO A;  1Y8J A;  3LGP A;  4GWN A;  3TSK A;  2YIG A;  3DPF A;  4IUW A;  1UTT A;  2JT6 A;  2OXW A;  3HB2 P;  3KMC A;  4PKU A;  2DDF A;  1JK3 A;  1UMT A;  1G4K A;  4G9L A;  1SLN A;  4ON1 A;  1AYK A;  4GF1 A;  4H84 A;  3LQ0 A;  1O0T A;  1OMJ A;  2Y6D A;  4I35 A;  1G49 A;  4WF6 A;  1A86 A;  1Z3J A;  3G5C A;  1KUG A;  3ZUK A;  1ZS0 A;  3HYG A;  2X7M A;  5B5O A;  1BQQ M;  3EHX A;  3DTE A;  3LMC A;  4FVL A;  2SRT A;  1PWV A;  1QIC A;  3BA0 A;  3HY7 A;  1Y0V A;  4XBH A;  1MMB A;  2W12 A;  2JNP A;  3LQB A;  1UTZ A;  1QIA A;  3LUN A;  1TVI A;  1D5J A;  3Q2G A;  1ZXC A;  3F1A A;  1FBL A;  2ERQ A;  1BIW A;  2WOA A;  3P24 A;  1B3D A;  1GKD A;  1KUI A;  3L0V A;  1KBC A;  3AYK A;  1BKC I;  3O2X A;  3KEK A;  2OVZ A;  4GUY A;  4A7B A;  3LE9 A;  1ND1 A;  2I47 A;  4GR8 A;  4I03 A;  3WV1 A;  1UEA A;  2D1N A;  3KEJ A;  2J0T A;  1BUV M;  1GE6 A;  1QJI A;  5CXA A;  1ATL A;  1JIW P;  1R1I A;  1QJJ A;  3O64 A;  1XM5 A;  2K9C A;  1G12 A;  4Q1L A;  4JA1 A;  1CGL A;  2JIH A;  1EAK A;  2E2D A;  3EDI A;  4GR0 A;  4WKE A;  3N2V A;  1AF0 A;  1PWU A;  4XCT A;  2OW1 A;  1BZS A;  1SLM A;  4FXQ A;  2AYK A;  2DW0 A;  2XS4 A;  1BKC A;  1L6J A;  1ZP5 A;  3VTG A;  1HOV A;  3N2U A;  3F19 A;  1JAO A;  1S4B P;  2WO8 A;  1RM8 A;  2CKI A;  2W15 A;  2L0R A;  2Z2D A;  3LIR A;  3LUM A;  3E8R A;  1CGF A;  3UVC A;  1H71 P;  1K7Q A;  2OZR A;  3MA2 A;  3B92 A;  1R1J A;  1OM7 A;  3U1R A;  1MMP A;  3LJG A;  1O0Q A;  5B5P A;  2MZE A;  1KUF A;  2FV9 A;  3TT4 A;  1JJ9 A;  5L79 A;  1YOU A;  1C3I A;  1IAC A;  1OM6 A; 
#chains in the Genus database with same CATH homology
 3I7G A;  4AXQ A;  3HBU P;  3LKA A;  1XUR A;  3TS4 A;  3KWV C;  4GWM A;  4JPA A;  4J4M A;  1BQO A;  4XM8 A;  3HDB A;  3K7N A;  5I0L A;  4CTH A;  2O36 A;  4WKI A;  4PKR A;  3RTS A;  3HDA P;  2POJ A;  1MMR A;  3GBO A;  1OO9 A;  1FLS A;  1I1I P;  5I2Z A;  3F15 A;  3LIK A;  2X3C A;  4XM6 A;  2X3B A;  3KME A;  1MNC A;  4A3W A;  1Y93 A;  2KRJ A;  1Q3A A;  4JIJ A;  2W13 A;  1D7X A;  2O3E A;  2MLS A;  3LIL A;  1DMT A;  1IAA A;  3KRY A;  1IAG A;  2XS3 A;  1PWP A;  3WV3 A;  4HMA A;  4PKS A;  3DNG A;  1OM8 A;  4G0D A;  1K7G A;  3K7L A;  1K7I A;  4PKV A;  1RMZ A;  3KEC A;  4ILW D;  1IAD A;  1SU3 A;  1WNI A;  3EDG A;  1D8F A;  4PKT A;  4H76 A;  3OHO A;  1C8T A;  4PKQ A;  2WO9 A;  4GQL A;  2OY4 A;  4DPE A;  1FM1 A;  5BOT A;  2AIG P;  1ZTQ A;  3EHY A;  2TCL A;  1QIB A;  1D8M A;  3DSL A;  3DTI A;  4PKW A;  3V96 B;  2W0D A;  3DWB A;  4AIG A;  4H82 A;  4ZR5 A;  1I76 A;  5CZM A;  966C A;  4AYK A;  1XFZ A;  2OW2 A;  3VI1 A;  1QUA A;  3CKI A;  1HV5 A;  1BSW A;  4H3X A;  1EB6 A;  4DD8 A;  2MZI A;  1HFS A;  3NX7 A;  2OI0 A;  3ELM A;  1GE7 A;  5LAB A;  1KUK A;  3DPE A;  1GO7 P;  3DL1 A;  2YUF A;  2X3A A;  1IAE A;  4R3V A;  1BKC E;  1GO8 P;  1XUC A;  3P1V A;  4FXY P;  456C A;  1MMQ A;  1XFW A;  3TVC A;  5I12 A;  2JSD A;  3G42 A;  4H30 A;  4QKZ A;  2OXZ A;  1XFX A;  3EDZ A;  2CLT A;  5L7F A;  5BOY A;  1GE5 A;  4L6T A;  3LJZ A;  4XM7 A;  1ZXV A;  1BUD A;  2W14 A;  5D1S A;  4H1Q A;  5D7W A;  5D1T A;  5I3M A;  1JKY A;  1IAB A;  1A85 A;  3SHI A;  2JT5 A;  2DW1 A;  3ZXH A;  2RJQ A;  1JIZ A;  2J83 A;  5BPA A;  4DV8 A;  1CAQ A;  1YQY A;  2OW9 A;  3F16 A;  3RTT A;  830C A;  5I43 A;  4L63 A;  3LJT A;  4EFS A;  1R54 A;  3KHI A;  4L19 A;  3LK8 A;  2DDY A;  2E3X A;  2OXU A;  2MZH A;  3AYU A;  1CIZ A;  3AIG A;  3EWJ A;  1USN A;  1GXD A;  1SAT A;  2HU6 A;  1HFC A;  5D1U A;  1JH1 A;  1R55 A;  2PJT A;  1G05 A;  3LEA A;  1B8Y A;  1HY7 A;  1EUB A;  1G9K A;  2MLR A;  2D1O A;  1BM6 A;  5JMY A;  4JQG A;  1C7K A;  1GKC A;  4GR3 A;  1YCM A;  1CGE A;  3EDH A;  1CXV A;  1R1H A;  3F18 A;  5D3C A;  2OY2 A;  1XFV A;  1ZVX A;  2FV5 A;  1JAN A;  2N8R A;  1OS9 A;  1PWW A;  4HX3 A;  1HTD A;  3DTK A;  5H8X A;  1CQR A;  1UMS A;  3F17 A;  2V4B A;  1I73 A;  1KAP P;  1DTH A;  3WV2 A;  2OW0 A;  3HBV P;  3HY9 A;  3B2Z A;  1SRP A;  1SMP A;  1XFU A;  4JP4 A;  4L7A A;  2RJP A;  3ZVS A;  3L0T A;  4H2E A;  1KUH A;  1CK7 A;  4WK7 A;  4IN9 A;  1OS2 A;  2YB9 A;  2DW2 A;  1XFY A;  1AKL A;  5D2B A;  2OVX A;  1ROS A;  4DF9 A;  1XUD A;  1J7N A;  2A8H A;  4H49 A;  4WZV A;  1JAQ A;  2USN A;  4IJO A;  5CUH A;  1JAP A;  2ERO A;  1AST A;  1YP1 A;  3USN A;  3B8Z A;  2QPJ A;  2K2G A;  3Q2H A;  2Y6C A;  3I7I A;  3OHL A;  5I4O A;  4FU4 A;  1PWQ A;  2ERP A;  4AUO A;  1Y8J A;  3LGP A;  4GWN A;  3TSK A;  2YIG A;  3DPF A;  4IUW A;  1UTT A;  2JT6 A;  2OXW A;  3HB2 P;  3KMC A;  4PKU A;  2DDF A;  1JK3 A;  1UMT A;  1G4K A;  4G9L A;  1SLN A;  4ON1 A;  1AYK A;  4GF1 A;  4H84 A;  3LQ0 A;  1O0T A;  1OMJ A;  2Y6D A;  4I35 A;  1G49 A;  4WF6 A;  1A86 A;  1Z3J A;  3G5C A;  1KUG A;  3ZUK A;  1ZS0 A;  3HYG A;  2X7M A;  5B5O A;  1BQQ M;  3EHX A;  3DTE A;  3LMC A;  4FVL A;  2SRT A;  1PWV A;  1QIC A;  3BA0 A;  3HY7 A;  1Y0V A;  4XBH A;  1MMB A;  2W12 A;  2JNP A;  3LQB A;  1UTZ A;  1QIA A;  3LUN A;  1D5J A;  3Q2G A;  1ZXC A;  3F1A A;  1FBL A;  2ERQ A;  1BIW A;  2WOA A;  3P24 A;  1B3D A;  1GKD A;  1KUI A;  3L0V A;  1KBC A;  3AYK A;  1BKC I;  3O2X A;  3KEK A;  2OVZ A;  4GUY A;  4A7B A;  3LE9 A;  1ND1 A;  2I47 A;  4GR8 A;  4I03 A;  3WV1 A;  1UEA A;  2D1N A;  3KEJ A;  2J0T A;  1BUV M;  1GE6 A;  1QJI A;  5CXA A;  1ATL A;  1JIW P;  1R1I A;  1QJJ A;  3O64 A;  2K9C A;  1G12 A;  4Q1L A;  4JA1 A;  1CGL A;  2JIH A;  1EAK A;  2E2D A;  3EDI A;  4GR0 A;  4WKE A;  3N2V A;  1AF0 A;  1PWU A;  4XCT A;  2OW1 A;  1BZS A;  1SLM A;  4FXQ A;  2AYK A;  2DW0 A;  2XS4 A;  1BKC A;  1L6J A;  1ZP5 A;  3VTG A;  1HOV A;  3N2U A;  3F19 A;  1JAO A;  1S4B P;  2WO8 A;  1RM8 A;  2CKI A;  2W15 A;  2L0R A;  2Z2D A;  3LIR A;  3LUM A;  3E8R A;  1CGF A;  3UVC A;  1H71 P;  1K7Q A;  2OZR A;  3MA2 A;  3B92 A;  1R1J A;  1OM7 A;  3U1R A;  1MMP A;  3LJG A;  1O0Q A;  5B5P A;  2MZE A;  1KUF A;  2FV9 A;  3TT4 A;  1JJ9 A;  5L79 A;  1YOU A;  1C3I A;  1IAC A;  1OM6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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