3HYGA

Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
217
structure length
217
Chain Sequence
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
pubmed doi rcsb
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 73
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2009-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3hygA00
2W12A 3LMCA 1ND1A 4XM8A 1XUDA 3L0TA 4L19A 2JSDA 3LQ0A 4L63A 1IACA 1OS2A 3ELMA 5D1SA 1C3IA 1ROSA 4GUYA 1KUHA 1FLSA 2PJTA 3EDIA 830CA 1BQQM 1BUDA 4JPAA 2DDYA 1BUVM 1YP1A 5BOYA 3O2XA 1CGFA 2AIGP 2MLRA 4QKZA 3E8RA 1SRPA 3AYUA 4I35A 2OXZA 5L7FA 2E3XA 3KMEA 2DDFA 4GR3A 1AKLA 2OW9A 1MMBA 4XBHA 3RTSA 1HFCA 3B2ZA 3ZXHA 1WNIA 2QPJA 4FU4A 4ON1A 1ZXCA 1ZVXA 4H84A 1JAOA 4FVLA 1RMZA 1SU3A 1BKCI 2OXUA 1H71P 1GKCA 2OZRA 1CXVA 1YCMA 1BM6A 4G9LA 3DWBA 3N2VA 4IN9A 5CUHA 2JT5A 4GWMA 3KRYA 3RTTA 5I43A 1QJIA 1DMTA 5D7WA 3HBUP 4GWNA 1B8YA 3WV2A 1D8MA 2MZIA 3LK8A 1A85A 3F15A 4G0DA 1O0QA 4HMAA 1RM8A 2X3AA 1QIBA 1CK7A 3G5CA 1QICA 2JT6A 4WF6A 1A86A 4HX3A 3HY9A 4PKSA 4WK7A 2YIGA 1XFZA 3AYKA 1QIAA 1BKCA 4PKQA 1HFSA 2FV5A 4WZVA 1I76A 4AIGA 1Z3JA 3OHOA 5CZMA 1K7QA 2DW2A 1ZTQA 2WO9A 2E2DA 1PWUA 4R3VA 4GF1A 5D3CA 2OXWA 1JIWP 1BZSA 1D5JA 1AYKA 2TCLA 3WV1A 1KBCA 2X3CA 4L6TA 1UEAA 1HTDA 2D1OA 5I12A 1BQOA 2JIHA 1JIZA 1IABA 3DNGA 3LIKA 4GQLA 1KAPP 2RJPA 2WO8A 1UTZA 1KUKA 1SATA 4FXYP 5JMYA 2OI0A 1G9KA 3F1AA 3DPEA 1QUAA 2Z2DA 4PKWA 3EDGA 2O3EA 1KUFA 3WV3A 1XUCA 3GBOA 1UMTA 3LILA 3F16A 1XFYA 1XFVA 2OVZA 4A7BA 3VTGA 4IUWA 1R1HA 3TSKA 1HV5A 1S4BP 4AUOA 5D1TA 1Y93A 1CIZA 1I1IP 1ZP5A 3KMCA 1ZS0A 2ERQA 1GKDA 4XM7A 1SLMA 2SRTA 1PWPA 1OO9A 3OHLA 2RJQA 2POJA 5I4OA 1UTTA 4PKTA 2X7MA 3U1RA 3DSLA 2HU6A 1D8FA 1Y8JA 1Y0VA 1JAQA 1K7GA 1SLNA 5I3MA 3B8ZA 1XFUA 5D1UA 4XM6A 2JNPA 3K7LA 5B5OA 2V4BA 1AF0A 1XFWA 2W0DA 3DL1A 3KEJA 3USNA 5BOTA 2CKIA 1ATLA 2WOAA 4XCTA 3LEAA 5LABA 4JIJA 3LQBA 3NX7A 2MZHA 3F19A 1GXDA 4A3WA 2W14A 1GE7A 3VI1A 3LGPA 1OM6A 3HDBA 1B3DA 2ERPA 1KUIA 3CKIA 2J83A 1SMPA 1MMPA 4H30A 1G4KA 1G12A 2K2GA 2OW1A 3B92A 4H2EA 3UVCA 4DF9A 1GE5A 1CGLA 1UMSA 1R54A 3KECA 4JP4A 3MA2A 4CTHA 4I03A 4AXQA 1L6JA 1JAPA 5H8XA 3L0VA 1HY7A 1FM1A 1CGEA 2FV9A 4GR8A 4H3XA 5I0LA 3K7NA 3HB2P 3EDZA 3LJGA 3TVCA 1OMJA 3ZVSA 456CA 2CLTA 2DW1A 3LUMA 4DPEA 1IAEA 2L0RA 3N2UA 3G42A 1O0TA 2W13A 2MLSA 2Y6CA 4PKUA 4WKEA 4FXQA 1IAAA 4IJOA 5I2ZA 4PKVA 1CAQA 3Q2HA 3LUNA 3BA0A 4EFSA 1YOUA 3EHXA 3TT4A 4Q1LA 3HDAP 5BPAA 3KEKA 3LJZA 4ILWD 5D2BA 2I47A 3I7IA 1IAGA 1MMQA 4H82A 1MNCA 1XURA 1G49A 1JKYA 2USNA 3F18A 2Y6DA 1I73A 3AIGA 3KHIA 966CA 1QJJA 4H49A 2AYKA 2J0TA 3KWVC 4H1QA 2KRJA 2X3BA 3I7GA 1C8TA 1ZXVA 4AYKA 3Q2GA 3EWJA 1J7NA 2OY2A 3HY7A 4GR0A 2N8RA 1EB6A 1PWQA 2OW2A 4DV8A 3F17A 3P24A 1G05A 1R1JA 2D1NA 3ZUKA 1ASTA 3SHIA 5L79A 1R1IA 1YQYA 1EAKA 3HYGA 1BSWA 1JJ9A 1BIWA 1OM7A 4JA1A 2YB9A 2A8HA 4J4MA 2DW0A 2OW0A 2OY4A 5B5PA 2MZEA 1PWWA 4H76A 2XS3A 1K7IA 1PWVA 1BKCE 4WKIA 3V96B 2W15A 1FBLA 1GO7P 1JANA 3O64A 3LE9A 1Q3AA 2EROA 2XS4A 1IADA 1CQRA 3EHYA 3HBVP 1MMRA 1HOVA 1GO8P 4ZR5A 4DD8A 5CXAA 2OVXA 3LIRA 1D7XA 1C7KA 1DTHA 2O36A 1OM8A 3TS4A 2K9CA 1OS9A 3EDHA 4PKRA 1GE6A 1USNA 3LKAA 3DPFA 4JQGA 1KUGA 1JK3A 3P1VA 1JH1A 1EUBA 3LJTA 1R55A 1XFXA
chains in the Genus database with same CATH superfamily
2W12A 3LMCA 1ND1A 4XM8A 1XUDA 3L0TA 4L19A 2JSDA 3LQ0A 4L63A 1IACA 1OS2A 3ELMA 5D1SA 1C3IA 1ROSA 4GUYA 1KUHA 1FLSA 2PJTA 3EDIA 830CA 1BQQM 1BUDA 4JPAA 2DDYA 1BUVM 1YP1A 5BOYA 3O2XA 1CGFA 2AIGP 2MLRA 4QKZA 3E8RA 1SRPA 3AYUA 4I35A 2OXZA 5L7FA 2E3XA 3KMEA 3DTKA 2DDFA 4GR3A 1AKLA 2OW9A 1MMBA 4XBHA 3RTSA 1HFCA 3B2ZA 3ZXHA 1WNIA 2QPJA 4FU4A 4ON1A 1ZXCA 1ZVXA 4H84A 1JAOA 4FVLA 1RMZA 1SU3A 1BKCI 2OXUA 1H71P 1GKCA 2OZRA 1CXVA 1YCMA 1BM6A 4G9LA 3DWBA 3N2VA 4IN9A 5CUHA 2JT5A 4GWMA 3KRYA 3RTTA 5I43A 1QJIA 1DMTA 5D7WA 3HBUP 4GWNA 1B8YA 3WV2A 1D8MA 2MZIA 3LK8A 1A85A 3F15A 4G0DA 1O0QA 4HMAA 1RM8A 2X3AA 1QIBA 1CK7A 3G5CA 1QICA 2JT6A 4WF6A 1A86A 4HX3A 1XAXA 3HY9A 4PKSA 4WK7A 2YIGA 1XFZA 3AYKA 1QIAA 1BKCA 4PKQA 1HFSA 2FV5A 4WZVA 1I76A 4AIGA 1Z3JA 3OHOA 5CZMA 1K7QA 2DW2A 1ZTQA 2WO9A 2E2DA 1PWUA 4R3VA 4GF1A 5D3CA 2OXWA 1JIWP 1BZSA 1D5JA 1AYKA 2TCLA 3WV1A 1KBCA 2X3CA 4L6TA 1UEAA 1HTDA 2D1OA 5I12A 1BQOA 2JIHA 1JIZA 1IABA 3DNGA 3LIKA 4GQLA 1KAPP 2RJPA 2WO8A 1UTZA 1KUKA 1SATA 4FXYP 5JMYA 2OI0A 1G9KA 3F1AA 3DPEA 1QUAA 2Z2DA 4PKWA 3EDGA 2O3EA 1KUFA 3WV3A 1XUCA 3GBOA 1UMTA 3LILA 3F16A 1XFYA 1XFVA 2OVZA 4A7BA 3VTGA 4IUWA 1R1HA 3TSKA 1HV5A 1S4BP 4AUOA 5D1TA 1Y93A 1CIZA 1I1IP 1ZP5A 3KMCA 1ZS0A 2ERQA 1GKDA 4XM7A 3DTIA 1SLMA 2SRTA 1PWPA 1OO9A 3OHLA 2RJQA 2POJA 5I4OA 1UTTA 4PKTA 2X7MA 3U1RA 3DSLA 2HU6A 1D8FA 1Y8JA 1Y0VA 1JAQA 1K7GA 1SLNA 5I3MA 3B8ZA 1XFUA 5D1UA 4XM6A 2JNPA 3K7LA 5B5OA 2V4BA 1AF0A 1XFWA 2W0DA 3DL1A 3KEJA 3USNA 5BOTA 2CKIA 1ATLA 2WOAA 4XCTA 3LEAA 5LABA 4JIJA 3LQBA 3NX7A 2MZHA 3F19A 1GXDA 4A3WA 2W14A 1GE7A 3VI1A 3LGPA 1OM6A 3HDBA 1OZ9A 1B3DA 2ERPA 1KUIA 3CKIA 2J83A 1SMPA 1MMPA 4H30A 1G4KA 1G12A 2K2GA 2OW1A 3B92A 4H2EA 3UVCA 4DF9A 1GE5A 1CGLA 1UMSA 1R54A 3KECA 4JP4A 3MA2A 4CTHA 4I03A 4AXQA 1L6JA 1JAPA 5H8XA 3L0VA 1HY7A 1FM1A 1CGEA 1XM5A 2FV9A 4GR8A 4H3XA 5I0LA 3K7NA 3HB2P 3EDZA 3LJGA 3TVCA 1OMJA 3DTEA 3ZVSA 456CA 2CLTA 2DW1A 3LUMA 4DPEA 1IAEA 2L0RA 3N2UA 3G42A 1O0TA 2W13A 2MLSA 2Y6CA 4PKUA 4WKEA 4FXQA 1IAAA 4IJOA 5I2ZA 4PKVA 1CAQA 3Q2HA 3LUNA 3BA0A 4EFSA 1YOUA 3EHXA 3TT4A 4Q1LA 3HDAP 5BPAA 3KEKA 3LJZA 4ILWD 5D2BA 2I47A 3I7IA 1IAGA 1MMQA 4H82A 1MNCA 1XURA 1G49A 1JKYA 2USNA 3F18A 2Y6DA 1I73A 3AIGA 3KHIA 966CA 1QJJA 4H49A 2AYKA 2J0TA 3KWVC 4H1QA 2KRJA 2X3BA 3I7GA 1C8TA 1ZXVA 4AYKA 3Q2GA 3EWJA 1J7NA 2OY2A 3HY7A 4GR0A 2N8RA 1EB6A 1PWQA 2OW2A 4DV8A 2YUFA 3F17A 3P24A 1G05A 1R1JA 2D1NA 3ZUKA 1ASTA 3SHIA 5L79A 1TVIA 1R1IA 1YQYA 1EAKA 3HYGA 1BSWA 1JJ9A 1BIWA 1OM7A 4JA1A 2YB9A 2A8HA 4J4MA 2DW0A 2OW0A 2OY4A 5B5PA 2MZEA 1PWWA 4H76A 2XS3A 1K7IA 1PWVA 4L7AA 1BKCE 4WKIA 3V96B 2W15A 1FBLA 1GO7P 1JANA 3O64A 3LE9A 1Q3AA 2EROA 2XS4A 1IADA 1CQRA 3EHYA 3HBVP 1MMRA 1HOVA 1GO8P 4ZR5A 4DD8A 5CXAA 2OVXA 3LIRA 1D7XA 1C7KA 1DTHA 2O36A 1OM8A 3TS4A 2K9CA 1OS9A 3EDHA 4PKRA 1GE6A 1USNA 3LKAA 3DPFA 4JQGA 1KUGA 1JK3A 3P1VA 1JH1A 1EUBA 3LJTA 1R55A 1XFXA
chains in the Genus database with same CATH topology
2W12A 3LMCA 1ND1A 4XM8A 1XUDA 3L0TA 4L19A 2JSDA 3LQ0A 4L63A 1IACA 1OS2A 3ELMA 5D1SA 1C3IA 1ROSA 4GUYA 1KUHA 1FLSA 2PJTA 3EDIA 830CA 1BQQM 1BUDA 4JPAA 2DDYA 1BUVM 1YP1A 5BOYA 3O2XA 1CGFA 2AIGP 2MLRA 4QKZA 3E8RA 1SRPA 3AYUA 4I35A 2OXZA 5L7FA 2E3XA 3KMEA 3DTKA 2DDFA 4GR3A 1AKLA 2OW9A 1MMBA 4XBHA 3RTSA 1HFCA 3B2ZA 3ZXHA 1WNIA 2QPJA 4FU4A 4ON1A 1ZXCA 1ZVXA 4H84A 1JAOA 4FVLA 1RMZA 1SU3A 1BKCI 2OXUA 1H71P 1GKCA 2OZRA 1CXVA 1YCMA 1BM6A 4G9LA 3DWBA 3N2VA 4IN9A 5CUHA 2JT5A 4GWMA 3KRYA 3RTTA 5I43A 1QJIA 1DMTA 5D7WA 3HBUP 4GWNA 1B8YA 3WV2A 1D8MA 2MZIA 3LK8A 1A85A 3F15A 4G0DA 1O0QA 4HMAA 1RM8A 2X3AA 1QIBA 1CK7A 3G5CA 1QICA 2JT6A 4WF6A 1A86A 4HX3A 3HY9A 4PKSA 4WK7A 2YIGA 1XFZA 3AYKA 1QIAA 1BKCA 4PKQA 1HFSA 2FV5A 4WZVA 1I76A 4AIGA 1Z3JA 3OHOA 5CZMA 1K7QA 2DW2A 1ZTQA 2WO9A 2E2DA 1PWUA 4R3VA 4GF1A 5D3CA 2OXWA 1JIWP 1BZSA 1D5JA 1AYKA 2TCLA 3WV1A 1KBCA 2X3CA 4L6TA 1UEAA 1HTDA 2D1OA 5I12A 1BQOA 2JIHA 1JIZA 1IABA 3DNGA 3LIKA 4GQLA 1KAPP 2RJPA 2WO8A 1UTZA 1KUKA 1SATA 4FXYP 5JMYA 2OI0A 1G9KA 3F1AA 3DPEA 1QUAA 2Z2DA 4PKWA 3EDGA 2O3EA 1KUFA 3WV3A 1XUCA 3GBOA 1UMTA 3LILA 3F16A 1XFYA 1XFVA 2OVZA 4A7BA 3VTGA 4IUWA 1R1HA 3TSKA 1HV5A 1S4BP 4AUOA 5D1TA 1Y93A 1CIZA 1I1IP 1ZP5A 3KMCA 1ZS0A 2ERQA 1GKDA 4XM7A 3DTIA 1SLMA 2SRTA 1PWPA 1OO9A 3OHLA 2RJQA 2POJA 5I4OA 1UTTA 4PKTA 2X7MA 3U1RA 3DSLA 2HU6A 1D8FA 1Y8JA 1Y0VA 1JAQA 1K7GA 1SLNA 5I3MA 3B8ZA 1XFUA 5D1UA 4XM6A 2JNPA 3K7LA 5B5OA 2V4BA 1AF0A 1XFWA 2W0DA 3DL1A 3KEJA 3USNA 5BOTA 2CKIA 1ATLA 2WOAA 4XCTA 3LEAA 5LABA 4JIJA 3LQBA 3NX7A 2MZHA 3F19A 1GXDA 4A3WA 2W14A 1GE7A 3VI1A 3LGPA 1OM6A 3HDBA 1B3DA 2ERPA 1KUIA 3CKIA 2J83A 1SMPA 1MMPA 4H30A 1G4KA 1G12A 2K2GA 2OW1A 3B92A 4H2EA 3UVCA 4DF9A 1GE5A 1CGLA 1UMSA 1R54A 3KECA 4JP4A 3MA2A 4CTHA 4I03A 4AXQA 1L6JA 1JAPA 5H8XA 3L0VA 1HY7A 1FM1A 1CGEA 2FV9A 4GR8A 4H3XA 5I0LA 3K7NA 3HB2P 3EDZA 3LJGA 3TVCA 1OMJA 3DTEA 3ZVSA 456CA 2CLTA 2DW1A 3LUMA 4DPEA 1IAEA 2L0RA 3N2UA 3G42A 1O0TA 2W13A 2MLSA 2Y6CA 4PKUA 4WKEA 4FXQA 1IAAA 4IJOA 5I2ZA 4PKVA 1CAQA 3Q2HA 3LUNA 3BA0A 4EFSA 1YOUA 3EHXA 3TT4A 4Q1LA 3HDAP 5BPAA 3KEKA 3LJZA 4ILWD 5D2BA 2I47A 3I7IA 1IAGA 1MMQA 4H82A 1MNCA 1XURA 1G49A 1JKYA 2USNA 3F18A 2Y6DA 1I73A 3AIGA 3KHIA 966CA 1QJJA 4H49A 2AYKA 2J0TA 3KWVC 4H1QA 2KRJA 2X3BA 3I7GA 1C8TA 1ZXVA 4AYKA 3Q2GA 3EWJA 1J7NA 2OY2A 3HY7A 4GR0A 2N8RA 1EB6A 1PWQA 2OW2A 4DV8A 2YUFA 3F17A 3P24A 1G05A 1R1JA 2D1NA 3ZUKA 1ASTA 3SHIA 5L79A 1R1IA 1YQYA 1EAKA 3HYGA 1BSWA 1JJ9A 1BIWA 1OM7A 4JA1A 2YB9A 2A8HA 4J4MA 2DW0A 2OW0A 2OY4A 5B5PA 2MZEA 1PWWA 4H76A 2XS3A 1K7IA 1PWVA 4L7AA 1BKCE 4WKIA 3V96B 2W15A 1FBLA 1GO7P 1JANA 3O64A 3LE9A 1Q3AA 2EROA 2XS4A 1IADA 1CQRA 3EHYA 3HBVP 1MMRA 1HOVA 1GO8P 4ZR5A 4DD8A 5CXAA 2OVXA 3LIRA 1D7XA 1C7KA 1DTHA 2O36A 1OM8A 3TS4A 2K9CA 1OS9A 3EDHA 4PKRA 1GE6A 1USNA 3LKAA 3DPFA 4JQGA 1KUGA 1JK3A 3P1VA 1JH1A 1EUBA 3LJTA 1R55A 1XFXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W12 A;  3LMC A;  1ND1 A;  4XM8 A;  1XUD A;  3L0T A;  4L19 A;  2JSD A;  3LQ0 A;  4L63 A;  1IAC A;  1OS2 A;  3ELM A;  5D1S A;  1C3I A;  1ROS A;  4GUY A;  1KUH A;  1FLS A;  2PJT A;  3EDI A;  830C A;  1BQQ M;  1BUD A;  4JPA A;  2DDY A;  1BUV M;  1YP1 A;  5BOY A;  3O2X A;  1CGF A;  2AIG P;  2MLR A;  4QKZ A;  3E8R A;  1SRP A;  3AYU A;  4I35 A;  2OXZ A;  5L7F A;  2E3X A;  3KME A;  2DDF A;  4GR3 A;  1AKL A;  2OW9 A;  1MMB A;  4XBH A;  3RTS A;  1HFC A;  3B2Z A;  3ZXH A;  1WNI A;  2QPJ A;  4FU4 A;  4ON1 A;  1ZXC A;  1ZVX A;  4H84 A;  1JAO A;  4FVL A;  1RMZ A;  1SU3 A;  1BKC I;  2OXU A;  1H71 P;  1GKC A;  2OZR A;  1CXV A;  1YCM A;  1BM6 A;  4G9L A;  3DWB A;  3N2V A;  4IN9 A;  5CUH A;  2JT5 A;  4GWM A;  3KRY A;  3RTT A;  5I43 A;  1QJI A;  1DMT A;  5D7W A;  3HBU P;  4GWN A;  1B8Y A;  3WV2 A;  1D8M A;  2MZI A;  3LK8 A;  1A85 A;  3F15 A;  4G0D A;  1O0Q A;  4HMA A;  1RM8 A;  2X3A A;  1QIB A;  1CK7 A;  3G5C A;  1QIC A;  2JT6 A;  4WF6 A;  1A86 A;  4HX3 A;  3HY9 A;  4PKS A;  4WK7 A;  2YIG A;  1XFZ A;  3AYK A;  1QIA A;  1BKC A;  4PKQ A;  1HFS A;  2FV5 A;  4WZV A;  1I76 A;  4AIG A;  1Z3J A;  3OHO A;  5CZM A;  1K7Q A;  2DW2 A;  1ZTQ A;  2WO9 A;  2E2D A;  1PWU A;  4R3V A;  4GF1 A;  5D3C A;  2OXW A;  1JIW P;  1BZS A;  1D5J A;  1AYK A;  2TCL A;  3WV1 A;  1KBC A;  2X3C A;  4L6T A;  1UEA A;  1HTD A;  2D1O A;  5I12 A;  1BQO A;  2JIH A;  1JIZ A;  1IAB A;  3DNG A;  3LIK A;  4GQL A;  1KAP P;  2RJP A;  2WO8 A;  1UTZ A;  1KUK A;  1SAT A;  4FXY P;  5JMY A;  2OI0 A;  1G9K A;  3F1A A;  3DPE A;  1QUA A;  2Z2D A;  4PKW A;  3EDG A;  2O3E A;  1KUF A;  3WV3 A;  1XUC A;  3GBO A;  1UMT A;  3LIL A;  3F16 A;  1XFY A;  1XFV A;  2OVZ A;  4A7B A;  3VTG A;  4IUW A;  1R1H A;  3TSK A;  1HV5 A;  1S4B P;  4AUO A;  5D1T A;  1Y93 A;  1CIZ A;  1I1I P;  1ZP5 A;  3KMC A;  1ZS0 A;  2ERQ A;  1GKD A;  4XM7 A;  1SLM A;  2SRT A;  1PWP A;  1OO9 A;  3OHL A;  2RJQ A;  2POJ A;  5I4O A;  1UTT A;  4PKT A;  2X7M A;  3U1R A;  3DSL A;  2HU6 A;  1D8F A;  1Y8J A;  1Y0V A;  1JAQ A;  1K7G A;  1SLN A;  5I3M A;  3B8Z A;  1XFU A;  5D1U A;  4XM6 A;  2JNP A;  3K7L A;  5B5O A;  2V4B A;  1AF0 A;  1XFW A;  2W0D A;  3DL1 A;  3KEJ A;  3USN A;  5BOT A;  2CKI A;  1ATL A;  2WOA A;  4XCT A;  3LEA A;  5LAB A;  4JIJ A;  3LQB A;  3NX7 A;  2MZH A;  3F19 A;  1GXD A;  4A3W A;  2W14 A;  1GE7 A;  3VI1 A;  3LGP A;  1OM6 A;  3HDB A;  1B3D A;  2ERP A;  1KUI A;  3CKI A;  2J83 A;  1SMP A;  1MMP A;  4H30 A;  1G4K A;  1G12 A;  2K2G A;  2OW1 A;  3B92 A;  4H2E A;  3UVC A;  4DF9 A;  1GE5 A;  1CGL A;  1UMS A;  1R54 A;  3KEC A;  4JP4 A;  3MA2 A;  4CTH A;  4I03 A;  4AXQ A;  1L6J A;  1JAP A;  5H8X A;  3L0V A;  1HY7 A;  1FM1 A;  1CGE A;  2FV9 A;  4GR8 A;  4H3X A;  5I0L A;  3K7N A;  3HB2 P;  3EDZ A;  3LJG A;  3TVC A;  1OMJ A;  3ZVS A;  456C A;  2CLT A;  2DW1 A;  3LUM A;  4DPE A;  1IAE A;  2L0R A;  3N2U A;  3G42 A;  1O0T A;  2W13 A;  2MLS A;  2Y6C A;  4PKU A;  4WKE A;  4FXQ A;  1IAA A;  4IJO A;  5I2Z A;  4PKV A;  1CAQ A;  3Q2H A;  3LUN A;  3BA0 A;  4EFS A;  1YOU A;  3EHX A;  3TT4 A;  4Q1L A;  3HDA P;  5BPA A;  3KEK A;  3LJZ A;  4ILW D;  5D2B A;  2I47 A;  3I7I A;  1IAG A;  1MMQ A;  4H82 A;  1MNC A;  1XUR A;  1G49 A;  1JKY A;  2USN A;  3F18 A;  2Y6D A;  1I73 A;  3AIG A;  3KHI A;  966C A;  1QJJ A;  4H49 A;  2AYK A;  2J0T A;  3KWV C;  4H1Q A;  2KRJ A;  2X3B A;  3I7G A;  1C8T A;  1ZXV A;  4AYK A;  3Q2G A;  3EWJ A;  1J7N A;  2OY2 A;  3HY7 A;  4GR0 A;  2N8R A;  1EB6 A;  1PWQ A;  2OW2 A;  4DV8 A;  3F17 A;  3P24 A;  1G05 A;  1R1J A;  2D1N A;  3ZUK A;  1AST A;  3SHI A;  5L79 A;  1R1I A;  1YQY A;  1EAK A;  3HYG A;  1BSW A;  1JJ9 A;  1BIW A;  1OM7 A;  4JA1 A;  2YB9 A;  2A8H A;  4J4M A;  2DW0 A;  2OW0 A;  2OY4 A;  5B5P A;  2MZE A;  1PWW A;  4H76 A;  2XS3 A;  1K7I A;  1PWV A;  1BKC E;  4WKI A;  3V96 B;  2W15 A;  1FBL A;  1GO7 P;  1JAN A;  3O64 A;  3LE9 A;  1Q3A A;  2ERO A;  2XS4 A;  1IAD A;  1CQR A;  3EHY A;  3HBV P;  1MMR A;  1HOV A;  1GO8 P;  4ZR5 A;  4DD8 A;  5CXA A;  2OVX A;  3LIR A;  1D7X A;  1C7K A;  1DTH A;  2O36 A;  1OM8 A;  3TS4 A;  2K9C A;  1OS9 A;  3EDH A;  4PKR A;  1GE6 A;  1USN A;  3LKA A;  3DPF A;  4JQG A;  1KUG A;  1JK3 A;  3P1V A;  1JH1 A;  1EUB A;  3LJT A;  1R55 A;  1XFX A; 
#chains in the Genus database with same CATH topology
 2W12 A;  3LMC A;  1ND1 A;  4XM8 A;  1XUD A;  3L0T A;  4L19 A;  2JSD A;  3LQ0 A;  4L63 A;  1IAC A;  1OS2 A;  3ELM A;  5D1S A;  1C3I A;  1ROS A;  4GUY A;  1KUH A;  1FLS A;  2PJT A;  3EDI A;  830C A;  1BQQ M;  1BUD A;  4JPA A;  2DDY A;  1BUV M;  1YP1 A;  5BOY A;  3O2X A;  1CGF A;  2AIG P;  2MLR A;  4QKZ A;  3E8R A;  1SRP A;  3AYU A;  4I35 A;  2OXZ A;  5L7F A;  2E3X A;  3KME A;  3DTK A;  2DDF A;  4GR3 A;  1AKL A;  2OW9 A;  1MMB A;  4XBH A;  3RTS A;  1HFC A;  3B2Z A;  3ZXH A;  1WNI A;  2QPJ A;  4FU4 A;  4ON1 A;  1ZXC A;  1ZVX A;  4H84 A;  1JAO A;  4FVL A;  1RMZ A;  1SU3 A;  1BKC I;  2OXU A;  1H71 P;  1GKC A;  2OZR A;  1CXV A;  1YCM A;  1BM6 A;  4G9L A;  3DWB A;  3N2V A;  4IN9 A;  5CUH A;  2JT5 A;  4GWM A;  3KRY A;  3RTT A;  5I43 A;  1QJI A;  1DMT A;  5D7W A;  3HBU P;  4GWN A;  1B8Y A;  3WV2 A;  1D8M A;  2MZI A;  3LK8 A;  1A85 A;  3F15 A;  4G0D A;  1O0Q A;  4HMA A;  1RM8 A;  2X3A A;  1QIB A;  1CK7 A;  3G5C A;  1QIC A;  2JT6 A;  4WF6 A;  1A86 A;  4HX3 A;  1XAX A;  3HY9 A;  4PKS A;  4WK7 A;  2YIG A;  1XFZ A;  3AYK A;  1QIA A;  1BKC A;  4PKQ A;  1HFS A;  2FV5 A;  4WZV A;  1I76 A;  4AIG A;  1Z3J A;  3OHO A;  5CZM A;  1K7Q A;  2DW2 A;  1ZTQ A;  2WO9 A;  2E2D A;  1PWU A;  4R3V A;  4GF1 A;  5D3C A;  2OXW A;  1JIW P;  1BZS A;  1D5J A;  1AYK A;  2TCL A;  3WV1 A;  1KBC A;  2X3C A;  4L6T A;  1UEA A;  1HTD A;  2D1O A;  5I12 A;  1BQO A;  2JIH A;  1JIZ A;  1IAB A;  3DNG A;  3LIK A;  4GQL A;  1KAP P;  2RJP A;  2WO8 A;  1UTZ A;  1KUK A;  1SAT A;  4FXY P;  5JMY A;  2OI0 A;  1G9K A;  3F1A A;  3DPE A;  1QUA A;  2Z2D A;  4PKW A;  3EDG A;  2O3E A;  1KUF A;  3WV3 A;  1XUC A;  3GBO A;  1UMT A;  3LIL A;  3F16 A;  1XFY A;  1XFV A;  2OVZ A;  4A7B A;  3VTG A;  4IUW A;  1R1H A;  3TSK A;  1HV5 A;  1S4B P;  4AUO A;  5D1T A;  1Y93 A;  1CIZ A;  1I1I P;  1ZP5 A;  3KMC A;  1ZS0 A;  2ERQ A;  1GKD A;  4XM7 A;  3DTI A;  1SLM A;  2SRT A;  1PWP A;  1OO9 A;  3OHL A;  2RJQ A;  2POJ A;  5I4O A;  1UTT A;  4PKT A;  2X7M A;  3U1R A;  3DSL A;  2HU6 A;  1D8F A;  1Y8J A;  1Y0V A;  1JAQ A;  1K7G A;  1SLN A;  5I3M A;  3B8Z A;  1XFU A;  5D1U A;  4XM6 A;  2JNP A;  3K7L A;  5B5O A;  2V4B A;  1AF0 A;  1XFW A;  2W0D A;  3DL1 A;  3KEJ A;  3USN A;  5BOT A;  2CKI A;  1ATL A;  2WOA A;  4XCT A;  3LEA A;  5LAB A;  4JIJ A;  3LQB A;  3NX7 A;  2MZH A;  3F19 A;  1GXD A;  4A3W A;  2W14 A;  1GE7 A;  3VI1 A;  3LGP A;  1OM6 A;  3HDB A;  1OZ9 A;  1B3D A;  2ERP A;  1KUI A;  3CKI A;  2J83 A;  1SMP A;  1MMP A;  4H30 A;  1G4K A;  1G12 A;  2K2G A;  2OW1 A;  3B92 A;  4H2E A;  3UVC A;  4DF9 A;  1GE5 A;  1CGL A;  1UMS A;  1R54 A;  3KEC A;  4JP4 A;  3MA2 A;  4CTH A;  4I03 A;  4AXQ A;  1L6J A;  1JAP A;  5H8X A;  3L0V A;  1HY7 A;  1FM1 A;  1CGE A;  1XM5 A;  2FV9 A;  4GR8 A;  4H3X A;  5I0L A;  3K7N A;  3HB2 P;  3EDZ A;  3LJG A;  3TVC A;  1OMJ A;  3DTE A;  3ZVS A;  456C A;  2CLT A;  2DW1 A;  3LUM A;  4DPE A;  1IAE A;  2L0R A;  3N2U A;  3G42 A;  1O0T A;  2W13 A;  2MLS A;  2Y6C A;  4PKU A;  4WKE A;  4FXQ A;  1IAA A;  4IJO A;  5I2Z A;  4PKV A;  1CAQ A;  3Q2H A;  3LUN A;  3BA0 A;  4EFS A;  1YOU A;  3EHX A;  3TT4 A;  4Q1L A;  3HDA P;  5BPA A;  3KEK A;  3LJZ A;  4ILW D;  5D2B A;  2I47 A;  3I7I A;  1IAG A;  1MMQ A;  4H82 A;  1MNC A;  1XUR A;  1G49 A;  1JKY A;  2USN A;  3F18 A;  2Y6D A;  1I73 A;  3AIG A;  3KHI A;  966C A;  1QJJ A;  4H49 A;  2AYK A;  2J0T A;  3KWV C;  4H1Q A;  2KRJ A;  2X3B A;  3I7G A;  1C8T A;  1ZXV A;  4AYK A;  3Q2G A;  3EWJ A;  1J7N A;  2OY2 A;  3HY7 A;  4GR0 A;  2N8R A;  1EB6 A;  1PWQ A;  2OW2 A;  4DV8 A;  2YUF A;  3F17 A;  3P24 A;  1G05 A;  1R1J A;  2D1N A;  3ZUK A;  1AST A;  3SHI A;  5L79 A;  1TVI A;  1R1I A;  1YQY A;  1EAK A;  3HYG A;  1BSW A;  1JJ9 A;  1BIW A;  1OM7 A;  4JA1 A;  2YB9 A;  2A8H A;  4J4M A;  2DW0 A;  2OW0 A;  2OY4 A;  5B5P A;  2MZE A;  1PWW A;  4H76 A;  2XS3 A;  1K7I A;  1PWV A;  4L7A A;  1BKC E;  4WKI A;  3V96 B;  2W15 A;  1FBL A;  1GO7 P;  1JAN A;  3O64 A;  3LE9 A;  1Q3A A;  2ERO A;  2XS4 A;  1IAD A;  1CQR A;  3EHY A;  3HBV P;  1MMR A;  1HOV A;  1GO8 P;  4ZR5 A;  4DD8 A;  5CXA A;  2OVX A;  3LIR A;  1D7X A;  1C7K A;  1DTH A;  2O36 A;  1OM8 A;  3TS4 A;  2K9C A;  1OS9 A;  3EDH A;  4PKR A;  1GE6 A;  1USN A;  3LKA A;  3DPF A;  4JQG A;  1KUG A;  1JK3 A;  3P1V A;  1JH1 A;  1EUB A;  3LJT A;  1R55 A;  1XFX A; 
#chains in the Genus database with same CATH homology
 2W12 A;  3LMC A;  1ND1 A;  4XM8 A;  1XUD A;  3L0T A;  4L19 A;  2JSD A;  3LQ0 A;  4L63 A;  1IAC A;  1OS2 A;  3ELM A;  5D1S A;  1C3I A;  1ROS A;  4GUY A;  1KUH A;  1FLS A;  2PJT A;  3EDI A;  830C A;  1BQQ M;  1BUD A;  4JPA A;  2DDY A;  1BUV M;  1YP1 A;  5BOY A;  3O2X A;  1CGF A;  2AIG P;  2MLR A;  4QKZ A;  3E8R A;  1SRP A;  3AYU A;  4I35 A;  2OXZ A;  5L7F A;  2E3X A;  3KME A;  3DTK A;  2DDF A;  4GR3 A;  1AKL A;  2OW9 A;  1MMB A;  4XBH A;  3RTS A;  1HFC A;  3B2Z A;  3ZXH A;  1WNI A;  2QPJ A;  4FU4 A;  4ON1 A;  1ZXC A;  1ZVX A;  4H84 A;  1JAO A;  4FVL A;  1RMZ A;  1SU3 A;  1BKC I;  2OXU A;  1H71 P;  1GKC A;  2OZR A;  1CXV A;  1YCM A;  1BM6 A;  4G9L A;  3DWB A;  3N2V A;  4IN9 A;  5CUH A;  2JT5 A;  4GWM A;  3KRY A;  3RTT A;  5I43 A;  1QJI A;  1DMT A;  5D7W A;  3HBU P;  4GWN A;  1B8Y A;  3WV2 A;  1D8M A;  2MZI A;  3LK8 A;  1A85 A;  3F15 A;  4G0D A;  1O0Q A;  4HMA A;  1RM8 A;  2X3A A;  1QIB A;  1CK7 A;  3G5C A;  1QIC A;  2JT6 A;  4WF6 A;  1A86 A;  4HX3 A;  3HY9 A;  4PKS A;  4WK7 A;  2YIG A;  1XFZ A;  3AYK A;  1QIA A;  1BKC A;  4PKQ A;  1HFS A;  2FV5 A;  4WZV A;  1I76 A;  4AIG A;  1Z3J A;  3OHO A;  5CZM A;  1K7Q A;  2DW2 A;  1ZTQ A;  2WO9 A;  2E2D A;  1PWU A;  4R3V A;  4GF1 A;  5D3C A;  2OXW A;  1JIW P;  1BZS A;  1D5J A;  1AYK A;  2TCL A;  3WV1 A;  1KBC A;  2X3C A;  4L6T A;  1UEA A;  1HTD A;  2D1O A;  5I12 A;  1BQO A;  2JIH A;  1JIZ A;  1IAB A;  3DNG A;  3LIK A;  4GQL A;  1KAP P;  2RJP A;  2WO8 A;  1UTZ A;  1KUK A;  1SAT A;  4FXY P;  5JMY A;  2OI0 A;  1G9K A;  3F1A A;  3DPE A;  1QUA A;  2Z2D A;  4PKW A;  3EDG A;  2O3E A;  1KUF A;  3WV3 A;  1XUC A;  3GBO A;  1UMT A;  3LIL A;  3F16 A;  1XFY A;  1XFV A;  2OVZ A;  4A7B A;  3VTG A;  4IUW A;  1R1H A;  3TSK A;  1HV5 A;  1S4B P;  4AUO A;  5D1T A;  1Y93 A;  1CIZ A;  1I1I P;  1ZP5 A;  3KMC A;  1ZS0 A;  2ERQ A;  1GKD A;  4XM7 A;  3DTI A;  1SLM A;  2SRT A;  1PWP A;  1OO9 A;  3OHL A;  2RJQ A;  2POJ A;  5I4O A;  1UTT A;  4PKT A;  2X7M A;  3U1R A;  3DSL A;  2HU6 A;  1D8F A;  1Y8J A;  1Y0V A;  1JAQ A;  1K7G A;  1SLN A;  5I3M A;  3B8Z A;  1XFU A;  5D1U A;  4XM6 A;  2JNP A;  3K7L A;  5B5O A;  2V4B A;  1AF0 A;  1XFW A;  2W0D A;  3DL1 A;  3KEJ A;  3USN A;  5BOT A;  2CKI A;  1ATL A;  2WOA A;  4XCT A;  3LEA A;  5LAB A;  4JIJ A;  3LQB A;  3NX7 A;  2MZH A;  3F19 A;  1GXD A;  4A3W A;  2W14 A;  1GE7 A;  3VI1 A;  3LGP A;  1OM6 A;  3HDB A;  1B3D A;  2ERP A;  1KUI A;  3CKI A;  2J83 A;  1SMP A;  1MMP A;  4H30 A;  1G4K A;  1G12 A;  2K2G A;  2OW1 A;  3B92 A;  4H2E A;  3UVC A;  4DF9 A;  1GE5 A;  1CGL A;  1UMS A;  1R54 A;  3KEC A;  4JP4 A;  3MA2 A;  4CTH A;  4I03 A;  4AXQ A;  1L6J A;  1JAP A;  5H8X A;  3L0V A;  1HY7 A;  1FM1 A;  1CGE A;  2FV9 A;  4GR8 A;  4H3X A;  5I0L A;  3K7N A;  3HB2 P;  3EDZ A;  3LJG A;  3TVC A;  1OMJ A;  3DTE A;  3ZVS A;  456C A;  2CLT A;  2DW1 A;  3LUM A;  4DPE A;  1IAE A;  2L0R A;  3N2U A;  3G42 A;  1O0T A;  2W13 A;  2MLS A;  2Y6C A;  4PKU A;  4WKE A;  4FXQ A;  1IAA A;  4IJO A;  5I2Z A;  4PKV A;  1CAQ A;  3Q2H A;  3LUN A;  3BA0 A;  4EFS A;  1YOU A;  3EHX A;  3TT4 A;  4Q1L A;  3HDA P;  5BPA A;  3KEK A;  3LJZ A;  4ILW D;  5D2B A;  2I47 A;  3I7I A;  1IAG A;  1MMQ A;  4H82 A;  1MNC A;  1XUR A;  1G49 A;  1JKY A;  2USN A;  3F18 A;  2Y6D A;  1I73 A;  3AIG A;  3KHI A;  966C A;  1QJJ A;  4H49 A;  2AYK A;  2J0T A;  3KWV C;  4H1Q A;  2KRJ A;  2X3B A;  3I7G A;  1C8T A;  1ZXV A;  4AYK A;  3Q2G A;  3EWJ A;  1J7N A;  2OY2 A;  3HY7 A;  4GR0 A;  2N8R A;  1EB6 A;  1PWQ A;  2OW2 A;  4DV8 A;  2YUF A;  3F17 A;  3P24 A;  1G05 A;  1R1J A;  2D1N A;  3ZUK A;  1AST A;  3SHI A;  5L79 A;  1R1I A;  1YQY A;  1EAK A;  3HYG A;  1BSW A;  1JJ9 A;  1BIW A;  1OM7 A;  4JA1 A;  2YB9 A;  2A8H A;  4J4M A;  2DW0 A;  2OW0 A;  2OY4 A;  5B5P A;  2MZE A;  1PWW A;  4H76 A;  2XS3 A;  1K7I A;  1PWV A;  4L7A A;  1BKC E;  4WKI A;  3V96 B;  2W15 A;  1FBL A;  1GO7 P;  1JAN A;  3O64 A;  3LE9 A;  1Q3A A;  2ERO A;  2XS4 A;  1IAD A;  1CQR A;  3EHY A;  3HBV P;  1MMR A;  1HOV A;  1GO8 P;  4ZR5 A;  4DD8 A;  5CXA A;  2OVX A;  3LIR A;  1D7X A;  1C7K A;  1DTH A;  2O36 A;  1OM8 A;  3TS4 A;  2K9C A;  1OS9 A;  3EDH A;  4PKR A;  1GE6 A;  1USN A;  3LKA A;  3DPF A;  4JQG A;  1KUG A;  1JK3 A;  3P1V A;  1JH1 A;  1EUB A;  3LJT A;  1R55 A;  1XFX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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