3B92A

Novel thio-based tace inhibitors part 2: rational design, synthesis and sar of thiol-contaning aryl sufones
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
259
structure length
259
Chain Sequence
ADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords ADAM 17
total genus 83
structure length 259
sequence length 259
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2007-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3b92A00
2OVZA 1AKLA 3U1RA 5I4OA 3ELMA 4PKRA 4DD8A 3NX7A 1R1HA 3KMCA 4WK7A 2D1NA 4FU4A 1USNA 1I73A 3KHIA 3RTSA 3K7LA 5I12A 2K2GA 1O0QA 4GF1A 1BUVM 3LEAA 1GE7A 4L19A 3LILA 3DSLA 1YP1A 3ZVSA 1CGFA 1XFWA 1FLSA 1JJ9A 3DNGA 4HX3A 5I0LA 3HY9A 4PKUA 1IACA 1GE5A 2E2DA 1JKYA 966CA 1Z3JA 1IABA 4JQGA 1BM6A 3V96B 3HDBA 2OY2A 4HMAA 2SRTA 1ZVXA 2X7MA 1ZXVA 2PJTA 3EHYA 2J83A 3F19A 2OY4A 1WNIA 4AIGA 1AF0A 1R1JA 1C3IA 1XFXA 1GXDA 3KRYA 1YCMA 4WKEA 1GO8P 2JNPA 1ROSA 4H2EA 2N8RA 1QIBA 2W14A 4PKQA 3G42A 3F16A 1SATA 1EAKA 1CAQA 1L6JA 3WV1A 4Q1LA 1D8MA 1KUIA 5BPAA 2RJQA 2FV9A 4GWNA 2YIGA 4I03A 2HU6A 1OM6A 1QICA 1OMJA 4FXYP 4XM7A 2OW9A 3EDHA 1XFUA 1OS2A 1YQYA 3LJZA 4J4MA 4JP4A 1MMRA 1OM7A 2W13A 1BKCI 1KUHA 3TVCA 1HV5A 4L63A 2WO8A 2W0DA 3GBOA 1IAGA 1I76A 3VI1A 1BKCA 1ZXCA 3KEKA 3E8RA 3KEJA 1R1IA 1JANA 4H84A 1PWWA 3KECA 2J0TA 1CIZA 1PWUA 2L0RA 3HYGA 1Q3AA 1SMPA 3N2VA 3F15A 3LJTA 1JAQA 4XCTA 1QJIA 1GO7P 1BQQM 4A7BA 1BZSA 4XM6A 1RMZA 2ERPA 2FV5A 5CZMA 4GR0A 3SHIA 3N2UA 1UEAA 2WO9A 2DW1A 4EFSA 456CA 3EDZA 2MZEA 1JK3A 3TT4A 2OW0A 1DMTA 5JMYA 1D5JA 3AYKA 1YOUA 3KMEA 1MNCA 3EWJA 1AYKA 1JAPA 3RTTA 5D1UA 1D8FA 3HDAP 4IN9A 5H8XA 1JIZA 5L7FA 1SLNA 1GKCA 1CXVA 3HB2P 3DL1A 1QUAA 2JSDA 4AXQA 1UTTA 2CLTA 5I2ZA 1GKDA 1OS9A 4GR3A 4PKVA 1BQOA 1SU3A 1PWVA 830CA 4JIJA 3LUNA 5D1SA 5I3MA 2KRJA 4L6TA 5BOTA 4R3VA 1H71P 3KWVC 3BA0A 3I7GA 1IADA 2Y6CA 2CKIA 2O3EA 1FM1A 4H1QA 1ZP5A 1XURA 3UVCA 1IAEA 1HFSA 3F18A 1KBCA 1DTHA 5D3CA 4FXQA 2XS3A 3K7NA 2MLSA 1UMSA 2AYKA 2JT5A 4XM8A 4GR8A 3F1AA 3LIRA 5CXAA 3I7IA 3AYUA 3HY7A 5D7WA 1D7XA 2JT6A 1HTDA 1O0TA 2MZHA 3L0TA 5B5PA 1EB6A 1B3DA 1JH1A 2OW2A 2MZIA 1CGLA 3DWBA 1J7NA 5D2BA 4IJOA 1KUGA 3DPFA 4DF9A 1R55A 1XUDA 4WKIA 3AIGA 1IAAA 1BKCE 4JPAA 1G05A 2YB9A 1ZS0A 1K7QA 1XFZA 5CUHA 2TCLA 2OW1A 2JIHA 4DV8A 3MA2A 1R54A 4ZR5A 4PKWA 1OM8A 1BSWA 4G9LA 1OO9A 3O64A 4G0DA 4AUOA 4GQLA 1CQRA 1GE6A 3LMCA 1XFVA 4GWMA 3Q2HA 4H30A 2OXZA 1C7KA 2OXWA 3LQBA 1ND1A 1UTZA 1Y8JA 1A86A 4PKTA 2I47A 2X3AA 1HY7A 3O2XA 1SRPA 2POJA 1ZTQA 1PWQA 1CGEA 4H49A 3EDGA 3LQ0A 4GUYA 2WOAA 2OXUA 2DDFA 1QIAA 3Q2GA 5D1TA 2V4BA 1MMPA 1MMBA 1JIWP 1JAOA 2MLRA 4WZVA 1MMQA 1KUFA 5BOYA 3OHLA 1KUKA 1RM8A 3LIKA 2X3CA 4H3XA 4XBHA 3ZUKA 1B8YA 3B92A 4AYKA 5B5OA 3G5CA 1G49A 2AIGP 3P1VA 2QPJA 2RJPA 4H82A 3WV2A 3LKAA 1UMTA 1XFYA 2OZRA 3B8ZA 1CK7A 2XS4A 3LUMA 1A85A 1BUDA 4H76A 4QKZA 2A8HA 1BIWA 2USNA 1I1IP 1G9KA 1PWPA 2D1OA 2EROA 3OHOA 1K7IA 3LK8A 5LABA 1HFCA 3USNA 3LJGA 4PKSA 4IUWA 3CKIA 3L0VA 4FVLA 1G4KA 2ERQA 2O36A 5I43A 2E3XA 3HBVP 3LE9A 1SLMA 3LGPA 1HOVA 2OI0A 4WF6A 3P24A 1EUBA 2W15A 4I35A 3B2ZA 1KAPP 3VTGA 2DDYA 1C8TA 3TSKA 2K9CA 1ASTA 4ILWD 4DPEA 3TS4A 2OVXA 1G12A 1FBLA 1Y0VA 2DW0A 4ON1A 1XUCA 3HBUP 1ATLA 3F17A 2W12A 4JA1A 4CTHA 1K7GA 3EDIA 3ZXHA 3WV3A 1QJJA 2DW2A 4A3WA 5L79A 2X3BA 1S4BP 2Z2DA 3DPEA 2Y6DA 1Y93A 3EHXA
chains in the Genus database with same CATH superfamily
2OVZA 1AKLA 3U1RA 5I4OA 3ELMA 4PKRA 4DD8A 3NX7A 1R1HA 3KMCA 4WK7A 2D1NA 4FU4A 1USNA 1I73A 3KHIA 3RTSA 3K7LA 5I12A 2K2GA 1O0QA 4GF1A 1BUVM 3LEAA 1GE7A 4L19A 3LILA 3DSLA 1YP1A 3ZVSA 2YUFA 1CGFA 1XFWA 1FLSA 1JJ9A 3DNGA 4HX3A 5I0LA 3HY9A 4PKUA 1IACA 1GE5A 2E2DA 1JKYA 966CA 3DTKA 1Z3JA 1IABA 4JQGA 1BM6A 3V96B 3HDBA 2OY2A 4HMAA 2SRTA 1ZVXA 2X7MA 1ZXVA 2PJTA 3EHYA 2J83A 3F19A 2OY4A 1WNIA 4AIGA 1AF0A 1R1JA 1C3IA 1XFXA 1GXDA 3KRYA 1YCMA 4WKEA 1GO8P 2JNPA 1ROSA 4H2EA 2N8RA 1QIBA 2W14A 4PKQA 3G42A 3F16A 1SATA 1EAKA 1CAQA 1L6JA 3WV1A 4Q1LA 1D8MA 1KUIA 5BPAA 2RJQA 2FV9A 4GWNA 2YIGA 4I03A 2HU6A 1OM6A 1QICA 1OMJA 4FXYP 4XM7A 2OW9A 3EDHA 1XFUA 1OS2A 1YQYA 3LJZA 4J4MA 4JP4A 1MMRA 1OM7A 2W13A 1BKCI 1KUHA 3TVCA 1HV5A 4L63A 2WO8A 2W0DA 3GBOA 1IAGA 1I76A 3VI1A 1BKCA 1ZXCA 3KEKA 3E8RA 3KEJA 1R1IA 1JANA 4H84A 1PWWA 3KECA 2J0TA 1CIZA 1PWUA 2L0RA 3HYGA 1Q3AA 1SMPA 3N2VA 3F15A 3LJTA 1JAQA 4XCTA 1QJIA 1GO7P 1BQQM 4A7BA 1BZSA 4XM6A 1RMZA 2ERPA 2FV5A 5CZMA 4GR0A 3SHIA 3N2UA 1UEAA 2WO9A 2DW1A 4EFSA 456CA 3EDZA 2MZEA 1JK3A 3TT4A 2OW0A 1DMTA 5JMYA 1D5JA 3AYKA 1YOUA 3KMEA 1MNCA 3EWJA 1AYKA 1JAPA 3RTTA 5D1UA 1D8FA 3HDAP 4IN9A 5H8XA 1JIZA 5L7FA 1SLNA 1GKCA 1CXVA 3HB2P 3DL1A 1QUAA 2JSDA 4AXQA 1UTTA 2CLTA 5I2ZA 1GKDA 1OS9A 4GR3A 4PKVA 1BQOA 1SU3A 1PWVA 830CA 4JIJA 3LUNA 5D1SA 5I3MA 2KRJA 4L6TA 5BOTA 4R3VA 1H71P 3KWVC 3BA0A 3I7GA 1IADA 2Y6CA 2CKIA 2O3EA 1FM1A 4H1QA 1ZP5A 1XURA 3UVCA 1IAEA 1HFSA 3F18A 1KBCA 1DTHA 5D3CA 4FXQA 2XS3A 3K7NA 2MLSA 1UMSA 2AYKA 2JT5A 4XM8A 4GR8A 3F1AA 3LIRA 5CXAA 3I7IA 3AYUA 3HY7A 5D7WA 1D7XA 1TVIA 2JT6A 1HTDA 1O0TA 2MZHA 3L0TA 5B5PA 1EB6A 1B3DA 1JH1A 2OW2A 2MZIA 1CGLA 3DWBA 1J7NA 5D2BA 4IJOA 1KUGA 3DPFA 4DF9A 1R55A 1XUDA 4WKIA 3AIGA 1IAAA 1BKCE 4JPAA 1G05A 2YB9A 1ZS0A 1K7QA 1XFZA 5CUHA 2TCLA 2OW1A 2JIHA 4DV8A 3MA2A 1R54A 4ZR5A 4PKWA 1OM8A 1BSWA 4G9LA 1OO9A 3O64A 4G0DA 4AUOA 4GQLA 1CQRA 1GE6A 3LMCA 1XFVA 4GWMA 3Q2HA 4H30A 2OXZA 1C7KA 2OXWA 3LQBA 1ND1A 1UTZA 1Y8JA 1A86A 4PKTA 2I47A 2X3AA 1HY7A 3O2XA 1SRPA 2POJA 1ZTQA 1PWQA 1CGEA 4H49A 3EDGA 3LQ0A 4GUYA 2WOAA 2OXUA 2DDFA 1QIAA 3Q2GA 5D1TA 2V4BA 1MMPA 1MMBA 1JIWP 1XAXA 1JAOA 1XM5A 2MLRA 4WZVA 1MMQA 1KUFA 5BOYA 3OHLA 1KUKA 1RM8A 3LIKA 2X3CA 4H3XA 4XBHA 3ZUKA 1B8YA 3B92A 4AYKA 5B5OA 3G5CA 1G49A 2AIGP 3P1VA 2QPJA 2RJPA 4H82A 3WV2A 3LKAA 1UMTA 1XFYA 2OZRA 3B8ZA 1CK7A 2XS4A 3LUMA 1A85A 1BUDA 4H76A 4QKZA 2A8HA 1BIWA 2USNA 1I1IP 1G9KA 1PWPA 2D1OA 2EROA 3OHOA 1K7IA 3LK8A 5LABA 1HFCA 1OZ9A 3USNA 3LJGA 4PKSA 4IUWA 3CKIA 3L0VA 4FVLA 1G4KA 2ERQA 2O36A 5I43A 2E3XA 3HBVP 3LE9A 1SLMA 3LGPA 1HOVA 2OI0A 4WF6A 3P24A 1EUBA 2W15A 4I35A 3B2ZA 1KAPP 3VTGA 2DDYA 1C8TA 3TSKA 2K9CA 1ASTA 3DTEA 4ILWD 4DPEA 3TS4A 2OVXA 1G12A 1FBLA 1Y0VA 2DW0A 4ON1A 1XUCA 3HBUP 1ATLA 3F17A 2W12A 4JA1A 4CTHA 1K7GA 3EDIA 3DTIA 3ZXHA 3WV3A 1QJJA 2DW2A 4A3WA 5L79A 2X3BA 1S4BP 2Z2DA 3DPEA 2Y6DA 1Y93A 4L7AA 3EHXA
chains in the Genus database with same CATH topology
2OVZA 1AKLA 3U1RA 5I4OA 3ELMA 4PKRA 4DD8A 3NX7A 1R1HA 3KMCA 4WK7A 2D1NA 4FU4A 1USNA 1I73A 3KHIA 3RTSA 3K7LA 5I12A 2K2GA 1O0QA 4GF1A 1BUVM 3LEAA 1GE7A 4L19A 3LILA 3DSLA 1YP1A 3ZVSA 2YUFA 1CGFA 1XFWA 1FLSA 1JJ9A 3DNGA 4HX3A 5I0LA 3HY9A 4PKUA 1IACA 1GE5A 2E2DA 1JKYA 966CA 3DTKA 1Z3JA 1IABA 4JQGA 1BM6A 3V96B 3HDBA 2OY2A 4HMAA 2SRTA 1ZVXA 2X7MA 1ZXVA 2PJTA 3EHYA 2J83A 3F19A 2OY4A 1WNIA 4AIGA 1AF0A 1R1JA 1C3IA 1XFXA 1GXDA 3KRYA 1YCMA 4WKEA 1GO8P 2JNPA 1ROSA 4H2EA 2N8RA 1QIBA 2W14A 4PKQA 3G42A 3F16A 1SATA 1EAKA 1CAQA 1L6JA 3WV1A 4Q1LA 1D8MA 1KUIA 5BPAA 2RJQA 2FV9A 4GWNA 2YIGA 4I03A 2HU6A 1OM6A 1QICA 1OMJA 4FXYP 4XM7A 2OW9A 3EDHA 1XFUA 1OS2A 1YQYA 3LJZA 4J4MA 4JP4A 1MMRA 1OM7A 2W13A 1BKCI 1KUHA 3TVCA 1HV5A 4L63A 2WO8A 2W0DA 3GBOA 1IAGA 1I76A 3VI1A 1BKCA 1ZXCA 3KEKA 3E8RA 3KEJA 1R1IA 1JANA 4H84A 1PWWA 3KECA 2J0TA 1CIZA 1PWUA 2L0RA 3HYGA 1Q3AA 1SMPA 3N2VA 3F15A 3LJTA 1JAQA 4XCTA 1QJIA 1GO7P 1BQQM 4A7BA 1BZSA 4XM6A 1RMZA 2ERPA 2FV5A 5CZMA 4GR0A 3SHIA 3N2UA 1UEAA 2WO9A 2DW1A 4EFSA 456CA 3EDZA 2MZEA 1JK3A 3TT4A 2OW0A 1DMTA 5JMYA 1D5JA 3AYKA 1YOUA 3KMEA 1MNCA 3EWJA 1AYKA 1JAPA 3RTTA 5D1UA 1D8FA 3HDAP 4IN9A 5H8XA 1JIZA 5L7FA 1SLNA 1GKCA 1CXVA 3HB2P 3DL1A 1QUAA 2JSDA 4AXQA 1UTTA 2CLTA 5I2ZA 1GKDA 1OS9A 4GR3A 4PKVA 1BQOA 1SU3A 1PWVA 830CA 4JIJA 3LUNA 5D1SA 5I3MA 2KRJA 4L6TA 5BOTA 4R3VA 1H71P 3KWVC 3BA0A 3I7GA 1IADA 2Y6CA 2CKIA 2O3EA 1FM1A 4H1QA 1ZP5A 1XURA 3UVCA 1IAEA 1HFSA 3F18A 1KBCA 1DTHA 5D3CA 4FXQA 2XS3A 3K7NA 2MLSA 1UMSA 2AYKA 2JT5A 4XM8A 4GR8A 3F1AA 3LIRA 5CXAA 3I7IA 3AYUA 3HY7A 5D7WA 1D7XA 2JT6A 1HTDA 1O0TA 2MZHA 3L0TA 5B5PA 1EB6A 1B3DA 1JH1A 2OW2A 2MZIA 1CGLA 3DWBA 1J7NA 5D2BA 4IJOA 1KUGA 3DPFA 4DF9A 1R55A 1XUDA 4WKIA 3AIGA 1IAAA 1BKCE 4JPAA 1G05A 2YB9A 1ZS0A 1K7QA 1XFZA 5CUHA 2TCLA 2OW1A 2JIHA 4DV8A 3MA2A 1R54A 4ZR5A 4PKWA 1OM8A 1BSWA 4G9LA 1OO9A 3O64A 4G0DA 4AUOA 4GQLA 1CQRA 1GE6A 3LMCA 1XFVA 4GWMA 3Q2HA 4H30A 2OXZA 1C7KA 2OXWA 3LQBA 1ND1A 1UTZA 1Y8JA 1A86A 4PKTA 2I47A 2X3AA 1HY7A 3O2XA 1SRPA 2POJA 1ZTQA 1PWQA 1CGEA 4H49A 3EDGA 3LQ0A 4GUYA 2WOAA 2OXUA 2DDFA 1QIAA 3Q2GA 5D1TA 2V4BA 1MMPA 1MMBA 1JIWP 1JAOA 2MLRA 4WZVA 1MMQA 1KUFA 5BOYA 3OHLA 1KUKA 1RM8A 3LIKA 2X3CA 4H3XA 4XBHA 3ZUKA 1B8YA 3B92A 4AYKA 5B5OA 3G5CA 1G49A 2AIGP 3P1VA 2QPJA 2RJPA 4H82A 3WV2A 3LKAA 1UMTA 1XFYA 2OZRA 3B8ZA 1CK7A 2XS4A 3LUMA 1A85A 1BUDA 4H76A 4QKZA 2A8HA 1BIWA 2USNA 1I1IP 1G9KA 1PWPA 2D1OA 2EROA 3OHOA 1K7IA 3LK8A 5LABA 1HFCA 3USNA 3LJGA 4PKSA 4IUWA 3CKIA 3L0VA 4FVLA 1G4KA 2ERQA 2O36A 5I43A 2E3XA 3HBVP 3LE9A 1SLMA 3LGPA 1HOVA 2OI0A 4WF6A 3P24A 1EUBA 2W15A 4I35A 3B2ZA 1KAPP 3VTGA 2DDYA 1C8TA 3TSKA 2K9CA 1ASTA 3DTEA 4ILWD 4DPEA 3TS4A 2OVXA 1G12A 1FBLA 1Y0VA 2DW0A 4ON1A 1XUCA 3HBUP 1ATLA 3F17A 2W12A 4JA1A 4CTHA 1K7GA 3EDIA 3DTIA 3ZXHA 3WV3A 1QJJA 2DW2A 4A3WA 5L79A 2X3BA 1S4BP 2Z2DA 3DPEA 2Y6DA 1Y93A 4L7AA 3EHXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OVZ A;  1AKL A;  3U1R A;  5I4O A;  3ELM A;  4PKR A;  4DD8 A;  3NX7 A;  1R1H A;  3KMC A;  4WK7 A;  2D1N A;  4FU4 A;  1USN A;  1I73 A;  3KHI A;  3RTS A;  3K7L A;  5I12 A;  2K2G A;  1O0Q A;  4GF1 A;  1BUV M;  3LEA A;  1GE7 A;  4L19 A;  3LIL A;  3DSL A;  1YP1 A;  3ZVS A;  1CGF A;  1XFW A;  1FLS A;  1JJ9 A;  3DNG A;  4HX3 A;  5I0L A;  3HY9 A;  4PKU A;  1IAC A;  1GE5 A;  2E2D A;  1JKY A;  966C A;  1Z3J A;  1IAB A;  4JQG A;  1BM6 A;  3V96 B;  3HDB A;  2OY2 A;  4HMA A;  2SRT A;  1ZVX A;  2X7M A;  1ZXV A;  2PJT A;  3EHY A;  2J83 A;  3F19 A;  2OY4 A;  1WNI A;  4AIG A;  1AF0 A;  1R1J A;  1C3I A;  1XFX A;  1GXD A;  3KRY A;  1YCM A;  4WKE A;  1GO8 P;  2JNP A;  1ROS A;  4H2E A;  2N8R A;  1QIB A;  2W14 A;  4PKQ A;  3G42 A;  3F16 A;  1SAT A;  1EAK A;  1CAQ A;  1L6J A;  3WV1 A;  4Q1L A;  1D8M A;  1KUI A;  5BPA A;  2RJQ A;  2FV9 A;  4GWN A;  2YIG A;  4I03 A;  2HU6 A;  1OM6 A;  1QIC A;  1OMJ A;  4FXY P;  4XM7 A;  2OW9 A;  3EDH A;  1XFU A;  1OS2 A;  1YQY A;  3LJZ A;  4J4M A;  4JP4 A;  1MMR A;  1OM7 A;  2W13 A;  1BKC I;  1KUH A;  3TVC A;  1HV5 A;  4L63 A;  2WO8 A;  2W0D A;  3GBO A;  1IAG A;  1I76 A;  3VI1 A;  1BKC A;  1ZXC A;  3KEK A;  3E8R A;  3KEJ A;  1R1I A;  1JAN A;  4H84 A;  1PWW A;  3KEC A;  2J0T A;  1CIZ A;  1PWU A;  2L0R A;  3HYG A;  1Q3A A;  1SMP A;  3N2V A;  3F15 A;  3LJT A;  1JAQ A;  4XCT A;  1QJI A;  1GO7 P;  1BQQ M;  4A7B A;  1BZS A;  4XM6 A;  1RMZ A;  2ERP A;  2FV5 A;  5CZM A;  4GR0 A;  3SHI A;  3N2U A;  1UEA A;  2WO9 A;  2DW1 A;  4EFS A;  456C A;  3EDZ A;  2MZE A;  1JK3 A;  3TT4 A;  2OW0 A;  1DMT A;  5JMY A;  1D5J A;  3AYK A;  1YOU A;  3KME A;  1MNC A;  3EWJ A;  1AYK A;  1JAP A;  3RTT A;  5D1U A;  1D8F A;  3HDA P;  4IN9 A;  5H8X A;  1JIZ A;  5L7F A;  1SLN A;  1GKC A;  1CXV A;  3HB2 P;  3DL1 A;  1QUA A;  2JSD A;  4AXQ A;  1UTT A;  2CLT A;  5I2Z A;  1GKD A;  1OS9 A;  4GR3 A;  4PKV A;  1BQO A;  1SU3 A;  1PWV A;  830C A;  4JIJ A;  3LUN A;  5D1S A;  5I3M A;  2KRJ A;  4L6T A;  5BOT A;  4R3V A;  1H71 P;  3KWV C;  3BA0 A;  3I7G A;  1IAD A;  2Y6C A;  2CKI A;  2O3E A;  1FM1 A;  4H1Q A;  1ZP5 A;  1XUR A;  3UVC A;  1IAE A;  1HFS A;  3F18 A;  1KBC A;  1DTH A;  5D3C A;  4FXQ A;  2XS3 A;  3K7N A;  2MLS A;  1UMS A;  2AYK A;  2JT5 A;  4XM8 A;  4GR8 A;  3F1A A;  3LIR A;  5CXA A;  3I7I A;  3AYU A;  3HY7 A;  5D7W A;  1D7X A;  2JT6 A;  1HTD A;  1O0T A;  2MZH A;  3L0T A;  5B5P A;  1EB6 A;  1B3D A;  1JH1 A;  2OW2 A;  2MZI A;  1CGL A;  3DWB A;  1J7N A;  5D2B A;  4IJO A;  1KUG A;  3DPF A;  4DF9 A;  1R55 A;  1XUD A;  4WKI A;  3AIG A;  1IAA A;  1BKC E;  4JPA A;  1G05 A;  2YB9 A;  1ZS0 A;  1K7Q A;  1XFZ A;  5CUH A;  2TCL A;  2OW1 A;  2JIH A;  4DV8 A;  3MA2 A;  1R54 A;  4ZR5 A;  4PKW A;  1OM8 A;  1BSW A;  4G9L A;  1OO9 A;  3O64 A;  4G0D A;  4AUO A;  4GQL A;  1CQR A;  1GE6 A;  3LMC A;  1XFV A;  4GWM A;  3Q2H A;  4H30 A;  2OXZ A;  1C7K A;  2OXW A;  3LQB A;  1ND1 A;  1UTZ A;  1Y8J A;  1A86 A;  4PKT A;  2I47 A;  2X3A A;  1HY7 A;  3O2X A;  1SRP A;  2POJ A;  1ZTQ A;  1PWQ A;  1CGE A;  4H49 A;  3EDG A;  3LQ0 A;  4GUY A;  2WOA A;  2OXU A;  2DDF A;  1QIA A;  3Q2G A;  5D1T A;  2V4B A;  1MMP A;  1MMB A;  1JIW P;  1JAO A;  2MLR A;  4WZV A;  1MMQ A;  1KUF A;  5BOY A;  3OHL A;  1KUK A;  1RM8 A;  3LIK A;  2X3C A;  4H3X A;  4XBH A;  3ZUK A;  1B8Y A;  3B92 A;  4AYK A;  5B5O A;  3G5C A;  1G49 A;  2AIG P;  3P1V A;  2QPJ A;  2RJP A;  4H82 A;  3WV2 A;  3LKA A;  1UMT A;  1XFY A;  2OZR A;  3B8Z A;  1CK7 A;  2XS4 A;  3LUM A;  1A85 A;  1BUD A;  4H76 A;  4QKZ A;  2A8H A;  1BIW A;  2USN A;  1I1I P;  1G9K A;  1PWP A;  2D1O A;  2ERO A;  3OHO A;  1K7I A;  3LK8 A;  5LAB A;  1HFC A;  3USN A;  3LJG A;  4PKS A;  4IUW A;  3CKI A;  3L0V A;  4FVL A;  1G4K A;  2ERQ A;  2O36 A;  5I43 A;  2E3X A;  3HBV P;  3LE9 A;  1SLM A;  3LGP A;  1HOV A;  2OI0 A;  4WF6 A;  3P24 A;  1EUB A;  2W15 A;  4I35 A;  3B2Z A;  1KAP P;  3VTG A;  2DDY A;  1C8T A;  3TSK A;  2K9C A;  1AST A;  4ILW D;  4DPE A;  3TS4 A;  2OVX A;  1G12 A;  1FBL A;  1Y0V A;  2DW0 A;  4ON1 A;  1XUC A;  3HBU P;  1ATL A;  3F17 A;  2W12 A;  4JA1 A;  4CTH A;  1K7G A;  3EDI A;  3ZXH A;  3WV3 A;  1QJJ A;  2DW2 A;  4A3W A;  5L79 A;  2X3B A;  1S4B P;  2Z2D A;  3DPE A;  2Y6D A;  1Y93 A;  3EHX A; 
#chains in the Genus database with same CATH topology
 2OVZ A;  1AKL A;  3U1R A;  5I4O A;  3ELM A;  4PKR A;  4DD8 A;  3NX7 A;  1R1H A;  3KMC A;  4WK7 A;  2D1N A;  4FU4 A;  1USN A;  1I73 A;  3KHI A;  3RTS A;  3K7L A;  5I12 A;  2K2G A;  1O0Q A;  4GF1 A;  1BUV M;  3LEA A;  1GE7 A;  4L19 A;  3LIL A;  3DSL A;  1YP1 A;  3ZVS A;  2YUF A;  1CGF A;  1XFW A;  1FLS A;  1JJ9 A;  3DNG A;  4HX3 A;  5I0L A;  3HY9 A;  4PKU A;  1IAC A;  1GE5 A;  2E2D A;  1JKY A;  966C A;  3DTK A;  1Z3J A;  1IAB A;  4JQG A;  1BM6 A;  3V96 B;  3HDB A;  2OY2 A;  4HMA A;  2SRT A;  1ZVX A;  2X7M A;  1ZXV A;  2PJT A;  3EHY A;  2J83 A;  3F19 A;  2OY4 A;  1WNI A;  4AIG A;  1AF0 A;  1R1J A;  1C3I A;  1XFX A;  1GXD A;  3KRY A;  1YCM A;  4WKE A;  1GO8 P;  2JNP A;  1ROS A;  4H2E A;  2N8R A;  1QIB A;  2W14 A;  4PKQ A;  3G42 A;  3F16 A;  1SAT A;  1EAK A;  1CAQ A;  1L6J A;  3WV1 A;  4Q1L A;  1D8M A;  1KUI A;  5BPA A;  2RJQ A;  2FV9 A;  4GWN A;  2YIG A;  4I03 A;  2HU6 A;  1OM6 A;  1QIC A;  1OMJ A;  4FXY P;  4XM7 A;  2OW9 A;  3EDH A;  1XFU A;  1OS2 A;  1YQY A;  3LJZ A;  4J4M A;  4JP4 A;  1MMR A;  1OM7 A;  2W13 A;  1BKC I;  1KUH A;  3TVC A;  1HV5 A;  4L63 A;  2WO8 A;  2W0D A;  3GBO A;  1IAG A;  1I76 A;  3VI1 A;  1BKC A;  1ZXC A;  3KEK A;  3E8R A;  3KEJ A;  1R1I A;  1JAN A;  4H84 A;  1PWW A;  3KEC A;  2J0T A;  1CIZ A;  1PWU A;  2L0R A;  3HYG A;  1Q3A A;  1SMP A;  3N2V A;  3F15 A;  3LJT A;  1JAQ A;  4XCT A;  1QJI A;  1GO7 P;  1BQQ M;  4A7B A;  1BZS A;  4XM6 A;  1RMZ A;  2ERP A;  2FV5 A;  5CZM A;  4GR0 A;  3SHI A;  3N2U A;  1UEA A;  2WO9 A;  2DW1 A;  4EFS A;  456C A;  3EDZ A;  2MZE A;  1JK3 A;  3TT4 A;  2OW0 A;  1DMT A;  5JMY A;  1D5J A;  3AYK A;  1YOU A;  3KME A;  1MNC A;  3EWJ A;  1AYK A;  1JAP A;  3RTT A;  5D1U A;  1D8F A;  3HDA P;  4IN9 A;  5H8X A;  1JIZ A;  5L7F A;  1SLN A;  1GKC A;  1CXV A;  3HB2 P;  3DL1 A;  1QUA A;  2JSD A;  4AXQ A;  1UTT A;  2CLT A;  5I2Z A;  1GKD A;  1OS9 A;  4GR3 A;  4PKV A;  1BQO A;  1SU3 A;  1PWV A;  830C A;  4JIJ A;  3LUN A;  5D1S A;  5I3M A;  2KRJ A;  4L6T A;  5BOT A;  4R3V A;  1H71 P;  3KWV C;  3BA0 A;  3I7G A;  1IAD A;  2Y6C A;  2CKI A;  2O3E A;  1FM1 A;  4H1Q A;  1ZP5 A;  1XUR A;  3UVC A;  1IAE A;  1HFS A;  3F18 A;  1KBC A;  1DTH A;  5D3C A;  4FXQ A;  2XS3 A;  3K7N A;  2MLS A;  1UMS A;  2AYK A;  2JT5 A;  4XM8 A;  4GR8 A;  3F1A A;  3LIR A;  5CXA A;  3I7I A;  3AYU A;  3HY7 A;  5D7W A;  1D7X A;  1TVI A;  2JT6 A;  1HTD A;  1O0T A;  2MZH A;  3L0T A;  5B5P A;  1EB6 A;  1B3D A;  1JH1 A;  2OW2 A;  2MZI A;  1CGL A;  3DWB A;  1J7N A;  5D2B A;  4IJO A;  1KUG A;  3DPF A;  4DF9 A;  1R55 A;  1XUD A;  4WKI A;  3AIG A;  1IAA A;  1BKC E;  4JPA A;  1G05 A;  2YB9 A;  1ZS0 A;  1K7Q A;  1XFZ A;  5CUH A;  2TCL A;  2OW1 A;  2JIH A;  4DV8 A;  3MA2 A;  1R54 A;  4ZR5 A;  4PKW A;  1OM8 A;  1BSW A;  4G9L A;  1OO9 A;  3O64 A;  4G0D A;  4AUO A;  4GQL A;  1CQR A;  1GE6 A;  3LMC A;  1XFV A;  4GWM A;  3Q2H A;  4H30 A;  2OXZ A;  1C7K A;  2OXW A;  3LQB A;  1ND1 A;  1UTZ A;  1Y8J A;  1A86 A;  4PKT A;  2I47 A;  2X3A A;  1HY7 A;  3O2X A;  1SRP A;  2POJ A;  1ZTQ A;  1PWQ A;  1CGE A;  4H49 A;  3EDG A;  3LQ0 A;  4GUY A;  2WOA A;  2OXU A;  2DDF A;  1QIA A;  3Q2G A;  5D1T A;  2V4B A;  1MMP A;  1MMB A;  1JIW P;  1XAX A;  1JAO A;  1XM5 A;  2MLR A;  4WZV A;  1MMQ A;  1KUF A;  5BOY A;  3OHL A;  1KUK A;  1RM8 A;  3LIK A;  2X3C A;  4H3X A;  4XBH A;  3ZUK A;  1B8Y A;  3B92 A;  4AYK A;  5B5O A;  3G5C A;  1G49 A;  2AIG P;  3P1V A;  2QPJ A;  2RJP A;  4H82 A;  3WV2 A;  3LKA A;  1UMT A;  1XFY A;  2OZR A;  3B8Z A;  1CK7 A;  2XS4 A;  3LUM A;  1A85 A;  1BUD A;  4H76 A;  4QKZ A;  2A8H A;  1BIW A;  2USN A;  1I1I P;  1G9K A;  1PWP A;  2D1O A;  2ERO A;  3OHO A;  1K7I A;  3LK8 A;  5LAB A;  1HFC A;  1OZ9 A;  3USN A;  3LJG A;  4PKS A;  4IUW A;  3CKI A;  3L0V A;  4FVL A;  1G4K A;  2ERQ A;  2O36 A;  5I43 A;  2E3X A;  3HBV P;  3LE9 A;  1SLM A;  3LGP A;  1HOV A;  2OI0 A;  4WF6 A;  3P24 A;  1EUB A;  2W15 A;  4I35 A;  3B2Z A;  1KAP P;  3VTG A;  2DDY A;  1C8T A;  3TSK A;  2K9C A;  1AST A;  3DTE A;  4ILW D;  4DPE A;  3TS4 A;  2OVX A;  1G12 A;  1FBL A;  1Y0V A;  2DW0 A;  4ON1 A;  1XUC A;  3HBU P;  1ATL A;  3F17 A;  2W12 A;  4JA1 A;  4CTH A;  1K7G A;  3EDI A;  3DTI A;  3ZXH A;  3WV3 A;  1QJJ A;  2DW2 A;  4A3W A;  5L79 A;  2X3B A;  1S4B P;  2Z2D A;  3DPE A;  2Y6D A;  1Y93 A;  4L7A A;  3EHX A; 
#chains in the Genus database with same CATH homology
 2OVZ A;  1AKL A;  3U1R A;  5I4O A;  3ELM A;  4PKR A;  4DD8 A;  3NX7 A;  1R1H A;  3KMC A;  4WK7 A;  2D1N A;  4FU4 A;  1USN A;  1I73 A;  3KHI A;  3RTS A;  3K7L A;  5I12 A;  2K2G A;  1O0Q A;  4GF1 A;  1BUV M;  3LEA A;  1GE7 A;  4L19 A;  3LIL A;  3DSL A;  1YP1 A;  3ZVS A;  2YUF A;  1CGF A;  1XFW A;  1FLS A;  1JJ9 A;  3DNG A;  4HX3 A;  5I0L A;  3HY9 A;  4PKU A;  1IAC A;  1GE5 A;  2E2D A;  1JKY A;  966C A;  3DTK A;  1Z3J A;  1IAB A;  4JQG A;  1BM6 A;  3V96 B;  3HDB A;  2OY2 A;  4HMA A;  2SRT A;  1ZVX A;  2X7M A;  1ZXV A;  2PJT A;  3EHY A;  2J83 A;  3F19 A;  2OY4 A;  1WNI A;  4AIG A;  1AF0 A;  1R1J A;  1C3I A;  1XFX A;  1GXD A;  3KRY A;  1YCM A;  4WKE A;  1GO8 P;  2JNP A;  1ROS A;  4H2E A;  2N8R A;  1QIB A;  2W14 A;  4PKQ A;  3G42 A;  3F16 A;  1SAT A;  1EAK A;  1CAQ A;  1L6J A;  3WV1 A;  4Q1L A;  1D8M A;  1KUI A;  5BPA A;  2RJQ A;  2FV9 A;  4GWN A;  2YIG A;  4I03 A;  2HU6 A;  1OM6 A;  1QIC A;  1OMJ A;  4FXY P;  4XM7 A;  2OW9 A;  3EDH A;  1XFU A;  1OS2 A;  1YQY A;  3LJZ A;  4J4M A;  4JP4 A;  1MMR A;  1OM7 A;  2W13 A;  1BKC I;  1KUH A;  3TVC A;  1HV5 A;  4L63 A;  2WO8 A;  2W0D A;  3GBO A;  1IAG A;  1I76 A;  3VI1 A;  1BKC A;  1ZXC A;  3KEK A;  3E8R A;  3KEJ A;  1R1I A;  1JAN A;  4H84 A;  1PWW A;  3KEC A;  2J0T A;  1CIZ A;  1PWU A;  2L0R A;  3HYG A;  1Q3A A;  1SMP A;  3N2V A;  3F15 A;  3LJT A;  1JAQ A;  4XCT A;  1QJI A;  1GO7 P;  1BQQ M;  4A7B A;  1BZS A;  4XM6 A;  1RMZ A;  2ERP A;  2FV5 A;  5CZM A;  4GR0 A;  3SHI A;  3N2U A;  1UEA A;  2WO9 A;  2DW1 A;  4EFS A;  456C A;  3EDZ A;  2MZE A;  1JK3 A;  3TT4 A;  2OW0 A;  1DMT A;  5JMY A;  1D5J A;  3AYK A;  1YOU A;  3KME A;  1MNC A;  3EWJ A;  1AYK A;  1JAP A;  3RTT A;  5D1U A;  1D8F A;  3HDA P;  4IN9 A;  5H8X A;  1JIZ A;  5L7F A;  1SLN A;  1GKC A;  1CXV A;  3HB2 P;  3DL1 A;  1QUA A;  2JSD A;  4AXQ A;  1UTT A;  2CLT A;  5I2Z A;  1GKD A;  1OS9 A;  4GR3 A;  4PKV A;  1BQO A;  1SU3 A;  1PWV A;  830C A;  4JIJ A;  3LUN A;  5D1S A;  5I3M A;  2KRJ A;  4L6T A;  5BOT A;  4R3V A;  1H71 P;  3KWV C;  3BA0 A;  3I7G A;  1IAD A;  2Y6C A;  2CKI A;  2O3E A;  1FM1 A;  4H1Q A;  1ZP5 A;  1XUR A;  3UVC A;  1IAE A;  1HFS A;  3F18 A;  1KBC A;  1DTH A;  5D3C A;  4FXQ A;  2XS3 A;  3K7N A;  2MLS A;  1UMS A;  2AYK A;  2JT5 A;  4XM8 A;  4GR8 A;  3F1A A;  3LIR A;  5CXA A;  3I7I A;  3AYU A;  3HY7 A;  5D7W A;  1D7X A;  2JT6 A;  1HTD A;  1O0T A;  2MZH A;  3L0T A;  5B5P A;  1EB6 A;  1B3D A;  1JH1 A;  2OW2 A;  2MZI A;  1CGL A;  3DWB A;  1J7N A;  5D2B A;  4IJO A;  1KUG A;  3DPF A;  4DF9 A;  1R55 A;  1XUD A;  4WKI A;  3AIG A;  1IAA A;  1BKC E;  4JPA A;  1G05 A;  2YB9 A;  1ZS0 A;  1K7Q A;  1XFZ A;  5CUH A;  2TCL A;  2OW1 A;  2JIH A;  4DV8 A;  3MA2 A;  1R54 A;  4ZR5 A;  4PKW A;  1OM8 A;  1BSW A;  4G9L A;  1OO9 A;  3O64 A;  4G0D A;  4AUO A;  4GQL A;  1CQR A;  1GE6 A;  3LMC A;  1XFV A;  4GWM A;  3Q2H A;  4H30 A;  2OXZ A;  1C7K A;  2OXW A;  3LQB A;  1ND1 A;  1UTZ A;  1Y8J A;  1A86 A;  4PKT A;  2I47 A;  2X3A A;  1HY7 A;  3O2X A;  1SRP A;  2POJ A;  1ZTQ A;  1PWQ A;  1CGE A;  4H49 A;  3EDG A;  3LQ0 A;  4GUY A;  2WOA A;  2OXU A;  2DDF A;  1QIA A;  3Q2G A;  5D1T A;  2V4B A;  1MMP A;  1MMB A;  1JIW P;  1JAO A;  2MLR A;  4WZV A;  1MMQ A;  1KUF A;  5BOY A;  3OHL A;  1KUK A;  1RM8 A;  3LIK A;  2X3C A;  4H3X A;  4XBH A;  3ZUK A;  1B8Y A;  3B92 A;  4AYK A;  5B5O A;  3G5C A;  1G49 A;  2AIG P;  3P1V A;  2QPJ A;  2RJP A;  4H82 A;  3WV2 A;  3LKA A;  1UMT A;  1XFY A;  2OZR A;  3B8Z A;  1CK7 A;  2XS4 A;  3LUM A;  1A85 A;  1BUD A;  4H76 A;  4QKZ A;  2A8H A;  1BIW A;  2USN A;  1I1I P;  1G9K A;  1PWP A;  2D1O A;  2ERO A;  3OHO A;  1K7I A;  3LK8 A;  5LAB A;  1HFC A;  3USN A;  3LJG A;  4PKS A;  4IUW A;  3CKI A;  3L0V A;  4FVL A;  1G4K A;  2ERQ A;  2O36 A;  5I43 A;  2E3X A;  3HBV P;  3LE9 A;  1SLM A;  3LGP A;  1HOV A;  2OI0 A;  4WF6 A;  3P24 A;  1EUB A;  2W15 A;  4I35 A;  3B2Z A;  1KAP P;  3VTG A;  2DDY A;  1C8T A;  3TSK A;  2K9C A;  1AST A;  3DTE A;  4ILW D;  4DPE A;  3TS4 A;  2OVX A;  1G12 A;  1FBL A;  1Y0V A;  2DW0 A;  4ON1 A;  1XUC A;  3HBU P;  1ATL A;  3F17 A;  2W12 A;  4JA1 A;  4CTH A;  1K7G A;  3EDI A;  3DTI A;  3ZXH A;  3WV3 A;  1QJJ A;  2DW2 A;  4A3W A;  5L79 A;  2X3B A;  1S4B P;  2Z2D A;  3DPE A;  2Y6D A;  1Y93 A;  4L7A A;  3EHX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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