3EDZA

Crystal structure of catalytic domain of tace with hydroxamate inhibitor
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
258
structure length
258
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords ADAM 17
total genus 80
structure length 258
sequence length 258
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2008-09-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3edzA00
2XS4A 4L19A 5I0LA 3LUMA 3F18A 3I7IA 1ASTA 3MA2A 5D3CA 1G9KA 4QKZA 1UEAA 5JMYA 1SATA 1ZTQA 4R3VA 1XFYA 2W14A 3P24A 1CGFA 3HDAP 1G12A 3EHXA 1EB6A 3AYKA 2PJTA 4JPAA 3EDIA 5BOYA 1PWUA 2JT6A 4PKUA 3RTSA 2MZHA 3F1AA 1UTTA 3RTTA 4XM6A 2USNA 1FM1A 1XFUA 2MZIA 3N2VA 1MMQA 4HX3A 3O64A 3CKIA 2ERQA 2OW2A 3V96B 3WV2A 1HOVA 3F19A 1KUKA 1IAAA 1CXVA 1SLNA 3KMCA 3O2XA 1G49A 1CQRA 1OS9A 1ND1A 5D7WA 4A3WA 4WF6A 5BPAA 1IADA 2DDFA 4Q1LA 1RMZA 2N8RA 1JAOA 2I47A 1G4KA 4DV8A 1OM7A 4DPEA 1H71P 3KECA 3ELMA 5I2ZA 3DPEA 1JIZA 1BQQM 1MMRA 4JP4A 1JK3A 2WO9A 4PKQA 1EAKA 5I4OA 1SU3A 4GUYA 2V4BA 5I12A 4FXQA 3UVCA 2OY2A 4JQGA 1GO8P 1L6JA 1CGLA 1BUVM 1QUAA 4XM7A 3Q2GA 2JT5A 2K9CA 1Y93A 4FVLA 1UTZA 2QPJA 3DL1A 1BKCI 1CIZA 3EDGA 1ZXVA 3L0VA 1C3IA 2W0DA 4HMAA 3TS4A 4GR8A 1R54A 3N2UA 5I43A 3Q2HA 1QJJA 4IJOA 5B5PA 5L7FA 4I03A 1DMTA 3LGPA 1AKLA 3LE9A 3LQ0A 3U1RA 5D2BA 1Z3JA 2X7MA 1D8MA 4WKEA 1S4BP 1QIBA 2TCLA 4H76A 1G05A 1YQYA 2POJA 2W13A 1SRPA 3G5CA 3KEJA 3G42A 3HY7A 2DW1A 2D1OA 5D1UA 1KBCA 1CGEA 1GE5A 3LILA 4H49A 1BKCA 1BSWA 3DSLA 4J4MA 2FV5A 2OVZA 3GBOA 1OO9A 1D8FA 4AYKA 1JAPA 1FLSA 4ZR5A 1C8TA 2OVXA 2OXZA 3LQBA 4G9LA 3HYGA 2CLTA 2MLSA 3F15A 1Q3AA 4IN9A 1USNA 1XUDA 3TSKA 2E3XA 1K7GA 1PWWA 1OM8A 2X3CA 1D7XA 1GKDA 2WOAA 3LJGA 3DNGA 3KHIA 4XM8A 1FBLA 4XBHA 2OW9A 1RM8A 1O0TA 1JANA 1KUHA 3WV1A 2OY4A 2EROA 3HY9A 3OHOA 2O36A 4ILWD 4PKWA 2SRTA 3F17A 1C7KA 4AXQA 3DPFA 4G0DA 3DWBA 1CK7A 1BUDA 1JH1A 2DDYA 2KRJA 4XCTA 5LABA 1JIWP 2OW0A 1R55A 1R1JA 4JA1A 3HB2P 2DW0A 1ATLA 3LK8A 4GR3A 1GO7P 4WKIA 2D1NA 1I1IP 1K7QA 2X3BA 1MNCA 1BQOA 1XFWA 1EUBA 4GWMA 3L0TA 2OW1A 2ERPA 1B8YA 3AIGA 3B8ZA 1A86A 5CZMA 2MZEA 4FXYP 2WO8A 3BA0A 1MMPA 1ZP5A 1SLMA 5BOTA 1ROSA 1IACA 4I35A 1YCMA 3VTGA 4EFSA 3LJZA 4FU4A 3TT4A 4H30A 1YP1A 2AIGP 3LIKA 3LMCA 2Y6DA 1IABA 1PWPA 3KWVC 1R1HA 3VI1A 4AUOA 4PKRA 3EHYA 1I73A 1CAQA 4GWNA 3F16A 3AYUA 1KUGA 3LUNA 2J0TA 3KRYA 3LJTA 4GQLA 2O3EA 2X3AA 2DW2A 4PKTA 2E2DA 3TVCA 3USNA 3I7GA 966CA 1Y8JA 4H82A 2JSDA 2J83A 4AIGA 1BM6A 1K7IA 1Y0VA 3HDBA 2A8HA 1OMJA 1OM6A 3HBUP 830CA 1SMPA 2K2GA 2FV9A 1XFZA 1JJ9A 3LEAA 1GKCA 1I76A 1KUIA 5L79A 1QICA 1AF0A 4L63A 4H2EA 1UMSA 2HU6A 1HY7A 2YIGA 2Y6CA 2W12A 1QJIA 4L6TA 1ZXCA 3ZXHA 5D1TA 3B2ZA 4H3XA 1O0QA 5CXAA 2RJQA 4GR0A 2Z2DA 1BKCE 1IAGA 3EWJA 5B5OA 1GE7A 2W15A 3K7NA 1UMTA 4GF1A 2AYKA 4H1QA 3WV3A 1IAEA 3E8RA 1XFXA 1ZS0A 1XFVA 3ZUKA 2YB9A 5I3MA 1GE6A 3KEKA 5CUHA 3SHIA 4WK7A 2OI0A 4PKSA 1OS2A 2JIHA 1PWVA 1J7NA 3EDZA 4JIJA 3B92A 2OXWA 3OHLA 1KUFA 1KAPP 2JNPA 1ZVXA 1BZSA 1XUCA 3KMEA 4ON1A 1HV5A 1HFSA 1A85A 1R1IA 2RJPA 2CKIA 3LIRA 2OZRA 1HFCA 4DF9A 4CTHA 2L0RA 1BIWA 3HBVP 4WZVA 2XS3A 3P1VA 5D1SA 1B3DA 1DTHA 4PKVA 4DD8A 1WNIA 5H8XA 3LKAA 4IUWA 456CA 1AYKA 2MLRA 1PWQA 1JKYA 1YOUA 1D5JA 4A7BA 2OXUA 1XURA 1QIAA 1MMBA 4H84A 1HTDA 3EDHA 1JAQA 1GXDA 3K7LA 3ZVSA 3NX7A
chains in the Genus database with same CATH superfamily
2XS4A 4L19A 5I0LA 3LUMA 3F18A 3I7IA 1ASTA 3MA2A 5D3CA 1G9KA 4QKZA 1UEAA 5JMYA 1SATA 1ZTQA 4R3VA 1XFYA 2W14A 3P24A 3DTEA 1CGFA 3HDAP 1G12A 3EHXA 1EB6A 3AYKA 2PJTA 4JPAA 3EDIA 5BOYA 1PWUA 2JT6A 4PKUA 3RTSA 2MZHA 3F1AA 1UTTA 3RTTA 4XM6A 2USNA 1FM1A 1XFUA 2MZIA 3N2VA 1MMQA 4HX3A 3O64A 3CKIA 2ERQA 2OW2A 3V96B 3WV2A 1HOVA 3F19A 1KUKA 1IAAA 1CXVA 1SLNA 3KMCA 3O2XA 1G49A 1CQRA 1OS9A 1ND1A 5D7WA 4A3WA 4WF6A 5BPAA 1IADA 2DDFA 4Q1LA 1RMZA 2N8RA 1JAOA 2I47A 1G4KA 4DV8A 1OM7A 4DPEA 1H71P 3KECA 3ELMA 5I2ZA 3DPEA 1JIZA 1BQQM 1MMRA 4JP4A 1JK3A 2WO9A 4PKQA 1EAKA 5I4OA 1SU3A 4GUYA 2V4BA 2YUFA 5I12A 4FXQA 3UVCA 2OY2A 4JQGA 1GO8P 1L6JA 1CGLA 1BUVM 1QUAA 4XM7A 3Q2GA 2JT5A 2K9CA 1Y93A 4FVLA 1UTZA 2QPJA 3DL1A 1BKCI 1CIZA 3EDGA 1ZXVA 3L0VA 1C3IA 2W0DA 4HMAA 3TS4A 4GR8A 1R54A 3N2UA 5I43A 3Q2HA 1QJJA 4IJOA 5B5PA 5L7FA 4I03A 1DMTA 3LGPA 3DTIA 1AKLA 3LE9A 3LQ0A 3U1RA 5D2BA 1Z3JA 2X7MA 1D8MA 4WKEA 1S4BP 1QIBA 2TCLA 4H76A 1G05A 1YQYA 2POJA 2W13A 1SRPA 3G5CA 3KEJA 3G42A 3HY7A 2DW1A 2D1OA 5D1UA 1KBCA 1CGEA 1GE5A 3LILA 4H49A 1BKCA 1BSWA 3DSLA 4J4MA 2FV5A 2OVZA 3GBOA 1OO9A 1D8FA 4AYKA 1JAPA 1FLSA 4ZR5A 1C8TA 3DTKA 2OVXA 2OXZA 3LQBA 4G9LA 3HYGA 2CLTA 2MLSA 3F15A 1Q3AA 4IN9A 1USNA 1XUDA 3TSKA 1OZ9A 2E3XA 1K7GA 1PWWA 1OM8A 2X3CA 1D7XA 1GKDA 2WOAA 3LJGA 3DNGA 3KHIA 4XM8A 1FBLA 4XBHA 2OW9A 1RM8A 1O0TA 1JANA 1KUHA 3WV1A 2OY4A 2EROA 3HY9A 3OHOA 2O36A 4ILWD 4PKWA 2SRTA 3F17A 1C7KA 4AXQA 3DPFA 4G0DA 3DWBA 1CK7A 1BUDA 1JH1A 2DDYA 2KRJA 4XCTA 5LABA 1JIWP 2OW0A 1R55A 1R1JA 4JA1A 3HB2P 2DW0A 1ATLA 3LK8A 4GR3A 1GO7P 4WKIA 2D1NA 1I1IP 1K7QA 2X3BA 1MNCA 1BQOA 1XFWA 1EUBA 4GWMA 3L0TA 2OW1A 2ERPA 1B8YA 3AIGA 3B8ZA 1A86A 1TVIA 5CZMA 2MZEA 4FXYP 2WO8A 3BA0A 1MMPA 1ZP5A 1SLMA 5BOTA 1ROSA 1IACA 4I35A 1YCMA 3VTGA 4EFSA 3LJZA 4FU4A 3TT4A 4H30A 1YP1A 2AIGP 3LIKA 3LMCA 2Y6DA 1IABA 1PWPA 3KWVC 1R1HA 3VI1A 4AUOA 4PKRA 3EHYA 1I73A 1CAQA 4GWNA 3F16A 3AYUA 1XAXA 1KUGA 3LUNA 2J0TA 3KRYA 3LJTA 4GQLA 2O3EA 2X3AA 2DW2A 4PKTA 2E2DA 3TVCA 3USNA 3I7GA 966CA 1Y8JA 4H82A 2JSDA 2J83A 4AIGA 1BM6A 1K7IA 1Y0VA 3HDBA 2A8HA 1OMJA 1OM6A 3HBUP 830CA 1SMPA 2K2GA 2FV9A 1XFZA 1JJ9A 3LEAA 1GKCA 1I76A 1KUIA 5L79A 1QICA 1AF0A 4L63A 4H2EA 1UMSA 2HU6A 1HY7A 2YIGA 2Y6CA 2W12A 1QJIA 4L6TA 1ZXCA 3ZXHA 5D1TA 3B2ZA 4H3XA 1O0QA 5CXAA 2RJQA 4GR0A 2Z2DA 1BKCE 1IAGA 3EWJA 5B5OA 1GE7A 2W15A 3K7NA 1UMTA 4GF1A 2AYKA 4H1QA 3WV3A 1IAEA 3E8RA 1XFXA 1ZS0A 1XFVA 3ZUKA 2YB9A 5I3MA 3KEKA 1GE6A 5CUHA 3SHIA 4WK7A 2OI0A 4PKSA 1OS2A 2JIHA 1PWVA 1J7NA 3EDZA 4JIJA 3B92A 2OXWA 3OHLA 1KUFA 1KAPP 2JNPA 1ZVXA 1BZSA 1XUCA 3KMEA 4ON1A 1HV5A 1HFSA 1A85A 1R1IA 2RJPA 2CKIA 3LIRA 2OZRA 1HFCA 4DF9A 4CTHA 2L0RA 1BIWA 3HBVP 4WZVA 2XS3A 3P1VA 5D1SA 1B3DA 1DTHA 4PKVA 1XM5A 4DD8A 1WNIA 5H8XA 3LKAA 4IUWA 456CA 1AYKA 2MLRA 1PWQA 4L7AA 1JKYA 1YOUA 1D5JA 4A7BA 2OXUA 1XURA 1QIAA 1MMBA 4H84A 1HTDA 3EDHA 1JAQA 1GXDA 3K7LA 3ZVSA 3NX7A
chains in the Genus database with same CATH topology
2XS4A 4L19A 5I0LA 3LUMA 3F18A 3I7IA 1ASTA 3MA2A 5D3CA 1G9KA 4QKZA 1UEAA 5JMYA 1SATA 1ZTQA 4R3VA 1XFYA 2W14A 3P24A 3DTEA 1CGFA 3HDAP 1G12A 3EHXA 1EB6A 3AYKA 2PJTA 4JPAA 3EDIA 5BOYA 1PWUA 2JT6A 4PKUA 3RTSA 2MZHA 3F1AA 1UTTA 3RTTA 4XM6A 2USNA 1FM1A 1XFUA 2MZIA 3N2VA 1MMQA 4HX3A 3O64A 3CKIA 2ERQA 2OW2A 3V96B 3WV2A 1HOVA 3F19A 1KUKA 1IAAA 1CXVA 1SLNA 3KMCA 3O2XA 1G49A 1CQRA 1OS9A 1ND1A 5D7WA 4A3WA 4WF6A 5BPAA 1IADA 2DDFA 4Q1LA 1RMZA 2N8RA 1JAOA 2I47A 1G4KA 4DV8A 1OM7A 4DPEA 1H71P 3KECA 3ELMA 5I2ZA 3DPEA 1JIZA 1BQQM 1MMRA 4JP4A 1JK3A 2WO9A 4PKQA 1EAKA 5I4OA 1SU3A 4GUYA 2V4BA 2YUFA 5I12A 4FXQA 3UVCA 2OY2A 4JQGA 1GO8P 1L6JA 1CGLA 1BUVM 1QUAA 4XM7A 3Q2GA 2JT5A 2K9CA 1Y93A 4FVLA 1UTZA 2QPJA 3DL1A 1BKCI 1CIZA 3EDGA 1ZXVA 3L0VA 1C3IA 2W0DA 4HMAA 3TS4A 4GR8A 1R54A 3N2UA 5I43A 3Q2HA 1QJJA 4IJOA 5B5PA 5L7FA 4I03A 1DMTA 3LGPA 3DTIA 1AKLA 3LE9A 3LQ0A 3U1RA 5D2BA 1Z3JA 2X7MA 1D8MA 4WKEA 1S4BP 1QIBA 2TCLA 4H76A 1G05A 1YQYA 2POJA 2W13A 1SRPA 3G5CA 3KEJA 3G42A 3HY7A 2DW1A 2D1OA 5D1UA 1KBCA 1CGEA 1GE5A 3LILA 4H49A 1BKCA 1BSWA 3DSLA 4J4MA 2FV5A 2OVZA 3GBOA 1OO9A 1D8FA 4AYKA 1JAPA 1FLSA 4ZR5A 1C8TA 3DTKA 2OVXA 2OXZA 3LQBA 4G9LA 3HYGA 2CLTA 2MLSA 3F15A 1Q3AA 4IN9A 1USNA 1XUDA 3TSKA 2E3XA 1K7GA 1PWWA 1OM8A 2X3CA 1D7XA 1GKDA 2WOAA 3LJGA 3DNGA 3KHIA 4XM8A 1FBLA 4XBHA 2OW9A 1RM8A 1O0TA 1JANA 1KUHA 3WV1A 2OY4A 2EROA 3HY9A 3OHOA 2O36A 4ILWD 4PKWA 2SRTA 3F17A 1C7KA 4AXQA 3DPFA 4G0DA 3DWBA 1CK7A 1BUDA 1JH1A 2DDYA 2KRJA 4XCTA 5LABA 1JIWP 2OW0A 1R55A 1R1JA 4JA1A 3HB2P 2DW0A 1ATLA 3LK8A 4GR3A 1GO7P 4WKIA 2D1NA 1I1IP 1K7QA 2X3BA 1MNCA 1BQOA 1XFWA 1EUBA 4GWMA 3L0TA 2OW1A 2ERPA 1B8YA 3AIGA 3B8ZA 1A86A 5CZMA 2MZEA 4FXYP 2WO8A 3BA0A 1MMPA 1ZP5A 1SLMA 5BOTA 1ROSA 1IACA 4I35A 1YCMA 3VTGA 4EFSA 3LJZA 4FU4A 3TT4A 4H30A 1YP1A 2AIGP 3LIKA 3LMCA 2Y6DA 1IABA 1PWPA 3KWVC 1R1HA 3VI1A 4AUOA 4PKRA 3EHYA 1I73A 1CAQA 4GWNA 3F16A 3AYUA 1KUGA 3LUNA 2J0TA 3KRYA 3LJTA 4GQLA 2O3EA 2X3AA 2DW2A 4PKTA 2E2DA 3TVCA 3USNA 3I7GA 966CA 1Y8JA 4H82A 2JSDA 2J83A 4AIGA 1BM6A 1K7IA 1Y0VA 3HDBA 2A8HA 1OMJA 1OM6A 3HBUP 830CA 1SMPA 2K2GA 2FV9A 1XFZA 1JJ9A 3LEAA 1GKCA 1I76A 1KUIA 5L79A 1QICA 1AF0A 4L63A 4H2EA 1UMSA 2HU6A 1HY7A 2YIGA 2Y6CA 2W12A 1QJIA 4L6TA 1ZXCA 3ZXHA 5D1TA 3B2ZA 4H3XA 1O0QA 5CXAA 2RJQA 4GR0A 2Z2DA 1BKCE 1IAGA 3EWJA 5B5OA 1GE7A 2W15A 3K7NA 1UMTA 4GF1A 2AYKA 4H1QA 3WV3A 1IAEA 3E8RA 1XFXA 1ZS0A 1XFVA 3ZUKA 2YB9A 5I3MA 1GE6A 3KEKA 5CUHA 3SHIA 4WK7A 2OI0A 4PKSA 1OS2A 2JIHA 1PWVA 1J7NA 3EDZA 4JIJA 3B92A 2OXWA 3OHLA 1KUFA 1KAPP 2JNPA 1ZVXA 1BZSA 1XUCA 3KMEA 4ON1A 1HV5A 1HFSA 1A85A 1R1IA 2RJPA 2CKIA 3LIRA 2OZRA 1HFCA 4DF9A 4CTHA 2L0RA 1BIWA 3HBVP 4WZVA 2XS3A 3P1VA 5D1SA 1B3DA 1DTHA 4PKVA 4DD8A 1WNIA 5H8XA 3LKAA 4IUWA 456CA 1AYKA 2MLRA 1PWQA 4L7AA 1JKYA 1YOUA 1D5JA 4A7BA 2OXUA 1XURA 1QIAA 1MMBA 4H84A 1HTDA 3EDHA 1JAQA 1GXDA 3K7LA 3ZVSA 3NX7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XS4 A;  4L19 A;  5I0L A;  3LUM A;  3F18 A;  3I7I A;  1AST A;  3MA2 A;  5D3C A;  1G9K A;  4QKZ A;  1UEA A;  5JMY A;  1SAT A;  1ZTQ A;  4R3V A;  1XFY A;  2W14 A;  3P24 A;  1CGF A;  3HDA P;  1G12 A;  3EHX A;  1EB6 A;  3AYK A;  2PJT A;  4JPA A;  3EDI A;  5BOY A;  1PWU A;  2JT6 A;  4PKU A;  3RTS A;  2MZH A;  3F1A A;  1UTT A;  3RTT A;  4XM6 A;  2USN A;  1FM1 A;  1XFU A;  2MZI A;  3N2V A;  1MMQ A;  4HX3 A;  3O64 A;  3CKI A;  2ERQ A;  2OW2 A;  3V96 B;  3WV2 A;  1HOV A;  3F19 A;  1KUK A;  1IAA A;  1CXV A;  1SLN A;  3KMC A;  3O2X A;  1G49 A;  1CQR A;  1OS9 A;  1ND1 A;  5D7W A;  4A3W A;  4WF6 A;  5BPA A;  1IAD A;  2DDF A;  4Q1L A;  1RMZ A;  2N8R A;  1JAO A;  2I47 A;  1G4K A;  4DV8 A;  1OM7 A;  4DPE A;  1H71 P;  3KEC A;  3ELM A;  5I2Z A;  3DPE A;  1JIZ A;  1BQQ M;  1MMR A;  4JP4 A;  1JK3 A;  2WO9 A;  4PKQ A;  1EAK A;  5I4O A;  1SU3 A;  4GUY A;  2V4B A;  5I12 A;  4FXQ A;  3UVC A;  2OY2 A;  4JQG A;  1GO8 P;  1L6J A;  1CGL A;  1BUV M;  1QUA A;  4XM7 A;  3Q2G A;  2JT5 A;  2K9C A;  1Y93 A;  4FVL A;  1UTZ A;  2QPJ A;  3DL1 A;  1BKC I;  1CIZ A;  3EDG A;  1ZXV A;  3L0V A;  1C3I A;  2W0D A;  4HMA A;  3TS4 A;  4GR8 A;  1R54 A;  3N2U A;  5I43 A;  3Q2H A;  1QJJ A;  4IJO A;  5B5P A;  5L7F A;  4I03 A;  1DMT A;  3LGP A;  1AKL A;  3LE9 A;  3LQ0 A;  3U1R A;  5D2B A;  1Z3J A;  2X7M A;  1D8M A;  4WKE A;  1S4B P;  1QIB A;  2TCL A;  4H76 A;  1G05 A;  1YQY A;  2POJ A;  2W13 A;  1SRP A;  3G5C A;  3KEJ A;  3G42 A;  3HY7 A;  2DW1 A;  2D1O A;  5D1U A;  1KBC A;  1CGE A;  1GE5 A;  3LIL A;  4H49 A;  1BKC A;  1BSW A;  3DSL A;  4J4M A;  2FV5 A;  2OVZ A;  3GBO A;  1OO9 A;  1D8F A;  4AYK A;  1JAP A;  1FLS A;  4ZR5 A;  1C8T A;  2OVX A;  2OXZ A;  3LQB A;  4G9L A;  3HYG A;  2CLT A;  2MLS A;  3F15 A;  1Q3A A;  4IN9 A;  1USN A;  1XUD A;  3TSK A;  2E3X A;  1K7G A;  1PWW A;  1OM8 A;  2X3C A;  1D7X A;  1GKD A;  2WOA A;  3LJG A;  3DNG A;  3KHI A;  4XM8 A;  1FBL A;  4XBH A;  2OW9 A;  1RM8 A;  1O0T A;  1JAN A;  1KUH A;  3WV1 A;  2OY4 A;  2ERO A;  3HY9 A;  3OHO A;  2O36 A;  4ILW D;  4PKW A;  2SRT A;  3F17 A;  1C7K A;  4AXQ A;  3DPF A;  4G0D A;  3DWB A;  1CK7 A;  1BUD A;  1JH1 A;  2DDY A;  2KRJ A;  4XCT A;  5LAB A;  1JIW P;  2OW0 A;  1R55 A;  1R1J A;  4JA1 A;  3HB2 P;  2DW0 A;  1ATL A;  3LK8 A;  4GR3 A;  1GO7 P;  4WKI A;  2D1N A;  1I1I P;  1K7Q A;  2X3B A;  1MNC A;  1BQO A;  1XFW A;  1EUB A;  4GWM A;  3L0T A;  2OW1 A;  2ERP A;  1B8Y A;  3AIG A;  3B8Z A;  1A86 A;  5CZM A;  2MZE A;  4FXY P;  2WO8 A;  3BA0 A;  1MMP A;  1ZP5 A;  1SLM A;  5BOT A;  1ROS A;  1IAC A;  4I35 A;  1YCM A;  3VTG A;  4EFS A;  3LJZ A;  4FU4 A;  3TT4 A;  4H30 A;  1YP1 A;  2AIG P;  3LIK A;  3LMC A;  2Y6D A;  1IAB A;  1PWP A;  3KWV C;  1R1H A;  3VI1 A;  4AUO A;  4PKR A;  3EHY A;  1I73 A;  1CAQ A;  4GWN A;  3F16 A;  3AYU A;  1KUG A;  3LUN A;  2J0T A;  3KRY A;  3LJT A;  4GQL A;  2O3E A;  2X3A A;  2DW2 A;  4PKT A;  2E2D A;  3TVC A;  3USN A;  3I7G A;  966C A;  1Y8J A;  4H82 A;  2JSD A;  2J83 A;  4AIG A;  1BM6 A;  1K7I A;  1Y0V A;  3HDB A;  2A8H A;  1OMJ A;  1OM6 A;  3HBU P;  830C A;  1SMP A;  2K2G A;  2FV9 A;  1XFZ A;  1JJ9 A;  3LEA A;  1GKC A;  1I76 A;  1KUI A;  5L79 A;  1QIC A;  1AF0 A;  4L63 A;  4H2E A;  1UMS A;  2HU6 A;  1HY7 A;  2YIG A;  2Y6C A;  2W12 A;  1QJI A;  4L6T A;  1ZXC A;  3ZXH A;  5D1T A;  3B2Z A;  4H3X A;  1O0Q A;  5CXA A;  2RJQ A;  4GR0 A;  2Z2D A;  1BKC E;  1IAG A;  3EWJ A;  5B5O A;  1GE7 A;  2W15 A;  3K7N A;  1UMT A;  4GF1 A;  2AYK A;  4H1Q A;  3WV3 A;  1IAE A;  3E8R A;  1XFX A;  1ZS0 A;  1XFV A;  3ZUK A;  2YB9 A;  5I3M A;  1GE6 A;  3KEK A;  5CUH A;  3SHI A;  4WK7 A;  2OI0 A;  4PKS A;  1OS2 A;  2JIH A;  1PWV A;  1J7N A;  3EDZ A;  4JIJ A;  3B92 A;  2OXW A;  3OHL A;  1KUF A;  1KAP P;  2JNP A;  1ZVX A;  1BZS A;  1XUC A;  3KME A;  4ON1 A;  1HV5 A;  1HFS A;  1A85 A;  1R1I A;  2RJP A;  2CKI A;  3LIR A;  2OZR A;  1HFC A;  4DF9 A;  4CTH A;  2L0R A;  1BIW A;  3HBV P;  4WZV A;  2XS3 A;  3P1V A;  5D1S A;  1B3D A;  1DTH A;  4PKV A;  4DD8 A;  1WNI A;  5H8X A;  3LKA A;  4IUW A;  456C A;  1AYK A;  2MLR A;  1PWQ A;  1JKY A;  1YOU A;  1D5J A;  4A7B A;  2OXU A;  1XUR A;  1QIA A;  1MMB A;  4H84 A;  1HTD A;  3EDH A;  1JAQ A;  1GXD A;  3K7L A;  3ZVS A;  3NX7 A; 
#chains in the Genus database with same CATH topology
 2XS4 A;  4L19 A;  5I0L A;  3LUM A;  3F18 A;  3I7I A;  1AST A;  3MA2 A;  5D3C A;  1G9K A;  4QKZ A;  1UEA A;  5JMY A;  1SAT A;  1ZTQ A;  4R3V A;  1XFY A;  2W14 A;  3P24 A;  3DTE A;  1CGF A;  3HDA P;  1G12 A;  3EHX A;  1EB6 A;  3AYK A;  2PJT A;  4JPA A;  3EDI A;  5BOY A;  1PWU A;  2JT6 A;  4PKU A;  3RTS A;  2MZH A;  3F1A A;  1UTT A;  3RTT A;  4XM6 A;  2USN A;  1FM1 A;  1XFU A;  2MZI A;  3N2V A;  1MMQ A;  4HX3 A;  3O64 A;  3CKI A;  2ERQ A;  2OW2 A;  3V96 B;  3WV2 A;  1HOV A;  3F19 A;  1KUK A;  1IAA A;  1CXV A;  1SLN A;  3KMC A;  3O2X A;  1G49 A;  1CQR A;  1OS9 A;  1ND1 A;  5D7W A;  4A3W A;  4WF6 A;  5BPA A;  1IAD A;  2DDF A;  4Q1L A;  1RMZ A;  2N8R A;  1JAO A;  2I47 A;  1G4K A;  4DV8 A;  1OM7 A;  4DPE A;  1H71 P;  3KEC A;  3ELM A;  5I2Z A;  3DPE A;  1JIZ A;  1BQQ M;  1MMR A;  4JP4 A;  1JK3 A;  2WO9 A;  4PKQ A;  1EAK A;  5I4O A;  1SU3 A;  4GUY A;  2V4B A;  2YUF A;  5I12 A;  4FXQ A;  3UVC A;  2OY2 A;  4JQG A;  1GO8 P;  1L6J A;  1CGL A;  1BUV M;  1QUA A;  4XM7 A;  3Q2G A;  2JT5 A;  2K9C A;  1Y93 A;  4FVL A;  1UTZ A;  2QPJ A;  3DL1 A;  1BKC I;  1CIZ A;  3EDG A;  1ZXV A;  3L0V A;  1C3I A;  2W0D A;  4HMA A;  3TS4 A;  4GR8 A;  1R54 A;  3N2U A;  5I43 A;  3Q2H A;  1QJJ A;  4IJO A;  5B5P A;  5L7F A;  4I03 A;  1DMT A;  3LGP A;  3DTI A;  1AKL A;  3LE9 A;  3LQ0 A;  3U1R A;  5D2B A;  1Z3J A;  2X7M A;  1D8M A;  4WKE A;  1S4B P;  1QIB A;  2TCL A;  4H76 A;  1G05 A;  1YQY A;  2POJ A;  2W13 A;  1SRP A;  3G5C A;  3KEJ A;  3G42 A;  3HY7 A;  2DW1 A;  2D1O A;  5D1U A;  1KBC A;  1CGE A;  1GE5 A;  3LIL A;  4H49 A;  1BKC A;  1BSW A;  3DSL A;  4J4M A;  2FV5 A;  2OVZ A;  3GBO A;  1OO9 A;  1D8F A;  4AYK A;  1JAP A;  1FLS A;  4ZR5 A;  1C8T A;  3DTK A;  2OVX A;  2OXZ A;  3LQB A;  4G9L A;  3HYG A;  2CLT A;  2MLS A;  3F15 A;  1Q3A A;  4IN9 A;  1USN A;  1XUD A;  3TSK A;  1OZ9 A;  2E3X A;  1K7G A;  1PWW A;  1OM8 A;  2X3C A;  1D7X A;  1GKD A;  2WOA A;  3LJG A;  3DNG A;  3KHI A;  4XM8 A;  1FBL A;  4XBH A;  2OW9 A;  1RM8 A;  1O0T A;  1JAN A;  1KUH A;  3WV1 A;  2OY4 A;  2ERO A;  3HY9 A;  3OHO A;  2O36 A;  4ILW D;  4PKW A;  2SRT A;  3F17 A;  1C7K A;  4AXQ A;  3DPF A;  4G0D A;  3DWB A;  1CK7 A;  1BUD A;  1JH1 A;  2DDY A;  2KRJ A;  4XCT A;  5LAB A;  1JIW P;  2OW0 A;  1R55 A;  1R1J A;  4JA1 A;  3HB2 P;  2DW0 A;  1ATL A;  3LK8 A;  4GR3 A;  1GO7 P;  4WKI A;  2D1N A;  1I1I P;  1K7Q A;  2X3B A;  1MNC A;  1BQO A;  1XFW A;  1EUB A;  4GWM A;  3L0T A;  2OW1 A;  2ERP A;  1B8Y A;  3AIG A;  3B8Z A;  1A86 A;  1TVI A;  5CZM A;  2MZE A;  4FXY P;  2WO8 A;  3BA0 A;  1MMP A;  1ZP5 A;  1SLM A;  5BOT A;  1ROS A;  1IAC A;  4I35 A;  1YCM A;  3VTG A;  4EFS A;  3LJZ A;  4FU4 A;  3TT4 A;  4H30 A;  1YP1 A;  2AIG P;  3LIK A;  3LMC A;  2Y6D A;  1IAB A;  1PWP A;  3KWV C;  1R1H A;  3VI1 A;  4AUO A;  4PKR A;  3EHY A;  1I73 A;  1CAQ A;  4GWN A;  3F16 A;  3AYU A;  1XAX A;  1KUG A;  3LUN A;  2J0T A;  3KRY A;  3LJT A;  4GQL A;  2O3E A;  2X3A A;  2DW2 A;  4PKT A;  2E2D A;  3TVC A;  3USN A;  3I7G A;  966C A;  1Y8J A;  4H82 A;  2JSD A;  2J83 A;  4AIG A;  1BM6 A;  1K7I A;  1Y0V A;  3HDB A;  2A8H A;  1OMJ A;  1OM6 A;  3HBU P;  830C A;  1SMP A;  2K2G A;  2FV9 A;  1XFZ A;  1JJ9 A;  3LEA A;  1GKC A;  1I76 A;  1KUI A;  5L79 A;  1QIC A;  1AF0 A;  4L63 A;  4H2E A;  1UMS A;  2HU6 A;  1HY7 A;  2YIG A;  2Y6C A;  2W12 A;  1QJI A;  4L6T A;  1ZXC A;  3ZXH A;  5D1T A;  3B2Z A;  4H3X A;  1O0Q A;  5CXA A;  2RJQ A;  4GR0 A;  2Z2D A;  1BKC E;  1IAG A;  3EWJ A;  5B5O A;  1GE7 A;  2W15 A;  3K7N A;  1UMT A;  4GF1 A;  2AYK A;  4H1Q A;  3WV3 A;  1IAE A;  3E8R A;  1XFX A;  1ZS0 A;  1XFV A;  3ZUK A;  2YB9 A;  5I3M A;  3KEK A;  1GE6 A;  5CUH A;  3SHI A;  4WK7 A;  2OI0 A;  4PKS A;  1OS2 A;  2JIH A;  1PWV A;  1J7N A;  3EDZ A;  4JIJ A;  3B92 A;  2OXW A;  3OHL A;  1KUF A;  1KAP P;  2JNP A;  1ZVX A;  1BZS A;  1XUC A;  3KME A;  4ON1 A;  1HV5 A;  1HFS A;  1A85 A;  1R1I A;  2RJP A;  2CKI A;  3LIR A;  2OZR A;  1HFC A;  4DF9 A;  4CTH A;  2L0R A;  1BIW A;  3HBV P;  4WZV A;  2XS3 A;  3P1V A;  5D1S A;  1B3D A;  1DTH A;  4PKV A;  1XM5 A;  4DD8 A;  1WNI A;  5H8X A;  3LKA A;  4IUW A;  456C A;  1AYK A;  2MLR A;  1PWQ A;  4L7A A;  1JKY A;  1YOU A;  1D5J A;  4A7B A;  2OXU A;  1XUR A;  1QIA A;  1MMB A;  4H84 A;  1HTD A;  3EDH A;  1JAQ A;  1GXD A;  3K7L A;  3ZVS A;  3NX7 A; 
#chains in the Genus database with same CATH homology
 2XS4 A;  4L19 A;  5I0L A;  3LUM A;  3F18 A;  3I7I A;  1AST A;  3MA2 A;  5D3C A;  1G9K A;  4QKZ A;  1UEA A;  5JMY A;  1SAT A;  1ZTQ A;  4R3V A;  1XFY A;  2W14 A;  3P24 A;  3DTE A;  1CGF A;  3HDA P;  1G12 A;  3EHX A;  1EB6 A;  3AYK A;  2PJT A;  4JPA A;  3EDI A;  5BOY A;  1PWU A;  2JT6 A;  4PKU A;  3RTS A;  2MZH A;  3F1A A;  1UTT A;  3RTT A;  4XM6 A;  2USN A;  1FM1 A;  1XFU A;  2MZI A;  3N2V A;  1MMQ A;  4HX3 A;  3O64 A;  3CKI A;  2ERQ A;  2OW2 A;  3V96 B;  3WV2 A;  1HOV A;  3F19 A;  1KUK A;  1IAA A;  1CXV A;  1SLN A;  3KMC A;  3O2X A;  1G49 A;  1CQR A;  1OS9 A;  1ND1 A;  5D7W A;  4A3W A;  4WF6 A;  5BPA A;  1IAD A;  2DDF A;  4Q1L A;  1RMZ A;  2N8R A;  1JAO A;  2I47 A;  1G4K A;  4DV8 A;  1OM7 A;  4DPE A;  1H71 P;  3KEC A;  3ELM A;  5I2Z A;  3DPE A;  1JIZ A;  1BQQ M;  1MMR A;  4JP4 A;  1JK3 A;  2WO9 A;  4PKQ A;  1EAK A;  5I4O A;  1SU3 A;  4GUY A;  2V4B A;  2YUF A;  5I12 A;  4FXQ A;  3UVC A;  2OY2 A;  4JQG A;  1GO8 P;  1L6J A;  1CGL A;  1BUV M;  1QUA A;  4XM7 A;  3Q2G A;  2JT5 A;  2K9C A;  1Y93 A;  4FVL A;  1UTZ A;  2QPJ A;  3DL1 A;  1BKC I;  1CIZ A;  3EDG A;  1ZXV A;  3L0V A;  1C3I A;  2W0D A;  4HMA A;  3TS4 A;  4GR8 A;  1R54 A;  3N2U A;  5I43 A;  3Q2H A;  1QJJ A;  4IJO A;  5B5P A;  5L7F A;  4I03 A;  1DMT A;  3LGP A;  3DTI A;  1AKL A;  3LE9 A;  3LQ0 A;  3U1R A;  5D2B A;  1Z3J A;  2X7M A;  1D8M A;  4WKE A;  1S4B P;  1QIB A;  2TCL A;  4H76 A;  1G05 A;  1YQY A;  2POJ A;  2W13 A;  1SRP A;  3G5C A;  3KEJ A;  3G42 A;  3HY7 A;  2DW1 A;  2D1O A;  5D1U A;  1KBC A;  1CGE A;  1GE5 A;  3LIL A;  4H49 A;  1BKC A;  1BSW A;  3DSL A;  4J4M A;  2FV5 A;  2OVZ A;  3GBO A;  1OO9 A;  1D8F A;  4AYK A;  1JAP A;  1FLS A;  4ZR5 A;  1C8T A;  3DTK A;  2OVX A;  2OXZ A;  3LQB A;  4G9L A;  3HYG A;  2CLT A;  2MLS A;  3F15 A;  1Q3A A;  4IN9 A;  1USN A;  1XUD A;  3TSK A;  2E3X A;  1K7G A;  1PWW A;  1OM8 A;  2X3C A;  1D7X A;  1GKD A;  2WOA A;  3LJG A;  3DNG A;  3KHI A;  4XM8 A;  1FBL A;  4XBH A;  2OW9 A;  1RM8 A;  1O0T A;  1JAN A;  1KUH A;  3WV1 A;  2OY4 A;  2ERO A;  3HY9 A;  3OHO A;  2O36 A;  4ILW D;  4PKW A;  2SRT A;  3F17 A;  1C7K A;  4AXQ A;  3DPF A;  4G0D A;  3DWB A;  1CK7 A;  1BUD A;  1JH1 A;  2DDY A;  2KRJ A;  4XCT A;  5LAB A;  1JIW P;  2OW0 A;  1R55 A;  1R1J A;  4JA1 A;  3HB2 P;  2DW0 A;  1ATL A;  3LK8 A;  4GR3 A;  1GO7 P;  4WKI A;  2D1N A;  1I1I P;  1K7Q A;  2X3B A;  1MNC A;  1BQO A;  1XFW A;  1EUB A;  4GWM A;  3L0T A;  2OW1 A;  2ERP A;  1B8Y A;  3AIG A;  3B8Z A;  1A86 A;  5CZM A;  2MZE A;  4FXY P;  2WO8 A;  3BA0 A;  1MMP A;  1ZP5 A;  1SLM A;  5BOT A;  1ROS A;  1IAC A;  4I35 A;  1YCM A;  3VTG A;  4EFS A;  3LJZ A;  4FU4 A;  3TT4 A;  4H30 A;  1YP1 A;  2AIG P;  3LIK A;  3LMC A;  2Y6D A;  1IAB A;  1PWP A;  3KWV C;  1R1H A;  3VI1 A;  4AUO A;  4PKR A;  3EHY A;  1I73 A;  1CAQ A;  4GWN A;  3F16 A;  3AYU A;  1KUG A;  3LUN A;  2J0T A;  3KRY A;  3LJT A;  4GQL A;  2O3E A;  2X3A A;  2DW2 A;  4PKT A;  2E2D A;  3TVC A;  3USN A;  3I7G A;  966C A;  1Y8J A;  4H82 A;  2JSD A;  2J83 A;  4AIG A;  1BM6 A;  1K7I A;  1Y0V A;  3HDB A;  2A8H A;  1OMJ A;  1OM6 A;  3HBU P;  830C A;  1SMP A;  2K2G A;  2FV9 A;  1XFZ A;  1JJ9 A;  3LEA A;  1GKC A;  1I76 A;  1KUI A;  5L79 A;  1QIC A;  1AF0 A;  4L63 A;  4H2E A;  1UMS A;  2HU6 A;  1HY7 A;  2YIG A;  2Y6C A;  2W12 A;  1QJI A;  4L6T A;  1ZXC A;  3ZXH A;  5D1T A;  3B2Z A;  4H3X A;  1O0Q A;  5CXA A;  2RJQ A;  4GR0 A;  2Z2D A;  1BKC E;  1IAG A;  3EWJ A;  5B5O A;  1GE7 A;  2W15 A;  3K7N A;  1UMT A;  4GF1 A;  2AYK A;  4H1Q A;  3WV3 A;  1IAE A;  3E8R A;  1XFX A;  1ZS0 A;  1XFV A;  3ZUK A;  2YB9 A;  5I3M A;  1GE6 A;  3KEK A;  5CUH A;  3SHI A;  4WK7 A;  2OI0 A;  4PKS A;  1OS2 A;  2JIH A;  1PWV A;  1J7N A;  3EDZ A;  4JIJ A;  3B92 A;  2OXW A;  3OHL A;  1KUF A;  1KAP P;  2JNP A;  1ZVX A;  1BZS A;  1XUC A;  3KME A;  4ON1 A;  1HV5 A;  1HFS A;  1A85 A;  1R1I A;  2RJP A;  2CKI A;  3LIR A;  2OZR A;  1HFC A;  4DF9 A;  4CTH A;  2L0R A;  1BIW A;  3HBV P;  4WZV A;  2XS3 A;  3P1V A;  5D1S A;  1B3D A;  1DTH A;  4PKV A;  4DD8 A;  1WNI A;  5H8X A;  3LKA A;  4IUW A;  456C A;  1AYK A;  2MLR A;  1PWQ A;  4L7A A;  1JKY A;  1YOU A;  1D5J A;  4A7B A;  2OXU A;  1XUR A;  1QIA A;  1MMB A;  4H84 A;  1HTD A;  3EDH A;  1JAQ A;  1GXD A;  3K7L A;  3ZVS A;  3NX7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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