3G42A

Crystal structure of tace with tryptophan sulfonamide derivative inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
254
structure length
254
Chain Sequence
MKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords ADAM 17
total genus 84
structure length 254
sequence length 254
chains with identical sequence B, C, D
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2009-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3g42A00
1JH1A 3HYGA 4FXYP 1FLSA 4A7BA 4H84A 1RMZA 4PKRA 3KECA 4GR0A 2W13A 1GE5A 4DV8A 4XM7A 1JIZA 4HX3A 3F15A 5CXAA 4AUOA 5I12A 2CKIA 4WKIA 1Y8JA 3DWBA 1BM6A 2W0DA 1JANA 4PKWA 2OXUA 1KUKA 1G05A 4I35A 3ZUKA 3GBOA 4A3WA 2OVXA 2O36A 3WV2A 1AYKA 3LQBA 3HY9A 3EHXA 1I76A 1O0TA 3HY7A 1JK3A 2XS4A 3BA0A 1HY7A 1MMQA 1UEAA 4ZR5A 1XURA 3EWJA 1UMTA 4CTHA 3K7NA 1I1IP 3USNA 1JAOA 2YB9A 3DL1A 1D7XA 4WZVA 5D3CA 1JAQA 4GF1A 3LK8A 1XUDA 1BIWA 4AXQA 3HBVP 1JJ9A 4H3XA 3LILA 1OO9A 3LIKA 1MMBA 4JQGA 3F16A 1ZXVA 1PWQA 1XFVA 5D2BA 3LMCA 1IAAA 2ERPA 4XBHA 1Z3JA 2MLSA 5LABA 3P24A 3DPFA 5CZMA 2L0RA 5B5PA 1RM8A 1H71P 4PKVA 2AYKA 3Q2HA 1BSWA 2X7MA 1ND1A 1QIBA 4ILWD 1GE7A 1G49A 2K2GA 1C8TA 3NX7A 4GUYA 5I2ZA 4L63A 3HDBA 1HV5A 3TT4A 3ZXHA 3F17A 2JNPA 2MZIA 2K9CA 5I3MA 1C7KA 3KEKA 2X3CA 4XM6A 3U1RA 4HMAA 1YCMA 1CAQA 1FM1A 2FV5A 1BQQM 3EHYA 1Y93A 1QICA 1ZTQA 1B8YA 1Y0VA 3N2VA 4H2EA 3E8RA 1K7QA 1KAPP 3N2UA 2MZEA 4XCTA 5D1TA 3L0TA 1FBLA 1MMPA 4J4MA 3KHIA 5L7FA 3F18A 2DW2A 2QPJA 456CA 5BOTA 4ON1A 2OZRA 5I4OA 3KRYA 3LEAA 1ASTA 2RJQA 1IAGA 2MZHA 3HDAP 1HFCA 2AIGP 3DPEA 2SRTA 1C3IA 1R1JA 3LJZA 2I47A 2PJTA 2OVZA 4PKSA 3DSLA 4G0DA 4H1QA 4JP4A 4WKEA 1UTZA 1BKCE 3KMEA 4JPAA 5D7WA 1JIWP 2YIGA 2OXZA 3KMCA 1IADA 3EDIA 1HFSA 4FVLA 2OI0A 1BUVM 3ZVSA 1DTHA 1USNA 2E2DA 4FXQA 4EFSA 1KUFA 1R55A 1SMPA 2MLRA 4GWNA 3EDZA 3TS4A 1CGFA 5BOYA 1WNIA 3VTGA 2OW9A 1G12A 3AIGA 2POJA 3AYUA 1BQOA 2JIHA 3HB2P 5JMYA 1BZSA 2DDYA 1SRPA 4DF9A 1ZVXA 5D1SA 2OW2A 1IABA 3WV3A 3F19A 1BKCA 1PWUA 1QIAA 1CGLA 3WV1A 3SHIA 1XUCA 1XFWA 3UVCA 3Q2GA 1SLNA 4GQLA 4I03A 2X3BA 2W14A 1D8MA 3EDGA 1MMRA 4PKQA 3O2XA 1EAKA 2DW1A 1AKLA 1ZS0A 3LGPA 2EROA 1YP1A 5I0LA 3OHLA 2A8HA 1D8FA 1S4BP 2USNA 3LUNA 3LE9A 1CGEA 2WO9A 4JA1A 3LKAA 3O64A 1GE6A 2D1OA 1R1IA 3HBUP 1EB6A 3DNGA 1EUBA 1CK7A 5B5OA 1DMTA 2X3AA 1UMSA 2V4BA 2KRJA 2OXWA 3I7GA 2E3XA 4Q1LA 3MA2A 4IUWA 1HTDA 5BPAA 3VI1A 1OMJA 1BUDA 1GKCA 1GO7P 4L19A 1CIZA 1XFXA 2WOAA 1CQRA 1PWVA 3V96B 3LJGA 1O0QA 2Z2DA 4IJOA 4AYKA 4GR3A 1J7NA 1D5JA 2O3EA 3RTTA 3F1AA 2JT6A 2DDFA 1MNCA 1I73A 1KUIA 3EDHA 2TCLA 3I7IA 3LIRA 5H8XA 2W12A 4H49A 4PKTA 3CKIA 1XFZA 1SATA 3RTSA 2ERQA 2FV9A 4DD8A 1OM7A 1UTTA 2XS3A 1HOVA 1YQYA 2N8RA 3LUMA 1ROSA 1JKYA 1R54A 4L6TA 3ELMA 1PWPA 3G42A 2OW1A 1G9KA 2DW0A 3K7LA 3KEJA 4G9LA 2Y6CA 3B8ZA 1ATLA 1GKDA 830CA 5D1UA 3B2ZA 4WK7A 1OM6A 1G4KA 2W15A 1A85A 4AIGA 4PKUA 1BKCI 5CUHA 4GWMA 1YOUA 1GXDA 4JIJA 1XFUA 1ZP5A 3KWVC 4H76A 4XM8A 4DPEA 1L6JA 2J83A 2Y6DA 1K7GA 4QKZA 4R3VA 3AYKA 4H82A 1OS9A 4H30A 2JSDA 2WO8A 2RJPA 3TVCA 4GR8A 1B3DA 1QUAA 1K7IA 3B92A 3G5CA 1KBCA 2JT5A 1R1HA 1Q3AA 3OHOA 1QJIA 1OS2A 1AF0A 1A86A 1KUGA 4IN9A 1CXVA 1IAEA 1QJJA 2HU6A 5I43A 2D1NA 1SU3A 3LQ0A 3TSKA 2OY4A 3P1VA 2OW0A 3L0VA 1ZXCA 1GO8P 1SLMA 1PWWA 1JAPA 4FU4A 1KUHA 966CA 3LJTA 1IACA 4WF6A 2OY2A 5L79A 2J0TA 1XFYA 1OM8A 2CLTA
chains in the Genus database with same CATH superfamily
1JH1A 3HYGA 4FXYP 1FLSA 4A7BA 4H84A 1RMZA 4PKRA 3KECA 4GR0A 2W13A 1GE5A 4DV8A 4XM7A 1JIZA 4HX3A 3F15A 5CXAA 4AUOA 5I12A 2CKIA 4WKIA 1Y8JA 3DWBA 1BM6A 2W0DA 1JANA 4PKWA 2OXUA 1KUKA 1G05A 4I35A 3ZUKA 3GBOA 4A3WA 2OVXA 2O36A 3WV2A 1AYKA 3LQBA 3HY9A 3EHXA 1I76A 1O0TA 3HY7A 1JK3A 2XS4A 3BA0A 1HY7A 1MMQA 1UEAA 4ZR5A 1XURA 3EWJA 1UMTA 4CTHA 3K7NA 1I1IP 3USNA 1JAOA 2YB9A 3DL1A 1D7XA 4WZVA 5D3CA 1JAQA 4GF1A 3LK8A 1XUDA 1BIWA 4AXQA 3HBVP 1JJ9A 4H3XA 3LILA 1OO9A 3LIKA 1MMBA 4JQGA 3F16A 1ZXVA 1PWQA 1XFVA 5D2BA 3LMCA 1IAAA 2ERPA 4XBHA 1Z3JA 2MLSA 5LABA 3P24A 3DPFA 5CZMA 2L0RA 5B5PA 1RM8A 1H71P 4PKVA 2AYKA 3Q2HA 1BSWA 2X7MA 1ND1A 1QIBA 4ILWD 1GE7A 1G49A 1XAXA 2K2GA 1C8TA 3NX7A 4GUYA 5I2ZA 4L63A 3HDBA 1HV5A 3TT4A 3ZXHA 3F17A 2JNPA 2MZIA 2K9CA 5I3MA 1C7KA 3KEKA 2X3CA 4XM6A 3U1RA 3DTEA 4HMAA 1YCMA 1CAQA 1FM1A 2FV5A 1BQQM 3EHYA 1Y93A 1QICA 1ZTQA 1B8YA 1Y0VA 3N2VA 4H2EA 3E8RA 1K7QA 1KAPP 3N2UA 2MZEA 4XCTA 5D1TA 3L0TA 1FBLA 1MMPA 4J4MA 3KHIA 5L7FA 1XM5A 2YUFA 3F18A 2DW2A 2QPJA 456CA 5BOTA 4ON1A 2OZRA 5I4OA 3KRYA 3LEAA 1ASTA 2RJQA 1IAGA 2MZHA 3HDAP 1HFCA 2AIGP 3DPEA 2SRTA 1C3IA 1R1JA 3LJZA 2I47A 2PJTA 2OVZA 4PKSA 3DSLA 4G0DA 4H1QA 4JP4A 4WKEA 1UTZA 1BKCE 3KMEA 4JPAA 5D7WA 1JIWP 2YIGA 2OXZA 3KMCA 1IADA 3EDIA 1HFSA 4FVLA 2OI0A 1BUVM 3ZVSA 1DTHA 1USNA 2E2DA 4FXQA 4EFSA 1KUFA 1R55A 1SMPA 2MLRA 4GWNA 3EDZA 3TS4A 1CGFA 1TVIA 5BOYA 1WNIA 3VTGA 2OW9A 1G12A 3AIGA 2POJA 3AYUA 1BQOA 2JIHA 3HB2P 5JMYA 1BZSA 2DDYA 1SRPA 4DF9A 1ZVXA 5D1SA 2OW2A 1IABA 3WV3A 3F19A 1BKCA 1PWUA 1QIAA 1CGLA 3WV1A 3SHIA 1XUCA 1XFWA 3UVCA 3Q2GA 1SLNA 4GQLA 4I03A 2X3BA 2W14A 1D8MA 3EDGA 1MMRA 4PKQA 3O2XA 1EAKA 2DW1A 1AKLA 1ZS0A 3LGPA 2EROA 1YP1A 5I0LA 3OHLA 2A8HA 1D8FA 1S4BP 2USNA 3LUNA 3LE9A 1CGEA 2WO9A 4JA1A 3LKAA 3O64A 1GE6A 2D1OA 1R1IA 3HBUP 1EB6A 3DNGA 1EUBA 1CK7A 5B5OA 1DMTA 2X3AA 1UMSA 2V4BA 2KRJA 2OXWA 3I7GA 2E3XA 4Q1LA 3MA2A 4IUWA 1HTDA 5BPAA 3VI1A 1OMJA 1BUDA 1GKCA 1GO7P 4L19A 1CIZA 1XFXA 2WOAA 1CQRA 1PWVA 3V96B 3LJGA 1O0QA 2Z2DA 4IJOA 4AYKA 4GR3A 1J7NA 1D5JA 2O3EA 3RTTA 3F1AA 2JT6A 2DDFA 1MNCA 1I73A 1KUIA 3EDHA 2TCLA 3I7IA 3LIRA 5H8XA 2W12A 4H49A 4PKTA 3CKIA 1OZ9A 1XFZA 1SATA 3RTSA 2ERQA 2FV9A 4DD8A 1OM7A 1UTTA 2XS3A 1HOVA 1YQYA 2N8RA 3LUMA 1ROSA 3DTIA 1JKYA 1R54A 4L6TA 3ELMA 1PWPA 3G42A 2OW1A 1G9KA 2DW0A 3K7LA 3KEJA 4G9LA 2Y6CA 3B8ZA 1ATLA 1GKDA 830CA 5D1UA 3B2ZA 4WK7A 1OM6A 1G4KA 2W15A 1A85A 4AIGA 4PKUA 1BKCI 5CUHA 4GWMA 1YOUA 1GXDA 4JIJA 4L7AA 1XFUA 1ZP5A 3KWVC 4H76A 4XM8A 4DPEA 1L6JA 2J83A 2Y6DA 1K7GA 4QKZA 4R3VA 3AYKA 4H82A 1OS9A 4H30A 2JSDA 2WO8A 2RJPA 3TVCA 4GR8A 1B3DA 1QUAA 1K7IA 3B92A 3G5CA 1KBCA 2JT5A 1R1HA 1Q3AA 3OHOA 1QJIA 1OS2A 1AF0A 1A86A 1KUGA 4IN9A 1CXVA 1IAEA 1QJJA 2HU6A 5I43A 2D1NA 1SU3A 3LQ0A 3TSKA 2OY4A 3P1VA 2OW0A 3L0VA 1ZXCA 1GO8P 1SLMA 1PWWA 1JAPA 4FU4A 3DTKA 1KUHA 966CA 3LJTA 1IACA 4WF6A 2OY2A 5L79A 2J0TA 1XFYA 1OM8A 2CLTA
chains in the Genus database with same CATH topology
1JH1A 3HYGA 4FXYP 1FLSA 4A7BA 4H84A 1RMZA 4PKRA 3KECA 4GR0A 2W13A 1GE5A 4DV8A 4XM7A 1JIZA 4HX3A 3F15A 5CXAA 4AUOA 5I12A 2CKIA 4WKIA 1Y8JA 3DWBA 1BM6A 2W0DA 1JANA 4PKWA 2OXUA 1KUKA 1G05A 4I35A 3ZUKA 3GBOA 4A3WA 2OVXA 2O36A 3WV2A 1AYKA 3LQBA 3HY9A 3EHXA 1I76A 1O0TA 3HY7A 1JK3A 2XS4A 3BA0A 1HY7A 1MMQA 1UEAA 4ZR5A 1XURA 3EWJA 1UMTA 4CTHA 3K7NA 1I1IP 3USNA 1JAOA 2YB9A 3DL1A 1D7XA 4WZVA 5D3CA 1JAQA 4GF1A 3LK8A 1XUDA 1BIWA 4AXQA 3HBVP 1JJ9A 4H3XA 3LILA 1OO9A 3LIKA 1MMBA 4JQGA 3F16A 1ZXVA 1PWQA 1XFVA 5D2BA 3LMCA 1IAAA 2ERPA 4XBHA 1Z3JA 2MLSA 5LABA 3P24A 3DPFA 5CZMA 2L0RA 5B5PA 1RM8A 1H71P 4PKVA 2AYKA 3Q2HA 1BSWA 2X7MA 1ND1A 1QIBA 4ILWD 1GE7A 1G49A 2K2GA 1C8TA 3NX7A 4GUYA 5I2ZA 4L63A 3HDBA 1HV5A 3TT4A 3ZXHA 3F17A 2JNPA 2MZIA 2K9CA 5I3MA 1C7KA 3KEKA 2X3CA 4XM6A 3U1RA 3DTEA 4HMAA 1YCMA 1CAQA 1FM1A 2FV5A 1BQQM 3EHYA 1Y93A 1QICA 1ZTQA 1B8YA 1Y0VA 3N2VA 4H2EA 3E8RA 1K7QA 1KAPP 3N2UA 2MZEA 4XCTA 5D1TA 3L0TA 1FBLA 1MMPA 4J4MA 3KHIA 5L7FA 2YUFA 3F18A 2DW2A 2QPJA 456CA 5BOTA 4ON1A 2OZRA 5I4OA 3KRYA 3LEAA 1ASTA 2RJQA 1IAGA 2MZHA 3HDAP 1HFCA 2AIGP 3DPEA 2SRTA 1C3IA 1R1JA 3LJZA 2I47A 2PJTA 2OVZA 4PKSA 3DSLA 4G0DA 4H1QA 4JP4A 4WKEA 1UTZA 1BKCE 3KMEA 4JPAA 5D7WA 1JIWP 2YIGA 2OXZA 3KMCA 1IADA 3EDIA 1HFSA 4FVLA 2OI0A 1BUVM 3ZVSA 1DTHA 1USNA 2E2DA 4FXQA 4EFSA 1KUFA 1R55A 1SMPA 2MLRA 4GWNA 3EDZA 3TS4A 1CGFA 5BOYA 1WNIA 3VTGA 2OW9A 1G12A 3AIGA 2POJA 3AYUA 1BQOA 2JIHA 3HB2P 5JMYA 1BZSA 2DDYA 1SRPA 4DF9A 1ZVXA 5D1SA 2OW2A 1IABA 3WV3A 3F19A 1BKCA 1PWUA 1QIAA 1CGLA 3WV1A 3SHIA 1XUCA 1XFWA 3UVCA 3Q2GA 1SLNA 4GQLA 4I03A 2X3BA 2W14A 1D8MA 3EDGA 1MMRA 4PKQA 3O2XA 1EAKA 2DW1A 1AKLA 1ZS0A 3LGPA 2EROA 1YP1A 5I0LA 3OHLA 2A8HA 1D8FA 1S4BP 2USNA 3LUNA 3LE9A 1CGEA 2WO9A 4JA1A 3LKAA 3O64A 1GE6A 2D1OA 1R1IA 3HBUP 1EB6A 3DNGA 1EUBA 1CK7A 5B5OA 1DMTA 2X3AA 1UMSA 2V4BA 2KRJA 2OXWA 3I7GA 2E3XA 4Q1LA 3MA2A 4IUWA 1HTDA 5BPAA 3VI1A 1OMJA 1BUDA 1GKCA 1GO7P 4L19A 1CIZA 1XFXA 2WOAA 1CQRA 1PWVA 3V96B 3LJGA 1O0QA 2Z2DA 4IJOA 4AYKA 4GR3A 1J7NA 1D5JA 2O3EA 3RTTA 3F1AA 2JT6A 2DDFA 1MNCA 1I73A 1KUIA 3EDHA 2TCLA 3I7IA 3LIRA 5H8XA 2W12A 4H49A 4PKTA 3CKIA 1XFZA 1SATA 3RTSA 2ERQA 2FV9A 4DD8A 1OM7A 1UTTA 2XS3A 1HOVA 1YQYA 2N8RA 3LUMA 1ROSA 3DTIA 1JKYA 1R54A 4L6TA 3ELMA 1PWPA 3G42A 2OW1A 1G9KA 2DW0A 3K7LA 3KEJA 4G9LA 2Y6CA 3B8ZA 1ATLA 1GKDA 830CA 5D1UA 3B2ZA 4WK7A 1OM6A 1G4KA 2W15A 1A85A 4AIGA 4PKUA 1BKCI 5CUHA 4GWMA 1YOUA 1GXDA 4JIJA 4L7AA 1XFUA 1ZP5A 3KWVC 4H76A 4XM8A 4DPEA 1L6JA 2J83A 2Y6DA 1K7GA 4QKZA 4R3VA 3AYKA 4H82A 1OS9A 4H30A 2JSDA 2WO8A 2RJPA 3TVCA 4GR8A 1B3DA 1QUAA 1K7IA 3B92A 3G5CA 1KBCA 2JT5A 1R1HA 1Q3AA 3OHOA 1QJIA 1OS2A 1AF0A 1A86A 1KUGA 4IN9A 1CXVA 1IAEA 1QJJA 2HU6A 5I43A 2D1NA 1SU3A 3LQ0A 3TSKA 2OY4A 3P1VA 2OW0A 3L0VA 1ZXCA 1GO8P 1SLMA 1PWWA 1JAPA 4FU4A 3DTKA 1KUHA 966CA 3LJTA 1IACA 4WF6A 2OY2A 5L79A 2J0TA 1XFYA 1OM8A 2CLTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JH1 A;  3HYG A;  4FXY P;  1FLS A;  4A7B A;  4H84 A;  1RMZ A;  4PKR A;  3KEC A;  4GR0 A;  2W13 A;  1GE5 A;  4DV8 A;  4XM7 A;  1JIZ A;  4HX3 A;  3F15 A;  5CXA A;  4AUO A;  5I12 A;  2CKI A;  4WKI A;  1Y8J A;  3DWB A;  1BM6 A;  2W0D A;  1JAN A;  4PKW A;  2OXU A;  1KUK A;  1G05 A;  4I35 A;  3ZUK A;  3GBO A;  4A3W A;  2OVX A;  2O36 A;  3WV2 A;  1AYK A;  3LQB A;  3HY9 A;  3EHX A;  1I76 A;  1O0T A;  3HY7 A;  1JK3 A;  2XS4 A;  3BA0 A;  1HY7 A;  1MMQ A;  1UEA A;  4ZR5 A;  1XUR A;  3EWJ A;  1UMT A;  4CTH A;  3K7N A;  1I1I P;  3USN A;  1JAO A;  2YB9 A;  3DL1 A;  1D7X A;  4WZV A;  5D3C A;  1JAQ A;  4GF1 A;  3LK8 A;  1XUD A;  1BIW A;  4AXQ A;  3HBV P;  1JJ9 A;  4H3X A;  3LIL A;  1OO9 A;  3LIK A;  1MMB A;  4JQG A;  3F16 A;  1ZXV A;  1PWQ A;  1XFV A;  5D2B A;  3LMC A;  1IAA A;  2ERP A;  4XBH A;  1Z3J A;  2MLS A;  5LAB A;  3P24 A;  3DPF A;  5CZM A;  2L0R A;  5B5P A;  1RM8 A;  1H71 P;  4PKV A;  2AYK A;  3Q2H A;  1BSW A;  2X7M A;  1ND1 A;  1QIB A;  4ILW D;  1GE7 A;  1G49 A;  2K2G A;  1C8T A;  3NX7 A;  4GUY A;  5I2Z A;  4L63 A;  3HDB A;  1HV5 A;  3TT4 A;  3ZXH A;  3F17 A;  2JNP A;  2MZI A;  2K9C A;  5I3M A;  1C7K A;  3KEK A;  2X3C A;  4XM6 A;  3U1R A;  4HMA A;  1YCM A;  1CAQ A;  1FM1 A;  2FV5 A;  1BQQ M;  3EHY A;  1Y93 A;  1QIC A;  1ZTQ A;  1B8Y A;  1Y0V A;  3N2V A;  4H2E A;  3E8R A;  1K7Q A;  1KAP P;  3N2U A;  2MZE A;  4XCT A;  5D1T A;  3L0T A;  1FBL A;  1MMP A;  4J4M A;  3KHI A;  5L7F A;  3F18 A;  2DW2 A;  2QPJ A;  456C A;  5BOT A;  4ON1 A;  2OZR A;  5I4O A;  3KRY A;  3LEA A;  1AST A;  2RJQ A;  1IAG A;  2MZH A;  3HDA P;  1HFC A;  2AIG P;  3DPE A;  2SRT A;  1C3I A;  1R1J A;  3LJZ A;  2I47 A;  2PJT A;  2OVZ A;  4PKS A;  3DSL A;  4G0D A;  4H1Q A;  4JP4 A;  4WKE A;  1UTZ A;  1BKC E;  3KME A;  4JPA A;  5D7W A;  1JIW P;  2YIG A;  2OXZ A;  3KMC A;  1IAD A;  3EDI A;  1HFS A;  4FVL A;  2OI0 A;  1BUV M;  3ZVS A;  1DTH A;  1USN A;  2E2D A;  4FXQ A;  4EFS A;  1KUF A;  1R55 A;  1SMP A;  2MLR A;  4GWN A;  3EDZ A;  3TS4 A;  1CGF A;  5BOY A;  1WNI A;  3VTG A;  2OW9 A;  1G12 A;  3AIG A;  2POJ A;  3AYU A;  1BQO A;  2JIH A;  3HB2 P;  5JMY A;  1BZS A;  2DDY A;  1SRP A;  4DF9 A;  1ZVX A;  5D1S A;  2OW2 A;  1IAB A;  3WV3 A;  3F19 A;  1BKC A;  1PWU A;  1QIA A;  1CGL A;  3WV1 A;  3SHI A;  1XUC A;  1XFW A;  3UVC A;  3Q2G A;  1SLN A;  4GQL A;  4I03 A;  2X3B A;  2W14 A;  1D8M A;  3EDG A;  1MMR A;  4PKQ A;  3O2X A;  1EAK A;  2DW1 A;  1AKL A;  1ZS0 A;  3LGP A;  2ERO A;  1YP1 A;  5I0L A;  3OHL A;  2A8H A;  1D8F A;  1S4B P;  2USN A;  3LUN A;  3LE9 A;  1CGE A;  2WO9 A;  4JA1 A;  3LKA A;  3O64 A;  1GE6 A;  2D1O A;  1R1I A;  3HBU P;  1EB6 A;  3DNG A;  1EUB A;  1CK7 A;  5B5O A;  1DMT A;  2X3A A;  1UMS A;  2V4B A;  2KRJ A;  2OXW A;  3I7G A;  2E3X A;  4Q1L A;  3MA2 A;  4IUW A;  1HTD A;  5BPA A;  3VI1 A;  1OMJ A;  1BUD A;  1GKC A;  1GO7 P;  4L19 A;  1CIZ A;  1XFX A;  2WOA A;  1CQR A;  1PWV A;  3V96 B;  3LJG A;  1O0Q A;  2Z2D A;  4IJO A;  4AYK A;  4GR3 A;  1J7N A;  1D5J A;  2O3E A;  3RTT A;  3F1A A;  2JT6 A;  2DDF A;  1MNC A;  1I73 A;  1KUI A;  3EDH A;  2TCL A;  3I7I A;  3LIR A;  5H8X A;  2W12 A;  4H49 A;  4PKT A;  3CKI A;  1XFZ A;  1SAT A;  3RTS A;  2ERQ A;  2FV9 A;  4DD8 A;  1OM7 A;  1UTT A;  2XS3 A;  1HOV A;  1YQY A;  2N8R A;  3LUM A;  1ROS A;  1JKY A;  1R54 A;  4L6T A;  3ELM A;  1PWP A;  3G42 A;  2OW1 A;  1G9K A;  2DW0 A;  3K7L A;  3KEJ A;  4G9L A;  2Y6C A;  3B8Z A;  1ATL A;  1GKD A;  830C A;  5D1U A;  3B2Z A;  4WK7 A;  1OM6 A;  1G4K A;  2W15 A;  1A85 A;  4AIG A;  4PKU A;  1BKC I;  5CUH A;  4GWM A;  1YOU A;  1GXD A;  4JIJ A;  1XFU A;  1ZP5 A;  3KWV C;  4H76 A;  4XM8 A;  4DPE A;  1L6J A;  2J83 A;  2Y6D A;  1K7G A;  4QKZ A;  4R3V A;  3AYK A;  4H82 A;  1OS9 A;  4H30 A;  2JSD A;  2WO8 A;  2RJP A;  3TVC A;  4GR8 A;  1B3D A;  1QUA A;  1K7I A;  3B92 A;  3G5C A;  1KBC A;  2JT5 A;  1R1H A;  1Q3A A;  3OHO A;  1QJI A;  1OS2 A;  1AF0 A;  1A86 A;  1KUG A;  4IN9 A;  1CXV A;  1IAE A;  1QJJ A;  2HU6 A;  5I43 A;  2D1N A;  1SU3 A;  3LQ0 A;  3TSK A;  2OY4 A;  3P1V A;  2OW0 A;  3L0V A;  1ZXC A;  1GO8 P;  1SLM A;  1PWW A;  1JAP A;  4FU4 A;  1KUH A;  966C A;  3LJT A;  1IAC A;  4WF6 A;  2OY2 A;  5L79 A;  2J0T A;  1XFY A;  1OM8 A;  2CLT A; 
#chains in the Genus database with same CATH topology
 1JH1 A;  3HYG A;  4FXY P;  1FLS A;  4A7B A;  4H84 A;  1RMZ A;  4PKR A;  3KEC A;  4GR0 A;  2W13 A;  1GE5 A;  4DV8 A;  4XM7 A;  1JIZ A;  4HX3 A;  3F15 A;  5CXA A;  4AUO A;  5I12 A;  2CKI A;  4WKI A;  1Y8J A;  3DWB A;  1BM6 A;  2W0D A;  1JAN A;  4PKW A;  2OXU A;  1KUK A;  1G05 A;  4I35 A;  3ZUK A;  3GBO A;  4A3W A;  2OVX A;  2O36 A;  3WV2 A;  1AYK A;  3LQB A;  3HY9 A;  3EHX A;  1I76 A;  1O0T A;  3HY7 A;  1JK3 A;  2XS4 A;  3BA0 A;  1HY7 A;  1MMQ A;  1UEA A;  4ZR5 A;  1XUR A;  3EWJ A;  1UMT A;  4CTH A;  3K7N A;  1I1I P;  3USN A;  1JAO A;  2YB9 A;  3DL1 A;  1D7X A;  4WZV A;  5D3C A;  1JAQ A;  4GF1 A;  3LK8 A;  1XUD A;  1BIW A;  4AXQ A;  3HBV P;  1JJ9 A;  4H3X A;  3LIL A;  1OO9 A;  3LIK A;  1MMB A;  4JQG A;  3F16 A;  1ZXV A;  1PWQ A;  1XFV A;  5D2B A;  3LMC A;  1IAA A;  2ERP A;  4XBH A;  1Z3J A;  2MLS A;  5LAB A;  3P24 A;  3DPF A;  5CZM A;  2L0R A;  5B5P A;  1RM8 A;  1H71 P;  4PKV A;  2AYK A;  3Q2H A;  1BSW A;  2X7M A;  1ND1 A;  1QIB A;  4ILW D;  1GE7 A;  1G49 A;  1XAX A;  2K2G A;  1C8T A;  3NX7 A;  4GUY A;  5I2Z A;  4L63 A;  3HDB A;  1HV5 A;  3TT4 A;  3ZXH A;  3F17 A;  2JNP A;  2MZI A;  2K9C A;  5I3M A;  1C7K A;  3KEK A;  2X3C A;  4XM6 A;  3U1R A;  3DTE A;  4HMA A;  1YCM A;  1CAQ A;  1FM1 A;  2FV5 A;  1BQQ M;  3EHY A;  1Y93 A;  1QIC A;  1ZTQ A;  1B8Y A;  1Y0V A;  3N2V A;  4H2E A;  3E8R A;  1K7Q A;  1KAP P;  3N2U A;  2MZE A;  4XCT A;  5D1T A;  3L0T A;  1FBL A;  1MMP A;  4J4M A;  3KHI A;  5L7F A;  1XM5 A;  2YUF A;  3F18 A;  2DW2 A;  2QPJ A;  456C A;  5BOT A;  4ON1 A;  2OZR A;  5I4O A;  3KRY A;  3LEA A;  1AST A;  2RJQ A;  1IAG A;  2MZH A;  3HDA P;  1HFC A;  2AIG P;  3DPE A;  2SRT A;  1C3I A;  1R1J A;  3LJZ A;  2I47 A;  2PJT A;  2OVZ A;  4PKS A;  3DSL A;  4G0D A;  4H1Q A;  4JP4 A;  4WKE A;  1UTZ A;  1BKC E;  3KME A;  4JPA A;  5D7W A;  1JIW P;  2YIG A;  2OXZ A;  3KMC A;  1IAD A;  3EDI A;  1HFS A;  4FVL A;  2OI0 A;  1BUV M;  3ZVS A;  1DTH A;  1USN A;  2E2D A;  4FXQ A;  4EFS A;  1KUF A;  1R55 A;  1SMP A;  2MLR A;  4GWN A;  3EDZ A;  3TS4 A;  1CGF A;  1TVI A;  5BOY A;  1WNI A;  3VTG A;  2OW9 A;  1G12 A;  3AIG A;  2POJ A;  3AYU A;  1BQO A;  2JIH A;  3HB2 P;  5JMY A;  1BZS A;  2DDY A;  1SRP A;  4DF9 A;  1ZVX A;  5D1S A;  2OW2 A;  1IAB A;  3WV3 A;  3F19 A;  1BKC A;  1PWU A;  1QIA A;  1CGL A;  3WV1 A;  3SHI A;  1XUC A;  1XFW A;  3UVC A;  3Q2G A;  1SLN A;  4GQL A;  4I03 A;  2X3B A;  2W14 A;  1D8M A;  3EDG A;  1MMR A;  4PKQ A;  3O2X A;  1EAK A;  2DW1 A;  1AKL A;  1ZS0 A;  3LGP A;  2ERO A;  1YP1 A;  5I0L A;  3OHL A;  2A8H A;  1D8F A;  1S4B P;  2USN A;  3LUN A;  3LE9 A;  1CGE A;  2WO9 A;  4JA1 A;  3LKA A;  3O64 A;  1GE6 A;  2D1O A;  1R1I A;  3HBU P;  1EB6 A;  3DNG A;  1EUB A;  1CK7 A;  5B5O A;  1DMT A;  2X3A A;  1UMS A;  2V4B A;  2KRJ A;  2OXW A;  3I7G A;  2E3X A;  4Q1L A;  3MA2 A;  4IUW A;  1HTD A;  5BPA A;  3VI1 A;  1OMJ A;  1BUD A;  1GKC A;  1GO7 P;  4L19 A;  1CIZ A;  1XFX A;  2WOA A;  1CQR A;  1PWV A;  3V96 B;  3LJG A;  1O0Q A;  2Z2D A;  4IJO A;  4AYK A;  4GR3 A;  1J7N A;  1D5J A;  2O3E A;  3RTT A;  3F1A A;  2JT6 A;  2DDF A;  1MNC A;  1I73 A;  1KUI A;  3EDH A;  2TCL A;  3I7I A;  3LIR A;  5H8X A;  2W12 A;  4H49 A;  4PKT A;  3CKI A;  1OZ9 A;  1XFZ A;  1SAT A;  3RTS A;  2ERQ A;  2FV9 A;  4DD8 A;  1OM7 A;  1UTT A;  2XS3 A;  1HOV A;  1YQY A;  2N8R A;  3LUM A;  1ROS A;  3DTI A;  1JKY A;  1R54 A;  4L6T A;  3ELM A;  1PWP A;  3G42 A;  2OW1 A;  1G9K A;  2DW0 A;  3K7L A;  3KEJ A;  4G9L A;  2Y6C A;  3B8Z A;  1ATL A;  1GKD A;  830C A;  5D1U A;  3B2Z A;  4WK7 A;  1OM6 A;  1G4K A;  2W15 A;  1A85 A;  4AIG A;  4PKU A;  1BKC I;  5CUH A;  4GWM A;  1YOU A;  1GXD A;  4JIJ A;  4L7A A;  1XFU A;  1ZP5 A;  3KWV C;  4H76 A;  4XM8 A;  4DPE A;  1L6J A;  2J83 A;  2Y6D A;  1K7G A;  4QKZ A;  4R3V A;  3AYK A;  4H82 A;  1OS9 A;  4H30 A;  2JSD A;  2WO8 A;  2RJP A;  3TVC A;  4GR8 A;  1B3D A;  1QUA A;  1K7I A;  3B92 A;  3G5C A;  1KBC A;  2JT5 A;  1R1H A;  1Q3A A;  3OHO A;  1QJI A;  1OS2 A;  1AF0 A;  1A86 A;  1KUG A;  4IN9 A;  1CXV A;  1IAE A;  1QJJ A;  2HU6 A;  5I43 A;  2D1N A;  1SU3 A;  3LQ0 A;  3TSK A;  2OY4 A;  3P1V A;  2OW0 A;  3L0V A;  1ZXC A;  1GO8 P;  1SLM A;  1PWW A;  1JAP A;  4FU4 A;  3DTK A;  1KUH A;  966C A;  3LJT A;  1IAC A;  4WF6 A;  2OY2 A;  5L79 A;  2J0T A;  1XFY A;  1OM8 A;  2CLT A; 
#chains in the Genus database with same CATH homology
 1JH1 A;  3HYG A;  4FXY P;  1FLS A;  4A7B A;  4H84 A;  1RMZ A;  4PKR A;  3KEC A;  4GR0 A;  2W13 A;  1GE5 A;  4DV8 A;  4XM7 A;  1JIZ A;  4HX3 A;  3F15 A;  5CXA A;  4AUO A;  5I12 A;  2CKI A;  4WKI A;  1Y8J A;  3DWB A;  1BM6 A;  2W0D A;  1JAN A;  4PKW A;  2OXU A;  1KUK A;  1G05 A;  4I35 A;  3ZUK A;  3GBO A;  4A3W A;  2OVX A;  2O36 A;  3WV2 A;  1AYK A;  3LQB A;  3HY9 A;  3EHX A;  1I76 A;  1O0T A;  3HY7 A;  1JK3 A;  2XS4 A;  3BA0 A;  1HY7 A;  1MMQ A;  1UEA A;  4ZR5 A;  1XUR A;  3EWJ A;  1UMT A;  4CTH A;  3K7N A;  1I1I P;  3USN A;  1JAO A;  2YB9 A;  3DL1 A;  1D7X A;  4WZV A;  5D3C A;  1JAQ A;  4GF1 A;  3LK8 A;  1XUD A;  1BIW A;  4AXQ A;  3HBV P;  1JJ9 A;  4H3X A;  3LIL A;  1OO9 A;  3LIK A;  1MMB A;  4JQG A;  3F16 A;  1ZXV A;  1PWQ A;  1XFV A;  5D2B A;  3LMC A;  1IAA A;  2ERP A;  4XBH A;  1Z3J A;  2MLS A;  5LAB A;  3P24 A;  3DPF A;  5CZM A;  2L0R A;  5B5P A;  1RM8 A;  1H71 P;  4PKV A;  2AYK A;  3Q2H A;  1BSW A;  2X7M A;  1ND1 A;  1QIB A;  4ILW D;  1GE7 A;  1G49 A;  2K2G A;  1C8T A;  3NX7 A;  4GUY A;  5I2Z A;  4L63 A;  3HDB A;  1HV5 A;  3TT4 A;  3ZXH A;  3F17 A;  2JNP A;  2MZI A;  2K9C A;  5I3M A;  1C7K A;  3KEK A;  2X3C A;  4XM6 A;  3U1R A;  3DTE A;  4HMA A;  1YCM A;  1CAQ A;  1FM1 A;  2FV5 A;  1BQQ M;  3EHY A;  1Y93 A;  1QIC A;  1ZTQ A;  1B8Y A;  1Y0V A;  3N2V A;  4H2E A;  3E8R A;  1K7Q A;  1KAP P;  3N2U A;  2MZE A;  4XCT A;  5D1T A;  3L0T A;  1FBL A;  1MMP A;  4J4M A;  3KHI A;  5L7F A;  2YUF A;  3F18 A;  2DW2 A;  2QPJ A;  456C A;  5BOT A;  4ON1 A;  2OZR A;  5I4O A;  3KRY A;  3LEA A;  1AST A;  2RJQ A;  1IAG A;  2MZH A;  3HDA P;  1HFC A;  2AIG P;  3DPE A;  2SRT A;  1C3I A;  1R1J A;  3LJZ A;  2I47 A;  2PJT A;  2OVZ A;  4PKS A;  3DSL A;  4G0D A;  4H1Q A;  4JP4 A;  4WKE A;  1UTZ A;  1BKC E;  3KME A;  4JPA A;  5D7W A;  1JIW P;  2YIG A;  2OXZ A;  3KMC A;  1IAD A;  3EDI A;  1HFS A;  4FVL A;  2OI0 A;  1BUV M;  3ZVS A;  1DTH A;  1USN A;  2E2D A;  4FXQ A;  4EFS A;  1KUF A;  1R55 A;  1SMP A;  2MLR A;  4GWN A;  3EDZ A;  3TS4 A;  1CGF A;  5BOY A;  1WNI A;  3VTG A;  2OW9 A;  1G12 A;  3AIG A;  2POJ A;  3AYU A;  1BQO A;  2JIH A;  3HB2 P;  5JMY A;  1BZS A;  2DDY A;  1SRP A;  4DF9 A;  1ZVX A;  5D1S A;  2OW2 A;  1IAB A;  3WV3 A;  3F19 A;  1BKC A;  1PWU A;  1QIA A;  1CGL A;  3WV1 A;  3SHI A;  1XUC A;  1XFW A;  3UVC A;  3Q2G A;  1SLN A;  4GQL A;  4I03 A;  2X3B A;  2W14 A;  1D8M A;  3EDG A;  1MMR A;  4PKQ A;  3O2X A;  1EAK A;  2DW1 A;  1AKL A;  1ZS0 A;  3LGP A;  2ERO A;  1YP1 A;  5I0L A;  3OHL A;  2A8H A;  1D8F A;  1S4B P;  2USN A;  3LUN A;  3LE9 A;  1CGE A;  2WO9 A;  4JA1 A;  3LKA A;  3O64 A;  1GE6 A;  2D1O A;  1R1I A;  3HBU P;  1EB6 A;  3DNG A;  1EUB A;  1CK7 A;  5B5O A;  1DMT A;  2X3A A;  1UMS A;  2V4B A;  2KRJ A;  2OXW A;  3I7G A;  2E3X A;  4Q1L A;  3MA2 A;  4IUW A;  1HTD A;  5BPA A;  3VI1 A;  1OMJ A;  1BUD A;  1GKC A;  1GO7 P;  4L19 A;  1CIZ A;  1XFX A;  2WOA A;  1CQR A;  1PWV A;  3V96 B;  3LJG A;  1O0Q A;  2Z2D A;  4IJO A;  4AYK A;  4GR3 A;  1J7N A;  1D5J A;  2O3E A;  3RTT A;  3F1A A;  2JT6 A;  2DDF A;  1MNC A;  1I73 A;  1KUI A;  3EDH A;  2TCL A;  3I7I A;  3LIR A;  5H8X A;  2W12 A;  4H49 A;  4PKT A;  3CKI A;  1XFZ A;  1SAT A;  3RTS A;  2ERQ A;  2FV9 A;  4DD8 A;  1OM7 A;  1UTT A;  2XS3 A;  1HOV A;  1YQY A;  2N8R A;  3LUM A;  1ROS A;  3DTI A;  1JKY A;  1R54 A;  4L6T A;  3ELM A;  1PWP A;  3G42 A;  2OW1 A;  1G9K A;  2DW0 A;  3K7L A;  3KEJ A;  4G9L A;  2Y6C A;  3B8Z A;  1ATL A;  1GKD A;  830C A;  5D1U A;  3B2Z A;  4WK7 A;  1OM6 A;  1G4K A;  2W15 A;  1A85 A;  4AIG A;  4PKU A;  1BKC I;  5CUH A;  4GWM A;  1YOU A;  1GXD A;  4JIJ A;  4L7A A;  1XFU A;  1ZP5 A;  3KWV C;  4H76 A;  4XM8 A;  4DPE A;  1L6J A;  2J83 A;  2Y6D A;  1K7G A;  4QKZ A;  4R3V A;  3AYK A;  4H82 A;  1OS9 A;  4H30 A;  2JSD A;  2WO8 A;  2RJP A;  3TVC A;  4GR8 A;  1B3D A;  1QUA A;  1K7I A;  3B92 A;  3G5C A;  1KBC A;  2JT5 A;  1R1H A;  1Q3A A;  3OHO A;  1QJI A;  1OS2 A;  1AF0 A;  1A86 A;  1KUG A;  4IN9 A;  1CXV A;  1IAE A;  1QJJ A;  2HU6 A;  5I43 A;  2D1N A;  1SU3 A;  3LQ0 A;  3TSK A;  2OY4 A;  3P1V A;  2OW0 A;  3L0V A;  1ZXC A;  1GO8 P;  1SLM A;  1PWW A;  1JAP A;  4FU4 A;  3DTK A;  1KUH A;  966C A;  3LJT A;  1IAC A;  4WF6 A;  2OY2 A;  5L79 A;  2J0T A;  1XFY A;  1OM8 A;  2CLT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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