3LE9A

Crystal structure of the catalytic domain of tace with indazolinone-phenyl-hydantoin inhibitor
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
257
structure length
251
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Biaryl substituted hydantoin compounds as TACE inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Disintegrin and metalloproteinase domain-containing protein
total genus 81
structure length 251
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2010-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3le9A00
5I4OA 1UEAA 1JAQA 5D1UA 3EDHA 1FLSA 2OI0A 3HYGA 4PKRA 5D1TA 2SRTA 4G9LA 1ND1A 1OO9A 2X3BA 3HDAP 1DTHA 4JIJA 2YB9A 1XFUA 1PWPA 4H30A 4DF9A 4H3XA 4I35A 1GKDA 3P24A 5JMYA 4WZVA 1PWVA 1IABA 1ATLA 4IJOA 2QPJA 1OS9A 2J0TA 4PKWA 1OM8A 1KUKA 2W13A 3RTSA 1JIZA 3L0VA 1EUBA 966CA 1UMTA 5BOYA 5CXAA 2RJQA 3Q2HA 1PWQA 3F16A 4PKTA 3LIKA 1MMRA 4H49A 4H82A 3DWBA 4DPEA 1JIWP 2D1OA 4AUOA 4QKZA 1GE7A 2USNA 2X3AA 4I03A 3LUMA 5I0LA 1QIAA 3HBUP 1Y93A 2WO9A 3BA0A 3GBOA 1RM8A 3G42A 2FV9A 1R1JA 3F17A 4GR0A 1D8MA 3LJZA 2V4BA 1MNCA 2X7MA 3LEAA 2MZIA 1YCMA 3USNA 1SU3A 2OXZA 1SATA 1BSWA 3EWJA 4XM8A 1JH1A 1R55A 3O64A 3OHOA 1C3IA 4JPAA 1FBLA 1ZXVA 2O3EA 3KMEA 2DW2A 4HX3A 3LKAA 1IAAA 3LK8A 1KAPP 3V96B 3DSLA 1GKCA 5D3CA 3N2UA 1BQOA 2I47A 5CUHA 3ZXHA 1ZP5A 3HBVP 1JAPA 1BIWA 1HY7A 1K7IA 1J7NA 1B3DA 3DPEA 1BKCA 2OVZA 2JIHA 1HTDA 3ELMA 4XM6A 3AIGA 4FXQA 1IAGA 1GE6A 5BOTA 1BZSA 1UTZA 1D5JA 2L0RA 1D7XA 3KEJA 4H2EA 3I7IA 5L79A 2DW1A 1EAKA 1YP1A 1HOVA 2YIGA 1S4BP 4DD8A 3DNGA 4IUWA 4H84A 3TS4A 1I76A 1Y8JA 3F18A 4DV8A 4AIGA 1IACA 4GWNA 1XFXA 1C8TA 3NX7A 1CQRA 5I12A 4L19A 1DMTA 3B8ZA 3LQBA 1GO7P 1O0QA 1QJJA 1CIZA 4AYKA 4FU4A 3KHIA 3WV1A 4WK7A 3HY9A 5H8XA 4GQLA 1GE5A 1Z3JA 2AYKA 5I43A 3LGPA 3F15A 1KUHA 2XS4A 3KWVC 3WV3A 1IADA 4H1QA 2TCLA 1AKLA 4G0DA 2OW2A 1D8FA 4EFSA 1K7GA 5D7WA 1UMSA 1ZVXA 2DW0A 2Z2DA 1XFZA 4J4MA 1MMQA 1C7KA 1CGLA 3EDGA 2ERQA 5I3MA 3TT4A 1MMPA 1RMZA 2MZEA 3Q2GA 1WNIA 1KUGA 4WKEA 3KMCA 1ZXCA 5I2ZA 1SLMA 3I7GA 3RTTA 1R54A 830CA 5BPAA 1BQQM 1YOUA 1ZS0A 1XURA 1HFCA 4ILWD 3EHYA 2OY2A 3E8RA 5L7FA 4A7BA 5D1SA 4IN9A 3UVCA 3CKIA 2OW0A 4CTHA 4JA1A 2DDYA 4L63A 1CGEA 1SLNA 4GR3A 2E2DA 2XS3A 4GF1A 4HMAA 1UTTA 1QUAA 1G12A 4L6TA 3TSKA 1MMBA 2OXUA 2JSDA 1O0TA 1USNA 3EDIA 1G05A 1XFVA 1Y0VA 4GWMA 2JT6A 2PJTA 2OY4A 2DDFA 1ASTA 2K2GA 2EROA 1XUDA 2D1NA 1BKCI 1BUDA 3U1RA 2Y6DA 1XUCA 1QIBA 456CA 3LUNA 3P1VA 3B2ZA 1BKCE 3O2XA 3LQ0A 1OS2A 3K7NA 1ROSA 2E3XA 1OM6A 4XBHA 1JJ9A 2OXWA 3G5CA 4A3WA 1R1HA 3MA2A 2POJA 1A85A 4PKUA 4WF6A 5B5PA 2W15A 1I73A 4PKVA 3F19A 1SRPA 1ZTQA 4XCTA 3WV2A 3ZUKA 2JT5A 1G9KA 3L0TA 1HV5A 4PKSA 2CLTA 1G4KA 2O36A 2Y6CA 2WOAA 1XFYA 1IAEA 1Q3AA 2CKIA 4H76A 2N8RA 3AYUA 1KUIA 5D2BA 3KRYA 1KBCA 2K9CA 2OZRA 1JAOA 4ON1A 2RJPA 1G49A 2MLRA 5B5OA 2AIGP 1A86A 1JKYA 3AYKA 2FV5A 4WKIA 3KECA 1HFSA 3KEKA 3F1AA 2J83A 3K7LA 1B8YA 3LJGA 4FXYP 3HB2P 2A8HA 2ERPA 3B92A 4PKQA 3LILA 1CXVA 2KRJA 4JP4A 2WO8A 1AF0A 1BM6A 1JK3A 2MLSA 5CZMA 1AYKA 3HDBA 1OMJA 2JNPA 1FM1A 3HY7A 3LE9A 1KUFA 4GR8A 3ZVSA 4ZR5A 1CGFA 3OHLA 1L6JA 3TVCA 1I1IP 2W14A 4XM7A 5LABA 4JQGA 2W12A 1SMPA 1YQYA 1BUVM 1PWUA 1R1IA 1CK7A 4Q1LA 3SHIA 2OVXA 4GUYA 2X3CA 3DPFA 1GXDA 1QICA 2MZHA 1CAQA 4AXQA 3N2VA 3DL1A 1PWWA 1H71P 1XFWA 2OW9A 4FVLA 2HU6A 3EHXA 3LIRA 1EB6A 1OM7A 3VTGA 4R3VA 3VI1A 1QJIA 2W0DA 2OW1A 3LMCA 1JANA 1K7QA 3EDZA 3LJTA 1GO8P
chains in the Genus database with same CATH superfamily
5I4OA 1UEAA 1JAQA 5D1UA 3EDHA 3DTIA 1FLSA 2OI0A 3HYGA 4PKRA 5D1TA 2SRTA 4G9LA 1ND1A 1OO9A 2X3BA 3HDAP 1DTHA 1XM5A 4JIJA 2YB9A 1XFUA 1PWPA 4H30A 4DF9A 4H3XA 4I35A 1GKDA 3P24A 5JMYA 4WZVA 1PWVA 1IABA 1ATLA 4IJOA 2QPJA 1OS9A 2J0TA 4PKWA 1OM8A 1KUKA 2W13A 3RTSA 1JIZA 3L0VA 1EUBA 966CA 1UMTA 5BOYA 5CXAA 2RJQA 3Q2HA 1PWQA 3F16A 4PKTA 3LIKA 1MMRA 4H49A 4H82A 3DWBA 4DPEA 1JIWP 2D1OA 4AUOA 4QKZA 1GE7A 2USNA 2X3AA 4I03A 3LUMA 5I0LA 1QIAA 3HBUP 1Y93A 2WO9A 3BA0A 3GBOA 1RM8A 3G42A 2FV9A 1R1JA 3F17A 4GR0A 1D8MA 3LJZA 2V4BA 1MNCA 2X7MA 3LEAA 2MZIA 1YCMA 3USNA 1SU3A 2OXZA 1SATA 1BSWA 3EWJA 4XM8A 1JH1A 1R55A 3O64A 3OHOA 1C3IA 4JPAA 1FBLA 1ZXVA 2O3EA 3KMEA 2DW2A 4HX3A 3LKAA 1IAAA 3LK8A 1KAPP 3V96B 3DSLA 1GKCA 5D3CA 3N2UA 1BQOA 2I47A 5CUHA 3ZXHA 1ZP5A 3HBVP 1JAPA 1BIWA 1HY7A 1K7IA 1XAXA 1J7NA 1B3DA 3DPEA 1BKCA 2OVZA 2JIHA 1HTDA 3ELMA 4XM6A 3AIGA 4FXQA 1IAGA 1GE6A 5BOTA 1BZSA 1UTZA 3DTEA 1D5JA 2L0RA 1D7XA 3KEJA 4H2EA 3I7IA 5L79A 2DW1A 1EAKA 1YP1A 1HOVA 2YIGA 1S4BP 4DD8A 3DNGA 4IUWA 4H84A 3TS4A 1I76A 1Y8JA 3F18A 4DV8A 4AIGA 1IACA 4GWNA 1XFXA 1C8TA 3NX7A 1CQRA 5I12A 4L19A 1DMTA 4L7AA 3B8ZA 3LQBA 1GO7P 1O0QA 1QJJA 1CIZA 4AYKA 4FU4A 3KHIA 3WV1A 4WK7A 3HY9A 5H8XA 4GQLA 1GE5A 1Z3JA 2AYKA 5I43A 3LGPA 3F15A 1KUHA 2XS4A 3KWVC 3WV3A 1IADA 4H1QA 1TVIA 2TCLA 1AKLA 4G0DA 2OW2A 1D8FA 4EFSA 1K7GA 5D7WA 1UMSA 1ZVXA 2DW0A 2Z2DA 1XFZA 4J4MA 1MMQA 1C7KA 1CGLA 3EDGA 2ERQA 5I3MA 3TT4A 1MMPA 1RMZA 2MZEA 3Q2GA 1WNIA 1KUGA 4WKEA 3KMCA 1ZXCA 5I2ZA 1SLMA 3I7GA 3RTTA 1R54A 830CA 5BPAA 1BQQM 1YOUA 1ZS0A 1XURA 1HFCA 4ILWD 3EHYA 2OY2A 3E8RA 5L7FA 4A7BA 5D1SA 4IN9A 3UVCA 3CKIA 2OW0A 4CTHA 4JA1A 2DDYA 3DTKA 4L63A 1CGEA 1SLNA 4GR3A 1OZ9A 2E2DA 2XS3A 4GF1A 4HMAA 1UTTA 1QUAA 1G12A 4L6TA 3TSKA 1MMBA 2OXUA 2JSDA 1O0TA 1USNA 3EDIA 1G05A 1XFVA 1Y0VA 4GWMA 2JT6A 2PJTA 2OY4A 2DDFA 1ASTA 2K2GA 2EROA 1XUDA 2D1NA 1BKCI 1BUDA 3U1RA 2Y6DA 1XUCA 1QIBA 456CA 3LUNA 3P1VA 3B2ZA 1BKCE 3O2XA 3LQ0A 1OS2A 3K7NA 1ROSA 2E3XA 1OM6A 4XBHA 1JJ9A 2OXWA 3G5CA 4A3WA 1R1HA 3MA2A 2POJA 1A85A 4PKUA 4WF6A 5B5PA 2W15A 1I73A 4PKVA 3F19A 1SRPA 1ZTQA 4XCTA 3WV2A 3ZUKA 2JT5A 1G9KA 3L0TA 1HV5A 4PKSA 2CLTA 1G4KA 2O36A 2Y6CA 2WOAA 1XFYA 1IAEA 1Q3AA 2CKIA 4H76A 2N8RA 3AYUA 1KUIA 5D2BA 3KRYA 1KBCA 2K9CA 2OZRA 1JAOA 4ON1A 2RJPA 1G49A 2MLRA 5B5OA 2AIGP 1A86A 1JKYA 3AYKA 2FV5A 4WKIA 3KECA 1HFSA 3KEKA 3F1AA 2J83A 3K7LA 1B8YA 3LJGA 4FXYP 3HB2P 2A8HA 2ERPA 3B92A 4PKQA 3LILA 1CXVA 2KRJA 4JP4A 2WO8A 1AF0A 1BM6A 2YUFA 1JK3A 2MLSA 5CZMA 1AYKA 3HDBA 1OMJA 2JNPA 1FM1A 3HY7A 3LE9A 1KUFA 4GR8A 3ZVSA 4ZR5A 1CGFA 3OHLA 1L6JA 3TVCA 1I1IP 2W14A 4XM7A 5LABA 4JQGA 2W12A 1SMPA 1YQYA 1BUVM 1PWUA 1R1IA 1CK7A 4Q1LA 3SHIA 2OVXA 4GUYA 2X3CA 3DPFA 1GXDA 1QICA 2MZHA 1CAQA 4AXQA 3N2VA 3DL1A 1PWWA 1H71P 1XFWA 2OW9A 4FVLA 2HU6A 3EHXA 3LIRA 1EB6A 1OM7A 3VTGA 4R3VA 3VI1A 1QJIA 2W0DA 2OW1A 3LMCA 1JANA 1K7QA 3EDZA 3LJTA 1GO8P
chains in the Genus database with same CATH topology
5I4OA 1UEAA 1JAQA 5D1UA 3EDHA 3DTIA 1FLSA 2OI0A 3HYGA 4PKRA 5D1TA 2SRTA 4G9LA 1ND1A 1OO9A 2X3BA 3HDAP 1DTHA 4JIJA 2YB9A 1XFUA 1PWPA 4H30A 4DF9A 4H3XA 4I35A 1GKDA 3P24A 5JMYA 4WZVA 1PWVA 1IABA 1ATLA 4IJOA 2QPJA 1OS9A 2J0TA 4PKWA 1OM8A 1KUKA 2W13A 3RTSA 1JIZA 3L0VA 1EUBA 966CA 1UMTA 5BOYA 5CXAA 2RJQA 3Q2HA 1PWQA 3F16A 4PKTA 3LIKA 1MMRA 4H49A 4H82A 3DWBA 4DPEA 1JIWP 2D1OA 4AUOA 4QKZA 1GE7A 2USNA 2X3AA 4I03A 3LUMA 5I0LA 1QIAA 3HBUP 1Y93A 2WO9A 3BA0A 3GBOA 1RM8A 3G42A 2FV9A 1R1JA 3F17A 4GR0A 1D8MA 3LJZA 2V4BA 1MNCA 2X7MA 3LEAA 2MZIA 1YCMA 3USNA 1SU3A 2OXZA 1SATA 1BSWA 3EWJA 4XM8A 1JH1A 1R55A 3O64A 3OHOA 1C3IA 4JPAA 1FBLA 1ZXVA 2O3EA 3KMEA 2DW2A 4HX3A 3LKAA 1IAAA 3LK8A 1KAPP 3V96B 3DSLA 1GKCA 5D3CA 3N2UA 1BQOA 2I47A 5CUHA 3ZXHA 1ZP5A 3HBVP 1JAPA 1BIWA 1HY7A 1K7IA 1J7NA 1B3DA 3DPEA 1BKCA 2OVZA 2JIHA 1HTDA 3ELMA 4XM6A 3AIGA 4FXQA 1IAGA 1GE6A 5BOTA 1BZSA 1UTZA 3DTEA 1D5JA 2L0RA 1D7XA 3KEJA 4H2EA 3I7IA 5L79A 2DW1A 1EAKA 1YP1A 1HOVA 2YIGA 1S4BP 4DD8A 3DNGA 4IUWA 4H84A 3TS4A 1I76A 1Y8JA 3F18A 4DV8A 4AIGA 1IACA 4GWNA 1XFXA 1C8TA 3NX7A 1CQRA 5I12A 4L19A 1DMTA 4L7AA 3B8ZA 3LQBA 1GO7P 1O0QA 1QJJA 1CIZA 4AYKA 4FU4A 3KHIA 3WV1A 4WK7A 3HY9A 5H8XA 4GQLA 1GE5A 1Z3JA 2AYKA 5I43A 3LGPA 3F15A 1KUHA 2XS4A 3KWVC 3WV3A 1IADA 4H1QA 2TCLA 1AKLA 4G0DA 2OW2A 1D8FA 4EFSA 1K7GA 5D7WA 1UMSA 1ZVXA 2DW0A 2Z2DA 1XFZA 4J4MA 1MMQA 1C7KA 1CGLA 3EDGA 2ERQA 5I3MA 3TT4A 1MMPA 1RMZA 2MZEA 3Q2GA 1WNIA 1KUGA 4WKEA 3KMCA 1ZXCA 5I2ZA 1SLMA 3I7GA 3RTTA 1R54A 830CA 5BPAA 1BQQM 1YOUA 1ZS0A 1XURA 1HFCA 4ILWD 3EHYA 2OY2A 3E8RA 5L7FA 4A7BA 5D1SA 4IN9A 3UVCA 3CKIA 2OW0A 4CTHA 4JA1A 2DDYA 3DTKA 4L63A 1CGEA 1SLNA 4GR3A 2E2DA 2XS3A 4GF1A 4HMAA 1UTTA 1QUAA 1G12A 4L6TA 3TSKA 1MMBA 2OXUA 2JSDA 1O0TA 1USNA 3EDIA 1G05A 1XFVA 1Y0VA 4GWMA 2JT6A 2PJTA 2OY4A 2DDFA 1ASTA 2K2GA 2EROA 1XUDA 2D1NA 1BKCI 1BUDA 3U1RA 2Y6DA 1XUCA 1QIBA 456CA 3LUNA 3P1VA 3B2ZA 1BKCE 3O2XA 3LQ0A 1OS2A 3K7NA 1ROSA 2E3XA 1OM6A 4XBHA 1JJ9A 2OXWA 3G5CA 4A3WA 1R1HA 3MA2A 2POJA 1A85A 4PKUA 4WF6A 5B5PA 2W15A 1I73A 4PKVA 3F19A 1SRPA 1ZTQA 4XCTA 3WV2A 3ZUKA 2JT5A 1G9KA 3L0TA 1HV5A 4PKSA 2CLTA 1G4KA 2O36A 2Y6CA 2WOAA 1XFYA 1IAEA 1Q3AA 2CKIA 4H76A 2N8RA 3AYUA 1KUIA 5D2BA 3KRYA 1KBCA 2K9CA 2OZRA 1JAOA 4ON1A 2RJPA 1G49A 2MLRA 5B5OA 2AIGP 1A86A 1JKYA 3AYKA 2FV5A 4WKIA 3KECA 1HFSA 3KEKA 3F1AA 2J83A 3K7LA 1B8YA 3LJGA 4FXYP 3HB2P 2A8HA 2ERPA 3B92A 4PKQA 3LILA 1CXVA 2KRJA 4JP4A 2WO8A 1AF0A 1BM6A 2YUFA 1JK3A 2MLSA 5CZMA 1AYKA 3HDBA 1OMJA 2JNPA 1FM1A 3HY7A 3LE9A 1KUFA 4GR8A 3ZVSA 4ZR5A 1CGFA 3OHLA 1L6JA 3TVCA 1I1IP 2W14A 4XM7A 5LABA 4JQGA 2W12A 1SMPA 1YQYA 1BUVM 1PWUA 1R1IA 1CK7A 4Q1LA 3SHIA 2OVXA 4GUYA 2X3CA 3DPFA 1GXDA 1QICA 2MZHA 1CAQA 4AXQA 3N2VA 3DL1A 1PWWA 1H71P 1XFWA 2OW9A 4FVLA 2HU6A 3EHXA 3LIRA 1EB6A 1OM7A 3VTGA 4R3VA 3VI1A 1QJIA 2W0DA 2OW1A 3LMCA 1JANA 1K7QA 3EDZA 3LJTA 1GO8P
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5I4O A;  1UEA A;  1JAQ A;  5D1U A;  3EDH A;  1FLS A;  2OI0 A;  3HYG A;  4PKR A;  5D1T A;  2SRT A;  4G9L A;  1ND1 A;  1OO9 A;  2X3B A;  3HDA P;  1DTH A;  4JIJ A;  2YB9 A;  1XFU A;  1PWP A;  4H30 A;  4DF9 A;  4H3X A;  4I35 A;  1GKD A;  3P24 A;  5JMY A;  4WZV A;  1PWV A;  1IAB A;  1ATL A;  4IJO A;  2QPJ A;  1OS9 A;  2J0T A;  4PKW A;  1OM8 A;  1KUK A;  2W13 A;  3RTS A;  1JIZ A;  3L0V A;  1EUB A;  966C A;  1UMT A;  5BOY A;  5CXA A;  2RJQ A;  3Q2H A;  1PWQ A;  3F16 A;  4PKT A;  3LIK A;  1MMR A;  4H49 A;  4H82 A;  3DWB A;  4DPE A;  1JIW P;  2D1O A;  4AUO A;  4QKZ A;  1GE7 A;  2USN A;  2X3A A;  4I03 A;  3LUM A;  5I0L A;  1QIA A;  3HBU P;  1Y93 A;  2WO9 A;  3BA0 A;  3GBO A;  1RM8 A;  3G42 A;  2FV9 A;  1R1J A;  3F17 A;  4GR0 A;  1D8M A;  3LJZ A;  2V4B A;  1MNC A;  2X7M A;  3LEA A;  2MZI A;  1YCM A;  3USN A;  1SU3 A;  2OXZ A;  1SAT A;  1BSW A;  3EWJ A;  4XM8 A;  1JH1 A;  1R55 A;  3O64 A;  3OHO A;  1C3I A;  4JPA A;  1FBL A;  1ZXV A;  2O3E A;  3KME A;  2DW2 A;  4HX3 A;  3LKA A;  1IAA A;  3LK8 A;  1KAP P;  3V96 B;  3DSL A;  1GKC A;  5D3C A;  3N2U A;  1BQO A;  2I47 A;  5CUH A;  3ZXH A;  1ZP5 A;  3HBV P;  1JAP A;  1BIW A;  1HY7 A;  1K7I A;  1J7N A;  1B3D A;  3DPE A;  1BKC A;  2OVZ A;  2JIH A;  1HTD A;  3ELM A;  4XM6 A;  3AIG A;  4FXQ A;  1IAG A;  1GE6 A;  5BOT A;  1BZS A;  1UTZ A;  1D5J A;  2L0R A;  1D7X A;  3KEJ A;  4H2E A;  3I7I A;  5L79 A;  2DW1 A;  1EAK A;  1YP1 A;  1HOV A;  2YIG A;  1S4B P;  4DD8 A;  3DNG A;  4IUW A;  4H84 A;  3TS4 A;  1I76 A;  1Y8J A;  3F18 A;  4DV8 A;  4AIG A;  1IAC A;  4GWN A;  1XFX A;  1C8T A;  3NX7 A;  1CQR A;  5I12 A;  4L19 A;  1DMT A;  3B8Z A;  3LQB A;  1GO7 P;  1O0Q A;  1QJJ A;  1CIZ A;  4AYK A;  4FU4 A;  3KHI A;  3WV1 A;  4WK7 A;  3HY9 A;  5H8X A;  4GQL A;  1GE5 A;  1Z3J A;  2AYK A;  5I43 A;  3LGP A;  3F15 A;  1KUH A;  2XS4 A;  3KWV C;  3WV3 A;  1IAD A;  4H1Q A;  2TCL A;  1AKL A;  4G0D A;  2OW2 A;  1D8F A;  4EFS A;  1K7G A;  5D7W A;  1UMS A;  1ZVX A;  2DW0 A;  2Z2D A;  1XFZ A;  4J4M A;  1MMQ A;  1C7K A;  1CGL A;  3EDG A;  2ERQ A;  5I3M A;  3TT4 A;  1MMP A;  1RMZ A;  2MZE A;  3Q2G A;  1WNI A;  1KUG A;  4WKE A;  3KMC A;  1ZXC A;  5I2Z A;  1SLM A;  3I7G A;  3RTT A;  1R54 A;  830C A;  5BPA A;  1BQQ M;  1YOU A;  1ZS0 A;  1XUR A;  1HFC A;  4ILW D;  3EHY A;  2OY2 A;  3E8R A;  5L7F A;  4A7B A;  5D1S A;  4IN9 A;  3UVC A;  3CKI A;  2OW0 A;  4CTH A;  4JA1 A;  2DDY A;  4L63 A;  1CGE A;  1SLN A;  4GR3 A;  2E2D A;  2XS3 A;  4GF1 A;  4HMA A;  1UTT A;  1QUA A;  1G12 A;  4L6T A;  3TSK A;  1MMB A;  2OXU A;  2JSD A;  1O0T A;  1USN A;  3EDI A;  1G05 A;  1XFV A;  1Y0V A;  4GWM A;  2JT6 A;  2PJT A;  2OY4 A;  2DDF A;  1AST A;  2K2G A;  2ERO A;  1XUD A;  2D1N A;  1BKC I;  1BUD A;  3U1R A;  2Y6D A;  1XUC A;  1QIB A;  456C A;  3LUN A;  3P1V A;  3B2Z A;  1BKC E;  3O2X A;  3LQ0 A;  1OS2 A;  3K7N A;  1ROS A;  2E3X A;  1OM6 A;  4XBH A;  1JJ9 A;  2OXW A;  3G5C A;  4A3W A;  1R1H A;  3MA2 A;  2POJ A;  1A85 A;  4PKU A;  4WF6 A;  5B5P A;  2W15 A;  1I73 A;  4PKV A;  3F19 A;  1SRP A;  1ZTQ A;  4XCT A;  3WV2 A;  3ZUK A;  2JT5 A;  1G9K A;  3L0T A;  1HV5 A;  4PKS A;  2CLT A;  1G4K A;  2O36 A;  2Y6C A;  2WOA A;  1XFY A;  1IAE A;  1Q3A A;  2CKI A;  4H76 A;  2N8R A;  3AYU A;  1KUI A;  5D2B A;  3KRY A;  1KBC A;  2K9C A;  2OZR A;  1JAO A;  4ON1 A;  2RJP A;  1G49 A;  2MLR A;  5B5O A;  2AIG P;  1A86 A;  1JKY A;  3AYK A;  2FV5 A;  4WKI A;  3KEC A;  1HFS A;  3KEK A;  3F1A A;  2J83 A;  3K7L A;  1B8Y A;  3LJG A;  4FXY P;  3HB2 P;  2A8H A;  2ERP A;  3B92 A;  4PKQ A;  3LIL A;  1CXV A;  2KRJ A;  4JP4 A;  2WO8 A;  1AF0 A;  1BM6 A;  1JK3 A;  2MLS A;  5CZM A;  1AYK A;  3HDB A;  1OMJ A;  2JNP A;  1FM1 A;  3HY7 A;  3LE9 A;  1KUF A;  4GR8 A;  3ZVS A;  4ZR5 A;  1CGF A;  3OHL A;  1L6J A;  3TVC A;  1I1I P;  2W14 A;  4XM7 A;  5LAB A;  4JQG A;  2W12 A;  1SMP A;  1YQY A;  1BUV M;  1PWU A;  1R1I A;  1CK7 A;  4Q1L A;  3SHI A;  2OVX A;  4GUY A;  2X3C A;  3DPF A;  1GXD A;  1QIC A;  2MZH A;  1CAQ A;  4AXQ A;  3N2V A;  3DL1 A;  1PWW A;  1H71 P;  1XFW A;  2OW9 A;  4FVL A;  2HU6 A;  3EHX A;  3LIR A;  1EB6 A;  1OM7 A;  3VTG A;  4R3V A;  3VI1 A;  1QJI A;  2W0D A;  2OW1 A;  3LMC A;  1JAN A;  1K7Q A;  3EDZ A;  3LJT A;  1GO8 P; 
#chains in the Genus database with same CATH topology
 5I4O A;  1UEA A;  1JAQ A;  5D1U A;  3EDH A;  3DTI A;  1FLS A;  2OI0 A;  3HYG A;  4PKR A;  5D1T A;  2SRT A;  4G9L A;  1ND1 A;  1OO9 A;  2X3B A;  3HDA P;  1DTH A;  1XM5 A;  4JIJ A;  2YB9 A;  1XFU A;  1PWP A;  4H30 A;  4DF9 A;  4H3X A;  4I35 A;  1GKD A;  3P24 A;  5JMY A;  4WZV A;  1PWV A;  1IAB A;  1ATL A;  4IJO A;  2QPJ A;  1OS9 A;  2J0T A;  4PKW A;  1OM8 A;  1KUK A;  2W13 A;  3RTS A;  1JIZ A;  3L0V A;  1EUB A;  966C A;  1UMT A;  5BOY A;  5CXA A;  2RJQ A;  3Q2H A;  1PWQ A;  3F16 A;  4PKT A;  3LIK A;  1MMR A;  4H49 A;  4H82 A;  3DWB A;  4DPE A;  1JIW P;  2D1O A;  4AUO A;  4QKZ A;  1GE7 A;  2USN A;  2X3A A;  4I03 A;  3LUM A;  5I0L A;  1QIA A;  3HBU P;  1Y93 A;  2WO9 A;  3BA0 A;  3GBO A;  1RM8 A;  3G42 A;  2FV9 A;  1R1J A;  3F17 A;  4GR0 A;  1D8M A;  3LJZ A;  2V4B A;  1MNC A;  2X7M A;  3LEA A;  2MZI A;  1YCM A;  3USN A;  1SU3 A;  2OXZ A;  1SAT A;  1BSW A;  3EWJ A;  4XM8 A;  1JH1 A;  1R55 A;  3O64 A;  3OHO A;  1C3I A;  4JPA A;  1FBL A;  1ZXV A;  2O3E A;  3KME A;  2DW2 A;  4HX3 A;  3LKA A;  1IAA A;  3LK8 A;  1KAP P;  3V96 B;  3DSL A;  1GKC A;  5D3C A;  3N2U A;  1BQO A;  2I47 A;  5CUH A;  3ZXH A;  1ZP5 A;  3HBV P;  1JAP A;  1BIW A;  1HY7 A;  1K7I A;  1XAX A;  1J7N A;  1B3D A;  3DPE A;  1BKC A;  2OVZ A;  2JIH A;  1HTD A;  3ELM A;  4XM6 A;  3AIG A;  4FXQ A;  1IAG A;  1GE6 A;  5BOT A;  1BZS A;  1UTZ A;  3DTE A;  1D5J A;  2L0R A;  1D7X A;  3KEJ A;  4H2E A;  3I7I A;  5L79 A;  2DW1 A;  1EAK A;  1YP1 A;  1HOV A;  2YIG A;  1S4B P;  4DD8 A;  3DNG A;  4IUW A;  4H84 A;  3TS4 A;  1I76 A;  1Y8J A;  3F18 A;  4DV8 A;  4AIG A;  1IAC A;  4GWN A;  1XFX A;  1C8T A;  3NX7 A;  1CQR A;  5I12 A;  4L19 A;  1DMT A;  4L7A A;  3B8Z A;  3LQB A;  1GO7 P;  1O0Q A;  1QJJ A;  1CIZ A;  4AYK A;  4FU4 A;  3KHI A;  3WV1 A;  4WK7 A;  3HY9 A;  5H8X A;  4GQL A;  1GE5 A;  1Z3J A;  2AYK A;  5I43 A;  3LGP A;  3F15 A;  1KUH A;  2XS4 A;  3KWV C;  3WV3 A;  1IAD A;  4H1Q A;  1TVI A;  2TCL A;  1AKL A;  4G0D A;  2OW2 A;  1D8F A;  4EFS A;  1K7G A;  5D7W A;  1UMS A;  1ZVX A;  2DW0 A;  2Z2D A;  1XFZ A;  4J4M A;  1MMQ A;  1C7K A;  1CGL A;  3EDG A;  2ERQ A;  5I3M A;  3TT4 A;  1MMP A;  1RMZ A;  2MZE A;  3Q2G A;  1WNI A;  1KUG A;  4WKE A;  3KMC A;  1ZXC A;  5I2Z A;  1SLM A;  3I7G A;  3RTT A;  1R54 A;  830C A;  5BPA A;  1BQQ M;  1YOU A;  1ZS0 A;  1XUR A;  1HFC A;  4ILW D;  3EHY A;  2OY2 A;  3E8R A;  5L7F A;  4A7B A;  5D1S A;  4IN9 A;  3UVC A;  3CKI A;  2OW0 A;  4CTH A;  4JA1 A;  2DDY A;  3DTK A;  4L63 A;  1CGE A;  1SLN A;  4GR3 A;  1OZ9 A;  2E2D A;  2XS3 A;  4GF1 A;  4HMA A;  1UTT A;  1QUA A;  1G12 A;  4L6T A;  3TSK A;  1MMB A;  2OXU A;  2JSD A;  1O0T A;  1USN A;  3EDI A;  1G05 A;  1XFV A;  1Y0V A;  4GWM A;  2JT6 A;  2PJT A;  2OY4 A;  2DDF A;  1AST A;  2K2G A;  2ERO A;  1XUD A;  2D1N A;  1BKC I;  1BUD A;  3U1R A;  2Y6D A;  1XUC A;  1QIB A;  456C A;  3LUN A;  3P1V A;  3B2Z A;  1BKC E;  3O2X A;  3LQ0 A;  1OS2 A;  3K7N A;  1ROS A;  2E3X A;  1OM6 A;  4XBH A;  1JJ9 A;  2OXW A;  3G5C A;  4A3W A;  1R1H A;  3MA2 A;  2POJ A;  1A85 A;  4PKU A;  4WF6 A;  5B5P A;  2W15 A;  1I73 A;  4PKV A;  3F19 A;  1SRP A;  1ZTQ A;  4XCT A;  3WV2 A;  3ZUK A;  2JT5 A;  1G9K A;  3L0T A;  1HV5 A;  4PKS A;  2CLT A;  1G4K A;  2O36 A;  2Y6C A;  2WOA A;  1XFY A;  1IAE A;  1Q3A A;  2CKI A;  4H76 A;  2N8R A;  3AYU A;  1KUI A;  5D2B A;  3KRY A;  1KBC A;  2K9C A;  2OZR A;  1JAO A;  4ON1 A;  2RJP A;  1G49 A;  2MLR A;  5B5O A;  2AIG P;  1A86 A;  1JKY A;  3AYK A;  2FV5 A;  4WKI A;  3KEC A;  1HFS A;  3KEK A;  3F1A A;  2J83 A;  3K7L A;  1B8Y A;  3LJG A;  4FXY P;  3HB2 P;  2A8H A;  2ERP A;  3B92 A;  4PKQ A;  3LIL A;  1CXV A;  2KRJ A;  4JP4 A;  2WO8 A;  1AF0 A;  1BM6 A;  2YUF A;  1JK3 A;  2MLS A;  5CZM A;  1AYK A;  3HDB A;  1OMJ A;  2JNP A;  1FM1 A;  3HY7 A;  3LE9 A;  1KUF A;  4GR8 A;  3ZVS A;  4ZR5 A;  1CGF A;  3OHL A;  1L6J A;  3TVC A;  1I1I P;  2W14 A;  4XM7 A;  5LAB A;  4JQG A;  2W12 A;  1SMP A;  1YQY A;  1BUV M;  1PWU A;  1R1I A;  1CK7 A;  4Q1L A;  3SHI A;  2OVX A;  4GUY A;  2X3C A;  3DPF A;  1GXD A;  1QIC A;  2MZH A;  1CAQ A;  4AXQ A;  3N2V A;  3DL1 A;  1PWW A;  1H71 P;  1XFW A;  2OW9 A;  4FVL A;  2HU6 A;  3EHX A;  3LIR A;  1EB6 A;  1OM7 A;  3VTG A;  4R3V A;  3VI1 A;  1QJI A;  2W0D A;  2OW1 A;  3LMC A;  1JAN A;  1K7Q A;  3EDZ A;  3LJT A;  1GO8 P; 
#chains in the Genus database with same CATH homology
 5I4O A;  1UEA A;  1JAQ A;  5D1U A;  3EDH A;  3DTI A;  1FLS A;  2OI0 A;  3HYG A;  4PKR A;  5D1T A;  2SRT A;  4G9L A;  1ND1 A;  1OO9 A;  2X3B A;  3HDA P;  1DTH A;  4JIJ A;  2YB9 A;  1XFU A;  1PWP A;  4H30 A;  4DF9 A;  4H3X A;  4I35 A;  1GKD A;  3P24 A;  5JMY A;  4WZV A;  1PWV A;  1IAB A;  1ATL A;  4IJO A;  2QPJ A;  1OS9 A;  2J0T A;  4PKW A;  1OM8 A;  1KUK A;  2W13 A;  3RTS A;  1JIZ A;  3L0V A;  1EUB A;  966C A;  1UMT A;  5BOY A;  5CXA A;  2RJQ A;  3Q2H A;  1PWQ A;  3F16 A;  4PKT A;  3LIK A;  1MMR A;  4H49 A;  4H82 A;  3DWB A;  4DPE A;  1JIW P;  2D1O A;  4AUO A;  4QKZ A;  1GE7 A;  2USN A;  2X3A A;  4I03 A;  3LUM A;  5I0L A;  1QIA A;  3HBU P;  1Y93 A;  2WO9 A;  3BA0 A;  3GBO A;  1RM8 A;  3G42 A;  2FV9 A;  1R1J A;  3F17 A;  4GR0 A;  1D8M A;  3LJZ A;  2V4B A;  1MNC A;  2X7M A;  3LEA A;  2MZI A;  1YCM A;  3USN A;  1SU3 A;  2OXZ A;  1SAT A;  1BSW A;  3EWJ A;  4XM8 A;  1JH1 A;  1R55 A;  3O64 A;  3OHO A;  1C3I A;  4JPA A;  1FBL A;  1ZXV A;  2O3E A;  3KME A;  2DW2 A;  4HX3 A;  3LKA A;  1IAA A;  3LK8 A;  1KAP P;  3V96 B;  3DSL A;  1GKC A;  5D3C A;  3N2U A;  1BQO A;  2I47 A;  5CUH A;  3ZXH A;  1ZP5 A;  3HBV P;  1JAP A;  1BIW A;  1HY7 A;  1K7I A;  1J7N A;  1B3D A;  3DPE A;  1BKC A;  2OVZ A;  2JIH A;  1HTD A;  3ELM A;  4XM6 A;  3AIG A;  4FXQ A;  1IAG A;  1GE6 A;  5BOT A;  1BZS A;  1UTZ A;  3DTE A;  1D5J A;  2L0R A;  1D7X A;  3KEJ A;  4H2E A;  3I7I A;  5L79 A;  2DW1 A;  1EAK A;  1YP1 A;  1HOV A;  2YIG A;  1S4B P;  4DD8 A;  3DNG A;  4IUW A;  4H84 A;  3TS4 A;  1I76 A;  1Y8J A;  3F18 A;  4DV8 A;  4AIG A;  1IAC A;  4GWN A;  1XFX A;  1C8T A;  3NX7 A;  1CQR A;  5I12 A;  4L19 A;  1DMT A;  4L7A A;  3B8Z A;  3LQB A;  1GO7 P;  1O0Q A;  1QJJ A;  1CIZ A;  4AYK A;  4FU4 A;  3KHI A;  3WV1 A;  4WK7 A;  3HY9 A;  5H8X A;  4GQL A;  1GE5 A;  1Z3J A;  2AYK A;  5I43 A;  3LGP A;  3F15 A;  1KUH A;  2XS4 A;  3KWV C;  3WV3 A;  1IAD A;  4H1Q A;  2TCL A;  1AKL A;  4G0D A;  2OW2 A;  1D8F A;  4EFS A;  1K7G A;  5D7W A;  1UMS A;  1ZVX A;  2DW0 A;  2Z2D A;  1XFZ A;  4J4M A;  1MMQ A;  1C7K A;  1CGL A;  3EDG A;  2ERQ A;  5I3M A;  3TT4 A;  1MMP A;  1RMZ A;  2MZE A;  3Q2G A;  1WNI A;  1KUG A;  4WKE A;  3KMC A;  1ZXC A;  5I2Z A;  1SLM A;  3I7G A;  3RTT A;  1R54 A;  830C A;  5BPA A;  1BQQ M;  1YOU A;  1ZS0 A;  1XUR A;  1HFC A;  4ILW D;  3EHY A;  2OY2 A;  3E8R A;  5L7F A;  4A7B A;  5D1S A;  4IN9 A;  3UVC A;  3CKI A;  2OW0 A;  4CTH A;  4JA1 A;  2DDY A;  3DTK A;  4L63 A;  1CGE A;  1SLN A;  4GR3 A;  2E2D A;  2XS3 A;  4GF1 A;  4HMA A;  1UTT A;  1QUA A;  1G12 A;  4L6T A;  3TSK A;  1MMB A;  2OXU A;  2JSD A;  1O0T A;  1USN A;  3EDI A;  1G05 A;  1XFV A;  1Y0V A;  4GWM A;  2JT6 A;  2PJT A;  2OY4 A;  2DDF A;  1AST A;  2K2G A;  2ERO A;  1XUD A;  2D1N A;  1BKC I;  1BUD A;  3U1R A;  2Y6D A;  1XUC A;  1QIB A;  456C A;  3LUN A;  3P1V A;  3B2Z A;  1BKC E;  3O2X A;  3LQ0 A;  1OS2 A;  3K7N A;  1ROS A;  2E3X A;  1OM6 A;  4XBH A;  1JJ9 A;  2OXW A;  3G5C A;  4A3W A;  1R1H A;  3MA2 A;  2POJ A;  1A85 A;  4PKU A;  4WF6 A;  5B5P A;  2W15 A;  1I73 A;  4PKV A;  3F19 A;  1SRP A;  1ZTQ A;  4XCT A;  3WV2 A;  3ZUK A;  2JT5 A;  1G9K A;  3L0T A;  1HV5 A;  4PKS A;  2CLT A;  1G4K A;  2O36 A;  2Y6C A;  2WOA A;  1XFY A;  1IAE A;  1Q3A A;  2CKI A;  4H76 A;  2N8R A;  3AYU A;  1KUI A;  5D2B A;  3KRY A;  1KBC A;  2K9C A;  2OZR A;  1JAO A;  4ON1 A;  2RJP A;  1G49 A;  2MLR A;  5B5O A;  2AIG P;  1A86 A;  1JKY A;  3AYK A;  2FV5 A;  4WKI A;  3KEC A;  1HFS A;  3KEK A;  3F1A A;  2J83 A;  3K7L A;  1B8Y A;  3LJG A;  4FXY P;  3HB2 P;  2A8H A;  2ERP A;  3B92 A;  4PKQ A;  3LIL A;  1CXV A;  2KRJ A;  4JP4 A;  2WO8 A;  1AF0 A;  1BM6 A;  2YUF A;  1JK3 A;  2MLS A;  5CZM A;  1AYK A;  3HDB A;  1OMJ A;  2JNP A;  1FM1 A;  3HY7 A;  3LE9 A;  1KUF A;  4GR8 A;  3ZVS A;  4ZR5 A;  1CGF A;  3OHL A;  1L6J A;  3TVC A;  1I1I P;  2W14 A;  4XM7 A;  5LAB A;  4JQG A;  2W12 A;  1SMP A;  1YQY A;  1BUV M;  1PWU A;  1R1I A;  1CK7 A;  4Q1L A;  3SHI A;  2OVX A;  4GUY A;  2X3C A;  3DPF A;  1GXD A;  1QIC A;  2MZH A;  1CAQ A;  4AXQ A;  3N2V A;  3DL1 A;  1PWW A;  1H71 P;  1XFW A;  2OW9 A;  4FVL A;  2HU6 A;  3EHX A;  3LIR A;  1EB6 A;  1OM7 A;  3VTG A;  4R3V A;  3VI1 A;  1QJI A;  2W0D A;  2OW1 A;  3LMC A;  1JAN A;  1K7Q A;  3EDZ A;  3LJT A;  1GO8 P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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