4WK7A

Crystal structure of human adamts-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-n-{[(4r)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
216
structure length
209
Chain Sequence
SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 71
structure length 209
sequence length 216
ec nomenclature ec 3.4.24.82: ADAMTS-4 endopeptidase.
pdb deposition date 2014-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4wk7A00
1EUBA 1KUHA 1OS2A 3LUNA 4DF9A 3GBOA 1CIZA 2MZEA 3MA2A 4XM6A 1O0TA 3LMCA 1HOVA 3WV2A 1GXDA 1GO7P 2W0DA 2YIGA 1D8FA 1DTHA 2OI0A 3O64A 2QPJA 3BA0A 1OMJA 3HY7A 3ZXHA 2X3BA 1HFCA 3HBVP 1I76A 2E2DA 3B92A 2N8RA 1Y8JA 2MZIA 4H76A 1XFUA 1AKLA 1B3DA 1C7KA 3KWVC 1CGLA 1D8MA 3LK8A 2DDFA 4A7BA 1QJIA 4AUOA 1SLMA 3KRYA 5H8XA 1CQRA 5I2ZA 1CXVA 1MMPA 2W12A 3AYUA 4PKQA 1J7NA 3KEKA 3N2UA 4DD8A 5B5PA 1KBCA 3VI1A 4ON1A 1BUVM 4R3VA 4FVLA 4IN9A 4EFSA 2HU6A 1BQQM 966CA 1OM8A 1YQYA 4HX3A 2OW0A 4I03A 4XM8A 1ZVXA 2OZRA 2WO9A 3LIKA 1R1HA 3K7LA 2Z2DA 3F18A 3AYKA 1SU3A 4GWMA 3TVCA 2OVZA 1PWUA 1JJ9A 2MLSA 5BOTA 2JT5A 2X3CA 4PKWA 2O36A 3E8RA 3LUMA 4H2EA 4PKVA 4GR0A 4H30A 1Z3JA 3Q2HA 1JANA 5BOYA 5L7FA 1OS9A 1YOUA 3WV1A 3K7NA 1PWVA 1QICA 3B2ZA 1K7IA 2Y6CA 1G49A 4ZR5A 1WNIA 2E3XA 2EROA 3EDGA 3F19A 1QIBA 1G05A 1HFSA 4WZVA 5B5OA 1R54A 1K7GA 2K2GA 1I1IP 4XBHA 4L63A 2L0RA 3F15A 3LKAA 4PKTA 4H1QA 3Q2GA 5LABA 1JAQA 2XS4A 1K7QA 1SRPA 1HTDA 3KHIA 3LIRA 3LQBA 2Y6DA 2CLTA 4GUYA 3TSKA 3DNGA 2ERQA 3USNA 1A85A 1BQOA 1IAEA 1Y0VA 3DWBA 3OHOA 1D5JA 2POJA 4AXQA 3G42A 4J4MA 1XUCA 3LGPA 3RTSA 2RJPA 1IAGA 2OY4A 3V96B 1ZXCA 1SLNA 3EHYA 1ND1A 1G12A 4WKEA 1AYKA 1BKCI 1XFVA 1CGEA 4FXYP 456CA 5I0LA 1DMTA 1IABA 1O0QA 3HBUP 3DPFA 2W14A 4JP4A 1R1IA 5D1TA 4DV8A 3I7IA 1KAPP 1GE5A 1UTTA 3HDAP 4G9LA 1QJJA 1MMRA 4XCTA 3OHLA 3L0VA 1G9KA 1JK3A 3B8ZA 3F16A 4GF1A 2J0TA 1CAQA 4WKIA 3I7GA 3O2XA 1ZP5A 1MMBA 2O3EA 3LE9A 1FBLA 2D1OA 3EWJA 3G5CA 1KUFA 3KECA 1OO9A 2DW1A 3TS4A 3EDIA 3EHXA 4JPAA 1B8YA 4JIJA 1HV5A 1GKDA 2DW0A 3KMCA 3P24A 4CTHA 4GR8A 1JAPA 4FU4A 1GO8P 1D7XA 3ZVSA 5I43A 1KUIA 2OY2A 1XURA 2W13A 1FM1A 1XUDA 4I35A 1PWWA 2OW2A 2MLRA 1PWPA 3LJTA 4PKUA 2OXUA 1UEAA 1JAOA 1OM6A 5I3MA 4FXQA 2AYKA 1CK7A 1OM7A 2OXZA 1GKCA 5I4OA 4AIGA 1RM8A 1RMZA 1UMSA 1BKCE 4GQLA 1IADA 2D1NA 5D7WA 3P1VA 1ASTA 1JIZA 2JNPA 2SRTA 2OXWA 4HMAA 1BZSA 1ROSA 2DW2A 4H49A 3AIGA 1PWQA 2MZHA 5L79A 3N2VA 2JIHA 3HYGA 3WV3A 4PKRA 1KUKA 5D3CA 2JSDA 3LJGA 4AYKA 1GE6A 2A8HA 2X3AA 2WOAA 3VTGA 3KEJA 5CXAA 1H71P 2ERPA 830CA 5D2BA 4H3XA 3ELMA 2K9CA 4H84A 4XM7A 3LEAA 4Q1LA 1XFXA 1EAKA 1I73A 1SMPA 2KRJA 1S4BP 3TT4A 3LJZA 4A3WA 1EB6A 1XFYA 4ILWD 1G4KA 3HB2P 4GR3A 2X7MA 4WK7A 1HY7A 3U1RA 1CGFA 4WF6A 1C3IA 1QUAA 4PKSA 2W15A 3KMEA 2XS3A 2JT6A 5CUHA 2FV9A 3RTTA 1Y93A 1IACA 4GWNA 1ZTQA 2V4BA 3F17A 3NX7A 4IUWA 1USNA 2J83A 1C8TA 5I12A 5JMYA 5CZMA 4G0DA 3EDZA 1ATLA 3HY9A 2I47A 3SHIA 1AF0A 3CKIA 3HDBA 1A86A 4IJOA 1YCMA 2CKIA 1QIAA 2DDYA 2OW1A 1YP1A 3DPEA 1BKCA 4QKZA 4H82A 1SATA 1ZXVA 1BM6A 5D1SA 3LILA 3DSLA 3ZUKA 2AIGP 3L0TA 4JA1A 2USNA 1XFWA 1JH1A 3EDHA 3LQ0A 5D1UA 2YB9A 2FV5A 1R55A 1XFZA 1MNCA 1ZS0A 1FLSA 4L6TA 1Q3AA 2OW9A 3F1AA 2RJQA 4DPEA 2TCLA 5BPAA 1JIWP 1MMQA 1JKYA 3UVCA 1L6JA 2OVXA 4JQGA 1BSWA 4L19A 1BUDA 1R1JA 1UTZA 2PJTA 1IAAA 2WO8A 1BIWA 1UMTA 1KUGA 1GE7A 3DL1A
chains in the Genus database with same CATH superfamily
1EUBA 1KUHA 1OS2A 3LUNA 4DF9A 3GBOA 1CIZA 2MZEA 3MA2A 4XM6A 1O0TA 3LMCA 1HOVA 3WV2A 1GXDA 1GO7P 2W0DA 2YIGA 1D8FA 1DTHA 2OI0A 3O64A 2QPJA 3BA0A 1OMJA 3HY7A 3ZXHA 2X3BA 1HFCA 3HBVP 1I76A 2E2DA 3B92A 2N8RA 1Y8JA 2MZIA 4H76A 1XFUA 1AKLA 1B3DA 1C7KA 3KWVC 1CGLA 1D8MA 3LK8A 2DDFA 4A7BA 1QJIA 4AUOA 1SLMA 3KRYA 5H8XA 1CQRA 5I2ZA 1CXVA 1MMPA 2W12A 3AYUA 4PKQA 1J7NA 3KEKA 3N2UA 4DD8A 5B5PA 1KBCA 3VI1A 4ON1A 1BUVM 4R3VA 4FVLA 4IN9A 4EFSA 2HU6A 1BQQM 966CA 1OM8A 1YQYA 4HX3A 2OW0A 4I03A 4XM8A 1ZVXA 2OZRA 2WO9A 3LIKA 1R1HA 3K7LA 2Z2DA 3F18A 3AYKA 1SU3A 4GWMA 3TVCA 2OVZA 1PWUA 1JJ9A 2MLSA 5BOTA 2JT5A 2X3CA 4PKWA 2O36A 3E8RA 3LUMA 4H2EA 4PKVA 4GR0A 4L7AA 4H30A 1Z3JA 2YUFA 3Q2HA 1JANA 5BOYA 5L7FA 1OS9A 1YOUA 3WV1A 3K7NA 1PWVA 1QICA 3B2ZA 1K7IA 2Y6CA 1G49A 4ZR5A 1WNIA 2E3XA 2EROA 3EDGA 3F19A 1QIBA 1G05A 1HFSA 4WZVA 5B5OA 1R54A 1K7GA 2K2GA 1I1IP 4XBHA 4L63A 2L0RA 3F15A 3LKAA 4PKTA 4H1QA 3Q2GA 5LABA 1JAQA 2XS4A 1K7QA 1SRPA 1HTDA 3KHIA 3LIRA 3LQBA 2Y6DA 2CLTA 4GUYA 3TSKA 3DNGA 2ERQA 3USNA 1A85A 1BQOA 1IAEA 1Y0VA 3DWBA 3OHOA 1D5JA 2POJA 4AXQA 3G42A 4J4MA 1XUCA 3LGPA 3RTSA 2RJPA 1IAGA 2OY4A 3V96B 1ZXCA 1SLNA 3EHYA 1ND1A 1G12A 4WKEA 1AYKA 1BKCI 1XFVA 1CGEA 4FXYP 456CA 5I0LA 1DMTA 1IABA 1O0QA 3HBUP 3DPFA 2W14A 4JP4A 1R1IA 5D1TA 4DV8A 3I7IA 1KAPP 1GE5A 1UTTA 3HDAP 4G9LA 1QJJA 1MMRA 4XCTA 3OHLA 3L0VA 1G9KA 1JK3A 3B8ZA 3F16A 4GF1A 2J0TA 1CAQA 4WKIA 3I7GA 3O2XA 1ZP5A 1MMBA 2O3EA 1XM5A 3LE9A 1FBLA 2D1OA 3EWJA 3G5CA 1KUFA 3KECA 1OO9A 2DW1A 3TS4A 3EDIA 3EHXA 4JPAA 1B8YA 4JIJA 1HV5A 1GKDA 2DW0A 3KMCA 3P24A 4CTHA 4GR8A 1JAPA 4FU4A 1GO8P 1D7XA 3ZVSA 5I43A 1KUIA 2OY2A 1XURA 2W13A 1FM1A 1XUDA 3DTEA 4I35A 1PWWA 2OW2A 2MLRA 1PWPA 3LJTA 4PKUA 2OXUA 1UEAA 1JAOA 1OM6A 5I3MA 4FXQA 2AYKA 1CK7A 1OZ9A 1OM7A 2OXZA 1GKCA 5I4OA 4AIGA 1RM8A 1RMZA 1UMSA 1BKCE 4GQLA 1IADA 2D1NA 5D7WA 3P1VA 1ASTA 1JIZA 2JNPA 2SRTA 2OXWA 4HMAA 1BZSA 1ROSA 2DW2A 4H49A 3AIGA 1PWQA 2MZHA 5L79A 3N2VA 2JIHA 3HYGA 3WV3A 4PKRA 1KUKA 5D3CA 2JSDA 3LJGA 4AYKA 1GE6A 3DTIA 2A8HA 2X3AA 2WOAA 3VTGA 3KEJA 5CXAA 1H71P 2ERPA 830CA 5D2BA 4H3XA 3ELMA 2K9CA 4H84A 4XM7A 3LEAA 4Q1LA 1XFXA 1EAKA 1I73A 1SMPA 2KRJA 1S4BP 3TT4A 3LJZA 4A3WA 1EB6A 1XFYA 4ILWD 1G4KA 3HB2P 4GR3A 2X7MA 4WK7A 1HY7A 3U1RA 1CGFA 4WF6A 1C3IA 1QUAA 4PKSA 2W15A 3KMEA 2XS3A 2JT6A 5CUHA 2FV9A 3RTTA 1Y93A 1IACA 4GWNA 1ZTQA 2V4BA 1XAXA 3F17A 3NX7A 4IUWA 1USNA 2J83A 1C8TA 5I12A 5JMYA 5CZMA 4G0DA 3EDZA 1ATLA 3HY9A 2I47A 3SHIA 1AF0A 3CKIA 3HDBA 1A86A 4IJOA 1YCMA 2CKIA 1QIAA 2DDYA 2OW1A 1YP1A 3DPEA 1BKCA 4QKZA 4H82A 1SATA 1ZXVA 1BM6A 5D1SA 3LILA 3DSLA 3ZUKA 2AIGP 3L0TA 4JA1A 2USNA 1XFWA 1JH1A 3EDHA 1TVIA 3LQ0A 5D1UA 2YB9A 2FV5A 1R55A 1XFZA 1MNCA 1ZS0A 1FLSA 3DTKA 4L6TA 1Q3AA 2OW9A 3F1AA 2RJQA 4DPEA 2TCLA 5BPAA 1JIWP 1MMQA 1JKYA 3UVCA 1L6JA 2OVXA 4JQGA 1BSWA 4L19A 1BUDA 1R1JA 1UTZA 2PJTA 1IAAA 2WO8A 1BIWA 1UMTA 1KUGA 1GE7A 3DL1A
chains in the Genus database with same CATH topology
1EUBA 1KUHA 1OS2A 3LUNA 4DF9A 3GBOA 1CIZA 2MZEA 3MA2A 4XM6A 1O0TA 3LMCA 1HOVA 3WV2A 1GXDA 1GO7P 2W0DA 2YIGA 1D8FA 1DTHA 2OI0A 3O64A 2QPJA 3BA0A 1OMJA 3HY7A 3ZXHA 2X3BA 1HFCA 3HBVP 1I76A 2E2DA 3B92A 2N8RA 1Y8JA 2MZIA 4H76A 1XFUA 1AKLA 1B3DA 1C7KA 3KWVC 1CGLA 1D8MA 3LK8A 2DDFA 4A7BA 1QJIA 4AUOA 1SLMA 3KRYA 5H8XA 1CQRA 5I2ZA 1CXVA 1MMPA 2W12A 3AYUA 4PKQA 1J7NA 3KEKA 3N2UA 4DD8A 5B5PA 1KBCA 3VI1A 4ON1A 1BUVM 4R3VA 4FVLA 4IN9A 4EFSA 2HU6A 1BQQM 966CA 1OM8A 1YQYA 4HX3A 2OW0A 4I03A 4XM8A 1ZVXA 2OZRA 2WO9A 3LIKA 1R1HA 3K7LA 2Z2DA 3F18A 3AYKA 1SU3A 4GWMA 3TVCA 2OVZA 1PWUA 1JJ9A 2MLSA 5BOTA 2JT5A 2X3CA 4PKWA 2O36A 3E8RA 3LUMA 4H2EA 4PKVA 4GR0A 4L7AA 4H30A 1Z3JA 2YUFA 3Q2HA 1JANA 5BOYA 5L7FA 1OS9A 1YOUA 3WV1A 3K7NA 1PWVA 1QICA 3B2ZA 1K7IA 2Y6CA 1G49A 4ZR5A 1WNIA 2E3XA 2EROA 3EDGA 3F19A 1QIBA 1G05A 1HFSA 4WZVA 5B5OA 1R54A 1K7GA 2K2GA 1I1IP 4XBHA 4L63A 2L0RA 3F15A 3LKAA 4PKTA 4H1QA 3Q2GA 5LABA 1JAQA 2XS4A 1K7QA 1SRPA 1HTDA 3KHIA 3LIRA 3LQBA 2Y6DA 2CLTA 4GUYA 3TSKA 3DNGA 2ERQA 3USNA 1A85A 1BQOA 1IAEA 1Y0VA 3DWBA 3OHOA 1D5JA 2POJA 4AXQA 3G42A 4J4MA 1XUCA 3LGPA 3RTSA 2RJPA 1IAGA 2OY4A 3V96B 1ZXCA 1SLNA 3EHYA 1ND1A 1G12A 4WKEA 1AYKA 1BKCI 1XFVA 1CGEA 4FXYP 456CA 5I0LA 1DMTA 1IABA 1O0QA 3HBUP 3DPFA 2W14A 4JP4A 1R1IA 5D1TA 4DV8A 3I7IA 1KAPP 1GE5A 1UTTA 3HDAP 4G9LA 1QJJA 1MMRA 4XCTA 3OHLA 3L0VA 1G9KA 1JK3A 3B8ZA 3F16A 4GF1A 2J0TA 1CAQA 4WKIA 3I7GA 3O2XA 1ZP5A 1MMBA 2O3EA 3LE9A 1FBLA 2D1OA 3EWJA 3G5CA 1KUFA 3KECA 1OO9A 2DW1A 3TS4A 3EDIA 3EHXA 4JPAA 1B8YA 4JIJA 1HV5A 1GKDA 2DW0A 3KMCA 3P24A 4CTHA 4GR8A 1JAPA 4FU4A 1GO8P 1D7XA 3ZVSA 5I43A 1KUIA 2OY2A 1XURA 2W13A 1FM1A 1XUDA 3DTEA 4I35A 1PWWA 2OW2A 2MLRA 1PWPA 3LJTA 4PKUA 2OXUA 1UEAA 1JAOA 1OM6A 5I3MA 4FXQA 2AYKA 1CK7A 1OM7A 2OXZA 1GKCA 5I4OA 4AIGA 1RM8A 1RMZA 1UMSA 1BKCE 4GQLA 1IADA 2D1NA 5D7WA 3P1VA 1ASTA 1JIZA 2JNPA 2SRTA 2OXWA 4HMAA 1BZSA 1ROSA 2DW2A 4H49A 3AIGA 1PWQA 2MZHA 5L79A 3N2VA 2JIHA 3HYGA 3WV3A 4PKRA 1KUKA 5D3CA 2JSDA 3LJGA 4AYKA 1GE6A 3DTIA 2A8HA 2X3AA 2WOAA 3VTGA 3KEJA 5CXAA 1H71P 2ERPA 830CA 5D2BA 4H3XA 3ELMA 2K9CA 4H84A 4XM7A 3LEAA 4Q1LA 1XFXA 1EAKA 1I73A 1SMPA 2KRJA 1S4BP 3TT4A 3LJZA 4A3WA 1EB6A 1XFYA 4ILWD 1G4KA 3HB2P 4GR3A 2X7MA 4WK7A 1HY7A 3U1RA 1CGFA 4WF6A 1C3IA 1QUAA 4PKSA 2W15A 3KMEA 2XS3A 2JT6A 5CUHA 2FV9A 3RTTA 1Y93A 1IACA 4GWNA 1ZTQA 2V4BA 3F17A 3NX7A 4IUWA 1USNA 2J83A 1C8TA 5I12A 5JMYA 5CZMA 4G0DA 3EDZA 1ATLA 3HY9A 2I47A 3SHIA 1AF0A 3CKIA 3HDBA 1A86A 4IJOA 1YCMA 2CKIA 1QIAA 2DDYA 2OW1A 1YP1A 3DPEA 1BKCA 4QKZA 4H82A 1SATA 1ZXVA 1BM6A 5D1SA 3LILA 3DSLA 3ZUKA 2AIGP 3L0TA 4JA1A 2USNA 1XFWA 1JH1A 3EDHA 3LQ0A 5D1UA 2YB9A 2FV5A 1R55A 1XFZA 1MNCA 1ZS0A 1FLSA 3DTKA 4L6TA 1Q3AA 2OW9A 3F1AA 2RJQA 4DPEA 2TCLA 5BPAA 1JIWP 1MMQA 1JKYA 3UVCA 1L6JA 2OVXA 4JQGA 1BSWA 4L19A 1BUDA 1R1JA 1UTZA 2PJTA 1IAAA 2WO8A 1BIWA 1UMTA 1KUGA 1GE7A 3DL1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EUB A;  1KUH A;  1OS2 A;  3LUN A;  4DF9 A;  3GBO A;  1CIZ A;  2MZE A;  3MA2 A;  4XM6 A;  1O0T A;  3LMC A;  1HOV A;  3WV2 A;  1GXD A;  1GO7 P;  2W0D A;  2YIG A;  1D8F A;  1DTH A;  2OI0 A;  3O64 A;  2QPJ A;  3BA0 A;  1OMJ A;  3HY7 A;  3ZXH A;  2X3B A;  1HFC A;  3HBV P;  1I76 A;  2E2D A;  3B92 A;  2N8R A;  1Y8J A;  2MZI A;  4H76 A;  1XFU A;  1AKL A;  1B3D A;  1C7K A;  3KWV C;  1CGL A;  1D8M A;  3LK8 A;  2DDF A;  4A7B A;  1QJI A;  4AUO A;  1SLM A;  3KRY A;  5H8X A;  1CQR A;  5I2Z A;  1CXV A;  1MMP A;  2W12 A;  3AYU A;  4PKQ A;  1J7N A;  3KEK A;  3N2U A;  4DD8 A;  5B5P A;  1KBC A;  3VI1 A;  4ON1 A;  1BUV M;  4R3V A;  4FVL A;  4IN9 A;  4EFS A;  2HU6 A;  1BQQ M;  966C A;  1OM8 A;  1YQY A;  4HX3 A;  2OW0 A;  4I03 A;  4XM8 A;  1ZVX A;  2OZR A;  2WO9 A;  3LIK A;  1R1H A;  3K7L A;  2Z2D A;  3F18 A;  3AYK A;  1SU3 A;  4GWM A;  3TVC A;  2OVZ A;  1PWU A;  1JJ9 A;  2MLS A;  5BOT A;  2JT5 A;  2X3C A;  4PKW A;  2O36 A;  3E8R A;  3LUM A;  4H2E A;  4PKV A;  4GR0 A;  4H30 A;  1Z3J A;  3Q2H A;  1JAN A;  5BOY A;  5L7F A;  1OS9 A;  1YOU A;  3WV1 A;  3K7N A;  1PWV A;  1QIC A;  3B2Z A;  1K7I A;  2Y6C A;  1G49 A;  4ZR5 A;  1WNI A;  2E3X A;  2ERO A;  3EDG A;  3F19 A;  1QIB A;  1G05 A;  1HFS A;  4WZV A;  5B5O A;  1R54 A;  1K7G A;  2K2G A;  1I1I P;  4XBH A;  4L63 A;  2L0R A;  3F15 A;  3LKA A;  4PKT A;  4H1Q A;  3Q2G A;  5LAB A;  1JAQ A;  2XS4 A;  1K7Q A;  1SRP A;  1HTD A;  3KHI A;  3LIR A;  3LQB A;  2Y6D A;  2CLT A;  4GUY A;  3TSK A;  3DNG A;  2ERQ A;  3USN A;  1A85 A;  1BQO A;  1IAE A;  1Y0V A;  3DWB A;  3OHO A;  1D5J A;  2POJ A;  4AXQ A;  3G42 A;  4J4M A;  1XUC A;  3LGP A;  3RTS A;  2RJP A;  1IAG A;  2OY4 A;  3V96 B;  1ZXC A;  1SLN A;  3EHY A;  1ND1 A;  1G12 A;  4WKE A;  1AYK A;  1BKC I;  1XFV A;  1CGE A;  4FXY P;  456C A;  5I0L A;  1DMT A;  1IAB A;  1O0Q A;  3HBU P;  3DPF A;  2W14 A;  4JP4 A;  1R1I A;  5D1T A;  4DV8 A;  3I7I A;  1KAP P;  1GE5 A;  1UTT A;  3HDA P;  4G9L A;  1QJJ A;  1MMR A;  4XCT A;  3OHL A;  3L0V A;  1G9K A;  1JK3 A;  3B8Z A;  3F16 A;  4GF1 A;  2J0T A;  1CAQ A;  4WKI A;  3I7G A;  3O2X A;  1ZP5 A;  1MMB A;  2O3E A;  3LE9 A;  1FBL A;  2D1O A;  3EWJ A;  3G5C A;  1KUF A;  3KEC A;  1OO9 A;  2DW1 A;  3TS4 A;  3EDI A;  3EHX A;  4JPA A;  1B8Y A;  4JIJ A;  1HV5 A;  1GKD A;  2DW0 A;  3KMC A;  3P24 A;  4CTH A;  4GR8 A;  1JAP A;  4FU4 A;  1GO8 P;  1D7X A;  3ZVS A;  5I43 A;  1KUI A;  2OY2 A;  1XUR A;  2W13 A;  1FM1 A;  1XUD A;  4I35 A;  1PWW A;  2OW2 A;  2MLR A;  1PWP A;  3LJT A;  4PKU A;  2OXU A;  1UEA A;  1JAO A;  1OM6 A;  5I3M A;  4FXQ A;  2AYK A;  1CK7 A;  1OM7 A;  2OXZ A;  1GKC A;  5I4O A;  4AIG A;  1RM8 A;  1RMZ A;  1UMS A;  1BKC E;  4GQL A;  1IAD A;  2D1N A;  5D7W A;  3P1V A;  1AST A;  1JIZ A;  2JNP A;  2SRT A;  2OXW A;  4HMA A;  1BZS A;  1ROS A;  2DW2 A;  4H49 A;  3AIG A;  1PWQ A;  2MZH A;  5L79 A;  3N2V A;  2JIH A;  3HYG A;  3WV3 A;  4PKR A;  1KUK A;  5D3C A;  2JSD A;  3LJG A;  4AYK A;  1GE6 A;  2A8H A;  2X3A A;  2WOA A;  3VTG A;  3KEJ A;  5CXA A;  1H71 P;  2ERP A;  830C A;  5D2B A;  4H3X A;  3ELM A;  2K9C A;  4H84 A;  4XM7 A;  3LEA A;  4Q1L A;  1XFX A;  1EAK A;  1I73 A;  1SMP A;  2KRJ A;  1S4B P;  3TT4 A;  3LJZ A;  4A3W A;  1EB6 A;  1XFY A;  4ILW D;  1G4K A;  3HB2 P;  4GR3 A;  2X7M A;  4WK7 A;  1HY7 A;  3U1R A;  1CGF A;  4WF6 A;  1C3I A;  1QUA A;  4PKS A;  2W15 A;  3KME A;  2XS3 A;  2JT6 A;  5CUH A;  2FV9 A;  3RTT A;  1Y93 A;  1IAC A;  4GWN A;  1ZTQ A;  2V4B A;  3F17 A;  3NX7 A;  4IUW A;  1USN A;  2J83 A;  1C8T A;  5I12 A;  5JMY A;  5CZM A;  4G0D A;  3EDZ A;  1ATL A;  3HY9 A;  2I47 A;  3SHI A;  1AF0 A;  3CKI A;  3HDB A;  1A86 A;  4IJO A;  1YCM A;  2CKI A;  1QIA A;  2DDY A;  2OW1 A;  1YP1 A;  3DPE A;  1BKC A;  4QKZ A;  4H82 A;  1SAT A;  1ZXV A;  1BM6 A;  5D1S A;  3LIL A;  3DSL A;  3ZUK A;  2AIG P;  3L0T A;  4JA1 A;  2USN A;  1XFW A;  1JH1 A;  3EDH A;  3LQ0 A;  5D1U A;  2YB9 A;  2FV5 A;  1R55 A;  1XFZ A;  1MNC A;  1ZS0 A;  1FLS A;  4L6T A;  1Q3A A;  2OW9 A;  3F1A A;  2RJQ A;  4DPE A;  2TCL A;  5BPA A;  1JIW P;  1MMQ A;  1JKY A;  3UVC A;  1L6J A;  2OVX A;  4JQG A;  1BSW A;  4L19 A;  1BUD A;  1R1J A;  1UTZ A;  2PJT A;  1IAA A;  2WO8 A;  1BIW A;  1UMT A;  1KUG A;  1GE7 A;  3DL1 A; 
#chains in the Genus database with same CATH topology
 1EUB A;  1KUH A;  1OS2 A;  3LUN A;  4DF9 A;  3GBO A;  1CIZ A;  2MZE A;  3MA2 A;  4XM6 A;  1O0T A;  3LMC A;  1HOV A;  3WV2 A;  1GXD A;  1GO7 P;  2W0D A;  2YIG A;  1D8F A;  1DTH A;  2OI0 A;  3O64 A;  2QPJ A;  3BA0 A;  1OMJ A;  3HY7 A;  3ZXH A;  2X3B A;  1HFC A;  3HBV P;  1I76 A;  2E2D A;  3B92 A;  2N8R A;  1Y8J A;  2MZI A;  4H76 A;  1XFU A;  1AKL A;  1B3D A;  1C7K A;  3KWV C;  1CGL A;  1D8M A;  3LK8 A;  2DDF A;  4A7B A;  1QJI A;  4AUO A;  1SLM A;  3KRY A;  5H8X A;  1CQR A;  5I2Z A;  1CXV A;  1MMP A;  2W12 A;  3AYU A;  4PKQ A;  1J7N A;  3KEK A;  3N2U A;  4DD8 A;  5B5P A;  1KBC A;  3VI1 A;  4ON1 A;  1BUV M;  4R3V A;  4FVL A;  4IN9 A;  4EFS A;  2HU6 A;  1BQQ M;  966C A;  1OM8 A;  1YQY A;  4HX3 A;  2OW0 A;  4I03 A;  4XM8 A;  1ZVX A;  2OZR A;  2WO9 A;  3LIK A;  1R1H A;  3K7L A;  2Z2D A;  3F18 A;  3AYK A;  1SU3 A;  4GWM A;  3TVC A;  2OVZ A;  1PWU A;  1JJ9 A;  2MLS A;  5BOT A;  2JT5 A;  2X3C A;  4PKW A;  2O36 A;  3E8R A;  3LUM A;  4H2E A;  4PKV A;  4GR0 A;  4L7A A;  4H30 A;  1Z3J A;  2YUF A;  3Q2H A;  1JAN A;  5BOY A;  5L7F A;  1OS9 A;  1YOU A;  3WV1 A;  3K7N A;  1PWV A;  1QIC A;  3B2Z A;  1K7I A;  2Y6C A;  1G49 A;  4ZR5 A;  1WNI A;  2E3X A;  2ERO A;  3EDG A;  3F19 A;  1QIB A;  1G05 A;  1HFS A;  4WZV A;  5B5O A;  1R54 A;  1K7G A;  2K2G A;  1I1I P;  4XBH A;  4L63 A;  2L0R A;  3F15 A;  3LKA A;  4PKT A;  4H1Q A;  3Q2G A;  5LAB A;  1JAQ A;  2XS4 A;  1K7Q A;  1SRP A;  1HTD A;  3KHI A;  3LIR A;  3LQB A;  2Y6D A;  2CLT A;  4GUY A;  3TSK A;  3DNG A;  2ERQ A;  3USN A;  1A85 A;  1BQO A;  1IAE A;  1Y0V A;  3DWB A;  3OHO A;  1D5J A;  2POJ A;  4AXQ A;  3G42 A;  4J4M A;  1XUC A;  3LGP A;  3RTS A;  2RJP A;  1IAG A;  2OY4 A;  3V96 B;  1ZXC A;  1SLN A;  3EHY A;  1ND1 A;  1G12 A;  4WKE A;  1AYK A;  1BKC I;  1XFV A;  1CGE A;  4FXY P;  456C A;  5I0L A;  1DMT A;  1IAB A;  1O0Q A;  3HBU P;  3DPF A;  2W14 A;  4JP4 A;  1R1I A;  5D1T A;  4DV8 A;  3I7I A;  1KAP P;  1GE5 A;  1UTT A;  3HDA P;  4G9L A;  1QJJ A;  1MMR A;  4XCT A;  3OHL A;  3L0V A;  1G9K A;  1JK3 A;  3B8Z A;  3F16 A;  4GF1 A;  2J0T A;  1CAQ A;  4WKI A;  3I7G A;  3O2X A;  1ZP5 A;  1MMB A;  2O3E A;  1XM5 A;  3LE9 A;  1FBL A;  2D1O A;  3EWJ A;  3G5C A;  1KUF A;  3KEC A;  1OO9 A;  2DW1 A;  3TS4 A;  3EDI A;  3EHX A;  4JPA A;  1B8Y A;  4JIJ A;  1HV5 A;  1GKD A;  2DW0 A;  3KMC A;  3P24 A;  4CTH A;  4GR8 A;  1JAP A;  4FU4 A;  1GO8 P;  1D7X A;  3ZVS A;  5I43 A;  1KUI A;  2OY2 A;  1XUR A;  2W13 A;  1FM1 A;  1XUD A;  3DTE A;  4I35 A;  1PWW A;  2OW2 A;  2MLR A;  1PWP A;  3LJT A;  4PKU A;  2OXU A;  1UEA A;  1JAO A;  1OM6 A;  5I3M A;  4FXQ A;  2AYK A;  1CK7 A;  1OZ9 A;  1OM7 A;  2OXZ A;  1GKC A;  5I4O A;  4AIG A;  1RM8 A;  1RMZ A;  1UMS A;  1BKC E;  4GQL A;  1IAD A;  2D1N A;  5D7W A;  3P1V A;  1AST A;  1JIZ A;  2JNP A;  2SRT A;  2OXW A;  4HMA A;  1BZS A;  1ROS A;  2DW2 A;  4H49 A;  3AIG A;  1PWQ A;  2MZH A;  5L79 A;  3N2V A;  2JIH A;  3HYG A;  3WV3 A;  4PKR A;  1KUK A;  5D3C A;  2JSD A;  3LJG A;  4AYK A;  1GE6 A;  3DTI A;  2A8H A;  2X3A A;  2WOA A;  3VTG A;  3KEJ A;  5CXA A;  1H71 P;  2ERP A;  830C A;  5D2B A;  4H3X A;  3ELM A;  2K9C A;  4H84 A;  4XM7 A;  3LEA A;  4Q1L A;  1XFX A;  1EAK A;  1I73 A;  1SMP A;  2KRJ A;  1S4B P;  3TT4 A;  3LJZ A;  4A3W A;  1EB6 A;  1XFY A;  4ILW D;  1G4K A;  3HB2 P;  4GR3 A;  2X7M A;  4WK7 A;  1HY7 A;  3U1R A;  1CGF A;  4WF6 A;  1C3I A;  1QUA A;  4PKS A;  2W15 A;  3KME A;  2XS3 A;  2JT6 A;  5CUH A;  2FV9 A;  3RTT A;  1Y93 A;  1IAC A;  4GWN A;  1ZTQ A;  2V4B A;  1XAX A;  3F17 A;  3NX7 A;  4IUW A;  1USN A;  2J83 A;  1C8T A;  5I12 A;  5JMY A;  5CZM A;  4G0D A;  3EDZ A;  1ATL A;  3HY9 A;  2I47 A;  3SHI A;  1AF0 A;  3CKI A;  3HDB A;  1A86 A;  4IJO A;  1YCM A;  2CKI A;  1QIA A;  2DDY A;  2OW1 A;  1YP1 A;  3DPE A;  1BKC A;  4QKZ A;  4H82 A;  1SAT A;  1ZXV A;  1BM6 A;  5D1S A;  3LIL A;  3DSL A;  3ZUK A;  2AIG P;  3L0T A;  4JA1 A;  2USN A;  1XFW A;  1JH1 A;  3EDH A;  1TVI A;  3LQ0 A;  5D1U A;  2YB9 A;  2FV5 A;  1R55 A;  1XFZ A;  1MNC A;  1ZS0 A;  1FLS A;  3DTK A;  4L6T A;  1Q3A A;  2OW9 A;  3F1A A;  2RJQ A;  4DPE A;  2TCL A;  5BPA A;  1JIW P;  1MMQ A;  1JKY A;  3UVC A;  1L6J A;  2OVX A;  4JQG A;  1BSW A;  4L19 A;  1BUD A;  1R1J A;  1UTZ A;  2PJT A;  1IAA A;  2WO8 A;  1BIW A;  1UMT A;  1KUG A;  1GE7 A;  3DL1 A; 
#chains in the Genus database with same CATH homology
 1EUB A;  1KUH A;  1OS2 A;  3LUN A;  4DF9 A;  3GBO A;  1CIZ A;  2MZE A;  3MA2 A;  4XM6 A;  1O0T A;  3LMC A;  1HOV A;  3WV2 A;  1GXD A;  1GO7 P;  2W0D A;  2YIG A;  1D8F A;  1DTH A;  2OI0 A;  3O64 A;  2QPJ A;  3BA0 A;  1OMJ A;  3HY7 A;  3ZXH A;  2X3B A;  1HFC A;  3HBV P;  1I76 A;  2E2D A;  3B92 A;  2N8R A;  1Y8J A;  2MZI A;  4H76 A;  1XFU A;  1AKL A;  1B3D A;  1C7K A;  3KWV C;  1CGL A;  1D8M A;  3LK8 A;  2DDF A;  4A7B A;  1QJI A;  4AUO A;  1SLM A;  3KRY A;  5H8X A;  1CQR A;  5I2Z A;  1CXV A;  1MMP A;  2W12 A;  3AYU A;  4PKQ A;  1J7N A;  3KEK A;  3N2U A;  4DD8 A;  5B5P A;  1KBC A;  3VI1 A;  4ON1 A;  1BUV M;  4R3V A;  4FVL A;  4IN9 A;  4EFS A;  2HU6 A;  1BQQ M;  966C A;  1OM8 A;  1YQY A;  4HX3 A;  2OW0 A;  4I03 A;  4XM8 A;  1ZVX A;  2OZR A;  2WO9 A;  3LIK A;  1R1H A;  3K7L A;  2Z2D A;  3F18 A;  3AYK A;  1SU3 A;  4GWM A;  3TVC A;  2OVZ A;  1PWU A;  1JJ9 A;  2MLS A;  5BOT A;  2JT5 A;  2X3C A;  4PKW A;  2O36 A;  3E8R A;  3LUM A;  4H2E A;  4PKV A;  4GR0 A;  4L7A A;  4H30 A;  1Z3J A;  2YUF A;  3Q2H A;  1JAN A;  5BOY A;  5L7F A;  1OS9 A;  1YOU A;  3WV1 A;  3K7N A;  1PWV A;  1QIC A;  3B2Z A;  1K7I A;  2Y6C A;  1G49 A;  4ZR5 A;  1WNI A;  2E3X A;  2ERO A;  3EDG A;  3F19 A;  1QIB A;  1G05 A;  1HFS A;  4WZV A;  5B5O A;  1R54 A;  1K7G A;  2K2G A;  1I1I P;  4XBH A;  4L63 A;  2L0R A;  3F15 A;  3LKA A;  4PKT A;  4H1Q A;  3Q2G A;  5LAB A;  1JAQ A;  2XS4 A;  1K7Q A;  1SRP A;  1HTD A;  3KHI A;  3LIR A;  3LQB A;  2Y6D A;  2CLT A;  4GUY A;  3TSK A;  3DNG A;  2ERQ A;  3USN A;  1A85 A;  1BQO A;  1IAE A;  1Y0V A;  3DWB A;  3OHO A;  1D5J A;  2POJ A;  4AXQ A;  3G42 A;  4J4M A;  1XUC A;  3LGP A;  3RTS A;  2RJP A;  1IAG A;  2OY4 A;  3V96 B;  1ZXC A;  1SLN A;  3EHY A;  1ND1 A;  1G12 A;  4WKE A;  1AYK A;  1BKC I;  1XFV A;  1CGE A;  4FXY P;  456C A;  5I0L A;  1DMT A;  1IAB A;  1O0Q A;  3HBU P;  3DPF A;  2W14 A;  4JP4 A;  1R1I A;  5D1T A;  4DV8 A;  3I7I A;  1KAP P;  1GE5 A;  1UTT A;  3HDA P;  4G9L A;  1QJJ A;  1MMR A;  4XCT A;  3OHL A;  3L0V A;  1G9K A;  1JK3 A;  3B8Z A;  3F16 A;  4GF1 A;  2J0T A;  1CAQ A;  4WKI A;  3I7G A;  3O2X A;  1ZP5 A;  1MMB A;  2O3E A;  3LE9 A;  1FBL A;  2D1O A;  3EWJ A;  3G5C A;  1KUF A;  3KEC A;  1OO9 A;  2DW1 A;  3TS4 A;  3EDI A;  3EHX A;  4JPA A;  1B8Y A;  4JIJ A;  1HV5 A;  1GKD A;  2DW0 A;  3KMC A;  3P24 A;  4CTH A;  4GR8 A;  1JAP A;  4FU4 A;  1GO8 P;  1D7X A;  3ZVS A;  5I43 A;  1KUI A;  2OY2 A;  1XUR A;  2W13 A;  1FM1 A;  1XUD A;  3DTE A;  4I35 A;  1PWW A;  2OW2 A;  2MLR A;  1PWP A;  3LJT A;  4PKU A;  2OXU A;  1UEA A;  1JAO A;  1OM6 A;  5I3M A;  4FXQ A;  2AYK A;  1CK7 A;  1OM7 A;  2OXZ A;  1GKC A;  5I4O A;  4AIG A;  1RM8 A;  1RMZ A;  1UMS A;  1BKC E;  4GQL A;  1IAD A;  2D1N A;  5D7W A;  3P1V A;  1AST A;  1JIZ A;  2JNP A;  2SRT A;  2OXW A;  4HMA A;  1BZS A;  1ROS A;  2DW2 A;  4H49 A;  3AIG A;  1PWQ A;  2MZH A;  5L79 A;  3N2V A;  2JIH A;  3HYG A;  3WV3 A;  4PKR A;  1KUK A;  5D3C A;  2JSD A;  3LJG A;  4AYK A;  1GE6 A;  3DTI A;  2A8H A;  2X3A A;  2WOA A;  3VTG A;  3KEJ A;  5CXA A;  1H71 P;  2ERP A;  830C A;  5D2B A;  4H3X A;  3ELM A;  2K9C A;  4H84 A;  4XM7 A;  3LEA A;  4Q1L A;  1XFX A;  1EAK A;  1I73 A;  1SMP A;  2KRJ A;  1S4B P;  3TT4 A;  3LJZ A;  4A3W A;  1EB6 A;  1XFY A;  4ILW D;  1G4K A;  3HB2 P;  4GR3 A;  2X7M A;  4WK7 A;  1HY7 A;  3U1R A;  1CGF A;  4WF6 A;  1C3I A;  1QUA A;  4PKS A;  2W15 A;  3KME A;  2XS3 A;  2JT6 A;  5CUH A;  2FV9 A;  3RTT A;  1Y93 A;  1IAC A;  4GWN A;  1ZTQ A;  2V4B A;  3F17 A;  3NX7 A;  4IUW A;  1USN A;  2J83 A;  1C8T A;  5I12 A;  5JMY A;  5CZM A;  4G0D A;  3EDZ A;  1ATL A;  3HY9 A;  2I47 A;  3SHI A;  1AF0 A;  3CKI A;  3HDB A;  1A86 A;  4IJO A;  1YCM A;  2CKI A;  1QIA A;  2DDY A;  2OW1 A;  1YP1 A;  3DPE A;  1BKC A;  4QKZ A;  4H82 A;  1SAT A;  1ZXV A;  1BM6 A;  5D1S A;  3LIL A;  3DSL A;  3ZUK A;  2AIG P;  3L0T A;  4JA1 A;  2USN A;  1XFW A;  1JH1 A;  3EDH A;  3LQ0 A;  5D1U A;  2YB9 A;  2FV5 A;  1R55 A;  1XFZ A;  1MNC A;  1ZS0 A;  1FLS A;  3DTK A;  4L6T A;  1Q3A A;  2OW9 A;  3F1A A;  2RJQ A;  4DPE A;  2TCL A;  5BPA A;  1JIW P;  1MMQ A;  1JKY A;  3UVC A;  1L6J A;  2OVX A;  4JQG A;  1BSW A;  4L19 A;  1BUD A;  1R1J A;  1UTZ A;  2PJT A;  1IAA A;  2WO8 A;  1BIW A;  1UMT A;  1KUG A;  1GE7 A;  3DL1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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