4WKEA

Crystal structure of human adamts-4 in complex with inhibitor 5-chloro-n-{[(4r)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
214
Chain Sequence
LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 71
structure length 214
sequence length 220
ec nomenclature ec 3.4.24.82: ADAMTS-4 endopeptidase.
pdb deposition date 2014-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4wkeA00
2TCLA 2DDFA 1BM6A 4R3VA 1IAEA 4WK7A 2D1NA 5I3MA 2OW1A 1BSWA 456CA 4ILWD 1FLSA 4PKRA 3GBOA 2MZEA 2X3AA 1GKCA 1XFVA 5L7FA 1Y93A 1HV5A 1S4BP 3KRYA 4ON1A 2OXWA 4DF9A 3RTSA 1Q3AA 1MMQA 1YP1A 4H76A 1KBCA 1QJIA 1IAAA 3LUNA 5LABA 3F18A 1QIAA 1RMZA 1DMTA 1HTDA 3OHLA 1G05A 3LKAA 3LEAA 2FV5A 3HY9A 5BOYA 1CAQA 4DPEA 3MA2A 2X7MA 1K7QA 3F17A 3Q2HA 1BZSA 4XCTA 1G49A 1GE7A 1CQRA 4WKEA 3LILA 1CK7A 2W15A 5I0LA 2OXZA 3LJGA 1GKDA 2X3BA 1RM8A 1YCMA 1IAGA 1YQYA 2AYKA 2MLSA 5I2ZA 2OW2A 4JPAA 4G0DA 1KAPP 1O0TA 3LQ0A 4PKVA 2A8HA 1QIBA 4FVLA 2AIGP 5JMYA 2MLRA 1FBLA 2ERPA 3LE9A 1A85A 3DPFA 2ERQA 1D8MA 1JH1A 2OZRA 1JAQA 4L63A 3B2ZA 2OY4A 4JIJA 2K9CA 1EUBA 2FV9A 3AYKA 2JNPA 5I43A 2WO9A 1FM1A 4PKWA 3KMEA 1G4KA 3EDZA 3K7NA 3LK8A 3HY7A 3LGPA 4Q1LA 1JK3A 4PKQA 2RJQA 5I12A 1OO9A 1AYKA 3N2UA 2MZIA 4JP4A 2MZHA 2W0DA 1R54A 830CA 2CLTA 2OVZA 2OW0A 1G12A 1R1JA 3HB2P 2XS4A 1AF0A 5D3CA 1SATA 3KMCA 3DSLA 2PJTA 1SU3A 1H71P 2JT5A 3ZXHA 1HY7A 1QICA 3AYUA 3P1VA 1GXDA 1SLMA 2Z2DA 4WF6A 1GE5A 1XUDA 5BPAA 1JANA 4HMAA 3E8RA 2JIHA 1ZVXA 1C3IA 1HFSA 2W13A 1JIZA 1ASTA 5B5PA 4GR0A 2KRJA 4I35A 2E2DA 4J4MA 1ZS0A 2J0TA 3F1AA 1Z3JA 2DW0A 3EDHA 1XUCA 5D1UA 1MMRA 1KUGA 2DW2A 4GUYA 3DPEA 1KUHA 1PWUA 3ZVSA 1ZXVA 1BUVM 1XFUA 4IN9A 1B3DA 1KUKA 2I47A 2JSDA 1PWWA 2CKIA 2Y6DA 2E3XA 1IADA 2W12A 3SHIA 1ROSA 4XM7A 3HBVP 3CKIA 3UVCA 2OW9A 1R1HA 4H82A 4L6TA 2XS3A 3LMCA 4XBHA 2N8RA 3LJTA 2DDYA 3L0TA 3F15A 4FXQA 1C8TA 3N2VA 2JT6A 4JQGA 1UTZA 3O64A 1K7GA 2OXUA 3HYGA 2OY2A 1OS9A 2OVXA 4QKZA 4H49A 3DL1A 3NX7A 1PWPA 1O0QA 4GR8A 4EFSA 4H30A 1BQOA 3TVCA 3AIGA 3F16A 3LJZA 2D1OA 3HBUP 1AKLA 3LUMA 3KEKA 1EB6A 4PKSA 3TS4A 2J83A 4XM8A 4GQLA 1D7XA 2SRTA 4GR3A 2RJPA 1I1IP 3EHXA 2Y6CA 3KECA 1BUDA 1L6JA 4L19A 1JAPA 1QJJA 1I76A 1I73A 1J7NA 1MMPA 3HDAP 3WV3A 4A7BA 3O2XA 1SLNA 3USNA 5D1SA 1Y8JA 4AYKA 2DW1A 1OS2A 1K7IA 5BOTA 2V4BA 1MNCA 2POJA 1OM7A 4AXQA 3KEJA 1PWQA 4H3XA 1UEAA 3BA0A 3U1RA 3L0VA 4A3WA 1XFYA 3P24A 1MMBA 4H1QA 5CXAA 1R1IA 3KWVC 1XFZA 5CZMA 1A86A 3RTTA 1ND1A 1CGEA 4FXYP 1XFWA 4PKTA 1JJ9A 1SMPA 5D2BA 1CGFA 5CUHA 3TSKA 3VTGA 1BIWA 1BQQM 1DTHA 1UTTA 3WV2A 2WOAA 3LIKA 3TT4A 1ATLA 4XM6A 3HDBA 1OMJA 1QUAA 3LQBA 4ZR5A 5I4OA 3EHYA 4JA1A 5D7WA 4I03A 2OI0A 3LIRA 1BKCE 4AUOA 5B5OA 1IACA 2YB9A 4H2EA 1JIWP 3WV1A 3KHIA 4WZVA 3K7LA 1JAOA 1PWVA 5L79A 1JKYA 4IJOA 1SRPA 2O3EA 4AIGA 1D8FA 2L0RA 2USNA 3B8ZA 1UMTA 2WO8A 1OM8A 4FU4A 4PKUA 4DD8A 1KUFA 966CA 2X3CA 4DV8A 3ZUKA 4GF1A 2W14A 4CTHA 3F19A 3OHOA 3EDIA 2YIGA 1Y0VA 1CGLA 1HOVA 3DWBA 3ELMA 4GWMA 1IABA 4H84A 1BKCA 1UMSA 3DNGA 1GO8P 4HX3A 1GE6A 1XURA 1B8YA 3I7IA 1CXVA 3I7GA 3EWJA 1C7KA 1HFCA 3Q2GA 4G9LA 3EDGA 1R55A 3VI1A 1KUIA 2K2GA 3B92A 1CIZA 3G5CA 2EROA 1D5JA 3V96B 1GO7P 3G42A 5D1TA 1WNIA 1YOUA 1ZXCA 2O36A 1G9KA 1ZP5A 1OM6A 1XFXA 1ZTQA 2HU6A 4WKIA 1BKCI 1EAKA 4GWNA 1USNA 4IUWA 5H8XA 2QPJA
chains in the Genus database with same CATH superfamily
2TCLA 2DDFA 1BM6A 4R3VA 1IAEA 4WK7A 2D1NA 5I3MA 1OZ9A 2OW1A 1BSWA 456CA 4ILWD 1FLSA 4PKRA 3GBOA 2MZEA 2X3AA 1GKCA 1XFVA 5L7FA 1Y93A 1HV5A 1S4BP 3KRYA 4ON1A 2OXWA 4DF9A 3RTSA 1Q3AA 1MMQA 1YP1A 4H76A 1KBCA 1QJIA 1IAAA 3LUNA 5LABA 3F18A 1QIAA 1RMZA 1DMTA 1HTDA 3OHLA 1G05A 3LKAA 3LEAA 2FV5A 3HY9A 5BOYA 1CAQA 4DPEA 3MA2A 2X7MA 1XAXA 1K7QA 3F17A 3Q2HA 1BZSA 4XCTA 1G49A 1GE7A 1CQRA 4WKEA 3LILA 1CK7A 2W15A 5I0LA 2OXZA 3LJGA 1GKDA 2X3BA 1RM8A 1YCMA 1IAGA 1YQYA 2AYKA 2MLSA 5I2ZA 2OW2A 4JPAA 3DTKA 4G0DA 1KAPP 1O0TA 3LQ0A 4PKVA 2A8HA 1QIBA 4FVLA 2AIGP 5JMYA 2MLRA 1FBLA 2ERPA 3LE9A 1A85A 3DPFA 2ERQA 1D8MA 1JH1A 2OZRA 1JAQA 4L63A 3B2ZA 2OY4A 4JIJA 2K9CA 1EUBA 2FV9A 3AYKA 2JNPA 5I43A 2WO9A 1FM1A 4PKWA 3KMEA 1G4KA 3EDZA 3K7NA 3LK8A 3HY7A 3LGPA 4Q1LA 1JK3A 4PKQA 2RJQA 4L7AA 5I12A 1OO9A 1AYKA 3N2UA 2MZIA 4JP4A 2MZHA 2W0DA 1R54A 830CA 2CLTA 2OVZA 2OW0A 1G12A 1R1JA 3HB2P 2XS4A 1AF0A 5D3CA 1SATA 3KMCA 3DSLA 2PJTA 3DTIA 1SU3A 1H71P 2JT5A 3ZXHA 1HY7A 1QICA 3AYUA 3P1VA 1GXDA 1SLMA 2Z2DA 4WF6A 1GE5A 1XUDA 5BPAA 1JANA 4HMAA 3E8RA 2JIHA 1ZVXA 1C3IA 1HFSA 2W13A 1JIZA 1ASTA 5B5PA 4GR0A 2KRJA 4I35A 2E2DA 4J4MA 1ZS0A 2J0TA 3F1AA 1Z3JA 2DW0A 2YUFA 3EDHA 1XUCA 5D1UA 1MMRA 1KUGA 2DW2A 4GUYA 3DPEA 3DTEA 1KUHA 1PWUA 3ZVSA 1ZXVA 1BUVM 1XFUA 4IN9A 1B3DA 1KUKA 2I47A 2JSDA 1PWWA 2CKIA 2Y6DA 2E3XA 1IADA 2W12A 3SHIA 1ROSA 4XM7A 3HBVP 3CKIA 3UVCA 2OW9A 1R1HA 4H82A 4L6TA 2XS3A 3LMCA 4XBHA 2N8RA 3LJTA 2DDYA 3L0TA 3F15A 4FXQA 1C8TA 3N2VA 2JT6A 4JQGA 1UTZA 3O64A 1K7GA 2OXUA 3HYGA 2OY2A 1OS9A 2OVXA 4QKZA 4H49A 3DL1A 3NX7A 1PWPA 1O0QA 4GR8A 4EFSA 4H30A 1BQOA 3TVCA 3AIGA 3F16A 3LJZA 2D1OA 3HBUP 1AKLA 3LUMA 3KEKA 1EB6A 4PKSA 3TS4A 2J83A 4XM8A 4GQLA 1D7XA 2SRTA 4GR3A 2RJPA 1I1IP 3EHXA 2Y6CA 3KECA 1BUDA 1L6JA 4L19A 1JAPA 1QJJA 1I76A 1I73A 1J7NA 1MMPA 3HDAP 3WV3A 4A7BA 3O2XA 1SLNA 3USNA 5D1SA 1Y8JA 4AYKA 2DW1A 1OS2A 1K7IA 5BOTA 2V4BA 1MNCA 2POJA 1OM7A 4AXQA 1TVIA 3KEJA 1PWQA 4H3XA 1UEAA 3BA0A 3U1RA 3L0VA 4A3WA 1XFYA 3P24A 1MMBA 4H1QA 5CXAA 1R1IA 3KWVC 1XFZA 5CZMA 1A86A 3RTTA 1ND1A 1CGEA 4FXYP 1XFWA 4PKTA 1JJ9A 1SMPA 5D2BA 1CGFA 5CUHA 3TSKA 3VTGA 1BIWA 1BQQM 1DTHA 1UTTA 3WV2A 2WOAA 3LIKA 3TT4A 1ATLA 4XM6A 3HDBA 1OMJA 1QUAA 3LQBA 4ZR5A 5I4OA 3EHYA 4JA1A 5D7WA 4I03A 2OI0A 3LIRA 1BKCE 4AUOA 5B5OA 1IACA 2YB9A 4H2EA 1JIWP 3WV1A 1XM5A 3KHIA 3K7LA 4WZVA 1JAOA 1PWVA 5L79A 1JKYA 4IJOA 1SRPA 2O3EA 4AIGA 1D8FA 2L0RA 2USNA 3B8ZA 1UMTA 2WO8A 1OM8A 4FU4A 4PKUA 4DD8A 1KUFA 966CA 2X3CA 4DV8A 3ZUKA 4GF1A 2W14A 4CTHA 3F19A 3OHOA 3EDIA 2YIGA 1Y0VA 1CGLA 1HOVA 3DWBA 3ELMA 4GWMA 1IABA 4H84A 1BKCA 1UMSA 3DNGA 1GO8P 4HX3A 1GE6A 1XURA 1B8YA 3I7IA 1CXVA 3I7GA 3EWJA 1C7KA 1HFCA 3Q2GA 4G9LA 3EDGA 1R55A 3VI1A 1KUIA 2K2GA 3B92A 1CIZA 3G5CA 2EROA 1D5JA 3V96B 1GO7P 3G42A 5D1TA 1WNIA 1YOUA 1ZXCA 2O36A 1G9KA 1ZP5A 1OM6A 1XFXA 1ZTQA 2HU6A 4WKIA 1BKCI 1EAKA 4GWNA 1USNA 4IUWA 5H8XA 2QPJA
chains in the Genus database with same CATH topology
2TCLA 2DDFA 1BM6A 4R3VA 1IAEA 4WK7A 2D1NA 5I3MA 2OW1A 1BSWA 456CA 4ILWD 1FLSA 4PKRA 3GBOA 2MZEA 2X3AA 1GKCA 1XFVA 5L7FA 1Y93A 1HV5A 1S4BP 3KRYA 4ON1A 2OXWA 4DF9A 3RTSA 1Q3AA 1MMQA 1YP1A 4H76A 1KBCA 1QJIA 1IAAA 3LUNA 5LABA 3F18A 1QIAA 1RMZA 1DMTA 1HTDA 3OHLA 1G05A 3LKAA 3LEAA 2FV5A 3HY9A 5BOYA 1CAQA 4DPEA 3MA2A 2X7MA 1K7QA 3F17A 3Q2HA 1BZSA 4XCTA 1G49A 1GE7A 1CQRA 4WKEA 3LILA 1CK7A 2W15A 5I0LA 2OXZA 3LJGA 1GKDA 2X3BA 1RM8A 1YCMA 1IAGA 1YQYA 2AYKA 2MLSA 5I2ZA 2OW2A 4JPAA 3DTKA 4G0DA 1KAPP 1O0TA 3LQ0A 4PKVA 2A8HA 1QIBA 4FVLA 2AIGP 5JMYA 2MLRA 1FBLA 2ERPA 3LE9A 1A85A 3DPFA 2ERQA 1D8MA 1JH1A 2OZRA 1JAQA 4L63A 3B2ZA 2OY4A 4JIJA 2K9CA 1EUBA 2FV9A 3AYKA 2JNPA 5I43A 2WO9A 1FM1A 4PKWA 3KMEA 1G4KA 3EDZA 3K7NA 3LK8A 3HY7A 3LGPA 4Q1LA 1JK3A 4PKQA 2RJQA 4L7AA 5I12A 1OO9A 1AYKA 3N2UA 2MZIA 4JP4A 2MZHA 2W0DA 1R54A 830CA 2CLTA 2OVZA 2OW0A 1G12A 1R1JA 3HB2P 2XS4A 1AF0A 5D3CA 1SATA 3KMCA 3DSLA 2PJTA 3DTIA 1SU3A 1H71P 2JT5A 3ZXHA 1HY7A 1QICA 3AYUA 3P1VA 1GXDA 1SLMA 2Z2DA 4WF6A 1GE5A 1XUDA 5BPAA 1JANA 4HMAA 3E8RA 2JIHA 1ZVXA 1C3IA 1HFSA 2W13A 1JIZA 1ASTA 5B5PA 4GR0A 2KRJA 4I35A 2E2DA 4J4MA 1ZS0A 2J0TA 3F1AA 1Z3JA 2DW0A 2YUFA 3EDHA 1XUCA 5D1UA 1MMRA 1KUGA 2DW2A 4GUYA 3DPEA 3DTEA 1KUHA 1PWUA 3ZVSA 1ZXVA 1BUVM 1XFUA 4IN9A 1B3DA 1KUKA 2I47A 2JSDA 1PWWA 2CKIA 2Y6DA 2E3XA 1IADA 2W12A 3SHIA 1ROSA 4XM7A 3HBVP 3CKIA 3UVCA 2OW9A 1R1HA 4H82A 4L6TA 2XS3A 3LMCA 4XBHA 2N8RA 3LJTA 2DDYA 3L0TA 3F15A 4FXQA 1C8TA 3N2VA 2JT6A 4JQGA 1UTZA 3O64A 1K7GA 2OXUA 3HYGA 2OY2A 1OS9A 2OVXA 4QKZA 4H49A 3DL1A 3NX7A 1PWPA 1O0QA 4GR8A 4EFSA 4H30A 1BQOA 3TVCA 3AIGA 3F16A 3LJZA 2D1OA 3HBUP 1AKLA 3LUMA 3KEKA 1EB6A 4PKSA 3TS4A 2J83A 4XM8A 4GQLA 1D7XA 2SRTA 4GR3A 2RJPA 1I1IP 3EHXA 2Y6CA 3KECA 1BUDA 1L6JA 4L19A 1JAPA 1QJJA 1I76A 1I73A 1J7NA 1MMPA 3HDAP 3WV3A 4A7BA 3O2XA 1SLNA 3USNA 5D1SA 1Y8JA 4AYKA 2DW1A 1OS2A 1K7IA 5BOTA 2V4BA 1MNCA 2POJA 1OM7A 4AXQA 3KEJA 1PWQA 4H3XA 1UEAA 3BA0A 3U1RA 3L0VA 4A3WA 1XFYA 3P24A 1MMBA 4H1QA 5CXAA 1R1IA 3KWVC 1XFZA 5CZMA 1A86A 3RTTA 1ND1A 1CGEA 4FXYP 1XFWA 4PKTA 1JJ9A 1SMPA 5D2BA 1CGFA 5CUHA 3TSKA 3VTGA 1BIWA 1BQQM 1DTHA 1UTTA 3WV2A 2WOAA 3LIKA 3TT4A 1ATLA 4XM6A 3HDBA 1OMJA 1QUAA 3LQBA 4ZR5A 5I4OA 3EHYA 4JA1A 5D7WA 4I03A 2OI0A 3LIRA 1BKCE 4AUOA 5B5OA 1IACA 2YB9A 4H2EA 1JIWP 3WV1A 3KHIA 4WZVA 3K7LA 1JAOA 1PWVA 5L79A 1JKYA 4IJOA 1SRPA 2O3EA 4AIGA 1D8FA 2L0RA 2USNA 3B8ZA 1UMTA 2WO8A 1OM8A 4FU4A 4PKUA 4DD8A 1KUFA 966CA 2X3CA 4DV8A 3ZUKA 4GF1A 2W14A 4CTHA 3F19A 3OHOA 3EDIA 2YIGA 1Y0VA 1CGLA 1HOVA 3DWBA 3ELMA 4GWMA 1IABA 4H84A 1BKCA 1UMSA 3DNGA 1GO8P 4HX3A 1GE6A 1XURA 1B8YA 3I7IA 1CXVA 3I7GA 3EWJA 1C7KA 1HFCA 3Q2GA 4G9LA 3EDGA 1R55A 3VI1A 1KUIA 2K2GA 3B92A 1CIZA 3G5CA 2EROA 1D5JA 3V96B 1GO7P 3G42A 5D1TA 1WNIA 1YOUA 1ZXCA 2O36A 1G9KA 1ZP5A 1OM6A 1XFXA 1ZTQA 2HU6A 4WKIA 1BKCI 1EAKA 4GWNA 1USNA 4IUWA 5H8XA 2QPJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2TCL A;  2DDF A;  1BM6 A;  4R3V A;  1IAE A;  4WK7 A;  2D1N A;  5I3M A;  2OW1 A;  1BSW A;  456C A;  4ILW D;  1FLS A;  4PKR A;  3GBO A;  2MZE A;  2X3A A;  1GKC A;  1XFV A;  5L7F A;  1Y93 A;  1HV5 A;  1S4B P;  3KRY A;  4ON1 A;  2OXW A;  4DF9 A;  3RTS A;  1Q3A A;  1MMQ A;  1YP1 A;  4H76 A;  1KBC A;  1QJI A;  1IAA A;  3LUN A;  5LAB A;  3F18 A;  1QIA A;  1RMZ A;  1DMT A;  1HTD A;  3OHL A;  1G05 A;  3LKA A;  3LEA A;  2FV5 A;  3HY9 A;  5BOY A;  1CAQ A;  4DPE A;  3MA2 A;  2X7M A;  1K7Q A;  3F17 A;  3Q2H A;  1BZS A;  4XCT A;  1G49 A;  1GE7 A;  1CQR A;  4WKE A;  3LIL A;  1CK7 A;  2W15 A;  5I0L A;  2OXZ A;  3LJG A;  1GKD A;  2X3B A;  1RM8 A;  1YCM A;  1IAG A;  1YQY A;  2AYK A;  2MLS A;  5I2Z A;  2OW2 A;  4JPA A;  4G0D A;  1KAP P;  1O0T A;  3LQ0 A;  4PKV A;  2A8H A;  1QIB A;  4FVL A;  2AIG P;  5JMY A;  2MLR A;  1FBL A;  2ERP A;  3LE9 A;  1A85 A;  3DPF A;  2ERQ A;  1D8M A;  1JH1 A;  2OZR A;  1JAQ A;  4L63 A;  3B2Z A;  2OY4 A;  4JIJ A;  2K9C A;  1EUB A;  2FV9 A;  3AYK A;  2JNP A;  5I43 A;  2WO9 A;  1FM1 A;  4PKW A;  3KME A;  1G4K A;  3EDZ A;  3K7N A;  3LK8 A;  3HY7 A;  3LGP A;  4Q1L A;  1JK3 A;  4PKQ A;  2RJQ A;  5I12 A;  1OO9 A;  1AYK A;  3N2U A;  2MZI A;  4JP4 A;  2MZH A;  2W0D A;  1R54 A;  830C A;  2CLT A;  2OVZ A;  2OW0 A;  1G12 A;  1R1J A;  3HB2 P;  2XS4 A;  1AF0 A;  5D3C A;  1SAT A;  3KMC A;  3DSL A;  2PJT A;  1SU3 A;  1H71 P;  2JT5 A;  3ZXH A;  1HY7 A;  1QIC A;  3AYU A;  3P1V A;  1GXD A;  1SLM A;  2Z2D A;  4WF6 A;  1GE5 A;  1XUD A;  5BPA A;  1JAN A;  4HMA A;  3E8R A;  2JIH A;  1ZVX A;  1C3I A;  1HFS A;  2W13 A;  1JIZ A;  1AST A;  5B5P A;  4GR0 A;  2KRJ A;  4I35 A;  2E2D A;  4J4M A;  1ZS0 A;  2J0T A;  3F1A A;  1Z3J A;  2DW0 A;  3EDH A;  1XUC A;  5D1U A;  1MMR A;  1KUG A;  2DW2 A;  4GUY A;  3DPE A;  1KUH A;  1PWU A;  3ZVS A;  1ZXV A;  1BUV M;  1XFU A;  4IN9 A;  1B3D A;  1KUK A;  2I47 A;  2JSD A;  1PWW A;  2CKI A;  2Y6D A;  2E3X A;  1IAD A;  2W12 A;  3SHI A;  1ROS A;  4XM7 A;  3HBV P;  3CKI A;  3UVC A;  2OW9 A;  1R1H A;  4H82 A;  4L6T A;  2XS3 A;  3LMC A;  4XBH A;  2N8R A;  3LJT A;  2DDY A;  3L0T A;  3F15 A;  4FXQ A;  1C8T A;  3N2V A;  2JT6 A;  4JQG A;  1UTZ A;  3O64 A;  1K7G A;  2OXU A;  3HYG A;  2OY2 A;  1OS9 A;  2OVX A;  4QKZ A;  4H49 A;  3DL1 A;  3NX7 A;  1PWP A;  1O0Q A;  4GR8 A;  4EFS A;  4H30 A;  1BQO A;  3TVC A;  3AIG A;  3F16 A;  3LJZ A;  2D1O A;  3HBU P;  1AKL A;  3LUM A;  3KEK A;  1EB6 A;  4PKS A;  3TS4 A;  2J83 A;  4XM8 A;  4GQL A;  1D7X A;  2SRT A;  4GR3 A;  2RJP A;  1I1I P;  3EHX A;  2Y6C A;  3KEC A;  1BUD A;  1L6J A;  4L19 A;  1JAP A;  1QJJ A;  1I76 A;  1I73 A;  1J7N A;  1MMP A;  3HDA P;  3WV3 A;  4A7B A;  3O2X A;  1SLN A;  3USN A;  5D1S A;  1Y8J A;  4AYK A;  2DW1 A;  1OS2 A;  1K7I A;  5BOT A;  2V4B A;  1MNC A;  2POJ A;  1OM7 A;  4AXQ A;  3KEJ A;  1PWQ A;  4H3X A;  1UEA A;  3BA0 A;  3U1R A;  3L0V A;  4A3W A;  1XFY A;  3P24 A;  1MMB A;  4H1Q A;  5CXA A;  1R1I A;  3KWV C;  1XFZ A;  5CZM A;  1A86 A;  3RTT A;  1ND1 A;  1CGE A;  4FXY P;  1XFW A;  4PKT A;  1JJ9 A;  1SMP A;  5D2B A;  1CGF A;  5CUH A;  3TSK A;  3VTG A;  1BIW A;  1BQQ M;  1DTH A;  1UTT A;  3WV2 A;  2WOA A;  3LIK A;  3TT4 A;  1ATL A;  4XM6 A;  3HDB A;  1OMJ A;  1QUA A;  3LQB A;  4ZR5 A;  5I4O A;  3EHY A;  4JA1 A;  5D7W A;  4I03 A;  2OI0 A;  3LIR A;  1BKC E;  4AUO A;  5B5O A;  1IAC A;  2YB9 A;  4H2E A;  1JIW P;  3WV1 A;  3KHI A;  4WZV A;  3K7L A;  1JAO A;  1PWV A;  5L79 A;  1JKY A;  4IJO A;  1SRP A;  2O3E A;  4AIG A;  1D8F A;  2L0R A;  2USN A;  3B8Z A;  1UMT A;  2WO8 A;  1OM8 A;  4FU4 A;  4PKU A;  4DD8 A;  1KUF A;  966C A;  2X3C A;  4DV8 A;  3ZUK A;  4GF1 A;  2W14 A;  4CTH A;  3F19 A;  3OHO A;  3EDI A;  2YIG A;  1Y0V A;  1CGL A;  1HOV A;  3DWB A;  3ELM A;  4GWM A;  1IAB A;  4H84 A;  1BKC A;  1UMS A;  3DNG A;  1GO8 P;  4HX3 A;  1GE6 A;  1XUR A;  1B8Y A;  3I7I A;  1CXV A;  3I7G A;  3EWJ A;  1C7K A;  1HFC A;  3Q2G A;  4G9L A;  3EDG A;  1R55 A;  3VI1 A;  1KUI A;  2K2G A;  3B92 A;  1CIZ A;  3G5C A;  2ERO A;  1D5J A;  3V96 B;  1GO7 P;  3G42 A;  5D1T A;  1WNI A;  1YOU A;  1ZXC A;  2O36 A;  1G9K A;  1ZP5 A;  1OM6 A;  1XFX A;  1ZTQ A;  2HU6 A;  4WKI A;  1BKC I;  1EAK A;  4GWN A;  1USN A;  4IUW A;  5H8X A;  2QPJ A; 
#chains in the Genus database with same CATH topology
 2TCL A;  2DDF A;  1BM6 A;  4R3V A;  1IAE A;  4WK7 A;  2D1N A;  5I3M A;  1OZ9 A;  2OW1 A;  1BSW A;  456C A;  4ILW D;  1FLS A;  4PKR A;  3GBO A;  2MZE A;  2X3A A;  1GKC A;  1XFV A;  5L7F A;  1Y93 A;  1HV5 A;  1S4B P;  3KRY A;  4ON1 A;  2OXW A;  4DF9 A;  3RTS A;  1Q3A A;  1MMQ A;  1YP1 A;  4H76 A;  1KBC A;  1QJI A;  1IAA A;  3LUN A;  5LAB A;  3F18 A;  1QIA A;  1RMZ A;  1DMT A;  1HTD A;  3OHL A;  1G05 A;  3LKA A;  3LEA A;  2FV5 A;  3HY9 A;  5BOY A;  1CAQ A;  4DPE A;  3MA2 A;  2X7M A;  1XAX A;  1K7Q A;  3F17 A;  3Q2H A;  1BZS A;  4XCT A;  1G49 A;  1GE7 A;  1CQR A;  4WKE A;  3LIL A;  1CK7 A;  2W15 A;  5I0L A;  2OXZ A;  3LJG A;  1GKD A;  2X3B A;  1RM8 A;  1YCM A;  1IAG A;  1YQY A;  2AYK A;  2MLS A;  5I2Z A;  2OW2 A;  4JPA A;  3DTK A;  4G0D A;  1KAP P;  1O0T A;  3LQ0 A;  4PKV A;  2A8H A;  1QIB A;  4FVL A;  2AIG P;  5JMY A;  2MLR A;  1FBL A;  2ERP A;  3LE9 A;  1A85 A;  3DPF A;  2ERQ A;  1D8M A;  1JH1 A;  2OZR A;  1JAQ A;  4L63 A;  3B2Z A;  2OY4 A;  4JIJ A;  2K9C A;  1EUB A;  2FV9 A;  3AYK A;  2JNP A;  5I43 A;  2WO9 A;  1FM1 A;  4PKW A;  3KME A;  1G4K A;  3EDZ A;  3K7N A;  3LK8 A;  3HY7 A;  3LGP A;  4Q1L A;  1JK3 A;  4PKQ A;  2RJQ A;  4L7A A;  5I12 A;  1OO9 A;  1AYK A;  3N2U A;  2MZI A;  4JP4 A;  2MZH A;  2W0D A;  1R54 A;  830C A;  2CLT A;  2OVZ A;  2OW0 A;  1G12 A;  1R1J A;  3HB2 P;  2XS4 A;  1AF0 A;  5D3C A;  1SAT A;  3KMC A;  3DSL A;  2PJT A;  3DTI A;  1SU3 A;  1H71 P;  2JT5 A;  3ZXH A;  1HY7 A;  1QIC A;  3AYU A;  3P1V A;  1GXD A;  1SLM A;  2Z2D A;  4WF6 A;  1GE5 A;  1XUD A;  5BPA A;  1JAN A;  4HMA A;  3E8R A;  2JIH A;  1ZVX A;  1C3I A;  1HFS A;  2W13 A;  1JIZ A;  1AST A;  5B5P A;  4GR0 A;  2KRJ A;  4I35 A;  2E2D A;  4J4M A;  1ZS0 A;  2J0T A;  3F1A A;  1Z3J A;  2DW0 A;  2YUF A;  3EDH A;  1XUC A;  5D1U A;  1MMR A;  1KUG A;  2DW2 A;  4GUY A;  3DPE A;  3DTE A;  1KUH A;  1PWU A;  3ZVS A;  1ZXV A;  1BUV M;  1XFU A;  4IN9 A;  1B3D A;  1KUK A;  2I47 A;  2JSD A;  1PWW A;  2CKI A;  2Y6D A;  2E3X A;  1IAD A;  2W12 A;  3SHI A;  1ROS A;  4XM7 A;  3HBV P;  3CKI A;  3UVC A;  2OW9 A;  1R1H A;  4H82 A;  4L6T A;  2XS3 A;  3LMC A;  4XBH A;  2N8R A;  3LJT A;  2DDY A;  3L0T A;  3F15 A;  4FXQ A;  1C8T A;  3N2V A;  2JT6 A;  4JQG A;  1UTZ A;  3O64 A;  1K7G A;  2OXU A;  3HYG A;  2OY2 A;  1OS9 A;  2OVX A;  4QKZ A;  4H49 A;  3DL1 A;  3NX7 A;  1PWP A;  1O0Q A;  4GR8 A;  4EFS A;  4H30 A;  1BQO A;  3TVC A;  3AIG A;  3F16 A;  3LJZ A;  2D1O A;  3HBU P;  1AKL A;  3LUM A;  3KEK A;  1EB6 A;  4PKS A;  3TS4 A;  2J83 A;  4XM8 A;  4GQL A;  1D7X A;  2SRT A;  4GR3 A;  2RJP A;  1I1I P;  3EHX A;  2Y6C A;  3KEC A;  1BUD A;  1L6J A;  4L19 A;  1JAP A;  1QJJ A;  1I76 A;  1I73 A;  1J7N A;  1MMP A;  3HDA P;  3WV3 A;  4A7B A;  3O2X A;  1SLN A;  3USN A;  5D1S A;  1Y8J A;  4AYK A;  2DW1 A;  1OS2 A;  1K7I A;  5BOT A;  2V4B A;  1MNC A;  2POJ A;  1OM7 A;  4AXQ A;  1TVI A;  3KEJ A;  1PWQ A;  4H3X A;  1UEA A;  3BA0 A;  3U1R A;  3L0V A;  4A3W A;  1XFY A;  3P24 A;  1MMB A;  4H1Q A;  5CXA A;  1R1I A;  3KWV C;  1XFZ A;  5CZM A;  1A86 A;  3RTT A;  1ND1 A;  1CGE A;  4FXY P;  1XFW A;  4PKT A;  1JJ9 A;  1SMP A;  5D2B A;  1CGF A;  5CUH A;  3TSK A;  3VTG A;  1BIW A;  1BQQ M;  1DTH A;  1UTT A;  3WV2 A;  2WOA A;  3LIK A;  3TT4 A;  1ATL A;  4XM6 A;  3HDB A;  1OMJ A;  1QUA A;  3LQB A;  4ZR5 A;  5I4O A;  3EHY A;  4JA1 A;  5D7W A;  4I03 A;  2OI0 A;  3LIR A;  1BKC E;  4AUO A;  5B5O A;  1IAC A;  2YB9 A;  4H2E A;  1JIW P;  3WV1 A;  1XM5 A;  3KHI A;  3K7L A;  4WZV A;  1JAO A;  1PWV A;  5L79 A;  1JKY A;  4IJO A;  1SRP A;  2O3E A;  4AIG A;  1D8F A;  2L0R A;  2USN A;  3B8Z A;  1UMT A;  2WO8 A;  1OM8 A;  4FU4 A;  4PKU A;  4DD8 A;  1KUF A;  966C A;  2X3C A;  4DV8 A;  3ZUK A;  4GF1 A;  2W14 A;  4CTH A;  3F19 A;  3OHO A;  3EDI A;  2YIG A;  1Y0V A;  1CGL A;  1HOV A;  3DWB A;  3ELM A;  4GWM A;  1IAB A;  4H84 A;  1BKC A;  1UMS A;  3DNG A;  1GO8 P;  4HX3 A;  1GE6 A;  1XUR A;  1B8Y A;  3I7I A;  1CXV A;  3I7G A;  3EWJ A;  1C7K A;  1HFC A;  3Q2G A;  4G9L A;  3EDG A;  1R55 A;  3VI1 A;  1KUI A;  2K2G A;  3B92 A;  1CIZ A;  3G5C A;  2ERO A;  1D5J A;  3V96 B;  1GO7 P;  3G42 A;  5D1T A;  1WNI A;  1YOU A;  1ZXC A;  2O36 A;  1G9K A;  1ZP5 A;  1OM6 A;  1XFX A;  1ZTQ A;  2HU6 A;  4WKI A;  1BKC I;  1EAK A;  4GWN A;  1USN A;  4IUW A;  5H8X A;  2QPJ A; 
#chains in the Genus database with same CATH homology
 2TCL A;  2DDF A;  1BM6 A;  4R3V A;  1IAE A;  4WK7 A;  2D1N A;  5I3M A;  2OW1 A;  1BSW A;  456C A;  4ILW D;  1FLS A;  4PKR A;  3GBO A;  2MZE A;  2X3A A;  1GKC A;  1XFV A;  5L7F A;  1Y93 A;  1HV5 A;  1S4B P;  3KRY A;  4ON1 A;  2OXW A;  4DF9 A;  3RTS A;  1Q3A A;  1MMQ A;  1YP1 A;  4H76 A;  1KBC A;  1QJI A;  1IAA A;  3LUN A;  5LAB A;  3F18 A;  1QIA A;  1RMZ A;  1DMT A;  1HTD A;  3OHL A;  1G05 A;  3LKA A;  3LEA A;  2FV5 A;  3HY9 A;  5BOY A;  1CAQ A;  4DPE A;  3MA2 A;  2X7M A;  1K7Q A;  3F17 A;  3Q2H A;  1BZS A;  4XCT A;  1G49 A;  1GE7 A;  1CQR A;  4WKE A;  3LIL A;  1CK7 A;  2W15 A;  5I0L A;  2OXZ A;  3LJG A;  1GKD A;  2X3B A;  1RM8 A;  1YCM A;  1IAG A;  1YQY A;  2AYK A;  2MLS A;  5I2Z A;  2OW2 A;  4JPA A;  3DTK A;  4G0D A;  1KAP P;  1O0T A;  3LQ0 A;  4PKV A;  2A8H A;  1QIB A;  4FVL A;  2AIG P;  5JMY A;  2MLR A;  1FBL A;  2ERP A;  3LE9 A;  1A85 A;  3DPF A;  2ERQ A;  1D8M A;  1JH1 A;  2OZR A;  1JAQ A;  4L63 A;  3B2Z A;  2OY4 A;  4JIJ A;  2K9C A;  1EUB A;  2FV9 A;  3AYK A;  2JNP A;  5I43 A;  2WO9 A;  1FM1 A;  4PKW A;  3KME A;  1G4K A;  3EDZ A;  3K7N A;  3LK8 A;  3HY7 A;  3LGP A;  4Q1L A;  1JK3 A;  4PKQ A;  2RJQ A;  4L7A A;  5I12 A;  1OO9 A;  1AYK A;  3N2U A;  2MZI A;  4JP4 A;  2MZH A;  2W0D A;  1R54 A;  830C A;  2CLT A;  2OVZ A;  2OW0 A;  1G12 A;  1R1J A;  3HB2 P;  2XS4 A;  1AF0 A;  5D3C A;  1SAT A;  3KMC A;  3DSL A;  2PJT A;  3DTI A;  1SU3 A;  1H71 P;  2JT5 A;  3ZXH A;  1HY7 A;  1QIC A;  3AYU A;  3P1V A;  1GXD A;  1SLM A;  2Z2D A;  4WF6 A;  1GE5 A;  1XUD A;  5BPA A;  1JAN A;  4HMA A;  3E8R A;  2JIH A;  1ZVX A;  1C3I A;  1HFS A;  2W13 A;  1JIZ A;  1AST A;  5B5P A;  4GR0 A;  2KRJ A;  4I35 A;  2E2D A;  4J4M A;  1ZS0 A;  2J0T A;  3F1A A;  1Z3J A;  2DW0 A;  2YUF A;  3EDH A;  1XUC A;  5D1U A;  1MMR A;  1KUG A;  2DW2 A;  4GUY A;  3DPE A;  3DTE A;  1KUH A;  1PWU A;  3ZVS A;  1ZXV A;  1BUV M;  1XFU A;  4IN9 A;  1B3D A;  1KUK A;  2I47 A;  2JSD A;  1PWW A;  2CKI A;  2Y6D A;  2E3X A;  1IAD A;  2W12 A;  3SHI A;  1ROS A;  4XM7 A;  3HBV P;  3CKI A;  3UVC A;  2OW9 A;  1R1H A;  4H82 A;  4L6T A;  2XS3 A;  3LMC A;  4XBH A;  2N8R A;  3LJT A;  2DDY A;  3L0T A;  3F15 A;  4FXQ A;  1C8T A;  3N2V A;  2JT6 A;  4JQG A;  1UTZ A;  3O64 A;  1K7G A;  2OXU A;  3HYG A;  2OY2 A;  1OS9 A;  2OVX A;  4QKZ A;  4H49 A;  3DL1 A;  3NX7 A;  1PWP A;  1O0Q A;  4GR8 A;  4EFS A;  4H30 A;  1BQO A;  3TVC A;  3AIG A;  3F16 A;  3LJZ A;  2D1O A;  3HBU P;  1AKL A;  3LUM A;  3KEK A;  1EB6 A;  4PKS A;  3TS4 A;  2J83 A;  4XM8 A;  4GQL A;  1D7X A;  2SRT A;  4GR3 A;  2RJP A;  1I1I P;  3EHX A;  2Y6C A;  3KEC A;  1BUD A;  1L6J A;  4L19 A;  1JAP A;  1QJJ A;  1I76 A;  1I73 A;  1J7N A;  1MMP A;  3HDA P;  3WV3 A;  4A7B A;  3O2X A;  1SLN A;  3USN A;  5D1S A;  1Y8J A;  4AYK A;  2DW1 A;  1OS2 A;  1K7I A;  5BOT A;  2V4B A;  1MNC A;  2POJ A;  1OM7 A;  4AXQ A;  3KEJ A;  1PWQ A;  4H3X A;  1UEA A;  3BA0 A;  3U1R A;  3L0V A;  4A3W A;  1XFY A;  3P24 A;  1MMB A;  4H1Q A;  5CXA A;  1R1I A;  3KWV C;  1XFZ A;  5CZM A;  1A86 A;  3RTT A;  1ND1 A;  1CGE A;  4FXY P;  1XFW A;  4PKT A;  1JJ9 A;  1SMP A;  5D2B A;  1CGF A;  5CUH A;  3TSK A;  3VTG A;  1BIW A;  1BQQ M;  1DTH A;  1UTT A;  3WV2 A;  2WOA A;  3LIK A;  3TT4 A;  1ATL A;  4XM6 A;  3HDB A;  1OMJ A;  1QUA A;  3LQB A;  4ZR5 A;  5I4O A;  3EHY A;  4JA1 A;  5D7W A;  4I03 A;  2OI0 A;  3LIR A;  1BKC E;  4AUO A;  5B5O A;  1IAC A;  2YB9 A;  4H2E A;  1JIW P;  3WV1 A;  3KHI A;  4WZV A;  3K7L A;  1JAO A;  1PWV A;  5L79 A;  1JKY A;  4IJO A;  1SRP A;  2O3E A;  4AIG A;  1D8F A;  2L0R A;  2USN A;  3B8Z A;  1UMT A;  2WO8 A;  1OM8 A;  4FU4 A;  4PKU A;  4DD8 A;  1KUF A;  966C A;  2X3C A;  4DV8 A;  3ZUK A;  4GF1 A;  2W14 A;  4CTH A;  3F19 A;  3OHO A;  3EDI A;  2YIG A;  1Y0V A;  1CGL A;  1HOV A;  3DWB A;  3ELM A;  4GWM A;  1IAB A;  4H84 A;  1BKC A;  1UMS A;  3DNG A;  1GO8 P;  4HX3 A;  1GE6 A;  1XUR A;  1B8Y A;  3I7I A;  1CXV A;  3I7G A;  3EWJ A;  1C7K A;  1HFC A;  3Q2G A;  4G9L A;  3EDG A;  1R55 A;  3VI1 A;  1KUI A;  2K2G A;  3B92 A;  1CIZ A;  3G5C A;  2ERO A;  1D5J A;  3V96 B;  1GO7 P;  3G42 A;  5D1T A;  1WNI A;  1YOU A;  1ZXC A;  2O36 A;  1G9K A;  1ZP5 A;  1OM6 A;  1XFX A;  1ZTQ A;  2HU6 A;  4WKI A;  1BKC I;  1EAK A;  4GWN A;  1USN A;  4IUW A;  5H8X A;  2QPJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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