4WKEA

Crystal structure of human adamts-4 in complex with inhibitor 5-chloro-n-{[(4r)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
214
Chain Sequence
LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
pubmed doi rcsb
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 71
structure length 214
sequence length 220
ec nomenclature ec 3.4.24.82: ADAMTS-4 endopeptidase.
pdb deposition date 2014-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4wkeA00
1UTTA 2DDFA 3KEKA 2Z2DA 1GO8P 3OHOA 3EDIA 4J4MA 4QKZA 2Y6CA 3HBVP 1ATLA 1JH1A 2QPJA 3LJTA 4JQGA 1HFSA 1ROSA 3B2ZA 1CGLA 2KRJA 1ZTQA 4GUYA 4GF1A 2RJPA 2DDYA 1BKCA 4G0DA 1QUAA 4GQLA 3EHYA 1QJIA 4H1QA 3U1RA 4PKTA 5I43A 1DMTA 1RMZA 3WV2A 3HBUP 2O3EA 4H2EA 2MLSA 1QIAA 1ND1A 1UEAA 1USNA 1G4KA 1ZXVA 4JPAA 2W0DA 1KUIA 1SU3A 5I0LA 5JMYA 1D8FA 4PKUA 4AYKA 1I76A 1D8MA 1R1HA 5B5PA 1XUCA 3WV3A 3AYKA 1GXDA 2I47A 3EHXA 4G9LA 3F18A 3LE9A 2J0TA 2OW0A 2WO8A 4R3VA 4FXYP 4H82A 1SMPA 3HDBA 2W14A 1SRPA 2JSDA 3VTGA 1FBLA 1BZSA 3E8RA 1WNIA 3TS4A 5I12A 3LJZA 1UTZA 1DTHA 4ILWD 4L19A 4AXQA 3LUMA 3KHIA 1HFCA 2XS3A 3EDZA 3F15A 456CA 1B3DA 2L0RA 5I3MA 4H49A 3HB2P 3EDGA 2OZRA 3KMEA 3V96B 3G42A 1GE7A 1BUVM 1K7GA 3NX7A 2JIHA 3TVCA 3LMCA 2OY2A 5CUHA 1MNCA 4XM6A 3B8ZA 2X7MA 4XM7A 1QJJA 1ZXCA 3GBOA 2WO9A 2OXWA 2USNA 3Q2GA 1HOVA 1OMJA 1R1IA 3OHLA 2CLTA 2W13A 4XBHA 1MMPA 4GR0A 4WF6A 1Y0VA 3BA0A 1UMTA 1CIZA 3L0TA 1G12A 4GWMA 4ZR5A 1RM8A 1XFXA 4WK7A 1C7KA 4EFSA 1AYKA 3VI1A 1J7NA 3LGPA 4GR8A 2E2DA 1OS2A 1CAQA 4PKSA 4Q1LA 3G5CA 2CKIA 3N2VA 3KWVC 1AKLA 2HU6A 1OO9A 1KBCA 1IAEA 4FVLA 1QIBA 3TT4A 1BUDA 2SRTA 3LIKA 2OVXA 2K2GA 2RJQA 5B5OA 4H84A 1KUKA 4DF9A 1BQOA 3ZXHA 2X3BA 1OM6A 1CGEA 2J83A 2MLRA 3DL1A 4JIJA 4WKEA 1YCMA 1JKYA 4H3XA 2O36A 3O64A 4PKQA 3F16A 1EUBA 5D2BA 1G9KA 1S4BP 2W12A 3I7GA 4CTHA 3ELMA 3KRYA 3O2XA 2OI0A 2K9CA 3DPFA 1O0QA 1SLNA 1HY7A 1Q3AA 1I1IP 2TCLA 1XFWA 3LQBA 2MZIA 4H76A 1K7IA 1BIWA 1BSWA 2X3CA 2PJTA 4IUWA 3HY9A 1PWUA 5I2ZA 1GO7P 4PKVA 1XUDA 3USNA 5LABA 5BOTA 2YIGA 4PKWA 1KUFA 1XFUA 2ERPA 1ZS0A 1JK3A 1G49A 1XFYA 4GWNA 1ZVXA 4I03A 3I7IA 1A86A 3EDHA 3LILA 3LQ0A 1AF0A 2E3XA 1GE5A 1Z3JA 5D7WA 1MMBA 2AYKA 5CXAA 3ZUKA 3HYGA 5L79A 3CKIA 1JIWP 3LJGA 1IAAA 3K7LA 1R1JA 2X3AA 5BPAA 2V4BA 1JANA 3LKAA 1K7QA 1SLMA 1PWVA 2A8HA 4IJOA 1SATA 1FLSA 1JJ9A 1GKCA 2OW2A 1HV5A 5BOYA 1EB6A 1C3IA 1IACA 1C8TA 2JT5A 4H30A 4DPEA 4L63A 2WOAA 1XURA 5D1SA 4DD8A 2MZEA 2YB9A 1KUGA 3B92A 2D1NA 1QICA 2DW1A 2Y6DA 3TSKA 1PWPA 4ON1A 1XFVA 3DSLA 1GKDA 2D1OA 3P1VA 1JIZA 4JA1A 2DW2A 2ERQA 1KUHA 1B8YA 1I73A 1IABA 3P24A 2OY4A 1YQYA 3LK8A 3RTSA 2OVZA 1BM6A 3HY7A 5CZMA 2OXUA 830CA 3DWBA 2OW9A 1CQRA 1O0TA 1EAKA 4JP4A 1R55A 3AYUA 2POJA 3LUNA 3L0VA 3K7NA 1A85A 1OM7A 2FV9A 4WZVA 3F1AA 1XFZA 1MMRA 4AIGA 2AIGP 3SHIA 3LIRA 3ZVSA 4AUOA 1OS9A 3MA2A 5D1TA 966CA 1YP1A 1Y93A 1L6JA 3EWJA 5H8XA 1G05A 2JNPA 4A3WA 1JAQA 1OM8A 1JAOA 1BKCE 1JAPA 1YOUA 1ZP5A 3AIGA 1GE6A 1Y8JA 2MZHA 2W15A 1KAPP 1PWQA 3Q2HA 1R54A 1BQQM 2JT6A 1CXVA 1BKCI 2EROA 1D5JA 3F17A 5D3CA 4DV8A 4FU4A 4FXQA 1D7XA 2XS4A 1CK7A 4XM8A 1H71P 1IAGA 3KMCA 3F19A 2OW1A 5D1UA 4HX3A 4XCTA 5L7FA 1PWWA 3UVCA 1FM1A 5I4OA 1UMSA 3N2UA 4PKRA 2FV5A 2OXZA 2DW0A 3HDAP 4A7BA 3KECA 3LEAA 2N8RA 1CGFA 4WKIA 3DPEA 4IN9A 4HMAA 3RTTA 1HTDA 3KEJA 4GR3A 3WV1A 1ASTA 4I35A 1IADA 1MMQA 4L6TA 3DNGA
chains in the Genus database with same CATH superfamily
1UTTA 2DDFA 3KEKA 2Z2DA 1GO8P 3OHOA 3EDIA 4J4MA 4QKZA 2Y6CA 3HBVP 1ATLA 1JH1A 2QPJA 3LJTA 4JQGA 1HFSA 1ROSA 3B2ZA 1CGLA 2KRJA 1ZTQA 4GUYA 4GF1A 2RJPA 2DDYA 1BKCA 4G0DA 1QUAA 4GQLA 3EHYA 1QJIA 4H1QA 3U1RA 4PKTA 5I43A 1DMTA 1RMZA 3WV2A 3HBUP 2O3EA 4H2EA 2MLSA 1QIAA 1ND1A 1UEAA 1USNA 1G4KA 1ZXVA 4JPAA 2W0DA 1KUIA 1SU3A 5I0LA 5JMYA 1D8FA 4PKUA 4AYKA 1I76A 1D8MA 1R1HA 5B5PA 1XUCA 3WV3A 3AYKA 1GXDA 2I47A 3EHXA 4G9LA 3F18A 3LE9A 2J0TA 2OW0A 2WO8A 4R3VA 4FXYP 4H82A 1SMPA 3HDBA 2W14A 1SRPA 2JSDA 3VTGA 1FBLA 1BZSA 3E8RA 1WNIA 3TS4A 5I12A 3LJZA 1UTZA 1DTHA 4ILWD 4L19A 4AXQA 3LUMA 3KHIA 1HFCA 2XS3A 3EDZA 3F15A 456CA 1B3DA 2L0RA 5I3MA 4H49A 3HB2P 3EDGA 2OZRA 3KMEA 3V96B 3G42A 1GE7A 1BUVM 1K7GA 3NX7A 2JIHA 3TVCA 3LMCA 2OY2A 5CUHA 1MNCA 4XM6A 3B8ZA 2X7MA 4XM7A 1QJJA 1ZXCA 3GBOA 2WO9A 2OXWA 2USNA 3Q2GA 1HOVA 1OMJA 1R1IA 3OHLA 2CLTA 2YUFA 2W13A 4XBHA 1MMPA 4GR0A 4WF6A 1Y0VA 3BA0A 1UMTA 1CIZA 3L0TA 1G12A 4GWMA 4ZR5A 1RM8A 1XFXA 4WK7A 1C7KA 4EFSA 1AYKA 3VI1A 1J7NA 3LGPA 4GR8A 2E2DA 1OS2A 1CAQA 4PKSA 3DTEA 4Q1LA 3G5CA 2CKIA 3N2VA 3KWVC 1AKLA 2HU6A 1OO9A 1KBCA 1IAEA 4FVLA 1QIBA 3TT4A 1BUDA 2SRTA 3LIKA 2OVXA 2K2GA 2RJQA 5B5OA 4H84A 1KUKA 4DF9A 1BQOA 3ZXHA 2X3BA 1OM6A 1CGEA 2J83A 2MLRA 3DL1A 4JIJA 4WKEA 1YCMA 1JKYA 4H3XA 2O36A 3O64A 1XM5A 4PKQA 3F16A 1EUBA 5D2BA 1G9KA 1S4BP 2W12A 3I7GA 4CTHA 3ELMA 3KRYA 3O2XA 2OI0A 2K9CA 3DPFA 1O0QA 1SLNA 1HY7A 1Q3AA 1I1IP 2TCLA 1OZ9A 1XFWA 3LQBA 2MZIA 3DTIA 4H76A 1K7IA 1BIWA 1BSWA 2X3CA 2PJTA 4IUWA 3HY9A 1PWUA 5I2ZA 1GO7P 4PKVA 1XUDA 3USNA 5LABA 5BOTA 2YIGA 4PKWA 1KUFA 1XFUA 2ERPA 1ZS0A 1JK3A 1G49A 1XFYA 4GWNA 1ZVXA 4I03A 3I7IA 1A86A 3EDHA 3LILA 3LQ0A 1AF0A 2E3XA 1GE5A 1Z3JA 5D7WA 1MMBA 2AYKA 5CXAA 3ZUKA 3HYGA 5L79A 3CKIA 1JIWP 3LJGA 1IAAA 3K7LA 1R1JA 2X3AA 5BPAA 2V4BA 1JANA 3LKAA 1K7QA 1SLMA 1PWVA 2A8HA 4IJOA 1SATA 1FLSA 1JJ9A 1GKCA 2OW2A 1HV5A 5BOYA 1EB6A 1C3IA 1IACA 1C8TA 2JT5A 4H30A 4DPEA 4L63A 2WOAA 1XURA 5D1SA 4DD8A 2MZEA 2YB9A 1KUGA 3DTKA 3B92A 2D1NA 1QICA 2DW1A 2Y6DA 3TSKA 1PWPA 4ON1A 1XFVA 3DSLA 1GKDA 2D1OA 3P1VA 1JIZA 4JA1A 2DW2A 2ERQA 1KUHA 1B8YA 1I73A 1IABA 3P24A 2OY4A 1YQYA 3LK8A 3RTSA 2OVZA 1BM6A 3HY7A 5CZMA 2OXUA 830CA 3DWBA 2OW9A 1CQRA 1O0TA 1EAKA 4JP4A 1R55A 3AYUA 2POJA 3LUNA 3L0VA 3K7NA 1A85A 1OM7A 2FV9A 4WZVA 3F1AA 1XFZA 1MMRA 4AIGA 2AIGP 3SHIA 3LIRA 3ZVSA 4AUOA 1OS9A 3MA2A 5D1TA 966CA 1YP1A 1Y93A 4L7AA 1L6JA 3EWJA 5H8XA 1G05A 2JNPA 4A3WA 1JAQA 1OM8A 1JAOA 1BKCE 1JAPA 1YOUA 1ZP5A 3AIGA 1GE6A 1Y8JA 2MZHA 2W15A 1KAPP 1PWQA 3Q2HA 1XAXA 1R54A 1BQQM 2JT6A 1TVIA 1CXVA 1BKCI 2EROA 1D5JA 3F17A 5D3CA 4DV8A 4FU4A 4FXQA 1D7XA 2XS4A 1CK7A 4XM8A 1H71P 1IAGA 3KMCA 3F19A 2OW1A 5D1UA 4HX3A 4XCTA 5L7FA 1PWWA 3UVCA 1FM1A 5I4OA 1UMSA 3N2UA 4PKRA 2FV5A 2OXZA 2DW0A 3HDAP 4A7BA 3KECA 3LEAA 2N8RA 1CGFA 4WKIA 3DPEA 4IN9A 4HMAA 3RTTA 1HTDA 3KEJA 4GR3A 3WV1A 1ASTA 4I35A 1IADA 1MMQA 4L6TA 3DNGA
chains in the Genus database with same CATH topology
1UTTA 2DDFA 3KEKA 2Z2DA 1GO8P 3OHOA 3EDIA 4J4MA 4QKZA 2Y6CA 3HBVP 1ATLA 1JH1A 2QPJA 3LJTA 4JQGA 1HFSA 1ROSA 3B2ZA 1CGLA 2KRJA 1ZTQA 4GUYA 4GF1A 2RJPA 2DDYA 1BKCA 4G0DA 1QUAA 4GQLA 3EHYA 1QJIA 4H1QA 3U1RA 4PKTA 5I43A 1DMTA 1RMZA 3WV2A 3HBUP 2O3EA 4H2EA 2MLSA 1QIAA 1ND1A 1UEAA 1USNA 1G4KA 1ZXVA 4JPAA 2W0DA 1KUIA 1SU3A 5I0LA 5JMYA 1D8FA 4PKUA 4AYKA 1I76A 1D8MA 1R1HA 5B5PA 1XUCA 3WV3A 3AYKA 1GXDA 2I47A 3EHXA 4G9LA 3F18A 3LE9A 2J0TA 2OW0A 2WO8A 4R3VA 4FXYP 4H82A 1SMPA 3HDBA 2W14A 1SRPA 2JSDA 3VTGA 1FBLA 1BZSA 3E8RA 1WNIA 3TS4A 5I12A 3LJZA 1UTZA 1DTHA 4ILWD 4L19A 4AXQA 3LUMA 3KHIA 1HFCA 2XS3A 3EDZA 3F15A 456CA 1B3DA 2L0RA 5I3MA 4H49A 3HB2P 3EDGA 2OZRA 3KMEA 3V96B 3G42A 1GE7A 1BUVM 1K7GA 3NX7A 2JIHA 3TVCA 3LMCA 2OY2A 5CUHA 1MNCA 4XM6A 3B8ZA 2X7MA 4XM7A 1QJJA 1ZXCA 3GBOA 2WO9A 2OXWA 2USNA 3Q2GA 1HOVA 1OMJA 1R1IA 3OHLA 2CLTA 2YUFA 2W13A 4XBHA 1MMPA 4GR0A 4WF6A 1Y0VA 3BA0A 1UMTA 1CIZA 3L0TA 1G12A 4GWMA 4ZR5A 1RM8A 1XFXA 4WK7A 1C7KA 4EFSA 1AYKA 3VI1A 1J7NA 3LGPA 4GR8A 2E2DA 1OS2A 1CAQA 4PKSA 3DTEA 4Q1LA 3G5CA 2CKIA 3N2VA 3KWVC 1AKLA 2HU6A 1OO9A 1KBCA 1IAEA 4FVLA 1QIBA 3TT4A 1BUDA 2SRTA 3LIKA 2OVXA 2K2GA 2RJQA 5B5OA 4H84A 1KUKA 4DF9A 1BQOA 3ZXHA 2X3BA 1OM6A 1CGEA 2J83A 2MLRA 3DL1A 4JIJA 4WKEA 1YCMA 1JKYA 4H3XA 2O36A 3O64A 4PKQA 3F16A 1EUBA 5D2BA 1G9KA 1S4BP 2W12A 3I7GA 4CTHA 3ELMA 3KRYA 3O2XA 2OI0A 2K9CA 3DPFA 1O0QA 1SLNA 1HY7A 1Q3AA 1I1IP 2TCLA 1XFWA 3LQBA 2MZIA 3DTIA 4H76A 1K7IA 1BIWA 1BSWA 2X3CA 2PJTA 4IUWA 3HY9A 1PWUA 5I2ZA 1GO7P 4PKVA 1XUDA 3USNA 5LABA 5BOTA 2YIGA 4PKWA 1KUFA 1XFUA 2ERPA 1ZS0A 1JK3A 1G49A 1XFYA 4GWNA 1ZVXA 4I03A 3I7IA 1A86A 3EDHA 3LILA 3LQ0A 1AF0A 2E3XA 1GE5A 1Z3JA 5D7WA 1MMBA 2AYKA 5CXAA 3ZUKA 3HYGA 5L79A 3CKIA 1JIWP 3LJGA 1IAAA 3K7LA 1R1JA 2X3AA 5BPAA 2V4BA 1JANA 3LKAA 1K7QA 1SLMA 1PWVA 2A8HA 4IJOA 1SATA 1FLSA 1JJ9A 1GKCA 2OW2A 1HV5A 5BOYA 1EB6A 1C3IA 1IACA 1C8TA 2JT5A 4H30A 4DPEA 4L63A 2WOAA 1XURA 5D1SA 4DD8A 2MZEA 2YB9A 1KUGA 3DTKA 3B92A 2D1NA 1QICA 2DW1A 2Y6DA 3TSKA 1PWPA 4ON1A 1XFVA 3DSLA 1GKDA 2D1OA 3P1VA 1JIZA 4JA1A 2DW2A 2ERQA 1KUHA 1B8YA 1I73A 1IABA 3P24A 2OY4A 1YQYA 3LK8A 3RTSA 2OVZA 1BM6A 3HY7A 5CZMA 2OXUA 830CA 3DWBA 2OW9A 1CQRA 1O0TA 1EAKA 4JP4A 1R55A 3AYUA 2POJA 3LUNA 3L0VA 3K7NA 1A85A 1OM7A 2FV9A 4WZVA 3F1AA 1XFZA 1MMRA 4AIGA 2AIGP 3SHIA 3LIRA 3ZVSA 4AUOA 1OS9A 3MA2A 5D1TA 966CA 1YP1A 1Y93A 4L7AA 1L6JA 3EWJA 5H8XA 1G05A 2JNPA 4A3WA 1JAQA 1OM8A 1JAOA 1BKCE 1JAPA 1YOUA 1ZP5A 3AIGA 1GE6A 1Y8JA 2MZHA 2W15A 1KAPP 1PWQA 3Q2HA 1R54A 1BQQM 2JT6A 1CXVA 1BKCI 2EROA 1D5JA 3F17A 5D3CA 4DV8A 4FU4A 4FXQA 1D7XA 2XS4A 1CK7A 4XM8A 1H71P 1IAGA 3KMCA 3F19A 2OW1A 5D1UA 4HX3A 4XCTA 5L7FA 1PWWA 3UVCA 1FM1A 5I4OA 1UMSA 3N2UA 4PKRA 2FV5A 2OXZA 2DW0A 3HDAP 4A7BA 3KECA 3LEAA 2N8RA 1CGFA 4WKIA 3DPEA 4IN9A 4HMAA 3RTTA 1HTDA 3KEJA 4GR3A 3WV1A 1ASTA 4I35A 1IADA 1MMQA 4L6TA 3DNGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UTT A;  2DDF A;  3KEK A;  2Z2D A;  1GO8 P;  3OHO A;  3EDI A;  4J4M A;  4QKZ A;  2Y6C A;  3HBV P;  1ATL A;  1JH1 A;  2QPJ A;  3LJT A;  4JQG A;  1HFS A;  1ROS A;  3B2Z A;  1CGL A;  2KRJ A;  1ZTQ A;  4GUY A;  4GF1 A;  2RJP A;  2DDY A;  1BKC A;  4G0D A;  1QUA A;  4GQL A;  3EHY A;  1QJI A;  4H1Q A;  3U1R A;  4PKT A;  5I43 A;  1DMT A;  1RMZ A;  3WV2 A;  3HBU P;  2O3E A;  4H2E A;  2MLS A;  1QIA A;  1ND1 A;  1UEA A;  1USN A;  1G4K A;  1ZXV A;  4JPA A;  2W0D A;  1KUI A;  1SU3 A;  5I0L A;  5JMY A;  1D8F A;  4PKU A;  4AYK A;  1I76 A;  1D8M A;  1R1H A;  5B5P A;  1XUC A;  3WV3 A;  3AYK A;  1GXD A;  2I47 A;  3EHX A;  4G9L A;  3F18 A;  3LE9 A;  2J0T A;  2OW0 A;  2WO8 A;  4R3V A;  4FXY P;  4H82 A;  1SMP A;  3HDB A;  2W14 A;  1SRP A;  2JSD A;  3VTG A;  1FBL A;  1BZS A;  3E8R A;  1WNI A;  3TS4 A;  5I12 A;  3LJZ A;  1UTZ A;  1DTH A;  4ILW D;  4L19 A;  4AXQ A;  3LUM A;  3KHI A;  1HFC A;  2XS3 A;  3EDZ A;  3F15 A;  456C A;  1B3D A;  2L0R A;  5I3M A;  4H49 A;  3HB2 P;  3EDG A;  2OZR A;  3KME A;  3V96 B;  3G42 A;  1GE7 A;  1BUV M;  1K7G A;  3NX7 A;  2JIH A;  3TVC A;  3LMC A;  2OY2 A;  5CUH A;  1MNC A;  4XM6 A;  3B8Z A;  2X7M A;  4XM7 A;  1QJJ A;  1ZXC A;  3GBO A;  2WO9 A;  2OXW A;  2USN A;  3Q2G A;  1HOV A;  1OMJ A;  1R1I A;  3OHL A;  2CLT A;  2W13 A;  4XBH A;  1MMP A;  4GR0 A;  4WF6 A;  1Y0V A;  3BA0 A;  1UMT A;  1CIZ A;  3L0T A;  1G12 A;  4GWM A;  4ZR5 A;  1RM8 A;  1XFX A;  4WK7 A;  1C7K A;  4EFS A;  1AYK A;  3VI1 A;  1J7N A;  3LGP A;  4GR8 A;  2E2D A;  1OS2 A;  1CAQ A;  4PKS A;  4Q1L A;  3G5C A;  2CKI A;  3N2V A;  3KWV C;  1AKL A;  2HU6 A;  1OO9 A;  1KBC A;  1IAE A;  4FVL A;  1QIB A;  3TT4 A;  1BUD A;  2SRT A;  3LIK A;  2OVX A;  2K2G A;  2RJQ A;  5B5O A;  4H84 A;  1KUK A;  4DF9 A;  1BQO A;  3ZXH A;  2X3B A;  1OM6 A;  1CGE A;  2J83 A;  2MLR A;  3DL1 A;  4JIJ A;  4WKE A;  1YCM A;  1JKY A;  4H3X A;  2O36 A;  3O64 A;  4PKQ A;  3F16 A;  1EUB A;  5D2B A;  1G9K A;  1S4B P;  2W12 A;  3I7G A;  4CTH A;  3ELM A;  3KRY A;  3O2X A;  2OI0 A;  2K9C A;  3DPF A;  1O0Q A;  1SLN A;  1HY7 A;  1Q3A A;  1I1I P;  2TCL A;  1XFW A;  3LQB A;  2MZI A;  4H76 A;  1K7I A;  1BIW A;  1BSW A;  2X3C A;  2PJT A;  4IUW A;  3HY9 A;  1PWU A;  5I2Z A;  1GO7 P;  4PKV A;  1XUD A;  3USN A;  5LAB A;  5BOT A;  2YIG A;  4PKW A;  1KUF A;  1XFU A;  2ERP A;  1ZS0 A;  1JK3 A;  1G49 A;  1XFY A;  4GWN A;  1ZVX A;  4I03 A;  3I7I A;  1A86 A;  3EDH A;  3LIL A;  3LQ0 A;  1AF0 A;  2E3X A;  1GE5 A;  1Z3J A;  5D7W A;  1MMB A;  2AYK A;  5CXA A;  3ZUK A;  3HYG A;  5L79 A;  3CKI A;  1JIW P;  3LJG A;  1IAA A;  3K7L A;  1R1J A;  2X3A A;  5BPA A;  2V4B A;  1JAN A;  3LKA A;  1K7Q A;  1SLM A;  1PWV A;  2A8H A;  4IJO A;  1SAT A;  1FLS A;  1JJ9 A;  1GKC A;  2OW2 A;  1HV5 A;  5BOY A;  1EB6 A;  1C3I A;  1IAC A;  1C8T A;  2JT5 A;  4H30 A;  4DPE A;  4L63 A;  2WOA A;  1XUR A;  5D1S A;  4DD8 A;  2MZE A;  2YB9 A;  1KUG A;  3B92 A;  2D1N A;  1QIC A;  2DW1 A;  2Y6D A;  3TSK A;  1PWP A;  4ON1 A;  1XFV A;  3DSL A;  1GKD A;  2D1O A;  3P1V A;  1JIZ A;  4JA1 A;  2DW2 A;  2ERQ A;  1KUH A;  1B8Y A;  1I73 A;  1IAB A;  3P24 A;  2OY4 A;  1YQY A;  3LK8 A;  3RTS A;  2OVZ A;  1BM6 A;  3HY7 A;  5CZM A;  2OXU A;  830C A;  3DWB A;  2OW9 A;  1CQR A;  1O0T A;  1EAK A;  4JP4 A;  1R55 A;  3AYU A;  2POJ A;  3LUN A;  3L0V A;  3K7N A;  1A85 A;  1OM7 A;  2FV9 A;  4WZV A;  3F1A A;  1XFZ A;  1MMR A;  4AIG A;  2AIG P;  3SHI A;  3LIR A;  3ZVS A;  4AUO A;  1OS9 A;  3MA2 A;  5D1T A;  966C A;  1YP1 A;  1Y93 A;  1L6J A;  3EWJ A;  5H8X A;  1G05 A;  2JNP A;  4A3W A;  1JAQ A;  1OM8 A;  1JAO A;  1BKC E;  1JAP A;  1YOU A;  1ZP5 A;  3AIG A;  1GE6 A;  1Y8J A;  2MZH A;  2W15 A;  1KAP P;  1PWQ A;  3Q2H A;  1R54 A;  1BQQ M;  2JT6 A;  1CXV A;  1BKC I;  2ERO A;  1D5J A;  3F17 A;  5D3C A;  4DV8 A;  4FU4 A;  4FXQ A;  1D7X A;  2XS4 A;  1CK7 A;  4XM8 A;  1H71 P;  1IAG A;  3KMC A;  3F19 A;  2OW1 A;  5D1U A;  4HX3 A;  4XCT A;  5L7F A;  1PWW A;  3UVC A;  1FM1 A;  5I4O A;  1UMS A;  3N2U A;  4PKR A;  2FV5 A;  2OXZ A;  2DW0 A;  3HDA P;  4A7B A;  3KEC A;  3LEA A;  2N8R A;  1CGF A;  4WKI A;  3DPE A;  4IN9 A;  4HMA A;  3RTT A;  1HTD A;  3KEJ A;  4GR3 A;  3WV1 A;  1AST A;  4I35 A;  1IAD A;  1MMQ A;  4L6T A;  3DNG A; 
#chains in the Genus database with same CATH topology
 1UTT A;  2DDF A;  3KEK A;  2Z2D A;  1GO8 P;  3OHO A;  3EDI A;  4J4M A;  4QKZ A;  2Y6C A;  3HBV P;  1ATL A;  1JH1 A;  2QPJ A;  3LJT A;  4JQG A;  1HFS A;  1ROS A;  3B2Z A;  1CGL A;  2KRJ A;  1ZTQ A;  4GUY A;  4GF1 A;  2RJP A;  2DDY A;  1BKC A;  4G0D A;  1QUA A;  4GQL A;  3EHY A;  1QJI A;  4H1Q A;  3U1R A;  4PKT A;  5I43 A;  1DMT A;  1RMZ A;  3WV2 A;  3HBU P;  2O3E A;  4H2E A;  2MLS A;  1QIA A;  1ND1 A;  1UEA A;  1USN A;  1G4K A;  1ZXV A;  4JPA A;  2W0D A;  1KUI A;  1SU3 A;  5I0L A;  5JMY A;  1D8F A;  4PKU A;  4AYK A;  1I76 A;  1D8M A;  1R1H A;  5B5P A;  1XUC A;  3WV3 A;  3AYK A;  1GXD A;  2I47 A;  3EHX A;  4G9L A;  3F18 A;  3LE9 A;  2J0T A;  2OW0 A;  2WO8 A;  4R3V A;  4FXY P;  4H82 A;  1SMP A;  3HDB A;  2W14 A;  1SRP A;  2JSD A;  3VTG A;  1FBL A;  1BZS A;  3E8R A;  1WNI A;  3TS4 A;  5I12 A;  3LJZ A;  1UTZ A;  1DTH A;  4ILW D;  4L19 A;  4AXQ A;  3LUM A;  3KHI A;  1HFC A;  2XS3 A;  3EDZ A;  3F15 A;  456C A;  1B3D A;  2L0R A;  5I3M A;  4H49 A;  3HB2 P;  3EDG A;  2OZR A;  3KME A;  3V96 B;  3G42 A;  1GE7 A;  1BUV M;  1K7G A;  3NX7 A;  2JIH A;  3TVC A;  3LMC A;  2OY2 A;  5CUH A;  1MNC A;  4XM6 A;  3B8Z A;  2X7M A;  4XM7 A;  1QJJ A;  1ZXC A;  3GBO A;  2WO9 A;  2OXW A;  2USN A;  3Q2G A;  1HOV A;  1OMJ A;  1R1I A;  3OHL A;  2CLT A;  2YUF A;  2W13 A;  4XBH A;  1MMP A;  4GR0 A;  4WF6 A;  1Y0V A;  3BA0 A;  1UMT A;  1CIZ A;  3L0T A;  1G12 A;  4GWM A;  4ZR5 A;  1RM8 A;  1XFX A;  4WK7 A;  1C7K A;  4EFS A;  1AYK A;  3VI1 A;  1J7N A;  3LGP A;  4GR8 A;  2E2D A;  1OS2 A;  1CAQ A;  4PKS A;  3DTE A;  4Q1L A;  3G5C A;  2CKI A;  3N2V A;  3KWV C;  1AKL A;  2HU6 A;  1OO9 A;  1KBC A;  1IAE A;  4FVL A;  1QIB A;  3TT4 A;  1BUD A;  2SRT A;  3LIK A;  2OVX A;  2K2G A;  2RJQ A;  5B5O A;  4H84 A;  1KUK A;  4DF9 A;  1BQO A;  3ZXH A;  2X3B A;  1OM6 A;  1CGE A;  2J83 A;  2MLR A;  3DL1 A;  4JIJ A;  4WKE A;  1YCM A;  1JKY A;  4H3X A;  2O36 A;  3O64 A;  1XM5 A;  4PKQ A;  3F16 A;  1EUB A;  5D2B A;  1G9K A;  1S4B P;  2W12 A;  3I7G A;  4CTH A;  3ELM A;  3KRY A;  3O2X A;  2OI0 A;  2K9C A;  3DPF A;  1O0Q A;  1SLN A;  1HY7 A;  1Q3A A;  1I1I P;  2TCL A;  1OZ9 A;  1XFW A;  3LQB A;  2MZI A;  3DTI A;  4H76 A;  1K7I A;  1BIW A;  1BSW A;  2X3C A;  2PJT A;  4IUW A;  3HY9 A;  1PWU A;  5I2Z A;  1GO7 P;  4PKV A;  1XUD A;  3USN A;  5LAB A;  5BOT A;  2YIG A;  4PKW A;  1KUF A;  1XFU A;  2ERP A;  1ZS0 A;  1JK3 A;  1G49 A;  1XFY A;  4GWN A;  1ZVX A;  4I03 A;  3I7I A;  1A86 A;  3EDH A;  3LIL A;  3LQ0 A;  1AF0 A;  2E3X A;  1GE5 A;  1Z3J A;  5D7W A;  1MMB A;  2AYK A;  5CXA A;  3ZUK A;  3HYG A;  5L79 A;  3CKI A;  1JIW P;  3LJG A;  1IAA A;  3K7L A;  1R1J A;  2X3A A;  5BPA A;  2V4B A;  1JAN A;  3LKA A;  1K7Q A;  1SLM A;  1PWV A;  2A8H A;  4IJO A;  1SAT A;  1FLS A;  1JJ9 A;  1GKC A;  2OW2 A;  1HV5 A;  5BOY A;  1EB6 A;  1C3I A;  1IAC A;  1C8T A;  2JT5 A;  4H30 A;  4DPE A;  4L63 A;  2WOA A;  1XUR A;  5D1S A;  4DD8 A;  2MZE A;  2YB9 A;  1KUG A;  3DTK A;  3B92 A;  2D1N A;  1QIC A;  2DW1 A;  2Y6D A;  3TSK A;  1PWP A;  4ON1 A;  1XFV A;  3DSL A;  1GKD A;  2D1O A;  3P1V A;  1JIZ A;  4JA1 A;  2DW2 A;  2ERQ A;  1KUH A;  1B8Y A;  1I73 A;  1IAB A;  3P24 A;  2OY4 A;  1YQY A;  3LK8 A;  3RTS A;  2OVZ A;  1BM6 A;  3HY7 A;  5CZM A;  2OXU A;  830C A;  3DWB A;  2OW9 A;  1CQR A;  1O0T A;  1EAK A;  4JP4 A;  1R55 A;  3AYU A;  2POJ A;  3LUN A;  3L0V A;  3K7N A;  1A85 A;  1OM7 A;  2FV9 A;  4WZV A;  3F1A A;  1XFZ A;  1MMR A;  4AIG A;  2AIG P;  3SHI A;  3LIR A;  3ZVS A;  4AUO A;  1OS9 A;  3MA2 A;  5D1T A;  966C A;  1YP1 A;  1Y93 A;  4L7A A;  1L6J A;  3EWJ A;  5H8X A;  1G05 A;  2JNP A;  4A3W A;  1JAQ A;  1OM8 A;  1JAO A;  1BKC E;  1JAP A;  1YOU A;  1ZP5 A;  3AIG A;  1GE6 A;  1Y8J A;  2MZH A;  2W15 A;  1KAP P;  1PWQ A;  3Q2H A;  1XAX A;  1R54 A;  1BQQ M;  2JT6 A;  1TVI A;  1CXV A;  1BKC I;  2ERO A;  1D5J A;  3F17 A;  5D3C A;  4DV8 A;  4FU4 A;  4FXQ A;  1D7X A;  2XS4 A;  1CK7 A;  4XM8 A;  1H71 P;  1IAG A;  3KMC A;  3F19 A;  2OW1 A;  5D1U A;  4HX3 A;  4XCT A;  5L7F A;  1PWW A;  3UVC A;  1FM1 A;  5I4O A;  1UMS A;  3N2U A;  4PKR A;  2FV5 A;  2OXZ A;  2DW0 A;  3HDA P;  4A7B A;  3KEC A;  3LEA A;  2N8R A;  1CGF A;  4WKI A;  3DPE A;  4IN9 A;  4HMA A;  3RTT A;  1HTD A;  3KEJ A;  4GR3 A;  3WV1 A;  1AST A;  4I35 A;  1IAD A;  1MMQ A;  4L6T A;  3DNG A; 
#chains in the Genus database with same CATH homology
 1UTT A;  2DDF A;  3KEK A;  2Z2D A;  1GO8 P;  3OHO A;  3EDI A;  4J4M A;  4QKZ A;  2Y6C A;  3HBV P;  1ATL A;  1JH1 A;  2QPJ A;  3LJT A;  4JQG A;  1HFS A;  1ROS A;  3B2Z A;  1CGL A;  2KRJ A;  1ZTQ A;  4GUY A;  4GF1 A;  2RJP A;  2DDY A;  1BKC A;  4G0D A;  1QUA A;  4GQL A;  3EHY A;  1QJI A;  4H1Q A;  3U1R A;  4PKT A;  5I43 A;  1DMT A;  1RMZ A;  3WV2 A;  3HBU P;  2O3E A;  4H2E A;  2MLS A;  1QIA A;  1ND1 A;  1UEA A;  1USN A;  1G4K A;  1ZXV A;  4JPA A;  2W0D A;  1KUI A;  1SU3 A;  5I0L A;  5JMY A;  1D8F A;  4PKU A;  4AYK A;  1I76 A;  1D8M A;  1R1H A;  5B5P A;  1XUC A;  3WV3 A;  3AYK A;  1GXD A;  2I47 A;  3EHX A;  4G9L A;  3F18 A;  3LE9 A;  2J0T A;  2OW0 A;  2WO8 A;  4R3V A;  4FXY P;  4H82 A;  1SMP A;  3HDB A;  2W14 A;  1SRP A;  2JSD A;  3VTG A;  1FBL A;  1BZS A;  3E8R A;  1WNI A;  3TS4 A;  5I12 A;  3LJZ A;  1UTZ A;  1DTH A;  4ILW D;  4L19 A;  4AXQ A;  3LUM A;  3KHI A;  1HFC A;  2XS3 A;  3EDZ A;  3F15 A;  456C A;  1B3D A;  2L0R A;  5I3M A;  4H49 A;  3HB2 P;  3EDG A;  2OZR A;  3KME A;  3V96 B;  3G42 A;  1GE7 A;  1BUV M;  1K7G A;  3NX7 A;  2JIH A;  3TVC A;  3LMC A;  2OY2 A;  5CUH A;  1MNC A;  4XM6 A;  3B8Z A;  2X7M A;  4XM7 A;  1QJJ A;  1ZXC A;  3GBO A;  2WO9 A;  2OXW A;  2USN A;  3Q2G A;  1HOV A;  1OMJ A;  1R1I A;  3OHL A;  2CLT A;  2YUF A;  2W13 A;  4XBH A;  1MMP A;  4GR0 A;  4WF6 A;  1Y0V A;  3BA0 A;  1UMT A;  1CIZ A;  3L0T A;  1G12 A;  4GWM A;  4ZR5 A;  1RM8 A;  1XFX A;  4WK7 A;  1C7K A;  4EFS A;  1AYK A;  3VI1 A;  1J7N A;  3LGP A;  4GR8 A;  2E2D A;  1OS2 A;  1CAQ A;  4PKS A;  3DTE A;  4Q1L A;  3G5C A;  2CKI A;  3N2V A;  3KWV C;  1AKL A;  2HU6 A;  1OO9 A;  1KBC A;  1IAE A;  4FVL A;  1QIB A;  3TT4 A;  1BUD A;  2SRT A;  3LIK A;  2OVX A;  2K2G A;  2RJQ A;  5B5O A;  4H84 A;  1KUK A;  4DF9 A;  1BQO A;  3ZXH A;  2X3B A;  1OM6 A;  1CGE A;  2J83 A;  2MLR A;  3DL1 A;  4JIJ A;  4WKE A;  1YCM A;  1JKY A;  4H3X A;  2O36 A;  3O64 A;  4PKQ A;  3F16 A;  1EUB A;  5D2B A;  1G9K A;  1S4B P;  2W12 A;  3I7G A;  4CTH A;  3ELM A;  3KRY A;  3O2X A;  2OI0 A;  2K9C A;  3DPF A;  1O0Q A;  1SLN A;  1HY7 A;  1Q3A A;  1I1I P;  2TCL A;  1XFW A;  3LQB A;  2MZI A;  3DTI A;  4H76 A;  1K7I A;  1BIW A;  1BSW A;  2X3C A;  2PJT A;  4IUW A;  3HY9 A;  1PWU A;  5I2Z A;  1GO7 P;  4PKV A;  1XUD A;  3USN A;  5LAB A;  5BOT A;  2YIG A;  4PKW A;  1KUF A;  1XFU A;  2ERP A;  1ZS0 A;  1JK3 A;  1G49 A;  1XFY A;  4GWN A;  1ZVX A;  4I03 A;  3I7I A;  1A86 A;  3EDH A;  3LIL A;  3LQ0 A;  1AF0 A;  2E3X A;  1GE5 A;  1Z3J A;  5D7W A;  1MMB A;  2AYK A;  5CXA A;  3ZUK A;  3HYG A;  5L79 A;  3CKI A;  1JIW P;  3LJG A;  1IAA A;  3K7L A;  1R1J A;  2X3A A;  5BPA A;  2V4B A;  1JAN A;  3LKA A;  1K7Q A;  1SLM A;  1PWV A;  2A8H A;  4IJO A;  1SAT A;  1FLS A;  1JJ9 A;  1GKC A;  2OW2 A;  1HV5 A;  5BOY A;  1EB6 A;  1C3I A;  1IAC A;  1C8T A;  2JT5 A;  4H30 A;  4DPE A;  4L63 A;  2WOA A;  1XUR A;  5D1S A;  4DD8 A;  2MZE A;  2YB9 A;  1KUG A;  3DTK A;  3B92 A;  2D1N A;  1QIC A;  2DW1 A;  2Y6D A;  3TSK A;  1PWP A;  4ON1 A;  1XFV A;  3DSL A;  1GKD A;  2D1O A;  3P1V A;  1JIZ A;  4JA1 A;  2DW2 A;  2ERQ A;  1KUH A;  1B8Y A;  1I73 A;  1IAB A;  3P24 A;  2OY4 A;  1YQY A;  3LK8 A;  3RTS A;  2OVZ A;  1BM6 A;  3HY7 A;  5CZM A;  2OXU A;  830C A;  3DWB A;  2OW9 A;  1CQR A;  1O0T A;  1EAK A;  4JP4 A;  1R55 A;  3AYU A;  2POJ A;  3LUN A;  3L0V A;  3K7N A;  1A85 A;  1OM7 A;  2FV9 A;  4WZV A;  3F1A A;  1XFZ A;  1MMR A;  4AIG A;  2AIG P;  3SHI A;  3LIR A;  3ZVS A;  4AUO A;  1OS9 A;  3MA2 A;  5D1T A;  966C A;  1YP1 A;  1Y93 A;  4L7A A;  1L6J A;  3EWJ A;  5H8X A;  1G05 A;  2JNP A;  4A3W A;  1JAQ A;  1OM8 A;  1JAO A;  1BKC E;  1JAP A;  1YOU A;  1ZP5 A;  3AIG A;  1GE6 A;  1Y8J A;  2MZH A;  2W15 A;  1KAP P;  1PWQ A;  3Q2H A;  1R54 A;  1BQQ M;  2JT6 A;  1CXV A;  1BKC I;  2ERO A;  1D5J A;  3F17 A;  5D3C A;  4DV8 A;  4FU4 A;  4FXQ A;  1D7X A;  2XS4 A;  1CK7 A;  4XM8 A;  1H71 P;  1IAG A;  3KMC A;  3F19 A;  2OW1 A;  5D1U A;  4HX3 A;  4XCT A;  5L7F A;  1PWW A;  3UVC A;  1FM1 A;  5I4O A;  1UMS A;  3N2U A;  4PKR A;  2FV5 A;  2OXZ A;  2DW0 A;  3HDA P;  4A7B A;  3KEC A;  3LEA A;  2N8R A;  1CGF A;  4WKI A;  3DPE A;  4IN9 A;  4HMA A;  3RTT A;  1HTD A;  3KEJ A;  4GR3 A;  3WV1 A;  1AST A;  4I35 A;  1IAD A;  1MMQ A;  4L6T A;  3DNG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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