4GR3A

Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470a
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
159
structure length
159
Chain Sequence
MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 45
structure length 159
sequence length 159
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2012-08-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4gr3A00
4L6TA 4PKUA 3KRYA 966CA 2RJQA 5I4OA 1XFWA 2D1NA 1R1HA 2DW1A 3N2VA 1BUDA 3KEJA 4DPEA 2D1OA 2K9CA 1OS2A 4H30A 3ZVSA 1SATA 1H71P 3LJZA 4XBHA 1IADA 3HB2P 3RTTA 3AIGA 1O0QA 2N8RA 2OXWA 5I43A 4GR3A 4PKVA 1SU3A 3TVCA 3OHLA 3F17A 2AYKA 5CXAA 1HV5A 5L7FA 1JAPA 1I1IP 1C3IA 1ROSA 4G0DA 1XFVA 5JMYA 830CA 4CTHA 4PKQA 3V96B 1WNIA 1GE5A 1Y8JA 4WF6A 2YB9A 1CAQA 4WZVA 1I76A 3WV1A 4FXQA 1ZTQA 2E3XA 2AIGP 4PKSA 1JAOA 1EAKA 1BIWA 456CA 1AYKA 4DD8A 4AYKA 3TS4A 1BM6A 2W13A 1BKCI 4J4MA 2OW1A 5I12A 1BZSA 3LMCA 1GXDA 4ILWD 1EUBA 4FVLA 2OZRA 4AXQA 5BPAA 3EWJA 2W15A 4H2EA 1CGEA 2X3BA 3LJTA 3NX7A 3DWBA 2DDYA 3N2UA 1JKYA 1XFUA 3Q2HA 1XUDA 4JQGA 1BUVM 3P24A 2XS4A 1XFYA 1KAPP 5D2BA 2MLRA 4I35A 3F16A 3KHIA 2QPJA 3KMEA 4L19A 4G9LA 2OI0A 1MMBA 2OW0A 2I47A 2W0DA 3F18A 1OM8A 1OMJA 1K7IA 1MMQA 3KEKA 1ZP5A 1XFZA 2X7MA 3LIRA 1XURA 2KRJA 4ON1A 3L0TA 1ZXCA 1DMTA 4DV8A 1GO7P 2W14A 4AIGA 2L0RA 2TCLA 1I73A 1MMPA 1OO9A 3EDZA 2J0TA 3LUNA 1BQOA 4GF1A 2OVXA 1FLSA 3ZUKA 4I03A 1YCMA 2JSDA 3U1RA 3B2ZA 1HTDA 3DNGA 1L6JA 3LQBA 4GR0A 1AF0A 3DPEA 1QJJA 1JH1A 3GBOA 2CLTA 2WO9A 1RMZA 3LUMA 1C8TA 4WKIA 4R3VA 1PWUA 2MZEA 1JK3A 3USNA 1EB6A 1QJIA 3TSKA 3K7LA 3CKIA 2SRTA 2FV5A 1Z3JA 2OY4A 3BA0A 3MA2A 2ERQA 1GE6A 3KWVC 1PWPA 2YIGA 1ZS0A 3F15A 3EHXA 5LABA 1BQQM 2JT6A 4GQLA 1UTZA 3DPFA 2Y6CA 3E8RA 1ASTA 4H82A 3OHOA 5I3MA 1G9KA 1ATLA 2MLSA 4XM8A 3LK8A 1KUFA 4XM7A 2W12A 1D8FA 1USNA 1Q3AA 4GUYA 4ZR5A 1D5JA 3HDBA 2J83A 4HMAA 1JAQA 1UMTA 3LQ0A 2WO8A 3LE9A 5CZMA 1R1IA 2OY2A 2X3AA 4DF9A 1DTHA 1OM6A 5B5OA 4FXYP 1R54A 4XCTA 2OW2A 3L0VA 1UMSA 4WKEA 1IAGA 1S4BP 3B92A 2V4BA 1CGLA 1HOVA 2OVZA 1JIWP 5D1UA 3G5CA 1IAEA 2O3EA 5D3CA 2DW0A 1GE7A 3DL1A 5D1TA 1FBLA 1YQYA 1JJ9A 1ZVXA 1HY7A 1SMPA 4QKZA 1G05A 3G42A 1JIZA 1KUHA 1YP1A 1D8MA 1GKCA 3DSLA 4Q1LA 1CXVA 4GWNA 1UTTA 1GO8P 1QICA 1R1JA 1IAAA 3F19A 2DW2A 1IACA 2JNPA 4IJOA 3B8ZA 1SLNA 2X3CA 2ERPA 3AYUA 4H76A 1UEAA 2JT5A 1KUKA 2MZHA 5L79A 3EDHA 1XUCA 4EFSA 3HY9A 1CQRA 1QIAA 2K2GA 1IABA 1RM8A 3VTGA 4A7BA 4PKRA 2XS3A 2POJA 1AKLA 4H84A 5I0LA 2OXUA 2OW9A 1KBCA 2FV9A 3KECA 1YOUA 2OXZA 1JANA 3RTSA 1ZXVA 3HBUP 1C7KA 1SRPA 1B3DA 5BOTA 1QIBA 4JP4A 1PWQA 1CIZA 3LGPA 1K7QA 3K7NA 2PJTA 4PKTA 2USNA 4GR8A 3O2XA 3UVCA 1Y0VA 1A86A 1GKDA 1PWVA 3LILA 1XFXA 4H1QA 3F1AA 1BKCA 2EROA 4HX3A 1BSWA 3HDAP 1OS9A 4IUWA 4IN9A 4H3XA 1G49A 3LIKA 3P1VA 2O36A 3ZXHA 4PKWA 3LKAA 4H49A 3TT4A 2WOAA 5I2ZA 1MMRA 1A85A 1O0TA 3EDIA 1G4KA 1CGFA 1D7XA 3EDGA 1OM7A 1J7NA 5D1SA 1ND1A 3HBVP 3LEAA 1SLMA 5CUHA 1BKCE 1CK7A 2HU6A 1Y93A 1KUIA 5B5PA 3LJGA 4GWMA 3HY7A 1G12A 1R55A 1KUGA 3VI1A 4JPAA 3AYKA 4JA1A 3ELMA 3O64A 3I7IA 1MNCA 2Z2DA 1QUAA 5H8XA 3WV2A 2RJPA 2A8HA 4A3WA 1K7GA 4L63A 4AUOA 2Y6DA 3EHYA 4XM6A 1B8YA 5BOYA 2E2DA 3SHIA 3I7GA 2MZIA 3Q2GA 1HFCA 3WV3A 1FM1A 4FU4A 2JIHA 2CKIA 1PWWA 2DDFA 1HFSA 5D7WA 3HYGA 3KMCA 4JIJA 4WK7A
chains in the Genus database with same CATH superfamily
4L6TA 4PKUA 3KRYA 966CA 2RJQA 5I4OA 1XFWA 2D1NA 1R1HA 2DW1A 3N2VA 1BUDA 3KEJA 4DPEA 2D1OA 2K9CA 1OS2A 4H30A 3ZVSA 1SATA 1H71P 3LJZA 4XBHA 1IADA 3HB2P 3RTTA 3AIGA 1O0QA 2N8RA 2OXWA 5I43A 4GR3A 4PKVA 1SU3A 3TVCA 3OHLA 3F17A 2AYKA 5CXAA 1HV5A 5L7FA 1JAPA 1I1IP 1C3IA 1ROSA 4G0DA 1XFVA 5JMYA 830CA 4CTHA 4PKQA 3V96B 1WNIA 1GE5A 1Y8JA 4WF6A 2YB9A 1CAQA 4WZVA 1I76A 3WV1A 4FXQA 1ZTQA 2E3XA 2AIGP 4PKSA 1JAOA 1EAKA 1BIWA 456CA 1AYKA 4DD8A 4AYKA 3TS4A 1BM6A 2W13A 1BKCI 4J4MA 2OW1A 5I12A 1BZSA 3LMCA 1GXDA 4ILWD 1EUBA 3DTKA 4FVLA 2OZRA 4AXQA 5BPAA 3EWJA 2W15A 4H2EA 1CGEA 2X3BA 3LJTA 1XAXA 3DWBA 2DDYA 3N2UA 1JKYA 3NX7A 1XFUA 3Q2HA 1XUDA 4JQGA 1BUVM 3P24A 2XS4A 1XFYA 1KAPP 5D2BA 2MLRA 4I35A 3F16A 3KHIA 2QPJA 3KMEA 4L19A 4G9LA 2OI0A 1MMBA 2OW0A 2I47A 2W0DA 3F18A 1OM8A 1OMJA 1K7IA 1MMQA 3KEKA 1ZP5A 1XFZA 2X7MA 3LIRA 1XURA 2KRJA 4ON1A 3L0TA 1ZXCA 1DMTA 4DV8A 1GO7P 2W14A 4AIGA 2L0RA 2TCLA 1I73A 1MMPA 1OO9A 3EDZA 2J0TA 3LUNA 1BQOA 4GF1A 2OVXA 1FLSA 3ZUKA 4I03A 1YCMA 2JSDA 3U1RA 3B2ZA 1HTDA 3DNGA 1L6JA 3LQBA 4GR0A 1AF0A 3DPEA 1QJJA 1JH1A 3GBOA 2CLTA 2WO9A 1RMZA 3LUMA 1C8TA 4WKIA 4R3VA 1PWUA 2MZEA 1JK3A 3USNA 1EB6A 1QJIA 3TSKA 3K7LA 3CKIA 2SRTA 2FV5A 1Z3JA 2OY4A 3BA0A 3MA2A 2ERQA 1GE6A 3KWVC 1PWPA 2YIGA 1ZS0A 3F15A 3EHXA 5LABA 1BQQM 2JT6A 4GQLA 1UTZA 3DPFA 2Y6CA 3E8RA 1ASTA 4H82A 3OHOA 5I3MA 1G9KA 1ATLA 2MLSA 4XM8A 3LK8A 1KUFA 4XM7A 2W12A 1D8FA 1USNA 1Q3AA 4GUYA 4ZR5A 1D5JA 3HDBA 2J83A 4HMAA 1JAQA 1UMTA 3LQ0A 2WO8A 3LE9A 5CZMA 1R1IA 2OY2A 2X3AA 4DF9A 1DTHA 1OM6A 5B5OA 4FXYP 1R54A 4XCTA 2OW2A 3L0VA 1UMSA 4WKEA 1IAGA 1S4BP 3B92A 2V4BA 1CGLA 1HOVA 2OVZA 1JIWP 5D1UA 3G5CA 1IAEA 2O3EA 5D3CA 2DW0A 1GE7A 3DL1A 5D1TA 1FBLA 1YQYA 2YUFA 1JJ9A 1ZVXA 1HY7A 1SMPA 4QKZA 1G05A 3G42A 1JIZA 1KUHA 1YP1A 1D8MA 1GKCA 3DSLA 4Q1LA 1CXVA 4GWNA 1UTTA 1GO8P 1QICA 1R1JA 1IAAA 3F19A 2DW2A 1IACA 2JNPA 4IJOA 3B8ZA 1SLNA 2X3CA 2ERPA 3AYUA 4H76A 1UEAA 2JT5A 1KUKA 2MZHA 5L79A 3EDHA 1XUCA 4EFSA 3HY9A 1CQRA 1QIAA 2K2GA 1IABA 1RM8A 3VTGA 1XM5A 4A7BA 4PKRA 2XS3A 2POJA 1AKLA 4H84A 5I0LA 2OXUA 1TVIA 2OW9A 1KBCA 2FV9A 3KECA 1YOUA 2OXZA 1JANA 3RTSA 1ZXVA 3HBUP 1C7KA 1SRPA 1B3DA 5BOTA 1QIBA 4JP4A 1PWQA 1CIZA 3LGPA 1K7QA 3K7NA 2PJTA 4PKTA 2USNA 4GR8A 3O2XA 3UVCA 3DTEA 1Y0VA 1A86A 1GKDA 1PWVA 3LILA 1XFXA 4H1QA 3F1AA 1BKCA 2EROA 4HX3A 1BSWA 3HDAP 1OS9A 4IUWA 4IN9A 4H3XA 1G49A 3LIKA 3P1VA 2O36A 3ZXHA 4PKWA 3LKAA 4H49A 3TT4A 2WOAA 5I2ZA 1MMRA 1A85A 1O0TA 3EDIA 1G4KA 1CGFA 1D7XA 3EDGA 1OM7A 1J7NA 5D1SA 3DTIA 1OZ9A 1ND1A 3HBVP 3LEAA 1SLMA 4L7AA 5CUHA 1BKCE 1CK7A 2HU6A 1Y93A 1KUIA 5B5PA 3LJGA 4GWMA 3HY7A 1G12A 1R55A 1KUGA 3VI1A 4JPAA 3AYKA 4JA1A 3ELMA 3O64A 3I7IA 1MNCA 2Z2DA 1QUAA 5H8XA 3WV2A 2RJPA 2A8HA 4A3WA 1K7GA 4L63A 4AUOA 2Y6DA 3EHYA 4XM6A 1B8YA 5BOYA 2E2DA 3SHIA 3I7GA 2MZIA 3Q2GA 1HFCA 3WV3A 1FM1A 4FU4A 2JIHA 2CKIA 1PWWA 2DDFA 1HFSA 5D7WA 3HYGA 3KMCA 4JIJA 4WK7A
chains in the Genus database with same CATH topology
4L6TA 4PKUA 3KRYA 966CA 2RJQA 5I4OA 1XFWA 2D1NA 1R1HA 2DW1A 3N2VA 1BUDA 3KEJA 4DPEA 2D1OA 2K9CA 1OS2A 4H30A 3ZVSA 1SATA 1H71P 3LJZA 4XBHA 1IADA 3HB2P 3RTTA 3AIGA 1O0QA 2N8RA 2OXWA 5I43A 4GR3A 4PKVA 1SU3A 3TVCA 3OHLA 3F17A 2AYKA 5CXAA 1HV5A 5L7FA 1JAPA 1I1IP 1C3IA 1ROSA 4G0DA 1XFVA 5JMYA 830CA 4CTHA 4PKQA 3V96B 1WNIA 1GE5A 1Y8JA 4WF6A 2YB9A 1CAQA 4WZVA 1I76A 3WV1A 4FXQA 1ZTQA 2E3XA 2AIGP 4PKSA 1JAOA 1EAKA 1BIWA 456CA 1AYKA 4DD8A 4AYKA 3TS4A 1BM6A 2W13A 1BKCI 4J4MA 2OW1A 5I12A 1BZSA 3LMCA 1GXDA 4ILWD 1EUBA 3DTKA 4FVLA 2OZRA 4AXQA 5BPAA 3EWJA 2W15A 4H2EA 1CGEA 2X3BA 3LJTA 3NX7A 3DWBA 2DDYA 3N2UA 1JKYA 1XFUA 3Q2HA 1XUDA 4JQGA 1BUVM 3P24A 2XS4A 1XFYA 1KAPP 5D2BA 2MLRA 4I35A 3F16A 3KHIA 2QPJA 3KMEA 4L19A 4G9LA 2OI0A 1MMBA 2OW0A 2I47A 2W0DA 3F18A 1OM8A 1OMJA 1K7IA 1MMQA 3KEKA 1ZP5A 1XFZA 2X7MA 3LIRA 1XURA 2KRJA 4ON1A 3L0TA 1ZXCA 1DMTA 4DV8A 1GO7P 2W14A 4AIGA 2L0RA 2TCLA 1I73A 1MMPA 1OO9A 3EDZA 2J0TA 3LUNA 1BQOA 4GF1A 2OVXA 1FLSA 3ZUKA 4I03A 1YCMA 2JSDA 3U1RA 3B2ZA 1HTDA 3DNGA 1L6JA 3LQBA 4GR0A 1AF0A 3DPEA 1QJJA 1JH1A 3GBOA 2CLTA 2WO9A 1RMZA 3LUMA 1C8TA 4WKIA 4R3VA 1PWUA 2MZEA 1JK3A 3USNA 1EB6A 1QJIA 3TSKA 3K7LA 3CKIA 2SRTA 2FV5A 1Z3JA 2OY4A 3BA0A 3MA2A 2ERQA 1GE6A 3KWVC 1PWPA 2YIGA 1ZS0A 3F15A 3EHXA 5LABA 1BQQM 2JT6A 4GQLA 1UTZA 3DPFA 2Y6CA 3E8RA 1ASTA 4H82A 3OHOA 5I3MA 1G9KA 1ATLA 2MLSA 4XM8A 3LK8A 1KUFA 4XM7A 2W12A 1D8FA 1USNA 1Q3AA 4GUYA 4ZR5A 1D5JA 3HDBA 2J83A 4HMAA 1JAQA 1UMTA 3LQ0A 2WO8A 3LE9A 5CZMA 1R1IA 2OY2A 2X3AA 4DF9A 1DTHA 1OM6A 5B5OA 4FXYP 1R54A 4XCTA 2OW2A 3L0VA 1UMSA 4WKEA 1IAGA 1S4BP 3B92A 2V4BA 1CGLA 1HOVA 2OVZA 1JIWP 5D1UA 3G5CA 1IAEA 2O3EA 5D3CA 2DW0A 1GE7A 3DL1A 5D1TA 1FBLA 1YQYA 2YUFA 1JJ9A 1ZVXA 1HY7A 1SMPA 4QKZA 1G05A 3G42A 1JIZA 1KUHA 1YP1A 1D8MA 1GKCA 3DSLA 4Q1LA 1CXVA 4GWNA 1UTTA 1GO8P 1QICA 1R1JA 1IAAA 3F19A 2DW2A 1IACA 2JNPA 4IJOA 3B8ZA 1SLNA 2X3CA 2ERPA 3AYUA 4H76A 1UEAA 2JT5A 1KUKA 2MZHA 5L79A 3EDHA 1XUCA 4EFSA 3HY9A 1CQRA 1QIAA 2K2GA 1IABA 1RM8A 3VTGA 4A7BA 4PKRA 2XS3A 2POJA 1AKLA 4H84A 5I0LA 2OXUA 2OW9A 1KBCA 2FV9A 3KECA 1YOUA 2OXZA 1JANA 3RTSA 1ZXVA 3HBUP 1C7KA 1SRPA 1B3DA 5BOTA 1QIBA 4JP4A 1PWQA 1CIZA 3LGPA 1K7QA 3K7NA 2PJTA 4PKTA 2USNA 4GR8A 3O2XA 3UVCA 3DTEA 1Y0VA 1A86A 1GKDA 1PWVA 3LILA 1XFXA 4H1QA 3F1AA 1BKCA 2EROA 4HX3A 1BSWA 3HDAP 1OS9A 4IUWA 4IN9A 4H3XA 1G49A 3LIKA 3P1VA 2O36A 3ZXHA 4PKWA 3LKAA 4H49A 3TT4A 2WOAA 5I2ZA 1MMRA 1A85A 1O0TA 3EDIA 1G4KA 1CGFA 1D7XA 3EDGA 1OM7A 1J7NA 5D1SA 3DTIA 1ND1A 3HBVP 3LEAA 1SLMA 4L7AA 5CUHA 1BKCE 1CK7A 2HU6A 1Y93A 1KUIA 5B5PA 3LJGA 4GWMA 3HY7A 1G12A 1R55A 1KUGA 3VI1A 4JPAA 3AYKA 4JA1A 3ELMA 3O64A 3I7IA 1MNCA 2Z2DA 1QUAA 5H8XA 3WV2A 2RJPA 2A8HA 4A3WA 1K7GA 4L63A 4AUOA 2Y6DA 3EHYA 4XM6A 1B8YA 5BOYA 2E2DA 3SHIA 3I7GA 2MZIA 3Q2GA 1HFCA 3WV3A 1FM1A 4FU4A 2JIHA 2CKIA 1PWWA 2DDFA 1HFSA 5D7WA 3HYGA 3KMCA 4JIJA 4WK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L6T A;  4PKU A;  3KRY A;  966C A;  2RJQ A;  5I4O A;  1XFW A;  2D1N A;  1R1H A;  2DW1 A;  3N2V A;  1BUD A;  3KEJ A;  4DPE A;  2D1O A;  2K9C A;  1OS2 A;  4H30 A;  3ZVS A;  1SAT A;  1H71 P;  3LJZ A;  4XBH A;  1IAD A;  3HB2 P;  3RTT A;  3AIG A;  1O0Q A;  2N8R A;  2OXW A;  5I43 A;  4GR3 A;  4PKV A;  1SU3 A;  3TVC A;  3OHL A;  3F17 A;  2AYK A;  5CXA A;  1HV5 A;  5L7F A;  1JAP A;  1I1I P;  1C3I A;  1ROS A;  4G0D A;  1XFV A;  5JMY A;  830C A;  4CTH A;  4PKQ A;  3V96 B;  1WNI A;  1GE5 A;  1Y8J A;  4WF6 A;  2YB9 A;  1CAQ A;  4WZV A;  1I76 A;  3WV1 A;  4FXQ A;  1ZTQ A;  2E3X A;  2AIG P;  4PKS A;  1JAO A;  1EAK A;  1BIW A;  456C A;  1AYK A;  4DD8 A;  4AYK A;  3TS4 A;  1BM6 A;  2W13 A;  1BKC I;  4J4M A;  2OW1 A;  5I12 A;  1BZS A;  3LMC A;  1GXD A;  4ILW D;  1EUB A;  4FVL A;  2OZR A;  4AXQ A;  5BPA A;  3EWJ A;  2W15 A;  4H2E A;  1CGE A;  2X3B A;  3LJT A;  3NX7 A;  3DWB A;  2DDY A;  3N2U A;  1JKY A;  1XFU A;  3Q2H A;  1XUD A;  4JQG A;  1BUV M;  3P24 A;  2XS4 A;  1XFY A;  1KAP P;  5D2B A;  2MLR A;  4I35 A;  3F16 A;  3KHI A;  2QPJ A;  3KME A;  4L19 A;  4G9L A;  2OI0 A;  1MMB A;  2OW0 A;  2I47 A;  2W0D A;  3F18 A;  1OM8 A;  1OMJ A;  1K7I A;  1MMQ A;  3KEK A;  1ZP5 A;  1XFZ A;  2X7M A;  3LIR A;  1XUR A;  2KRJ A;  4ON1 A;  3L0T A;  1ZXC A;  1DMT A;  4DV8 A;  1GO7 P;  2W14 A;  4AIG A;  2L0R A;  2TCL A;  1I73 A;  1MMP A;  1OO9 A;  3EDZ A;  2J0T A;  3LUN A;  1BQO A;  4GF1 A;  2OVX A;  1FLS A;  3ZUK A;  4I03 A;  1YCM A;  2JSD A;  3U1R A;  3B2Z A;  1HTD A;  3DNG A;  1L6J A;  3LQB A;  4GR0 A;  1AF0 A;  3DPE A;  1QJJ A;  1JH1 A;  3GBO A;  2CLT A;  2WO9 A;  1RMZ A;  3LUM A;  1C8T A;  4WKI A;  4R3V A;  1PWU A;  2MZE A;  1JK3 A;  3USN A;  1EB6 A;  1QJI A;  3TSK A;  3K7L A;  3CKI A;  2SRT A;  2FV5 A;  1Z3J A;  2OY4 A;  3BA0 A;  3MA2 A;  2ERQ A;  1GE6 A;  3KWV C;  1PWP A;  2YIG A;  1ZS0 A;  3F15 A;  3EHX A;  5LAB A;  1BQQ M;  2JT6 A;  4GQL A;  1UTZ A;  3DPF A;  2Y6C A;  3E8R A;  1AST A;  4H82 A;  3OHO A;  5I3M A;  1G9K A;  1ATL A;  2MLS A;  4XM8 A;  3LK8 A;  1KUF A;  4XM7 A;  2W12 A;  1D8F A;  1USN A;  1Q3A A;  4GUY A;  4ZR5 A;  1D5J A;  3HDB A;  2J83 A;  4HMA A;  1JAQ A;  1UMT A;  3LQ0 A;  2WO8 A;  3LE9 A;  5CZM A;  1R1I A;  2OY2 A;  2X3A A;  4DF9 A;  1DTH A;  1OM6 A;  5B5O A;  4FXY P;  1R54 A;  4XCT A;  2OW2 A;  3L0V A;  1UMS A;  4WKE A;  1IAG A;  1S4B P;  3B92 A;  2V4B A;  1CGL A;  1HOV A;  2OVZ A;  1JIW P;  5D1U A;  3G5C A;  1IAE A;  2O3E A;  5D3C A;  2DW0 A;  1GE7 A;  3DL1 A;  5D1T A;  1FBL A;  1YQY A;  1JJ9 A;  1ZVX A;  1HY7 A;  1SMP A;  4QKZ A;  1G05 A;  3G42 A;  1JIZ A;  1KUH A;  1YP1 A;  1D8M A;  1GKC A;  3DSL A;  4Q1L A;  1CXV A;  4GWN A;  1UTT A;  1GO8 P;  1QIC A;  1R1J A;  1IAA A;  3F19 A;  2DW2 A;  1IAC A;  2JNP A;  4IJO A;  3B8Z A;  1SLN A;  2X3C A;  2ERP A;  3AYU A;  4H76 A;  1UEA A;  2JT5 A;  1KUK A;  2MZH A;  5L79 A;  3EDH A;  1XUC A;  4EFS A;  3HY9 A;  1CQR A;  1QIA A;  2K2G A;  1IAB A;  1RM8 A;  3VTG A;  4A7B A;  4PKR A;  2XS3 A;  2POJ A;  1AKL A;  4H84 A;  5I0L A;  2OXU A;  2OW9 A;  1KBC A;  2FV9 A;  3KEC A;  1YOU A;  2OXZ A;  1JAN A;  3RTS A;  1ZXV A;  3HBU P;  1C7K A;  1SRP A;  1B3D A;  5BOT A;  1QIB A;  4JP4 A;  1PWQ A;  1CIZ A;  3LGP A;  1K7Q A;  3K7N A;  2PJT A;  4PKT A;  2USN A;  4GR8 A;  3O2X A;  3UVC A;  1Y0V A;  1A86 A;  1GKD A;  1PWV A;  3LIL A;  1XFX A;  4H1Q A;  3F1A A;  1BKC A;  2ERO A;  4HX3 A;  1BSW A;  3HDA P;  1OS9 A;  4IUW A;  4IN9 A;  4H3X A;  1G49 A;  3LIK A;  3P1V A;  2O36 A;  3ZXH A;  4PKW A;  3LKA A;  4H49 A;  3TT4 A;  2WOA A;  5I2Z A;  1MMR A;  1A85 A;  1O0T A;  3EDI A;  1G4K A;  1CGF A;  1D7X A;  3EDG A;  1OM7 A;  1J7N A;  5D1S A;  1ND1 A;  3HBV P;  3LEA A;  1SLM A;  5CUH A;  1BKC E;  1CK7 A;  2HU6 A;  1Y93 A;  1KUI A;  5B5P A;  3LJG A;  4GWM A;  3HY7 A;  1G12 A;  1R55 A;  1KUG A;  3VI1 A;  4JPA A;  3AYK A;  4JA1 A;  3ELM A;  3O64 A;  3I7I A;  1MNC A;  2Z2D A;  1QUA A;  5H8X A;  3WV2 A;  2RJP A;  2A8H A;  4A3W A;  1K7G A;  4L63 A;  4AUO A;  2Y6D A;  3EHY A;  4XM6 A;  1B8Y A;  5BOY A;  2E2D A;  3SHI A;  3I7G A;  2MZI A;  3Q2G A;  1HFC A;  3WV3 A;  1FM1 A;  4FU4 A;  2JIH A;  2CKI A;  1PWW A;  2DDF A;  1HFS A;  5D7W A;  3HYG A;  3KMC A;  4JIJ A;  4WK7 A; 
#chains in the Genus database with same CATH topology
 4L6T A;  4PKU A;  3KRY A;  966C A;  2RJQ A;  5I4O A;  1XFW A;  2D1N A;  1R1H A;  2DW1 A;  3N2V A;  1BUD A;  3KEJ A;  4DPE A;  2D1O A;  2K9C A;  1OS2 A;  4H30 A;  3ZVS A;  1SAT A;  1H71 P;  3LJZ A;  4XBH A;  1IAD A;  3HB2 P;  3RTT A;  3AIG A;  1O0Q A;  2N8R A;  2OXW A;  5I43 A;  4GR3 A;  4PKV A;  1SU3 A;  3TVC A;  3OHL A;  3F17 A;  2AYK A;  5CXA A;  1HV5 A;  5L7F A;  1JAP A;  1I1I P;  1C3I A;  1ROS A;  4G0D A;  1XFV A;  5JMY A;  830C A;  4CTH A;  4PKQ A;  3V96 B;  1WNI A;  1GE5 A;  1Y8J A;  4WF6 A;  2YB9 A;  1CAQ A;  4WZV A;  1I76 A;  3WV1 A;  4FXQ A;  1ZTQ A;  2E3X A;  2AIG P;  4PKS A;  1JAO A;  1EAK A;  1BIW A;  456C A;  1AYK A;  4DD8 A;  4AYK A;  3TS4 A;  1BM6 A;  2W13 A;  1BKC I;  4J4M A;  2OW1 A;  5I12 A;  1BZS A;  3LMC A;  1GXD A;  4ILW D;  1EUB A;  3DTK A;  4FVL A;  2OZR A;  4AXQ A;  5BPA A;  3EWJ A;  2W15 A;  4H2E A;  1CGE A;  2X3B A;  3LJT A;  1XAX A;  3DWB A;  2DDY A;  3N2U A;  1JKY A;  3NX7 A;  1XFU A;  3Q2H A;  1XUD A;  4JQG A;  1BUV M;  3P24 A;  2XS4 A;  1XFY A;  1KAP P;  5D2B A;  2MLR A;  4I35 A;  3F16 A;  3KHI A;  2QPJ A;  3KME A;  4L19 A;  4G9L A;  2OI0 A;  1MMB A;  2OW0 A;  2I47 A;  2W0D A;  3F18 A;  1OM8 A;  1OMJ A;  1K7I A;  1MMQ A;  3KEK A;  1ZP5 A;  1XFZ A;  2X7M A;  3LIR A;  1XUR A;  2KRJ A;  4ON1 A;  3L0T A;  1ZXC A;  1DMT A;  4DV8 A;  1GO7 P;  2W14 A;  4AIG A;  2L0R A;  2TCL A;  1I73 A;  1MMP A;  1OO9 A;  3EDZ A;  2J0T A;  3LUN A;  1BQO A;  4GF1 A;  2OVX A;  1FLS A;  3ZUK A;  4I03 A;  1YCM A;  2JSD A;  3U1R A;  3B2Z A;  1HTD A;  3DNG A;  1L6J A;  3LQB A;  4GR0 A;  1AF0 A;  3DPE A;  1QJJ A;  1JH1 A;  3GBO A;  2CLT A;  2WO9 A;  1RMZ A;  3LUM A;  1C8T A;  4WKI A;  4R3V A;  1PWU A;  2MZE A;  1JK3 A;  3USN A;  1EB6 A;  1QJI A;  3TSK A;  3K7L A;  3CKI A;  2SRT A;  2FV5 A;  1Z3J A;  2OY4 A;  3BA0 A;  3MA2 A;  2ERQ A;  1GE6 A;  3KWV C;  1PWP A;  2YIG A;  1ZS0 A;  3F15 A;  3EHX A;  5LAB A;  1BQQ M;  2JT6 A;  4GQL A;  1UTZ A;  3DPF A;  2Y6C A;  3E8R A;  1AST A;  4H82 A;  3OHO A;  5I3M A;  1G9K A;  1ATL A;  2MLS A;  4XM8 A;  3LK8 A;  1KUF A;  4XM7 A;  2W12 A;  1D8F A;  1USN A;  1Q3A A;  4GUY A;  4ZR5 A;  1D5J A;  3HDB A;  2J83 A;  4HMA A;  1JAQ A;  1UMT A;  3LQ0 A;  2WO8 A;  3LE9 A;  5CZM A;  1R1I A;  2OY2 A;  2X3A A;  4DF9 A;  1DTH A;  1OM6 A;  5B5O A;  4FXY P;  1R54 A;  4XCT A;  2OW2 A;  3L0V A;  1UMS A;  4WKE A;  1IAG A;  1S4B P;  3B92 A;  2V4B A;  1CGL A;  1HOV A;  2OVZ A;  1JIW P;  5D1U A;  3G5C A;  1IAE A;  2O3E A;  5D3C A;  2DW0 A;  1GE7 A;  3DL1 A;  5D1T A;  1FBL A;  1YQY A;  2YUF A;  1JJ9 A;  1ZVX A;  1HY7 A;  1SMP A;  4QKZ A;  1G05 A;  3G42 A;  1JIZ A;  1KUH A;  1YP1 A;  1D8M A;  1GKC A;  3DSL A;  4Q1L A;  1CXV A;  4GWN A;  1UTT A;  1GO8 P;  1QIC A;  1R1J A;  1IAA A;  3F19 A;  2DW2 A;  1IAC A;  2JNP A;  4IJO A;  3B8Z A;  1SLN A;  2X3C A;  2ERP A;  3AYU A;  4H76 A;  1UEA A;  2JT5 A;  1KUK A;  2MZH A;  5L79 A;  3EDH A;  1XUC A;  4EFS A;  3HY9 A;  1CQR A;  1QIA A;  2K2G A;  1IAB A;  1RM8 A;  3VTG A;  1XM5 A;  4A7B A;  4PKR A;  2XS3 A;  2POJ A;  1AKL A;  4H84 A;  5I0L A;  2OXU A;  1TVI A;  2OW9 A;  1KBC A;  2FV9 A;  3KEC A;  1YOU A;  2OXZ A;  1JAN A;  3RTS A;  1ZXV A;  3HBU P;  1C7K A;  1SRP A;  1B3D A;  5BOT A;  1QIB A;  4JP4 A;  1PWQ A;  1CIZ A;  3LGP A;  1K7Q A;  3K7N A;  2PJT A;  4PKT A;  2USN A;  4GR8 A;  3O2X A;  3UVC A;  3DTE A;  1Y0V A;  1A86 A;  1GKD A;  1PWV A;  3LIL A;  1XFX A;  4H1Q A;  3F1A A;  1BKC A;  2ERO A;  4HX3 A;  1BSW A;  3HDA P;  1OS9 A;  4IUW A;  4IN9 A;  4H3X A;  1G49 A;  3LIK A;  3P1V A;  2O36 A;  3ZXH A;  4PKW A;  3LKA A;  4H49 A;  3TT4 A;  2WOA A;  5I2Z A;  1MMR A;  1A85 A;  1O0T A;  3EDI A;  1G4K A;  1CGF A;  1D7X A;  3EDG A;  1OM7 A;  1J7N A;  5D1S A;  3DTI A;  1OZ9 A;  1ND1 A;  3HBV P;  3LEA A;  1SLM A;  4L7A A;  5CUH A;  1BKC E;  1CK7 A;  2HU6 A;  1Y93 A;  1KUI A;  5B5P A;  3LJG A;  4GWM A;  3HY7 A;  1G12 A;  1R55 A;  1KUG A;  3VI1 A;  4JPA A;  3AYK A;  4JA1 A;  3ELM A;  3O64 A;  3I7I A;  1MNC A;  2Z2D A;  1QUA A;  5H8X A;  3WV2 A;  2RJP A;  2A8H A;  4A3W A;  1K7G A;  4L63 A;  4AUO A;  2Y6D A;  3EHY A;  4XM6 A;  1B8Y A;  5BOY A;  2E2D A;  3SHI A;  3I7G A;  2MZI A;  3Q2G A;  1HFC A;  3WV3 A;  1FM1 A;  4FU4 A;  2JIH A;  2CKI A;  1PWW A;  2DDF A;  1HFS A;  5D7W A;  3HYG A;  3KMC A;  4JIJ A;  4WK7 A; 
#chains in the Genus database with same CATH homology
 4L6T A;  4PKU A;  3KRY A;  966C A;  2RJQ A;  5I4O A;  1XFW A;  2D1N A;  1R1H A;  2DW1 A;  3N2V A;  1BUD A;  3KEJ A;  4DPE A;  2D1O A;  2K9C A;  1OS2 A;  4H30 A;  3ZVS A;  1SAT A;  1H71 P;  3LJZ A;  4XBH A;  1IAD A;  3HB2 P;  3RTT A;  3AIG A;  1O0Q A;  2N8R A;  2OXW A;  5I43 A;  4GR3 A;  4PKV A;  1SU3 A;  3TVC A;  3OHL A;  3F17 A;  2AYK A;  5CXA A;  1HV5 A;  5L7F A;  1JAP A;  1I1I P;  1C3I A;  1ROS A;  4G0D A;  1XFV A;  5JMY A;  830C A;  4CTH A;  4PKQ A;  3V96 B;  1WNI A;  1GE5 A;  1Y8J A;  4WF6 A;  2YB9 A;  1CAQ A;  4WZV A;  1I76 A;  3WV1 A;  4FXQ A;  1ZTQ A;  2E3X A;  2AIG P;  4PKS A;  1JAO A;  1EAK A;  1BIW A;  456C A;  1AYK A;  4DD8 A;  4AYK A;  3TS4 A;  1BM6 A;  2W13 A;  1BKC I;  4J4M A;  2OW1 A;  5I12 A;  1BZS A;  3LMC A;  1GXD A;  4ILW D;  1EUB A;  3DTK A;  4FVL A;  2OZR A;  4AXQ A;  5BPA A;  3EWJ A;  2W15 A;  4H2E A;  1CGE A;  2X3B A;  3LJT A;  3NX7 A;  3DWB A;  2DDY A;  3N2U A;  1JKY A;  1XFU A;  3Q2H A;  1XUD A;  4JQG A;  1BUV M;  3P24 A;  2XS4 A;  1XFY A;  1KAP P;  5D2B A;  2MLR A;  4I35 A;  3F16 A;  3KHI A;  2QPJ A;  3KME A;  4L19 A;  4G9L A;  2OI0 A;  1MMB A;  2OW0 A;  2I47 A;  2W0D A;  3F18 A;  1OM8 A;  1OMJ A;  1K7I A;  1MMQ A;  3KEK A;  1ZP5 A;  1XFZ A;  2X7M A;  3LIR A;  1XUR A;  2KRJ A;  4ON1 A;  3L0T A;  1ZXC A;  1DMT A;  4DV8 A;  1GO7 P;  2W14 A;  4AIG A;  2L0R A;  2TCL A;  1I73 A;  1MMP A;  1OO9 A;  3EDZ A;  2J0T A;  3LUN A;  1BQO A;  4GF1 A;  2OVX A;  1FLS A;  3ZUK A;  4I03 A;  1YCM A;  2JSD A;  3U1R A;  3B2Z A;  1HTD A;  3DNG A;  1L6J A;  3LQB A;  4GR0 A;  1AF0 A;  3DPE A;  1QJJ A;  1JH1 A;  3GBO A;  2CLT A;  2WO9 A;  1RMZ A;  3LUM A;  1C8T A;  4WKI A;  4R3V A;  1PWU A;  2MZE A;  1JK3 A;  3USN A;  1EB6 A;  1QJI A;  3TSK A;  3K7L A;  3CKI A;  2SRT A;  2FV5 A;  1Z3J A;  2OY4 A;  3BA0 A;  3MA2 A;  2ERQ A;  1GE6 A;  3KWV C;  1PWP A;  2YIG A;  1ZS0 A;  3F15 A;  3EHX A;  5LAB A;  1BQQ M;  2JT6 A;  4GQL A;  1UTZ A;  3DPF A;  2Y6C A;  3E8R A;  1AST A;  4H82 A;  3OHO A;  5I3M A;  1G9K A;  1ATL A;  2MLS A;  4XM8 A;  3LK8 A;  1KUF A;  4XM7 A;  2W12 A;  1D8F A;  1USN A;  1Q3A A;  4GUY A;  4ZR5 A;  1D5J A;  3HDB A;  2J83 A;  4HMA A;  1JAQ A;  1UMT A;  3LQ0 A;  2WO8 A;  3LE9 A;  5CZM A;  1R1I A;  2OY2 A;  2X3A A;  4DF9 A;  1DTH A;  1OM6 A;  5B5O A;  4FXY P;  1R54 A;  4XCT A;  2OW2 A;  3L0V A;  1UMS A;  4WKE A;  1IAG A;  1S4B P;  3B92 A;  2V4B A;  1CGL A;  1HOV A;  2OVZ A;  1JIW P;  5D1U A;  3G5C A;  1IAE A;  2O3E A;  5D3C A;  2DW0 A;  1GE7 A;  3DL1 A;  5D1T A;  1FBL A;  1YQY A;  2YUF A;  1JJ9 A;  1ZVX A;  1HY7 A;  1SMP A;  4QKZ A;  1G05 A;  3G42 A;  1JIZ A;  1KUH A;  1YP1 A;  1D8M A;  1GKC A;  3DSL A;  4Q1L A;  1CXV A;  4GWN A;  1UTT A;  1GO8 P;  1QIC A;  1R1J A;  1IAA A;  3F19 A;  2DW2 A;  1IAC A;  2JNP A;  4IJO A;  3B8Z A;  1SLN A;  2X3C A;  2ERP A;  3AYU A;  4H76 A;  1UEA A;  2JT5 A;  1KUK A;  2MZH A;  5L79 A;  3EDH A;  1XUC A;  4EFS A;  3HY9 A;  1CQR A;  1QIA A;  2K2G A;  1IAB A;  1RM8 A;  3VTG A;  4A7B A;  4PKR A;  2XS3 A;  2POJ A;  1AKL A;  4H84 A;  5I0L A;  2OXU A;  2OW9 A;  1KBC A;  2FV9 A;  3KEC A;  1YOU A;  2OXZ A;  1JAN A;  3RTS A;  1ZXV A;  3HBU P;  1C7K A;  1SRP A;  1B3D A;  5BOT A;  1QIB A;  4JP4 A;  1PWQ A;  1CIZ A;  3LGP A;  1K7Q A;  3K7N A;  2PJT A;  4PKT A;  2USN A;  4GR8 A;  3O2X A;  3UVC A;  3DTE A;  1Y0V A;  1A86 A;  1GKD A;  1PWV A;  3LIL A;  1XFX A;  4H1Q A;  3F1A A;  1BKC A;  2ERO A;  4HX3 A;  1BSW A;  3HDA P;  1OS9 A;  4IUW A;  4IN9 A;  4H3X A;  1G49 A;  3LIK A;  3P1V A;  2O36 A;  3ZXH A;  4PKW A;  3LKA A;  4H49 A;  3TT4 A;  2WOA A;  5I2Z A;  1MMR A;  1A85 A;  1O0T A;  3EDI A;  1G4K A;  1CGF A;  1D7X A;  3EDG A;  1OM7 A;  1J7N A;  5D1S A;  3DTI A;  1ND1 A;  3HBV P;  3LEA A;  1SLM A;  4L7A A;  5CUH A;  1BKC E;  1CK7 A;  2HU6 A;  1Y93 A;  1KUI A;  5B5P A;  3LJG A;  4GWM A;  3HY7 A;  1G12 A;  1R55 A;  1KUG A;  3VI1 A;  4JPA A;  3AYK A;  4JA1 A;  3ELM A;  3O64 A;  3I7I A;  1MNC A;  2Z2D A;  1QUA A;  5H8X A;  3WV2 A;  2RJP A;  2A8H A;  4A3W A;  1K7G A;  4L63 A;  4AUO A;  2Y6D A;  3EHY A;  4XM6 A;  1B8Y A;  5BOY A;  2E2D A;  3SHI A;  3I7G A;  2MZI A;  3Q2G A;  1HFC A;  3WV3 A;  1FM1 A;  4FU4 A;  2JIH A;  2CKI A;  1PWW A;  2DDF A;  1HFS A;  5D7W A;  3HYG A;  3KMC A;  4JIJ A;  4WK7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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