5I4OA

Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated triazole-linked carboxylate zinc-chelator water-soluble inhibitor (dc28).
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
156
structure length
156
Chain Sequence
VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 50
structure length 156
sequence length 156
chains with identical sequence B, C, D
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2016-02-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 5i4oA00
4R3VA 2W14A 1FM1A 1A86A 1R54A 1SLNA 966CA 1JAOA 2AIGP 1KUGA 3KHIA 1OS9A 4XM8A 1Z3JA 3OHOA 1D8FA 1BQOA 456CA 2OXZA 1OMJA 1G49A 1HFCA 2OY2A 3DWBA 1ZP5A 1GO7P 1HV5A 3G5CA 4XBHA 1I76A 2E3XA 3GBOA 4GUYA 3EHYA 3LQ0A 2CLTA 3OHLA 1H71P 4L6TA 3ZUKA 4G9LA 1CIZA 1Y93A 3AYUA 4QKZA 3EWJA 1OM6A 1FLSA 3LKAA 5CXAA 3KEJA 1PWUA 1XUDA 3Q2GA 3LUNA 1OO9A 4HX3A 2OW1A 1FBLA 1C3IA 1GXDA 3DL1A 1G4KA 1EUBA 4JPAA 3F15A 2PJTA 1ASTA 1ZS0A 2FV9A 2O3EA 4HMAA 1KUIA 2AYKA 3USNA 2QPJA 1ZTQA 1XFZA 1D7XA 4FXYP 4IN9A 1IAGA 1ZXCA 5I12A 4IJOA 5D1SA 2K9CA 1BQQM 1UTZA 5I43A 5L79A 3RTSA 4AXQA 1MNCA 1JAQA 1PWQA 3TT4A 3TVCA 2WOAA 4GR3A 2Z2DA 1D8MA 3LEAA 3F19A 1IACA 4GWMA 2O36A 3G42A 4PKVA 2JIHA 1ATLA 1JIWP 3KMCA 1BZSA 3HYGA 4A3WA 1OS2A 2OXUA 1O0QA 3TS4A 1YP1A 1R1JA 1GE5A 2JT5A 1GKDA 1SATA 5CZMA 3F16A 2Y6CA 1KUHA 4AIGA 4PKQA 1MMBA 1B8YA 5JMYA 1I73A 5B5OA 4J4MA 2N8RA 1GKCA 2YIGA 1AYKA 5BOYA 2OY4A 1K7GA 2K2GA 4H82A 2X7MA 4FU4A 2DW1A 2MLSA 1QJJA 1HOVA 1QUAA 1JAPA 2DDYA 2RJQA 3EHXA 1IAEA 5H8XA 3VI1A 4JQGA 3DPFA 1JIZA 4PKWA 1USNA 1BSWA 3ELMA 2DW0A 4WKIA 2V4BA 3U1RA 3EDGA 3HDAP 2DDFA 1SU3A 1XUCA 3LMCA 3P24A 4XM7A 1UEAA 4H2EA 1IADA 3B2ZA 1YQYA 1ZXVA 4IUWA 3WV2A 1B3DA 5D1UA 1Q3AA 1BKCA 3BA0A 3CKIA 4GR0A 1R1IA 1PWWA 1JK3A 2A8HA 1G9KA 1G12A 2JNPA 2MZHA 4CTHA 1KUKA 1BUVM 2JT6A 2POJA 1SLMA 1UMSA 1QICA 2W15A 4GQLA 1Y8JA 2D1NA 3LIRA 2Y6DA 3DNGA 3K7NA 3LQBA 1CQRA 830CA 4PKSA 4JA1A 2CKIA 3B8ZA 4L19A 4ON1A 3I7GA 4GF1A 2J83A 1R1HA 1GO8P 4JP4A 3HBUP 4FXQA 3N2VA 4GR8A 3DSLA 2W0DA 2OVXA 3HY7A 4H3XA 2SRTA 3K7LA 1MMPA 4PKUA 1Y0VA 4G0DA 2E2DA 4PKRA 1S4BP 1XFXA 2YB9A 2W13A 4I35A 5BOTA 1XFYA 1JKYA 2OVZA 3I7IA 4WKEA 1BIWA 4Q1LA 1ROSA 3B92A 4XCTA 3L0VA 3KMEA 3MA2A 3N2UA 4WF6A 5D2BA 1CAQA 5I0LA 1C7KA 1JJ9A 3EDIA 4WK7A 1GE6A 3LE9A 3RTTA 3EDZA 1GE7A 1XFUA 2KRJA 2I47A 3HY9A 1IABA 5I4OA 5LABA 2L0RA 1XFVA 2ERPA 3Q2HA 1EAKA 2HU6A 4DV8A 2OW0A 1CGLA 1D5JA 1JH1A 1L6JA 1BKCE 1EB6A 2USNA 3LK8A 3HDBA 1UTTA 1RMZA 1O0TA 1OM7A 2EROA 2WO8A 4ZR5A 3AIGA 1RM8A 1XFWA 2WO9A 5CUHA 1J7NA 3VTGA 1A85A 1HFSA 4H49A 1BKCI 3SHIA 1AF0A 1BM6A 1SMPA 2J0TA 1C8TA 3AYKA 2X3BA 5I2ZA 1XURA 1MMQA 3ZXHA 1JANA 3NX7A 4ILWD 3WV3A 1QIBA 1ZVXA 4H76A 4XM6A 3DPEA 4H30A 2TCLA 4FVLA 1QIAA 3ZVSA 4AYKA 3TSKA 3LJZA 3HB2P 1UMTA 3HBVP 1G05A 1IAAA 2MLRA 4WZVA 1BUDA 4DD8A 2X3CA 2JSDA 1CXVA 1CGEA 1I1IP 2OI0A 3KRYA 5B5PA 3V96B 3LGPA 1KUFA 1WNIA 3L0TA 5D3CA 5D7WA 1YOUA 3O64A 4GWNA 2OZRA 4DF9A 4AUOA 4PKTA 3E8RA 3KWVC 3F18A 2X3AA 2OW2A 3F1AA 2DW2A 4L63A 2RJPA 4H1QA 3P1VA 1DTHA 3LJTA 1ND1A 2D1OA 4EFSA 2MZIA 1DMTA 4H84A 1AKLA 2ERQA 1K7QA 4A7BA 1SRPA 2FV5A 5BPAA 1QJIA 2XS3A 1PWVA 3KECA 1K7IA 1KBCA 2OW9A 1HY7A 2MZEA 3LIKA 3LUMA 1HTDA 2W12A 4DPEA 3LJGA 2XS4A 3F17A 5L7FA 1R55A 1MMRA 1CGFA 1KAPP 4I03A 3LILA 1OM8A 3EDHA 2OXWA 4JIJA 3KEKA 1YCMA 1PWPA 3UVCA 1CK7A 3WV1A 5D1TA 3O2XA 5I3MA
chains in the Genus database with same CATH superfamily
4R3VA 2W14A 1FM1A 1A86A 1R54A 1SLNA 966CA 1JAOA 2AIGP 1KUGA 3KHIA 1OS9A 4XM8A 1Z3JA 3OHOA 1D8FA 1BQOA 456CA 2OXZA 1OMJA 1G49A 1HFCA 2OY2A 3DWBA 1ZP5A 1GO7P 1HV5A 3G5CA 4XBHA 1I76A 2E3XA 3GBOA 4GUYA 3EHYA 3LQ0A 2CLTA 3OHLA 3DTEA 1H71P 4L6TA 3ZUKA 4G9LA 1CIZA 1Y93A 3AYUA 4QKZA 3EWJA 1OM6A 1FLSA 3LKAA 5CXAA 3KEJA 1PWUA 1XUDA 3Q2GA 4L7AA 3LUNA 1OO9A 4HX3A 2OW1A 1FBLA 1C3IA 1GXDA 3DL1A 1G4KA 1EUBA 4JPAA 3F15A 2PJTA 1ASTA 1ZS0A 2FV9A 2O3EA 4HMAA 1KUIA 2AYKA 3USNA 2QPJA 1ZTQA 1XFZA 1D7XA 4FXYP 4IN9A 1IAGA 1ZXCA 5I12A 4IJOA 5D1SA 2K9CA 1BQQM 1UTZA 5I43A 5L79A 3RTSA 4AXQA 1MNCA 1JAQA 1PWQA 3TT4A 3TVCA 2WOAA 4GR3A 2Z2DA 1D8MA 3LEAA 3F19A 1IACA 4GWMA 2O36A 3G42A 4PKVA 2JIHA 1ATLA 1JIWP 3KMCA 1BZSA 3HYGA 4A3WA 1OS2A 2OXUA 1O0QA 3TS4A 1YP1A 1R1JA 1GE5A 2JT5A 1GKDA 1SATA 1OZ9A 5CZMA 3F16A 2Y6CA 1KUHA 4AIGA 4PKQA 1MMBA 1B8YA 5JMYA 1I73A 5B5OA 4J4MA 2N8RA 1GKCA 2YIGA 1AYKA 5BOYA 2OY4A 1K7GA 2K2GA 4H82A 2X7MA 4FU4A 2DW1A 2MLSA 1QJJA 1HOVA 1QUAA 1JAPA 2DDYA 2RJQA 3EHXA 1IAEA 5H8XA 3VI1A 4JQGA 3DPFA 1JIZA 4PKWA 1USNA 1BSWA 3ELMA 2DW0A 4WKIA 2V4BA 3U1RA 3EDGA 3HDAP 2DDFA 1SU3A 1XUCA 3LMCA 3P24A 4XM7A 1UEAA 4H2EA 1IADA 3B2ZA 1YQYA 1ZXVA 4IUWA 3WV2A 1B3DA 5D1UA 1Q3AA 1BKCA 3BA0A 3CKIA 4GR0A 1R1IA 1PWWA 2YUFA 1JK3A 2A8HA 1G9KA 1G12A 2JNPA 3DTKA 2MZHA 4CTHA 1KUKA 1BUVM 2JT6A 2POJA 1SLMA 1UMSA 1QICA 2W15A 4GQLA 1Y8JA 1XM5A 2D1NA 2Y6DA 3LIRA 3DNGA 3K7NA 3LQBA 1CQRA 830CA 4PKSA 4JA1A 2CKIA 3B8ZA 4L19A 4ON1A 3I7GA 4GF1A 2J83A 1R1HA 1GO8P 4JP4A 3HBUP 4FXQA 3N2VA 4GR8A 3DSLA 2W0DA 2OVXA 3HY7A 4H3XA 2SRTA 3K7LA 1MMPA 4PKUA 1Y0VA 4G0DA 2E2DA 4PKRA 1S4BP 1XFXA 2YB9A 2W13A 4I35A 5BOTA 1XFYA 1JKYA 2OVZA 3I7IA 4WKEA 1BIWA 4Q1LA 1ROSA 3B92A 4XCTA 3L0VA 3KMEA 3MA2A 3N2UA 4WF6A 5D2BA 1CAQA 5I0LA 1C7KA 1JJ9A 3EDIA 4WK7A 1GE6A 3LE9A 3RTTA 3EDZA 1GE7A 1XFUA 2KRJA 2I47A 3HY9A 1IABA 5I4OA 5LABA 2L0RA 1XFVA 2ERPA 3Q2HA 1EAKA 2HU6A 4DV8A 2OW0A 1CGLA 1D5JA 1JH1A 1L6JA 1BKCE 1EB6A 2USNA 3LK8A 3HDBA 1UTTA 1RMZA 1O0TA 1OM7A 2EROA 2WO8A 4ZR5A 3AIGA 1RM8A 1XFWA 1XAXA 2WO9A 5CUHA 1J7NA 3VTGA 1A85A 1HFSA 4H49A 1BKCI 3SHIA 1AF0A 1BM6A 1SMPA 2J0TA 1C8TA 3AYKA 2X3BA 5I2ZA 1XURA 1MMQA 3ZXHA 1JANA 3NX7A 4ILWD 3WV3A 1QIBA 1ZVXA 4H76A 4XM6A 3DPEA 4H30A 2TCLA 4FVLA 1QIAA 3ZVSA 4AYKA 3TSKA 3LJZA 3HB2P 1UMTA 3HBVP 1G05A 1IAAA 2MLRA 4WZVA 1BUDA 4DD8A 2X3CA 2JSDA 1CXVA 1CGEA 1I1IP 2OI0A 3DTIA 3KRYA 5B5PA 3V96B 3LGPA 1KUFA 1WNIA 3L0TA 5D3CA 5D7WA 1YOUA 3O64A 4GWNA 2OZRA 4DF9A 4AUOA 4PKTA 3E8RA 3KWVC 3F18A 2X3AA 2OW2A 3F1AA 2DW2A 4L63A 2RJPA 4H1QA 3P1VA 1DTHA 3LJTA 1ND1A 2D1OA 4EFSA 2MZIA 1DMTA 4H84A 1AKLA 2ERQA 1K7QA 4A7BA 1SRPA 2FV5A 5BPAA 1QJIA 2XS3A 1PWVA 3KECA 1K7IA 1KBCA 2OW9A 1HY7A 2MZEA 3LIKA 3LUMA 1HTDA 2W12A 4DPEA 3LJGA 2XS4A 3F17A 5L7FA 1R55A 1MMRA 1CGFA 1TVIA 1KAPP 4I03A 3LILA 1OM8A 3EDHA 2OXWA 4JIJA 3KEKA 1YCMA 1PWPA 3UVCA 1CK7A 3WV1A 5D1TA 3O2XA 5I3MA
chains in the Genus database with same CATH topology
4R3VA 2W14A 1FM1A 1A86A 1R54A 1SLNA 966CA 1JAOA 2AIGP 1KUGA 3KHIA 1OS9A 4XM8A 1Z3JA 3OHOA 1D8FA 1BQOA 456CA 2OXZA 1OMJA 1G49A 1HFCA 2OY2A 3DWBA 1ZP5A 1GO7P 1HV5A 3G5CA 4XBHA 1I76A 2E3XA 3GBOA 4GUYA 3EHYA 3LQ0A 2CLTA 3OHLA 3DTEA 1H71P 4L6TA 3ZUKA 4G9LA 1CIZA 1Y93A 3AYUA 4QKZA 3EWJA 1OM6A 1FLSA 3LKAA 5CXAA 3KEJA 1PWUA 1XUDA 3Q2GA 4L7AA 3LUNA 1OO9A 4HX3A 2OW1A 1FBLA 1C3IA 1GXDA 3DL1A 1G4KA 1EUBA 4JPAA 3F15A 2PJTA 1ASTA 1ZS0A 2FV9A 2O3EA 4HMAA 1KUIA 2AYKA 3USNA 2QPJA 1ZTQA 1XFZA 1D7XA 4FXYP 4IN9A 1IAGA 1ZXCA 5I12A 4IJOA 5D1SA 2K9CA 1BQQM 1UTZA 5I43A 5L79A 3RTSA 4AXQA 1MNCA 1JAQA 1PWQA 3TT4A 3TVCA 2WOAA 4GR3A 2Z2DA 1D8MA 3LEAA 3F19A 1IACA 4GWMA 2O36A 3G42A 4PKVA 2JIHA 1ATLA 1JIWP 3KMCA 1BZSA 3HYGA 4A3WA 1OS2A 2OXUA 1O0QA 3TS4A 1YP1A 1R1JA 1GE5A 2JT5A 1GKDA 1SATA 5CZMA 3F16A 2Y6CA 1KUHA 4AIGA 4PKQA 1MMBA 1B8YA 5JMYA 1I73A 5B5OA 4J4MA 2N8RA 1GKCA 2YIGA 1AYKA 5BOYA 2OY4A 1K7GA 2K2GA 4H82A 2X7MA 4FU4A 2DW1A 2MLSA 1QJJA 1HOVA 1QUAA 1JAPA 2DDYA 2RJQA 3EHXA 1IAEA 5H8XA 3VI1A 4JQGA 3DPFA 1JIZA 4PKWA 1USNA 1BSWA 3ELMA 2DW0A 4WKIA 2V4BA 3U1RA 3EDGA 3HDAP 2DDFA 1SU3A 1XUCA 3LMCA 3P24A 4XM7A 1UEAA 4H2EA 1IADA 3B2ZA 1YQYA 1ZXVA 4IUWA 3WV2A 1B3DA 5D1UA 1Q3AA 1BKCA 3BA0A 3CKIA 4GR0A 1R1IA 1PWWA 2YUFA 1JK3A 2A8HA 1G9KA 1G12A 2JNPA 3DTKA 2MZHA 4CTHA 1KUKA 1BUVM 2JT6A 2POJA 1SLMA 1UMSA 1QICA 2W15A 4GQLA 1Y8JA 2D1NA 3LIRA 2Y6DA 3DNGA 3K7NA 3LQBA 1CQRA 830CA 4PKSA 4JA1A 2CKIA 3B8ZA 4L19A 4ON1A 3I7GA 4GF1A 2J83A 1R1HA 1GO8P 4JP4A 3HBUP 4FXQA 3N2VA 4GR8A 3DSLA 2W0DA 2OVXA 3HY7A 4H3XA 2SRTA 3K7LA 1MMPA 4PKUA 1Y0VA 4G0DA 2E2DA 4PKRA 1S4BP 1XFXA 2YB9A 2W13A 4I35A 5BOTA 1XFYA 1JKYA 2OVZA 3I7IA 4WKEA 1BIWA 4Q1LA 1ROSA 3B92A 4XCTA 3L0VA 3KMEA 3MA2A 3N2UA 4WF6A 5D2BA 1CAQA 5I0LA 1C7KA 1JJ9A 3EDIA 4WK7A 1GE6A 3LE9A 3RTTA 3EDZA 1GE7A 1XFUA 2KRJA 2I47A 3HY9A 1IABA 5I4OA 5LABA 2L0RA 1XFVA 2ERPA 3Q2HA 1EAKA 2HU6A 4DV8A 2OW0A 1CGLA 1D5JA 1JH1A 1L6JA 1BKCE 1EB6A 2USNA 3LK8A 3HDBA 1UTTA 1RMZA 1O0TA 1OM7A 2EROA 2WO8A 4ZR5A 3AIGA 1RM8A 1XFWA 2WO9A 5CUHA 1J7NA 3VTGA 1A85A 1HFSA 4H49A 1BKCI 3SHIA 1AF0A 1BM6A 1SMPA 2J0TA 1C8TA 3AYKA 2X3BA 5I2ZA 1XURA 1MMQA 3ZXHA 1JANA 3NX7A 4ILWD 3WV3A 1QIBA 1ZVXA 4H76A 4XM6A 3DPEA 4H30A 2TCLA 4FVLA 1QIAA 3ZVSA 4AYKA 3TSKA 3LJZA 3HB2P 1UMTA 3HBVP 1G05A 1IAAA 2MLRA 4WZVA 1BUDA 4DD8A 2X3CA 2JSDA 1CXVA 1CGEA 1I1IP 2OI0A 3DTIA 3KRYA 5B5PA 3V96B 3LGPA 1KUFA 1WNIA 3L0TA 5D3CA 5D7WA 1YOUA 3O64A 4GWNA 2OZRA 4DF9A 4AUOA 4PKTA 3E8RA 3KWVC 3F18A 2X3AA 2OW2A 3F1AA 2DW2A 4L63A 2RJPA 4H1QA 3P1VA 1DTHA 3LJTA 1ND1A 2D1OA 4EFSA 2MZIA 1DMTA 4H84A 1AKLA 2ERQA 1K7QA 4A7BA 1SRPA 2FV5A 5BPAA 1QJIA 2XS3A 1PWVA 3KECA 1K7IA 1KBCA 2OW9A 1HY7A 2MZEA 3LIKA 3LUMA 1HTDA 2W12A 4DPEA 3LJGA 2XS4A 3F17A 5L7FA 1R55A 1MMRA 1CGFA 1KAPP 4I03A 3LILA 1OM8A 3EDHA 2OXWA 4JIJA 3KEKA 1YCMA 1PWPA 3UVCA 1CK7A 3WV1A 5D1TA 3O2XA 5I3MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4R3V A;  2W14 A;  1FM1 A;  1A86 A;  1R54 A;  1SLN A;  966C A;  1JAO A;  2AIG P;  1KUG A;  3KHI A;  1OS9 A;  4XM8 A;  1Z3J A;  3OHO A;  1D8F A;  1BQO A;  456C A;  2OXZ A;  1OMJ A;  1G49 A;  1HFC A;  2OY2 A;  3DWB A;  1ZP5 A;  1GO7 P;  1HV5 A;  3G5C A;  4XBH A;  1I76 A;  2E3X A;  3GBO A;  4GUY A;  3EHY A;  3LQ0 A;  2CLT A;  3OHL A;  1H71 P;  4L6T A;  3ZUK A;  4G9L A;  1CIZ A;  1Y93 A;  3AYU A;  4QKZ A;  3EWJ A;  1OM6 A;  1FLS A;  3LKA A;  5CXA A;  3KEJ A;  1PWU A;  1XUD A;  3Q2G A;  3LUN A;  1OO9 A;  4HX3 A;  2OW1 A;  1FBL A;  1C3I A;  1GXD A;  3DL1 A;  1G4K A;  1EUB A;  4JPA A;  3F15 A;  2PJT A;  1AST A;  1ZS0 A;  2FV9 A;  2O3E A;  4HMA A;  1KUI A;  2AYK A;  3USN A;  2QPJ A;  1ZTQ A;  1XFZ A;  1D7X A;  4FXY P;  4IN9 A;  1IAG A;  1ZXC A;  5I12 A;  4IJO A;  5D1S A;  2K9C A;  1BQQ M;  1UTZ A;  5I43 A;  5L79 A;  3RTS A;  4AXQ A;  1MNC A;  1JAQ A;  1PWQ A;  3TT4 A;  3TVC A;  2WOA A;  4GR3 A;  2Z2D A;  1D8M A;  3LEA A;  3F19 A;  1IAC A;  4GWM A;  2O36 A;  3G42 A;  4PKV A;  2JIH A;  1ATL A;  1JIW P;  3KMC A;  1BZS A;  3HYG A;  4A3W A;  1OS2 A;  2OXU A;  1O0Q A;  3TS4 A;  1YP1 A;  1R1J A;  1GE5 A;  2JT5 A;  1GKD A;  1SAT A;  5CZM A;  3F16 A;  2Y6C A;  1KUH A;  4AIG A;  4PKQ A;  1MMB A;  1B8Y A;  5JMY A;  1I73 A;  5B5O A;  4J4M A;  2N8R A;  1GKC A;  2YIG A;  1AYK A;  5BOY A;  2OY4 A;  1K7G A;  2K2G A;  4H82 A;  2X7M A;  4FU4 A;  2DW1 A;  2MLS A;  1QJJ A;  1HOV A;  1QUA A;  1JAP A;  2DDY A;  2RJQ A;  3EHX A;  1IAE A;  5H8X A;  3VI1 A;  4JQG A;  3DPF A;  1JIZ A;  4PKW A;  1USN A;  1BSW A;  3ELM A;  2DW0 A;  4WKI A;  2V4B A;  3U1R A;  3EDG A;  3HDA P;  2DDF A;  1SU3 A;  1XUC A;  3LMC A;  3P24 A;  4XM7 A;  1UEA A;  4H2E A;  1IAD A;  3B2Z A;  1YQY A;  1ZXV A;  4IUW A;  3WV2 A;  1B3D A;  5D1U A;  1Q3A A;  1BKC A;  3BA0 A;  3CKI A;  4GR0 A;  1R1I A;  1PWW A;  1JK3 A;  2A8H A;  1G9K A;  1G12 A;  2JNP A;  2MZH A;  4CTH A;  1KUK A;  1BUV M;  2JT6 A;  2POJ A;  1SLM A;  1UMS A;  1QIC A;  2W15 A;  4GQL A;  1Y8J A;  2D1N A;  3LIR A;  2Y6D A;  3DNG A;  3K7N A;  3LQB A;  1CQR A;  830C A;  4PKS A;  4JA1 A;  2CKI A;  3B8Z A;  4L19 A;  4ON1 A;  3I7G A;  4GF1 A;  2J83 A;  1R1H A;  1GO8 P;  4JP4 A;  3HBU P;  4FXQ A;  3N2V A;  4GR8 A;  3DSL A;  2W0D A;  2OVX A;  3HY7 A;  4H3X A;  2SRT A;  3K7L A;  1MMP A;  4PKU A;  1Y0V A;  4G0D A;  2E2D A;  4PKR A;  1S4B P;  1XFX A;  2YB9 A;  2W13 A;  4I35 A;  5BOT A;  1XFY A;  1JKY A;  2OVZ A;  3I7I A;  4WKE A;  1BIW A;  4Q1L A;  1ROS A;  3B92 A;  4XCT A;  3L0V A;  3KME A;  3MA2 A;  3N2U A;  4WF6 A;  5D2B A;  1CAQ A;  5I0L A;  1C7K A;  1JJ9 A;  3EDI A;  4WK7 A;  1GE6 A;  3LE9 A;  3RTT A;  3EDZ A;  1GE7 A;  1XFU A;  2KRJ A;  2I47 A;  3HY9 A;  1IAB A;  5I4O A;  5LAB A;  2L0R A;  1XFV A;  2ERP A;  3Q2H A;  1EAK A;  2HU6 A;  4DV8 A;  2OW0 A;  1CGL A;  1D5J A;  1JH1 A;  1L6J A;  1BKC E;  1EB6 A;  2USN A;  3LK8 A;  3HDB A;  1UTT A;  1RMZ A;  1O0T A;  1OM7 A;  2ERO A;  2WO8 A;  4ZR5 A;  3AIG A;  1RM8 A;  1XFW A;  2WO9 A;  5CUH A;  1J7N A;  3VTG A;  1A85 A;  1HFS A;  4H49 A;  1BKC I;  3SHI A;  1AF0 A;  1BM6 A;  1SMP A;  2J0T A;  1C8T A;  3AYK A;  2X3B A;  5I2Z A;  1XUR A;  1MMQ A;  3ZXH A;  1JAN A;  3NX7 A;  4ILW D;  3WV3 A;  1QIB A;  1ZVX A;  4H76 A;  4XM6 A;  3DPE A;  4H30 A;  2TCL A;  4FVL A;  1QIA A;  3ZVS A;  4AYK A;  3TSK A;  3LJZ A;  3HB2 P;  1UMT A;  3HBV P;  1G05 A;  1IAA A;  2MLR A;  4WZV A;  1BUD A;  4DD8 A;  2X3C A;  2JSD A;  1CXV A;  1CGE A;  1I1I P;  2OI0 A;  3KRY A;  5B5P A;  3V96 B;  3LGP A;  1KUF A;  1WNI A;  3L0T A;  5D3C A;  5D7W A;  1YOU A;  3O64 A;  4GWN A;  2OZR A;  4DF9 A;  4AUO A;  4PKT A;  3E8R A;  3KWV C;  3F18 A;  2X3A A;  2OW2 A;  3F1A A;  2DW2 A;  4L63 A;  2RJP A;  4H1Q A;  3P1V A;  1DTH A;  3LJT A;  1ND1 A;  2D1O A;  4EFS A;  2MZI A;  1DMT A;  4H84 A;  1AKL A;  2ERQ A;  1K7Q A;  4A7B A;  1SRP A;  2FV5 A;  5BPA A;  1QJI A;  2XS3 A;  1PWV A;  3KEC A;  1K7I A;  1KBC A;  2OW9 A;  1HY7 A;  2MZE A;  3LIK A;  3LUM A;  1HTD A;  2W12 A;  4DPE A;  3LJG A;  2XS4 A;  3F17 A;  5L7F A;  1R55 A;  1MMR A;  1CGF A;  1KAP P;  4I03 A;  3LIL A;  1OM8 A;  3EDH A;  2OXW A;  4JIJ A;  3KEK A;  1YCM A;  1PWP A;  3UVC A;  1CK7 A;  3WV1 A;  5D1T A;  3O2X A;  5I3M A; 
#chains in the Genus database with same CATH topology
 4R3V A;  2W14 A;  1FM1 A;  1A86 A;  1R54 A;  1SLN A;  966C A;  1JAO A;  2AIG P;  1KUG A;  3KHI A;  1OS9 A;  4XM8 A;  1Z3J A;  3OHO A;  1D8F A;  1BQO A;  456C A;  2OXZ A;  1OMJ A;  1G49 A;  1HFC A;  2OY2 A;  3DWB A;  1ZP5 A;  1GO7 P;  1HV5 A;  3G5C A;  4XBH A;  1I76 A;  2E3X A;  3GBO A;  4GUY A;  3EHY A;  3LQ0 A;  2CLT A;  3OHL A;  3DTE A;  1H71 P;  4L6T A;  3ZUK A;  4G9L A;  1CIZ A;  1Y93 A;  3AYU A;  4QKZ A;  3EWJ A;  1OM6 A;  1FLS A;  3LKA A;  5CXA A;  3KEJ A;  1PWU A;  1XUD A;  3Q2G A;  4L7A A;  3LUN A;  1OO9 A;  4HX3 A;  2OW1 A;  1FBL A;  1C3I A;  1GXD A;  3DL1 A;  1G4K A;  1EUB A;  4JPA A;  3F15 A;  2PJT A;  1AST A;  1ZS0 A;  2FV9 A;  2O3E A;  4HMA A;  1KUI A;  2AYK A;  3USN A;  2QPJ A;  1ZTQ A;  1XFZ A;  1D7X A;  4FXY P;  4IN9 A;  1IAG A;  1ZXC A;  5I12 A;  4IJO A;  5D1S A;  2K9C A;  1BQQ M;  1UTZ A;  5I43 A;  5L79 A;  3RTS A;  4AXQ A;  1MNC A;  1JAQ A;  1PWQ A;  3TT4 A;  3TVC A;  2WOA A;  4GR3 A;  2Z2D A;  1D8M A;  3LEA A;  3F19 A;  1IAC A;  4GWM A;  2O36 A;  3G42 A;  4PKV A;  2JIH A;  1ATL A;  1JIW P;  3KMC A;  1BZS A;  3HYG A;  4A3W A;  1OS2 A;  2OXU A;  1O0Q A;  3TS4 A;  1YP1 A;  1R1J A;  1GE5 A;  2JT5 A;  1GKD A;  1SAT A;  1OZ9 A;  5CZM A;  3F16 A;  2Y6C A;  1KUH A;  4AIG A;  4PKQ A;  1MMB A;  1B8Y A;  5JMY A;  1I73 A;  5B5O A;  4J4M A;  2N8R A;  1GKC A;  2YIG A;  1AYK A;  5BOY A;  2OY4 A;  1K7G A;  2K2G A;  4H82 A;  2X7M A;  4FU4 A;  2DW1 A;  2MLS A;  1QJJ A;  1HOV A;  1QUA A;  1JAP A;  2DDY A;  2RJQ A;  3EHX A;  1IAE A;  5H8X A;  3VI1 A;  4JQG A;  3DPF A;  1JIZ A;  4PKW A;  1USN A;  1BSW A;  3ELM A;  2DW0 A;  4WKI A;  2V4B A;  3U1R A;  3EDG A;  3HDA P;  2DDF A;  1SU3 A;  1XUC A;  3LMC A;  3P24 A;  4XM7 A;  1UEA A;  4H2E A;  1IAD A;  3B2Z A;  1YQY A;  1ZXV A;  4IUW A;  3WV2 A;  1B3D A;  5D1U A;  1Q3A A;  1BKC A;  3BA0 A;  3CKI A;  4GR0 A;  1R1I A;  1PWW A;  2YUF A;  1JK3 A;  2A8H A;  1G9K A;  1G12 A;  2JNP A;  3DTK A;  2MZH A;  4CTH A;  1KUK A;  1BUV M;  2JT6 A;  2POJ A;  1SLM A;  1UMS A;  1QIC A;  2W15 A;  4GQL A;  1Y8J A;  1XM5 A;  2D1N A;  2Y6D A;  3LIR A;  3DNG A;  3K7N A;  3LQB A;  1CQR A;  830C A;  4PKS A;  4JA1 A;  2CKI A;  3B8Z A;  4L19 A;  4ON1 A;  3I7G A;  4GF1 A;  2J83 A;  1R1H A;  1GO8 P;  4JP4 A;  3HBU P;  4FXQ A;  3N2V A;  4GR8 A;  3DSL A;  2W0D A;  2OVX A;  3HY7 A;  4H3X A;  2SRT A;  3K7L A;  1MMP A;  4PKU A;  1Y0V A;  4G0D A;  2E2D A;  4PKR A;  1S4B P;  1XFX A;  2YB9 A;  2W13 A;  4I35 A;  5BOT A;  1XFY A;  1JKY A;  2OVZ A;  3I7I A;  4WKE A;  1BIW A;  4Q1L A;  1ROS A;  3B92 A;  4XCT A;  3L0V A;  3KME A;  3MA2 A;  3N2U A;  4WF6 A;  5D2B A;  1CAQ A;  5I0L A;  1C7K A;  1JJ9 A;  3EDI A;  4WK7 A;  1GE6 A;  3LE9 A;  3RTT A;  3EDZ A;  1GE7 A;  1XFU A;  2KRJ A;  2I47 A;  3HY9 A;  1IAB A;  5I4O A;  5LAB A;  2L0R A;  1XFV A;  2ERP A;  3Q2H A;  1EAK A;  2HU6 A;  4DV8 A;  2OW0 A;  1CGL A;  1D5J A;  1JH1 A;  1L6J A;  1BKC E;  1EB6 A;  2USN A;  3LK8 A;  3HDB A;  1UTT A;  1RMZ A;  1O0T A;  1OM7 A;  2ERO A;  2WO8 A;  4ZR5 A;  3AIG A;  1RM8 A;  1XFW A;  1XAX A;  2WO9 A;  5CUH A;  1J7N A;  3VTG A;  1A85 A;  1HFS A;  4H49 A;  1BKC I;  3SHI A;  1AF0 A;  1BM6 A;  1SMP A;  2J0T A;  1C8T A;  3AYK A;  2X3B A;  5I2Z A;  1XUR A;  1MMQ A;  3ZXH A;  1JAN A;  3NX7 A;  4ILW D;  3WV3 A;  1QIB A;  1ZVX A;  4H76 A;  4XM6 A;  3DPE A;  4H30 A;  2TCL A;  4FVL A;  1QIA A;  3ZVS A;  4AYK A;  3TSK A;  3LJZ A;  3HB2 P;  1UMT A;  3HBV P;  1G05 A;  1IAA A;  2MLR A;  4WZV A;  1BUD A;  4DD8 A;  2X3C A;  2JSD A;  1CXV A;  1CGE A;  1I1I P;  2OI0 A;  3DTI A;  3KRY A;  5B5P A;  3V96 B;  3LGP A;  1KUF A;  1WNI A;  3L0T A;  5D3C A;  5D7W A;  1YOU A;  3O64 A;  4GWN A;  2OZR A;  4DF9 A;  4AUO A;  4PKT A;  3E8R A;  3KWV C;  3F18 A;  2X3A A;  2OW2 A;  3F1A A;  2DW2 A;  4L63 A;  2RJP A;  4H1Q A;  3P1V A;  1DTH A;  3LJT A;  1ND1 A;  2D1O A;  4EFS A;  2MZI A;  1DMT A;  4H84 A;  1AKL A;  2ERQ A;  1K7Q A;  4A7B A;  1SRP A;  2FV5 A;  5BPA A;  1QJI A;  2XS3 A;  1PWV A;  3KEC A;  1K7I A;  1KBC A;  2OW9 A;  1HY7 A;  2MZE A;  3LIK A;  3LUM A;  1HTD A;  2W12 A;  4DPE A;  3LJG A;  2XS4 A;  3F17 A;  5L7F A;  1R55 A;  1MMR A;  1CGF A;  1TVI A;  1KAP P;  4I03 A;  3LIL A;  1OM8 A;  3EDH A;  2OXW A;  4JIJ A;  3KEK A;  1YCM A;  1PWP A;  3UVC A;  1CK7 A;  3WV1 A;  5D1T A;  3O2X A;  5I3M A; 
#chains in the Genus database with same CATH homology
 4R3V A;  2W14 A;  1FM1 A;  1A86 A;  1R54 A;  1SLN A;  966C A;  1JAO A;  2AIG P;  1KUG A;  3KHI A;  1OS9 A;  4XM8 A;  1Z3J A;  3OHO A;  1D8F A;  1BQO A;  456C A;  2OXZ A;  1OMJ A;  1G49 A;  1HFC A;  2OY2 A;  3DWB A;  1ZP5 A;  1GO7 P;  1HV5 A;  3G5C A;  4XBH A;  1I76 A;  2E3X A;  3GBO A;  4GUY A;  3EHY A;  3LQ0 A;  2CLT A;  3OHL A;  3DTE A;  1H71 P;  4L6T A;  3ZUK A;  4G9L A;  1CIZ A;  1Y93 A;  3AYU A;  4QKZ A;  3EWJ A;  1OM6 A;  1FLS A;  3LKA A;  5CXA A;  3KEJ A;  1PWU A;  1XUD A;  3Q2G A;  4L7A A;  3LUN A;  1OO9 A;  4HX3 A;  2OW1 A;  1FBL A;  1C3I A;  1GXD A;  3DL1 A;  1G4K A;  1EUB A;  4JPA A;  3F15 A;  2PJT A;  1AST A;  1ZS0 A;  2FV9 A;  2O3E A;  4HMA A;  1KUI A;  2AYK A;  3USN A;  2QPJ A;  1ZTQ A;  1XFZ A;  1D7X A;  4FXY P;  4IN9 A;  1IAG A;  1ZXC A;  5I12 A;  4IJO A;  5D1S A;  2K9C A;  1BQQ M;  1UTZ A;  5I43 A;  5L79 A;  3RTS A;  4AXQ A;  1MNC A;  1JAQ A;  1PWQ A;  3TT4 A;  3TVC A;  2WOA A;  4GR3 A;  2Z2D A;  1D8M A;  3LEA A;  3F19 A;  1IAC A;  4GWM A;  2O36 A;  3G42 A;  4PKV A;  2JIH A;  1ATL A;  1JIW P;  3KMC A;  1BZS A;  3HYG A;  4A3W A;  1OS2 A;  2OXU A;  1O0Q A;  3TS4 A;  1YP1 A;  1R1J A;  1GE5 A;  2JT5 A;  1GKD A;  1SAT A;  5CZM A;  3F16 A;  2Y6C A;  1KUH A;  4AIG A;  4PKQ A;  1MMB A;  1B8Y A;  5JMY A;  1I73 A;  5B5O A;  4J4M A;  2N8R A;  1GKC A;  2YIG A;  1AYK A;  5BOY A;  2OY4 A;  1K7G A;  2K2G A;  4H82 A;  2X7M A;  4FU4 A;  2DW1 A;  2MLS A;  1QJJ A;  1HOV A;  1QUA A;  1JAP A;  2DDY A;  2RJQ A;  3EHX A;  1IAE A;  5H8X A;  3VI1 A;  4JQG A;  3DPF A;  1JIZ A;  4PKW A;  1USN A;  1BSW A;  3ELM A;  2DW0 A;  4WKI A;  2V4B A;  3U1R A;  3EDG A;  3HDA P;  2DDF A;  1SU3 A;  1XUC A;  3LMC A;  3P24 A;  4XM7 A;  1UEA A;  4H2E A;  1IAD A;  3B2Z A;  1YQY A;  1ZXV A;  4IUW A;  3WV2 A;  1B3D A;  5D1U A;  1Q3A A;  1BKC A;  3BA0 A;  3CKI A;  4GR0 A;  1R1I A;  1PWW A;  2YUF A;  1JK3 A;  2A8H A;  1G9K A;  1G12 A;  2JNP A;  3DTK A;  2MZH A;  4CTH A;  1KUK A;  1BUV M;  2JT6 A;  2POJ A;  1SLM A;  1UMS A;  1QIC A;  2W15 A;  4GQL A;  1Y8J A;  2D1N A;  3LIR A;  2Y6D A;  3DNG A;  3K7N A;  3LQB A;  1CQR A;  830C A;  4PKS A;  4JA1 A;  2CKI A;  3B8Z A;  4L19 A;  4ON1 A;  3I7G A;  4GF1 A;  2J83 A;  1R1H A;  1GO8 P;  4JP4 A;  3HBU P;  4FXQ A;  3N2V A;  4GR8 A;  3DSL A;  2W0D A;  2OVX A;  3HY7 A;  4H3X A;  2SRT A;  3K7L A;  1MMP A;  4PKU A;  1Y0V A;  4G0D A;  2E2D A;  4PKR A;  1S4B P;  1XFX A;  2YB9 A;  2W13 A;  4I35 A;  5BOT A;  1XFY A;  1JKY A;  2OVZ A;  3I7I A;  4WKE A;  1BIW A;  4Q1L A;  1ROS A;  3B92 A;  4XCT A;  3L0V A;  3KME A;  3MA2 A;  3N2U A;  4WF6 A;  5D2B A;  1CAQ A;  5I0L A;  1C7K A;  1JJ9 A;  3EDI A;  4WK7 A;  1GE6 A;  3LE9 A;  3RTT A;  3EDZ A;  1GE7 A;  1XFU A;  2KRJ A;  2I47 A;  3HY9 A;  1IAB A;  5I4O A;  5LAB A;  2L0R A;  1XFV A;  2ERP A;  3Q2H A;  1EAK A;  2HU6 A;  4DV8 A;  2OW0 A;  1CGL A;  1D5J A;  1JH1 A;  1L6J A;  1BKC E;  1EB6 A;  2USN A;  3LK8 A;  3HDB A;  1UTT A;  1RMZ A;  1O0T A;  1OM7 A;  2ERO A;  2WO8 A;  4ZR5 A;  3AIG A;  1RM8 A;  1XFW A;  2WO9 A;  5CUH A;  1J7N A;  3VTG A;  1A85 A;  1HFS A;  4H49 A;  1BKC I;  3SHI A;  1AF0 A;  1BM6 A;  1SMP A;  2J0T A;  1C8T A;  3AYK A;  2X3B A;  5I2Z A;  1XUR A;  1MMQ A;  3ZXH A;  1JAN A;  3NX7 A;  4ILW D;  3WV3 A;  1QIB A;  1ZVX A;  4H76 A;  4XM6 A;  3DPE A;  4H30 A;  2TCL A;  4FVL A;  1QIA A;  3ZVS A;  4AYK A;  3TSK A;  3LJZ A;  3HB2 P;  1UMT A;  3HBV P;  1G05 A;  1IAA A;  2MLR A;  4WZV A;  1BUD A;  4DD8 A;  2X3C A;  2JSD A;  1CXV A;  1CGE A;  1I1I P;  2OI0 A;  3DTI A;  3KRY A;  5B5P A;  3V96 B;  3LGP A;  1KUF A;  1WNI A;  3L0T A;  5D3C A;  5D7W A;  1YOU A;  3O64 A;  4GWN A;  2OZR A;  4DF9 A;  4AUO A;  4PKT A;  3E8R A;  3KWV C;  3F18 A;  2X3A A;  2OW2 A;  3F1A A;  2DW2 A;  4L63 A;  2RJP A;  4H1Q A;  3P1V A;  1DTH A;  3LJT A;  1ND1 A;  2D1O A;  4EFS A;  2MZI A;  1DMT A;  4H84 A;  1AKL A;  2ERQ A;  1K7Q A;  4A7B A;  1SRP A;  2FV5 A;  5BPA A;  1QJI A;  2XS3 A;  1PWV A;  3KEC A;  1K7I A;  1KBC A;  2OW9 A;  1HY7 A;  2MZE A;  3LIK A;  3LUM A;  1HTD A;  2W12 A;  4DPE A;  3LJG A;  2XS4 A;  3F17 A;  5L7F A;  1R55 A;  1MMR A;  1CGF A;  1KAP P;  4I03 A;  3LIL A;  1OM8 A;  3EDH A;  2OXW A;  4JIJ A;  3KEK A;  1YCM A;  1PWP A;  3UVC A;  1CK7 A;  3WV1 A;  5D1T A;  3O2X A;  5I3M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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