3CW7A

Crystal structure of an alka host/guest complex 8oxoguanine:cytosine base pair
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Escherichia coli
molecule keywords DNA-3-methyladenine glycosylase 2
total genus 88
structure length 282
sequence length 282
chains with identical sequence B, C, D
ec nomenclature ec 3.2.2.21: DNA-3-methyladenine glycosylase II.
pdb deposition date 2008-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein
A PF06029 AlkA_N AlkA N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 3cw7A02
1.10.1670.10 Mainly Alpha Orthogonal Bundle Endonuclease Iii, domain 2 Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) 3cw7A03
3.30.310.20 Alpha Beta 2-Layer Sandwich TATA-Binding Protein DNA-3-methyladenine glycosylase AlkA, N-terminal domain 3cw7A01
3D4VA 2NOHA 4EW4A 4B24A 1MUNA 4AI5A 3OGDA 4EA5A 3FHFA 2NOEA 2OFKA 3CWAA 2I5WA 1PU7A 2OFIA 3FSPA 4AIAA 4OFHA 1KG7A 4E9EA 4DK9A 1FN7A 4EJYA 2JHNA 1VRLA 1N3CA 3IH7A 1HU0A 1KG5A 1PU8A 1XG7A 5AN4A 4E9FA 1WEGA 3IHOA 3CWUA 4EVVA 1P59A 2XHIA 1N3AA 3CW7A 1KG6A 1YQLA 2NOBA 3CWSA 1MPGA 1WEIA 2H56A 1YQMA 4UNFA 2NOIA 3FHGA 3OH6A 5DPKA 1ORNA 4OFAA 1YQKA 1M3HA 3CVSA 1PVSA 2YG8A 1M3QA 1PU6A 1XQPA 2NOZA 1N39A 1LWYA 4OFEA 4B23A 1KEAA 3G0QA 4E9HA 1P7MA 4E9GA 4YOQA 4EA4A 2JG6A 1KG3A 3F0ZA 1NGNA 2JHJA 2NOLA 5KN8A 4EW0A 1DIZA 4HSBA 3F10A 1LMZA 3N0UA 4B21A 1MUDA 3S6IA 4B22A 1NKUA 1ORPA 1KG4A 3KTUA 4YPRA 1LWVA 4YPHA 1MUYA 1KO9A 5KN9A 1EBMA 1KG2A 3I0WA 3N5NX 2ABKA 1LWWA 1XQOA 3CWTA 3CVTA 1RRSA 4PIIA 5CHZA 3KNTA 4UOBA 3OH9A 1YQRA 2YG9A 4AI4A 1RRQA 3I0XA 4EJZA 2NOFA 1WEFA 1KQJA
chains in the Genus database with same CATH superfamily
3OY9A 4NZGA 2QREA 1TBPA 4EA5A 3OYAA 2I5WA 4EAJA 1M5Q1 5IYBP 1NVPA 3RPJA 3OS1A 1K2YX 2JHNA 1HU0A 1KG5A 1TBAB 2H5AX 2OOYA 3IHOA 1KG6A 1VTOA 1WQAA 4QG5A 1YQLA 2PWWA 2YH5A 1QNAA 3CWSA 2HL9A 3TDHA 1YQMA 1D3UA 4IL8A 4BDZA 5DPKA 3OLPA 4OFAA 1M3QA 1E42A 2QLVA 4D7QA 3OSMA 4Q11A 1YTBA 1N39A 4OFEA 4B23A 2JPSA 1JDYA 1VTLE 2JG6A 5JMVD 3C04A 5KN8A 4BACA 1UL7A 4B22A 1ORPA 1QN8A 3OYDA 4YPRA 3NNQA 1LWVA 3OYJA 2JOIA 1MUYA 3N5NX 3CWTA 1QTSA 2R5XA 1KFIA 4EAIA 2V9JA 1XSZA 3EAYA 1YQRA 4AI4A 3OS0A 3KRMA 3VW4A 2NOHA 1QTPA 1MUNA 3R2XC 1KY6A 1CDWA 3FSPA 2DKAA 3OYGA 2HZMA 3OYNA 4E7KA 1KG7A 4EJYA 1U84A 3LCNA 1XG7A 4ROCB 3I3WA 4EVVA 1P59A 3CW7A 3OYIA 4ZTFA 1WEIA 3TE5A 3ULXA 5HSHA 2NOIA 4EALA 1QN3A 2O3OA 4HJHA 1YQKA 2IV8A 1M3HA 3CVSA 1PU6A 2QRCA 2OOXA 1QN4A 2F7LA 2FKFA 1P5DX 3G0QA 4E9HA 1T6AA 1QN7A 3OYKA 4E7HA 3HS9A 1UT4A 3EIKA 1NGNA 1PZDA 4I8OA 3T4NA 3VN5A 3N89A 3N0UA 3RSMA 1MUDA 3L2QA 4RODB 1KG4A 2H4LX 1KYFA 2V75A 4YPHA 2DKDA 1KO9A 4TPSA 1QNBA 4EAKA 1QN5A 3I0WA 2HZSA 1XQOA 2JPIA 2MZ8A 4BE0A 1YTFA 3CVTA 3UW2A 1RRSA 4PIIA 1C47A 4UOBA 4CFFA 1RRQA 1KYDA 2D0BA 3OYLA 4EW4A 2HL8A 4E7LA 4AI5A 3OGDA 2NOEA 3FHFA 5FROA 2OFKA 1PU7A 2OFIA 1NGMA 4OFHA 2W03A 2Y8QA 3D7QA 4DK9A 1N3CA 4E7IA 3BKQX 5AN4A 2EHBD 3S3NA 4C7PA 2NWVA 2IV9A 3S3OA 2YA3A 1P5GX 1MPGA 1TGHA 4ROEB 1PCZA 3FHGA 4BE2A 3NA5A 2YG8A 2ZFDB 1XQPA 2NOZA 2FGTA 4BE1A 1EUVA 3PDKA 4E9GA 4YOQA 3OYHA 4EA4A 2DKCA 5BMNA 4D7RA 4EAGA 2D0CA 2JHJA 2NOLA 3OSTA 5KL0A 1DIZA 4HSBA 3F10A 2Y8LA 4B21A 3S6IA 3HS8A 1C4GA 1J3MA 4DULA 1QNEA 3OYBA 2HKPA 3S3MA 1AISA 5KN9A 1UT7A 1C9BB 3PMGA 2NLVA 2ABKA 1PCJX 5FRMA 1VKLA 3KNTA 2MJ7A 3OH9A 2FUVA 3OS2A 3SNSA 2NOFA 1TUOA 1P7MA 1KQJA 3D4VA 1PCMX 3DPUA 4B24A 4BJUA 4ZTJA 1W80A 2D0AA 5EPCA 3CWAA 3OYFA 3ASMA 4AIAA 4IKFA 4MRQA 5JN5A 2V92A 2FKMX 4E7JA 3ENOC 4WXAA 4E9EA 1FN7A 1WJWA 1VRLA 2Z8UA 3IH7A 1PU8A 4E9FA 1WEGA 3CWUA 1MP9A 3OYEA 2XHIA 3L2WA 1QN9A 1N3AA 1VOLB 2NVMA 1Q9UA 5IYDP 3DPTA 2NOBA 5BMPA 2W04A 2LAEA 2H56A 1NH2A 3ENCA 4UNFA 2VJ0A 3OH6A 1ORNA 1QNCA 4WZSD 1PVSA 5F9CA 1LXTA 1QN6A 2V8QA 1LWYA 1R4XA 3OCIA 1KEAA 4B0AA 1KFQA 3OYMA 5IYCP 3L2RA 1KG3A 3F0ZA 1KYUA 4EW0A 1LMZA 4PY5A 2QR1A 4BDYA 3OSEA 3L2UA 1NKUA 3L2VA 1V5SA 3KTUA 1JFIC 2G30A 1B9KA 3H1ZA 4WX8A 1RM1A 5FRNA 3OYCA 1EBMA 1KG2A 1LWWA 1K35A 1VOKA 2Z0FA 1KY7A 5CHZA 2QRDA 3OC3C 2YG9A 3I0XA 4EJZA 1WEFA
chains in the Genus database with same CATH topology
3D4VA 2NOHA 4EW4A 4B24A 1MUNA 4AI5A 3OGDA 4EA5A 3FHFA 2NOEA 2OFKA 3CWAA 2I5WA 1PU7A 2OFIA 3FSPA 4AIAA 4OFHA 1KG7A 4E9EA 4DK9A 1FN7A 4EJYA 2JHNA 1VRLA 1N3CA 3IH7A 1HU0A 1KG5A 1PU8A 1XG7A 5AN4A 4E9FA 1WEGA 3IHOA 3CWUA 4EVVA 1P59A 2XHIA 1N3AA 3CW7A 1KG6A 1YQLA 2NOBA 3CWSA 1MPGA 1WEIA 2H56A 1YQMA 4UNFA 2NOIA 3FHGA 3OH6A 5DPKA 1ORNA 4OFAA 1YQKA 1M3HA 3CVSA 1PVSA 2YG8A 1M3QA 1PU6A 1XQPA 2NOZA 1N39A 1LWYA 4OFEA 4B23A 1KEAA 3G0QA 4E9HA 1P7MA 4E9GA 4YOQA 4EA4A 2JG6A 1KG3A 3F0ZA 1NGNA 2JHJA 2NOLA 5KN8A 4EW0A 1DIZA 4HSBA 3F10A 1LMZA 3N0UA 4B21A 1MUDA 3S6IA 4B22A 1NKUA 1ORPA 1KG4A 3KTUA 4YPRA 1LWVA 4YPHA 1MUYA 1KO9A 5KN9A 1EBMA 1KG2A 3I0WA 3N5NX 2ABKA 1LWWA 1XQOA 3CWTA 3CVTA 1RRSA 4PIIA 5CHZA 3KNTA 4UOBA 3OH9A 1YQRA 2YG9A 4AI4A 1RRQA 3I0XA 4EJZA 2NOFA 1WEFA 1KQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D4V A;  2NOH A;  4EW4 A;  4B24 A;  1MUN A;  4AI5 A;  3OGD A;  4EA5 A;  3FHF A;  2NOE A;  2OFK A;  3CWA A;  2I5W A;  1PU7 A;  2OFI A;  3FSP A;  4AIA A;  4OFH A;  1KG7 A;  4E9E A;  4DK9 A;  1FN7 A;  4EJY A;  2JHN A;  1VRL A;  1N3C A;  3IH7 A;  1HU0 A;  1KG5 A;  1PU8 A;  1XG7 A;  5AN4 A;  4E9F A;  1WEG A;  3IHO A;  3CWU A;  4EVV A;  1P59 A;  2XHI A;  1N3A A;  3CW7 A;  1KG6 A;  1YQL A;  2NOB A;  3CWS A;  1MPG A;  1WEI A;  2H56 A;  1YQM A;  4UNF A;  2NOI A;  3FHG A;  3OH6 A;  5DPK A;  1ORN A;  4OFA A;  1YQK A;  1M3H A;  3CVS A;  1PVS A;  2YG8 A;  1M3Q A;  1PU6 A;  1XQP A;  2NOZ A;  1N39 A;  1LWY A;  4OFE A;  4B23 A;  1KEA A;  3G0Q A;  4E9H A;  1P7M A;  4E9G A;  4YOQ A;  4EA4 A;  2JG6 A;  1KG3 A;  3F0Z A;  1NGN A;  2JHJ A;  2NOL A;  5KN8 A;  4EW0 A;  1DIZ A;  4HSB A;  3F10 A;  1LMZ A;  3N0U A;  4B21 A;  1MUD A;  3S6I A;  4B22 A;  1NKU A;  1ORP A;  1KG4 A;  3KTU A;  4YPR A;  1LWV A;  4YPH A;  1MUY A;  1KO9 A;  5KN9 A;  1EBM A;  1KG2 A;  3I0W A;  3N5N X;  2ABK A;  1LWW A;  1XQO A;  3CWT A;  3CVT A;  1RRS A;  4PII A;  5CHZ A;  3KNT A;  4UOB A;  3OH9 A;  1YQR A;  2YG9 A;  4AI4 A;  1RRQ A;  3I0X A;  4EJZ A;  2NOF A;  1WEF A;  1KQJ A; 
#chains in the Genus database with same CATH topology
 3OY9 A;  4NZG A;  2QRE A;  1TBP A;  4EA5 A;  3OYA A;  2I5W A;  4EAJ A;  1M5Q 1;  5IYB P;  1NVP A;  3RPJ A;  3OS1 A;  1K2Y X;  2JHN A;  1HU0 A;  1KG5 A;  1TBA B;  2H5A X;  2OOY A;  3IHO A;  1KG6 A;  1VTO A;  1WQA A;  4QG5 A;  1YQL A;  2PWW A;  2YH5 A;  1QNA A;  3CWS A;  2HL9 A;  3TDH A;  1YQM A;  1D3U A;  4IL8 A;  4BDZ A;  5DPK A;  3OLP A;  4OFA A;  1M3Q A;  1E42 A;  2QLV A;  4D7Q A;  3OSM A;  4Q11 A;  1YTB A;  1N39 A;  4OFE A;  4B23 A;  2JPS A;  1JDY A;  1VTL E;  2JG6 A;  5JMV D;  3C04 A;  5KN8 A;  4BAC A;  1UL7 A;  4B22 A;  1ORP A;  1QN8 A;  3OYD A;  4YPR A;  3NNQ A;  1LWV A;  3OYJ A;  2JOI A;  1MUY A;  3N5N X;  3CWT A;  1QTS A;  2R5X A;  1KFI A;  4EAI A;  2V9J A;  1XSZ A;  3EAY A;  1YQR A;  4AI4 A;  3OS0 A;  3KRM A;  3VW4 A;  2NOH A;  1QTP A;  1MUN A;  3R2X C;  1KY6 A;  1CDW A;  3FSP A;  2DKA A;  3OYG A;  2HZM A;  3OYN A;  4E7K A;  1KG7 A;  4EJY A;  1U84 A;  3LCN A;  1XG7 A;  4ROC B;  3I3W A;  4EVV A;  1P59 A;  3CW7 A;  3OYI A;  4ZTF A;  1WEI A;  3TE5 A;  3ULX A;  5HSH A;  2NOI A;  4EAL A;  1QN3 A;  2O3O A;  4HJH A;  1YQK A;  2IV8 A;  1M3H A;  3CVS A;  1PU6 A;  2QRC A;  2OOX A;  1QN4 A;  2F7L A;  2FKF A;  1P5D X;  3G0Q A;  4E9H A;  1T6A A;  1QN7 A;  3OYK A;  4E7H A;  3HS9 A;  1UT4 A;  3EIK A;  1NGN A;  1PZD A;  4I8O A;  3T4N A;  3VN5 A;  3N89 A;  3N0U A;  3RSM A;  1MUD A;  3L2Q A;  4ROD B;  1KG4 A;  2H4L X;  1KYF A;  2V75 A;  4YPH A;  2DKD A;  1KO9 A;  4TPS A;  1QNB A;  4EAK A;  1QN5 A;  3I0W A;  2HZS A;  1XQO A;  2JPI A;  2MZ8 A;  4BE0 A;  1YTF A;  3CVT A;  3UW2 A;  1RRS A;  4PII A;  1C47 A;  4UOB A;  4CFF A;  1RRQ A;  1KYD A;  2D0B A;  3OYL A;  4EW4 A;  2HL8 A;  4E7L A;  4AI5 A;  3OGD A;  2NOE A;  3FHF A;  5FRO A;  2OFK A;  1PU7 A;  2OFI A;  1NGM A;  4OFH A;  2W03 A;  2Y8Q A;  3D7Q A;  4DK9 A;  1N3C A;  4E7I A;  3BKQ X;  5AN4 A;  2EHB D;  3S3N A;  4C7P A;  2NWV A;  2IV9 A;  3S3O A;  2YA3 A;  1P5G X;  1MPG A;  1TGH A;  4ROE B;  1PCZ A;  3FHG A;  4BE2 A;  3NA5 A;  2YG8 A;  2ZFD B;  1XQP A;  2NOZ A;  2FGT A;  4BE1 A;  1EUV A;  3PDK A;  4E9G A;  4YOQ A;  3OYH A;  4EA4 A;  2DKC A;  5BMN A;  4D7R A;  4EAG A;  2D0C A;  2JHJ A;  2NOL A;  3OST A;  5KL0 A;  1DIZ A;  4HSB A;  3F10 A;  2Y8L A;  4B21 A;  3S6I A;  3HS8 A;  1C4G A;  1J3M A;  4DUL A;  1QNE A;  3OYB A;  2HKP A;  3S3M A;  1AIS A;  5KN9 A;  1UT7 A;  1C9B B;  3PMG A;  2NLV A;  2ABK A;  1PCJ X;  5FRM A;  1VKL A;  3KNT A;  2MJ7 A;  3OH9 A;  2FUV A;  3OS2 A;  3SNS A;  2NOF A;  1TUO A;  1P7M A;  1KQJ A;  3D4V A;  1PCM X;  3DPU A;  4B24 A;  4BJU A;  4ZTJ A;  1W80 A;  2D0A A;  5EPC A;  3CWA A;  3OYF A;  3ASM A;  4AIA A;  4IKF A;  4MRQ A;  5JN5 A;  2V92 A;  2FKM X;  4E7J A;  3ENO C;  4WXA A;  4E9E A;  1FN7 A;  1WJW A;  1VRL A;  2Z8U A;  3IH7 A;  1PU8 A;  4E9F A;  1WEG A;  3CWU A;  1MP9 A;  3OYE A;  2XHI A;  3L2W A;  1QN9 A;  1N3A A;  1VOL B;  2NVM A;  1Q9U A;  5IYD P;  3DPT A;  2NOB A;  5BMP A;  2W04 A;  2LAE A;  2H56 A;  1NH2 A;  3ENC A;  4UNF A;  2VJ0 A;  3OH6 A;  1ORN A;  1QNC A;  4WZS D;  1PVS A;  5F9C A;  1LXT A;  1QN6 A;  2V8Q A;  1LWY A;  1R4X A;  3OCI A;  1KEA A;  4B0A A;  1KFQ A;  3OYM A;  5IYC P;  3L2R A;  1KG3 A;  3F0Z A;  1KYU A;  4EW0 A;  1LMZ A;  4PY5 A;  2QR1 A;  4BDY A;  3OSE A;  3L2U A;  1NKU A;  3L2V A;  1V5S A;  3KTU A;  1JFI C;  2G30 A;  1B9K A;  3H1Z A;  4WX8 A;  1RM1 A;  5FRN A;  3OYC A;  1EBM A;  1KG2 A;  1LWW A;  1K35 A;  1VOK A;  2Z0F A;  1KY7 A;  5CHZ A;  2QRD A;  3OC3 C;  2YG9 A;  3I0X A;  4EJZ A;  1WEF A; 
#chains in the Genus database with same CATH homology
 3D4V A;  2NOH A;  4EW4 A;  4B24 A;  1MUN A;  4AI5 A;  3OGD A;  4EA5 A;  3FHF A;  2NOE A;  2OFK A;  3CWA A;  2I5W A;  1PU7 A;  2OFI A;  3FSP A;  4AIA A;  4OFH A;  1KG7 A;  4E9E A;  4DK9 A;  1FN7 A;  4EJY A;  2JHN A;  1VRL A;  1N3C A;  3IH7 A;  1HU0 A;  1KG5 A;  1PU8 A;  1XG7 A;  5AN4 A;  4E9F A;  1WEG A;  3IHO A;  3CWU A;  4EVV A;  1P59 A;  2XHI A;  1N3A A;  3CW7 A;  1KG6 A;  1YQL A;  2NOB A;  3CWS A;  1MPG A;  1WEI A;  2H56 A;  1YQM A;  4UNF A;  2NOI A;  3FHG A;  3OH6 A;  5DPK A;  1ORN A;  4OFA A;  1YQK A;  1M3H A;  3CVS A;  1PVS A;  2YG8 A;  1M3Q A;  1PU6 A;  1XQP A;  2NOZ A;  1N39 A;  1LWY A;  4OFE A;  4B23 A;  1KEA A;  3G0Q A;  4E9H A;  1P7M A;  4E9G A;  4YOQ A;  4EA4 A;  2JG6 A;  1KG3 A;  3F0Z A;  1NGN A;  2JHJ A;  2NOL A;  5KN8 A;  4EW0 A;  1DIZ A;  4HSB A;  3F10 A;  1LMZ A;  3N0U A;  4B21 A;  1MUD A;  3S6I A;  4B22 A;  1NKU A;  1ORP A;  1KG4 A;  3KTU A;  4YPR A;  1LWV A;  4YPH A;  1MUY A;  1KO9 A;  5KN9 A;  1EBM A;  1KG2 A;  3I0W A;  3N5N X;  2ABK A;  1LWW A;  1XQO A;  3CWT A;  3CVT A;  1RRS A;  4PII A;  5CHZ A;  3KNT A;  4UOB A;  3OH9 A;  1YQR A;  2YG9 A;  4AI4 A;  1RRQ A;  3I0X A;  4EJZ A;  2NOF A;  1WEF A;  1KQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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