3CWAA

Crystal structure of an alka host/guest complex 8oxoguanine:cytosine base pair
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
282
structure length
282
Chain Sequence
MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Escherichia coli
molecule keywords DNA-3-methyladenine glycosylase 2
total genus 94
structure length 282
sequence length 282
chains with identical sequence B, C, D
ec nomenclature ec 3.2.2.21: DNA-3-methyladenine glycosylase II.
pdb deposition date 2008-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein
A PF06029 AlkA_N AlkA N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 3cwaA02
1.10.1670.10 Mainly Alpha Orthogonal Bundle Endonuclease Iii, domain 2 Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) 3cwaA03
3.30.310.20 Alpha Beta 2-Layer Sandwich TATA-Binding Protein DNA-3-methyladenine glycosylase AlkA, N-terminal domain 3cwaA01
1LWYA 2YG9A 1KG4A 4YOQA 4E9HA 4YPHA 4AI4A 4HSBA 4DK9A 2JHNA 3CWAA 1MUDA 3OH9A 5CHZA 3CWTA 1NKUA 4EW4A 4YPRA 4AIAA 4B21A 1KG7A 4EVVA 2NOIA 2H56A 4E9EA 2I5WA 1ORPA 3CVSA 2NOHA 3G0QA 3I0WA 3KTUA 1VRLA 4EJZA 1YQMA 1PU8A 1KQJA 3CW7A 4B24A 4EJYA 1KO9A 1EBMA 2ABKA 1N3AA 1XG7A 4UOBA 2NOBA 5AN4A 3S6IA 2NOZA 2OFKA 4EA4A 1MUYA 1YQRA 4OFAA 4EW0A 1KG5A 2NOEA 1LMZA 1XQPA 2OFIA 1HU0A 1P59A 4UNFA 2YG8A 5KN9A 3FHFA 1RRSA 2NOLA 3FSPA 1MPGA 4PIIA 4E9FA 1PU7A 3N0UA 1M3QA 2JHJA 4AI5A 1RRQA 1PU6A 4B23A 1M3HA 1YQKA 3CWSA 1ORNA 1WEGA 1DIZA 1KG3A 3OGDA 2JG6A 5DPKA 1YQLA 3IH7A 1WEFA 1N3CA 1KG2A 3I0XA 3IHOA 1XQOA 1WEIA 1FN7A 1P7MA 1N39A 4OFHA 3FHGA 4EA5A 4E9GA 2XHIA 3CWUA 1KEAA 3KNTA 4OFEA 1MUNA 3CVTA 3F10A 1LWVA 3D4VA 4B22A 1KG6A 1NGNA 3F0ZA 3N5NX 3OH6A 5KN8A 1LWWA 1PVSA 2NOFA
chains in the Genus database with same CATH superfamily
1LWYA 4EAGA 2HZSA 4D7QA 1P5GX 3ENOC 4YPHA 2FKFA 2JHNA 3L2WA 4B21A 3OYIA 2QLVA 2H56A 1J3MA 3KTUA 4ZTFA 4C7PA 2ABKA 2NWVA 1XG7A 2NOZA 1KY6A 1TBAB 4EA4A 2F7LA 5BMNA 2FGTA 3OSEA 1LMZA 4BE0A 4BDYA 1K35A 2YG8A 3FHFA 1TGHA 2OOYA 4BACA 2NOLA 1MPGA 1M5Q1 1PU7A 5BMPA 4BDZA 3OYCA 1ORNA 1DIZA 4EAJA 3OYHA 3OGDA 2JG6A 2Y8QA 5HSHA 2HL8A 4HJHA 1VKLA 4E7KA 1KG2A 4QG5A 3OS1A 3L2QA 2H4LX 4OFHA 2YA3A 3FHGA 3OYNA 3D7QA 1JFIC 3KNTA 3D4VA 1UT4A 3L2UA 1RM1A 4WX8A 1TUOA 3RPJA 2NOFA 2YG9A 1Q9UA 5EPCA 1B9KA 2IV8A 4DK9A 3CWAA 1KYUA 5CHZA 3CWTA 1QN6A 5F9CA 1ORPA 3I0WA 1VRLA 1T6AA 4EAIA 2LAEA 4EAKA 3OYDA 3VW4A 1KO9A 3OY9A 1EBMA 3EIKA 2JPIA 3OYGA 3KRMA 2W04A 1MUYA 1QNCA 4EW0A 1NVPA 5FROA 2V9JA 1XQPA 2QR1A 5KN9A 3OYAA 1V5SA 3ULXA 3OYLA 4EALA 4E9FA 1XSZA 1QN4A 2HZMA 2V8QA 1M3HA 4B23A 3OS0A 1WEGA 2V92A 3R2XC 5KL0A 3S3OA 1E42A 5IYDP 2VJ0A 1VOLB 1QTSA 1WEFA 3I0XA 3IHOA 2NLVA 1WEIA 1FN7A 1P7MA 1PCZA 4ROEB 4EA5A 1LXTA 1KFQA 3OCIA 1QNBA 2XHIA 4D7RA 3TE5A 3L2VA 3NNQA 2NVMA 2O3OA 2W03A 3F10A 1PCMX 1D3UA 1KG6A 1LWWA 3OC3C 3OH6A 1PVSA 2DKDA 3HS8A 2R5XA 2IV9A 2Z0FA 1KG4A 1UT7A 4E9HA 4AI4A 4HSBA 5JN5A 1NKUA 5JMVD 4EW4A 4YPRA 4ROCB 1QN7A 4IKFA 4E9EA 2I5WA 1U84A 3G0QA 4E7JA 4I8OA 3OYJA 1YTBA 1YQMA 1QN8A 3CW7A 1QN5A 4EJYA 3OSMA 2JOIA 1W80A 2NOBA 5AN4A 3S6IA 5FRNA 3ENCA 4OFAA 3PMGA 5IYCP 5FRMA 1YTFA 1UL7A 1JDYA 1HU0A 1P59A 4UNFA 1KYDA 4CFFA 2HKPA 3DPUA 1KY7A 2V75A 3FSPA 4PIIA 3HS9A 1CDWA 4BE2A 3OSTA 1M3QA 2JHJA 4AI5A 4BE1A 2D0BA 2QRDA 3RSMA 1C4GA 2OOXA 1PU6A 3CWSA 1P5DX 1WJWA 3IH7A 3OLPA 1K2YX 1MP9A 2H5AX 4WXAA 1NGMA 1C47A 5IYBP 1XQOA 3OYBA 2YH5A 1PZDA 2EHBD 1VTLE 4E9GA 1EUVA 3T4NA 3N89A 1KEAA 1VOKA 1WQAA 4OFEA 1MUNA 4E7HA 3OYMA 1QTPA 1QN3A 3S3NA 3PDKA 5KN8A 4ZTJA 2Z8UA 4Q11A 2FUVA 1QNEA 4YOQA 4PY5A 2ZFDB 3ASMA 4IL8A 1TBPA 4WZSD 3VN5A 1MUDA 3OH9A 1KYFA 3H1ZA 2MJ7A 1QNAA 4AIAA 4EVVA 1KG7A 2NOIA 2DKAA 4BJUA 3CVSA 2NOHA 3TDHA 4EJZA 4E7IA 1PU8A 1KQJA 1PCJX 4B24A 2QREA 1NH2A 4E7LA 3OYKA 1N3AA 4UOBA 2HL9A 2Y8LA 4TPSA 2OFKA 2D0AA 2PWWA 3EAYA 3L2RA 3BKQX 3C04A 1YQRA 2JPSA 1KG5A 2NOEA 4B0AA 2MZ8A 2OFIA 2D0CA 3NA5A 1RRSA 2QRCA 4NZGA 3N0UA 2DKCA 1RRQA 1YQKA 3LCNA 3OYEA 1KG3A 1VTOA 3S3MA 1QN9A 5DPKA 1R4XA 4RODB 1YQLA 3I3WA 1N3CA 1C9BB 2G30A 1N39A 4MRQA 4DULA 2FKMX 3UW2A 3DPTA 3CWUA 3SNSA 1AISA 1KFIA 3OYFA 3CVTA 1LWVA 3OS2A 1NGNA 4B22A 3N5NX 3F0ZA
chains in the Genus database with same CATH topology
1LWYA 2YG9A 1KG4A 4YOQA 4E9HA 4YPHA 4AI4A 4HSBA 4DK9A 2JHNA 3CWAA 1MUDA 3OH9A 5CHZA 3CWTA 1NKUA 4EW4A 4YPRA 4AIAA 4B21A 1KG7A 4EVVA 2NOIA 2H56A 4E9EA 2I5WA 1ORPA 3CVSA 2NOHA 3G0QA 3I0WA 3KTUA 1VRLA 4EJZA 1YQMA 1PU8A 1KQJA 3CW7A 4B24A 4EJYA 1KO9A 1EBMA 2ABKA 1N3AA 1XG7A 4UOBA 2NOBA 5AN4A 3S6IA 2NOZA 2OFKA 4EA4A 1MUYA 1YQRA 4OFAA 4EW0A 1KG5A 2NOEA 1LMZA 1XQPA 2OFIA 1HU0A 1P59A 4UNFA 2YG8A 5KN9A 3FHFA 1RRSA 2NOLA 3FSPA 1MPGA 4PIIA 4E9FA 1PU7A 3N0UA 1M3QA 2JHJA 4AI5A 1RRQA 1PU6A 4B23A 1M3HA 1YQKA 3CWSA 1ORNA 1WEGA 1DIZA 1KG3A 3OGDA 2JG6A 5DPKA 1YQLA 3IH7A 1WEFA 1N3CA 1KG2A 3I0XA 3IHOA 1XQOA 1WEIA 1FN7A 1P7MA 1N39A 4OFHA 3FHGA 4EA5A 4E9GA 2XHIA 3CWUA 1KEAA 3KNTA 4OFEA 1MUNA 3CVTA 3F10A 1LWVA 3D4VA 4B22A 1KG6A 1NGNA 3F0ZA 3N5NX 3OH6A 5KN8A 1LWWA 1PVSA 2NOFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LWY A;  2YG9 A;  1KG4 A;  4YOQ A;  4E9H A;  4YPH A;  4AI4 A;  4HSB A;  4DK9 A;  2JHN A;  3CWA A;  1MUD A;  3OH9 A;  5CHZ A;  3CWT A;  1NKU A;  4EW4 A;  4YPR A;  4AIA A;  4B21 A;  1KG7 A;  4EVV A;  2NOI A;  2H56 A;  4E9E A;  2I5W A;  1ORP A;  3CVS A;  2NOH A;  3G0Q A;  3I0W A;  3KTU A;  1VRL A;  4EJZ A;  1YQM A;  1PU8 A;  1KQJ A;  3CW7 A;  4B24 A;  4EJY A;  1KO9 A;  1EBM A;  2ABK A;  1N3A A;  1XG7 A;  4UOB A;  2NOB A;  5AN4 A;  3S6I A;  2NOZ A;  2OFK A;  4EA4 A;  1MUY A;  1YQR A;  4OFA A;  4EW0 A;  1KG5 A;  2NOE A;  1LMZ A;  1XQP A;  2OFI A;  1HU0 A;  1P59 A;  4UNF A;  2YG8 A;  5KN9 A;  3FHF A;  1RRS A;  2NOL A;  3FSP A;  1MPG A;  4PII A;  4E9F A;  1PU7 A;  3N0U A;  1M3Q A;  2JHJ A;  4AI5 A;  1RRQ A;  1PU6 A;  4B23 A;  1M3H A;  1YQK A;  3CWS A;  1ORN A;  1WEG A;  1DIZ A;  1KG3 A;  3OGD A;  2JG6 A;  5DPK A;  1YQL A;  3IH7 A;  1WEF A;  1N3C A;  1KG2 A;  3I0X A;  3IHO A;  1XQO A;  1WEI A;  1FN7 A;  1P7M A;  1N39 A;  4OFH A;  3FHG A;  4EA5 A;  4E9G A;  2XHI A;  3CWU A;  1KEA A;  3KNT A;  4OFE A;  1MUN A;  3CVT A;  3F10 A;  1LWV A;  3D4V A;  4B22 A;  1KG6 A;  1NGN A;  3F0Z A;  3N5N X;  3OH6 A;  5KN8 A;  1LWW A;  1PVS A;  2NOF A; 
#chains in the Genus database with same CATH topology
 1LWY A;  4EAG A;  2HZS A;  4D7Q A;  1P5G X;  3ENO C;  4YPH A;  2FKF A;  2JHN A;  3L2W A;  4B21 A;  3OYI A;  2QLV A;  2H56 A;  1J3M A;  3KTU A;  4ZTF A;  4C7P A;  2ABK A;  2NWV A;  1XG7 A;  2NOZ A;  1KY6 A;  1TBA B;  4EA4 A;  2F7L A;  5BMN A;  2FGT A;  3OSE A;  1LMZ A;  4BE0 A;  4BDY A;  1K35 A;  2YG8 A;  3FHF A;  1TGH A;  2OOY A;  4BAC A;  2NOL A;  1MPG A;  1M5Q 1;  1PU7 A;  5BMP A;  4BDZ A;  3OYC A;  1ORN A;  1DIZ A;  4EAJ A;  3OYH A;  3OGD A;  2JG6 A;  2Y8Q A;  5HSH A;  2HL8 A;  4HJH A;  1VKL A;  4E7K A;  1KG2 A;  4QG5 A;  3OS1 A;  3L2Q A;  2H4L X;  4OFH A;  2YA3 A;  3FHG A;  3OYN A;  3D7Q A;  1JFI C;  3KNT A;  3D4V A;  1UT4 A;  3L2U A;  1RM1 A;  4WX8 A;  1TUO A;  3RPJ A;  2NOF A;  2YG9 A;  1Q9U A;  5EPC A;  1B9K A;  2IV8 A;  4DK9 A;  3CWA A;  1KYU A;  5CHZ A;  3CWT A;  1QN6 A;  5F9C A;  1ORP A;  3I0W A;  1VRL A;  1T6A A;  4EAI A;  2LAE A;  4EAK A;  3OYD A;  3VW4 A;  1KO9 A;  3OY9 A;  1EBM A;  3EIK A;  2JPI A;  3OYG A;  3KRM A;  2W04 A;  1MUY A;  1QNC A;  4EW0 A;  1NVP A;  5FRO A;  2V9J A;  1XQP A;  2QR1 A;  5KN9 A;  3OYA A;  1V5S A;  3ULX A;  3OYL A;  4EAL A;  4E9F A;  1XSZ A;  1QN4 A;  2HZM A;  2V8Q A;  1M3H A;  4B23 A;  3OS0 A;  1WEG A;  2V92 A;  3R2X C;  5KL0 A;  3S3O A;  1E42 A;  5IYD P;  2VJ0 A;  1VOL B;  1QTS A;  1WEF A;  3I0X A;  3IHO A;  2NLV A;  1WEI A;  1FN7 A;  1P7M A;  1PCZ A;  4ROE B;  4EA5 A;  1LXT A;  1KFQ A;  3OCI A;  1QNB A;  2XHI A;  4D7R A;  3TE5 A;  3L2V A;  3NNQ A;  2NVM A;  2O3O A;  2W03 A;  3F10 A;  1PCM X;  1D3U A;  1KG6 A;  1LWW A;  3OC3 C;  3OH6 A;  1PVS A;  2DKD A;  3HS8 A;  2R5X A;  2IV9 A;  2Z0F A;  1KG4 A;  1UT7 A;  4E9H A;  4AI4 A;  4HSB A;  5JN5 A;  1NKU A;  5JMV D;  4EW4 A;  4YPR A;  4ROC B;  1QN7 A;  4IKF A;  4E9E A;  2I5W A;  1U84 A;  3G0Q A;  4E7J A;  4I8O A;  3OYJ A;  1YTB A;  1YQM A;  1QN8 A;  3CW7 A;  1QN5 A;  4EJY A;  3OSM A;  2JOI A;  1W80 A;  2NOB A;  5AN4 A;  3S6I A;  5FRN A;  3ENC A;  4OFA A;  3PMG A;  5IYC P;  5FRM A;  1YTF A;  1UL7 A;  1JDY A;  1HU0 A;  1P59 A;  4UNF A;  1KYD A;  4CFF A;  2HKP A;  3DPU A;  1KY7 A;  2V75 A;  3FSP A;  4PII A;  3HS9 A;  1CDW A;  4BE2 A;  3OST A;  1M3Q A;  2JHJ A;  4AI5 A;  4BE1 A;  2D0B A;  2QRD A;  3RSM A;  1C4G A;  2OOX A;  1PU6 A;  3CWS A;  1P5D X;  1WJW A;  3IH7 A;  3OLP A;  1K2Y X;  1MP9 A;  2H5A X;  4WXA A;  1NGM A;  1C47 A;  5IYB P;  1XQO A;  3OYB A;  2YH5 A;  1PZD A;  2EHB D;  1VTL E;  4E9G A;  1EUV A;  3T4N A;  3N89 A;  1KEA A;  1VOK A;  1WQA A;  4OFE A;  1MUN A;  4E7H A;  3OYM A;  1QTP A;  1QN3 A;  3S3N A;  3PDK A;  5KN8 A;  4ZTJ A;  2Z8U A;  4Q11 A;  2FUV A;  1QNE A;  4YOQ A;  4PY5 A;  2ZFD B;  3ASM A;  4IL8 A;  1TBP A;  4WZS D;  3VN5 A;  1MUD A;  3OH9 A;  1KYF A;  3H1Z A;  2MJ7 A;  1QNA A;  4AIA A;  4EVV A;  1KG7 A;  2NOI A;  2DKA A;  4BJU A;  3CVS A;  2NOH A;  3TDH A;  4EJZ A;  4E7I A;  1PU8 A;  1KQJ A;  1PCJ X;  4B24 A;  2QRE A;  1NH2 A;  4E7L A;  3OYK A;  1N3A A;  4UOB A;  2HL9 A;  2Y8L A;  4TPS A;  2OFK A;  2D0A A;  2PWW A;  3EAY A;  3L2R A;  3BKQ X;  3C04 A;  1YQR A;  2JPS A;  1KG5 A;  2NOE A;  4B0A A;  2MZ8 A;  2OFI A;  2D0C A;  3NA5 A;  1RRS A;  2QRC A;  4NZG A;  3N0U A;  2DKC A;  1RRQ A;  1YQK A;  3LCN A;  3OYE A;  1KG3 A;  1VTO A;  3S3M A;  1QN9 A;  5DPK A;  1R4X A;  4ROD B;  1YQL A;  3I3W A;  1N3C A;  1C9B B;  2G30 A;  1N39 A;  4MRQ A;  4DUL A;  2FKM X;  3UW2 A;  3DPT A;  3CWU A;  3SNS A;  1AIS A;  1KFI A;  3OYF A;  3CVT A;  1LWV A;  3OS2 A;  1NGN A;  4B22 A;  3N5N X;  3F0Z A; 
#chains in the Genus database with same CATH homology
 1LWY A;  2YG9 A;  1KG4 A;  4YOQ A;  4E9H A;  4YPH A;  4AI4 A;  4HSB A;  4DK9 A;  2JHN A;  3CWA A;  1MUD A;  3OH9 A;  5CHZ A;  3CWT A;  1NKU A;  4EW4 A;  4YPR A;  4AIA A;  4B21 A;  1KG7 A;  4EVV A;  2NOI A;  2H56 A;  4E9E A;  2I5W A;  1ORP A;  3CVS A;  2NOH A;  3G0Q A;  3I0W A;  3KTU A;  1VRL A;  4EJZ A;  1YQM A;  1PU8 A;  1KQJ A;  3CW7 A;  4B24 A;  4EJY A;  1KO9 A;  1EBM A;  2ABK A;  1N3A A;  1XG7 A;  4UOB A;  2NOB A;  5AN4 A;  3S6I A;  2NOZ A;  2OFK A;  4EA4 A;  1MUY A;  1YQR A;  4OFA A;  4EW0 A;  1KG5 A;  2NOE A;  1LMZ A;  1XQP A;  2OFI A;  1HU0 A;  1P59 A;  4UNF A;  2YG8 A;  5KN9 A;  3FHF A;  1RRS A;  2NOL A;  3FSP A;  1MPG A;  4PII A;  4E9F A;  1PU7 A;  3N0U A;  1M3Q A;  2JHJ A;  4AI5 A;  1RRQ A;  1PU6 A;  4B23 A;  1M3H A;  1YQK A;  3CWS A;  1ORN A;  1WEG A;  1DIZ A;  1KG3 A;  3OGD A;  2JG6 A;  5DPK A;  1YQL A;  3IH7 A;  1WEF A;  1N3C A;  1KG2 A;  3I0X A;  3IHO A;  1XQO A;  1WEI A;  1FN7 A;  1P7M A;  1N39 A;  4OFH A;  3FHG A;  4EA5 A;  4E9G A;  2XHI A;  3CWU A;  1KEA A;  3KNT A;  4OFE A;  1MUN A;  3CVT A;  3F10 A;  1LWV A;  3D4V A;  4B22 A;  1KG6 A;  1NGN A;  3F0Z A;  3N5N X;  3OH6 A;  5KN8 A;  1LWW A;  1PVS A;  2NOF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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