3CWSA

Crystal structure of an alka host/guest complex 2'-fluoro-2'-deoxyinosine:thymine base pair
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Escherichia coli
molecule keywords DNA-3-methyladenine glycosylase 2
total genus 88
structure length 282
sequence length 282
chains with identical sequence B, C, D
ec nomenclature ec 3.2.2.21: DNA-3-methyladenine glycosylase II.
pdb deposition date 2008-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein
A PF06029 AlkA_N AlkA N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 3cwsA02
1.10.1670.10 Mainly Alpha Orthogonal Bundle Endonuclease Iii, domain 2 Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) 3cwsA03
3.30.310.20 Alpha Beta 2-Layer Sandwich TATA-Binding Protein DNA-3-methyladenine glycosylase AlkA, N-terminal domain 3cwsA01
4B21A 2NOIA 4EJZA 5CHZA 2NOLA 1XG7A 4AIAA 1M3QA 1LWVA 1VRLA 1RRSA 1HU0A 4B22A 2OFIA 4YOQA 1PU8A 1KG3A 2I5WA 1ORPA 1MUYA 3OGDA 4PIIA 3F10A 1N3AA 1YQRA 1WEFA 1MUDA 1N39A 1LMZA 1MPGA 4YPRA 4B24A 2XHIA 4YPHA 1KQJA 1KG6A 4OFHA 1KO9A 3IHOA 2JHJA 3IH7A 4EW4A 3I0XA 3CWUA 4EA5A 3F0ZA 1P59A 2YG9A 4AI5A 3FHFA 3OH6A 1M3HA 1NKUA 1RRQA 1LWYA 3CVSA 5DPKA 2H56A 3FHGA 1EBMA 2YG8A 3CWAA 2NOHA 1XQOA 3N5NX 2NOZA 4EVVA 3CWTA 5AN4A 4UNFA 3CWSA 3KTUA 1P7MA 4B23A 3I0WA 4E9HA 3CW7A 1YQMA 3S6IA 2JG6A 4E9EA 3OH9A 2NOFA 4E9FA 4OFAA 5KN9A 1FN7A 4HSBA 3N0UA 1YQKA 1N3CA 1PU7A 1DIZA 1WEGA 2NOEA 1YQLA 1WEIA 1NGNA 4OFEA 1LWWA 3G0QA 1KG4A 1KEAA 4EJYA 4AI4A 3FSPA 4EW0A 1KG2A 1KG7A 4UOBA 5KN8A 3D4VA 1XQPA 2JHNA 2ABKA 4E9GA 1KG5A 1MUNA 4EA4A 1PU6A 1ORNA 4DK9A 1PVSA 3KNTA 3CVTA 2NOBA 2OFKA
chains in the Genus database with same CATH superfamily
4EJZA 2D0CA 4AIAA 3SNSA 4DULA 3T4NA 3RSMA 1QNBA 4YOQA 2PWWA 1QTSA 5EPCA 3OGDA 2HL8A 5IYCP 1YQRA 1LMZA 2QR1A 4YPRA 3OYBA 2OOYA 4YPHA 1KO9A 2W04A 4E7HA 3OCIA 3OYAA 1P59A 1M3HA 1NKUA 2G30A 1LWYA 1AISA 2QREA 5DPKA 2DKDA 1KYFA 2H56A 1W80A 3TE5A 3VW4A 2YG8A 3CWAA 2NOHA 1NGMA 2NOZA 4EVVA 3CWTA 1PZDA 1P7MA 2H4LX 4B23A 4E7IA 4E9HA 3CW7A 1QNAA 3S6IA 4E7JA 4E9EA 2YA3A 4OFAA 3L2UA 4HSBA 3N0UA 2EHBD 3OSEA 1N3CA 4BJUA 2JOIA 3OYIA 2DKAA 1NGNA 1UT4A 4OFEA 2NLVA 3G0QA 1KG4A 3OYDA 4AI4A 1K35A 4EW0A 3PDKA 1MUNA 4DK9A 1E42A 1KY7A 2V8QA 3CVTA 2OFKA 4ZTJA 3OS2A 5IYBP 3R2XC 3VN5A 1XG7A 1QTPA 3ULXA 1M3QA 1LWVA 1QN7A 1RRSA 1KG3A 1ORPA 1QN6A 1MUYA 3OC3C 3TDHA 4EAGA 2F7LA 5JN5A 3OSTA 4NZGA 1WEFA 3S3OA 1NH2A 2QLVA 4B24A 4ROCB 2FUVA 2JPIA 1KG6A 2D0BA 3IH7A 3I0XA 3F0ZA 3L2VA 2YG9A 4MRQA 1MP9A 2Y8LA 1NVPA 2O3OA 5FRMA 3CVSA 2HZSA 3HS8A 5IYDP 5KL0A 1QN5A 3OYLA 2ZFDB 1QNCA 3FHGA 1VTLE 3BKQX 3KTUA 3EAYA 1KYDA 3OH9A 2VJ0A 3OYCA 4TPSA 3RPJA 1DIZA 4PY5A 1WEGA 1V5SA 3S3MA 1TBPA 4E7LA 1WEIA 2Z0FA 1KG7A 4UOBA 3DPUA 5KN8A 3D4VA 1R4XA 5FRNA 1P5GX 2ABKA 1QN3A 2FGTA 3C04A 1ORNA 4BDYA 1KY6A 2NOBA 4B21A 2NOIA 4EAJA 5CHZA 3ENCA 1QN8A 2JPSA 1VRLA 2NWVA 3OYMA 2OFIA 1PU8A 3H1ZA 3OYGA 4BE1A 1C4GA 5BMNA 4PIIA 4BACA 1N3AA 4IKFA 2V92A 1MUDA 1N39A 1QNEA 1TUOA 4OFHA 3L2QA 3NA5A 2JHJA 4EW4A 1KFQA 4WXAA 1U84A 1WQAA 4B0AA 2FKMX 4CFFA 3PMGA 4C7PA 5AN4A 3OYEA 3N89A 1KYUA 1PCMX 2NOFA 4E9FA 2MZ8A 4WZSD 1VOKA 1FN7A 2Z8UA 1XSZA 3LCNA 1YQKA 4RODB 1M5Q1 5BMPA 1YTFA 1QN9A 2LAEA 1LWWA 5HSHA 1KEAA 4EAKA 1T6AA 3OYNA 4D7QA 1KG2A 2JHNA 1KG5A 4EA4A 1CDWA 3NNQA 2IV8A 3DPTA 1PVSA 3OSMA 2V75A 1YTBA 5F9CA 3HS9A 5JMVD 4BE2A 2NOLA 1RM1A 2HL9A 3ENOC 4IL8A 1HU0A 1EUVA 1VTOA 4B22A 4D7RA 1JDYA 2I5WA 1QN4A 1PCZA 3F10A 2IV9A 4QG5A 3OYJA 1MPGA 1KFIA 3OYHA 2XHIA 4ZTFA 1KQJA 1VKLA 2HZMA 3IHOA 2Y8QA 4BDZA 4E7KA 3CWUA 1WJWA 4EA5A 4EAIA 4AI5A 3FHFA 3OH6A 2R5XA 3L2RA 3OLPA 3UW2A 1RRQA 3OY9A 4I8OA 4ROEB 1PCJX 3I3WA 1VOLB 2OOXA 1EBMA 1TBAB 1XQOA 1B9KA 3S3NA 3N5NX 1C47A 2W03A 1C9BB 4UNFA 3CWSA 3I0WA 1YQMA 2JG6A 2H5AX 1TGHA 2HKPA 5KN9A 3OYFA 2NVMA 3OS0A 1JFIC 2QRDA 1PU7A 2MJ7A 3OS1A 2QRCA 2NOEA 1J3MA 5FROA 3EIKA 1YQLA 1UL7A 2YH5A 1D3UA 2DKCA 3KRMA 2V9JA 4Q11A 4BE0A 2D0AA 3D7QA 1UT7A 4EJYA 3L2WA 4EALA 1K2YX 3FSPA 4WX8A 4HJHA 1XQPA 4E9GA 2FKFA 1PU6A 3ASMA 1Q9UA 3OYKA 3KNTA 1LXTA 1P5DX
chains in the Genus database with same CATH topology
4B21A 2NOIA 4EJZA 5CHZA 2NOLA 1XG7A 4AIAA 1M3QA 1LWVA 1VRLA 1RRSA 1HU0A 4B22A 2OFIA 4YOQA 1PU8A 1KG3A 2I5WA 1ORPA 1MUYA 3OGDA 4PIIA 3F10A 1N3AA 1YQRA 1WEFA 1MUDA 1N39A 1LMZA 1MPGA 4YPRA 4B24A 2XHIA 4YPHA 1KQJA 1KG6A 4OFHA 1KO9A 3IHOA 2JHJA 3IH7A 4EW4A 3I0XA 3CWUA 4EA5A 3F0ZA 1P59A 2YG9A 4AI5A 3FHFA 3OH6A 1M3HA 1NKUA 1RRQA 1LWYA 3CVSA 5DPKA 2H56A 3FHGA 1EBMA 2YG8A 3CWAA 2NOHA 1XQOA 3N5NX 2NOZA 4EVVA 3CWTA 5AN4A 4UNFA 3CWSA 3KTUA 1P7MA 4B23A 3I0WA 4E9HA 3CW7A 1YQMA 3S6IA 2JG6A 4E9EA 3OH9A 2NOFA 4E9FA 4OFAA 5KN9A 1FN7A 4HSBA 3N0UA 1YQKA 1N3CA 1PU7A 1DIZA 1WEGA 2NOEA 1YQLA 1WEIA 1NGNA 4OFEA 1LWWA 3G0QA 1KG4A 1KEAA 4EJYA 4AI4A 3FSPA 4EW0A 1KG2A 1KG7A 4UOBA 5KN8A 3D4VA 1XQPA 2JHNA 2ABKA 4E9GA 1KG5A 1MUNA 4EA4A 1PU6A 1ORNA 4DK9A 1PVSA 3KNTA 3CVTA 2NOBA 2OFKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4B21 A;  2NOI A;  4EJZ A;  5CHZ A;  2NOL A;  1XG7 A;  4AIA A;  1M3Q A;  1LWV A;  1VRL A;  1RRS A;  1HU0 A;  4B22 A;  2OFI A;  4YOQ A;  1PU8 A;  1KG3 A;  2I5W A;  1ORP A;  1MUY A;  3OGD A;  4PII A;  3F10 A;  1N3A A;  1YQR A;  1WEF A;  1MUD A;  1N39 A;  1LMZ A;  1MPG A;  4YPR A;  4B24 A;  2XHI A;  4YPH A;  1KQJ A;  1KG6 A;  4OFH A;  1KO9 A;  3IHO A;  2JHJ A;  3IH7 A;  4EW4 A;  3I0X A;  3CWU A;  4EA5 A;  3F0Z A;  1P59 A;  2YG9 A;  4AI5 A;  3FHF A;  3OH6 A;  1M3H A;  1NKU A;  1RRQ A;  1LWY A;  3CVS A;  5DPK A;  2H56 A;  3FHG A;  1EBM A;  2YG8 A;  3CWA A;  2NOH A;  1XQO A;  3N5N X;  2NOZ A;  4EVV A;  3CWT A;  5AN4 A;  4UNF A;  3CWS A;  3KTU A;  1P7M A;  4B23 A;  3I0W A;  4E9H A;  3CW7 A;  1YQM A;  3S6I A;  2JG6 A;  4E9E A;  3OH9 A;  2NOF A;  4E9F A;  4OFA A;  5KN9 A;  1FN7 A;  4HSB A;  3N0U A;  1YQK A;  1N3C A;  1PU7 A;  1DIZ A;  1WEG A;  2NOE A;  1YQL A;  1WEI A;  1NGN A;  4OFE A;  1LWW A;  3G0Q A;  1KG4 A;  1KEA A;  4EJY A;  4AI4 A;  3FSP A;  4EW0 A;  1KG2 A;  1KG7 A;  4UOB A;  5KN8 A;  3D4V A;  1XQP A;  2JHN A;  2ABK A;  4E9G A;  1KG5 A;  1MUN A;  4EA4 A;  1PU6 A;  1ORN A;  4DK9 A;  1PVS A;  3KNT A;  3CVT A;  2NOB A;  2OFK A; 
#chains in the Genus database with same CATH topology
 4EJZ A;  2D0C A;  4AIA A;  3SNS A;  4DUL A;  3T4N A;  3RSM A;  1QNB A;  4YOQ A;  2PWW A;  1QTS A;  5EPC A;  3OGD A;  2HL8 A;  5IYC P;  1YQR A;  1LMZ A;  2QR1 A;  4YPR A;  3OYB A;  2OOY A;  4YPH A;  1KO9 A;  2W04 A;  4E7H A;  3OCI A;  3OYA A;  1P59 A;  1M3H A;  1NKU A;  2G30 A;  1LWY A;  1AIS A;  2QRE A;  5DPK A;  2DKD A;  1KYF A;  2H56 A;  1W80 A;  3TE5 A;  3VW4 A;  2YG8 A;  3CWA A;  2NOH A;  1NGM A;  2NOZ A;  4EVV A;  3CWT A;  1PZD A;  1P7M A;  2H4L X;  4B23 A;  4E7I A;  4E9H A;  3CW7 A;  1QNA A;  3S6I A;  4E7J A;  4E9E A;  2YA3 A;  4OFA A;  3L2U A;  4HSB A;  3N0U A;  2EHB D;  3OSE A;  1N3C A;  4BJU A;  2JOI A;  3OYI A;  2DKA A;  1NGN A;  1UT4 A;  4OFE A;  2NLV A;  3G0Q A;  1KG4 A;  3OYD A;  4AI4 A;  1K35 A;  4EW0 A;  3PDK A;  1MUN A;  4DK9 A;  1E42 A;  1KY7 A;  2V8Q A;  3CVT A;  2OFK A;  4ZTJ A;  3OS2 A;  5IYB P;  3R2X C;  3VN5 A;  1XG7 A;  1QTP A;  3ULX A;  1M3Q A;  1LWV A;  1QN7 A;  1RRS A;  1KG3 A;  1ORP A;  1QN6 A;  1MUY A;  3OC3 C;  3TDH A;  4EAG A;  2F7L A;  5JN5 A;  3OST A;  4NZG A;  1WEF A;  3S3O A;  1NH2 A;  2QLV A;  4B24 A;  4ROC B;  2FUV A;  2JPI A;  1KG6 A;  2D0B A;  3IH7 A;  3I0X A;  3F0Z A;  3L2V A;  2YG9 A;  4MRQ A;  1MP9 A;  2Y8L A;  1NVP A;  2O3O A;  5FRM A;  3CVS A;  2HZS A;  3HS8 A;  5IYD P;  5KL0 A;  1QN5 A;  3OYL A;  2ZFD B;  1QNC A;  3FHG A;  1VTL E;  3BKQ X;  3KTU A;  3EAY A;  1KYD A;  3OH9 A;  2VJ0 A;  3OYC A;  4TPS A;  3RPJ A;  1DIZ A;  4PY5 A;  1WEG A;  1V5S A;  3S3M A;  1TBP A;  4E7L A;  1WEI A;  2Z0F A;  1KG7 A;  4UOB A;  3DPU A;  5KN8 A;  3D4V A;  1R4X A;  5FRN A;  1P5G X;  2ABK A;  1QN3 A;  2FGT A;  3C04 A;  1ORN A;  4BDY A;  1KY6 A;  2NOB A;  4B21 A;  2NOI A;  4EAJ A;  5CHZ A;  3ENC A;  1QN8 A;  2JPS A;  1VRL A;  2NWV A;  3OYM A;  2OFI A;  1PU8 A;  3H1Z A;  3OYG A;  4BE1 A;  1C4G A;  5BMN A;  4PII A;  4BAC A;  1N3A A;  4IKF A;  2V92 A;  1MUD A;  1N39 A;  1QNE A;  1TUO A;  4OFH A;  3L2Q A;  3NA5 A;  2JHJ A;  4EW4 A;  1KFQ A;  4WXA A;  1U84 A;  1WQA A;  4B0A A;  2FKM X;  4CFF A;  3PMG A;  4C7P A;  5AN4 A;  3OYE A;  3N89 A;  1KYU A;  1PCM X;  2NOF A;  4E9F A;  2MZ8 A;  4WZS D;  1VOK A;  1FN7 A;  2Z8U A;  1XSZ A;  3LCN A;  1YQK A;  4ROD B;  1M5Q 1;  5BMP A;  1YTF A;  1QN9 A;  2LAE A;  1LWW A;  5HSH A;  1KEA A;  4EAK A;  1T6A A;  3OYN A;  4D7Q A;  1KG2 A;  2JHN A;  1KG5 A;  4EA4 A;  1CDW A;  3NNQ A;  2IV8 A;  3DPT A;  1PVS A;  3OSM A;  2V75 A;  1YTB A;  5F9C A;  3HS9 A;  5JMV D;  4BE2 A;  2NOL A;  1RM1 A;  2HL9 A;  3ENO C;  4IL8 A;  1HU0 A;  1EUV A;  1VTO A;  4B22 A;  4D7R A;  1JDY A;  2I5W A;  1QN4 A;  1PCZ A;  3F10 A;  2IV9 A;  4QG5 A;  3OYJ A;  1MPG A;  1KFI A;  3OYH A;  2XHI A;  4ZTF A;  1KQJ A;  1VKL A;  2HZM A;  3IHO A;  2Y8Q A;  4BDZ A;  4E7K A;  3CWU A;  1WJW A;  4EA5 A;  4EAI A;  4AI5 A;  3FHF A;  3OH6 A;  2R5X A;  3L2R A;  3OLP A;  3UW2 A;  1RRQ A;  3OY9 A;  4I8O A;  4ROE B;  1PCJ X;  3I3W A;  1VOL B;  2OOX A;  1EBM A;  1TBA B;  1XQO A;  1B9K A;  3S3N A;  3N5N X;  1C47 A;  2W03 A;  1C9B B;  4UNF A;  3CWS A;  3I0W A;  1YQM A;  2JG6 A;  2H5A X;  1TGH A;  2HKP A;  5KN9 A;  3OYF A;  2NVM A;  3OS0 A;  1JFI C;  2QRD A;  1PU7 A;  2MJ7 A;  3OS1 A;  2QRC A;  2NOE A;  1J3M A;  5FRO A;  3EIK A;  1YQL A;  1UL7 A;  2YH5 A;  1D3U A;  2DKC A;  3KRM A;  2V9J A;  4Q11 A;  4BE0 A;  2D0A A;  3D7Q A;  1UT7 A;  4EJY A;  3L2W A;  4EAL A;  1K2Y X;  3FSP A;  4WX8 A;  4HJH A;  1XQP A;  4E9G A;  2FKF A;  1PU6 A;  3ASM A;  1Q9U A;  3OYK A;  3KNT A;  1LXT A;  1P5D X; 
#chains in the Genus database with same CATH homology
 4B21 A;  2NOI A;  4EJZ A;  5CHZ A;  2NOL A;  1XG7 A;  4AIA A;  1M3Q A;  1LWV A;  1VRL A;  1RRS A;  1HU0 A;  4B22 A;  2OFI A;  4YOQ A;  1PU8 A;  1KG3 A;  2I5W A;  1ORP A;  1MUY A;  3OGD A;  4PII A;  3F10 A;  1N3A A;  1YQR A;  1WEF A;  1MUD A;  1N39 A;  1LMZ A;  1MPG A;  4YPR A;  4B24 A;  2XHI A;  4YPH A;  1KQJ A;  1KG6 A;  4OFH A;  1KO9 A;  3IHO A;  2JHJ A;  3IH7 A;  4EW4 A;  3I0X A;  3CWU A;  4EA5 A;  3F0Z A;  1P59 A;  2YG9 A;  4AI5 A;  3FHF A;  3OH6 A;  1M3H A;  1NKU A;  1RRQ A;  1LWY A;  3CVS A;  5DPK A;  2H56 A;  3FHG A;  1EBM A;  2YG8 A;  3CWA A;  2NOH A;  1XQO A;  3N5N X;  2NOZ A;  4EVV A;  3CWT A;  5AN4 A;  4UNF A;  3CWS A;  3KTU A;  1P7M A;  4B23 A;  3I0W A;  4E9H A;  3CW7 A;  1YQM A;  3S6I A;  2JG6 A;  4E9E A;  3OH9 A;  2NOF A;  4E9F A;  4OFA A;  5KN9 A;  1FN7 A;  4HSB A;  3N0U A;  1YQK A;  1N3C A;  1PU7 A;  1DIZ A;  1WEG A;  2NOE A;  1YQL A;  1WEI A;  1NGN A;  4OFE A;  1LWW A;  3G0Q A;  1KG4 A;  1KEA A;  4EJY A;  4AI4 A;  3FSP A;  4EW0 A;  1KG2 A;  1KG7 A;  4UOB A;  5KN8 A;  3D4V A;  1XQP A;  2JHN A;  2ABK A;  4E9G A;  1KG5 A;  1MUN A;  4EA4 A;  1PU6 A;  1ORN A;  4DK9 A;  1PVS A;  3KNT A;  3CVT A;  2NOB A;  2OFK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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