3CWSA

Crystal structure of an alka host/guest complex 2'-fluoro-2'-deoxyinosine:thymine base pair
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Escherichia coli
molecule keywords DNA-3-methyladenine glycosylase 2
total genus 88
structure length 282
sequence length 282
chains with identical sequence B, C, D
ec nomenclature ec 3.2.2.21: DNA-3-methyladenine glycosylase II.
pdb deposition date 2008-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein
A PF06029 AlkA_N AlkA N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 3cwsA02
1.10.1670.10 Mainly Alpha Orthogonal Bundle Endonuclease Iii, domain 2 Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) 3cwsA03
3.30.310.20 Alpha Beta 2-Layer Sandwich TATA-Binding Protein DNA-3-methyladenine glycosylase AlkA, N-terminal domain 3cwsA01
1KG7A 3KNTA 2NOEA 4OFEA 5CHZA 4B21A 1ORNA 1PVSA 5AN4A 4OFHA 1NGNA 1RRSA 1WEIA 1LWWA 1RRQA 2OFIA 3FHGA 1KQJA 1MUYA 1NKUA 1KG5A 1KO9A 4HSBA 2ABKA 2NOZA 2OFKA 3F0ZA 1LWVA 3CVSA 4AIAA 1VRLA 2NOIA 1MPGA 1KG2A 1KG4A 1MUDA 3F10A 2XHIA 1N3AA 4UOBA 1YQRA 3CWTA 4PIIA 1XG7A 4YPRA 4B23A 2YG8A 3FSPA 3FHFA 3G0QA 3IH7A 5KN8A 3KTUA 3CWSA 4B22A 1WEGA 4UNFA 1HU0A 4EJYA 1YQMA 1P7MA 2JG6A 3D4VA 1PU7A 4YPHA 3OH9A 4EA4A 1KG6A 4E9EA 4EVVA 4E9FA 3CW7A 3N0UA 4DK9A 2NOLA 5KN9A 4B24A 1P59A 1PU8A 4EW4A 1XQOA 3OGDA 1FN7A 1DIZA 2NOHA 3CWUA 4E9HA 1YQLA 2NOBA 1MUNA 3IHOA 5DPKA 1KG3A 4E9GA 1N3CA 3I0XA 1ORPA 1LMZA 1KEAA 3OH6A 1M3HA 2I5WA 2YG9A 3S6IA 4EW0A 4YOQA 1YQKA 4OFAA 3CVTA 2JHJA 2JHNA 4AI4A 3I0WA 4AI5A 1WEFA 1N39A 1EBMA 1PU6A 3N5NX 1M3QA 4EA5A 3CWAA 2NOFA 2H56A 1XQPA 4EJZA 1LWYA
chains in the Genus database with same CATH superfamily
1KG7A 3UW2A 4B21A 1PVSA 3I3WA 1NGNA 1QNEA 1WEIA 4E7HA 2OFIA 4B0AA 2ABKA 2NOZA 3F0ZA 4AIAA 2NOIA 4NZGA 1MPGA 2Y8QA 3BKQX 1KG4A 4WX8A 4I8OA 1J3MA 1LXTA 1N3AA 2VJ0A 3CWTA 1PZDA 3OYMA 2YG8A 4D7QA 4EAIA 3OYBA 5KN8A 4EJYA 3OYAA 2R5XA 1KYDA 4E9EA 3OYIA 3OYGA 4EVVA 1XSZA 3L2VA 3EAYA 1VTLE 4MRQA 2HL8A 3OY9A 4EAGA 2NWVA 2MJ7A 4B24A 1XQOA 1U84A 1FN7A 4BE2A 1QNCA 3PDKA 3IHOA 1VKLA 3OYFA 1KG3A 2W03A 3D7QA 3RSMA 1TGHA 1ORPA 1Q9UA 1CDWA 2ZFDB 1KYFA 1YQKA 1P5GX 1QN5A 3S3OA 2QRCA 4AI4A 4BDZA 4E7LA 1QNBA 1KYUA 3I0WA 1WEFA 1EBMA 2QREA 3TE5A 1YTBA 4C7PA 3OCIA 4Q11A 2V9JA 1LWYA 3L2WA 1KFIA 3OLPA 1RRSA 2LAEA 1RRQA 1NKUA 1KG5A 4HSBA 2Z0FA 1C47A 2H4LX 3OYDA 1WJWA 2JPIA 3CVSA 2JPSA 3OC3C 4TPSA 5BMNA 2XHIA 4UOBA 4ZTJA 1YQRA 2DKAA 1XG7A 2FKFA 3VN5A 2JOIA 1D3UA 4E7JA 3IH7A 3KTUA 2FGTA 2V92A 1WEGA 4UNFA 3OYHA 1HU0A 4BE0A 1P7MA 3LCNA 3L2QA 3D4VA 3S3NA 4YPHA 1KG6A 3H1ZA 2PWWA 4DK9A 3OYKA 2DKCA 2NOLA 1E42A 2EHBD 4EAJA 1NVPA 2OOXA 2D0AA 2MZ8A 1PU8A 1P5DX 1PCMX 3NA5A 3CWUA 1KFQA 2NOBA 4BACA 2FKMX 5DPKA 4BE1A 1MP9A 3I0XA 1QTSA 3SNSA 1LMZA 5FRNA 2G30A 1KEAA 1M3HA 3S6IA 2QRDA 4YOQA 2W04A 3OYLA 4AI5A 1N39A 4E7KA 4EAKA 1JFIC 1R4XA 4E7IA 1QTPA 1VTOA 2NOEA 3OYJA 4ROCB 3OS1A 1ORNA 5IYDP 2OOYA 1LWWA 1K2YX 3OSMA 1QN8A 1KQJA 1MUYA 3ENCA 1NH2A 1KO9A 3R2XC 2OFKA 3DPTA 1LWVA 5JN5A 1KG2A 3OS2A 1RM1A 3F10A 1QN7A 1UT4A 5IYBP 2QR1A 5FROA 4B23A 3L2RA 4WXAA 3FHFA 3OSEA 3CWSA 4RODB 1QN4A 1C9BB 4DULA 4EA4A 1YTFA 3PMGA 3CW7A 3N0UA 4PY5A 5HSHA 1PCJX 1T6AA 1UT7A 1TBAB 2FUVA 2NOHA 5BMPA 3T4NA 1K35A 3ULXA 1EUVA 1QN9A 5FRMA 3C04A 1TBPA 4E9GA 1UL7A 2V75A 1WQAA 2IV8A 2HZMA 3OH6A 2I5WA 2YG9A 4EW0A 1M5Q1 4EALA 1AISA 2JHJA 2JHNA 3DPUA 2Z8UA 2IV9A 2NVMA 3OS0A 2DKDA 1PU6A 1VOLB 1M3QA 2Y8LA 1XQPA 4EJZA 3L2UA 5JMVD 3KNTA 1W80A 1TUOA 4OFEA 5CHZA 1QN6A 2HKPA 5AN4A 5IYCP 1KY7A 4OFHA 4HJHA 4IL8A 3FHGA 3VW4A 3HS9A 1JDYA 4IKFA 1VRLA 1MUDA 3ENOC 1QNAA 2NLVA 1VOKA 5F9CA 4PIIA 1KY6A 4BDYA 2F7LA 3S3MA 4YPRA 2HL9A 4WZSD 3FSPA 5KL0A 3G0QA 2D0BA 2QLVA 3ASMA 1C4GA 4B22A 3OYNA 1YQMA 1PCZA 2JG6A 1PU7A 3OH9A 2O3OA 3EIKA 5EPCA 4E9FA 3NNQA 3RPJA 1NGMA 5KN9A 2HZSA 3N89A 3OYCA 3OSTA 1P59A 4EW4A 3OGDA 3HS8A 1QN3A 1DIZA 4D7RA 4E9HA 1YQLA 1MUNA 4BJUA 1V5SA 1B9KA 2V8QA 1N3CA 3KRMA 4OFAA 3CVTA 2YA3A 2D0CA 2H5AX 4CFFA 4ROEB 3OYEA 4QG5A 3N5NX 2YH5A 4EA5A 4ZTFA 3CWAA 2NOFA 2H56A 3TDHA
chains in the Genus database with same CATH topology
1KG7A 3KNTA 2NOEA 4OFEA 5CHZA 4B21A 1ORNA 1PVSA 5AN4A 4OFHA 1NGNA 1RRSA 1WEIA 1LWWA 1RRQA 2OFIA 3FHGA 1KQJA 1MUYA 1NKUA 1KG5A 1KO9A 4HSBA 2ABKA 2NOZA 2OFKA 3F0ZA 1LWVA 3CVSA 4AIAA 1VRLA 2NOIA 1MPGA 1KG2A 1KG4A 1MUDA 3F10A 2XHIA 1N3AA 4UOBA 1YQRA 3CWTA 4PIIA 1XG7A 4YPRA 4B23A 2YG8A 3FSPA 3FHFA 3G0QA 3IH7A 5KN8A 3KTUA 3CWSA 4B22A 1WEGA 4UNFA 1HU0A 4EJYA 1YQMA 1P7MA 2JG6A 3D4VA 1PU7A 4YPHA 3OH9A 4EA4A 1KG6A 4E9EA 4EVVA 4E9FA 3CW7A 3N0UA 4DK9A 2NOLA 5KN9A 4B24A 1P59A 1PU8A 4EW4A 1XQOA 3OGDA 1FN7A 1DIZA 2NOHA 3CWUA 4E9HA 1YQLA 2NOBA 1MUNA 3IHOA 5DPKA 1KG3A 4E9GA 1N3CA 3I0XA 1ORPA 1LMZA 1KEAA 3OH6A 1M3HA 2I5WA 2YG9A 3S6IA 4EW0A 4YOQA 1YQKA 4OFAA 3CVTA 2JHJA 2JHNA 4AI4A 3I0WA 4AI5A 1WEFA 1N39A 1EBMA 1PU6A 3N5NX 1M3QA 4EA5A 3CWAA 2NOFA 2H56A 1XQPA 4EJZA 1LWYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KG7 A;  3KNT A;  2NOE A;  4OFE A;  5CHZ A;  4B21 A;  1ORN A;  1PVS A;  5AN4 A;  4OFH A;  1NGN A;  1RRS A;  1WEI A;  1LWW A;  1RRQ A;  2OFI A;  3FHG A;  1KQJ A;  1MUY A;  1NKU A;  1KG5 A;  1KO9 A;  4HSB A;  2ABK A;  2NOZ A;  2OFK A;  3F0Z A;  1LWV A;  3CVS A;  4AIA A;  1VRL A;  2NOI A;  1MPG A;  1KG2 A;  1KG4 A;  1MUD A;  3F10 A;  2XHI A;  1N3A A;  4UOB A;  1YQR A;  3CWT A;  4PII A;  1XG7 A;  4YPR A;  4B23 A;  2YG8 A;  3FSP A;  3FHF A;  3G0Q A;  3IH7 A;  5KN8 A;  3KTU A;  3CWS A;  4B22 A;  1WEG A;  4UNF A;  1HU0 A;  4EJY A;  1YQM A;  1P7M A;  2JG6 A;  3D4V A;  1PU7 A;  4YPH A;  3OH9 A;  4EA4 A;  1KG6 A;  4E9E A;  4EVV A;  4E9F A;  3CW7 A;  3N0U A;  4DK9 A;  2NOL A;  5KN9 A;  4B24 A;  1P59 A;  1PU8 A;  4EW4 A;  1XQO A;  3OGD A;  1FN7 A;  1DIZ A;  2NOH A;  3CWU A;  4E9H A;  1YQL A;  2NOB A;  1MUN A;  3IHO A;  5DPK A;  1KG3 A;  4E9G A;  1N3C A;  3I0X A;  1ORP A;  1LMZ A;  1KEA A;  3OH6 A;  1M3H A;  2I5W A;  2YG9 A;  3S6I A;  4EW0 A;  4YOQ A;  1YQK A;  4OFA A;  3CVT A;  2JHJ A;  2JHN A;  4AI4 A;  3I0W A;  4AI5 A;  1WEF A;  1N39 A;  1EBM A;  1PU6 A;  3N5N X;  1M3Q A;  4EA5 A;  3CWA A;  2NOF A;  2H56 A;  1XQP A;  4EJZ A;  1LWY A; 
#chains in the Genus database with same CATH topology
 1KG7 A;  3UW2 A;  4B21 A;  1PVS A;  3I3W A;  1NGN A;  1QNE A;  1WEI A;  4E7H A;  2OFI A;  4B0A A;  2ABK A;  2NOZ A;  3F0Z A;  4AIA A;  2NOI A;  4NZG A;  1MPG A;  2Y8Q A;  3BKQ X;  1KG4 A;  4WX8 A;  4I8O A;  1J3M A;  1LXT A;  1N3A A;  2VJ0 A;  3CWT A;  1PZD A;  3OYM A;  2YG8 A;  4D7Q A;  4EAI A;  3OYB A;  5KN8 A;  4EJY A;  3OYA A;  2R5X A;  1KYD A;  4E9E A;  3OYI A;  3OYG A;  4EVV A;  1XSZ A;  3L2V A;  3EAY A;  1VTL E;  4MRQ A;  2HL8 A;  3OY9 A;  4EAG A;  2NWV A;  2MJ7 A;  4B24 A;  1XQO A;  1U84 A;  1FN7 A;  4BE2 A;  1QNC A;  3PDK A;  3IHO A;  1VKL A;  3OYF A;  1KG3 A;  2W03 A;  3D7Q A;  3RSM A;  1TGH A;  1ORP A;  1Q9U A;  1CDW A;  2ZFD B;  1KYF A;  1YQK A;  1P5G X;  1QN5 A;  3S3O A;  2QRC A;  4AI4 A;  4BDZ A;  4E7L A;  1QNB A;  1KYU A;  3I0W A;  1WEF A;  1EBM A;  2QRE A;  3TE5 A;  1YTB A;  4C7P A;  3OCI A;  4Q11 A;  2V9J A;  1LWY A;  3L2W A;  1KFI A;  3OLP A;  1RRS A;  2LAE A;  1RRQ A;  1NKU A;  1KG5 A;  4HSB A;  2Z0F A;  1C47 A;  2H4L X;  3OYD A;  1WJW A;  2JPI A;  3CVS A;  2JPS A;  3OC3 C;  4TPS A;  5BMN A;  2XHI A;  4UOB A;  4ZTJ A;  1YQR A;  2DKA A;  1XG7 A;  2FKF A;  3VN5 A;  2JOI A;  1D3U A;  4E7J A;  3IH7 A;  3KTU A;  2FGT A;  2V92 A;  1WEG A;  4UNF A;  3OYH A;  1HU0 A;  4BE0 A;  1P7M A;  3LCN A;  3L2Q A;  3D4V A;  3S3N A;  4YPH A;  1KG6 A;  3H1Z A;  2PWW A;  4DK9 A;  3OYK A;  2DKC A;  2NOL A;  1E42 A;  2EHB D;  4EAJ A;  1NVP A;  2OOX A;  2D0A A;  2MZ8 A;  1PU8 A;  1P5D X;  1PCM X;  3NA5 A;  3CWU A;  1KFQ A;  2NOB A;  4BAC A;  2FKM X;  5DPK A;  4BE1 A;  1MP9 A;  3I0X A;  1QTS A;  3SNS A;  1LMZ A;  5FRN A;  2G30 A;  1KEA A;  1M3H A;  3S6I A;  2QRD A;  4YOQ A;  2W04 A;  3OYL A;  4AI5 A;  1N39 A;  4E7K A;  4EAK A;  1JFI C;  1R4X A;  4E7I A;  1QTP A;  1VTO A;  2NOE A;  3OYJ A;  4ROC B;  3OS1 A;  1ORN A;  5IYD P;  2OOY A;  1LWW A;  1K2Y X;  3OSM A;  1QN8 A;  1KQJ A;  1MUY A;  3ENC A;  1NH2 A;  1KO9 A;  3R2X C;  2OFK A;  3DPT A;  1LWV A;  5JN5 A;  1KG2 A;  3OS2 A;  1RM1 A;  3F10 A;  1QN7 A;  1UT4 A;  5IYB P;  2QR1 A;  5FRO A;  4B23 A;  3L2R A;  4WXA A;  3FHF A;  3OSE A;  3CWS A;  4ROD B;  1QN4 A;  1C9B B;  4DUL A;  4EA4 A;  1YTF A;  3PMG A;  3CW7 A;  3N0U A;  4PY5 A;  5HSH A;  1PCJ X;  1T6A A;  1UT7 A;  1TBA B;  2FUV A;  2NOH A;  5BMP A;  3T4N A;  1K35 A;  3ULX A;  1EUV A;  1QN9 A;  5FRM A;  3C04 A;  1TBP A;  4E9G A;  1UL7 A;  2V75 A;  1WQA A;  2IV8 A;  2HZM A;  3OH6 A;  2I5W A;  2YG9 A;  4EW0 A;  1M5Q 1;  4EAL A;  1AIS A;  2JHJ A;  2JHN A;  3DPU A;  2Z8U A;  2IV9 A;  2NVM A;  3OS0 A;  2DKD A;  1PU6 A;  1VOL B;  1M3Q A;  2Y8L A;  1XQP A;  4EJZ A;  3L2U A;  5JMV D;  3KNT A;  1W80 A;  1TUO A;  4OFE A;  5CHZ A;  1QN6 A;  2HKP A;  5AN4 A;  5IYC P;  1KY7 A;  4OFH A;  4HJH A;  4IL8 A;  3FHG A;  3VW4 A;  3HS9 A;  1JDY A;  4IKF A;  1VRL A;  1MUD A;  3ENO C;  1QNA A;  2NLV A;  1VOK A;  5F9C A;  4PII A;  1KY6 A;  4BDY A;  2F7L A;  3S3M A;  4YPR A;  2HL9 A;  4WZS D;  3FSP A;  5KL0 A;  3G0Q A;  2D0B A;  2QLV A;  3ASM A;  1C4G A;  4B22 A;  3OYN A;  1YQM A;  1PCZ A;  2JG6 A;  1PU7 A;  3OH9 A;  2O3O A;  3EIK A;  5EPC A;  4E9F A;  3NNQ A;  3RPJ A;  1NGM A;  5KN9 A;  2HZS A;  3N89 A;  3OYC A;  3OST A;  1P59 A;  4EW4 A;  3OGD A;  3HS8 A;  1QN3 A;  1DIZ A;  4D7R A;  4E9H A;  1YQL A;  1MUN A;  4BJU A;  1V5S A;  1B9K A;  2V8Q A;  1N3C A;  3KRM A;  4OFA A;  3CVT A;  2YA3 A;  2D0C A;  2H5A X;  4CFF A;  4ROE B;  3OYE A;  4QG5 A;  3N5N X;  2YH5 A;  4EA5 A;  4ZTF A;  3CWA A;  2NOF A;  2H56 A;  3TDH A; 
#chains in the Genus database with same CATH homology
 1KG7 A;  3KNT A;  2NOE A;  4OFE A;  5CHZ A;  4B21 A;  1ORN A;  1PVS A;  5AN4 A;  4OFH A;  1NGN A;  1RRS A;  1WEI A;  1LWW A;  1RRQ A;  2OFI A;  3FHG A;  1KQJ A;  1MUY A;  1NKU A;  1KG5 A;  1KO9 A;  4HSB A;  2ABK A;  2NOZ A;  2OFK A;  3F0Z A;  1LWV A;  3CVS A;  4AIA A;  1VRL A;  2NOI A;  1MPG A;  1KG2 A;  1KG4 A;  1MUD A;  3F10 A;  2XHI A;  1N3A A;  4UOB A;  1YQR A;  3CWT A;  4PII A;  1XG7 A;  4YPR A;  4B23 A;  2YG8 A;  3FSP A;  3FHF A;  3G0Q A;  3IH7 A;  5KN8 A;  3KTU A;  3CWS A;  4B22 A;  1WEG A;  4UNF A;  1HU0 A;  4EJY A;  1YQM A;  1P7M A;  2JG6 A;  3D4V A;  1PU7 A;  4YPH A;  3OH9 A;  4EA4 A;  1KG6 A;  4E9E A;  4EVV A;  4E9F A;  3CW7 A;  3N0U A;  4DK9 A;  2NOL A;  5KN9 A;  4B24 A;  1P59 A;  1PU8 A;  4EW4 A;  1XQO A;  3OGD A;  1FN7 A;  1DIZ A;  2NOH A;  3CWU A;  4E9H A;  1YQL A;  2NOB A;  1MUN A;  3IHO A;  5DPK A;  1KG3 A;  4E9G A;  1N3C A;  3I0X A;  1ORP A;  1LMZ A;  1KEA A;  3OH6 A;  1M3H A;  2I5W A;  2YG9 A;  3S6I A;  4EW0 A;  4YOQ A;  1YQK A;  4OFA A;  3CVT A;  2JHJ A;  2JHN A;  4AI4 A;  3I0W A;  4AI5 A;  1WEF A;  1N39 A;  1EBM A;  1PU6 A;  3N5N X;  1M3Q A;  4EA5 A;  3CWA A;  2NOF A;  2H56 A;  1XQP A;  4EJZ A;  1LWY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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