2ERHA

Crystal structure of the e7_g/im7_g complex; a designed interface between the colicin e7 dnase and the im7 immunity protein
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
87
structure length
87
Chain Sequence
MELKNSISDYTEAEFVQLLKEIEKENVAATDDVLYVLLEHFVKITEHPDGQDLIYYPSDNRDDSPEGIVKEIKEWRAANGKPGFKQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Escherichia coli
molecule keywords Colicin E7 immunity protein
total genus 34
structure length 87
sequence length 87
ec nomenclature
pdb deposition date 2005-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01320 Colicin_Pyocin Colicin immunity protein / pyocin immunity protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1200.20 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A Colicin E immunity protein 2erhA00
3U43A 1BXIA 1IMPA 2GYKA 2GZIA 1GXHA 3GKLC 4UHPB 2K5XA 2VLOA 2K0DX 2GZGA 1ZNVA 2JB0A 3GJNA 2JBGA 1FR2A 2NO8A 1E0HA 2VLQA 2WPTA 1UNKA 2GZJA 1CEIA 2VLNA 2GZEA 2GZFA 2VLPA 7CEIA 1IMQA 1MZ8A 1GXGA 1UJZA 5EW5E 4F37A 2ERHA 4QKOA 1AYIA 2JAZA 1EMVA
chains in the Genus database with same CATH superfamily
2M8PA 4QNBA 1NJIQ 3GKLC 3B5IA 3I55P 2CNRA 2XZ1C 3P05A 4GR2A 1ZNVA 4PWVB 2ONTA 1DNYA 1K8AQ 1OR5A 2NO8A 2XT1A 4U0EA 1HY8A 3OW2O 1QVGO 4H2WC 3VRLC 2LTEA 1MZ8A 3G1GA 2L4BA 3G6EP 1IMPA 2OTJP 5CZDB 2KG9A 3GZLA 3LMOA 3CCLP 5EJDA 5I4TG 2GDWA 3DS5A 2PY8A 2X2BA 1K30A 2LIUA 2K92A 2EG5A 2FQ0A 3CE7A 4U0BA 2LL8A 3CMAP 2KOPA 3DS3A 1N8RQ 2Z44A 1K9MQ 1YIJP 4BPGA 1Q81Q 2Z45A 2BHVA 5HGMA 1EIAA 2DNWA 1RO0A 1YJ9P 1M6NA 4U0AA 2JB0A 1VHNA 3GZMA 1L0IA 2K94A 5EW5E 2JQ4A 2KOSA 1EMVA 2JGPA 1AUMA 2K0XA 3E2DA 2CQ8A 3RG2A 2N5IA 2K0DX 2QA4P 1VQ4P 1VQ8P 2LIWA 1QRJA 1YHQP 3G1IA 3DPHA 1M90Q 3DS0A 1S72P 3B4QA 4H2YC 5JPAA 4CA3A 1A43A 5KP7B 3HZQA 2BUOA 2K0YA 2AVAA 4XROA 1IMQA 1UJZA 3CC4P 1E6JP 2L22A 2ERHA 4QKOA 2JAZA 2MVVA 4IPYA 1M1KQ 2VLOA 3CPWO 4BPHA 2MR8A 1DV5A 2E1MA 2KODA 1A8OA 4U0CA 2KGAA 1CEIA 1YITP 1ZMBA 4H2XC 4DG9A 1KQSO 1JJ2O 3U43A 1BXIA 2KOQA 2GZIA 1GXHA 2EHTA 1KC8Q 2XV6A 1Q82Q 1VQMP 2QEXP 2KOOA 2KG8A 4XFZA 1KLPA 5HGOA 1M74A 1QVFO 1GPJA 2KGEA 2OTLP 1ACPA 1VKUA 3CCEP 5F2KA 1VQNP 3G29A 2L6EA 2LMLA 2KGDA 5KP8B 4COPA 2M5RA 2PNGA 2JBGA 2XXMA 2LOLA 1FR2A 2N98A 2P9XA 1E0HA 3NY7B 2JU2A 3CC2P 3HYBA 3CMEP 1HQBA 1Z6MA 4U0FA 3G21A 2JYGA 5F2NA 2GDYA 3CCQP 3CCSP 1X3OA 2DGYA 2CGQA 1Q7YQ 2FVEA 3G28A 3WBHA 2VLNA 2GZEA 2GZFA 3DS1A 3I56P 4M0IA 2JYLA 2GYKA 2K93A 4HKGA 3M1MA 3H0DA 1EOQA 4R0MA 3Q20A 2M8LA 3LRYA 2JU1A 2Z46A 3DS2A 2KGCA 3CCVP 2KORA 3CXCO 5BS1A 3G0VA 3EJBA 4BPFA 3MGEA 1BAJA 2AFDA 2XZ0D 2L0QA 4PH1A 2PEKA 2K5XA 1RNIA 1NQ4A 3CD6P 1K73Q 4GR6A 2FQ2A 2AFEA 4WYMA 5HV8A 3NTEA 2GZJA 3EJDA 2FADA 3CCMP 1D1DA 2EHSA 2PEQA 1GXGA 2KG6A 2MR7A 2JO0A 1VQOP 2N50A 2N6ZA 4UHPB 1KD1Q 3G4SP 1VQ7P 1YJNP 3CC7P 2KWLA 4PH0A 2K2QA 2FHSC 2ROQA 2N5HA 2GDXA 1VQ6P 5BS2A 2VLQA 2L9FA 2VLPA 5KP6B 2MVUA 3DTJA 2LF4A 2CG5B 2PEMA 2KW2A 4NEOA 3CCUP 1Q86Q 2FVAA 4XFXA 4IZ6A 2VSQA 2N6YA 2FQ1A 1VQ9P 5HGLA 3CCJP 3RG6C 2PEJA 1AYIA 4PXHB 2EFJA 5HVCA 2PEOA 1VQ5P 2CWOA 1F80D 3H4EA 2QNWA 4U0DA 2PENA 1VQPP 2AF8A 4XFYA 1VQLP 2GZGA 5DCKA 3G26A 4COCA 1L0HA 1W2BO 1VQKP 2OARA 2FACA 1YI2P 5F2OA 7CEIA 1YJWP 2KR5A 2FAEA 3DS4A 3H47A 5HGNA 3G71P 1T8KA 3CCRP 1AF8A 4XRQA 1M6EX 2MD9A 2MF4A 2LKIA 3GJNA 1RO2A 2EIAA 2M8NA 2WPTA 4MRTC 1UNKA 2FVFA 2PEIA 2MY5A 1IUQA 2LPKA 4F37A 3EJEA
chains in the Genus database with same CATH topology
3U43A 1BXIA 1IMPA 2GYKA 2GZIA 1GXHA 3GKLC 4UHPB 2K5XA 2VLOA 2K0DX 2GZGA 1ZNVA 2JB0A 3GJNA 2JBGA 1FR2A 2NO8A 1E0HA 2VLQA 2WPTA 1UNKA 2GZJA 1CEIA 2VLNA 2GZEA 2GZFA 2VLPA 7CEIA 1IMQA 1MZ8A 1GXGA 1UJZA 5EW5E 4F37A 2ERHA 4QKOA 1AYIA 2JAZA 1EMVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3U43 A;  1BXI A;  1IMP A;  2GYK A;  2GZI A;  1GXH A;  3GKL C;  4UHP B;  2K5X A;  2VLO A;  2K0D X;  2GZG A;  1ZNV A;  2JB0 A;  3GJN A;  2JBG A;  1FR2 A;  2NO8 A;  1E0H A;  2VLQ A;  2WPT A;  1UNK A;  2GZJ A;  1CEI A;  2VLN A;  2GZE A;  2GZF A;  2VLP A;  7CEI A;  1IMQ A;  1MZ8 A;  1GXG A;  1UJZ A;  5EW5 E;  4F37 A;  2ERH A;  4QKO A;  1AYI A;  2JAZ A;  1EMV A; 
#chains in the Genus database with same CATH topology
 2M8P A;  4QNB A;  1NJI Q;  3GKL C;  3B5I A;  3I55 P;  2CNR A;  2XZ1 C;  3P05 A;  4GR2 A;  1ZNV A;  4PWV B;  2ONT A;  1DNY A;  1K8A Q;  1OR5 A;  2NO8 A;  2XT1 A;  4U0E A;  1HY8 A;  3OW2 O;  1QVG O;  4H2W C;  3VRL C;  2LTE A;  1MZ8 A;  3G1G A;  2L4B A;  3G6E P;  1IMP A;  2OTJ P;  5CZD B;  2KG9 A;  3GZL A;  3LMO A;  3CCL P;  5EJD A;  5I4T G;  2GDW A;  3DS5 A;  2PY8 A;  2X2B A;  1K30 A;  2LIU A;  2K92 A;  2EG5 A;  2FQ0 A;  3CE7 A;  4U0B A;  2LL8 A;  3CMA P;  2KOP A;  3DS3 A;  1N8R Q;  2Z44 A;  1K9M Q;  1YIJ P;  4BPG A;  1Q81 Q;  2Z45 A;  2BHV A;  5HGM A;  1EIA A;  2DNW A;  1RO0 A;  1YJ9 P;  1M6N A;  4U0A A;  2JB0 A;  1VHN A;  3GZM A;  1L0I A;  2K94 A;  5EW5 E;  2JQ4 A;  2KOS A;  1EMV A;  2JGP A;  1AUM A;  2K0X A;  3E2D A;  2CQ8 A;  3RG2 A;  2N5I A;  2K0D X;  2QA4 P;  1VQ4 P;  1VQ8 P;  2LIW A;  1QRJ A;  1YHQ P;  3G1I A;  3DPH A;  1M90 Q;  3DS0 A;  1S72 P;  3B4Q A;  4H2Y C;  5JPA A;  4CA3 A;  1A43 A;  5KP7 B;  3HZQ A;  2BUO A;  2K0Y A;  2AVA A;  4XRO A;  1IMQ A;  1UJZ A;  3CC4 P;  1E6J P;  2L22 A;  2ERH A;  4QKO A;  2JAZ A;  2MVV A;  4IPY A;  1M1K Q;  2VLO A;  3CPW O;  4BPH A;  2MR8 A;  1DV5 A;  2E1M A;  2KOD A;  1A8O A;  4U0C A;  2KGA A;  1CEI A;  1YIT P;  1ZMB A;  4H2X C;  4DG9 A;  1KQS O;  1JJ2 O;  3U43 A;  1BXI A;  2KOQ A;  2GZI A;  1GXH A;  2EHT A;  1KC8 Q;  2XV6 A;  1Q82 Q;  1VQM P;  2QEX P;  2KOO A;  2KG8 A;  4XFZ A;  1KLP A;  5HGO A;  1M74 A;  1QVF O;  1GPJ A;  2KGE A;  2OTL P;  1ACP A;  1VKU A;  3CCE P;  5F2K A;  1VQN P;  3G29 A;  2L6E A;  2LML A;  2KGD A;  5KP8 B;  4COP A;  2M5R A;  2PNG A;  2JBG A;  2XXM A;  2LOL A;  1FR2 A;  2N98 A;  2P9X A;  1E0H A;  3NY7 B;  2JU2 A;  3CC2 P;  3HYB A;  3CME P;  1HQB A;  1Z6M A;  4U0F A;  3G21 A;  2JYG A;  5F2N A;  2GDY A;  3CCQ P;  3CCS P;  1X3O A;  2DGY A;  2CGQ A;  1Q7Y Q;  2FVE A;  3G28 A;  3WBH A;  2VLN A;  2GZE A;  2GZF A;  3DS1 A;  3I56 P;  4M0I A;  2JYL A;  2GYK A;  2K93 A;  4HKG A;  3M1M A;  3H0D A;  1EOQ A;  4R0M A;  3Q20 A;  2M8L A;  3LRY A;  2JU1 A;  2Z46 A;  3DS2 A;  2KGC A;  3CCV P;  2KOR A;  3CXC O;  5BS1 A;  3G0V A;  3EJB A;  4BPF A;  3MGE A;  1BAJ A;  2AFD A;  2XZ0 D;  2L0Q A;  4PH1 A;  2PEK A;  2K5X A;  1RNI A;  1NQ4 A;  3CD6 P;  1K73 Q;  4GR6 A;  2FQ2 A;  2AFE A;  4WYM A;  5HV8 A;  3NTE A;  2GZJ A;  3EJD A;  2FAD A;  3CCM P;  1D1D A;  2EHS A;  2PEQ A;  1GXG A;  2KG6 A;  2MR7 A;  2JO0 A;  1VQO P;  2N50 A;  2N6Z A;  4UHP B;  1KD1 Q;  3G4S P;  1VQ7 P;  1YJN P;  3CC7 P;  2KWL A;  4PH0 A;  2K2Q A;  2FHS C;  2ROQ A;  2N5H A;  2GDX A;  1VQ6 P;  5BS2 A;  2VLQ A;  2L9F A;  2VLP A;  5KP6 B;  2MVU A;  3DTJ A;  2LF4 A;  2CG5 B;  2PEM A;  2KW2 A;  4NEO A;  3CCU P;  1Q86 Q;  2FVA A;  4XFX A;  4IZ6 A;  2VSQ A;  2N6Y A;  2FQ1 A;  1VQ9 P;  5HGL A;  3CCJ P;  3RG6 C;  2PEJ A;  1AYI A;  4PXH B;  2EFJ A;  5HVC A;  2PEO A;  1VQ5 P;  2CWO A;  1F80 D;  3H4E A;  2QNW A;  4U0D A;  2PEN A;  1VQP P;  2AF8 A;  4XFY A;  1VQL P;  2GZG A;  5DCK A;  3G26 A;  4COC A;  1L0H A;  1W2B O;  1VQK P;  2OAR A;  2FAC A;  1YI2 P;  5F2O A;  7CEI A;  1YJW P;  2KR5 A;  2FAE A;  3DS4 A;  3H47 A;  5HGN A;  3G71 P;  1T8K A;  3CCR P;  1AF8 A;  4XRQ A;  1M6E X;  2MD9 A;  2MF4 A;  2LKI A;  3GJN A;  1RO2 A;  2EIA A;  2M8N A;  2WPT A;  4MRT C;  1UNK A;  2FVF A;  2PEI A;  2MY5 A;  1IUQ A;  2LPK A;  4F37 A;  3EJE A; 
#chains in the Genus database with same CATH homology
 3U43 A;  1BXI A;  1IMP A;  2GYK A;  2GZI A;  1GXH A;  3GKL C;  4UHP B;  2K5X A;  2VLO A;  2K0D X;  2GZG A;  1ZNV A;  2JB0 A;  3GJN A;  2JBG A;  1FR2 A;  2NO8 A;  1E0H A;  2VLQ A;  2WPT A;  1UNK A;  2GZJ A;  1CEI A;  2VLN A;  2GZE A;  2GZF A;  2VLP A;  7CEI A;  1IMQ A;  1MZ8 A;  1GXG A;  1UJZ A;  5EW5 E;  4F37 A;  2ERH A;  4QKO A;  1AYI A;  2JAZ A;  1EMV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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