3CXCO

The structure of an enhanced oxazolidinone inhibitor bound to the 50s ribosomal subunit of h. marismortui
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
143
structure length
143
Chain Sequence
TDLSAQKRLAADVLDVGKNRVWFNPERQGDIADAITREDVRELVDEGAIQAKDKKGNSRGRARERQKKRAKGHQKGAGSRKGKAGARQNSKEDWESRIRAQRTKLRELRDEGTLSSSQYRDLYDKAGGGEFDSVADLERYIDA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S RIBOSOMAL RNA
total genus 50
structure length 143
sequence length 143
ec nomenclature
pdb deposition date 2008-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
O PF01280 Ribosomal_L19e Ribosomal protein L19e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1200.60 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A 3cxcO02
1.10.1650.10 Mainly Alpha Orthogonal Bundle 50s Ribosomal Protein L19e, Chain O, domain 1 50s Ribosomal Protein L19e, Chain O, domain 1 3cxcO01
3CXCO 1VQ4P 3CC7P 3CC4P 1W2BO 1VQ7P 3CCMP 3G4SP 1S72P 1K8AQ 1K9MQ 1VQNP 1YJWP 3I55P 3OW2O 1QVGO 1YI2P 1M1KQ 1JJ2O 3CCVP 1VQ5P 3CMEP 1YJ9P 3CD6P 3CCSP 1VQKP 3CCJP 2OTLP 1KD1Q 2QEXP 3G71P 3CCRP 3I56P 1YITP 3CCLP 1YHQP 3G6EP 1YIJP 1KC8Q 1QVFO 2OTJP 1VQ9P 1Q82Q 1Q81Q 1K73Q 2QA4P 1KQSO 1M90Q 1VQ8P 3CCEP 3CCQP 1VQOP 1NJIQ 1Q86Q 3CMAP 3CCUP 1VQ6P 1VQMP 1VQLP 1N8RQ 1Q7YQ 3CPWO 3CC2P 1YJNP 1VQPP
chains in the Genus database with same CATH superfamily
3CCMP 7CEIA 2L4BA 1K9MQ 2K5XA 3CMEP 1E0HA 2OTLP 2ROQA 2QEXP 2GZJA 2GZGA 2M8PA 1K73Q 2AF8A 3DTJA 2XZ1C 1RO0A 2FVFA 1RNIA 4U0EA 4U0CA 2ERHA 3VRLC 2GDYA 3B4QA 5HGLA 2WPTA 2PENA 3GZMA 1MZ8A 3CE7A 2EG5A 5KP6B 2PEJA 2CWOA 4HKGA 2JQ4A 4XFYA 2MD9A 4PH1A 2MR7A 2KOPA 1VQ5P 1NQ4A 2AVAA 1VQKP 5HGNA 1PEQA 1KD1Q 3G71P 1YITP 4QKOA 1PEOA 1UJZA 2FQ2A 2KGEA 1VKUA 5EW5E 3CPWO 3CC2P 2LTEA 1VQ7P 1BXIA 4NEOA 4BPFA 1QVGO 2KORA 2KGDA 1ACPA 3GJNA 2VLPA 2FAEA 3H47A 2CGQA 1Q81Q 3CCEP 2L9FA 3G21A 2BHVA 5KP7B 2M5RA 3MGEA 3H4EA 2LKIA 5CZDB 2ONTA 3EJBA 3G4SP 4U0DA 2LIWA 1PEMA 1M6EX 5JPAA 3DPHA 4BPGA 2GZFA 4U0FA 1M74A 2BUOA 3WBHA 2L6EA 3I55P 2FVEA 3CCVP 1IUQA 1YJ9P 2N50A 3G6EP 2QA4P 2EFJA 4IZ6A 3CMAP 2BQ1E 1HQBA 2AFDA 3CXCO 1A8OA 3CC4P 1L0HA 2KGCA 4XROA 1BAJA 2VLQA 3G29A 3Q20A 3CCLP 1GPJA 2XT1A 1QVFO 2FQ0A 1VQ9P 2CG5B 1Q82Q 2K0YA 2PEMA 3CCQP 1Q86Q 2XV6A 5HGMA 3EJEA 2LF4A 4XFZA 4WYMA 3NY7B 2FADA 4XRQA 1YI2P 4DG9A 3GZLA 3CD6P 2N6ZA 1PEUA 2EHTA 3DS0A 2KOQA 3G1GA 2MVUA 1DV5A 2EHSA 1VQOP 2JB0A 1F80D 1IMQA 1HY8A 3RG6C 4F37A 3NTEA 3HYBA 5HGOA 2N6YA 2CNRA 2KWLA 4U0AA 2MF4A 1VHNA 2XZ0D 1FR2A 2DNWA 5EJDA 2M8LA 4GR2A 4BPHA 2EIAA 5HVCA 2JAZA 2Z44A 1ZNVA 2LL8A 4H2YC 1VQNP 2XXMA 3G26A 3LMOA 1RO2A 2L0QA 2KOOA 2VLOA 2M8NA 4PWVB 5HV8A 1GXGA 4PXHB 4PH0A 1AF8A 2GZIA 1K8AQ 5BS1A 2LMLA 3B5IA 3DS4A 2GZEA 2VLNA 5I4TG 3DS5A 2GYKA 1Z6MA 3DS3A 2FHSC 4QNBA 2MR8A 5DCKA 2N98A 3DS1A 1D1DA 3E2DA 3RG2A 1DNYA 1N8RQ 4M0IA 2PNGA 1T8KA 4GR6A 1S72P 2E1MA 2FVAA 3OW2O 2KW2A 2FACA 2MY5A 1UNKA 2CQ8A 2K0XA 1A43A 2KGAA 2DGYA 2Z45A 2FQ1A 5KP8B 2OARA 2Z46A 3M1MA 3I56P 3CCRP 2OTJP 3G1IA 2PEQA 2KODA 1VQ6P 1VQMP 4IPYA 2GDWA 2X2BA 3CC7P 2LIUA 2JYGA 1M1KQ 1JJ2O 2PY8A 2KG6A 4H2XC 2P9XA 2PEIA 2AFEA 3CCSP 3LRYA 1OR5A 1CEIA 1EMVA 1GXHA 1YIJP 2N5HA 2PEOA 1KQSO 1L0IA 1VQ8P 3H0DA 1QRJA 2VSQA 1Q7YQ 2MVVA 1VQ4P 4XFXA 1E6JP 4R0MA 2GDXA 3DS2A 2KG8A 4COPA 1AYIA 1AUMA 2LOLA 3CCJP 2LPKA 2K0DX 5BS2A 2L22A 2JU2A 3U43A 1ZMBA 2N5IA 3CCUP 1M6NA 1VQLP 2KR5A 4CA3A 2K2QA 2K92A 3G0VA 1EOQA 4COCA 2K94A 2KG9A 2K93A 3G28A 4MRTC 2JO0A 1K30A 1YHQP 1KC8Q 2JGPA 2QNWA 1EIAA 5F2NA 3GKLC 5F2OA 1YJNP 1IMPA 2JYLA 1W2BO 5F2KA 1YJWP 2PEKA 2JU1A 2JBGA 1KLPA 4UHPB 3P05A 2KOSA 3HZQA 4U0BA 3EJDA 1M90Q 1NJIQ 4H2WC 2NO8A 1X3OA 1VQPP
chains in the Genus database with same CATH topology
3H4EA 3CC7P 2ONTA 3CCMP 3G4SP 4U0DA 1K9MQ 2JYGA 3RG6C 1M1KQ 1JJ2O 3CMEP 2PY8A 3NTEA 3HYBA 2P9XA 2PEIA 3CCSP 1PEMA 3LRYA 2OTLP 2QEXP 1M6EX 1YIJP 2M8PA 5HGOA 1K73Q 2PEOA 1KQSO 5JPAA 3DPHA 4U0AA 4U0FA 3DTJA 1VQ8P 1RO0A 1RNIA 1M74A 1QRJA 2M8LA 4U0EA 3H0DA 4U0CA 4GR2A 3VRLC 1Q7YQ 2EIAA 2Z44A 2BUOA 1VQ4P 3WBHA 4XFXA 1VQNP 1E6JP 2XXMA 2L6EA 3I55P 3DS2A 3G26A 3CCVP 5HGLA 1RO2A 1IUQA 4COPA 1YJ9P 1AUMA 2PENA 3CCJP 5BS2A 3G6EP 2EG5A 2M8NA 2QA4P 2EFJA 2PEJA 2CWOA 1ZMBA 4PH0A 3CMAP 4XFYA 3CCUP 1M6NA 1VQLP 2BQ1E 3CXCO 1A8OA 4PH1A 3CC4P 1K8AQ 4XROA 5BS1A 3G0VA 3B5IA 1EOQA 1BAJA 3DS4A 4COCA 5I4TG 1VQ5P 3DS5A 3G29A 3G28A 2JO0A 1VQKP 1K30A 5HGNA 3Q20A 1PEQA 1KD1Q 3G71P 1YITP 3CCLP 2XT1A 1YHQP 1KC8Q 1QVFO 3DS3A 4QNBA 1Q82Q 1VQ9P 1PEOA 1EIAA 2PEMA 5DCKA 3CCQP 3DS1A 1D1DA 5F2NA 3E2DA 1Q86Q 5F2OA 1N8RQ 4M0IA 3CPWO 3CC2P 2XV6A 1YJNP 2JYLA 5HGMA 2LF4A 1W2BO 4GR6A 4XFZA 1VQ7P 4WYMA 1S72P 2E1MA 5F2KA 2PEKA 4XRQA 1YJWP 3OW2O 1QVGO 1YI2P 3P05A 3CD6P 3HZQA 1A43A 1PEUA 2DGYA 4U0BA 2Z45A 2OARA 2Z46A 3M1MA 3I56P 3CCRP 3DS0A 3H47A 2OTJP 1Q81Q 3G1GA 1M90Q 3G1IA 3CCEP 2PEQA 1VQOP 1NJIQ 2KODA 3G21A 1VQ6P 2BHVA 4IPYA 1VQMP 1VQPP 3MGEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CXC O;  1VQ4 P;  3CC7 P;  3CC4 P;  1W2B O;  1VQ7 P;  3CCM P;  3G4S P;  1S72 P;  1K8A Q;  1K9M Q;  1VQN P;  1YJW P;  3I55 P;  3OW2 O;  1QVG O;  1YI2 P;  1M1K Q;  1JJ2 O;  3CCV P;  1VQ5 P;  3CME P;  1YJ9 P;  3CD6 P;  3CCS P;  1VQK P;  3CCJ P;  2OTL P;  1KD1 Q;  2QEX P;  3G71 P;  3CCR P;  3I56 P;  1YIT P;  3CCL P;  1YHQ P;  3G6E P;  1YIJ P;  1KC8 Q;  1QVF O;  2OTJ P;  1VQ9 P;  1Q82 Q;  1Q81 Q;  1K73 Q;  2QA4 P;  1KQS O;  1M90 Q;  1VQ8 P;  3CCE P;  3CCQ P;  1VQO P;  1NJI Q;  1Q86 Q;  3CMA P;  3CCU P;  1VQ6 P;  1VQM P;  1VQL P;  1N8R Q;  1Q7Y Q;  3CPW O;  3CC2 P;  1YJN P;  1VQP P; 
#chains in the Genus database with same CATH topology
 3CCM P;  7CEI A;  2L4B A;  1K9M Q;  2K5X A;  3CME P;  1E0H A;  2OTL P;  2ROQ A;  2QEX P;  2GZJ A;  2GZG A;  2M8P A;  1K73 Q;  2AF8 A;  3DTJ A;  2XZ1 C;  1RO0 A;  2FVF A;  1RNI A;  4U0E A;  4U0C A;  2ERH A;  3VRL C;  2GDY A;  3B4Q A;  5HGL A;  2WPT A;  2PEN A;  3GZM A;  1MZ8 A;  3CE7 A;  2EG5 A;  5KP6 B;  2PEJ A;  2CWO A;  4HKG A;  2JQ4 A;  4XFY A;  2MD9 A;  4PH1 A;  2MR7 A;  2KOP A;  1VQ5 P;  1NQ4 A;  2AVA A;  1VQK P;  5HGN A;  1PEQ A;  1KD1 Q;  3G71 P;  1YIT P;  4QKO A;  1PEO A;  1UJZ A;  2FQ2 A;  2KGE A;  1VKU A;  5EW5 E;  3CPW O;  3CC2 P;  2LTE A;  1VQ7 P;  1BXI A;  4NEO A;  4BPF A;  1QVG O;  2KOR A;  2KGD A;  1ACP A;  3GJN A;  2VLP A;  2FAE A;  3H47 A;  2CGQ A;  1Q81 Q;  3CCE P;  2L9F A;  3G21 A;  2BHV A;  5KP7 B;  2M5R A;  3MGE A;  3H4E A;  2LKI A;  5CZD B;  2ONT A;  3EJB A;  3G4S P;  4U0D A;  2LIW A;  1PEM A;  1M6E X;  5JPA A;  3DPH A;  4BPG A;  2GZF A;  4U0F A;  1M74 A;  2BUO A;  3WBH A;  2L6E A;  3I55 P;  2FVE A;  3CCV P;  1IUQ A;  1YJ9 P;  2N50 A;  3G6E P;  2QA4 P;  2EFJ A;  4IZ6 A;  3CMA P;  2BQ1 E;  1HQB A;  2AFD A;  3CXC O;  1A8O A;  3CC4 P;  1L0H A;  2KGC A;  4XRO A;  1BAJ A;  2VLQ A;  3G29 A;  3Q20 A;  3CCL P;  1GPJ A;  2XT1 A;  1QVF O;  2FQ0 A;  1VQ9 P;  2CG5 B;  1Q82 Q;  2K0Y A;  2PEM A;  3CCQ P;  1Q86 Q;  2XV6 A;  5HGM A;  3EJE A;  2LF4 A;  4XFZ A;  4WYM A;  3NY7 B;  2FAD A;  4XRQ A;  1YI2 P;  4DG9 A;  3GZL A;  3CD6 P;  2N6Z A;  1PEU A;  2EHT A;  3DS0 A;  2KOQ A;  3G1G A;  2MVU A;  1DV5 A;  2EHS A;  1VQO P;  2JB0 A;  1F80 D;  1IMQ A;  1HY8 A;  3RG6 C;  4F37 A;  3NTE A;  3HYB A;  5HGO A;  2N6Y A;  2CNR A;  2KWL A;  4U0A A;  2MF4 A;  1VHN A;  2XZ0 D;  1FR2 A;  2DNW A;  5EJD A;  2M8L A;  4GR2 A;  4BPH A;  2EIA A;  5HVC A;  2JAZ A;  2Z44 A;  1ZNV A;  2LL8 A;  4H2Y C;  1VQN P;  2XXM A;  3G26 A;  3LMO A;  1RO2 A;  2L0Q A;  2KOO A;  2VLO A;  2M8N A;  4PWV B;  5HV8 A;  1GXG A;  4PXH B;  4PH0 A;  1AF8 A;  2GZI A;  1K8A Q;  5BS1 A;  2LML A;  3B5I A;  3DS4 A;  2GZE A;  2VLN A;  5I4T G;  3DS5 A;  2GYK A;  1Z6M A;  3DS3 A;  2FHS C;  4QNB A;  2MR8 A;  5DCK A;  2N98 A;  3DS1 A;  1D1D A;  3E2D A;  3RG2 A;  1DNY A;  1N8R Q;  4M0I A;  2PNG A;  1T8K A;  4GR6 A;  1S72 P;  2E1M A;  2FVA A;  3OW2 O;  2KW2 A;  2FAC A;  2MY5 A;  1UNK A;  2CQ8 A;  2K0X A;  1A43 A;  2KGA A;  2DGY A;  2Z45 A;  2FQ1 A;  5KP8 B;  2OAR A;  2Z46 A;  3M1M A;  3I56 P;  3CCR P;  2OTJ P;  3G1I A;  2PEQ A;  2KOD A;  1VQ6 P;  1VQM P;  4IPY A;  2GDW A;  2X2B A;  3CC7 P;  2LIU A;  2JYG A;  1M1K Q;  1JJ2 O;  2PY8 A;  2KG6 A;  4H2X C;  2P9X A;  2PEI A;  2AFE A;  3CCS P;  3LRY A;  1OR5 A;  1CEI A;  1EMV A;  1GXH A;  1YIJ P;  2N5H A;  2PEO A;  1KQS O;  1L0I A;  1VQ8 P;  3H0D A;  1QRJ A;  2VSQ A;  1Q7Y Q;  2MVV A;  1VQ4 P;  4XFX A;  1E6J P;  4R0M A;  2GDX A;  3DS2 A;  2KG8 A;  4COP A;  1AYI A;  1AUM A;  2LOL A;  3CCJ P;  2LPK A;  2K0D X;  5BS2 A;  2L22 A;  2JU2 A;  3U43 A;  1ZMB A;  2N5I A;  3CCU P;  1M6N A;  1VQL P;  2KR5 A;  4CA3 A;  2K2Q A;  2K92 A;  3G0V A;  1EOQ A;  4COC A;  2K94 A;  2KG9 A;  2K93 A;  3G28 A;  4MRT C;  2JO0 A;  1K30 A;  1YHQ P;  1KC8 Q;  2JGP A;  2QNW A;  1EIA A;  5F2N A;  3GKL C;  5F2O A;  1YJN P;  1IMP A;  2JYL A;  1W2B O;  5F2K A;  1YJW P;  2PEK A;  2JU1 A;  2JBG A;  1KLP A;  4UHP B;  3P05 A;  2KOS A;  3HZQ A;  4U0B A;  3EJD A;  1M90 Q;  1NJI Q;  4H2W C;  2NO8 A;  1X3O A;  1VQP P; 
#chains in the Genus database with same CATH homology
 3H4E A;  3CC7 P;  2ONT A;  3CCM P;  3G4S P;  4U0D A;  1K9M Q;  2JYG A;  3RG6 C;  1M1K Q;  1JJ2 O;  3CME P;  2PY8 A;  3NTE A;  3HYB A;  2P9X A;  2PEI A;  3CCS P;  1PEM A;  3LRY A;  2OTL P;  2QEX P;  1M6E X;  1YIJ P;  2M8P A;  5HGO A;  1K73 Q;  2PEO A;  1KQS O;  5JPA A;  3DPH A;  4U0A A;  4U0F A;  3DTJ A;  1VQ8 P;  1RO0 A;  1RNI A;  1M74 A;  1QRJ A;  2M8L A;  4U0E A;  3H0D A;  4U0C A;  4GR2 A;  3VRL C;  1Q7Y Q;  2EIA A;  2Z44 A;  2BUO A;  1VQ4 P;  3WBH A;  4XFX A;  1VQN P;  1E6J P;  2XXM A;  2L6E A;  3I55 P;  3DS2 A;  3G26 A;  3CCV P;  5HGL A;  1RO2 A;  1IUQ A;  4COP A;  1YJ9 P;  1AUM A;  2PEN A;  3CCJ P;  5BS2 A;  3G6E P;  2EG5 A;  2M8N A;  2QA4 P;  2EFJ A;  2PEJ A;  2CWO A;  1ZMB A;  4PH0 A;  3CMA P;  4XFY A;  3CCU P;  1M6N A;  1VQL P;  2BQ1 E;  3CXC O;  1A8O A;  4PH1 A;  3CC4 P;  1K8A Q;  4XRO A;  5BS1 A;  3G0V A;  3B5I A;  1EOQ A;  1BAJ A;  3DS4 A;  4COC A;  5I4T G;  1VQ5 P;  3DS5 A;  3G29 A;  3G28 A;  2JO0 A;  1VQK P;  1K30 A;  5HGN A;  3Q20 A;  1PEQ A;  1KD1 Q;  3G71 P;  1YIT P;  3CCL P;  2XT1 A;  1YHQ P;  1KC8 Q;  1QVF O;  3DS3 A;  4QNB A;  1Q82 Q;  1VQ9 P;  1PEO A;  1EIA A;  2PEM A;  5DCK A;  3CCQ P;  3DS1 A;  1D1D A;  5F2N A;  3E2D A;  1Q86 Q;  5F2O A;  1N8R Q;  4M0I A;  3CPW O;  3CC2 P;  2XV6 A;  1YJN P;  2JYL A;  5HGM A;  2LF4 A;  1W2B O;  4GR6 A;  4XFZ A;  1VQ7 P;  4WYM A;  1S72 P;  2E1M A;  5F2K A;  2PEK A;  4XRQ A;  1YJW P;  3OW2 O;  1QVG O;  1YI2 P;  3P05 A;  3CD6 P;  3HZQ A;  1A43 A;  1PEU A;  2DGY A;  4U0B A;  2Z45 A;  2OAR A;  2Z46 A;  3M1M A;  3I56 P;  3CCR P;  3DS0 A;  3H47 A;  2OTJ P;  1Q81 Q;  3G1G A;  1M90 Q;  3G1I A;  3CCE P;  2PEQ A;  1VQO P;  1NJI Q;  2KOD A;  3G21 A;  1VQ6 P;  2BHV A;  4IPY A;  1VQM P;  1VQP P;  3MGE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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