1F93A

Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
103
structure length
103
Chain Sequence
AGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.
pubmed doi rcsb
molecule tags Transcription
source organism Rattus norvegicus
molecule keywords DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
total genus 32
structure length 103
sequence length 103
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase.
pdb deposition date 2000-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01329 Pterin_4a Pterin 4 alpha carbinolamine dehydratase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1360.20 Alpha Beta 2-Layer Sandwich Gyrase A; domain 2 Transcriptional coactivator/pterin dehydratase 1f93A00
1USOA 2V6SA 1DCPA 2EBBA 2V6UA 1F93A 3HXAA 1DCHA 4C45A 1RU0A 4LOWA 3JSTA 4WILA 2V6TA 1DCOA 1USMA
chains in the Genus database with same CATH superfamily
4BLAA 3GIRA 1EFWA 1C0AA 1K83K 1INNA 1TWAC 1TWGC 2EBBA 2P5MA 4A3KK 4OINA 1I3QA 3GTKA 4WJ3M 3Q3QA 1BS2A 4A3DC 3HOXK 3AD8C 1GE9A 1TWFC 1O2BA 5D4DA 4LOWA 4BY7K 1K83C 1VLOA 4WILA 2W7VA 4GT9A 3S1MC 4OIQA 3K7AK 3HOXC 2GAHC 2JA6K 1XZQB 1X31C 5C44K 3S2HC 3I4NK 5JVOA 1IL2A 4Q4ZA 3GDZA 3K7AC 2V6TA 4QJVA 2VUMK 2JA6C 5C4XK 1EK8A 1J6VA 2D6FC 4P5BA 3A8KA 5C44C 3GTMA 5IOSA 2NVTK 1TWHA 3I4NC 4LK0A 4Y7NK 4LQYA 3S16C 5C4XC 4PABA 3OPFA 2NVTC 1YNNA 3S14K 3S1NK 1BGWA 2KWAA 2PMZL 4XSXA 3T02A 1RU0A 1KQ4A 4LJZA 3QX3A 3S1NC 1I6HC 1R9TA 2A6HA 3OEPA 3ADAC 3PO2C 1O27A 1I3QK 3GTKK 4GTDA 3HOUK 4QJVB 1DCOA 1WQHA 3CAGA 2JA7K 4KB2A 1I3QC 3GTKC 4RMFA 4C3JK 1EI6A 4MEXA 1F7VA 3HOUC 3HOVK 3GTPA 3GTGA 4KAWX 3TFIA 3HKZL 2GSUA 2JA8C 2CFAA 3M3YC 4GTFA 4WJ4A 4GTEA 4Y52K 2R93A 2PPBA 2YU9A 3BUEA 4C3JC 1USMA 3HOVC 4GTAA 2NVXA 4C3HC 3GTMK 1TWHK 5IOQA 3LAJA 4Y52C 4YFKA 4ILDA 3A8JA 4KMDA 3H0GA 2WAQD 3M4OK 1L0WA 3GTMC 5M3FK 1TWHC 3GTLA 5EGEA 3SZYA 3LPXA 2A69A 3GTQA 1O24A 2NVYA 3MMLB 1TWFK 3M4OC 5IP7C 3CQZA 3FOFA 2P8TA 3IPJA 4BKWA 1XZPB 5IP9C 1R9TK 3AQPA 2CFAB 2FQTA 1F9NA 3EQLA 2E2IA 3AH5A 3S2HK 4GTBA 1HQMA 4XLNA 4KMAA 1R9TC 3G4AA 4QIWD 1VJEA 4KDDA 4A93K 5IYDK 4JK1A 4G0UA 4A3GK 3FKIA 4KB4A 1WORA 1TWCA 3GEIA 2CW0A 4YG2A 2R93K 3S16K 2YU9K 4A93C 5IYDC 3N3YA 2ZFZA 3GTPC 4GTLA 3GTGC 1IE0A 1VH2A 2NVXK 4A3GC 1WQGA 1SFOA 2A6EA 4J3NA 1DCHA 3S15C 3NUHA 4MEYA 3AD7C 2JA5A 2R93C 2YU9C 3H0GK 2GAGC 3WODA 2E2JK 2NVXC 1WIHA 3HOZK 5CHPA 3GEHA 1I6HK 4GFQA 2E2HK 3GTLK 4BBSC 1Y1VA 2ZUFA 5M5XK 3S1RK 4P5AA 3HOYC 3PO2K 2PA8D 3H0GC 3GTQK 2GSNA 3S1QC 4G0WA 1IQ0A 1ZXOA 2NVYK 5C3EK 4A3BK 2E2JC 3HOZC 1IW7A 4BBRC 2R7ZA 1WOPA 1PJ6A 3GTLC 3TFHA 3RZOK 3S1RC 3CQZK 3GTOA 1I50A 2ZUEA 1ISEA 3GTQC 1TWAA 1PJ5A 3GSIA 2NVYC 5C3EC 4A3BC 4KATA 4OIPA 2E2IK 2E2HA 3RZOC 2JA8K 3CQZC 3M3YK 5FLMK 5TMCA 3L4JA 2O5JA 1BDFA 1WCMA 3BP8C 4AYBD 1O2AA 4C3HK 4G7OA 4A3IK 2E2IC 2XCQA 1O2FB 3FKIK 5FLMC 1WSRA 4FM9A 1VRQC 1DCPA 3RZDK 2Y0SD 2B63A 5IYBC 4A3IC 1XXAA 2XCOA 3T01A 3ERED 3FKIC 1SFOK 1BJTA 1WOOA 3RZDC 2JA5K 4X6AC 5IP7K 3H3VD 2VUMA 3TTGA 3S2DK 3SZZA 1SFOC 4KMHA 4KMUA 1Y1WA 5IP9K 1Y1VK 4A3MC 2JA5C 1J6WA 4ZH4A 2WB1D 4KASA 1JQWA 3AQOA 3S2DC 1XZQA 2WAQL 3JSTA 2PHCB 1ZQ1C 1Y1VC 3S17K 4MQ9A 1XPPA 1I50K 5L46A 1XXBA 2JH3A 4C2MK 2BE5A 4FZBA 4KN7A 1O26A 1AB4A 2WB1L 2R7ZC 3A8IA 5IOTA 5E68A 3S17C 1HI9A 3GTOC 1I50C 4KM8A 1O29A 4C2MC 2GSOA 1WCMK 2NVQK 1ZBSA 3GTPK 4OIOA 4KM9A 4KARA 3GTGK 2V6SA 5FJ8K 5CJ9A 2XCRB 5IYCC 2E2HC 3S15K 1EQRA 1WCMC 2NVQC 1B4AA 5HL8A 5JFEA 2JA7A 1V5VA 4A3KC 3PO3K 2RH6A 3GTJA 2B63K 4QIWL 4BBSK 3FOEA 4YFNA 3HOYK 1WOSA 4BY7C 3S1QK 3PO3C 4A3LK 3FHZA 4LR2A 2B63C 4OIRA 4BBRK 4XLPA 4Q5SA 4C45A 2R92A 4A3CK 1G51A 1Y1WK 2O5IA 1EH1A 1WQFA 2PMZD 1ZVUA 2A68A 4A3LC 3T00A 1WSVA 4A3JK 2VUMC 3G4CA 4BY1K 4A3CC 1Y1WC 3HXAA 2RGRA 3DXJA 1TWGA 1SMYA 4GTCA 5TMFA 4LK1A 4Y7NC 1IBAA 4O2DA 2PA8L 4A3JC 2Y3PA 3LAPA 1TWFA 4BY1C 3AD9C 1K83A 3S14C 4BXXK 5M3MK 1USOA 5IYBK 3HKZD 1JVIA 3BP3A 4C3IK 4GZYA 4YFXA 1XXCA 1IS1A 1TWCK 5M5WK 4P9SA 3L4KA 4BXXC 4X6AK 4PAAA 4KN4A 4G0VA 1J98A 4AH6A 3GTJK 3VA7A 2JA6A 4AYBL 1YNJA 4C3IC 1I6VA 4A3MK 1F93A 1TWCC 4XCHA 1XZPA 4DDQA 1F7UA 5C4JK 4XSZA 3HOWK 2JA7C 1O28A 4A3FK 3GTJC 1J6XA 2Y0SL 3TFJA 5M5YK 4A3EK 2V6UA 2R92K 5C4JC 3HOWC 1UV7A 5EGHA 3N0CA 3I4MK 4A3FC 1PJ7A 4G7ZA 1YX2A 2FQOA 2R7ZK 4LLGA 4A3EC 3S1MK 1YCLA 1JOEA 4BLBA 3GTOK 5IORA 2R92C 1O25A 3S0XA 3H3VL 3OREA 3GEEA 1TWAK 4M1XA 4G7HA 1TWGK 1VGXA 1DD5A 3N0BA 3I4MC 1B4BA 4NOIA 5IYCK 4KC6A 5TJ3A 3V4GA 4A3DK 1ZYRA
chains in the Genus database with same CATH topology
1USOA 2V6SA 1DCPA 2EBBA 2V6UA 1F93A 3HXAA 1DCHA 4C45A 1RU0A 4LOWA 3JSTA 4WILA 2V6TA 1DCOA 1USMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1USO A;  2V6S A;  1DCP A;  2EBB A;  2V6U A;  1F93 A;  3HXA A;  1DCH A;  4C45 A;  1RU0 A;  4LOW A;  3JST A;  4WIL A;  2V6T A;  1DCO A;  1USM A; 
#chains in the Genus database with same CATH topology
 4BLA A;  3GIR A;  1EFW A;  1C0A A;  1K83 K;  1INN A;  1TWA C;  1TWG C;  2EBB A;  2P5M A;  4A3K K;  4OIN A;  1I3Q A;  3GTK A;  4WJ3 M;  3Q3Q A;  1BS2 A;  4A3D C;  3HOX K;  3AD8 C;  1GE9 A;  1TWF C;  1O2B A;  5D4D A;  4LOW A;  4BY7 K;  1K83 C;  1VLO A;  4WIL A;  2W7V A;  4GT9 A;  3S1M C;  4OIQ A;  3K7A K;  3HOX C;  2GAH C;  2JA6 K;  1XZQ B;  1X31 C;  5C44 K;  3S2H C;  3I4N K;  5JVO A;  1IL2 A;  4Q4Z A;  3GDZ A;  3K7A C;  2V6T A;  4QJV A;  2VUM K;  2JA6 C;  5C4X K;  1EK8 A;  1J6V A;  2D6F C;  4P5B A;  3A8K A;  5C44 C;  3GTM A;  5IOS A;  2NVT K;  1TWH A;  3I4N C;  4LK0 A;  4Y7N K;  4LQY A;  3S16 C;  5C4X C;  4PAB A;  3OPF A;  2NVT C;  1YNN A;  3S14 K;  3S1N K;  1BGW A;  2KWA A;  2PMZ L;  4XSX A;  3T02 A;  1RU0 A;  1KQ4 A;  4LJZ A;  3QX3 A;  3S1N C;  1I6H C;  1R9T A;  2A6H A;  3OEP A;  3ADA C;  3PO2 C;  1O27 A;  1I3Q K;  3GTK K;  4GTD A;  3HOU K;  4QJV B;  1DCO A;  1WQH A;  3CAG A;  2JA7 K;  4KB2 A;  1I3Q C;  3GTK C;  4RMF A;  4C3J K;  1EI6 A;  4MEX A;  1F7V A;  3HOU C;  3HOV K;  3GTP A;  3GTG A;  4KAW X;  3TFI A;  3HKZ L;  2GSU A;  2JA8 C;  2CFA A;  3M3Y C;  4GTF A;  4WJ4 A;  4GTE A;  4Y52 K;  2R93 A;  2PPB A;  2YU9 A;  3BUE A;  4C3J C;  1USM A;  3HOV C;  4GTA A;  2NVX A;  4C3H C;  3GTM K;  1TWH K;  5IOQ A;  3LAJ A;  4Y52 C;  4YFK A;  4ILD A;  3A8J A;  4KMD A;  3H0G A;  2WAQ D;  3M4O K;  1L0W A;  3GTM C;  5M3F K;  1TWH C;  3GTL A;  5EGE A;  3SZY A;  3LPX A;  2A69 A;  3GTQ A;  1O24 A;  2NVY A;  3MML B;  1TWF K;  3M4O C;  5IP7 C;  3CQZ A;  3FOF A;  2P8T A;  3IPJ A;  4BKW A;  1XZP B;  5IP9 C;  1R9T K;  3AQP A;  2CFA B;  2FQT A;  1F9N A;  3EQL A;  2E2I A;  3AH5 A;  3S2H K;  4GTB A;  1HQM A;  4XLN A;  4KMA A;  1R9T C;  3G4A A;  4QIW D;  1VJE A;  4KDD A;  4A93 K;  5IYD K;  4JK1 A;  4G0U A;  4A3G K;  3FKI A;  4KB4 A;  1WOR A;  1TWC A;  3GEI A;  2CW0 A;  4YG2 A;  2R93 K;  3S16 K;  2YU9 K;  4A93 C;  5IYD C;  3N3Y A;  2ZFZ A;  3GTP C;  4GTL A;  3GTG C;  1IE0 A;  1VH2 A;  2NVX K;  4A3G C;  1WQG A;  1SFO A;  2A6E A;  4J3N A;  1DCH A;  3S15 C;  3NUH A;  4MEY A;  3AD7 C;  2JA5 A;  2R93 C;  2YU9 C;  3H0G K;  2GAG C;  3WOD A;  2E2J K;  2NVX C;  1WIH A;  3HOZ K;  5CHP A;  3GEH A;  1I6H K;  4GFQ A;  2E2H K;  3GTL K;  4BBS C;  1Y1V A;  2ZUF A;  5M5X K;  3S1R K;  4P5A A;  3HOY C;  3PO2 K;  2PA8 D;  3H0G C;  3GTQ K;  2GSN A;  3S1Q C;  4G0W A;  1IQ0 A;  1ZXO A;  2NVY K;  5C3E K;  4A3B K;  2E2J C;  3HOZ C;  1IW7 A;  4BBR C;  2R7Z A;  1WOP A;  1PJ6 A;  3GTL C;  3TFH A;  3RZO K;  3S1R C;  3CQZ K;  3GTO A;  1I50 A;  2ZUE A;  1ISE A;  3GTQ C;  1TWA A;  1PJ5 A;  3GSI A;  2NVY C;  5C3E C;  4A3B C;  4KAT A;  4OIP A;  2E2I K;  2E2H A;  3RZO C;  2JA8 K;  3CQZ C;  3M3Y K;  5FLM K;  5TMC A;  3L4J A;  2O5J A;  1BDF A;  1WCM A;  3BP8 C;  4AYB D;  1O2A A;  4C3H K;  4G7O A;  4A3I K;  2E2I C;  2XCQ A;  1O2F B;  3FKI K;  5FLM C;  1WSR A;  4FM9 A;  1VRQ C;  1DCP A;  3RZD K;  2Y0S D;  2B63 A;  5IYB C;  4A3I C;  1XXA A;  2XCO A;  3T01 A;  3ERE D;  3FKI C;  1SFO K;  1BJT A;  1WOO A;  3RZD C;  2JA5 K;  4X6A C;  5IP7 K;  3H3V D;  2VUM A;  3TTG A;  3S2D K;  3SZZ A;  1SFO C;  4KMH A;  4KMU A;  1Y1W A;  5IP9 K;  1Y1V K;  4A3M C;  2JA5 C;  1J6W A;  4ZH4 A;  2WB1 D;  4KAS A;  1JQW A;  3AQO A;  3S2D C;  1XZQ A;  2WAQ L;  3JST A;  2PHC B;  1ZQ1 C;  1Y1V C;  3S17 K;  4MQ9 A;  1XPP A;  1I50 K;  5L46 A;  1XXB A;  2JH3 A;  4C2M K;  2BE5 A;  4FZB A;  4KN7 A;  1O26 A;  1AB4 A;  2WB1 L;  2R7Z C;  3A8I A;  5IOT A;  5E68 A;  3S17 C;  1HI9 A;  3GTO C;  1I50 C;  4KM8 A;  1O29 A;  4C2M C;  2GSO A;  1WCM K;  2NVQ K;  1ZBS A;  3GTP K;  4OIO A;  4KM9 A;  4KAR A;  3GTG K;  2V6S A;  5FJ8 K;  5CJ9 A;  2XCR B;  5IYC C;  2E2H C;  3S15 K;  1EQR A;  1WCM C;  2NVQ C;  1B4A A;  5HL8 A;  5JFE A;  2JA7 A;  1V5V A;  4A3K C;  3PO3 K;  2RH6 A;  3GTJ A;  2B63 K;  4QIW L;  4BBS K;  3FOE A;  4YFN A;  3HOY K;  1WOS A;  4BY7 C;  3S1Q K;  3PO3 C;  4A3L K;  3FHZ A;  4LR2 A;  2B63 C;  4OIR A;  4BBR K;  4XLP A;  4Q5S A;  4C45 A;  2R92 A;  4A3C K;  1G51 A;  1Y1W K;  2O5I A;  1EH1 A;  1WQF A;  2PMZ D;  1ZVU A;  2A68 A;  4A3L C;  3T00 A;  1WSV A;  4A3J K;  2VUM C;  3G4C A;  4BY1 K;  4A3C C;  1Y1W C;  3HXA A;  2RGR A;  3DXJ A;  1TWG A;  1SMY A;  4GTC A;  5TMF A;  4LK1 A;  4Y7N C;  1IBA A;  4O2D A;  2PA8 L;  4A3J C;  2Y3P A;  3LAP A;  1TWF A;  4BY1 C;  3AD9 C;  1K83 A;  3S14 C;  4BXX K;  5M3M K;  1USO A;  5IYB K;  3HKZ D;  1JVI A;  3BP3 A;  4C3I K;  4GZY A;  4YFX A;  1XXC A;  1IS1 A;  1TWC K;  5M5W K;  4P9S A;  3L4K A;  4BXX C;  4X6A K;  4PAA A;  4KN4 A;  4G0V A;  1J98 A;  4AH6 A;  3GTJ K;  3VA7 A;  2JA6 A;  4AYB L;  1YNJ A;  4C3I C;  1I6V A;  4A3M K;  1F93 A;  1TWC C;  4XCH A;  1XZP A;  4DDQ A;  1F7U A;  5C4J K;  4XSZ A;  3HOW K;  2JA7 C;  1O28 A;  4A3F K;  3GTJ C;  1J6X A;  2Y0S L;  3TFJ A;  5M5Y K;  4A3E K;  2V6U A;  2R92 K;  5C4J C;  3HOW C;  1UV7 A;  5EGH A;  3N0C A;  3I4M K;  4A3F C;  1PJ7 A;  4G7Z A;  1YX2 A;  2FQO A;  2R7Z K;  4LLG A;  4A3E C;  3S1M K;  1YCL A;  1JOE A;  4BLB A;  3GTO K;  5IOR A;  2R92 C;  1O25 A;  3S0X A;  3H3V L;  3ORE A;  3GEE A;  1TWA K;  4M1X A;  4G7H A;  1TWG K;  1VGX A;  1DD5 A;  3N0B A;  3I4M C;  1B4B A;  4NOI A;  5IYC K;  4KC6 A;  5TJ3 A;  3V4G A;  4A3D K;  1ZYR A; 
#chains in the Genus database with same CATH homology
 1USO A;  2V6S A;  1DCP A;  2EBB A;  2V6U A;  1F93 A;  3HXA A;  1DCH A;  4C45 A;  1RU0 A;  4LOW A;  3JST A;  4WIL A;  2V6T A;  1DCO A;  1USM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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