1F93A

Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
103
structure length
103
Chain Sequence
AGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.
pubmed doi rcsb
molecule tags Transcription
source organism Rattus norvegicus
molecule keywords DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
total genus 32
structure length 103
sequence length 103
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase.
pdb deposition date 2000-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01329 Pterin_4a Pterin 4 alpha carbinolamine dehydratase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1360.20 Alpha Beta 2-Layer Sandwich Gyrase A; domain 2 Transcriptional coactivator/pterin dehydratase 1f93A00
1USOA 1USMA 4WILA 2V6SA 4C45A 1DCOA 2V6UA 3JSTA 1RU0A 1F93A 3HXAA 2V6TA 4LOWA 1DCPA 1DCHA 2EBBA
chains in the Genus database with same CATH superfamily
1YCLA 1DD5A 1ZYRA 5IOTA 5IYBC 4BKWA 4PAAA 5IORA 4YFNA 4A3JK 2NVXC 3HOUK 2GSNA 4C2MK 2PPBA 3HOZC 1ZVUA 1K83A 2PA8D 1I3QK 3A8JA 3L4JA 1SFOC 5IP9C 5TMCA 5L46A 3ADAC 3S1NK 2BE5A 1F9NA 1WORA 2JA7K 1EI6A 4OIQA 2NVQC 3GTLA 2P8TA 3T00A 3LAJA 1I6VA 4KN4A 3GTGA 4BY7C 3AH5A 3M4OC 4KATA 2XCQA 4KMHA 2A6HA 5IYDC 2JA8C 3H3VD 5JFEA 3OPFA 4AYBL 2NVTK 3FKIK 1EK8A 4M1XA 4WILA 1IE0A 4Y52C 5EGEA 4A3KK 3TTGA 3HKZD 3RZOC 5M3MK 4C3IC 4OIRA 2WAQD 5D4DA 5FJ8K 3AQPA 4G0UA 3S17C 1USMA 4C45A 1UV7A 1TWHA 3AD7C 1EFWA 4A3IK 4GT9A 5C4XK 3I4MC 4KN7A 4A3BC 1I6HC 2EBBA 3CAGA 1WQGA 4JK1A 3S15K 2GAGC 3ERED 3H0GC 1B4AA 2XCOA 2PMZL 4KARA 5C3EK 3PO3C 4LLGA 3GTQC 3GEHA 3PO2C 1JVIA 3S0XA 2A68A 4QIWD 3RZDK 5M3FK 1BDFA 4KAWX 3TFJA 2E2JC 1YX2A 1O26A 3BP8C 1O27A 1TWHK 4ILDA 3GTOA 1O2BA 4GTEA 4BXXC 3GIRA 3FOFA 2E2IA 2B63A 3M3YK 5IOSA 1TWCC 3JSTA 1VLOA 4YFKA 4MEXA 1TWAC 4YG2A 1Y1VA 4KMUA 1XZQB 3GDZA 3GTPK 3HOVC 2YU9A 3S1MK 4KASA 3S2HC 1EH1A 1X31C 4QJVB 4GFQA 3SZZA 2B63K 5TJ3A 1I50K 1I3QA 3DXJA 4C3HC 4A3DK 2JA5A 1WIHA 2FQTA 2JH3A 4C3JC 2JA6C 4BY1K 1RU0A 5IP7C 4O2DA 2KWAA 1L0WA 1O24A 1BS2A 2NVYC 4P5BA 5C4JC 3MMLB 5E68A 4GTCA 2Y0SD 1TWFC 3HOWC 5FLMK 3S16K 1WOSA 2YU9K 4A3FC 1O29A 3Q3QA 3GTJK 2CFAB 3GTKK 2ZUFA 2R7ZK 1R9TC 4A3CK 2JA5K 3FKIA 4KC6A 4A3LC 3GEIA 4MQ9A 4A3GK 3AD9C 1K83C 2R92K 1WOPA 5CJ9A 4Y7NK 1KQ4A 3GTMK 1XZPB 1GE9A 2VUMC 4FM9A 4FZBA 3G4CA 3GTLC 5IYCC 4OINA 3S1RC 3GTGC 3LPXA 4A93C 4GZYA 5IYBK 1PJ6A 2GSUA 2W7VA 1C0AA 2NVXK 4XLNA 4P9SA 4ZH4A 2CW0A 3HOZK 1VGXA 1B4BA 1HI9A 3IPJA 1TWGC 1R9TK 1SFOK 5IP9K 4BBSC 3BP3A 1PJ5A 4G0VA 1BGWA 2NVQK 5HL8A 3S2DC 4BY7K 3LAPA 4G7HA 3M4OK 2PA8L 2Y3PA 3CQZC 4KDDA 5IYDK 2ZFZA 3S1RK 2JA8K 4Q4ZA 3A8KA 2E2HC 4KM8A 3G4AA 3GTQA 4A3EC 3GTPA 4Y52K 3N0BA 4XSZA 3S14C 3RZOK 3N3YA 4XCHA 4C3IK 4P5AA 3GEEA 1XXAA 2D6FC 3SZYA 1I50A 3H3VL 1F7UA 3S1QC 4A3MC 3S17K 2V6UA 3GTOC 3EQLA 3I4MK 4A3BK 1WCMC 1I6HK 4X6AC 2E2IC 3HOXC 1BJTA 4BBRC 3HKZL 2RGRA 2R93C 3H0GK 2WAQL 3PO3K 3GTQK 3PO2K 1YNJA 1Y1WC 3I4NC 4RMFA 4OIOA 3TFHA 3VA7A 4PABA 3GTJA 2E2JK 3GTKA 1ISEA 2R7ZA 4A3JC 2RH6A 1XPPA 3A8IA 1JQWA 1EQRA 2R92A 2FQOA 4BXXK 4KMAA 3S1NC 3GTMA 3L4KA 4NOIA 1TWCK 2JA7C 1WCMK 4LOWA 1F7VA 1G51A 1TWAK 1F93A 3T01A 4AYBD 3BUEA 2NVYA 4WJ3M 5C44C 1DCPA 1TWFA 3OEPA 3HOVK 1V5VA 1ZXOA 2NVXA 3S2HK 1HQMA 2WB1L 2PHCB 4G7OA 2NVTC 3FKIC 5M5WK 1R9TA 4C3HK 1SFOA 1IL2A 2JA6K 4C3JK 4A3KC 1J98A 5IP7K 3GSIA 2NVYK 3V4GA 2PMZD 5C4JK 3FOEA 2GAHC 4KMDA 4MEYA 5EGHA 4BLAA 4G7ZA 1TWFK 3HOWK 1WSVA 1ZQ1C 2VUMA 1DCOA 4A3IC 5C4XC 2A69A 4A3FK 1WOOA 1YNNA 3S15C 3AD8C 4KM9A 1SMYA 1IBAA 5C44K 5CHPA 4DDQA 5C3EC 4A3LK 1O25A 2A6EA 2Y0SL 4LQYA 3RZDC 3HOYC 4XSXA 1XZQA 2XCRB 1K83K 3HXAA 1TWGA 4GTLA 1IS1A 2O5IA 3K7AC 4LK0A 1VJEA 1VRQC 1TWHC 2VUMK 3WODA 3QX3A 4QJVA 3GTLK 5IYCK 4LR2A 1AB4A 3GTGK 1JOEA 4G0WA 4A93K 3M3YC 1O2FB 4J3NA 3H0GA 3OREA 2P5MA 3CQZA 5M5YK 1IQ0A 4LK1A 3AQOA 1IW7A 3NUHA 1WQFA 1J6XA 1TWGK 1PJ7A 2E2HA 3GTPC 4XLPA 2CFAA 4BLBA 3S1MC 4BBSK 1WSRA 3T02A 4OIPA 3HOYK 2V6TA 1VH2A 3TFIA 2B63C 1I50C 3S2DK 3K7AK 4A3DC 4BY1C 3CQZK 1TWCA 1INNA 1Y1VC 1DCHA 1J6WA 1WCMA 1O28A 1XZPA 1TWAA 5JVOA 2E2HK 1O2AA 2R93A 5FLMC 3S16C 4Q5SA 2WB1D 2YU9C 4GTDA 3HOUC 4A3EK 1Y1WA 4KB4A 4C2MC 3GTJC 3S14K 3GTKC 2V6SA 4AH6A 4QIWL 2R7ZC 5IOQA 1I3QC 5TMFA 1ZBSA 4A3CC 2JA5C 3S1QK 4GTBA 4A3MK 4GTFA 2JA6A 4YFXA 3GTOK 1J6VA 4A3GC 2R92C 4X6AK 1USOA 3N0CA 4KB2A 2E2IK 3HOXK 3FHZA 4BBRK 1WQHA 4Y7NC 1XXCA 4WJ4A 3GTMC 2R93K 4GTAA 1XXBA 3I4NK 1Y1WK 2ZUEA 5M5XK 2JA7A 1Y1VK 4LJZA 2O5JA 2GSOA
chains in the Genus database with same CATH topology
1USOA 1USMA 4WILA 2V6SA 4C45A 1DCOA 2V6UA 3JSTA 1RU0A 1F93A 3HXAA 2V6TA 4LOWA 1DCPA 1DCHA 2EBBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1USO A;  1USM A;  4WIL A;  2V6S A;  4C45 A;  1DCO A;  2V6U A;  3JST A;  1RU0 A;  1F93 A;  3HXA A;  2V6T A;  4LOW A;  1DCP A;  1DCH A;  2EBB A; 
#chains in the Genus database with same CATH topology
 1YCL A;  1DD5 A;  1ZYR A;  5IOT A;  5IYB C;  4BKW A;  4PAA A;  5IOR A;  4YFN A;  4A3J K;  2NVX C;  3HOU K;  2GSN A;  4C2M K;  2PPB A;  3HOZ C;  1ZVU A;  1K83 A;  2PA8 D;  1I3Q K;  3A8J A;  3L4J A;  1SFO C;  5IP9 C;  5TMC A;  5L46 A;  3ADA C;  3S1N K;  2BE5 A;  1F9N A;  1WOR A;  2JA7 K;  1EI6 A;  4OIQ A;  2NVQ C;  3GTL A;  2P8T A;  3T00 A;  3LAJ A;  1I6V A;  4KN4 A;  3GTG A;  4BY7 C;  3AH5 A;  3M4O C;  4KAT A;  2XCQ A;  4KMH A;  2A6H A;  5IYD C;  2JA8 C;  3H3V D;  5JFE A;  3OPF A;  4AYB L;  2NVT K;  3FKI K;  1EK8 A;  4M1X A;  4WIL A;  1IE0 A;  4Y52 C;  5EGE A;  4A3K K;  3TTG A;  3HKZ D;  3RZO C;  5M3M K;  4C3I C;  4OIR A;  2WAQ D;  5D4D A;  5FJ8 K;  3AQP A;  4G0U A;  3S17 C;  1USM A;  4C45 A;  1UV7 A;  1TWH A;  3AD7 C;  1EFW A;  4A3I K;  4GT9 A;  5C4X K;  3I4M C;  4KN7 A;  4A3B C;  1I6H C;  2EBB A;  3CAG A;  1WQG A;  4JK1 A;  3S15 K;  2GAG C;  3ERE D;  3H0G C;  1B4A A;  2XCO A;  2PMZ L;  4KAR A;  5C3E K;  3PO3 C;  4LLG A;  3GTQ C;  3GEH A;  3PO2 C;  1JVI A;  3S0X A;  2A68 A;  4QIW D;  3RZD K;  5M3F K;  1BDF A;  4KAW X;  3TFJ A;  2E2J C;  1YX2 A;  1O26 A;  3BP8 C;  1O27 A;  1TWH K;  4ILD A;  3GTO A;  1O2B A;  4GTE A;  4BXX C;  3GIR A;  3FOF A;  2E2I A;  2B63 A;  3M3Y K;  5IOS A;  1TWC C;  3JST A;  1VLO A;  4YFK A;  4MEX A;  1TWA C;  4YG2 A;  1Y1V A;  4KMU A;  1XZQ B;  3GDZ A;  3GTP K;  3HOV C;  2YU9 A;  3S1M K;  4KAS A;  3S2H C;  1EH1 A;  1X31 C;  4QJV B;  4GFQ A;  3SZZ A;  2B63 K;  5TJ3 A;  1I50 K;  1I3Q A;  3DXJ A;  4C3H C;  4A3D K;  2JA5 A;  1WIH A;  2FQT A;  2JH3 A;  4C3J C;  2JA6 C;  4BY1 K;  1RU0 A;  5IP7 C;  4O2D A;  2KWA A;  1L0W A;  1O24 A;  1BS2 A;  2NVY C;  4P5B A;  5C4J C;  3MML B;  5E68 A;  4GTC A;  2Y0S D;  1TWF C;  3HOW C;  5FLM K;  3S16 K;  1WOS A;  2YU9 K;  4A3F C;  1O29 A;  3Q3Q A;  3GTJ K;  2CFA B;  3GTK K;  2ZUF A;  2R7Z K;  1R9T C;  4A3C K;  2JA5 K;  3FKI A;  4KC6 A;  4A3L C;  3GEI A;  4MQ9 A;  4A3G K;  3AD9 C;  1K83 C;  2R92 K;  1WOP A;  5CJ9 A;  4Y7N K;  1KQ4 A;  3GTM K;  1XZP B;  1GE9 A;  2VUM C;  4FM9 A;  4FZB A;  3G4C A;  3GTL C;  5IYC C;  4OIN A;  3S1R C;  3GTG C;  3LPX A;  4A93 C;  4GZY A;  5IYB K;  1PJ6 A;  2GSU A;  2W7V A;  1C0A A;  2NVX K;  4XLN A;  4P9S A;  4ZH4 A;  2CW0 A;  3HOZ K;  1VGX A;  1B4B A;  1HI9 A;  3IPJ A;  1TWG C;  1R9T K;  1SFO K;  5IP9 K;  4BBS C;  3BP3 A;  1PJ5 A;  4G0V A;  1BGW A;  2NVQ K;  5HL8 A;  3S2D C;  4BY7 K;  3LAP A;  4G7H A;  3M4O K;  2PA8 L;  2Y3P A;  3CQZ C;  4KDD A;  5IYD K;  2ZFZ A;  3S1R K;  2JA8 K;  4Q4Z A;  3A8K A;  2E2H C;  4KM8 A;  3G4A A;  3GTQ A;  4A3E C;  3GTP A;  4Y52 K;  3N0B A;  4XSZ A;  3S14 C;  3RZO K;  3N3Y A;  4XCH A;  4C3I K;  4P5A A;  3GEE A;  1XXA A;  2D6F C;  3SZY A;  1I50 A;  3H3V L;  1F7U A;  3S1Q C;  4A3M C;  3S17 K;  2V6U A;  3GTO C;  3EQL A;  3I4M K;  4A3B K;  1WCM C;  1I6H K;  4X6A C;  2E2I C;  3HOX C;  1BJT A;  4BBR C;  3HKZ L;  2RGR A;  2R93 C;  3H0G K;  2WAQ L;  3PO3 K;  3GTQ K;  3PO2 K;  1YNJ A;  1Y1W C;  3I4N C;  4RMF A;  4OIO A;  3TFH A;  3VA7 A;  4PAB A;  3GTJ A;  2E2J K;  3GTK A;  1ISE A;  2R7Z A;  4A3J C;  2RH6 A;  1XPP A;  3A8I A;  1JQW A;  1EQR A;  2R92 A;  2FQO A;  4BXX K;  4KMA A;  3S1N C;  3GTM A;  3L4K A;  4NOI A;  1TWC K;  2JA7 C;  1WCM K;  4LOW A;  1F7V A;  1G51 A;  1TWA K;  1F93 A;  3T01 A;  4AYB D;  3BUE A;  2NVY A;  4WJ3 M;  5C44 C;  1DCP A;  1TWF A;  3OEP A;  3HOV K;  1V5V A;  1ZXO A;  2NVX A;  3S2H K;  1HQM A;  2WB1 L;  2PHC B;  4G7O A;  2NVT C;  3FKI C;  5M5W K;  1R9T A;  4C3H K;  1SFO A;  1IL2 A;  2JA6 K;  4C3J K;  4A3K C;  1J98 A;  5IP7 K;  3GSI A;  2NVY K;  3V4G A;  2PMZ D;  5C4J K;  3FOE A;  2GAH C;  4KMD A;  4MEY A;  5EGH A;  4BLA A;  4G7Z A;  1TWF K;  3HOW K;  1WSV A;  1ZQ1 C;  2VUM A;  1DCO A;  4A3I C;  5C4X C;  2A69 A;  4A3F K;  1WOO A;  1YNN A;  3S15 C;  3AD8 C;  4KM9 A;  1SMY A;  1IBA A;  5C44 K;  5CHP A;  4DDQ A;  5C3E C;  4A3L K;  1O25 A;  2A6E A;  2Y0S L;  4LQY A;  3RZD C;  3HOY C;  4XSX A;  1XZQ A;  2XCR B;  1K83 K;  3HXA A;  1TWG A;  4GTL A;  1IS1 A;  2O5I A;  3K7A C;  4LK0 A;  1VJE A;  1VRQ C;  1TWH C;  2VUM K;  3WOD A;  3QX3 A;  4QJV A;  3GTL K;  5IYC K;  4LR2 A;  1AB4 A;  3GTG K;  1JOE A;  4G0W A;  4A93 K;  3M3Y C;  1O2F B;  4J3N A;  3H0G A;  3ORE A;  2P5M A;  3CQZ A;  5M5Y K;  1IQ0 A;  4LK1 A;  3AQO A;  1IW7 A;  3NUH A;  1WQF A;  1J6X A;  1TWG K;  1PJ7 A;  2E2H A;  3GTP C;  4XLP A;  2CFA A;  4BLB A;  3S1M C;  4BBS K;  1WSR A;  3T02 A;  4OIP A;  3HOY K;  2V6T A;  1VH2 A;  3TFI A;  2B63 C;  1I50 C;  3S2D K;  3K7A K;  4A3D C;  4BY1 C;  3CQZ K;  1TWC A;  1INN A;  1Y1V C;  1DCH A;  1J6W A;  1WCM A;  1O28 A;  1XZP A;  1TWA A;  5JVO A;  2E2H K;  1O2A A;  2R93 A;  5FLM C;  3S16 C;  4Q5S A;  2WB1 D;  2YU9 C;  4GTD A;  3HOU C;  4A3E K;  1Y1W A;  4KB4 A;  4C2M C;  3GTJ C;  3S14 K;  3GTK C;  2V6S A;  4AH6 A;  4QIW L;  2R7Z C;  5IOQ A;  1I3Q C;  5TMF A;  1ZBS A;  4A3C C;  2JA5 C;  3S1Q K;  4GTB A;  4A3M K;  4GTF A;  2JA6 A;  4YFX A;  3GTO K;  1J6V A;  4A3G C;  2R92 C;  4X6A K;  1USO A;  3N0C A;  4KB2 A;  2E2I K;  3HOX K;  3FHZ A;  4BBR K;  1WQH A;  4Y7N C;  1XXC A;  4WJ4 A;  3GTM C;  2R93 K;  4GTA A;  1XXB A;  3I4N K;  1Y1W K;  2ZUE A;  5M5X K;  2JA7 A;  1Y1V K;  4LJZ A;  2O5J A;  2GSO A; 
#chains in the Genus database with same CATH homology
 1USO A;  1USM A;  4WIL A;  2V6S A;  4C45 A;  1DCO A;  2V6U A;  3JST A;  1RU0 A;  1F93 A;  3HXA A;  2V6T A;  4LOW A;  1DCP A;  1DCH A;  2EBB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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