The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
183
|
sequence length |
713
|
structure length |
685
|
Chain Sequence |
DRALPFIGDGLKPVQRRIVYAMSELGLRTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSAREPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEID
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The Structural Basis for Substrate Specificity in DNA Topoisomerase IV.
pubmed doi rcsb |
| molecule keywords |
Topoisomerase IV subunit A
|
| molecule tags |
Isomerase
|
| source organism |
Escherichia coli
|
| total genus |
183
|
| structure length |
685
|
| sequence length |
713
|
| ec nomenclature |
ec
5.99.1.-: |
| pdb deposition date | 2005-06-02 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00521 | DNA_topoisoIV | DNA gyrase/topoisomerase IV, subunit A |
| A | PF03989 | DNA_gyraseA_C | DNA gyrase C-terminal domain, beta-propeller |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Topoisomerase; domain 3 | Topoisomerase, domain 3 | ||
| Alpha Beta | 2-Layer Sandwich | Gyrase A; domain 2 | Gyrase A; domain 2 | ||
| Alpha Beta | Alpha-Beta Complex | Topoisomerase II; domain 5 | Topoisomerase II, domain 5 |
#chains in the Genus database with same CATH superfamily 4KDD A; 3FHZ A; 2XCR B; 4TMA A; 4KB4 A; 1BJT A; 2RGR A; 2XCO A; 3NUH A; 1XXB A; 1B4A A; 4G0V A; 1DD5 A; 3MML B; 4J3N A; 2ZFZ A; 5CJ9 A; 4G0U A; 3FOF A; 3CAG A; 1GE9 A; 3FOE A; 4GFQ A; 3LAP A; 1EK8 A; 1XXC A; 5JVO A; 4Z3O A; 4CKK A; 4KC6 A; 3L4J A; 1X75 A; 1ZVU A; 1WQG A; 3LPX A; 4ELY A; 3OPF A; 4CKL A; 4KB2 A; 2XCQ A; 4DDQ A; 1IS1 A; 2KWA A; 3LAJ A; 1EH1 A; 4KAW X; 3VA7 A; 4FM9 A; 3QX3 A; 1F9N A; 1XXA A; 3ORE A; 3ERE D; 1WQH A; 4Z4Q A; 4G0W A; 1BGW A; 1B4B A; 1AB4 A; 1ISE A; 2P5M A; 3BUE A; 1WQF A; 3V4G A; 4Z53 A; 1WIH A; 2Y3P A; 4ELZ A; 3OEP A; 3L4K A; 2PHC B; #chains in the Genus database with same CATH topology 4KDD A; 4LLG A; 1XZQ A; 2E2I K; 2NVY A; 3HOU K; 4BY1 K; 4A93 C; 5C4X C; 1WCM C; 3S2D K; 3S1Q C; 3T02 A; 4C3H K; 4YG2 A; 1I50 K; 5IYB C; 2Y0S L; 5EGE A; 3S1M K; 2A6E A; 4C3I K; 3AQO A; 2YU9 A; 3TFI A; 2WB1 D; 1IS1 A; 3H3V D; 3JST A; 3I4N K; 2WAQ D; 1WQF A; 1I3Q K; 1VJE A; 4KC6 A; 3GTM C; 5M3M K; 5FJ8 K; 3Q3Q A; 4AH6 A; 2FQO A; 1VGX A; 1XXB A; 4OIQ A; 4XCH A; 3HOX K; 1PJ5 A; 1R9T C; 3S14 C; 4BLB A; 4G7Z A; 2FQT A; 3I4M K; 1F7U A; 4QIW L; 1Y1V K; 4A3M C; 1TWH C; 2PMZ L; 5JFE A; 2JA6 A; 1XXA A; 3ERE D; 1L0W A; 3HOV C; 3GTQ A; 1C0A A; 4P5B A; 4A3L K; 1O26 A; 3GTL C; 2A68 A; 3HOY K; 1TWA K; 1TWG C; 1K83 A; 3FKI K; 2JA7 A; 4QJV B; 3S2H K; 2GSU A; 2CFA B; 4A3J C; 4C3J C; 5FLM K; 2R92 C; 2R93 K; 4WJ3 M; 1HI9 A; 1I50 C; 3GSI A; 3AD8 C; 4CKL A; 4GTC A; 3LAJ A; 3A8K A; 3CQZ A; 4A93 K; 1O25 A; 5C4X K; 5IOR A; 1SFO A; 3S1Q K; 5IYB K; 3EQL A; 1TWF A; 4LQY A; 2P8T A; 4GTF A; 1F93 A; 3T01 A; 4J3N A; 1DCO A; 4AYB L; 1F7V A; 5EGH A; 2W7V A; 2GSN A; 2E2J C; 1UV7 A; 4XLP A; 4CID A; 4ELY A; 3WOD A; 2Y0S D; 4KB2 A; 4GTD A; 4XSZ A; 1YNN A; 2A6H A; 3GTO C; 2RH6 A; 3I4M C; 3GTM K; 4MQ9 A; 3GEI A; 4ZH4 A; 4LK1 A; 3GTK A; 1R9T K; 3S14 K; 1O2A A; 1I3Q A; 4YFK A; 3HKZ L; 1DD5 A; 3GTG C; 5IP9 C; 3ADA C; 2PA8 D; 4OIR A; 2A69 A; 1TWH K; 3GTJ C; 3OPF A; 4G7H A; 3HOV K; 1SMY A; 2ZUF A; 1JOE A; 2R7Z A; 5M5W K; 3GTL K; 1F9N A; 1ZXO A; 2B63 C; 4BY7 C; 2NVX A; 1TWG K; 4KAR A; 4A3F C; 1PJ6 A; 2NVY C; 3HOZ C; 1BS2 A; 1WOR A; 2XCO A; 4G0V A; 4A3J K; 2E2H A; 4C3J K; 2R92 K; 3TFH A; 1EK8 A; 5TMF A; 1WOO A; 1PJ7 A; 4A3G C; 4O2D A; 3G4C A; 1O2B A; 4KM8 A; 2R93 A; 4P9S A; 2VUM A; 5IOT A; 3BUE A; 1ISE A; 5C44 C; 1J98 A; 4MEX A; 3RZO C; 1BJT A; 1WCM A; 3NUH A; 5HL8 A; 2E2J K; 3PO3 C; 4A3E C; 2NVT C; 4AYB D; 1VLO A; 3GTO K; 4BXX C; 4DDQ A; 2JA6 C; 3PO2 C; 1ZBS A; 3GTQ C; 4G0W A; 3AD7 C; 3S17 K; 3LPX A; 3TTG A; 5C3E C; 1EFW A; 4BLA A; 2JA7 C; 3GTG K; 5IP9 K; 4GZY A; 1TWC A; 4A3K C; 3HOW C; 1GE9 A; 1R9T A; 3GTJ K; 4A3C C; 4KMA A; 4JK1 A; 3S0X A; 2B63 K; 4BY7 K; 1Y1W A; 4LOW A; 4A3F K; 1J6V A; 5CHP A; 3GTP A; 1RU0 A; 4GTB A; 2JA5 C; 1BGW A; 1IW7 A; 2NVY K; 3CQZ C; 3N0C A; 3V4G A; 1O29 A; 3HOZ K; 1SFO C; 4RMF A; 3OEP A; 3AQP A; 1TWF C; 4KN7 A; 4X6A C; 4A3G K; 2ZFZ A; 5L46 A; 2YU9 K; 2WB1 L; 2E2I A; 1G51 A; 1WSR A; 1ZVU A; 1I50 A; 5M3F K; 4KMU A; 1O28 A; 4KAT A; 4C2M C; 5M5Y K; 3VA7 A; 4XSX A; 3QX3 A; 1USM A; 1JVI A; 1WQH A; 4LJZ A; 5C44 K; 1WOP A; 2O5I A; 3RZO K; 3SZY A; 4BBR C; 1J6W A; 4BBS C; 4Y52 C; 5IYC C; 3GTK C; 2RGR A; 4A3D C; 1INN A; 2XCR B; 4KB4 A; 3PO3 K; 4A3E K; 3GDZ A; 3S17 C; 2NVT K; 4OIN A; 3N3Y A; 4NOI A; 3N0B A; 4BXX K; 4LK0 A; 2JA6 K; 1WQG A; 3PO2 K; 3GTQ K; 5D4D A; 2QPT A; 2R7Z C; 1DCP A; 4KM9 A; 4Z4Q A; 3M4O C; 2JA7 K; 5C3E K; 2P5M A; 3H0G C; 4A3K K; 1Y1V A; 4QIW D; 3HOW K; 2PMZ D; 2JA8 C; 4TMA A; 3M3Y C; 1YX2 A; 5IP7 C; 4YFX A; 2E2H C; 1IE0 A; 4LR2 A; 4BKW A; 4A3C K; 4G0U A; 4MEY A; 1TWA A; 4Y7N C; 3FKI A; 3GEH A; 1XXC A; 1KQ4 A; 2YU9 C; 4G7O A; 3SZZ A; 1V5V A; 3CQZ K; 2JA5 K; 2VUM C; 1O27 A; 1SFO K; 1DCH A; 3S15 C; 1TWF K; 4P5A A; 3A8J A; 4PAB A; 1IBA A; 4X6A K; 4GTA A; 3L4K A; 2GSO A; 4GTE A; 3FHZ A; 3S1R K; 1XZP A; 3RZD C; 1YCL A; 3DXJ A; 3K7A C; 4A3B C; 4Q5S A; 2JH3 A; 4KN4 A; 4C2M K; 2ZUE A; 4BBR K; 2V6T A; 4GTL A; 1VRQ C; 1J6X A; 4BBS K; 4Y52 K; 5IYC K; 3GTK K; 1B4B A; 4A3D K; 3BP3 A; 4OIO A; 4KAS A; 3S1N C; 2Y3P A; 3S16 C; 2PA8 L; 4WIL A; 1TWC C; 1K83 C; 2PPB A; 3GTM A; 4PAA A; 3MML B; 4A3I C; 3IPJ A; 3LAP A; 1WSV A; 4OIP A; 1IQ0 A; 2R7Z K; 2D6F C; 5IYD C; 5TMC A; 3HKZ D; 1Y1W C; 3AH5 A; 2NVX K; 3BP8 C; 1HQM A; 5C4J K; 2XCQ A; 2V6U A; 3M4O K; 1EQR A; 2KWA A; 3GTP C; 3H0G K; 1I6H C; 3AD9 C; 3ORE A; 1TWH A; 1I6V A; 1AB4 A; 2JA8 K; 3M3Y K; 5IP7 K; 5E68 A; 4Q4Z A; 3GTL A; 2E2H K; 2EBB A; 1WIH A; 3GEE A; 1TWG A; 4Y7N K; 4WJ4 A; 5CJ9 A; 1B4A A; 5TJ3 A; 2NVQ C; 3HOU C; 2E2I C; 1EI6 A; 4BY1 C; 4GT9 A; 1O24 A; 3S1R C; 5JVO A; 3S2D C; 3TFJ A; 4C3H C; 2VUM K; 3H3V L; 3L4J A; 4KMD A; 2R92 A; 2WAQ L; 3S1M C; 4C3I C; 3S15 K; 4KAW X; 5M5X K; 4FM9 A; 2GAG C; 2JA5 A; 3T00 A; 1WCM K; 4Z53 A; 2BE5 A; 4YFN A; 3I4N C; 2V6S A; 4FZB A; 3RZD K; 1X31 C; 3K7A K; 4A3B K; 2O5J A; 1JQW A; 1I3Q C; 1VH2 A; 3FOF A; 3CAG A; 4XLN A; 5IOS A; 4GFQ A; 1IL2 A; 1XZQ B; 4Z3O A; 3HOX C; 3GIR A; 1X75 A; 1XZP B; 1EH1 A; 4QJV A; 3S1N K; 3GTO A; 2NVX C; 3S16 K; 1TWC K; 1K83 K; 5C4J C; 1Y1V C; 1XPP A; 4KMH A; 3G4A A; 2CFA A; 2GAH C; 4A3I K; 4A3L C; 1ZQ1 C; 3HOY C; 1TWA C; 5IYD K; 3FKI C; 1WOS A; 3FOE A; 1O2F B; 3GTG A; 1Y1W K; 3A8I A; 3S2H C; 4CKK A; 1BDF A; 4A3M K; 4ILD A; 3HXA A; 3GTP K; 1I6H K; 4C45 A; 1USO A; 3GTJ A; 5FLM C; 2R93 C; 4M1X A; 2CW0 A; 1ZYR A; 2B63 A; 3H0G A; 1YNJ A; 5IOQ A; 4ELZ A; 2NVQ K; 2PHC B; #chains in the Genus database with same CATH homology 4KDD A; 2NVY A; 3GTM A; 1O2A A; 1I3Q A; 1DD5 A; 3MML B; 2ZFZ A; 3LAP A; 2E2I A; 5EGE A; 3AQO A; 2YU9 A; 1ZVU A; 1I50 A; 1O28 A; 3AH5 A; 3OPF A; 2XCQ A; 4KAT A; 2R7Z A; 1IS1 A; 2KWA A; 4C2M C; 3VA7 A; 3QX3 A; 3ORE A; 1F9N A; 1ZXO A; 1TWH A; 1WQH A; 2NVX A; 1AB4 A; 4KAR A; 1WQF A; 3GTL A; 1WIH A; 2RGR A; 4KC6 A; 3Q3Q A; 2XCR B; 1TWG A; 4KB4 A; 2XCO A; 1XXB A; 5CJ9 A; 1B4A A; 4G0V A; 5TJ3 A; 2E2H A; 3N3Y A; 4BLB A; 1EK8 A; 4GT9 A; 1O24 A; 5JVO A; 4C3H C; 3N0B A; 3L4J A; 4KMD A; 2R92 A; 1WQG A; 3G4C A; 1O2B A; 4C3I C; 4KM8 A; 2R93 A; 2VUM A; 4KM9 A; 4KAW X; 4FM9 A; 5IOT A; 5JFE A; 1XXA A; 3ERE D; 2JA6 A; 3GTQ A; 4Z4Q A; 2JA5 A; 3BUE A; 1ISE A; 2P5M A; 4P5B A; 1O26 A; 1Y1V A; 4Z53 A; 4FZB A; 1K83 A; 4TMA A; 2JA7 A; 1BJT A; 1WCM A; 3NUH A; 4LR2 A; 4BKW A; 4G0U A; 3FOF A; 2GSU A; 3CAG A; 5IOS A; 2CFA B; 1TWA A; 4GFQ A; 3FKI A; 1XXC A; 4Z3O A; 4C3J C; 1KQ4 A; 1X75 A; 4CKL A; 4DDQ A; 4GTC A; 1O27 A; 3LAJ A; 1EH1 A; 1ZBS A; 3GTO A; 4G0W A; 3CQZ A; 4P5A A; 1O25 A; 3G4A A; 4KMH A; 2CFA A; 5IOR A; 1SFO A; 3LPX A; 4GTA A; 2GSO A; 3L4K A; 4GTE A; 3FHZ A; 4BLA A; 3GTK A; 4LQY A; 1TWF A; 1TWC A; 4GTF A; 4J3N A; 1GE9 A; 1R9T A; 3FOE A; 2JH3 A; 3GTG A; 5EGH A; 2GSN A; 4CKK A; 4KMA A; 3S0X A; 4ILD A; 4ELY A; 3GTJ A; 4KB2 A; 4GTD A; 1Y1W A; 3OEP A; 4M1X A; 5CHP A; 4GTL A; 3GTP A; 2RH6 A; 4GTB A; 1BGW A; 1B4B A; 2B63 A; 3N0C A; 3V4G A; 1O29 A; 3H0G A; 4KAS A; 5IOQ A; 2Y3P A; 4ELZ A; 3AQP A; 2PHC B;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
