2J7QA

Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein m48 in complex with a ubquitin-based suicide substrate
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
232
structure length
232
Chain Sequence
MKIVRASRDQSAPVYGPRAGSQCMSNCFTFLHTCYLMGIDPVLDTTSLDAVLDSGARLDAIADEKVKRQALTDHPYRLGTEIPTVIETPAGITGHALSRPFNGTAETQDLGGYKCLGILDFLTYARGKPLPVYIIVTVGVHTRGVIVARGATYVFDPHTTDLSAEAAVYVCDDFTEAISALSFFTEMIGDFYYDAVLVYFTRCRTTLISPSELLVQIMDQYKDPDIDASVMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
pubmed doi rcsb
molecule tags Hydrolase
source organism Murine cytomegalovirus
molecule keywords MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEA
total genus 69
structure length 232
sequence length 232
ec nomenclature
pdb deposition date 2006-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.120 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2j7qA00
2J7QC 2J7QA
chains in the Genus database with same CATH superfamily
3LXSA 3V6CA 1ME3A 4N4ZA 1NLJA 4K7CA 4MSXA 5F02A 3IEJA 1BGOA 1VSNA 3ERVA 1AU0A 1KHPA 1PE6A 3HD3A 3I3TA 4YYUA 1QDQA 2PADA 1PPPA 4BS6A 5FPWA 3MTVA 3F75A 1ITOA 2BTWA 4KLBA 4WURA 4BPVA 2DCCA 2UZJA 2ATOA 3ZNHA 2GHUA 2E03A 2YJ8A 4CDEB 1VJVA 1EWOA 1U9VA 3IHPA 1PPNA 4QRGA 4REZA 4I05A 5PADA 5CHVA 1AYUA 1F29A 2NQGA 3RNVA 3P5VA 3OF9A 3PRPA 1GCBA 3PHWA 1NB5A 3NHEA 4YYSA 1AYVA 3LFYA 1YALA 4MM3B 3KX1A 1U9XA 2AVWA 5EZSA 1NQCA 5K16A 2NQIA 1QXPA 3BCNA 2F7DA 3IMAA 5CVNB 2ARYA 2P7UA 3M99A 2BDLA 3O0UA 3PSEA 1PPOA 3E9SA 3P5XA 5A24A 4I04A 1YZBA 2XU4A 4CDCB 3P5WA 3N3GA 1X9YA 1MIRA 2B1NA 1EWLA 2FQ9A 2AIMA 3BC3A 1CVZA 1HUCB 4BOSA 2AGAA 2DC9A 3K24A 4P6GA 2YJBA 1CTEA 4R3DA 4YVAA 4PADA 1QMYA 2PREA 4YYWA 1KHQA 3CBKA 9PAPA 4BSQA 1THEA 3V6EA 3MP2A 3O1GA 3D6SA 1PCIA 4M0WA 1GECE 4P16A 4CDDB 1ATKA 1Q6KA 2FYEA 1KXRA 4MZOA 1CPJA 3QSDA 3OISA 4ZUXU 1KFXL 2OZ2A 3H8BA 2R9FA 1JQPA 2FT2A 2H7JA 2DC7A 2WBFX 4ZTBA 2JTCA 1F2CA 3IOQA 3C9EA 5JA7A 2FUDA 1EWPA 2IPPB 1U5IA 1EF7A 2R9CA 1BQIA 3CH3X 4OVZA 4AXLA 3PDFA 2E01A 2OP3A 1CJLA 1SP4B 3N4CA 1DEUA 3KW9A 3RVWA 3H8CA 2R6NA 2C0YA 2DC6A 2AYOA 1YT7A 3MORA 4XR7A 4N79A 3W31A 1XKGA 3BB7A 2AUZA 2DJFB 4PI3A 4N8WA 4BQVA 4MI7A 2AUXA 3HHAA 3B21A 2FRQA 3H6SA 2R9OA 3I06A 2HD5A 2HWKA 4D8BA 3OVZA 1CQDA 3RVVA 3IUTA 3OQCA 3IV2A 3QJ3A 1KFUL 2HHNA 2O6XA 4PP1A 3KFQA 3WXGA 5EF4A 4I07A 4RF0A 2YJ2A 1AU2A 2JQGR 3IFUA 8PCHA 1TL9A 2P0RA 3O65A 4QRVA 3P5UA 2J7QA 1FH0A 4FK5A 5JH3A 1A6RA 3H89A 3MHHA 4FIPA 1CV8A 5CVMA 4W5CA 5JZEA 4OVZB 2BDZA 1MDWA 4X6IA 3KSEA 1NPZA 3TNXA 4IP3A 4QRXA 2JQFR 2DC8A 3OF8A 4BOUA 3MTNA 7PCKA 4YYQA 2E00A 3BPMA 6PADA 4DMXA 3KWBX 3PHUA 3KKUA 1PVJA 2YJ9A 1PPDA 1CS8A 4W4UA 1AU3A 2G8EA 1UKFA 1Y08A 4IUMA 1AIMA 2ACTA 1U9QX 3WXFA 2OULA 3USVA 4BS5A 4X6HA 3HHIA 1SNKA 5EZQA 2DOSA 2PNSA 4YYRA 4BOZA 1PIPA 3B79A 4PT5A 2VHFA 1QOLA 2FE8A 2FTDA 1PADA 2Z84A 1PXVA 1Y4HA 3PBHA 4XUIA 4HXDB 2VHSA 2XU1A 4BOPA 2HXZA 2CIOA 3BOWA 4A5UA 4OEMA 5J94A 3WXEA 1MEMA 1O0EA 1EWMA 2BU3A 4X6JA 1F2AA 4D8EA 1S4VA 1YVBA 1GLOA 4P6EA 2B1MA 4RF1A 5KO3A 1K3BB 2FRAA 3E1ZB 3DF0A 4YYVA 3F5VA 3BY4A 2R9MA 1DF0A 3H7DA 1TU6A 1F2BA 2J7QC 2CB5A 2Y5BA 3TMPA 2R9NA 4OELA 1POPA 2DCBA 2NQDB 3MJ5A 1MHWA 2NQAA 2IBIA 1ME4A 4QH6A 2HH5A 4XZXA 4CZWA 1GMYA 2G7YA 3CH2X 2JRIA 4AXMA 2PBHA 4RNAA 3OVXA 4D8IA 4MZSA 2E02A 2G8JA 1YK8A 1ZIVA 1AU4A 1BP4A 4OW0A 1M6DA 4WA6A 5EGWA 3W30A 1ICFA 3K9MA 4Q8GA 1CB5A 4PP2E 2AS8A 1TLOA 4GUAA 4RY2A 3GCBA 2DZZA 2FO5A 3HWNA 3BWKA 4QBBA 2DCAA 1STFE 1DKIA 2GFOA 4CDFB 3TRKA 2P86A 4YV8A 2XU5A 5E6JA 3K8UA 2DZYA 2YJCA 2DCDA 1MS6A 3BPFA 2F1GA 4G54A 2BTWB 3PHXA 3S3QA 4Q8HA 3PW3A 5CVOB 1AECA 4DMYA 3RVXA 3AI8A 3MHSA 4HWYA 1U9WA 3U8EA 2G6DA 4RKXA 2AYNA 2Y6EA 1AYWA 1YK7A 3PT2A 1NL6A 3KWZA 3C0RA 2XU3A 1BY8A 3PNRA 1NB3A 3N3KA 2AU1A 1CSBB 1ZCMA 3CBJA 4BOQA 3PRMA 3QT4A 5CHTA 1IWDA 1MEGA 4W5BA 3ZUAA 2DJGB 4FJCA 1PBHA 3S3RA 3BBAA
chains in the Genus database with same CATH topology
4M0WA 4P16A 5JZEA 4OVZB 2J7QC 3TMPA 4IP3A 3MJ5A 4ZTBA 2JTCA 3MTVA 4XZXA 4BOUA 2BTWA 4WURA 2UZJA 2JRIA 3ZNHA 4RNAA 3PHUA 4OVZA 1PVJA 4REZA 4OW0A 3W30A 3RNVA 3PRPA 1UKFA 4IUMA 3PHWA 4GUAA 4MM3B 5EZSA 3W31A 5EZQA 3BB7A 2DOSA 4MI7A 1DKIA 4BOZA 3TRKA 3B21A 4PT5A 5E6JA 2FE8A 2HWKA 4D8BA 2Z84A 3PSEA 3OQCA 3E9SA 4HXDB 2BTWB 3PHXA 1YZBA 4BOPA 4A5UA 4RF0A 4RKXA 4BOSA 2AGAA 3IFUA 3PT2A 4R3DA 2BU3A 3C0RA 3O65A 4D8EA 2J7QA 4RF1A 4BOQA 3PRMA 5KO3A 3MP2A 4D8IA 3BY4A 3BBAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J7Q C;  2J7Q A; 
#chains in the Genus database with same CATH topology
 3LXS A;  3V6C A;  1ME3 A;  4N4Z A;  1NLJ A;  4K7C A;  4MSX A;  5F02 A;  3IEJ A;  1BGO A;  1VSN A;  3ERV A;  1AU0 A;  1KHP A;  1PE6 A;  3HD3 A;  3I3T A;  4YYU A;  1QDQ A;  2PAD A;  1PPP A;  4BS6 A;  5FPW A;  3MTV A;  3F75 A;  1ITO A;  2BTW A;  4KLB A;  4WUR A;  4BPV A;  2DCC A;  2UZJ A;  2ATO A;  3ZNH A;  2GHU A;  2E03 A;  2YJ8 A;  4CDE B;  1VJV A;  1EWO A;  1U9V A;  3IHP A;  1PPN A;  4QRG A;  4REZ A;  4I05 A;  5PAD A;  5CHV A;  1AYU A;  1F29 A;  2NQG A;  3RNV A;  3P5V A;  3OF9 A;  3PRP A;  1GCB A;  3PHW A;  1NB5 A;  3NHE A;  4YYS A;  1AYV A;  3LFY A;  1YAL A;  4MM3 B;  3KX1 A;  1U9X A;  2AVW A;  5EZS A;  1NQC A;  5K16 A;  2NQI A;  1QXP A;  3BCN A;  2F7D A;  3IMA A;  5CVN B;  2ARY A;  2P7U A;  3M99 A;  2BDL A;  3O0U A;  3PSE A;  1PPO A;  3E9S A;  3P5X A;  5A24 A;  4I04 A;  1YZB A;  2XU4 A;  4CDC B;  3P5W A;  3N3G A;  1X9Y A;  1MIR A;  2B1N A;  1EWL A;  2FQ9 A;  2AIM A;  3BC3 A;  1CVZ A;  1HUC B;  4BOS A;  2AGA A;  2DC9 A;  3K24 A;  4P6G A;  2YJB A;  1CTE A;  4R3D A;  4YVA A;  4PAD A;  1QMY A;  2PRE A;  4YYW A;  1KHQ A;  3CBK A;  9PAP A;  4BSQ A;  1THE A;  3V6E A;  3MP2 A;  3O1G A;  3D6S A;  1PCI A;  4M0W A;  1GEC E;  4P16 A;  4CDD B;  1ATK A;  1Q6K A;  2FYE A;  1KXR A;  4MZO A;  1CPJ A;  3QSD A;  3OIS A;  4ZUX U;  1KFX L;  2OZ2 A;  3H8B A;  2R9F A;  1JQP A;  2FT2 A;  2H7J A;  2DC7 A;  2WBF X;  4ZTB A;  2JTC A;  1F2C A;  3IOQ A;  3C9E A;  5JA7 A;  2FUD A;  1EWP A;  2IPP B;  1U5I A;  1EF7 A;  2R9C A;  1BQI A;  3CH3 X;  4OVZ A;  4AXL A;  3PDF A;  2E01 A;  2OP3 A;  1CJL A;  1SP4 B;  3N4C A;  1DEU A;  3KW9 A;  3RVW A;  3H8C A;  2R6N A;  2C0Y A;  2DC6 A;  2AYO A;  1YT7 A;  3MOR A;  4XR7 A;  4N79 A;  3W31 A;  1XKG A;  3BB7 A;  2AUZ A;  2DJF B;  4PI3 A;  4N8W A;  4BQV A;  4MI7 A;  2AUX A;  3HHA A;  3B21 A;  2FRQ A;  3H6S A;  2R9O A;  3I06 A;  2HD5 A;  2HWK A;  4D8B A;  3OVZ A;  1CQD A;  3RVV A;  3IUT A;  3OQC A;  3IV2 A;  3QJ3 A;  1KFU L;  2HHN A;  2O6X A;  4PP1 A;  3KFQ A;  3WXG A;  5EF4 A;  4I07 A;  4RF0 A;  2YJ2 A;  1AU2 A;  2JQG R;  3IFU A;  8PCH A;  1TL9 A;  2P0R A;  3O65 A;  4QRV A;  3P5U A;  2J7Q A;  1FH0 A;  4FK5 A;  5JH3 A;  1A6R A;  3H89 A;  3MHH A;  4FIP A;  1CV8 A;  5CVM A;  4W5C A;  5JZE A;  4OVZ B;  2BDZ A;  1MDW A;  4X6I A;  3KSE A;  1NPZ A;  3TNX A;  4IP3 A;  4QRX A;  2JQF R;  2DC8 A;  3OF8 A;  4BOU A;  3MTN A;  7PCK A;  4YYQ A;  2E00 A;  3BPM A;  6PAD A;  4DMX A;  3KWB X;  3PHU A;  3KKU A;  1PVJ A;  2YJ9 A;  1PPD A;  1CS8 A;  4W4U A;  1AU3 A;  2G8E A;  1UKF A;  1Y08 A;  4IUM A;  1AIM A;  2ACT A;  1U9Q X;  3WXF A;  2OUL A;  3USV A;  4BS5 A;  4X6H A;  3HHI A;  1SNK A;  5EZQ A;  2DOS A;  2PNS A;  4YYR A;  4BOZ A;  1PIP A;  3B79 A;  4PT5 A;  2VHF A;  1QOL A;  2FE8 A;  2FTD A;  1PAD A;  2Z84 A;  1PXV A;  1Y4H A;  3PBH A;  4XUI A;  4HXD B;  2VHS A;  2XU1 A;  4BOP A;  2HXZ A;  2CIO A;  3BOW A;  4A5U A;  4OEM A;  5J94 A;  3WXE A;  1MEM A;  1O0E A;  1EWM A;  2BU3 A;  4X6J A;  1F2A A;  4D8E A;  1S4V A;  1YVB A;  1GLO A;  4P6E A;  2B1M A;  4RF1 A;  5KO3 A;  1K3B B;  2FRA A;  3E1Z B;  3DF0 A;  4YYV A;  3F5V A;  3BY4 A;  2R9M A;  1DF0 A;  3H7D A;  1TU6 A;  1F2B A;  2J7Q C;  2CB5 A;  2Y5B A;  3TMP A;  2R9N A;  4OEL A;  1POP A;  2DCB A;  2NQD B;  3MJ5 A;  1MHW A;  2NQA A;  2IBI A;  1ME4 A;  4QH6 A;  2HH5 A;  4XZX A;  4CZW A;  1GMY A;  2G7Y A;  3CH2 X;  2JRI A;  4AXM A;  2PBH A;  4RNA A;  3OVX A;  4D8I A;  4MZS A;  2E02 A;  2G8J A;  1YK8 A;  1ZIV A;  1AU4 A;  1BP4 A;  4OW0 A;  1M6D A;  4WA6 A;  5EGW A;  3W30 A;  1ICF A;  3K9M A;  4Q8G A;  1CB5 A;  4PP2 E;  2AS8 A;  1TLO A;  4GUA A;  4RY2 A;  3GCB A;  2DZZ A;  2FO5 A;  3HWN A;  3BWK A;  4QBB A;  2DCA A;  1STF E;  1DKI A;  2GFO A;  4CDF B;  3TRK A;  2P86 A;  4YV8 A;  2XU5 A;  5E6J A;  3K8U A;  2DZY A;  2YJC A;  2DCD A;  1MS6 A;  3BPF A;  2F1G A;  4G54 A;  2BTW B;  3PHX A;  3S3Q A;  4Q8H A;  3PW3 A;  5CVO B;  1AEC A;  4DMY A;  3RVX A;  3AI8 A;  3MHS A;  4HWY A;  1U9W A;  3U8E A;  2G6D A;  4RKX A;  2AYN A;  2Y6E A;  1AYW A;  1YK7 A;  3PT2 A;  1NL6 A;  3KWZ A;  3C0R A;  2XU3 A;  1BY8 A;  3PNR A;  1NB3 A;  3N3K A;  2AU1 A;  1CSB B;  1ZCM A;  3CBJ A;  4BOQ A;  3PRM A;  3QT4 A;  5CHT A;  1IWD A;  1MEG A;  4W5B A;  3ZUA A;  2DJG B;  4FJC A;  1PBH A;  3S3R A;  3BBA A; 
#chains in the Genus database with same CATH homology
 4M0W A;  4P16 A;  5JZE A;  4OVZ B;  2J7Q C;  3TMP A;  4IP3 A;  3MJ5 A;  4ZTB A;  2JTC A;  3MTV A;  4XZX A;  4BOU A;  2BTW A;  4WUR A;  2UZJ A;  2JRI A;  3ZNH A;  4RNA A;  3PHU A;  4OVZ A;  1PVJ A;  4REZ A;  4OW0 A;  3W30 A;  3RNV A;  3PRP A;  1UKF A;  4IUM A;  3PHW A;  4GUA A;  4MM3 B;  5EZS A;  3W31 A;  5EZQ A;  3BB7 A;  2DOS A;  4MI7 A;  1DKI A;  4BOZ A;  3TRK A;  3B21 A;  4PT5 A;  5E6J A;  2FE8 A;  2HWK A;  4D8B A;  2Z84 A;  3PSE A;  3OQC A;  3E9S A;  4HXD B;  2BTW B;  3PHX A;  1YZB A;  4BOP A;  4A5U A;  4RF0 A;  4RKX A;  4BOS A;  2AGA A;  3IFU A;  3PT2 A;  4R3D A;  2BU3 A;  3C0R A;  3O65 A;  4D8E A;  2J7Q A;  4RF1 A;  4BOQ A;  3PRM A;  5KO3 A;  3MP2 A;  4D8I A;  3BY4 A;  3BBA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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