2J7QA

Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein m48 in complex with a ubquitin-based suicide substrate
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
232
structure length
232
Chain Sequence
MKIVRASRDQSAPVYGPRAGSQCMSNCFTFLHTCYLMGIDPVLDTTSLDAVLDSGARLDAIADEKVKRQALTDHPYRLGTEIPTVIETPAGITGHALSRPFNGTAETQDLGGYKCLGILDFLTYARGKPLPVYIIVTVGVHTRGVIVARGATYVFDPHTTDLSAEAAVYVCDDFTEAISALSFFTEMIGDFYYDAVLVYFTRCRTTLISPSELLVQIMDQYKDPDIDASVMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
pubmed doi rcsb
molecule tags Hydrolase
source organism Murine cytomegalovirus
molecule keywords MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEA
total genus 69
structure length 232
sequence length 232
ec nomenclature
pdb deposition date 2006-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.120 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2j7qA00
2J7QC 2J7QA
chains in the Genus database with same CATH superfamily
2AYNA 3LFYA 1KXRA 1ME3A 1TU6A 3RNVA 1TLOA 3BB7A 1QOLA 4DMXA 2BTWB 5EGWA 3W30A 2DC8A 2WBFX 4N79A 2PNSA 3PBHA 5CHTA 2ARYA 3OF9A 1YK7A 2G6DA 1YT7A 3I3TA 2HWKA 1NB5A 3C9EA 8PCHA 4BQVA 1MDWA 2DJGB 1Q6KA 3IMAA 3WXGA 3S3RA 5J94A 1PPDA 1HUCB 3PHXA 3TNXA 4Q8GA 3N4CA 2E03A 3P5WA 1CSBB 2HHNA 1DF0A 4DMYA 2C0YA 1A6RA 1XKGA 4BOZA 2P0RA 1CB5A 3B79A 3IFUA 3IOQA 2DZYA 2ACTA 3BPMA 5EF4A 3O65A 2NQIA 3RVXA 3BOWA 5KO3A 1BY8A 1TL9A 5F02A 4MZSA 4YVAA 1EWOA 2BU3A 3E9SA 2BTWA 2DC9A 4N4ZA 4X6HA 2E00A 1IWDA 5A24A 2DOSA 1EWPA 2Y5BA 4D8BA 2PADA 1AECA 1CVZA 4D8IA 6PADA 1PPPA 4WA6A 1PADA 1MEGA 1NLJA 5E6JA 4RKXA 4X6JA 2Z84A 1ZIVA 2E02A 1GCBA 2R9MA 3GCBA 3H7DA 1CTEA 3B21A 3V6EA 4P6GA 3V6CA 3F5VA 5CVOB 1ME4A 1NL6A 2Y6EA 1EWLA 4RY2A 4BS5A 1Y08A 1BQIA 1MS6A 1KHQA 3MTNA 3KWBX 4RF0A 1SNKA 4P16A 2IBIA 2OULA 2XU3A 3U8EA 4YYRA 2G8EA 3ZNHA 3KW9A 2DZZA 1AU4A 2PBHA 3K8UA 1ATKA 4QBBA 2B1NA 3H6SA 2G8JA 3MTVA 4YV8A 4I05A 2FRAA 5EZQA 3BPFA 3I06A 5K16A 4CDDB 1U9XA 5FPWA 3PT2A 3PSEA 4QRGA 2J7QC 2FE8A 4PI3A 2AYOA 3OQCA 1KHPA 3P5UA 1PXVA 4R3DA 2R9FA 1BGOA 1QDQA 3O1GA 3MORA 3HHIA 3PRPA 3KWZA 1SP4B 3O0UA 1X9YA 3H8BA 1GECE 1U5IA 1BP4A 5EZSA 3ERVA 4XR7A 2R9OA 2FUDA 4OEMA 3K9MA 1NPZA 2VHSA 1JQPA 3BY4A 4CDCB 2J7QA 3BBAA 4ZTBA 1STFE 3OVXA 3CBKA 1AYVA 1GMYA 4OELA 4QH6A 4YYSA 1F29A 3MJ5A 4YYWA 2VHFA 1PPNA 4N8WA 2AUZA 5JZEA 1DKIA 4FJCA 2DJFB 3D6SA 4REZA 3RVVA 4YYVA 1ZCMA 2JTCA 4XZXA 1GLOA 4OVZB 4PP1A 2F7DA 2HD5A 2GHUA 4YYQA 1PVJA 2PREA 5JA7A 1AYUA 2FYEA 3USVA 4ZUXU 1QMYA 1YALA 1AYWA 1CJLA 3PRMA 1YK8A 3KSEA 4WURA 1EF7A 3OF8A 4HXDB 1U9QX 1M6DA 4X6IA 4K7CA 2R9CA 2AGAA 4Q8HA 3PHUA 1CPJA 1O0EA 4KLBA 1VJVA 2R9NA 2OZ2A 4QRXA 3ZUAA 4IUMA 4OVZA 3P5XA 1PIPA 4MI7A 3C0RA 4BOSA 4CDFB 2IPPB 4FIPA 2YJ9A 3F75A 2DC7A 4W5BA 4PADA 1UKFA 3W31A 3M99A 3BWKA 2YJBA 2JQGR 1S4VA 4I04A 4PT5A 1VSNA 1U9WA 2CB5A 2FQ9A 2YJ2A 1KFUL 2FT2A 2DC6A 3K24A 2AU1A 2F1GA 2BDLA 2NQGA 2O6XA 1CS8A 2CIOA 4XUIA 3H89A 3QJ3A 3PHWA 4D8EA 3CH3X 2HH5A 3TRKA 3MP2A 2OP3A 2XU5A 4BSQA 3IUTA 1MEMA 1THEA 2NQDB 1PE6A 1POPA 3TMPA 2B1MA 2UZJA 3PW3A 3PDFA 2P86A 2P7UA 3PNRA 3H8CA 4G54A 2DCDA 5CVMA 2AS8A 3WXFA 4BOPA 1KFXL 3KX1A 4RNAA 4W4UA 1AIMA 3N3GA 1F2AA 3IV2A 3OVZA 3NHEA 2XU1A 3DF0A 1MHWA 3RVWA 4I07A 1ICFA 3OISA 4BOUA 1F2BA 1PCIA 1CV8A 2FTDA 3BCNA 1DEUA 3MHSA 3KKUA 3P5VA 2G7YA 2H7JA 4MSXA 5JH3A 3S3QA 4A5UA 4BPVA 3LXSA 4GUAA 2AIMA 3QSDA 9PAPA 2DCAA 2DCCA 2FRQA 1PPOA 2GFOA 3HHAA 1PBHA 3KFQA 1NQCA 1U9VA 2E01A 4HWYA 2R6NA 5PADA 4YYUA 2BDZA 1AU0A 1YZBA 4W5CA 5CHVA 4BS6A 3CBJA 1Y4HA 3WXEA 2JRIA 4FK5A 3IHPA 1CQDA 2AUXA 1K3BB 2ATOA 3BC3A 4M0WA 3HWNA 4MM3B 1AU2A 2DCBA 4AXLA 1F2CA 3IEJA 1MIRA 2YJCA 4P6EA 1NB3A 1YVBA 7PCKA 4RF1A 3CH2X 4IP3A 3E1ZB 3QT4A 2XU4A 1EWMA 4BOQA 4AXMA 1QXPA 4PP2E 3AI8A 3MHHA 2AVWA 2HXZA 4CDEB 1ITOA 2NQAA 2JQFR 4CZWA 4OW0A 3HD3A 2YJ8A 4QRVA 1AU3A 2FO5A 1FH0A 4MZOA 5CVNB 3N3KA
chains in the Genus database with same CATH topology
4RF0A 4P16A 3PRMA 3RNVA 4WURA 4BOUA 3BB7A 2BTWB 3W30A 4HXDB 3ZNHA 2AGAA 3PHUA 4A5UA 2HWKA 3MTVA 4GUAA 5EZQA 3PHXA 4IUMA 3PT2A 3PSEA 2J7QC 2FE8A 4OVZA 3OQCA 4MI7A 3C0RA 4BOSA 4R3DA 3PRPA 4BOZA 1UKFA 3W31A 1YZBA 3IFUA 5EZSA 3O65A 5KO3A 4PT5A 2JRIA 3BY4A 2BU3A 2J7QA 3E9SA 3BBAA 2BTWA 4ZTBA 4M0WA 2DOSA 4MM3B 4D8BA 4D8IA 3PHWA 4D8EA 3MJ5A 5E6JA 4RKXA 4RF1A 3TRKA 3MP2A 4IP3A 2Z84A 5JZEA 1DKIA 4BOQA 3TMPA 4REZA 3B21A 2UZJA 2JTCA 4XZXA 4OVZB 4OW0A 1PVJA 4BOPA 4RNAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J7Q C;  2J7Q A; 
#chains in the Genus database with same CATH topology
 2AYN A;  3LFY A;  1KXR A;  1ME3 A;  1TU6 A;  3RNV A;  1TLO A;  3BB7 A;  1QOL A;  4DMX A;  2BTW B;  5EGW A;  3W30 A;  2DC8 A;  2WBF X;  4N79 A;  2PNS A;  3PBH A;  5CHT A;  2ARY A;  3OF9 A;  1YK7 A;  2G6D A;  1YT7 A;  3I3T A;  2HWK A;  1NB5 A;  3C9E A;  8PCH A;  4BQV A;  1MDW A;  2DJG B;  1Q6K A;  3IMA A;  3WXG A;  3S3R A;  5J94 A;  1PPD A;  1HUC B;  3PHX A;  3TNX A;  4Q8G A;  3N4C A;  2E03 A;  3P5W A;  1CSB B;  2HHN A;  1DF0 A;  4DMY A;  2C0Y A;  1A6R A;  1XKG A;  4BOZ A;  2P0R A;  1CB5 A;  3B79 A;  3IFU A;  3IOQ A;  2DZY A;  2ACT A;  3BPM A;  5EF4 A;  3O65 A;  2NQI A;  3RVX A;  3BOW A;  5KO3 A;  1BY8 A;  1TL9 A;  5F02 A;  4MZS A;  4YVA A;  1EWO A;  2BU3 A;  3E9S A;  2BTW A;  2DC9 A;  4N4Z A;  4X6H A;  2E00 A;  1IWD A;  5A24 A;  2DOS A;  1EWP A;  2Y5B A;  4D8B A;  2PAD A;  1AEC A;  1CVZ A;  4D8I A;  6PAD A;  1PPP A;  4WA6 A;  1PAD A;  1MEG A;  1NLJ A;  5E6J A;  4RKX A;  4X6J A;  2Z84 A;  1ZIV A;  2E02 A;  1GCB A;  2R9M A;  3GCB A;  3H7D A;  1CTE A;  3B21 A;  3V6E A;  4P6G A;  3V6C A;  3F5V A;  5CVO B;  1ME4 A;  1NL6 A;  2Y6E A;  1EWL A;  4RY2 A;  4BS5 A;  1Y08 A;  1BQI A;  1MS6 A;  1KHQ A;  3MTN A;  3KWB X;  4RF0 A;  1SNK A;  4P16 A;  2IBI A;  2OUL A;  2XU3 A;  3U8E A;  4YYR A;  2G8E A;  3ZNH A;  3KW9 A;  2DZZ A;  1AU4 A;  2PBH A;  3K8U A;  1ATK A;  4QBB A;  2B1N A;  3H6S A;  2G8J A;  3MTV A;  4YV8 A;  4I05 A;  2FRA A;  5EZQ A;  3BPF A;  3I06 A;  5K16 A;  4CDD B;  1U9X A;  5FPW A;  3PT2 A;  3PSE A;  4QRG A;  2J7Q C;  2FE8 A;  4PI3 A;  2AYO A;  3OQC A;  1KHP A;  3P5U A;  1PXV A;  4R3D A;  2R9F A;  1BGO A;  1QDQ A;  3O1G A;  3MOR A;  3HHI A;  3PRP A;  3KWZ A;  1SP4 B;  3O0U A;  1X9Y A;  3H8B A;  1GEC E;  1U5I A;  1BP4 A;  5EZS A;  3ERV A;  4XR7 A;  2R9O A;  2FUD A;  4OEM A;  3K9M A;  1NPZ A;  2VHS A;  1JQP A;  3BY4 A;  4CDC B;  2J7Q A;  3BBA A;  4ZTB A;  1STF E;  3OVX A;  3CBK A;  1AYV A;  1GMY A;  4OEL A;  4QH6 A;  4YYS A;  1F29 A;  3MJ5 A;  4YYW A;  2VHF A;  1PPN A;  4N8W A;  2AUZ A;  5JZE A;  1DKI A;  4FJC A;  2DJF B;  3D6S A;  4REZ A;  3RVV A;  4YYV A;  1ZCM A;  2JTC A;  4XZX A;  1GLO A;  4OVZ B;  4PP1 A;  2F7D A;  2HD5 A;  2GHU A;  4YYQ A;  1PVJ A;  2PRE A;  5JA7 A;  1AYU A;  2FYE A;  3USV A;  4ZUX U;  1QMY A;  1YAL A;  1AYW A;  1CJL A;  3PRM A;  1YK8 A;  3KSE A;  4WUR A;  1EF7 A;  3OF8 A;  4HXD B;  1U9Q X;  1M6D A;  4X6I A;  4K7C A;  2R9C A;  2AGA A;  4Q8H A;  3PHU A;  1CPJ A;  1O0E A;  4KLB A;  1VJV A;  2R9N A;  2OZ2 A;  4QRX A;  3ZUA A;  4IUM A;  4OVZ A;  3P5X A;  1PIP A;  4MI7 A;  3C0R A;  4BOS A;  4CDF B;  2IPP B;  4FIP A;  2YJ9 A;  3F75 A;  2DC7 A;  4W5B A;  4PAD A;  1UKF A;  3W31 A;  3M99 A;  3BWK A;  2YJB A;  2JQG R;  1S4V A;  4I04 A;  4PT5 A;  1VSN A;  1U9W A;  2CB5 A;  2FQ9 A;  2YJ2 A;  1KFU L;  2FT2 A;  2DC6 A;  3K24 A;  2AU1 A;  2F1G A;  2BDL A;  2NQG A;  2O6X A;  1CS8 A;  2CIO A;  4XUI A;  3H89 A;  3QJ3 A;  3PHW A;  4D8E A;  3CH3 X;  2HH5 A;  3TRK A;  3MP2 A;  2OP3 A;  2XU5 A;  4BSQ A;  3IUT A;  1MEM A;  1THE A;  2NQD B;  1PE6 A;  1POP A;  3TMP A;  2B1M A;  2UZJ A;  3PW3 A;  3PDF A;  2P86 A;  2P7U A;  3PNR A;  3H8C A;  4G54 A;  2DCD A;  5CVM A;  2AS8 A;  3WXF A;  4BOP A;  1KFX L;  3KX1 A;  4RNA A;  4W4U A;  1AIM A;  3N3G A;  1F2A A;  3IV2 A;  3OVZ A;  3NHE A;  2XU1 A;  3DF0 A;  1MHW A;  3RVW A;  4I07 A;  1ICF A;  3OIS A;  4BOU A;  1F2B A;  1PCI A;  1CV8 A;  2FTD A;  3BCN A;  1DEU A;  3MHS A;  3KKU A;  3P5V A;  2G7Y A;  2H7J A;  4MSX A;  5JH3 A;  3S3Q A;  4A5U A;  4BPV A;  3LXS A;  4GUA A;  2AIM A;  3QSD A;  9PAP A;  2DCA A;  2DCC A;  2FRQ A;  1PPO A;  2GFO A;  3HHA A;  1PBH A;  3KFQ A;  1NQC A;  1U9V A;  2E01 A;  4HWY A;  2R6N A;  5PAD A;  4YYU A;  2BDZ A;  1AU0 A;  1YZB A;  4W5C A;  5CHV A;  4BS6 A;  3CBJ A;  1Y4H A;  3WXE A;  2JRI A;  4FK5 A;  3IHP A;  1CQD A;  2AUX A;  1K3B B;  2ATO A;  3BC3 A;  4M0W A;  3HWN A;  4MM3 B;  1AU2 A;  2DCB A;  4AXL A;  1F2C A;  3IEJ A;  1MIR A;  2YJC A;  4P6E A;  1NB3 A;  1YVB A;  7PCK A;  4RF1 A;  3CH2 X;  4IP3 A;  3E1Z B;  3QT4 A;  2XU4 A;  1EWM A;  4BOQ A;  4AXM A;  1QXP A;  4PP2 E;  3AI8 A;  3MHH A;  2AVW A;  2HXZ A;  4CDE B;  1ITO A;  2NQA A;  2JQF R;  4CZW A;  4OW0 A;  3HD3 A;  2YJ8 A;  4QRV A;  1AU3 A;  2FO5 A;  1FH0 A;  4MZO A;  5CVN B;  3N3K A; 
#chains in the Genus database with same CATH homology
 4RF0 A;  4P16 A;  3PRM A;  3RNV A;  4WUR A;  4BOU A;  3BB7 A;  2BTW B;  3W30 A;  4HXD B;  3ZNH A;  2AGA A;  3PHU A;  4A5U A;  2HWK A;  3MTV A;  4GUA A;  5EZQ A;  3PHX A;  4IUM A;  3PT2 A;  3PSE A;  2J7Q C;  2FE8 A;  4OVZ A;  3OQC A;  4MI7 A;  3C0R A;  4BOS A;  4R3D A;  3PRP A;  4BOZ A;  1UKF A;  3W31 A;  1YZB A;  3IFU A;  5EZS A;  3O65 A;  5KO3 A;  4PT5 A;  2JRI A;  3BY4 A;  2BU3 A;  2J7Q A;  3E9S A;  3BBA A;  2BTW A;  4ZTB A;  4M0W A;  2DOS A;  4MM3 B;  4D8B A;  4D8I A;  3PHW A;  4D8E A;  3MJ5 A;  5E6J A;  4RKX A;  4RF1 A;  3TRK A;  3MP2 A;  4IP3 A;  2Z84 A;  5JZE A;  1DKI A;  4BOQ A;  3TMP A;  4REZ A;  3B21 A;  2UZJ A;  2JTC A;  4XZX A;  4OVZ B;  4OW0 A;  1PVJ A;  4BOP A;  4RNA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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