1AU2A

Crystal structure of the cysteine protease human cathepsin k in complex with a covalent propanone inhibitor
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
215
structure length
215
Chain Sequence
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Design of Potent and Selective Cathepsin K Inhibitors
pubmed rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords CATHEPSIN K
total genus 55
structure length 215
sequence length 215
ec nomenclature ec 3.4.22.38: Cathepsin K.
pdb deposition date 1997-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1au2A00
3V6CA 1YT7A 1PBHA 1AIMA 1EWOA 3CH3X 3E1ZB 2CB5A 3CBJA 3K24A 2OZ2A 2B1NA 2E02A 3LFYA 3MHSA 1A6RA 1KHPA 1TU6A 4I05A 5CVMA 3IUTA 4QRXA 2FQ9A 1YALA 2R9OA 2PBHA 4X6JA 1PXVA 2YJ8A 3GCBA 4CZWA 4P6GA 4YYVA 1PPPA 4KLBA 3OVXA 4X6HA 2DC8A 3MTNA 3IMAA 2G8JA 4PP1A 3BPMA 4XUIA 1VJVA 3LXSA 3RVVA 3V6EA 2R9MA 4Q8GA 1AYUA 4XR7A 1U9VA 1MS6A 1X9YA 1IWDA 2DZZA 1AU4A 3D6SA 2CIOA 1PCIA 2DZYA 4W5BA 2HXZA 4X6IA 2AUXA 2DC7A 1S4VA 2JQGR 3HWNA 4PP2E 4CDFB 1PPOA 1PPDA 4OEMA 3WXGA 4Q8HA 4CDDB 3F5VA 1YK7A 1CB5A 4MZOA 1AU3A 4YVAA 2XU1A 1PPNA 3PNRA 2DCBA 1CQDA 3KSEA 3K8UA 1CV8A 2ACTA 1JQPA 3M99A 3P5XA 1MIRA 5J94A 2Y5BA 1DF0A 2YJBA 2O6XA 5A24A 1NLJA 3K9MA 4G54A 1SP4B 1ME4A 2C0YA 3DF0A 3B79A 1F29A 3ZUAA 1CVZA 1CJLA 2R9NA 4YYWA 1BP4A 3AI8A 5EGWA 3PW3A 1K3BB 4N79A 4BQVA 3OISA 1DEUA 3CBKA 1F2CA 2AVWA 4YYSA 3H8CA 3BOWA 1POPA 3P5UA 2F7DA 1YK8A 1PIPA 2JQFR 2AYNA 4FIPA 3O0UA 2IPPB 1XKGA 3BWKA 2YJCA 4BS5A 3U8EA 4HWYA 3H8BA 2F1GA 2G6DA 1Y4HA 2B1MA 3MORA 3KX1A 3IV2A 3PDFA 2DJGB 2AIMA 2XU3A 2ARYA 2YJ9A 2R9FA 3P5VA 3I06A 3MHHA 4AXMA 2FRQA 3HHAA 2G7YA 1QOLA 1BQIA 4QRGA 3NHEA 3WXFA 5F02A 4FK5A 1PE6A 2DC6A 4W5CA 4DMYA 4N8WA 3TNXA 3OVZA 1MEGA 4YV8A 2DCDA 3KW9A 2OULA 2PREA 1CTEA 4CDCB 1EWMA 4YYRA 2FRAA 3H89A 2R9CA 4ZUXU 2DC9A 2VHSA 3WXEA 2NQGA 4YYUA 4OELA 1YVBA 4QH6A 1NB5A 2E01A 3KWZA 8PCHA 1EWPA 3N3KA 1AU0A 5CHVA 1THEA 4PADA 9PAPA 3PBHA 2XU5A 4N4ZA 3IEJA 2Y6EA 1KHQA 1KFXL 4MZSA 2FYEA 1TL9A 1GECE 1U9WA 5CVOB 3QT4A 1AYWA 2FO5A 1ME3A 1EWLA 4I07A 1NPZA 2G8EA 1U9XA 2DJFB 1BGOA 2AU1A 1MHWA 2HD5A 2HHNA 2NQDB 2E00A 2WBFX 1GMYA 4I04A 1SNKA 1ZIVA 1ATKA 3O1GA 3RVWA 4PI3A 1FH0A 4MSXA 3N4CA 5PADA 2GFOA 1F2BA 2FTDA 1STFE 4FJCA 4YYQA 2DCCA 2H7JA 2BDLA 5CVNB 5JH3A 5JA7A 1VSNA 1Y08A 1MEMA 2PADA 3IOQA 1CS8A 1M6DA 1ZCMA 1AECA 1QXPA 1QMYA 4BPVA 3USVA 3HHIA 4W4UA 3IHPA 2AYOA 1Q6KA 4DMXA 3QJ3A 1KXRA 1BY8A 2NQAA 3H7DA 1PADA 6PADA 2P0RA 1F2AA 3S3QA 3ERVA 3CH2X 1CSBB 3F75A 1QDQA 4K7CA 3P5WA 4CDEB 1NB3A 3QSDA 5K16A 3C9EA 1U9QX 2OP3A 2E03A 2BDZA 4QRVA 2VHFA 2NQIA 2GHUA 1HUCB 2DCAA 4BS6A 2XU4A 2R6NA 3KFQA 1O0EA 3OF9A 1CPJA 1GCBA 2ATOA 3N3GA 1U5IA 2IBIA 2P86A 3S3RA 1EF7A 1NQCA 4RY2A 5EF4A 3RVXA 3KWBX 3I3TA 1NL6A 2AS8A 1ITOA 1KFUL 4AXLA 1MDWA 2P7UA 4WA6A 1AYVA 1TLOA 3BC3A 7PCKA 4BSQA 3H6SA 3HD3A 2HH5A 3BPFA 4P6EA 3BCNA 4QBBA 1AU2A 3OF8A 5CHTA 2FUDA 3KKUA 2FT2A 1GLOA 2AUZA 5FPWA 2PNSA 1ICFA 2YJ2A
chains in the Genus database with same CATH superfamily
3V6CA 1YT7A 1PBHA 1AIMA 3PHWA 1EWOA 3CH3X 3E1ZB 4D8EA 2CB5A 3CBJA 2UZJA 3K24A 2OZ2A 2B1NA 2E02A 3LFYA 1DKIA 3MHSA 3MTVA 1A6RA 1KHPA 1TU6A 4XZXA 3IFUA 4I05A 5CVMA 3IUTA 4QRXA 2FQ9A 1YALA 2R9OA 2PBHA 4OVZB 4X6JA 1PXVA 3PSEA 2YJ8A 3GCBA 4CZWA 4P6GA 3W30A 4YYVA 4GUAA 1PPPA 4KLBA 2BU3A 3OVXA 4X6HA 2DC8A 3MTNA 3IMAA 2G8JA 3PHXA 4PP1A 3BPMA 3RNVA 2BTWB 4XUIA 1VJVA 3LXSA 3RVVA 3V6EA 2HWKA 2R9MA 4Q8GA 1AYUA 4XR7A 1U9VA 1MS6A 1X9YA 1IWDA 2DZZA 2Z84A 1AU4A 3D6SA 2CIOA 1PCIA 2DZYA 4W5BA 2HXZA 4X6IA 2AUXA 2DC7A 1S4VA 2JQGR 2JTCA 3HWNA 4PP2E 4CDFB 1PPOA 1PPDA 4OEMA 4IUMA 2J7QA 3WXGA 4Q8HA 4CDDB 3F5VA 1YK7A 1CB5A 4MZOA 5EZSA 1AU3A 4YVAA 2XU1A 1PPNA 2FE8A 3PNRA 2DCBA 1CQDA 3KSEA 3K8UA 1CV8A 4M0WA 2ACTA 1JQPA 3M99A 3P5XA 1MIRA 5J94A 2Y5BA 1DF0A 2YJBA 4PT5A 2O6XA 5A24A 1NLJA 3K9MA 4G54A 4D8IA 1SP4B 1ME4A 1PVJA 2C0YA 5JZEA 3DF0A 3B79A 1F29A 3ZUAA 1CVZA 3BBAA 1CJLA 2R9NA 4YYWA 1BP4A 3AI8A 5EGWA 3PW3A 1K3BB 4N79A 4BQVA 3OISA 1DEUA 1YZBA 3CBKA 1F2CA 2AVWA 4BOPA 4YYSA 3H8CA 3BOWA 1POPA 3P5UA 4ZTBA 2F7DA 1YK8A 1PIPA 2JQFR 2AYNA 4P16A 4FIPA 3O0UA 2IPPB 1XKGA 3BWKA 2YJCA 4BS5A 3BY4A 3U8EA 4IP3A 4MI7A 4HWYA 3H8BA 2F1GA 4WURA 2G6DA 1Y4HA 2B1MA 3MORA 3E9SA 3KX1A 1UKFA 3IV2A 3PDFA 2DJGB 2AIMA 2XU3A 2ARYA 2YJ9A 2R9FA 3P5VA 3MHHA 3I06A 4AXMA 4REZA 3TMPA 2FRQA 3HHAA 2G7YA 1QOLA 1BQIA 4QRGA 3NHEA 2AGAA 3WXFA 5F02A 4FK5A 3OQCA 1PE6A 2DC6A 4W5CA 4DMYA 4N8WA 3TNXA 3OVZA 1MEGA 3W31A 4YV8A 2DCDA 3KW9A 2OULA 2PREA 4R3DA 1CTEA 4CDCB 1EWMA 4YYRA 4D8BA 2FRAA 3H89A 2R9CA 4ZUXU 2DC9A 2VHSA 3WXEA 2NQGA 5E6JA 4RF0A 4YYUA 4OELA 1YVBA 4QH6A 1NB5A 2E01A 3KWZA 8PCHA 1EWPA 3N3KA 1AU0A 5CHVA 1THEA 4PADA 9PAPA 3PBHA 2XU5A 4N4ZA 3IEJA 2Y6EA 1KHQA 1KFXL 4MZSA 2FYEA 1TL9A 1GECE 1U9WA 5CVOB 3QT4A 1AYWA 2FO5A 1ME3A 1EWLA 4I07A 1NPZA 2G8EA 3B21A 3BB7A 1U9XA 2DJFB 1BGOA 2AU1A 4BOSA 1MHWA 2HD5A 2HHNA 2NQDB 2E00A 2WBFX 1GMYA 4I04A 1SNKA 1ZIVA 3PT2A 1ATKA 3O1GA 3RVWA 4PI3A 1FH0A 4MSXA 3MP2A 3N4CA 4BOUA 5PADA 2GFOA 1F2BA 2FTDA 1STFE 4FJCA 4YYQA 2DCCA 4OVZA 2H7JA 2BDLA 5CVNB 5JH3A 5JA7A 3MJ5A 1VSNA 4MM3B 1Y08A 1MEMA 2PADA 3IOQA 1CS8A 4BOQA 1M6DA 1ZCMA 1AECA 4OW0A 2BTWA 1QXPA 4A5UA 1QMYA 4BPVA 3USVA 3HHIA 4W4UA 3C0RA 3IHPA 2AYOA 1Q6KA 4RKXA 4DMXA 3QJ3A 1KXRA 1BY8A 3PHUA 2NQAA 3H7DA 1PADA 6PADA 4HXDB 2P0RA 1F2AA 3S3QA 2DOSA 3ERVA 3CH2X 1CSBB 3F75A 1QDQA 4K7CA 3P5WA 3O65A 3PRPA 4CDEB 1NB3A 3QSDA 5K16A 3C9EA 1U9QX 2OP3A 2E03A 2BDZA 4RNAA 4QRVA 2VHFA 2NQIA 2GHUA 1HUCB 2DCAA 4BS6A 4BOZA 5KO3A 2XU4A 2R6NA 3KFQA 1O0EA 3OF9A 1CPJA 1GCBA 2ATOA 3N3GA 1U5IA 2IBIA 2P86A 3S3RA 1EF7A 1NQCA 4RY2A 5EF4A 3PRMA 3RVXA 3KWBX 2JRIA 5EZQA 3I3TA 1NL6A 2AS8A 1ITOA 3TRKA 1KFUL 4AXLA 1MDWA 2P7UA 4WA6A 1AYVA 1TLOA 3BC3A 7PCKA 2J7QC 4BSQA 3H6SA 3HD3A 2HH5A 3BPFA 4P6EA 3BCNA 4QBBA 1AU2A 3OF8A 5CHTA 2FUDA 3KKUA 2FT2A 1GLOA 4RF1A 2AUZA 5FPWA 2PNSA 1ICFA 3ZNHA 2YJ2A
chains in the Genus database with same CATH topology
3V6CA 1YT7A 1PBHA 1AIMA 1EWOA 3CH3X 3E1ZB 2CB5A 3CBJA 3K24A 2OZ2A 2B1NA 2E02A 1GX3A 3LFYA 3MHSA 1A6RA 1KHPA 1TU6A 4I05A 5CVMA 3IUTA 4QRXA 2FQ9A 1YALA 2R9OA 2PBHA 4X6JA 1PXVA 2YJ8A 3GCBA 4CZWA 4P6GA 4YYVA 1PPPA 4KLBA 3LTWA 3OVXA 4X6HA 2DC8A 3MTNA 3IMAA 2G8JA 4PP1A 3BPMA 4XUIA 1VJVA 3LXSA 3RVVA 3V6EA 2R9MA 4Q8GA 1AYUA 4XR7A 1U9VA 1MS6A 1X9YA 1IWDA 2DZZA 1AU4A 3D6SA 2CIOA 1PCIA 2DZYA 4W5BA 2HXZA 4X6IA 2AUXA 2DC7A 1S4VA 2JQGR 3HWNA 4PP2E 4CDFB 1PPOA 1PPDA 4OEMA 3WXGA 4Q8HA 4CDDB 3F5VA 1W5RA 1YK7A 1CB5A 4MZOA 4GUZA 1AU3A 4YVAA 2XU1A 1PPNA 3PNRA 2DCBA 1CQDA 3KSEA 3K8UA 1CV8A 2ACTA 1JQPA 3M99A 3P5XA 1MIRA 5J94A 2Y5BA 1DF0A 2YJBA 2O6XA 5A24A 1NLJA 3K9MA 4G54A 1SP4B 1ME4A 2C0YA 3DF0A 3B79A 1F29A 3ZUAA 1CVZA 1CJLA 2R9NA 4YYWA 4NV7A 1BP4A 3AI8A 5EGWA 3PW3A 1K3BB 4N79A 4BQVA 2VFCA 3OISA 1DEUA 3CBKA 1F2CA 2AVWA 4YYSA 3H8CA 3BOWA 1POPA 3P5UA 2F7DA 1YK8A 1PIPA 2JQFR 2AYNA 4FIPA 3O0UA 2IPPB 1XKGA 3BWKA 2YJCA 4BS5A 3U8EA 4HWYA 3H8BA 2F1GA 2G6DA 1Y4HA 2B1MA 3MORA 3KX1A 3IV2A 3PDFA 2DJGB 2AIMA 2XU3A 2ARYA 2YJ9A 2R9FA 3P5VA 3I06A 3MHHA 4AXMA 2FRQA 3HHAA 2BSZA 2G7YA 1QOLA 1BQIA 4QRGA 3NHEA 3WXFA 5F02A 4FK5A 1PE6A 2DC6A 4W5CA 4DMYA 4N8WA 3TNXA 3OVZA 1MEGA 4YV8A 2DCDA 3KW9A 2OULA 2PREA 1W6FA 1CTEA 4CDCB 1EWMA 4YYRA 1W4TA 2FRAA 3H89A 2R9CA 4ZUXU 2DC9A 2VHSA 3WXEA 2NQGA 4YYUA 4OELA 1YVBA 4QH6A 1NB5A 2E01A 3KWZA 8PCHA 1EWPA 3N3KA 1AU0A 5CHVA 1THEA 4PADA 9PAPA 4B55A 3PBHA 2XU5A 4N4ZA 3IEJA 2Y6EA 1KHQA 1KFXL 4MZSA 2FYEA 1TL9A 1GECE 1U9WA 5CVOB 3QT4A 1AYWA 1E2TA 2FO5A 1ME3A 1EWLA 4I07A 1NPZA 2G8EA 1U9XA 2DJFB 1BGOA 2AU1A 1MHWA 2HD5A 2HHNA 2NQDB 2E00A 2WBFX 1GMYA 4I04A 1SNKA 1ZIVA 1ATKA 3O1GA 3RVWA 4PI3A 1FH0A 4MSXA 3N4CA 5PADA 2GFOA 1F2BA 2FTDA 1STFE 4FJCA 4YYQA 2DCCA 2H7JA 2BDLA 5CVNB 5JH3A 5JA7A 1VSNA 1Y08A 1MEMA 2PADA 3IOQA 1CS8A 1M6DA 1ZCMA 1AECA 1QXPA 1QMYA 4BPVA 3USVA 3HHIA 4W4UA 3IHPA 2AYOA 1Q6KA 4DMXA 3QJ3A 1KXRA 1BY8A 2NQAA 3H7DA 1PADA 6PADA 2P0RA 1F2AA 3S3QA 3ERVA 3CH2X 1CSBB 3F75A 4BGFA 1QDQA 4K7CA 3P5WA 4CDEB 1NB3A 3QSDA 5K16A 3C9EA 1U9QX 2OP3A 2E03A 2BDZA 4QRVA 2VHFA 2NQIA 2GHUA 1HUCB 2DCAA 4BS6A 2XU4A 2R6NA 3KFQA 1O0EA 3D9WA 3OF9A 1CPJA 4NV8A 1GCBA 2ATOA 3N3GA 1U5IA 2IBIA 2P86A 3S3RA 1EF7A 1NQCA 4C5PA 4RY2A 5EF4A 3RVXA 3KWBX 3I3TA 1NL6A 2AS8A 1ITOA 1KFUL 4AXLA 1MDWA 2P7UA 4WA6A 1AYVA 1TLOA 3BC3A 7PCKA 4BSQA 3H6SA 3HD3A 2HH5A 3BPFA 4P6EA 2VFBA 3BCNA 4QBBA 1AU2A 3OF8A 5CHTA 2FUDA 3KKUA 2FT2A 1GLOA 2AUZA 5FPWA 2PNSA 1ICFA 2YJ2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V6C A;  1YT7 A;  1PBH A;  1AIM A;  1EWO A;  3CH3 X;  3E1Z B;  2CB5 A;  3CBJ A;  3K24 A;  2OZ2 A;  2B1N A;  2E02 A;  3LFY A;  3MHS A;  1A6R A;  1KHP A;  1TU6 A;  4I05 A;  5CVM A;  3IUT A;  4QRX A;  2FQ9 A;  1YAL A;  2R9O A;  2PBH A;  4X6J A;  1PXV A;  2YJ8 A;  3GCB A;  4CZW A;  4P6G A;  4YYV A;  1PPP A;  4KLB A;  3OVX A;  4X6H A;  2DC8 A;  3MTN A;  3IMA A;  2G8J A;  4PP1 A;  3BPM A;  4XUI A;  1VJV A;  3LXS A;  3RVV A;  3V6E A;  2R9M A;  4Q8G A;  1AYU A;  4XR7 A;  1U9V A;  1MS6 A;  1X9Y A;  1IWD A;  2DZZ A;  1AU4 A;  3D6S A;  2CIO A;  1PCI A;  2DZY A;  4W5B A;  2HXZ A;  4X6I A;  2AUX A;  2DC7 A;  1S4V A;  2JQG R;  3HWN A;  4PP2 E;  4CDF B;  1PPO A;  1PPD A;  4OEM A;  3WXG A;  4Q8H A;  4CDD B;  3F5V A;  1YK7 A;  1CB5 A;  4MZO A;  1AU3 A;  4YVA A;  2XU1 A;  1PPN A;  3PNR A;  2DCB A;  1CQD A;  3KSE A;  3K8U A;  1CV8 A;  2ACT A;  1JQP A;  3M99 A;  3P5X A;  1MIR A;  5J94 A;  2Y5B A;  1DF0 A;  2YJB A;  2O6X A;  5A24 A;  1NLJ A;  3K9M A;  4G54 A;  1SP4 B;  1ME4 A;  2C0Y A;  3DF0 A;  3B79 A;  1F29 A;  3ZUA A;  1CVZ A;  1CJL A;  2R9N A;  4YYW A;  1BP4 A;  3AI8 A;  5EGW A;  3PW3 A;  1K3B B;  4N79 A;  4BQV A;  3OIS A;  1DEU A;  3CBK A;  1F2C A;  2AVW A;  4YYS A;  3H8C A;  3BOW A;  1POP A;  3P5U A;  2F7D A;  1YK8 A;  1PIP A;  2JQF R;  2AYN A;  4FIP A;  3O0U A;  2IPP B;  1XKG A;  3BWK A;  2YJC A;  4BS5 A;  3U8E A;  4HWY A;  3H8B A;  2F1G A;  2G6D A;  1Y4H A;  2B1M A;  3MOR A;  3KX1 A;  3IV2 A;  3PDF A;  2DJG B;  2AIM A;  2XU3 A;  2ARY A;  2YJ9 A;  2R9F A;  3P5V A;  3I06 A;  3MHH A;  4AXM A;  2FRQ A;  3HHA A;  2G7Y A;  1QOL A;  1BQI A;  4QRG A;  3NHE A;  3WXF A;  5F02 A;  4FK5 A;  1PE6 A;  2DC6 A;  4W5C A;  4DMY A;  4N8W A;  3TNX A;  3OVZ A;  1MEG A;  4YV8 A;  2DCD A;  3KW9 A;  2OUL A;  2PRE A;  1CTE A;  4CDC B;  1EWM A;  4YYR A;  2FRA A;  3H89 A;  2R9C A;  4ZUX U;  2DC9 A;  2VHS A;  3WXE A;  2NQG A;  4YYU A;  4OEL A;  1YVB A;  4QH6 A;  1NB5 A;  2E01 A;  3KWZ A;  8PCH A;  1EWP A;  3N3K A;  1AU0 A;  5CHV A;  1THE A;  4PAD A;  9PAP A;  3PBH A;  2XU5 A;  4N4Z A;  3IEJ A;  2Y6E A;  1KHQ A;  1KFX L;  4MZS A;  2FYE A;  1TL9 A;  1GEC E;  1U9W A;  5CVO B;  3QT4 A;  1AYW A;  2FO5 A;  1ME3 A;  1EWL A;  4I07 A;  1NPZ A;  2G8E A;  1U9X A;  2DJF B;  1BGO A;  2AU1 A;  1MHW A;  2HD5 A;  2HHN A;  2NQD B;  2E00 A;  2WBF X;  1GMY A;  4I04 A;  1SNK A;  1ZIV A;  1ATK A;  3O1G A;  3RVW A;  4PI3 A;  1FH0 A;  4MSX A;  3N4C A;  5PAD A;  2GFO A;  1F2B A;  2FTD A;  1STF E;  4FJC A;  4YYQ A;  2DCC A;  2H7J A;  2BDL A;  5CVN B;  5JH3 A;  5JA7 A;  1VSN A;  1Y08 A;  1MEM A;  2PAD A;  3IOQ A;  1CS8 A;  1M6D A;  1ZCM A;  1AEC A;  1QXP A;  1QMY A;  4BPV A;  3USV A;  3HHI A;  4W4U A;  3IHP A;  2AYO A;  1Q6K A;  4DMX A;  3QJ3 A;  1KXR A;  1BY8 A;  2NQA A;  3H7D A;  1PAD A;  6PAD A;  2P0R A;  1F2A A;  3S3Q A;  3ERV A;  3CH2 X;  1CSB B;  3F75 A;  1QDQ A;  4K7C A;  3P5W A;  4CDE B;  1NB3 A;  3QSD A;  5K16 A;  3C9E A;  1U9Q X;  2OP3 A;  2E03 A;  2BDZ A;  4QRV A;  2VHF A;  2NQI A;  2GHU A;  1HUC B;  2DCA A;  4BS6 A;  2XU4 A;  2R6N A;  3KFQ A;  1O0E A;  3OF9 A;  1CPJ A;  1GCB A;  2ATO A;  3N3G A;  1U5I A;  2IBI A;  2P86 A;  3S3R A;  1EF7 A;  1NQC A;  4RY2 A;  5EF4 A;  3RVX A;  3KWB X;  3I3T A;  1NL6 A;  2AS8 A;  1ITO A;  1KFU L;  4AXL A;  1MDW A;  2P7U A;  4WA6 A;  1AYV A;  1TLO A;  3BC3 A;  7PCK A;  4BSQ A;  3H6S A;  3HD3 A;  2HH5 A;  3BPF A;  4P6E A;  3BCN A;  4QBB A;  1AU2 A;  3OF8 A;  5CHT A;  2FUD A;  3KKU A;  2FT2 A;  1GLO A;  2AUZ A;  5FPW A;  2PNS A;  1ICF A;  2YJ2 A; 
#chains in the Genus database with same CATH topology
 3V6C A;  1YT7 A;  1PBH A;  1AIM A;  3PHW A;  1EWO A;  3CH3 X;  3E1Z B;  4D8E A;  2CB5 A;  3CBJ A;  2UZJ A;  3K24 A;  2OZ2 A;  2B1N A;  2E02 A;  3LFY A;  1DKI A;  3MHS A;  3MTV A;  1A6R A;  1KHP A;  1TU6 A;  4XZX A;  3IFU A;  4I05 A;  5CVM A;  3IUT A;  4QRX A;  2FQ9 A;  1YAL A;  2R9O A;  2PBH A;  4OVZ B;  4X6J A;  1PXV A;  3PSE A;  2YJ8 A;  3GCB A;  4CZW A;  4P6G A;  3W30 A;  4YYV A;  4GUA A;  1PPP A;  4KLB A;  2BU3 A;  3OVX A;  4X6H A;  2DC8 A;  3MTN A;  3IMA A;  2G8J A;  3PHX A;  4PP1 A;  3BPM A;  3RNV A;  2BTW B;  4XUI A;  1VJV A;  3LXS A;  3RVV A;  3V6E A;  2HWK A;  2R9M A;  4Q8G A;  1AYU A;  4XR7 A;  1U9V A;  1MS6 A;  1X9Y A;  1IWD A;  2DZZ A;  2Z84 A;  1AU4 A;  3D6S A;  2CIO A;  1PCI A;  2DZY A;  4W5B A;  2HXZ A;  4X6I A;  2AUX A;  2DC7 A;  1S4V A;  2JQG R;  2JTC A;  3HWN A;  4PP2 E;  4CDF B;  1PPO A;  1PPD A;  4OEM A;  4IUM A;  2J7Q A;  3WXG A;  4Q8H A;  4CDD B;  3F5V A;  1YK7 A;  1CB5 A;  4MZO A;  5EZS A;  1AU3 A;  4YVA A;  2XU1 A;  1PPN A;  2FE8 A;  3PNR A;  2DCB A;  1CQD A;  3KSE A;  3K8U A;  1CV8 A;  4M0W A;  2ACT A;  1JQP A;  3M99 A;  3P5X A;  1MIR A;  5J94 A;  2Y5B A;  1DF0 A;  2YJB A;  4PT5 A;  2O6X A;  5A24 A;  1NLJ A;  3K9M A;  4G54 A;  4D8I A;  1SP4 B;  1ME4 A;  1PVJ A;  2C0Y A;  5JZE A;  3DF0 A;  3B79 A;  1F29 A;  3ZUA A;  1CVZ A;  3BBA A;  1CJL A;  2R9N A;  4YYW A;  1BP4 A;  3AI8 A;  5EGW A;  3PW3 A;  1K3B B;  4N79 A;  4BQV A;  3OIS A;  1DEU A;  1YZB A;  3CBK A;  1F2C A;  2AVW A;  4BOP A;  4YYS A;  3H8C A;  3BOW A;  1POP A;  3P5U A;  4ZTB A;  2F7D A;  1YK8 A;  1PIP A;  2JQF R;  2AYN A;  4P16 A;  4FIP A;  3O0U A;  2IPP B;  1XKG A;  3BWK A;  2YJC A;  4BS5 A;  3BY4 A;  3U8E A;  4IP3 A;  4MI7 A;  4HWY A;  3H8B A;  2F1G A;  4WUR A;  2G6D A;  1Y4H A;  2B1M A;  3MOR A;  3E9S A;  3KX1 A;  1UKF A;  3IV2 A;  3PDF A;  2DJG B;  2AIM A;  2XU3 A;  2ARY A;  2YJ9 A;  2R9F A;  3P5V A;  3MHH A;  3I06 A;  4AXM A;  4REZ A;  3TMP A;  2FRQ A;  3HHA A;  2G7Y A;  1QOL A;  1BQI A;  4QRG A;  3NHE A;  2AGA A;  3WXF A;  5F02 A;  4FK5 A;  3OQC A;  1PE6 A;  2DC6 A;  4W5C A;  4DMY A;  4N8W A;  3TNX A;  3OVZ A;  1MEG A;  3W31 A;  4YV8 A;  2DCD A;  3KW9 A;  2OUL A;  2PRE A;  4R3D A;  1CTE A;  4CDC B;  1EWM A;  4YYR A;  4D8B A;  2FRA A;  3H89 A;  2R9C A;  4ZUX U;  2DC9 A;  2VHS A;  3WXE A;  2NQG A;  5E6J A;  4RF0 A;  4YYU A;  4OEL A;  1YVB A;  4QH6 A;  1NB5 A;  2E01 A;  3KWZ A;  8PCH A;  1EWP A;  3N3K A;  1AU0 A;  5CHV A;  1THE A;  4PAD A;  9PAP A;  3PBH A;  2XU5 A;  4N4Z A;  3IEJ A;  2Y6E A;  1KHQ A;  1KFX L;  4MZS A;  2FYE A;  1TL9 A;  1GEC E;  1U9W A;  5CVO B;  3QT4 A;  1AYW A;  2FO5 A;  1ME3 A;  1EWL A;  4I07 A;  1NPZ A;  2G8E A;  3B21 A;  3BB7 A;  1U9X A;  2DJF B;  1BGO A;  2AU1 A;  4BOS A;  1MHW A;  2HD5 A;  2HHN A;  2NQD B;  2E00 A;  2WBF X;  1GMY A;  4I04 A;  1SNK A;  1ZIV A;  3PT2 A;  1ATK A;  3O1G A;  3RVW A;  4PI3 A;  1FH0 A;  4MSX A;  3MP2 A;  3N4C A;  4BOU A;  5PAD A;  2GFO A;  1F2B A;  2FTD A;  1STF E;  4FJC A;  4YYQ A;  2DCC A;  4OVZ A;  2H7J A;  2BDL A;  5CVN B;  5JH3 A;  5JA7 A;  3MJ5 A;  1VSN A;  4MM3 B;  1Y08 A;  1MEM A;  2PAD A;  3IOQ A;  1CS8 A;  4BOQ A;  1M6D A;  1ZCM A;  1AEC A;  4OW0 A;  2BTW A;  1QXP A;  4A5U A;  1QMY A;  4BPV A;  3USV A;  3HHI A;  4W4U A;  3C0R A;  3IHP A;  2AYO A;  1Q6K A;  4RKX A;  4DMX A;  3QJ3 A;  1KXR A;  1BY8 A;  3PHU A;  2NQA A;  3H7D A;  1PAD A;  6PAD A;  4HXD B;  2P0R A;  1F2A A;  3S3Q A;  2DOS A;  3ERV A;  3CH2 X;  1CSB B;  3F75 A;  1QDQ A;  4K7C A;  3P5W A;  3O65 A;  3PRP A;  4CDE B;  1NB3 A;  3QSD A;  5K16 A;  3C9E A;  1U9Q X;  2OP3 A;  2E03 A;  2BDZ A;  4RNA A;  4QRV A;  2VHF A;  2NQI A;  2GHU A;  1HUC B;  2DCA A;  4BS6 A;  4BOZ A;  5KO3 A;  2XU4 A;  2R6N A;  3KFQ A;  1O0E A;  3OF9 A;  1CPJ A;  1GCB A;  2ATO A;  3N3G A;  1U5I A;  2IBI A;  2P86 A;  3S3R A;  1EF7 A;  1NQC A;  4RY2 A;  5EF4 A;  3PRM A;  3RVX A;  3KWB X;  2JRI A;  5EZQ A;  3I3T A;  1NL6 A;  2AS8 A;  1ITO A;  3TRK A;  1KFU L;  4AXL A;  1MDW A;  2P7U A;  4WA6 A;  1AYV A;  1TLO A;  3BC3 A;  7PCK A;  2J7Q C;  4BSQ A;  3H6S A;  3HD3 A;  2HH5 A;  3BPF A;  4P6E A;  3BCN A;  4QBB A;  1AU2 A;  3OF8 A;  5CHT A;  2FUD A;  3KKU A;  2FT2 A;  1GLO A;  4RF1 A;  2AUZ A;  5FPW A;  2PNS A;  1ICF A;  3ZNH A;  2YJ2 A; 
#chains in the Genus database with same CATH homology
 3V6C A;  1YT7 A;  1PBH A;  1AIM A;  1EWO A;  3CH3 X;  3E1Z B;  2CB5 A;  3CBJ A;  3K24 A;  2OZ2 A;  2B1N A;  2E02 A;  1GX3 A;  3LFY A;  3MHS A;  1A6R A;  1KHP A;  1TU6 A;  4I05 A;  5CVM A;  3IUT A;  4QRX A;  2FQ9 A;  1YAL A;  2R9O A;  2PBH A;  4X6J A;  1PXV A;  2YJ8 A;  3GCB A;  4CZW A;  4P6G A;  4YYV A;  1PPP A;  4KLB A;  3LTW A;  3OVX A;  4X6H A;  2DC8 A;  3MTN A;  3IMA A;  2G8J A;  4PP1 A;  3BPM A;  4XUI A;  1VJV A;  3LXS A;  3RVV A;  3V6E A;  2R9M A;  4Q8G A;  1AYU A;  4XR7 A;  1U9V A;  1MS6 A;  1X9Y A;  1IWD A;  2DZZ A;  1AU4 A;  3D6S A;  2CIO A;  1PCI A;  2DZY A;  4W5B A;  2HXZ A;  4X6I A;  2AUX A;  2DC7 A;  1S4V A;  2JQG R;  3HWN A;  4PP2 E;  4CDF B;  1PPO A;  1PPD A;  4OEM A;  3WXG A;  4Q8H A;  4CDD B;  3F5V A;  1W5R A;  1YK7 A;  1CB5 A;  4MZO A;  4GUZ A;  1AU3 A;  4YVA A;  2XU1 A;  1PPN A;  3PNR A;  2DCB A;  1CQD A;  3KSE A;  3K8U A;  1CV8 A;  2ACT A;  1JQP A;  3M99 A;  3P5X A;  1MIR A;  5J94 A;  2Y5B A;  1DF0 A;  2YJB A;  2O6X A;  5A24 A;  1NLJ A;  3K9M A;  4G54 A;  1SP4 B;  1ME4 A;  2C0Y A;  3DF0 A;  3B79 A;  1F29 A;  3ZUA A;  1CVZ A;  1CJL A;  2R9N A;  4YYW A;  4NV7 A;  1BP4 A;  3AI8 A;  5EGW A;  3PW3 A;  1K3B B;  4N79 A;  4BQV A;  2VFC A;  3OIS A;  1DEU A;  3CBK A;  1F2C A;  2AVW A;  4YYS A;  3H8C A;  3BOW A;  1POP A;  3P5U A;  2F7D A;  1YK8 A;  1PIP A;  2JQF R;  2AYN A;  4FIP A;  3O0U A;  2IPP B;  1XKG A;  3BWK A;  2YJC A;  4BS5 A;  3U8E A;  4HWY A;  3H8B A;  2F1G A;  2G6D A;  1Y4H A;  2B1M A;  3MOR A;  3KX1 A;  3IV2 A;  3PDF A;  2DJG B;  2AIM A;  2XU3 A;  2ARY A;  2YJ9 A;  2R9F A;  3P5V A;  3I06 A;  3MHH A;  4AXM A;  2FRQ A;  3HHA A;  2BSZ A;  2G7Y A;  1QOL A;  1BQI A;  4QRG A;  3NHE A;  3WXF A;  5F02 A;  4FK5 A;  1PE6 A;  2DC6 A;  4W5C A;  4DMY A;  4N8W A;  3TNX A;  3OVZ A;  1MEG A;  4YV8 A;  2DCD A;  3KW9 A;  2OUL A;  2PRE A;  1W6F A;  1CTE A;  4CDC B;  1EWM A;  4YYR A;  1W4T A;  2FRA A;  3H89 A;  2R9C A;  4ZUX U;  2DC9 A;  2VHS A;  3WXE A;  2NQG A;  4YYU A;  4OEL A;  1YVB A;  4QH6 A;  1NB5 A;  2E01 A;  3KWZ A;  8PCH A;  1EWP A;  3N3K A;  1AU0 A;  5CHV A;  1THE A;  4PAD A;  9PAP A;  4B55 A;  3PBH A;  2XU5 A;  4N4Z A;  3IEJ A;  2Y6E A;  1KHQ A;  1KFX L;  4MZS A;  2FYE A;  1TL9 A;  1GEC E;  1U9W A;  5CVO B;  3QT4 A;  1AYW A;  1E2T A;  2FO5 A;  1ME3 A;  1EWL A;  4I07 A;  1NPZ A;  2G8E A;  1U9X A;  2DJF B;  1BGO A;  2AU1 A;  1MHW A;  2HD5 A;  2HHN A;  2NQD B;  2E00 A;  2WBF X;  1GMY A;  4I04 A;  1SNK A;  1ZIV A;  1ATK A;  3O1G A;  3RVW A;  4PI3 A;  1FH0 A;  4MSX A;  3N4C A;  5PAD A;  2GFO A;  1F2B A;  2FTD A;  1STF E;  4FJC A;  4YYQ A;  2DCC A;  2H7J A;  2BDL A;  5CVN B;  5JH3 A;  5JA7 A;  1VSN A;  1Y08 A;  1MEM A;  2PAD A;  3IOQ A;  1CS8 A;  1M6D A;  1ZCM A;  1AEC A;  1QXP A;  1QMY A;  4BPV A;  3USV A;  3HHI A;  4W4U A;  3IHP A;  2AYO A;  1Q6K A;  4DMX A;  3QJ3 A;  1KXR A;  1BY8 A;  2NQA A;  3H7D A;  1PAD A;  6PAD A;  2P0R A;  1F2A A;  3S3Q A;  3ERV A;  3CH2 X;  1CSB B;  3F75 A;  4BGF A;  1QDQ A;  4K7C A;  3P5W A;  4CDE B;  1NB3 A;  3QSD A;  5K16 A;  3C9E A;  1U9Q X;  2OP3 A;  2E03 A;  2BDZ A;  4QRV A;  2VHF A;  2NQI A;  2GHU A;  1HUC B;  2DCA A;  4BS6 A;  2XU4 A;  2R6N A;  3KFQ A;  1O0E A;  3D9W A;  3OF9 A;  1CPJ A;  4NV8 A;  1GCB A;  2ATO A;  3N3G A;  1U5I A;  2IBI A;  2P86 A;  3S3R A;  1EF7 A;  1NQC A;  4C5P A;  4RY2 A;  5EF4 A;  3RVX A;  3KWB X;  3I3T A;  1NL6 A;  2AS8 A;  1ITO A;  1KFU L;  4AXL A;  1MDW A;  2P7U A;  4WA6 A;  1AYV A;  1TLO A;  3BC3 A;  7PCK A;  4BSQ A;  3H6S A;  3HD3 A;  2HH5 A;  3BPF A;  4P6E A;  2VFB A;  3BCN A;  4QBB A;  1AU2 A;  3OF8 A;  5CHT A;  2FUD A;  3KKU A;  2FT2 A;  1GLO A;  2AUZ A;  5FPW A;  2PNS A;  1ICF A;  2YJ2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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