4D8IA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase/hydrolase inhibitor
total genus 81
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8iA00
4D8EA 2UZJA 4D8BA 1DKIA 4D8IA 4RKXA 2JTCA 3BB7A 1PVJA 3BBAA
chains in the Genus database with same CATH superfamily
4CZWA 2G8EA 4MM3B 4OELA 5CVOB 2BU3A 2DOSA 3PT2A 3B21A 4YYRA 2AGAA 2XU1A 5A24A 3PRPA 1NL6A 2UZJA 4AXLA 2ARYA 2GHUA 2P0RA 4W5BA 1MDWA 1AYVA 2YJ2A 2O6XA 1CS8A 3D6SA 2YJ9A 3MJ5A 2FRAA 3KKUA 3U8EA 3IFUA 2XU4A 2R9CA 2PBHA 2AVWA 2G7YA 2VHFA 5KO3A 1POPA 2PREA 4OW0A 5E6JA 3MTNA 3HHAA 2R9MA 1ATKA 1EWLA 3I06A 2G8JA 3OVXA 2FT2A 2H7JA 4Q8GA 1AYWA 1GECE 5CHTA 2HHNA 3H7DA 2DCDA 2OP3A 3PHUA 4BPVA 1PCIA 4BOQA 4W5CA 3BPMA 1KFUL 2AUXA 1QXPA 4I04A 4BOUA 3PDFA 4RF0A 4P16A 1AU2A 4IP3A 2E02A 4DMYA 4PADA 2HXZA 3ERVA 1F2BA 2BTWA 4YVAA 4D8IA 3CBKA 4RY2A 4G54A 5K16A 1THEA 2DC9A 1F29A 3TMPA 1DF0A 2AIMA 2E01A 2FUDA 2R9FA 4X6IA 3IHPA 3BBAA 1PBHA 4I07A 5CVMA 5CHVA 4BS6A 3ZUAA 4BOZA 3C0RA 1CVZA 5JA7A 1ICFA 1ITOA 3RNVA 8PCHA 2DZYA 9PAPA 2AUZA 1STFE 2BDLA 3KSEA 3H89A 2R9NA 1U9WA 1CSBB 4RF1A 5EZSA 1PIPA 3QJ3A 5CVNB 3PSEA 3PHXA 4X6HA 4AXMA 3H8CA 3IEJA 2Y6EA 2YJCA 4DMXA 2VHSA 3K8UA 4D8BA 3RVXA 1EF7A 4R3DA 5J94A 1MHWA 2DJFB 3OQCA 2JQGR 2YJ8A 2F1GA 3PHWA 2BTWB 3IV2A 2ATOA 2AYOA 2GFOA 4K7CA 1U9QX 4ZTBA 3BB7A 2DC6A 7PCKA 1CQDA 3E9SA 2YJBA 2NQDB 4RNAA 1SNKA 2NQGA 1YALA 3S3RA 3QT4A 2FYEA 4YYSA 2DZZA 1UKFA 1BY8A 1TLOA 4PP2E 4BOPA 3W31A 2P86A 3W30A 5EGWA 1EWMA 1U5IA 4N8WA 1AU4A 4YV8A 1YK7A 3OF8A 1AECA 3N3KA 1MEGA 4W4UA 3BY4A 1AIMA 1X9YA 3HD3A 3USVA 3PW3A 3F75A 4RKXA 4QRXA 2AS8A 1S4VA 1YVBA 2Y5BA 3O0UA 1BP4A 4CDEB 1VJVA 2DC8A 3OVZA 2XU5A 4WURA 2Z84A 4MZOA 1BQIA 2PADA 5PADA 3RVVA 2B1NA 3TNXA 4YYVA 3BPFA 1PPOA 4OVZA 1PPPA 3BC3A 1A6RA 1DEUA 2OULA 1DKIA 1Y4HA 4BOSA 1K3BB 3I3TA 4P6EA 4FJCA 1Y08A 3S3QA 3WXEA 4MSXA 1ME3A 2HH5A 5FPWA 1NLJA 2JRIA 2NQAA 4HWYA 4PP1A 1KHQA 1QDQA 1PPNA 1YT7A 2WBFX 3E1ZB 5EZQA 3MORA 2R9OA 4FIPA 3OISA 1AU0A 3OF9A 2FRQA 1YZBA 4N4ZA 4YYQA 3IOQA 3P5VA 3K9MA 3K24A 4XUIA 2J7QC 1TL9A 2CIOA 3PNRA 4I05A 4P6GA 1PPDA 1NPZA 3KWZA 3P5XA 4GUAA 1F2CA 3QSDA 3C9EA 4BS5A 1QOLA 2AYNA 1GCBA 1TU6A 3GCBA 3RVWA 3IMAA 1NB5A 3F5VA 4OEMA 4WA6A 4M0WA 3MTVA 2XU3A 2R6NA 1AYUA 1SP4B 2HWKA 1CJLA 4D8EA 4REZA 1MIRA 1QMYA 4A5UA 4BSQA 1EWOA 2P7UA 3H6SA 5JZEA 6PADA 1FH0A 3AI8A 3WXGA 4XR7A 1MEMA 2DCAA 3KX1A 1M6DA 4OVZB 3MP2A 3MHSA 3HHIA 1PVJA 4YYWA 4MZSA 1O0EA 5EF4A 3WXFA 4Q8HA 1ZIVA 1HUCB 1KHPA 4FK5A 3V6CA 1PADA 2FQ9A 1KXRA 4HXDB 3NHEA 1XKGA 2G6DA 3ZNHA 4BQVA 3PRMA 3P5WA 3CH3X 4PT5A 2JTCA 2CB5A 4N79A 2DCCA 3IUTA 3DF0A 2DC7A 2IBIA 4QRVA 2B1MA 4MI7A 3BCNA 3N4CA 1NB3A 3LXSA 1YK8A 2F7DA 5JH3A 1ME4A 3KFQA 1CTEA 3H8BA 4QRGA 1F2AA 2FO5A 2E00A 3BWKA 4YYUA 2FTDA 2IPPB 2AU1A 4CDDB 5F02A 1ZCMA 3BOWA 3M99A 2DJGB 1CV8A 3TRKA 2JQFR 1BGOA 3CH2X 4QBBA 4KLBA 3N3GA 4IUMA 3HWNA 4PI3A 1NQCA 1MS6A 2ACTA 1CPJA 2HD5A 1Q6KA 1IWDA 1AU3A 1JQPA 1PXVA 1GLOA 4CDCB 1PE6A 3B79A 2C0YA 2NQIA 3KWBX 1VSNA 3P5UA 1EWPA 1CB5A 2DCBA 3KW9A 4QH6A 4ZUXU 4CDFB 1GMYA 4X6JA 3LFYA 3O1GA 2PNSA 3O65A 1U9XA 2J7QA 3PBHA 2BDZA 2FE8A 2E03A 1KFXL 4XZXA 3V6EA 2OZ2A 3CBJA 1U9VA 3MHHA
chains in the Genus database with same CATH topology
3PRMA 4MM3B 4BOZA 3C0RA 2BU3A 2DOSA 2JTCA 4PT5A 3PT2A 3B21A 4WURA 2Z84A 2AGAA 4MI7A 3RNVA 3PRPA 2UZJA 4OVZA 1DKIA 4RF1A 4BOSA 5EZSA 3MJ5A 3PSEA 2JRIA 3PHXA 3IFUA 5EZQA 3TRKA 4D8BA 4R3DA 5KO3A 1YZBA 4OW0A 5E6JA 3OQCA 2J7QC 4IUMA 4GUAA 3PHWA 2BTWB 4ZTBA 3BB7A 4M0WA 3MTVA 3E9SA 2HWKA 3PHUA 4RNAA 4D8EA 4BOQA 4REZA 4A5UA 1UKFA 4BOUA 4BOPA 4RF0A 3W31A 4P16A 3W30A 5JZEA 3O65A 4IP3A 2J7QA 2BTWA 4D8IA 4OVZB 3BY4A 3MP2A 2FE8A 1PVJA 4RKXA 4XZXA 3TMPA 4HXDB 3BBAA 3ZNHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8E A;  2UZJ A;  4D8B A;  1DKI A;  4D8I A;  4RKX A;  2JTC A;  3BB7 A;  1PVJ A;  3BBA A; 
#chains in the Genus database with same CATH topology
 4CZW A;  2G8E A;  4MM3 B;  4OEL A;  5CVO B;  2BU3 A;  2DOS A;  3PT2 A;  3B21 A;  4YYR A;  2AGA A;  2XU1 A;  5A24 A;  3PRP A;  1NL6 A;  2UZJ A;  4AXL A;  2ARY A;  2GHU A;  2P0R A;  4W5B A;  1MDW A;  1AYV A;  2YJ2 A;  2O6X A;  1CS8 A;  3D6S A;  2YJ9 A;  3MJ5 A;  2FRA A;  3KKU A;  3U8E A;  3IFU A;  2XU4 A;  2R9C A;  2PBH A;  2AVW A;  2G7Y A;  2VHF A;  5KO3 A;  1POP A;  2PRE A;  4OW0 A;  5E6J A;  3MTN A;  3HHA A;  2R9M A;  1ATK A;  1EWL A;  3I06 A;  2G8J A;  3OVX A;  2FT2 A;  2H7J A;  4Q8G A;  1AYW A;  1GEC E;  5CHT A;  2HHN A;  3H7D A;  2DCD A;  2OP3 A;  3PHU A;  4BPV A;  1PCI A;  4BOQ A;  4W5C A;  3BPM A;  1KFU L;  2AUX A;  1QXP A;  4I04 A;  4BOU A;  3PDF A;  4RF0 A;  4P16 A;  1AU2 A;  4IP3 A;  2E02 A;  4DMY A;  4PAD A;  2HXZ A;  3ERV A;  1F2B A;  2BTW A;  4YVA A;  4D8I A;  3CBK A;  4RY2 A;  4G54 A;  5K16 A;  1THE A;  2DC9 A;  1F29 A;  3TMP A;  1DF0 A;  2AIM A;  2E01 A;  2FUD A;  2R9F A;  4X6I A;  3IHP A;  3BBA A;  1PBH A;  4I07 A;  5CVM A;  5CHV A;  4BS6 A;  3ZUA A;  4BOZ A;  3C0R A;  1CVZ A;  5JA7 A;  1ICF A;  1ITO A;  3RNV A;  8PCH A;  2DZY A;  9PAP A;  2AUZ A;  1STF E;  2BDL A;  3KSE A;  3H89 A;  2R9N A;  1U9W A;  1CSB B;  4RF1 A;  5EZS A;  1PIP A;  3QJ3 A;  5CVN B;  3PSE A;  3PHX A;  4X6H A;  4AXM A;  3H8C A;  3IEJ A;  2Y6E A;  2YJC A;  4DMX A;  2VHS A;  3K8U A;  4D8B A;  3RVX A;  1EF7 A;  4R3D A;  5J94 A;  1MHW A;  2DJF B;  3OQC A;  2JQG R;  2YJ8 A;  2F1G A;  3PHW A;  2BTW B;  3IV2 A;  2ATO A;  2AYO A;  2GFO A;  4K7C A;  1U9Q X;  4ZTB A;  3BB7 A;  2DC6 A;  7PCK A;  1CQD A;  3E9S A;  2YJB A;  2NQD B;  4RNA A;  1SNK A;  2NQG A;  1YAL A;  3S3R A;  3QT4 A;  2FYE A;  4YYS A;  2DZZ A;  1UKF A;  1BY8 A;  1TLO A;  4PP2 E;  4BOP A;  3W31 A;  2P86 A;  3W30 A;  5EGW A;  1EWM A;  1U5I A;  4N8W A;  1AU4 A;  4YV8 A;  1YK7 A;  3OF8 A;  1AEC A;  3N3K A;  1MEG A;  4W4U A;  3BY4 A;  1AIM A;  1X9Y A;  3HD3 A;  3USV A;  3PW3 A;  3F75 A;  4RKX A;  4QRX A;  2AS8 A;  1S4V A;  1YVB A;  2Y5B A;  3O0U A;  1BP4 A;  4CDE B;  1VJV A;  2DC8 A;  3OVZ A;  2XU5 A;  4WUR A;  2Z84 A;  4MZO A;  1BQI A;  2PAD A;  5PAD A;  3RVV A;  2B1N A;  3TNX A;  4YYV A;  3BPF A;  1PPO A;  4OVZ A;  1PPP A;  3BC3 A;  1A6R A;  1DEU A;  2OUL A;  1DKI A;  1Y4H A;  4BOS A;  1K3B B;  3I3T A;  4P6E A;  4FJC A;  1Y08 A;  3S3Q A;  3WXE A;  4MSX A;  1ME3 A;  2HH5 A;  5FPW A;  1NLJ A;  2JRI A;  2NQA A;  4HWY A;  4PP1 A;  1KHQ A;  1QDQ A;  1PPN A;  1YT7 A;  2WBF X;  3E1Z B;  5EZQ A;  3MOR A;  2R9O A;  4FIP A;  3OIS A;  1AU0 A;  3OF9 A;  2FRQ A;  1YZB A;  4N4Z A;  4YYQ A;  3IOQ A;  3P5V A;  3K9M A;  3K24 A;  4XUI A;  2J7Q C;  1TL9 A;  2CIO A;  3PNR A;  4I05 A;  4P6G A;  1PPD A;  1NPZ A;  3KWZ A;  3P5X A;  4GUA A;  1F2C A;  3QSD A;  3C9E A;  4BS5 A;  1QOL A;  2AYN A;  1GCB A;  1TU6 A;  3GCB A;  3RVW A;  3IMA A;  1NB5 A;  3F5V A;  4OEM A;  4WA6 A;  4M0W A;  3MTV A;  2XU3 A;  2R6N A;  1AYU A;  1SP4 B;  2HWK A;  1CJL A;  4D8E A;  4REZ A;  1MIR A;  1QMY A;  4A5U A;  4BSQ A;  1EWO A;  2P7U A;  3H6S A;  5JZE A;  6PAD A;  1FH0 A;  3AI8 A;  3WXG A;  4XR7 A;  1MEM A;  2DCA A;  3KX1 A;  1M6D A;  4OVZ B;  3MP2 A;  3MHS A;  3HHI A;  1PVJ A;  4YYW A;  4MZS A;  1O0E A;  5EF4 A;  3WXF A;  4Q8H A;  1ZIV A;  1HUC B;  1KHP A;  4FK5 A;  3V6C A;  1PAD A;  2FQ9 A;  1KXR A;  4HXD B;  3NHE A;  1XKG A;  2G6D A;  3ZNH A;  4BQV A;  3PRM A;  3P5W A;  3CH3 X;  4PT5 A;  2JTC A;  2CB5 A;  4N79 A;  2DCC A;  3IUT A;  3DF0 A;  2DC7 A;  2IBI A;  4QRV A;  2B1M A;  4MI7 A;  3BCN A;  3N4C A;  1NB3 A;  3LXS A;  1YK8 A;  2F7D A;  5JH3 A;  1ME4 A;  3KFQ A;  1CTE A;  3H8B A;  4QRG A;  1F2A A;  2FO5 A;  2E00 A;  3BWK A;  4YYU A;  2FTD A;  2IPP B;  2AU1 A;  4CDD B;  5F02 A;  1ZCM A;  3BOW A;  3M99 A;  2DJG B;  1CV8 A;  3TRK A;  2JQF R;  1BGO A;  3CH2 X;  4QBB A;  4KLB A;  3N3G A;  4IUM A;  3HWN A;  4PI3 A;  1NQC A;  1MS6 A;  2ACT A;  1CPJ A;  2HD5 A;  1Q6K A;  1IWD A;  1AU3 A;  1JQP A;  1PXV A;  1GLO A;  4CDC B;  1PE6 A;  3B79 A;  2C0Y A;  2NQI A;  3KWB X;  1VSN A;  3P5U A;  1EWP A;  1CB5 A;  2DCB A;  3KW9 A;  4QH6 A;  4ZUX U;  4CDF B;  1GMY A;  4X6J A;  3LFY A;  3O1G A;  2PNS A;  3O65 A;  1U9X A;  2J7Q A;  3PBH A;  2BDZ A;  2FE8 A;  2E03 A;  1KFX L;  4XZX A;  3V6E A;  2OZ2 A;  3CBJ A;  1U9V A;  3MHH A; 
#chains in the Genus database with same CATH homology
 3PRM A;  4MM3 B;  4BOZ A;  3C0R A;  2BU3 A;  2DOS A;  2JTC A;  4PT5 A;  3PT2 A;  3B21 A;  4WUR A;  2Z84 A;  2AGA A;  4MI7 A;  3RNV A;  3PRP A;  2UZJ A;  4OVZ A;  1DKI A;  4RF1 A;  4BOS A;  5EZS A;  3MJ5 A;  3PSE A;  2JRI A;  3PHX A;  3IFU A;  5EZQ A;  3TRK A;  4D8B A;  4R3D A;  5KO3 A;  1YZB A;  4OW0 A;  5E6J A;  3OQC A;  2J7Q C;  4IUM A;  4GUA A;  3PHW A;  2BTW B;  4ZTB A;  3BB7 A;  4M0W A;  3MTV A;  3E9S A;  2HWK A;  3PHU A;  4RNA A;  4D8E A;  4BOQ A;  4REZ A;  4A5U A;  1UKF A;  4BOU A;  4BOP A;  4RF0 A;  3W31 A;  4P16 A;  3W30 A;  5JZE A;  3O65 A;  4IP3 A;  2J7Q A;  2BTW A;  4D8I A;  4OVZ B;  3BY4 A;  3MP2 A;  2FE8 A;  1PVJ A;  4RKX A;  4XZX A;  3TMP A;  4HXD B;  3BBA A;  3ZNH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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