4D8IA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 81
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8iA00
1DKIA 2JTCA 3BBAA 2UZJA 4RKXA 4D8EA 4D8BA 3BB7A 1PVJA 4D8IA
chains in the Genus database with same CATH superfamily
1CTEA 1GCBA 1GECE 2FTDA 2GFOA 4X6HA 3KW9A 1AYUA 4PT5A 1ICFA 1YK8A 1AYWA 1VSNA 3OF9A 2JQFR 5JA7A 2YJ9A 1ZIVA 1ME3A 3PNRA 4A5UA 4RF1A 1KHPA 3C0RA 3CH3X 1PBHA 3ZUAA 1STFE 3IMAA 3H6SA 4P6EA 3V6EA 3H8CA 2DC8A 1QOLA 3WXEA 4DMXA 1NB3A 1UKFA 2OZ2A 1AU4A 3V6CA 4P16A 4WA6A 4BOPA 1EF7A 2DCDA 3P5VA 4Q8HA 1NLJA 2YJCA 4MM3B 3MHHA 3WXFA 4CDDB 2AYNA 2AUXA 1S4VA 1NL6A 1BP4A 5PADA 5KO3A 3QSDA 2G7YA 3PRPA 4XZXA 2P0RA 5CVNB 3E1ZB 3PHUA 4DMYA 4RY2A 3QJ3A 1KFUL 4YV8A 2J7QA 4X6IA 2F1GA 2CIOA 4W5CA 4BSQA 1AECA 4BPVA 2DCCA 1AU2A 2XU4A 1F29A 2NQAA 3KX1A 3ZNHA 4BOQA 1DKIA 1PADA 3IV2A 3F75A 3PSEA 4QRXA 1A6RA 4AXLA 5J94A 3LFYA 1TU6A 2AUZA 2FE8A 2YJBA 4I05A 1GLOA 1KHQA 3H7DA 5A24A 1AU0A 3N3GA 1BQIA 2DJFB 1AU3A 3N4CA 2OP3A 1ME4A 4D8EA 4N8WA 4M0WA 2YJ2A 4OW0A 5FPWA 3NHEA 4REZA 2G6DA 1YZBA 2B1NA 4XUIA 2VHSA 1MEMA 1PPNA 3PT2A 2HHNA 3MP2A 4P6GA 5CVMA 4BQVA 1PIPA 2C0YA 4ZTBA 2Y5BA 1MEGA 3S3RA 5K16A 2JRIA 2R9OA 5CVOB 3BB7A 2IBIA 1Y08A 2AGAA 5JZEA 4N79A 3OISA 1CPJA 4OELA 3S3QA 1M6DA 3GCBA 7PCKA 4PP2E 4GUAA 1EWMA 1MHWA 5EGWA 3HD3A 3M99A 5JH3A 1F2CA 3MTNA 2PADA 4XR7A 2BTWA 2OULA 3CBJA 2E02A 2G8JA 1NPZA 4YYUA 3PDFA 4D8BA 1CQDA 2J7QC 2DJGB 2H7JA 4FJCA 2DZZA 1KFXL 1ZCMA 1SP4B 3BBAA 3MORA 3MTVA 5CHTA 3QT4A 4CDCB 5EZSA 1TLOA 2PBHA 1PVJA 3RVVA 4CDFB 4RKXA 3PHXA 1YT7A 4BOSA 1TL9A 2B1MA 4G54A 3RVWA 2BDZA 2XU1A 3E9SA 1IWDA 1K3BB 1ATKA 2PNSA 3IEJA 4QRGA 2ATOA 4X6JA 2AU1A 2NQDB 4N4ZA 1PPPA 3D6SA 2BU3A 3C9EA 3PRMA 1EWOA 4MZOA 1CB5A 3HWNA 1CS8A 1PPDA 2IPPB 5EZQA 3OQCA 2AVWA 3PBHA 3IOQA 3AI8A 3B79A 3BY4A 2R6NA 3K24A 3BCNA 1ITOA 1Q6KA 4MZSA 2Y6EA 4I07A 3OVXA 3HHAA 2BTWB 4YYWA 4OVZA 1CVZA 8PCHA 3K9MA 1Y4HA 2UZJA 3P5XA 3TRKA 2HWKA 3IFUA 4BS5A 2P7UA 2DZYA 2R9CA 3RVXA 3H89A 4FIPA 4KLBA 1U9WA 1CSBB 4QBBA 4I04A 3O0UA 4FK5A 4CDEB 4Q8GA 1AIMA 1NB5A 4YYRA 4PP1A 2FT2A 4BS6A 1QXPA 3USVA 3WXGA 2R9FA 1YALA 4YYQA 1FH0A 2FO5A 1MDWA 4AXMA 4YYSA 2BDLA 2ARYA 3W31A 3TNXA 4YVAA 3LXSA 3PW3A 2DOSA 2FRQA 2HH5A 1U9XA 1EWPA 2DC9A 3RNVA 4PI3A 3H8BA 2NQIA 1YK7A 1MS6A 5F02A 3O1GA 4IP3A 4PADA 3PHWA 3BWKA 4HWYA 1JQPA 4OEMA 4IUMA 2HD5A 1QMYA 3F5VA 2AIMA 5EF4A 3KSEA 2XU3A 3I3TA 1PPOA 1EWLA 2Z84A 2E03A 3DF0A 4K7CA 1DEUA 2AS8A 3ERVA 2CB5A 4BOUA 3P5UA 1PCIA 3B21A 4OVZB 1BGOA 3IUTA 2E00A 4MSXA 1PXVA 1X9YA 2FUDA 2DC7A 3TMPA 3W30A 1SNKA 3BPFA 2WBFX 5E6JA 2F7DA 2VHFA 4W4UA 4RF0A 3P5WA 4ZUXU 2DCBA 1KXRA 3OVZA 4W5BA 1GMYA 1U9VA 9PAPA 4HXDB 3OF8A 1YVBA 3IHPA 2AYOA 1CJLA 2FYEA 2ACTA 3K8UA 4QH6A 3HHIA 3N3KA 4BOZA 3CBKA 2R9NA 2R9MA 5CHVA 1NQCA 1CV8A 4MI7A 3BOWA 1AYVA 2G8EA 1QDQA 4WURA 1U9QX 1VJVA 2JTCA 2YJ8A 3MHSA 1THEA 3MJ5A 3KWBX 1DF0A 3BC3A 4RNAA 2PREA 1POPA 1PE6A 2O6XA 2NQGA 3KFQA 1O0EA 2P86A 1XKGA 4R3DA 2FRAA 4CZWA 3BPMA 2DCAA 1MIRA 3CH2X 1F2BA 3U8EA 1F2AA 4YYVA 3O65A 3KWZA 2HXZA 1HUCB 2DC6A 1U5IA 2XU5A 3KKUA 4D8IA 2FQ9A 1BY8A 2GHUA 3I06A 6PADA 2E01A 2JQGR 4QRVA
chains in the Genus database with same CATH topology
4OW0A 2Z84A 2BU3A 4PT5A 4REZA 1YZBA 3PRMA 4BOUA 3B21A 5EZQA 3OQCA 4OVZB 3PT2A 3MP2A 3BY4A 4A5UA 4RF1A 3C0RA 3TMPA 3W30A 4ZTBA 2JRIA 5E6JA 3BB7A 4RF0A 2BTWB 4OVZA 2AGAA 1UKFA 5JZEA 2UZJA 4P16A 3TRKA 4BOPA 4HXDB 2HWKA 3IFUA 4GUAA 4MM3B 4BOZA 2BTWA 5KO3A 3PRPA 4XZXA 3PHUA 4D8BA 2J7QC 2J7QA 4MI7A 4WURA 2JTCA 3BBAA 3MJ5A 4RNAA 3MTVA 3ZNHA 4BOQA 5EZSA 1DKIA 3W31A 3PSEA 4R3DA 1PVJA 2DOSA 2FE8A 3RNVA 4RKXA 3O65A 3PHXA 4BOSA 4IP3A 3PHWA 3E9SA 4D8IA 4IUMA 4D8EA 4M0WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DKI A;  2JTC A;  3BBA A;  2UZJ A;  4RKX A;  4D8E A;  4D8B A;  3BB7 A;  1PVJ A;  4D8I A; 
#chains in the Genus database with same CATH topology
 1CTE A;  1GCB A;  1GEC E;  2FTD A;  2GFO A;  4X6H A;  3KW9 A;  1AYU A;  4PT5 A;  1ICF A;  1YK8 A;  1AYW A;  1VSN A;  3OF9 A;  2JQF R;  5JA7 A;  2YJ9 A;  1ZIV A;  1ME3 A;  3PNR A;  4A5U A;  4RF1 A;  1KHP A;  3C0R A;  3CH3 X;  1PBH A;  3ZUA A;  1STF E;  3IMA A;  3H6S A;  4P6E A;  3V6E A;  3H8C A;  2DC8 A;  1QOL A;  3WXE A;  4DMX A;  1NB3 A;  1UKF A;  2OZ2 A;  1AU4 A;  3V6C A;  4P16 A;  4WA6 A;  4BOP A;  1EF7 A;  2DCD A;  3P5V A;  4Q8H A;  1NLJ A;  2YJC A;  4MM3 B;  3MHH A;  3WXF A;  4CDD B;  2AYN A;  2AUX A;  1S4V A;  1NL6 A;  1BP4 A;  5PAD A;  5KO3 A;  3QSD A;  2G7Y A;  3PRP A;  4XZX A;  2P0R A;  5CVN B;  3E1Z B;  3PHU A;  4DMY A;  4RY2 A;  3QJ3 A;  1KFU L;  4YV8 A;  2J7Q A;  4X6I A;  2F1G A;  2CIO A;  4W5C A;  4BSQ A;  1AEC A;  4BPV A;  2DCC A;  1AU2 A;  2XU4 A;  1F29 A;  2NQA A;  3KX1 A;  3ZNH A;  4BOQ A;  1DKI A;  1PAD A;  3IV2 A;  3F75 A;  3PSE A;  4QRX A;  1A6R A;  4AXL A;  5J94 A;  3LFY A;  1TU6 A;  2AUZ A;  2FE8 A;  2YJB A;  4I05 A;  1GLO A;  1KHQ A;  3H7D A;  5A24 A;  1AU0 A;  3N3G A;  1BQI A;  2DJF B;  1AU3 A;  3N4C A;  2OP3 A;  1ME4 A;  4D8E A;  4N8W A;  4M0W A;  2YJ2 A;  4OW0 A;  5FPW A;  3NHE A;  4REZ A;  2G6D A;  1YZB A;  2B1N A;  4XUI A;  2VHS A;  1MEM A;  1PPN A;  3PT2 A;  2HHN A;  3MP2 A;  4P6G A;  5CVM A;  4BQV A;  1PIP A;  2C0Y A;  4ZTB A;  2Y5B A;  1MEG A;  3S3R A;  5K16 A;  2JRI A;  2R9O A;  5CVO B;  3BB7 A;  2IBI A;  1Y08 A;  2AGA A;  5JZE A;  4N79 A;  3OIS A;  1CPJ A;  4OEL A;  3S3Q A;  1M6D A;  3GCB A;  7PCK A;  4PP2 E;  4GUA A;  1EWM A;  1MHW A;  5EGW A;  3HD3 A;  3M99 A;  5JH3 A;  1F2C A;  3MTN A;  2PAD A;  4XR7 A;  2BTW A;  2OUL A;  3CBJ A;  2E02 A;  2G8J A;  1NPZ A;  4YYU A;  3PDF A;  4D8B A;  1CQD A;  2J7Q C;  2DJG B;  2H7J A;  4FJC A;  2DZZ A;  1KFX L;  1ZCM A;  1SP4 B;  3BBA A;  3MOR A;  3MTV A;  5CHT A;  3QT4 A;  4CDC B;  5EZS A;  1TLO A;  2PBH A;  1PVJ A;  3RVV A;  4CDF B;  4RKX A;  3PHX A;  1YT7 A;  4BOS A;  1TL9 A;  2B1M A;  4G54 A;  3RVW A;  2BDZ A;  2XU1 A;  3E9S A;  1IWD A;  1K3B B;  1ATK A;  2PNS A;  3IEJ A;  4QRG A;  2ATO A;  4X6J A;  2AU1 A;  2NQD B;  4N4Z A;  1PPP A;  3D6S A;  2BU3 A;  3C9E A;  3PRM A;  1EWO A;  4MZO A;  1CB5 A;  3HWN A;  1CS8 A;  1PPD A;  2IPP B;  5EZQ A;  3OQC A;  2AVW A;  3PBH A;  3IOQ A;  3AI8 A;  3B79 A;  3BY4 A;  2R6N A;  3K24 A;  3BCN A;  1ITO A;  1Q6K A;  4MZS A;  2Y6E A;  4I07 A;  3OVX A;  3HHA A;  2BTW B;  4YYW A;  4OVZ A;  1CVZ A;  8PCH A;  3K9M A;  1Y4H A;  2UZJ A;  3P5X A;  3TRK A;  2HWK A;  3IFU A;  4BS5 A;  2P7U A;  2DZY A;  2R9C A;  3RVX A;  3H89 A;  4FIP A;  4KLB A;  1U9W A;  1CSB B;  4QBB A;  4I04 A;  3O0U A;  4FK5 A;  4CDE B;  4Q8G A;  1AIM A;  1NB5 A;  4YYR A;  4PP1 A;  2FT2 A;  4BS6 A;  1QXP A;  3USV A;  3WXG A;  2R9F A;  1YAL A;  4YYQ A;  1FH0 A;  2FO5 A;  1MDW A;  4AXM A;  4YYS A;  2BDL A;  2ARY A;  3W31 A;  3TNX A;  4YVA A;  3LXS A;  3PW3 A;  2DOS A;  2FRQ A;  2HH5 A;  1U9X A;  1EWP A;  2DC9 A;  3RNV A;  4PI3 A;  3H8B A;  2NQI A;  1YK7 A;  1MS6 A;  5F02 A;  3O1G A;  4IP3 A;  4PAD A;  3PHW A;  3BWK A;  4HWY A;  1JQP A;  4OEM A;  4IUM A;  2HD5 A;  1QMY A;  3F5V A;  2AIM A;  5EF4 A;  3KSE A;  2XU3 A;  3I3T A;  1PPO A;  1EWL A;  2Z84 A;  2E03 A;  3DF0 A;  4K7C A;  1DEU A;  2AS8 A;  3ERV A;  2CB5 A;  4BOU A;  3P5U A;  1PCI A;  3B21 A;  4OVZ B;  1BGO A;  3IUT A;  2E00 A;  4MSX A;  1PXV A;  1X9Y A;  2FUD A;  2DC7 A;  3TMP A;  3W30 A;  1SNK A;  3BPF A;  2WBF X;  5E6J A;  2F7D A;  2VHF A;  4W4U A;  4RF0 A;  3P5W A;  4ZUX U;  2DCB A;  1KXR A;  3OVZ A;  4W5B A;  1GMY A;  1U9V A;  9PAP A;  4HXD B;  3OF8 A;  1YVB A;  3IHP A;  2AYO A;  1CJL A;  2FYE A;  2ACT A;  3K8U A;  4QH6 A;  3HHI A;  3N3K A;  4BOZ A;  3CBK A;  2R9N A;  2R9M A;  5CHV A;  1NQC A;  1CV8 A;  4MI7 A;  3BOW A;  1AYV A;  2G8E A;  1QDQ A;  4WUR A;  1U9Q X;  1VJV A;  2JTC A;  2YJ8 A;  3MHS A;  1THE A;  3MJ5 A;  3KWB X;  1DF0 A;  3BC3 A;  4RNA A;  2PRE A;  1POP A;  1PE6 A;  2O6X A;  2NQG A;  3KFQ A;  1O0E A;  2P86 A;  1XKG A;  4R3D A;  2FRA A;  4CZW A;  3BPM A;  2DCA A;  1MIR A;  3CH2 X;  1F2B A;  3U8E A;  1F2A A;  4YYV A;  3O65 A;  3KWZ A;  2HXZ A;  1HUC B;  2DC6 A;  1U5I A;  2XU5 A;  3KKU A;  4D8I A;  2FQ9 A;  1BY8 A;  2GHU A;  3I06 A;  6PAD A;  2E01 A;  2JQG R;  4QRV A; 
#chains in the Genus database with same CATH homology
 4OW0 A;  2Z84 A;  2BU3 A;  4PT5 A;  4REZ A;  1YZB A;  3PRM A;  4BOU A;  3B21 A;  5EZQ A;  3OQC A;  4OVZ B;  3PT2 A;  3MP2 A;  3BY4 A;  4A5U A;  4RF1 A;  3C0R A;  3TMP A;  3W30 A;  4ZTB A;  2JRI A;  5E6J A;  3BB7 A;  4RF0 A;  2BTW B;  4OVZ A;  2AGA A;  1UKF A;  5JZE A;  2UZJ A;  4P16 A;  3TRK A;  4BOP A;  4HXD B;  2HWK A;  3IFU A;  4GUA A;  4MM3 B;  4BOZ A;  2BTW A;  5KO3 A;  3PRP A;  4XZX A;  3PHU A;  4D8B A;  2J7Q C;  2J7Q A;  4MI7 A;  4WUR A;  2JTC A;  3BBA A;  3MJ5 A;  4RNA A;  3MTV A;  3ZNH A;  4BOQ A;  5EZS A;  1DKI A;  3W31 A;  3PSE A;  4R3D A;  1PVJ A;  2DOS A;  2FE8 A;  3RNV A;  4RKX A;  3O65 A;  3PHX A;  4BOS A;  4IP3 A;  3PHW A;  3E9S A;  4D8I A;  4IUM A;  4D8E A;  4M0W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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