2UZJA

Crystal structure of the mature streptococcal cysteine protease, mspeb
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
253
structure length
249
Chain Sequence
QPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGAGGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords STREPTOPAIN
publication title Structure of the Mature Streptococcal Cysteine Protease Exotoxin Mspeb in its Active Dimeric Form.
pubmed doi rcsb
total genus 79
structure length 249
sequence length 253
chains with identical sequence B
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2008-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2uzjA00
2JTCA 1PVJA 4RKXA 2UZJA 4D8EA 3BBAA 1DKIA 4D8BA 4D8IA 3BB7A
chains in the Genus database with same CATH superfamily
1NL6A 3PW3A 5J94A 1M6DA 3W31A 4D8IA 4HWYA 2NQIA 2R9CA 5CVNB 3I06A 4OEMA 2ARYA 1X9YA 2G8EA 1AYUA 3IUTA 3OQCA 4ZUXU 2DOSA 2VHSA 1ZCMA 1AU2A 1ATKA 3E9SA 4X6JA 6PADA 3MTVA 4OVZA 3RVWA 1QOLA 1AU0A 3PBHA 2O6XA 3V6EA 4GUAA 2R9FA 2HD5A 4OVZB 1EWOA 4REZA 3LXSA 1ME4A 3QJ3A 3PSEA 3CBJA 4BOSA 5PADA 4Q8HA 4W5BA 3S3RA 2P7UA 1EWLA 2AUZA 3H8BA 3B79A 2JRIA 3NHEA 4BOQA 1GCBA 3KW9A 1ME3A 3ZNHA 4XZXA 1MS6A 2R9MA 1PPOA 1KFXL 3V6CA 3HD3A 2NQAA 1STFE 2AYNA 2YJBA 5K16A 4W5CA 1TL9A 2E01A 2ACTA 1NPZA 3CBKA 4QRVA 5EF4A 2YJ2A 1TU6A 4YYRA 4PT5A 4D8BA 4I05A 2R9OA 3BPMA 3PRMA 4P16A 1BY8A 3KFQA 2JQFR 2B1MA 3RNVA 1CTEA 4X6HA 2PNSA 3E1ZB 3PNRA 3P5UA 4QRGA 5EGWA 3O1GA 1DF0A 1NLJA 1Y08A 2CB5A 5KO3A 2DZYA 1PPPA 4MI7A 4WURA 2DCBA 1PCIA 1Q6KA 2BDZA 3O65A 2BDLA 4MZSA 1F29A 2YJ8A 5CVOB 1CVZA 2J7QC 2AU1A 1MHWA 3KKUA 2Z84A 2E02A 3C9EA 3ERVA 2DJGB 1MIRA 5A24A 4QBBA 2HH5A 1QMYA 3WXFA 3WXEA 4YYUA 2YJ9A 2OP3A 2FT2A 2DC8A 3OVZA 4R3DA 1MEMA 2E03A 4RNAA 1PE6A 2VHFA 3BB7A 2FRQA 1KFUL 2FE8A 4BQVA 4RY2A 9PAPA 5JH3A 3IOQA 1U9QX 2FUDA 1NQCA 3PHUA 4N8WA 4OW0A 3U8EA 2AS8A 1TLOA 2B1NA 2G8JA 2JTCA 1POPA 1O0EA 4W4UA 1BP4A 2WBFX 2GFOA 1PADA 1ZIVA 3IFUA 2HWKA 4Q8GA 3RVVA 1FH0A 4N79A 7PCKA 1VJVA 3MHHA 4FK5A 1XKGA 4AXLA 3TNXA 3OF8A 5JZEA 2BTWA 2F1GA 1DEUA 4YYQA 4BSQA 2DC7A 2XU3A 5CHTA 4PP2E 3B21A 5CVMA 4BPVA 2YJCA 3BOWA 3K8UA 3OVXA 1AU4A 3O0UA 5CHVA 1NB5A 2JQGR 2BU3A 3BPFA 1ITOA 2P86A 1SP4B 1YT7A 3P5WA 4WA6A 3IMAA 2G6DA 4YYVA 3IHPA 3ZUAA 1QXPA 3CH2X 3H89A 4FIPA 2DJFB 4OELA 4DMYA 1PXVA 3K24A 1YZBA 2AGAA 4BOUA 4RF1A 1YALA 2NQDB 2E00A 2AVWA 2DC9A 3M99A 2DC6A 1JQPA 4YVAA 2FTDA 3IEJA 4YYWA 3H8CA 2IPPB 1U9WA 1KXRA 4A5UA 1UKFA 2CIOA 1VSNA 3BC3A 1A6RA 3N3KA 3HHAA 2DZZA 3H6SA 5F02A 1ICFA 2PBHA 1PPNA 3I3TA 3P5VA 4YV8A 1CV8A 4G54A 3MP2A 4MZOA 3RVXA 3MTNA 1PVJA 1EF7A 3PHXA 5EZSA 2GHUA 4P6GA 1AYWA 8PCHA 2Y5BA 3MORA 1U9VA 2H7JA 3MJ5A 3TMPA 3N3GA 1BGOA 2FRAA 4X6IA 1KHQA 5EZQA 4FJCA 2HHNA 4CDFB 2DCCA 2XU4A 3F75A 1K3BB 2ATOA 1YK7A 2UZJA 2FYEA 1Y4HA 2HXZA 3HHIA 2AYOA 4BOPA 3IV2A 1AU3A 1HUCB 1NB3A 4PP1A 1CS8A 3WXGA 2G7YA 3N4CA 4IP3A 4MSXA 2OULA 1CSBB 4BOZA 4CDDB 3TRKA 3PRPA 3OF9A 3KX1A 4IUMA 1AECA 3LFYA 4PI3A 3CH3X 3PDFA 4MM3B 4YYSA 3DF0A 3MHSA 1YVBA 4KLBA 2FQ9A 2PREA 2BTWB 3P5XA 1EWMA 3KWBX 1S4VA 4QRXA 3F5VA 1MDWA 2R9NA 3QT4A 3USVA 4CDCB 4I07A 1PPDA 1EWPA 4BS5A 3K9MA 1THEA 4XR7A 4BS6A 1IWDA 3W30A 1GLOA 4N4ZA 2XU5A 3C0RA 1F2BA 1U5IA 3AI8A 1PBHA 1GECE 1GMYA 2DCAA 4XUIA 1F2AA 2AIMA 4I04A 1AIMA 1CJLA 3QSDA 1DKIA 5FPWA 1MEGA 2C0YA 2J7QA 3PHWA 4CZWA 3BCNA 2FO5A 4RKXA 1F2CA 4QH6A 4P6EA 2IBIA 4M0WA 4DMXA 2F7DA 3D6SA 3BBAA 2P0RA 1SNKA 2AUXA 4PADA 3S3QA 3KSEA 2Y6EA 4K7CA 1YK8A 4CDEB 2XU1A 4RF0A 1BQIA 2DCDA 3PT2A 3BY4A 1U9XA 2R6NA 5JA7A 1PIPA 4D8EA 3KWZA 4ZTBA 2OZ2A 3BWKA 1AYVA 3HWNA 1CB5A 1KHPA 3H7DA 3OISA 1CQDA 5E6JA 4AXMA 1QDQA 3GCBA 2NQGA 1CPJA 2PADA 4HXDB
chains in the Genus database with same CATH topology
4IUMA 3W31A 4MI7A 4WURA 4D8IA 3O65A 4MM3B 2J7QC 3OQCA 2BU3A 2DOSA 2Z84A 3E9SA 2BTWB 3MTVA 4OVZA 2AGAA 1YZBA 4BOUA 4RF1A 4GUAA 4R3DA 4OVZB 4REZA 4RNAA 3PSEA 3BB7A 3W30A 4BOSA 2FE8A 3C0RA 3PHUA 4A5UA 4OW0A 1UKFA 2JRIA 4BOQA 3ZNHA 2JTCA 4XZXA 1DKIA 2J7QA 3PHWA 3MP2A 1PVJA 4RKXA 3PHXA 5EZSA 4M0WA 3BBAA 3IFUA 2HWKA 3MJ5A 3TMPA 4PT5A 4D8BA 5EZQA 4RF0A 3PRMA 4P16A 5JZEA 3PT2A 3BY4A 2BTWA 3RNVA 2UZJA 4D8EA 4ZTBA 4BOPA 3B21A 5E6JA 4IP3A 4BOZA 3TRKA 5KO3A 3PRPA 4HXDB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JTC A;  1PVJ A;  4RKX A;  2UZJ A;  4D8E A;  3BBA A;  1DKI A;  4D8B A;  4D8I A;  3BB7 A; 
#chains in the Genus database with same CATH topology
 1NL6 A;  3PW3 A;  5J94 A;  1M6D A;  3W31 A;  4D8I A;  4HWY A;  2NQI A;  2R9C A;  5CVN B;  3I06 A;  4OEM A;  2ARY A;  1X9Y A;  2G8E A;  1AYU A;  3IUT A;  3OQC A;  4ZUX U;  2DOS A;  2VHS A;  1ZCM A;  1AU2 A;  1ATK A;  3E9S A;  4X6J A;  6PAD A;  3MTV A;  4OVZ A;  3RVW A;  1QOL A;  1AU0 A;  3PBH A;  2O6X A;  3V6E A;  4GUA A;  2R9F A;  2HD5 A;  4OVZ B;  1EWO A;  4REZ A;  3LXS A;  1ME4 A;  3QJ3 A;  3PSE A;  3CBJ A;  4BOS A;  5PAD A;  4Q8H A;  4W5B A;  3S3R A;  2P7U A;  1EWL A;  2AUZ A;  3H8B A;  3B79 A;  2JRI A;  3NHE A;  4BOQ A;  1GCB A;  3KW9 A;  1ME3 A;  3ZNH A;  4XZX A;  1MS6 A;  2R9M A;  1PPO A;  1KFX L;  3V6C A;  3HD3 A;  2NQA A;  1STF E;  2AYN A;  2YJB A;  5K16 A;  4W5C A;  1TL9 A;  2E01 A;  2ACT A;  1NPZ A;  3CBK A;  4QRV A;  5EF4 A;  2YJ2 A;  1TU6 A;  4YYR A;  4PT5 A;  4D8B A;  4I05 A;  2R9O A;  3BPM A;  3PRM A;  4P16 A;  1BY8 A;  3KFQ A;  2JQF R;  2B1M A;  3RNV A;  1CTE A;  4X6H A;  2PNS A;  3E1Z B;  3PNR A;  3P5U A;  4QRG A;  5EGW A;  3O1G A;  1DF0 A;  1NLJ A;  1Y08 A;  2CB5 A;  5KO3 A;  2DZY A;  1PPP A;  4MI7 A;  4WUR A;  2DCB A;  1PCI A;  1Q6K A;  2BDZ A;  3O65 A;  2BDL A;  4MZS A;  1F29 A;  2YJ8 A;  5CVO B;  1CVZ A;  2J7Q C;  2AU1 A;  1MHW A;  3KKU A;  2Z84 A;  2E02 A;  3C9E A;  3ERV A;  2DJG B;  1MIR A;  5A24 A;  4QBB A;  2HH5 A;  1QMY A;  3WXF A;  3WXE A;  4YYU A;  2YJ9 A;  2OP3 A;  2FT2 A;  2DC8 A;  3OVZ A;  4R3D A;  1MEM A;  2E03 A;  4RNA A;  1PE6 A;  2VHF A;  3BB7 A;  2FRQ A;  1KFU L;  2FE8 A;  4BQV A;  4RY2 A;  9PAP A;  5JH3 A;  3IOQ A;  1U9Q X;  2FUD A;  1NQC A;  3PHU A;  4N8W A;  4OW0 A;  3U8E A;  2AS8 A;  1TLO A;  2B1N A;  2G8J A;  2JTC A;  1POP A;  1O0E A;  4W4U A;  1BP4 A;  2WBF X;  2GFO A;  1PAD A;  1ZIV A;  3IFU A;  2HWK A;  4Q8G A;  3RVV A;  1FH0 A;  4N79 A;  7PCK A;  1VJV A;  3MHH A;  4FK5 A;  1XKG A;  4AXL A;  3TNX A;  3OF8 A;  5JZE A;  2BTW A;  2F1G A;  1DEU A;  4YYQ A;  4BSQ A;  2DC7 A;  2XU3 A;  5CHT A;  4PP2 E;  3B21 A;  5CVM A;  4BPV A;  2YJC A;  3BOW A;  3K8U A;  3OVX A;  1AU4 A;  3O0U A;  5CHV A;  1NB5 A;  2JQG R;  2BU3 A;  3BPF A;  1ITO A;  2P86 A;  1SP4 B;  1YT7 A;  3P5W A;  4WA6 A;  3IMA A;  2G6D A;  4YYV A;  3IHP A;  3ZUA A;  1QXP A;  3CH2 X;  3H89 A;  4FIP A;  2DJF B;  4OEL A;  4DMY A;  1PXV A;  3K24 A;  1YZB A;  2AGA A;  4BOU A;  4RF1 A;  1YAL A;  2NQD B;  2E00 A;  2AVW A;  2DC9 A;  3M99 A;  2DC6 A;  1JQP A;  4YVA A;  2FTD A;  3IEJ A;  4YYW A;  3H8C A;  2IPP B;  1U9W A;  1KXR A;  4A5U A;  1UKF A;  2CIO A;  1VSN A;  3BC3 A;  1A6R A;  3N3K A;  3HHA A;  2DZZ A;  3H6S A;  5F02 A;  1ICF A;  2PBH A;  1PPN A;  3I3T A;  3P5V A;  4YV8 A;  1CV8 A;  4G54 A;  3MP2 A;  4MZO A;  3RVX A;  3MTN A;  1PVJ A;  1EF7 A;  3PHX A;  5EZS A;  2GHU A;  4P6G A;  1AYW A;  8PCH A;  2Y5B A;  3MOR A;  1U9V A;  2H7J A;  3MJ5 A;  3TMP A;  3N3G A;  1BGO A;  2FRA A;  4X6I A;  1KHQ A;  5EZQ A;  4FJC A;  2HHN A;  4CDF B;  2DCC A;  2XU4 A;  3F75 A;  1K3B B;  2ATO A;  1YK7 A;  2UZJ A;  2FYE A;  1Y4H A;  2HXZ A;  3HHI A;  2AYO A;  4BOP A;  3IV2 A;  1AU3 A;  1HUC B;  1NB3 A;  4PP1 A;  1CS8 A;  3WXG A;  2G7Y A;  3N4C A;  4IP3 A;  4MSX A;  2OUL A;  1CSB B;  4BOZ A;  4CDD B;  3TRK A;  3PRP A;  3OF9 A;  3KX1 A;  4IUM A;  1AEC A;  3LFY A;  4PI3 A;  3CH3 X;  3PDF A;  4MM3 B;  4YYS A;  3DF0 A;  3MHS A;  1YVB A;  4KLB A;  2FQ9 A;  2PRE A;  2BTW B;  3P5X A;  1EWM A;  3KWB X;  1S4V A;  4QRX A;  3F5V A;  1MDW A;  2R9N A;  3QT4 A;  3USV A;  4CDC B;  4I07 A;  1PPD A;  1EWP A;  4BS5 A;  3K9M A;  1THE A;  4XR7 A;  4BS6 A;  1IWD A;  3W30 A;  1GLO A;  4N4Z A;  2XU5 A;  3C0R A;  1F2B A;  1U5I A;  3AI8 A;  1PBH A;  1GEC E;  1GMY A;  2DCA A;  4XUI A;  1F2A A;  2AIM A;  4I04 A;  1AIM A;  1CJL A;  3QSD A;  1DKI A;  5FPW A;  1MEG A;  2C0Y A;  2J7Q A;  3PHW A;  4CZW A;  3BCN A;  2FO5 A;  4RKX A;  1F2C A;  4QH6 A;  4P6E A;  2IBI A;  4M0W A;  4DMX A;  2F7D A;  3D6S A;  3BBA A;  2P0R A;  1SNK A;  2AUX A;  4PAD A;  3S3Q A;  3KSE A;  2Y6E A;  4K7C A;  1YK8 A;  4CDE B;  2XU1 A;  4RF0 A;  1BQI A;  2DCD A;  3PT2 A;  3BY4 A;  1U9X A;  2R6N A;  5JA7 A;  1PIP A;  4D8E A;  3KWZ A;  4ZTB A;  2OZ2 A;  3BWK A;  1AYV A;  3HWN A;  1CB5 A;  1KHP A;  3H7D A;  3OIS A;  1CQD A;  5E6J A;  4AXM A;  1QDQ A;  3GCB A;  2NQG A;  1CPJ A;  2PAD A;  4HXD B; 
#chains in the Genus database with same CATH homology
 4IUM A;  3W31 A;  4MI7 A;  4WUR A;  4D8I A;  3O65 A;  4MM3 B;  2J7Q C;  3OQC A;  2BU3 A;  2DOS A;  2Z84 A;  3E9S A;  2BTW B;  3MTV A;  4OVZ A;  2AGA A;  1YZB A;  4BOU A;  4RF1 A;  4GUA A;  4R3D A;  4OVZ B;  4REZ A;  4RNA A;  3PSE A;  3BB7 A;  3W30 A;  4BOS A;  2FE8 A;  3C0R A;  3PHU A;  4A5U A;  4OW0 A;  1UKF A;  2JRI A;  4BOQ A;  3ZNH A;  2JTC A;  4XZX A;  1DKI A;  2J7Q A;  3PHW A;  3MP2 A;  1PVJ A;  4RKX A;  3PHX A;  5EZS A;  4M0W A;  3BBA A;  3IFU A;  2HWK A;  3MJ5 A;  3TMP A;  4PT5 A;  4D8B A;  5EZQ A;  4RF0 A;  3PRM A;  4P16 A;  5JZE A;  3PT2 A;  3BY4 A;  2BTW A;  3RNV A;  2UZJ A;  4D8E A;  4ZTB A;  4BOP A;  3B21 A;  5E6J A;  4IP3 A;  4BOZ A;  3TRK A;  5KO3 A;  3PRP A;  4HXD B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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