2UZJA

Crystal structure of the mature streptococcal cysteine protease, mspeb
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
253
structure length
249
Chain Sequence
QPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGAGGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Mature Streptococcal Cysteine Protease Exotoxin Mspeb in its Active Dimeric Form.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STREPTOPAIN
total genus 79
structure length 249
sequence length 253
chains with identical sequence B
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2008-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2uzjA00
4D8BA 1DKIA 2UZJA 4RKXA 3BBAA 3BB7A 1PVJA 4D8EA 4D8IA 2JTCA
chains in the Genus database with same CATH superfamily
3QSDA 1PIPA 4PADA 3DF0A 4P6EA 4QH6A 2DC6A 3IHPA 2NQAA 3KWBX 1U9XA 5J94A 4CDFB 2AUXA 2PNSA 8PCHA 3CH3X 4AXMA 2B1MA 4YV8A 1EWPA 3P5UA 4D8EA 1THEA 4QRXA 1TL9A 1SP4B 2JQGR 2BU3A 3KSEA 3N3GA 3N3KA 4OVZA 3HHIA 2AUZA 2E00A 4N8WA 3PDFA 4W4UA 1VSNA 4RF0A 1YK8A 4X6JA 4OVZB 4BQVA 3N4CA 2NQGA 5JH3A 1POPA 2AU1A 1ZCMA 3BOWA 2JQFR 2NQDB 3PW3A 3S3QA 3RVVA 1TU6A 1F2BA 4BS5A 4BOUA 2CB5A 3E9SA 4RY2A 1KXRA 3RVWA 4YYUA 2JTCA 4PT5A 2Y5BA 2PBHA 2CIOA 2FT2A 4HWYA 4REZA 4XR7A 2ATOA 4FIPA 5K16A 4MI7A 4CDEB 4N79A 4FK5A 1EF7A 1KHQA 3I06A 2DCAA 1U9QX 5EF4A 3U8EA 1U9VA 3E1ZB 2PREA 3AI8A 3IV2A 1M6DA 1YALA 4IP3A 3OQCA 3RVXA 4K7CA 2ACTA 2UZJA 4ZTBA 5F02A 1DF0A 5EZQA 4X6IA 4YYVA 1YZBA 2OULA 2P7UA 2R9CA 5EGWA 1DKIA 3MHSA 2AIMA 1TLOA 1QOLA 2NQIA 1S4VA 3KW9A 3BPFA 4YYQA 1ZIVA 3OF8A 1CTEA 1CQDA 2BDZA 1GMYA 1JQPA 2G6DA 1KFUL 2DOSA 2FTDA 3MJ5A 2DCDA 4XUIA 1NB5A 4YYSA 5CHVA 4RF1A 2VHSA 4BOZA 1PVJA 2G8EA 4MZOA 2BDLA 3W30A 1CPJA 1QMYA 1BGOA 3K24A 1AYUA 4QRGA 4AXLA 4DMXA 1NL6A 1VJVA 3B79A 4OW0A 1AU2A 1PADA 1STFE 3BPMA 1Q6KA 4I04A 1BP4A 2R9OA 3IOQA 3WXEA 2E02A 2YJCA 3BY4A 2G8JA 3MTNA 3TRKA 4P16A 5CVOB 3OISA 4W5CA 2ARYA 4PP1A 1U5IA 1NLJA 2YJ9A 3WXFA 1O0EA 4BOQA 5A24A 1PPDA 1U9WA 2BTWA 1NPZA 2B1NA 4DMYA 3H8BA 3LXSA 1EWLA 1KHPA 1PXVA 2BTWB 2R9NA 2FRAA 3OF9A 1PCIA 3C9EA 5KO3A 9PAPA 2AYNA 1F2AA 1Y08A 2C0YA 3H6SA 2P86A 3PRPA 1MIRA 2FUDA 2OP3A 2IPPB 3K8UA 1ITOA 3QT4A 2DCBA 1PPPA 3BC3A 1F29A 4YVAA 1PPOA 3HHAA 3RNVA 2DC9A 3K9MA 5JA7A 3W31A 1PPNA 1MEGA 2F7DA 3IUTA 4BSQA 3O1GA 2HHNA 3P5VA 1FH0A 3BCNA 1AECA 2HH5A 2AGAA 4CZWA 4RNAA 1QDQA 3PHUA 4XZXA 4BOSA 1GLOA 4MZSA 3TNXA 2DJGB 4P6GA 3ERVA 1PE6A 2FQ9A 2GHUA 5JZEA 3MTVA 4QRVA 3USVA 3MP2A 3BB7A 1A6RA 1DEUA 1CB5A 4Q8GA 1AU4A 1PBHA 3KKUA 3H7DA 3I3TA 3QJ3A 4ZUXU 2GFOA 2XU5A 2P0RA 4I05A 1AU3A 1QXPA 3B21A 2O6XA 3ZNHA 1SNKA 4X6HA 4KLBA 1CSBB 4A5UA 1GCBA 1ME3A 1ME4A 3HD3A 4QBBA 1BY8A 3IFUA 3BWKA 4GUAA 3OVXA 4D8BA 5EZSA 4CDCB 2DJFB 4YYWA 5FPWA 5CVNB 4BS6A 2XU1A 1K3BB 3PHXA 3WXGA 3LFYA 2DC7A 2XU4A 3H8CA 2FYEA 3GCBA 2J7QA 3H89A 4R3DA 1YK7A 3M99A 3KWZA 2E01A 2R9MA 4N4ZA 3PHWA 2YJBA 4G54A 4WA6A 3BBAA 2DC8A 5PADA 3O65A 1AYVA 1Y4HA 3CH2X 3V6CA 4PI3A 3F5VA 2HD5A 3MORA 2R6NA 2J7QC 2AS8A 2WBFX 2YJ2A 1NB3A 1MS6A 1AYWA 1IWDA 1NQCA 3D6SA 3TMPA 2R9FA 2OZ2A 2G7YA 4MM3B 5CHTA 2DCCA 2AYOA 4YYRA 1BQIA 4W5BA 1CVZA 3PT2A 1AIMA 1CJLA 4RKXA 1F2CA 4CDDB 1ATKA 2XU3A 3IEJA 2VHFA 3PNRA 1X9YA 4I07A 3PSEA 2FO5A 1ICFA 2AVWA 2Z84A 7PCKA 2H7JA 3S3RA 3ZUAA 3C0RA 3CBKA 2E03A 1MDWA 4OEMA 2FRQA 4BPVA 4BOPA 1KFXL 3PBHA 4OELA 2FE8A 2DZZA 3OVZA 4IUMA 2F1GA 2HXZA 3P5XA 3PRMA 2YJ8A 6PADA 5CVMA 1GECE 4MSXA 1AU0A 1EWMA 1HUCB 1UKFA 3CBJA 2Y6EA 2DZYA 1EWOA 3KX1A 2JRIA 4HXDB 2HWKA 3MHHA 4M0WA 3NHEA 3HWNA 4Q8HA 1YT7A 3IMAA 3V6EA 2IBIA 1XKGA 2PADA 3O0UA 4D8IA 3F75A 1CS8A 3KFQA 4PP2E 1MEMA 3P5WA 4FJCA 4WURA 1CV8A 1YVBA 1MHWA 5E6JA
chains in the Genus database with same CATH topology
3PHWA 3BBAA 3RNVA 3O65A 3W31A 2J7QC 2DOSA 4D8EA 3MJ5A 4RF1A 2AGAA 4RNAA 3TMPA 2BU3A 4BOZA 1PVJA 4MM3B 4OVZA 3W30A 3PHUA 4XZXA 4BOSA 4RF0A 3PT2A 4OVZB 4RKXA 4OW0A 3PSEA 5JZEA 3MTVA 3MP2A 2Z84A 3BB7A 3C0RA 4BOUA 3E9SA 3BY4A 4BOPA 3TRKA 2JTCA 4PT5A 4P16A 2FE8A 4IUMA 4REZA 3PRMA 4MI7A 1UKFA 4BOQA 3B21A 3ZNHA 2BTWA 2JRIA 4HXDB 4A5UA 2HWKA 4M0WA 4IP3A 3IFUA 4GUAA 2BTWB 4D8BA 3OQCA 5EZSA 4ZTBA 2UZJA 5EZQA 4D8IA 5KO3A 1YZBA 3PHXA 4WURA 2J7QA 4R3DA 1DKIA 3PRPA 5E6JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8B A;  1DKI A;  2UZJ A;  4RKX A;  3BBA A;  3BB7 A;  1PVJ A;  4D8E A;  4D8I A;  2JTC A; 
#chains in the Genus database with same CATH topology
 3QSD A;  1PIP A;  4PAD A;  3DF0 A;  4P6E A;  4QH6 A;  2DC6 A;  3IHP A;  2NQA A;  3KWB X;  1U9X A;  5J94 A;  4CDF B;  2AUX A;  2PNS A;  8PCH A;  3CH3 X;  4AXM A;  2B1M A;  4YV8 A;  1EWP A;  3P5U A;  4D8E A;  1THE A;  4QRX A;  1TL9 A;  1SP4 B;  2JQG R;  2BU3 A;  3KSE A;  3N3G A;  3N3K A;  4OVZ A;  3HHI A;  2AUZ A;  2E00 A;  4N8W A;  3PDF A;  4W4U A;  1VSN A;  4RF0 A;  1YK8 A;  4X6J A;  4OVZ B;  4BQV A;  3N4C A;  2NQG A;  5JH3 A;  1POP A;  2AU1 A;  1ZCM A;  3BOW A;  2JQF R;  2NQD B;  3PW3 A;  3S3Q A;  3RVV A;  1TU6 A;  1F2B A;  4BS5 A;  4BOU A;  2CB5 A;  3E9S A;  4RY2 A;  1KXR A;  3RVW A;  4YYU A;  2JTC A;  4PT5 A;  2Y5B A;  2PBH A;  2CIO A;  2FT2 A;  4HWY A;  4REZ A;  4XR7 A;  2ATO A;  4FIP A;  5K16 A;  4MI7 A;  4CDE B;  4N79 A;  4FK5 A;  1EF7 A;  1KHQ A;  3I06 A;  2DCA A;  1U9Q X;  5EF4 A;  3U8E A;  1U9V A;  3E1Z B;  2PRE A;  3AI8 A;  3IV2 A;  1M6D A;  1YAL A;  4IP3 A;  3OQC A;  3RVX A;  4K7C A;  2ACT A;  2UZJ A;  4ZTB A;  5F02 A;  1DF0 A;  5EZQ A;  4X6I A;  4YYV A;  1YZB A;  2OUL A;  2P7U A;  2R9C A;  5EGW A;  1DKI A;  3MHS A;  2AIM A;  1TLO A;  1QOL A;  2NQI A;  1S4V A;  3KW9 A;  3BPF A;  4YYQ A;  1ZIV A;  3OF8 A;  1CTE A;  1CQD A;  2BDZ A;  1GMY A;  1JQP A;  2G6D A;  1KFU L;  2DOS A;  2FTD A;  3MJ5 A;  2DCD A;  4XUI A;  1NB5 A;  4YYS A;  5CHV A;  4RF1 A;  2VHS A;  4BOZ A;  1PVJ A;  2G8E A;  4MZO A;  2BDL A;  3W30 A;  1CPJ A;  1QMY A;  1BGO A;  3K24 A;  1AYU A;  4QRG A;  4AXL A;  4DMX A;  1NL6 A;  1VJV A;  3B79 A;  4OW0 A;  1AU2 A;  1PAD A;  1STF E;  3BPM A;  1Q6K A;  4I04 A;  1BP4 A;  2R9O A;  3IOQ A;  3WXE A;  2E02 A;  2YJC A;  3BY4 A;  2G8J A;  3MTN A;  3TRK A;  4P16 A;  5CVO B;  3OIS A;  4W5C A;  2ARY A;  4PP1 A;  1U5I A;  1NLJ A;  2YJ9 A;  3WXF A;  1O0E A;  4BOQ A;  5A24 A;  1PPD A;  1U9W A;  2BTW A;  1NPZ A;  2B1N A;  4DMY A;  3H8B A;  3LXS A;  1EWL A;  1KHP A;  1PXV A;  2BTW B;  2R9N A;  2FRA A;  3OF9 A;  1PCI A;  3C9E A;  5KO3 A;  9PAP A;  2AYN A;  1F2A A;  1Y08 A;  2C0Y A;  3H6S A;  2P86 A;  3PRP A;  1MIR A;  2FUD A;  2OP3 A;  2IPP B;  3K8U A;  1ITO A;  3QT4 A;  2DCB A;  1PPP A;  3BC3 A;  1F29 A;  4YVA A;  1PPO A;  3HHA A;  3RNV A;  2DC9 A;  3K9M A;  5JA7 A;  3W31 A;  1PPN A;  1MEG A;  2F7D A;  3IUT A;  4BSQ A;  3O1G A;  2HHN A;  3P5V A;  1FH0 A;  3BCN A;  1AEC A;  2HH5 A;  2AGA A;  4CZW A;  4RNA A;  1QDQ A;  3PHU A;  4XZX A;  4BOS A;  1GLO A;  4MZS A;  3TNX A;  2DJG B;  4P6G A;  3ERV A;  1PE6 A;  2FQ9 A;  2GHU A;  5JZE A;  3MTV A;  4QRV A;  3USV A;  3MP2 A;  3BB7 A;  1A6R A;  1DEU A;  1CB5 A;  4Q8G A;  1AU4 A;  1PBH A;  3KKU A;  3H7D A;  3I3T A;  3QJ3 A;  4ZUX U;  2GFO A;  2XU5 A;  2P0R A;  4I05 A;  1AU3 A;  1QXP A;  3B21 A;  2O6X A;  3ZNH A;  1SNK A;  4X6H A;  4KLB A;  1CSB B;  4A5U A;  1GCB A;  1ME3 A;  1ME4 A;  3HD3 A;  4QBB A;  1BY8 A;  3IFU A;  3BWK A;  4GUA A;  3OVX A;  4D8B A;  5EZS A;  4CDC B;  2DJF B;  4YYW A;  5FPW A;  5CVN B;  4BS6 A;  2XU1 A;  1K3B B;  3PHX A;  3WXG A;  3LFY A;  2DC7 A;  2XU4 A;  3H8C A;  2FYE A;  3GCB A;  2J7Q A;  3H89 A;  4R3D A;  1YK7 A;  3M99 A;  3KWZ A;  2E01 A;  2R9M A;  4N4Z A;  3PHW A;  2YJB A;  4G54 A;  4WA6 A;  3BBA A;  2DC8 A;  5PAD A;  3O65 A;  1AYV A;  1Y4H A;  3CH2 X;  3V6C A;  4PI3 A;  3F5V A;  2HD5 A;  3MOR A;  2R6N A;  2J7Q C;  2AS8 A;  2WBF X;  2YJ2 A;  1NB3 A;  1MS6 A;  1AYW A;  1IWD A;  1NQC A;  3D6S A;  3TMP A;  2R9F A;  2OZ2 A;  2G7Y A;  4MM3 B;  5CHT A;  2DCC A;  2AYO A;  4YYR A;  1BQI A;  4W5B A;  1CVZ A;  3PT2 A;  1AIM A;  1CJL A;  4RKX A;  1F2C A;  4CDD B;  1ATK A;  2XU3 A;  3IEJ A;  2VHF A;  3PNR A;  1X9Y A;  4I07 A;  3PSE A;  2FO5 A;  1ICF A;  2AVW A;  2Z84 A;  7PCK A;  2H7J A;  3S3R A;  3ZUA A;  3C0R A;  3CBK A;  2E03 A;  1MDW A;  4OEM A;  2FRQ A;  4BPV A;  4BOP A;  1KFX L;  3PBH A;  4OEL A;  2FE8 A;  2DZZ A;  3OVZ A;  4IUM A;  2F1G A;  2HXZ A;  3P5X A;  3PRM A;  2YJ8 A;  6PAD A;  5CVM A;  1GEC E;  4MSX A;  1AU0 A;  1EWM A;  1HUC B;  1UKF A;  3CBJ A;  2Y6E A;  2DZY A;  1EWO A;  3KX1 A;  2JRI A;  4HXD B;  2HWK A;  3MHH A;  4M0W A;  3NHE A;  3HWN A;  4Q8H A;  1YT7 A;  3IMA A;  3V6E A;  2IBI A;  1XKG A;  2PAD A;  3O0U A;  4D8I A;  3F75 A;  1CS8 A;  3KFQ A;  4PP2 E;  1MEM A;  3P5W A;  4FJC A;  4WUR A;  1CV8 A;  1YVB A;  1MHW A;  5E6J A; 
#chains in the Genus database with same CATH homology
 3PHW A;  3BBA A;  3RNV A;  3O65 A;  3W31 A;  2J7Q C;  2DOS A;  4D8E A;  3MJ5 A;  4RF1 A;  2AGA A;  4RNA A;  3TMP A;  2BU3 A;  4BOZ A;  1PVJ A;  4MM3 B;  4OVZ A;  3W30 A;  3PHU A;  4XZX A;  4BOS A;  4RF0 A;  3PT2 A;  4OVZ B;  4RKX A;  4OW0 A;  3PSE A;  5JZE A;  3MTV A;  3MP2 A;  2Z84 A;  3BB7 A;  3C0R A;  4BOU A;  3E9S A;  3BY4 A;  4BOP A;  3TRK A;  2JTC A;  4PT5 A;  4P16 A;  2FE8 A;  4IUM A;  4REZ A;  3PRM A;  4MI7 A;  1UKF A;  4BOQ A;  3B21 A;  3ZNH A;  2BTW A;  2JRI A;  4HXD B;  4A5U A;  2HWK A;  4M0W A;  4IP3 A;  3IFU A;  4GUA A;  2BTW B;  4D8B A;  3OQC A;  5EZS A;  4ZTB A;  2UZJ A;  5EZQ A;  4D8I A;  5KO3 A;  1YZB A;  3PHX A;  4WUR A;  2J7Q A;  4R3D A;  1DKI A;  3PRP A;  5E6J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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