2UZJA

Crystal structure of the mature streptococcal cysteine protease, mspeb
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
253
structure length
249
Chain Sequence
QPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGAGGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords STREPTOPAIN
publication title Structure of the Mature Streptococcal Cysteine Protease Exotoxin Mspeb in its Active Dimeric Form.
pubmed doi rcsb
molecule tags Hydrolase
total genus 79
structure length 249
sequence length 253
chains with identical sequence B
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2008-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2uzjA00
1DKIA 2UZJA 4D8EA 3BB7A 3BBAA 2JTCA 4RKXA 1PVJA 4D8IA 4D8BA
chains in the Genus database with same CATH superfamily
1AU0A 3PHWA 1GCBA 4BOSA 1F29A 1CVZA 2FRAA 3B79A 4GUAA 3P5UA 2FUDA 3PHXA 3H6SA 3PHUA 1KHPA 2YJ2A 1TU6A 1PPDA 2O6XA 4BOQA 3PSEA 4ZTBA 3RVVA 1TLOA 1ME3A 2DZYA 1MIRA 4YYQA 2DOSA 5JA7A 4BS5A 2J7QA 1GECE 3OISA 3OVXA 6PADA 4Q8GA 1A6RA 1DEUA 2ARYA 3IFUA 3LFYA 4KLBA 2IPPB 4PADA 1PIPA 3I06A 2DC7A 3USVA 4YYRA 1TL9A 4OELA 4BPVA 1EWPA 1ATKA 2C0YA 5E6JA 3CH3X 3OF8A 4BQVA 3PRPA 2BTWB 3OVZA 1FH0A 4RKXA 4A5UA 3O65A 3CBJA 1AU3A 5J94A 4W5BA 3BBAA 4N8WA 3MJ5A 4BOPA 4DMYA 3IOQA 4YYVA 3H7DA 1EWMA 4OW0A 5EGWA 1U9WA 4QRXA 4FJCA 1NB3A 4WA6A 2UZJA 2YJCA 5A24A 4X6IA 2DZZA 2DCAA 2PADA 2HWKA 3TNXA 4PT5A 2E03A 4N79A 4OVZB 2FO5A 5K16A 3PNRA 2AYOA 2AUZA 1KFXL 3K9MA 3N4CA 4P6EA 4D8BA 1VJVA 4R3DA 1ITOA 3BC3A 3MORA 4WURA 2VHFA 2B1NA 2G7YA 2WBFX 2R6NA 2AUXA 3BPFA 9PAPA 1PCIA 2NQIA 1XKGA 3S3QA 3OF9A 4CDCB 4CDDB 2NQGA 3IEJA 5CVOB 2G8EA 4W4UA 4RNAA 2P86A 2G6DA 1EWLA 4BS6A 2AYNA 1X9YA 1MHWA 3WXGA 1SNKA 3KFQA 1PXVA 2OP3A 5EF4A 2NQDB 1AYUA 2GFOA 4DMXA 3CH2X 3RVXA 2BDZA 2DC8A 4MM3B 3V6CA 1BGOA 2DCDA 3U8EA 3E9SA 4W5CA 3KSEA 4D8IA 5F02A 3K24A 4FIPA 2R9NA 1S4VA 1ME4A 4P16A 1ZIVA 2YJ8A 1PADA 3S3RA 1O0EA 4YYUA 1EWOA 2P7UA 1M6DA 3QT4A 4I07A 3HD3A 2XU3A 4N4ZA 2OULA 4YV8A 2R9FA 4FK5A 1AYVA 3N3KA 4QRGA 3P5WA 2P0RA 3P5VA 4Q8HA 3BB7A 4RF0A 7PCKA 2R9CA 2DC9A 2JTCA 5CHTA 1MEGA 1AU2A 4I04A 3BWKA 1CQDA 2PNSA 5CVMA 1DF0A 1GMYA 4MI7A 3MTVA 5CHVA 2F7DA 4RF1A 3BPMA 4BOUA 2FRQA 1F2BA 1PE6A 2F1GA 1STFE 3BOWA 1Y4HA 1AU4A 2DCCA 3F75A 1CJLA 4XR7A 1POPA 5KO3A 1GLOA 2HXZA 1MS6A 2HHNA 5EZSA 2FTDA 1U9QX 3PBHA 3NHEA 2R9MA 4X6HA 2FQ9A 3PW3A 1MDWA 3H8CA 1Y08A 3K8UA 3O0UA 2YJ9A 2CB5A 3RVWA 1EF7A 4YYWA 2DJFB 2VHSA 4HXDB 2H7JA 3PRMA 5JH3A 2XU1A 1CTEA 2PREA 4CDFB 4CDEB 2J7QC 3TRKA 2DC6A 1KHQA 4MZOA 1IWDA 1KFUL 1HUCB 2Y6EA 2NQAA 4REZA 1JQPA 4AXMA 3MTNA 3BCNA 1YK8A 3CBKA 2HH5A 3MP2A 1MEMA 3GCBA 3LXSA 3QSDA 2BDLA 4OEMA 1NLJA 3HHIA 1YVBA 3HWNA 2ATOA 3BY4A 4XZXA 2R9OA 1AECA 1K3BB 1NQCA 2JRIA 4D8EA 1YT7A 3E1ZB 8PCHA 3RNVA 3PT2A 2FT2A 2BU3A 3OQCA 1YALA 4YVAA 1PVJA 3H89A 1UKFA 3KX1A 1F2AA 3IMAA 1ICFA 5EZQA 4I05A 1PPNA 3DF0A 2OZ2A 3H8BA 4G54A 2B1MA 2E00A 2AU1A 1AIMA 2CIOA 2YJBA 5PADA 1PBHA 1THEA 1AYWA 1Q6KA 2DJGB 1CB5A 4QBBA 3N3GA 1QDQA 2JQGR 1BP4A 1KXRA 4P6GA 3IHPA 3IV2A 4M0WA 4CZWA 1PPPA 1QXPA 3I3TA 2AIMA 2E01A 4X6JA 4XUIA 1NL6A 2BTWA 4RY2A 3D6SA 1U5IA 5FPWA 1BY8A 1NB5A 4HWYA 3IUTA 3F5VA 1QMYA 3HHAA 4IUMA 3KWZA 5JZEA 3M99A 4K7CA 3C0RA 3MHHA 4MZSA 1BQIA 1QOLA 1CSBB 2AS8A 2GHUA 3B21A 3WXFA 4BSQA 1CS8A 2XU5A 3MHSA 4PP1A 1ZCMA 1SP4B 3P5XA 4MSXA 3QJ3A 1VSNA 4QRVA 2JQFR 3KKUA 3TMPA 4BOZA 4OVZA 2Y5BA 3O1GA 3V6EA 3KW9A 2AVWA 2DCBA 5CVNB 3ZNHA 1YK7A 1CPJA 1CV8A 2FE8A 4YYSA 2PBHA 2ACTA 2FYEA 2HD5A 3C9EA 4AXLA 4ZUXU 1NPZA 3ERVA 4PP2E 3W31A 1U9XA 2G8JA 1PPOA 3WXEA 2XU4A 4IP3A 3AI8A 2E02A 1DKIA 1U9VA 4QH6A 1F2CA 4PI3A 2Z84A 3PDFA 2AGAA 3KWBX 3W30A 3ZUAA 1YZBA 2IBIA
chains in the Genus database with same CATH topology
4PT5A 4OVZB 3PHWA 4BOSA 4D8BA 4R3DA 4GUAA 4WURA 3PHXA 3PHUA 4M0WA 5KO3A 5EZSA 4BOQA 3PSEA 2BTWA 4ZTBA 2DOSA 4RNAA 2J7QA 4HXDB 3PRMA 4IUMA 5JZEA 2J7QC 3TRKA 3C0RA 3IFUA 4REZA 3B21A 3MP2A 4MM3B 5E6JA 3E9SA 4D8IA 3TMPA 3BY4A 4XZXA 3PRPA 2BTWB 4OVZA 4BOZA 4RKXA 4A5UA 3O65A 3ZNHA 4P16A 2JRIA 4D8EA 2FE8A 3RNVA 3PT2A 3OQCA 2BU3A 3BBAA 3MJ5A 3W31A 4BOPA 1PVJA 1UKFA 3BB7A 4RF0A 2JTCA 4OW0A 4IP3A 5EZQA 1DKIA 4MI7A 2UZJA 3MTVA 2Z84A 2AGAA 4RF1A 3W30A 2HWKA 1YZBA 4BOUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DKI A;  2UZJ A;  4D8E A;  3BB7 A;  3BBA A;  2JTC A;  4RKX A;  1PVJ A;  4D8I A;  4D8B A; 
#chains in the Genus database with same CATH topology
 1AU0 A;  3PHW A;  1GCB A;  4BOS A;  1F29 A;  1CVZ A;  2FRA A;  3B79 A;  4GUA A;  3P5U A;  2FUD A;  3PHX A;  3H6S A;  3PHU A;  1KHP A;  2YJ2 A;  1TU6 A;  1PPD A;  2O6X A;  4BOQ A;  3PSE A;  4ZTB A;  3RVV A;  1TLO A;  1ME3 A;  2DZY A;  1MIR A;  4YYQ A;  2DOS A;  5JA7 A;  4BS5 A;  2J7Q A;  1GEC E;  3OIS A;  3OVX A;  6PAD A;  4Q8G A;  1A6R A;  1DEU A;  2ARY A;  3IFU A;  3LFY A;  4KLB A;  2IPP B;  4PAD A;  1PIP A;  3I06 A;  2DC7 A;  3USV A;  4YYR A;  1TL9 A;  4OEL A;  4BPV A;  1EWP A;  1ATK A;  2C0Y A;  5E6J A;  3CH3 X;  3OF8 A;  4BQV A;  3PRP A;  2BTW B;  3OVZ A;  1FH0 A;  4RKX A;  4A5U A;  3O65 A;  3CBJ A;  1AU3 A;  5J94 A;  4W5B A;  3BBA A;  4N8W A;  3MJ5 A;  4BOP A;  4DMY A;  3IOQ A;  4YYV A;  3H7D A;  1EWM A;  4OW0 A;  5EGW A;  1U9W A;  4QRX A;  4FJC A;  1NB3 A;  4WA6 A;  2UZJ A;  2YJC A;  5A24 A;  4X6I A;  2DZZ A;  2DCA A;  2PAD A;  2HWK A;  3TNX A;  4PT5 A;  2E03 A;  4N79 A;  4OVZ B;  2FO5 A;  5K16 A;  3PNR A;  2AYO A;  2AUZ A;  1KFX L;  3K9M A;  3N4C A;  4P6E A;  4D8B A;  1VJV A;  4R3D A;  1ITO A;  3BC3 A;  3MOR A;  4WUR A;  2VHF A;  2B1N A;  2G7Y A;  2WBF X;  2R6N A;  2AUX A;  3BPF A;  9PAP A;  1PCI A;  2NQI A;  1XKG A;  3S3Q A;  3OF9 A;  4CDC B;  4CDD B;  2NQG A;  3IEJ A;  5CVO B;  2G8E A;  4W4U A;  4RNA A;  2P86 A;  2G6D A;  1EWL A;  4BS6 A;  2AYN A;  1X9Y A;  1MHW A;  3WXG A;  1SNK A;  3KFQ A;  1PXV A;  2OP3 A;  5EF4 A;  2NQD B;  1AYU A;  2GFO A;  4DMX A;  3CH2 X;  3RVX A;  2BDZ A;  2DC8 A;  4MM3 B;  3V6C A;  1BGO A;  2DCD A;  3U8E A;  3E9S A;  4W5C A;  3KSE A;  4D8I A;  5F02 A;  3K24 A;  4FIP A;  2R9N A;  1S4V A;  1ME4 A;  4P16 A;  1ZIV A;  2YJ8 A;  1PAD A;  3S3R A;  1O0E A;  4YYU A;  1EWO A;  2P7U A;  1M6D A;  3QT4 A;  4I07 A;  3HD3 A;  2XU3 A;  4N4Z A;  2OUL A;  4YV8 A;  2R9F A;  4FK5 A;  1AYV A;  3N3K A;  4QRG A;  3P5W A;  2P0R A;  3P5V A;  4Q8H A;  3BB7 A;  4RF0 A;  7PCK A;  2R9C A;  2DC9 A;  2JTC A;  5CHT A;  1MEG A;  1AU2 A;  4I04 A;  3BWK A;  1CQD A;  2PNS A;  5CVM A;  1DF0 A;  1GMY A;  4MI7 A;  3MTV A;  5CHV A;  2F7D A;  4RF1 A;  3BPM A;  4BOU A;  2FRQ A;  1F2B A;  1PE6 A;  2F1G A;  1STF E;  3BOW A;  1Y4H A;  1AU4 A;  2DCC A;  3F75 A;  1CJL A;  4XR7 A;  1POP A;  5KO3 A;  1GLO A;  2HXZ A;  1MS6 A;  2HHN A;  5EZS A;  2FTD A;  1U9Q X;  3PBH A;  3NHE A;  2R9M A;  4X6H A;  2FQ9 A;  3PW3 A;  1MDW A;  3H8C A;  1Y08 A;  3K8U A;  3O0U A;  2YJ9 A;  2CB5 A;  3RVW A;  1EF7 A;  4YYW A;  2DJF B;  2VHS A;  4HXD B;  2H7J A;  3PRM A;  5JH3 A;  2XU1 A;  1CTE A;  2PRE A;  4CDF B;  4CDE B;  2J7Q C;  3TRK A;  2DC6 A;  1KHQ A;  4MZO A;  1IWD A;  1KFU L;  1HUC B;  2Y6E A;  2NQA A;  4REZ A;  1JQP A;  4AXM A;  3MTN A;  3BCN A;  1YK8 A;  3CBK A;  2HH5 A;  3MP2 A;  1MEM A;  3GCB A;  3LXS A;  3QSD A;  2BDL A;  4OEM A;  1NLJ A;  3HHI A;  1YVB A;  3HWN A;  2ATO A;  3BY4 A;  4XZX A;  2R9O A;  1AEC A;  1K3B B;  1NQC A;  2JRI A;  4D8E A;  1YT7 A;  3E1Z B;  8PCH A;  3RNV A;  3PT2 A;  2FT2 A;  2BU3 A;  3OQC A;  1YAL A;  4YVA A;  1PVJ A;  3H89 A;  1UKF A;  3KX1 A;  1F2A A;  3IMA A;  1ICF A;  5EZQ A;  4I05 A;  1PPN A;  3DF0 A;  2OZ2 A;  3H8B A;  4G54 A;  2B1M A;  2E00 A;  2AU1 A;  1AIM A;  2CIO A;  2YJB A;  5PAD A;  1PBH A;  1THE A;  1AYW A;  1Q6K A;  2DJG B;  1CB5 A;  4QBB A;  3N3G A;  1QDQ A;  2JQG R;  1BP4 A;  1KXR A;  4P6G A;  3IHP A;  3IV2 A;  4M0W A;  4CZW A;  1PPP A;  1QXP A;  3I3T A;  2AIM A;  2E01 A;  4X6J A;  4XUI A;  1NL6 A;  2BTW A;  4RY2 A;  3D6S A;  1U5I A;  5FPW A;  1BY8 A;  1NB5 A;  4HWY A;  3IUT A;  3F5V A;  1QMY A;  3HHA A;  4IUM A;  3KWZ A;  5JZE A;  3M99 A;  4K7C A;  3C0R A;  3MHH A;  4MZS A;  1BQI A;  1QOL A;  1CSB B;  2AS8 A;  2GHU A;  3B21 A;  3WXF A;  4BSQ A;  1CS8 A;  2XU5 A;  3MHS A;  4PP1 A;  1ZCM A;  1SP4 B;  3P5X A;  4MSX A;  3QJ3 A;  1VSN A;  4QRV A;  2JQF R;  3KKU A;  3TMP A;  4BOZ A;  4OVZ A;  2Y5B A;  3O1G A;  3V6E A;  3KW9 A;  2AVW A;  2DCB A;  5CVN B;  3ZNH A;  1YK7 A;  1CPJ A;  1CV8 A;  2FE8 A;  4YYS A;  2PBH A;  2ACT A;  2FYE A;  2HD5 A;  3C9E A;  4AXL A;  4ZUX U;  1NPZ A;  3ERV A;  4PP2 E;  3W31 A;  1U9X A;  2G8J A;  1PPO A;  3WXE A;  2XU4 A;  4IP3 A;  3AI8 A;  2E02 A;  1DKI A;  1U9V A;  4QH6 A;  1F2C A;  4PI3 A;  2Z84 A;  3PDF A;  2AGA A;  3KWB X;  3W30 A;  3ZUA A;  1YZB A;  2IBI A; 
#chains in the Genus database with same CATH homology
 4PT5 A;  4OVZ B;  3PHW A;  4BOS A;  4D8B A;  4R3D A;  4GUA A;  4WUR A;  3PHX A;  3PHU A;  4M0W A;  5KO3 A;  5EZS A;  4BOQ A;  3PSE A;  2BTW A;  4ZTB A;  2DOS A;  4RNA A;  2J7Q A;  4HXD B;  3PRM A;  4IUM A;  5JZE A;  2J7Q C;  3TRK A;  3C0R A;  3IFU A;  4REZ A;  3B21 A;  3MP2 A;  4MM3 B;  5E6J A;  3E9S A;  4D8I A;  3TMP A;  3BY4 A;  4XZX A;  3PRP A;  2BTW B;  4OVZ A;  4BOZ A;  4RKX A;  4A5U A;  3O65 A;  3ZNH A;  4P16 A;  2JRI A;  4D8E A;  2FE8 A;  3RNV A;  3PT2 A;  3OQC A;  2BU3 A;  3BBA A;  3MJ5 A;  3W31 A;  4BOP A;  1PVJ A;  1UKF A;  3BB7 A;  4RF0 A;  2JTC A;  4OW0 A;  4IP3 A;  5EZQ A;  1DKI A;  4MI7 A;  2UZJ A;  3MTV A;  2Z84 A;  2AGA A;  4RF1 A;  3W30 A;  2HWK A;  1YZB A;  4BOU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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