4X6JA

Development of n-(functionalized benzoyl)-homocycloleucyl-glycinonitriles as potent cathepsin k inhibitors.
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
215
structure length
215
Chain Sequence
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Cathepsin K
total genus 65
structure length 215
sequence length 215
ec nomenclature ec 3.4.22.38: Cathepsin K.
pdb deposition date 2014-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4x6jA00
2NQAA 3MHHA 2HD5A 2WBFX 1PCIA 3M99A 1A6RA 1FH0A 1M6DA 3U8EA 2FRAA 5CVOB 4DMXA 4HWYA 1GCBA 2AVWA 3HHIA 2R9NA 2R9MA 5K16A 4G54A 1AYUA 1PPOA 3I06A 4Q8GA 4X6HA 1BGOA 2DCAA 4YVAA 4KLBA 2AU1A 3B79A 2YJ9A 2FO5A 2F7DA 1CJLA 1QDQA 3S3RA 1O0EA 4MSXA 1BQIA 2AYOA 3P5VA 2E03A 4FJCA 4DMYA 1JQPA 1PPPA 3WXGA 5A24A 2H7JA 1U5IA 3PBHA 2G7YA 2P0RA 4OEMA 5CVNB 4OELA 1CS8A 2DZYA 3KFQA 4AXMA 4CDCB 4P6GA 1ATKA 4CDFB 1AU4A 3PNRA 2G8EA 2IBIA 3H8CA 3KKUA 3CBJA 2P86A 3HWNA 4RY2A 2YJ2A 2P7UA 4WA6A 3KSEA 3PW3A 2VHFA 1ITOA 2DJFB 1EWMA 2FUDA 3BOWA 3WXEA 3E1ZB 1PPDA 6PADA 1XKGA 4BS5A 3BWKA 1GMYA 1PADA 3KWBX 2HH5A 4MZOA 1YK8A 3BCNA 3QSDA 3H7DA 4QBBA 4YYSA 1Y08A 2DZZA 4CDDB 1PE6A 1GLOA 2PADA 1NPZA 2Y6EA 3BC3A 1PIPA 3O0UA 4PADA 1ZCMA 2C0YA 1AECA 2XU1A 2NQGA 3GCBA 1TU6A 4XR7A 3LFYA 2DC9A 2DC6A 1EWLA 5CHTA 5JH3A 2XU5A 3BPFA 3AI8A 3IUTA 5J94A 4AXLA 2YJ8A 3CH3X 1KFUL 1F29A 3N4CA 3S3QA 1NB3A 1POPA 1TLOA 1KHQA 4PP1A 9PAPA 1CSBB 1KFXL 4N4ZA 4W5BA 1F2CA 1STFE 4CDEB 4I04A 4QRGA 1EF7A 4PI3A 2OP3A 4YV8A 2DCDA 2CB5A 2G8JA 3IEJA 1F2BA 3V6CA 4W5CA 3OVXA 4YYQA 2YJBA 3KW9A 1YALA 3RVXA 5JA7A 4PP2E 2F1GA 2OZ2A 3D6SA 4Q8HA 1SNKA 2FYEA 4BPVA 3IHPA 1U9VA 3V6EA 3K24A 7PCKA 1Q6KA 2JQFR 3H6SA 3OISA 1MIRA 1ME4A 2FT2A 1YT7A 2R9CA 1AU3A 2DCCA 1IWDA 3BPMA 4YYUA 2CIOA 2DC7A 2GFOA 1GECE 2E01A 5CVMA 2E02A 2GHUA 2PREA 1ICFA 1CQDA 1S4VA 2NQIA 2AS8A 2FTDA 4X6IA 2VHSA 3HD3A 3H8BA 1BP4A 4W4UA 3PDFA 1YVBA 4N8WA 1U9QX 1K3BB 3OF9A 2XU4A 3H89A 2G6DA 1VJVA 2AUXA 2DCBA 2B1NA 2ARYA 1KXRA 1MS6A 3RVVA 3K8UA 2E00A 4ZUXU 3IMAA 1AU2A 3P5WA 1NB5A 5EGWA 1MHWA 1NL6A 2PBHA 4YYWA 1CVZA 4YYRA 3OF8A 4MZSA 4BS6A 4K7CA 1PPNA 1KHPA 1SP4B 1CPJA 5CHVA 3USVA 4BSQA 1MEGA 1VSNA 3IOQA 3P5XA 1EWOA 4P6EA 3RVWA 2DJGB 3QJ3A 2BDZA 3MORA 2Y5BA 3O1GA 1BY8A 4FK5A 3HHAA 1X9YA 2IPPB 3CBKA 2ACTA 1YK7A 3F75A 2NQDB 2FRQA 2R9FA 5PADA 4N79A 1MDWA 3MHSA 4X6JA 1EWPA 4CZWA 1AYVA 2HHNA 3ERVA 4I07A 1DEUA 3MTNA 1CTEA 2R9OA 4BQVA 2AIMA 1TL9A 1U9WA 3KWZA 1Y4HA 3DF0A 1AYWA 3IV2A 3CH2X 1ME3A 1QOLA 1DF0A 1NQCA 1MEMA 1QXPA 1U9XA 2JQGR 3F5VA 1CB5A 3P5UA 2AUZA 2BDLA 1ZIVA 4YYVA 1AIMA 2OULA 8PCHA 2DC8A 1THEA 3QT4A 1HUCB 1F2AA 3KX1A 2PNSA 2YJCA 3TNXA 3WXFA 2HXZA 1CV8A 1PXVA 3LXSA 5F02A 4XUIA 3OVZA 1PBHA 3I3TA 1AU0A 1NLJA 3K9MA 4FIPA 3N3KA 4QRXA 3C9EA 2ATOA 4QH6A 2B1MA 2FQ9A 5FPWA 2AYNA 5EF4A 4I05A 3N3GA 2R6NA 2XU3A 3NHEA 1QMYA 3ZUAA 4QRVA 2O6XA
chains in the Genus database with same CATH superfamily
2NQAA 4MM3B 3MHHA 2HD5A 2WBFX 1PCIA 3M99A 1A6RA 1FH0A 1M6DA 3U8EA 2FRAA 3MJ5A 5CVOB 4DMXA 4HWYA 1GCBA 2AVWA 3HHIA 2R9NA 2R9MA 5K16A 4G54A 1AYUA 2JRIA 1PPOA 3I06A 4Q8GA 4X6HA 1BGOA 2DCAA 4YVAA 2FE8A 4KLBA 2AU1A 3B79A 2YJ9A 2FO5A 2F7DA 1CJLA 1QDQA 3O65A 3S3RA 1O0EA 4MSXA 1BQIA 2DOSA 2BTWA 2AYOA 3P5VA 2E03A 4FJCA 4DMYA 1JQPA 1PPPA 3WXGA 3PT2A 5A24A 2H7JA 1U5IA 3PBHA 2G7YA 2P0RA 4OEMA 3BB7A 5CVNB 4OELA 1CS8A 2DZYA 3KFQA 4AXMA 4CDCB 4P6GA 1ATKA 4CDFB 1AU4A 3PNRA 2G8EA 2IBIA 3H8CA 3KKUA 3CBJA 4REZA 2P86A 1PVJA 3HWNA 4RY2A 2YJ2A 2P7UA 4WA6A 4XZXA 3KSEA 3PW3A 2VHFA 1ITOA 5E6JA 2DJFB 1EWMA 2FUDA 3BOWA 3WXEA 4BOZA 3E1ZB 1PPDA 6PADA 1XKGA 4BS5A 1YZBA 3BWKA 1GMYA 1PADA 3KWBX 3OQCA 2HH5A 4MZOA 1YK8A 4M0WA 4OW0A 3BCNA 3QSDA 3H7DA 4QBBA 3TRKA 4YYSA 1Y08A 2DZZA 4CDDB 1PE6A 3PRMA 1GLOA 2PADA 1NPZA 4R3DA 2Y6EA 3BC3A 1PIPA 3O0UA 4PADA 1ZCMA 3TMPA 2C0YA 1AECA 2XU1A 2NQGA 5EZSA 3GCBA 1TU6A 3E9SA 4XR7A 3PHUA 4IUMA 3LFYA 2DC9A 2DC6A 1EWLA 5CHTA 5JH3A 2XU5A 3BPFA 3AI8A 3IUTA 5J94A 4AXLA 2YJ8A 3CH3X 1KFUL 1F29A 3N4CA 3S3QA 1NB3A 2HWKA 1POPA 3MP2A 1TLOA 1KHQA 4PP1A 9PAPA 1CSBB 1KFXL 4N4ZA 4W5BA 3IFUA 1F2CA 1STFE 4CDEB 3BY4A 4I04A 4QRGA 1EF7A 4PI3A 2OP3A 4BOQA 4YV8A 2DCDA 2CB5A 2G8JA 3IEJA 5KO3A 1F2BA 3V6CA 4W5CA 3OVXA 4YYQA 2YJBA 3KW9A 1YALA 4RNAA 3RVXA 5JA7A 5EZQA 4PP2E 2F1GA 2OZ2A 3D6SA 4Q8HA 1SNKA 2FYEA 4BPVA 3IHPA 1U9VA 3V6EA 3K24A 1UKFA 3PHWA 7PCKA 1Q6KA 2JQFR 3H6SA 3OISA 1MIRA 1ME4A 2FT2A 1YT7A 3PRPA 2R9CA 1AU3A 2DCCA 1IWDA 3BPMA 4YYUA 2CIOA 2DC7A 2GFOA 1GECE 3PSEA 3W31A 2E01A 5CVMA 2E02A 2GHUA 2PREA 1ICFA 1CQDA 1S4VA 2NQIA 2AS8A 2FTDA 4X6IA 2VHSA 3HD3A 3H8BA 1BP4A 4W4UA 3PDFA 1YVBA 4N8WA 4RKXA 1U9QX 4ZTBA 1K3BB 3OF9A 2XU4A 3H89A 2G6DA 1VJVA 2AUXA 2Z84A 5JZEA 2AGAA 2DCBA 2B1NA 2ARYA 1KXRA 1MS6A 3RVVA 3K8UA 4OVZA 2E00A 4ZUXU 3IMAA 1AU2A 3P5WA 2UZJA 1NB5A 5EGWA 4RF1A 1MHWA 1NL6A 2PBHA 4YYWA 1CVZA 4YYRA 3OF8A 4HXDB 4MZSA 3BBAA 4BS6A 4K7CA 1PPNA 1KHPA 3W30A 1SP4B 1CPJA 5CHVA 3USVA 3B21A 1MEGA 4GUAA 4WURA 4BSQA 1VSNA 3IOQA 3P5XA 4RF0A 1EWOA 4P6EA 3RVWA 2DJGB 3QJ3A 2BDZA 3MORA 2Y5BA 3O1GA 4MI7A 1BY8A 4BOPA 4FK5A 4A5UA 3HHAA 4D8BA 1X9YA 2IPPB 3CBKA 4BOSA 2ACTA 1YK7A 3F75A 2NQDB 2BU3A 2FRQA 2R9FA 5PADA 4N79A 1MDWA 3MHSA 4X6JA 1EWPA 4CZWA 1AYVA 2HHNA 3ERVA 4I07A 1DEUA 3MTNA 1CTEA 2R9OA 4OVZB 4BQVA 3PHXA 2AIMA 1TL9A 1U9WA 3KWZA 1Y4HA 3DF0A 1AYWA 3IV2A 3CH2X 1ME3A 1QOLA 1DF0A 1NQCA 3ZNHA 1MEMA 1DKIA 1QXPA 3C0RA 1U9XA 2JQGR 3F5VA 1CB5A 3P5UA 4D8IA 2AUZA 2BDLA 4IP3A 4PT5A 1ZIVA 2JTCA 4YYVA 1AIMA 2OULA 8PCHA 2DC8A 1THEA 3QT4A 1HUCB 1F2AA 2J7QA 3KX1A 2PNSA 2YJCA 3TNXA 3WXFA 2HXZA 1CV8A 1PXVA 3LXSA 5F02A 4XUIA 3OVZA 1PBHA 3I3TA 1AU0A 1NLJA 4BOUA 3K9MA 4FIPA 3N3KA 2BTWB 4P16A 4QRXA 3C9EA 3RNVA 2ATOA 4QH6A 2B1MA 2FQ9A 2J7QC 5FPWA 2AYNA 5EF4A 4I05A 4D8EA 3N3GA 2R6NA 2XU3A 3NHEA 1QMYA 3MTVA 3ZUAA 4QRVA 2O6XA
chains in the Genus database with same CATH topology
2NQAA 3MHHA 2HD5A 2WBFX 1PCIA 3M99A 1A6RA 1FH0A 1M6DA 3U8EA 2FRAA 5CVOB 4DMXA 4HWYA 1GCBA 2AVWA 3HHIA 2R9NA 2R9MA 5K16A 4G54A 1AYUA 1PPOA 3I06A 4Q8GA 4X6HA 1BGOA 2DCAA 4YVAA 4KLBA 2AU1A 3B79A 2YJ9A 2FO5A 2F7DA 1CJLA 1QDQA 3S3RA 1O0EA 4MSXA 1BQIA 2AYOA 3P5VA 2E03A 4FJCA 4DMYA 1JQPA 1PPPA 3WXGA 5A24A 2H7JA 1U5IA 3PBHA 2G7YA 2P0RA 4OEMA 5CVNB 4OELA 1CS8A 2DZYA 3KFQA 4AXMA 4CDCB 4P6GA 1ATKA 4CDFB 1AU4A 3PNRA 2G8EA 2IBIA 3H8CA 3KKUA 3CBJA 2P86A 3HWNA 4RY2A 2YJ2A 2P7UA 4WA6A 3KSEA 3PW3A 2VHFA 1ITOA 2DJFB 1EWMA 2FUDA 3BOWA 3WXEA 3E1ZB 1PPDA 6PADA 1XKGA 4BS5A 3BWKA 1GMYA 1PADA 3KWBX 2HH5A 4MZOA 1YK8A 3BCNA 3QSDA 3H7DA 4QBBA 4YYSA 1Y08A 2DZZA 4CDDB 1PE6A 3D9WA 1GLOA 2PADA 1NPZA 2Y6EA 3BC3A 1PIPA 3O0UA 4PADA 1ZCMA 2C0YA 1AECA 2XU1A 2NQGA 3GCBA 1TU6A 4XR7A 3LFYA 2DC9A 2DC6A 1EWLA 5CHTA 5JH3A 2XU5A 3BPFA 3AI8A 3IUTA 5J94A 4AXLA 2YJ8A 3CH3X 1KFUL 1F29A 3N4CA 3S3QA 1NB3A 2VFCA 1POPA 1TLOA 1KHQA 4PP1A 9PAPA 1CSBB 1KFXL 4N4ZA 4W5BA 1F2CA 1STFE 4CDEB 4I04A 4QRGA 1EF7A 4PI3A 2OP3A 4GUZA 4YV8A 2DCDA 1W6FA 2CB5A 2G8JA 3IEJA 1F2BA 3V6CA 4W5CA 3OVXA 4YYQA 2YJBA 3KW9A 1YALA 3RVXA 5JA7A 4PP2E 2F1GA 2OZ2A 3D6SA 4Q8HA 1SNKA 2FYEA 4BPVA 3IHPA 1U9VA 3V6EA 3K24A 7PCKA 1Q6KA 2JQFR 3H6SA 3OISA 1MIRA 1ME4A 2FT2A 1YT7A 4B55A 2R9CA 1AU3A 2DCCA 1IWDA 3BPMA 4YYUA 2CIOA 2DC7A 2GFOA 1GECE 2E01A 5CVMA 2E02A 2GHUA 2PREA 1W4TA 1ICFA 1CQDA 1S4VA 2NQIA 2AS8A 2FTDA 4X6IA 2VHSA 3HD3A 3H8BA 1BP4A 4W4UA 3PDFA 1YVBA 4N8WA 1U9QX 1K3BB 3OF9A 2XU4A 3H89A 4BGFA 2G6DA 1VJVA 2AUXA 3LTWA 2DCBA 2B1NA 2ARYA 1KXRA 1MS6A 3RVVA 3K8UA 2E00A 4ZUXU 3IMAA 1AU2A 1GX3A 3P5WA 1NB5A 5EGWA 1MHWA 1NL6A 2PBHA 4YYWA 1CVZA 4YYRA 3OF8A 4MZSA 4BS6A 4K7CA 1PPNA 1KHPA 1SP4B 1CPJA 5CHVA 3USVA 4BSQA 1MEGA 1VSNA 3IOQA 3P5XA 1EWOA 4P6EA 3RVWA 2DJGB 3QJ3A 2BDZA 3MORA 2Y5BA 3O1GA 1BY8A 4FK5A 3HHAA 1X9YA 2IPPB 3CBKA 2ACTA 1YK7A 3F75A 2NQDB 2BSZA 2FRQA 2R9FA 5PADA 4N79A 1MDWA 3MHSA 4X6JA 1EWPA 4CZWA 1AYVA 2HHNA 3ERVA 4I07A 1DEUA 3MTNA 1CTEA 2R9OA 4BQVA 2AIMA 1TL9A 1U9WA 3KWZA 1Y4HA 3DF0A 1AYWA 3IV2A 3CH2X 1ME3A 1QOLA 1DF0A 1NQCA 1MEMA 1QXPA 1U9XA 2JQGR 3F5VA 4NV7A 1CB5A 3P5UA 4C5PA 2AUZA 2BDLA 1W5RA 1ZIVA 4YYVA 1E2TA 1AIMA 2OULA 8PCHA 2DC8A 1THEA 3QT4A 1HUCB 1F2AA 3KX1A 2PNSA 2YJCA 3TNXA 3WXFA 2HXZA 1CV8A 1PXVA 3LXSA 5F02A 4XUIA 3OVZA 1PBHA 3I3TA 1AU0A 1NLJA 3K9MA 4FIPA 3N3KA 4QRXA 3C9EA 2ATOA 4QH6A 2B1MA 2FQ9A 5FPWA 2AYNA 5EF4A 4I05A 3N3GA 2R6NA 2XU3A 3NHEA 1QMYA 3ZUAA 4QRVA 2VFBA 4NV8A 2O6XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NQA A;  3MHH A;  2HD5 A;  2WBF X;  1PCI A;  3M99 A;  1A6R A;  1FH0 A;  1M6D A;  3U8E A;  2FRA A;  5CVO B;  4DMX A;  4HWY A;  1GCB A;  2AVW A;  3HHI A;  2R9N A;  2R9M A;  5K16 A;  4G54 A;  1AYU A;  1PPO A;  3I06 A;  4Q8G A;  4X6H A;  1BGO A;  2DCA A;  4YVA A;  4KLB A;  2AU1 A;  3B79 A;  2YJ9 A;  2FO5 A;  2F7D A;  1CJL A;  1QDQ A;  3S3R A;  1O0E A;  4MSX A;  1BQI A;  2AYO A;  3P5V A;  2E03 A;  4FJC A;  4DMY A;  1JQP A;  1PPP A;  3WXG A;  5A24 A;  2H7J A;  1U5I A;  3PBH A;  2G7Y A;  2P0R A;  4OEM A;  5CVN B;  4OEL A;  1CS8 A;  2DZY A;  3KFQ A;  4AXM A;  4CDC B;  4P6G A;  1ATK A;  4CDF B;  1AU4 A;  3PNR A;  2G8E A;  2IBI A;  3H8C A;  3KKU A;  3CBJ A;  2P86 A;  3HWN A;  4RY2 A;  2YJ2 A;  2P7U A;  4WA6 A;  3KSE A;  3PW3 A;  2VHF A;  1ITO A;  2DJF B;  1EWM A;  2FUD A;  3BOW A;  3WXE A;  3E1Z B;  1PPD A;  6PAD A;  1XKG A;  4BS5 A;  3BWK A;  1GMY A;  1PAD A;  3KWB X;  2HH5 A;  4MZO A;  1YK8 A;  3BCN A;  3QSD A;  3H7D A;  4QBB A;  4YYS A;  1Y08 A;  2DZZ A;  4CDD B;  1PE6 A;  1GLO A;  2PAD A;  1NPZ A;  2Y6E A;  3BC3 A;  1PIP A;  3O0U A;  4PAD A;  1ZCM A;  2C0Y A;  1AEC A;  2XU1 A;  2NQG A;  3GCB A;  1TU6 A;  4XR7 A;  3LFY A;  2DC9 A;  2DC6 A;  1EWL A;  5CHT A;  5JH3 A;  2XU5 A;  3BPF A;  3AI8 A;  3IUT A;  5J94 A;  4AXL A;  2YJ8 A;  3CH3 X;  1KFU L;  1F29 A;  3N4C A;  3S3Q A;  1NB3 A;  1POP A;  1TLO A;  1KHQ A;  4PP1 A;  9PAP A;  1CSB B;  1KFX L;  4N4Z A;  4W5B A;  1F2C A;  1STF E;  4CDE B;  4I04 A;  4QRG A;  1EF7 A;  4PI3 A;  2OP3 A;  4YV8 A;  2DCD A;  2CB5 A;  2G8J A;  3IEJ A;  1F2B A;  3V6C A;  4W5C A;  3OVX A;  4YYQ A;  2YJB A;  3KW9 A;  1YAL A;  3RVX A;  5JA7 A;  4PP2 E;  2F1G A;  2OZ2 A;  3D6S A;  4Q8H A;  1SNK A;  2FYE A;  4BPV A;  3IHP A;  1U9V A;  3V6E A;  3K24 A;  7PCK A;  1Q6K A;  2JQF R;  3H6S A;  3OIS A;  1MIR A;  1ME4 A;  2FT2 A;  1YT7 A;  2R9C A;  1AU3 A;  2DCC A;  1IWD A;  3BPM A;  4YYU A;  2CIO A;  2DC7 A;  2GFO A;  1GEC E;  2E01 A;  5CVM A;  2E02 A;  2GHU A;  2PRE A;  1ICF A;  1CQD A;  1S4V A;  2NQI A;  2AS8 A;  2FTD A;  4X6I A;  2VHS A;  3HD3 A;  3H8B A;  1BP4 A;  4W4U A;  3PDF A;  1YVB A;  4N8W A;  1U9Q X;  1K3B B;  3OF9 A;  2XU4 A;  3H89 A;  2G6D A;  1VJV A;  2AUX A;  2DCB A;  2B1N A;  2ARY A;  1KXR A;  1MS6 A;  3RVV A;  3K8U A;  2E00 A;  4ZUX U;  3IMA A;  1AU2 A;  3P5W A;  1NB5 A;  5EGW A;  1MHW A;  1NL6 A;  2PBH A;  4YYW A;  1CVZ A;  4YYR A;  3OF8 A;  4MZS A;  4BS6 A;  4K7C A;  1PPN A;  1KHP A;  1SP4 B;  1CPJ A;  5CHV A;  3USV A;  4BSQ A;  1MEG A;  1VSN A;  3IOQ A;  3P5X A;  1EWO A;  4P6E A;  3RVW A;  2DJG B;  3QJ3 A;  2BDZ A;  3MOR A;  2Y5B A;  3O1G A;  1BY8 A;  4FK5 A;  3HHA A;  1X9Y A;  2IPP B;  3CBK A;  2ACT A;  1YK7 A;  3F75 A;  2NQD B;  2FRQ A;  2R9F A;  5PAD A;  4N79 A;  1MDW A;  3MHS A;  4X6J A;  1EWP A;  4CZW A;  1AYV A;  2HHN A;  3ERV A;  4I07 A;  1DEU A;  3MTN A;  1CTE A;  2R9O A;  4BQV A;  2AIM A;  1TL9 A;  1U9W A;  3KWZ A;  1Y4H A;  3DF0 A;  1AYW A;  3IV2 A;  3CH2 X;  1ME3 A;  1QOL A;  1DF0 A;  1NQC A;  1MEM A;  1QXP A;  1U9X A;  2JQG R;  3F5V A;  1CB5 A;  3P5U A;  2AUZ A;  2BDL A;  1ZIV A;  4YYV A;  1AIM A;  2OUL A;  8PCH A;  2DC8 A;  1THE A;  3QT4 A;  1HUC B;  1F2A A;  3KX1 A;  2PNS A;  2YJC A;  3TNX A;  3WXF A;  2HXZ A;  1CV8 A;  1PXV A;  3LXS A;  5F02 A;  4XUI A;  3OVZ A;  1PBH A;  3I3T A;  1AU0 A;  1NLJ A;  3K9M A;  4FIP A;  3N3K A;  4QRX A;  3C9E A;  2ATO A;  4QH6 A;  2B1M A;  2FQ9 A;  5FPW A;  2AYN A;  5EF4 A;  4I05 A;  3N3G A;  2R6N A;  2XU3 A;  3NHE A;  1QMY A;  3ZUA A;  4QRV A;  2O6X A; 
#chains in the Genus database with same CATH topology
 2NQA A;  4MM3 B;  3MHH A;  2HD5 A;  2WBF X;  1PCI A;  3M99 A;  1A6R A;  1FH0 A;  1M6D A;  3U8E A;  2FRA A;  3MJ5 A;  5CVO B;  4DMX A;  4HWY A;  1GCB A;  2AVW A;  3HHI A;  2R9N A;  2R9M A;  5K16 A;  4G54 A;  1AYU A;  2JRI A;  1PPO A;  3I06 A;  4Q8G A;  4X6H A;  1BGO A;  2DCA A;  4YVA A;  2FE8 A;  4KLB A;  2AU1 A;  3B79 A;  2YJ9 A;  2FO5 A;  2F7D A;  1CJL A;  1QDQ A;  3O65 A;  3S3R A;  1O0E A;  4MSX A;  1BQI A;  2DOS A;  2BTW A;  2AYO A;  3P5V A;  2E03 A;  4FJC A;  4DMY A;  1JQP A;  1PPP A;  3WXG A;  3PT2 A;  5A24 A;  2H7J A;  1U5I A;  3PBH A;  2G7Y A;  2P0R A;  4OEM A;  3BB7 A;  5CVN B;  4OEL A;  1CS8 A;  2DZY A;  3KFQ A;  4AXM A;  4CDC B;  4P6G A;  1ATK A;  4CDF B;  1AU4 A;  3PNR A;  2G8E A;  2IBI A;  3H8C A;  3KKU A;  3CBJ A;  4REZ A;  2P86 A;  1PVJ A;  3HWN A;  4RY2 A;  2YJ2 A;  2P7U A;  4WA6 A;  4XZX A;  3KSE A;  3PW3 A;  2VHF A;  1ITO A;  5E6J A;  2DJF B;  1EWM A;  2FUD A;  3BOW A;  3WXE A;  4BOZ A;  3E1Z B;  1PPD A;  6PAD A;  1XKG A;  4BS5 A;  1YZB A;  3BWK A;  1GMY A;  1PAD A;  3KWB X;  3OQC A;  2HH5 A;  4MZO A;  1YK8 A;  4M0W A;  4OW0 A;  3BCN A;  3QSD A;  3H7D A;  4QBB A;  3TRK A;  4YYS A;  1Y08 A;  2DZZ A;  4CDD B;  1PE6 A;  3PRM A;  1GLO A;  2PAD A;  1NPZ A;  4R3D A;  2Y6E A;  3BC3 A;  1PIP A;  3O0U A;  4PAD A;  1ZCM A;  3TMP A;  2C0Y A;  1AEC A;  2XU1 A;  2NQG A;  5EZS A;  3GCB A;  1TU6 A;  3E9S A;  4XR7 A;  3PHU A;  4IUM A;  3LFY A;  2DC9 A;  2DC6 A;  1EWL A;  5CHT A;  5JH3 A;  2XU5 A;  3BPF A;  3AI8 A;  3IUT A;  5J94 A;  4AXL A;  2YJ8 A;  3CH3 X;  1KFU L;  1F29 A;  3N4C A;  3S3Q A;  1NB3 A;  2HWK A;  1POP A;  3MP2 A;  1TLO A;  1KHQ A;  4PP1 A;  9PAP A;  1CSB B;  1KFX L;  4N4Z A;  4W5B A;  3IFU A;  1F2C A;  1STF E;  4CDE B;  3BY4 A;  4I04 A;  4QRG A;  1EF7 A;  4PI3 A;  2OP3 A;  4BOQ A;  4YV8 A;  2DCD A;  2CB5 A;  2G8J A;  3IEJ A;  5KO3 A;  1F2B A;  3V6C A;  4W5C A;  3OVX A;  4YYQ A;  2YJB A;  3KW9 A;  1YAL A;  4RNA A;  3RVX A;  5JA7 A;  5EZQ A;  4PP2 E;  2F1G A;  2OZ2 A;  3D6S A;  4Q8H A;  1SNK A;  2FYE A;  4BPV A;  3IHP A;  1U9V A;  3V6E A;  3K24 A;  1UKF A;  3PHW A;  7PCK A;  1Q6K A;  2JQF R;  3H6S A;  3OIS A;  1MIR A;  1ME4 A;  2FT2 A;  1YT7 A;  3PRP A;  2R9C A;  1AU3 A;  2DCC A;  1IWD A;  3BPM A;  4YYU A;  2CIO A;  2DC7 A;  2GFO A;  1GEC E;  3PSE A;  3W31 A;  2E01 A;  5CVM A;  2E02 A;  2GHU A;  2PRE A;  1ICF A;  1CQD A;  1S4V A;  2NQI A;  2AS8 A;  2FTD A;  4X6I A;  2VHS A;  3HD3 A;  3H8B A;  1BP4 A;  4W4U A;  3PDF A;  1YVB A;  4N8W A;  4RKX A;  1U9Q X;  4ZTB A;  1K3B B;  3OF9 A;  2XU4 A;  3H89 A;  2G6D A;  1VJV A;  2AUX A;  2Z84 A;  5JZE A;  2AGA A;  2DCB A;  2B1N A;  2ARY A;  1KXR A;  1MS6 A;  3RVV A;  3K8U A;  4OVZ A;  2E00 A;  4ZUX U;  3IMA A;  1AU2 A;  3P5W A;  2UZJ A;  1NB5 A;  5EGW A;  4RF1 A;  1MHW A;  1NL6 A;  2PBH A;  4YYW A;  1CVZ A;  4YYR A;  3OF8 A;  4HXD B;  4MZS A;  3BBA A;  4BS6 A;  4K7C A;  1PPN A;  1KHP A;  3W30 A;  1SP4 B;  1CPJ A;  5CHV A;  3USV A;  3B21 A;  1MEG A;  4GUA A;  4WUR A;  4BSQ A;  1VSN A;  3IOQ A;  3P5X A;  4RF0 A;  1EWO A;  4P6E A;  3RVW A;  2DJG B;  3QJ3 A;  2BDZ A;  3MOR A;  2Y5B A;  3O1G A;  4MI7 A;  1BY8 A;  4BOP A;  4FK5 A;  4A5U A;  3HHA A;  4D8B A;  1X9Y A;  2IPP B;  3CBK A;  4BOS A;  2ACT A;  1YK7 A;  3F75 A;  2NQD B;  2BU3 A;  2FRQ A;  2R9F A;  5PAD A;  4N79 A;  1MDW A;  3MHS A;  4X6J A;  1EWP A;  4CZW A;  1AYV A;  2HHN A;  3ERV A;  4I07 A;  1DEU A;  3MTN A;  1CTE A;  2R9O A;  4OVZ B;  4BQV A;  3PHX A;  2AIM A;  1TL9 A;  1U9W A;  3KWZ A;  1Y4H A;  3DF0 A;  1AYW A;  3IV2 A;  3CH2 X;  1ME3 A;  1QOL A;  1DF0 A;  1NQC A;  3ZNH A;  1MEM A;  1DKI A;  1QXP A;  3C0R A;  1U9X A;  2JQG R;  3F5V A;  1CB5 A;  3P5U A;  4D8I A;  2AUZ A;  2BDL A;  4IP3 A;  4PT5 A;  1ZIV A;  2JTC A;  4YYV A;  1AIM A;  2OUL A;  8PCH A;  2DC8 A;  1THE A;  3QT4 A;  1HUC B;  1F2A A;  2J7Q A;  3KX1 A;  2PNS A;  2YJC A;  3TNX A;  3WXF A;  2HXZ A;  1CV8 A;  1PXV A;  3LXS A;  5F02 A;  4XUI A;  3OVZ A;  1PBH A;  3I3T A;  1AU0 A;  1NLJ A;  4BOU A;  3K9M A;  4FIP A;  3N3K A;  2BTW B;  4P16 A;  4QRX A;  3C9E A;  3RNV A;  2ATO A;  4QH6 A;  2B1M A;  2FQ9 A;  2J7Q C;  5FPW A;  2AYN A;  5EF4 A;  4I05 A;  4D8E A;  3N3G A;  2R6N A;  2XU3 A;  3NHE A;  1QMY A;  3MTV A;  3ZUA A;  4QRV A;  2O6X A; 
#chains in the Genus database with same CATH homology
 2NQA A;  3MHH A;  2HD5 A;  2WBF X;  1PCI A;  3M99 A;  1A6R A;  1FH0 A;  1M6D A;  3U8E A;  2FRA A;  5CVO B;  4DMX A;  4HWY A;  1GCB A;  2AVW A;  3HHI A;  2R9N A;  2R9M A;  5K16 A;  4G54 A;  1AYU A;  1PPO A;  3I06 A;  4Q8G A;  4X6H A;  1BGO A;  2DCA A;  4YVA A;  4KLB A;  2AU1 A;  3B79 A;  2YJ9 A;  2FO5 A;  2F7D A;  1CJL A;  1QDQ A;  3S3R A;  1O0E A;  4MSX A;  1BQI A;  2AYO A;  3P5V A;  2E03 A;  4FJC A;  4DMY A;  1JQP A;  1PPP A;  3WXG A;  5A24 A;  2H7J A;  1U5I A;  3PBH A;  2G7Y A;  2P0R A;  4OEM A;  5CVN B;  4OEL A;  1CS8 A;  2DZY A;  3KFQ A;  4AXM A;  4CDC B;  4P6G A;  1ATK A;  4CDF B;  1AU4 A;  3PNR A;  2G8E A;  2IBI A;  3H8C A;  3KKU A;  3CBJ A;  2P86 A;  3HWN A;  4RY2 A;  2YJ2 A;  2P7U A;  4WA6 A;  3KSE A;  3PW3 A;  2VHF A;  1ITO A;  2DJF B;  1EWM A;  2FUD A;  3BOW A;  3WXE A;  3E1Z B;  1PPD A;  6PAD A;  1XKG A;  4BS5 A;  3BWK A;  1GMY A;  1PAD A;  3KWB X;  2HH5 A;  4MZO A;  1YK8 A;  3BCN A;  3QSD A;  3H7D A;  4QBB A;  4YYS A;  1Y08 A;  2DZZ A;  4CDD B;  1PE6 A;  3D9W A;  1GLO A;  2PAD A;  1NPZ A;  2Y6E A;  3BC3 A;  1PIP A;  3O0U A;  4PAD A;  1ZCM A;  2C0Y A;  1AEC A;  2XU1 A;  2NQG A;  3GCB A;  1TU6 A;  4XR7 A;  3LFY A;  2DC9 A;  2DC6 A;  1EWL A;  5CHT A;  5JH3 A;  2XU5 A;  3BPF A;  3AI8 A;  3IUT A;  5J94 A;  4AXL A;  2YJ8 A;  3CH3 X;  1KFU L;  1F29 A;  3N4C A;  3S3Q A;  1NB3 A;  2VFC A;  1POP A;  1TLO A;  1KHQ A;  4PP1 A;  9PAP A;  1CSB B;  1KFX L;  4N4Z A;  4W5B A;  1F2C A;  1STF E;  4CDE B;  4I04 A;  4QRG A;  1EF7 A;  4PI3 A;  2OP3 A;  4GUZ A;  4YV8 A;  2DCD A;  1W6F A;  2CB5 A;  2G8J A;  3IEJ A;  1F2B A;  3V6C A;  4W5C A;  3OVX A;  4YYQ A;  2YJB A;  3KW9 A;  1YAL A;  3RVX A;  5JA7 A;  4PP2 E;  2F1G A;  2OZ2 A;  3D6S A;  4Q8H A;  1SNK A;  2FYE A;  4BPV A;  3IHP A;  1U9V A;  3V6E A;  3K24 A;  7PCK A;  1Q6K A;  2JQF R;  3H6S A;  3OIS A;  1MIR A;  1ME4 A;  2FT2 A;  1YT7 A;  4B55 A;  2R9C A;  1AU3 A;  2DCC A;  1IWD A;  3BPM A;  4YYU A;  2CIO A;  2DC7 A;  2GFO A;  1GEC E;  2E01 A;  5CVM A;  2E02 A;  2GHU A;  2PRE A;  1W4T A;  1ICF A;  1CQD A;  1S4V A;  2NQI A;  2AS8 A;  2FTD A;  4X6I A;  2VHS A;  3HD3 A;  3H8B A;  1BP4 A;  4W4U A;  3PDF A;  1YVB A;  4N8W A;  1U9Q X;  1K3B B;  3OF9 A;  2XU4 A;  3H89 A;  4BGF A;  2G6D A;  1VJV A;  2AUX A;  3LTW A;  2DCB A;  2B1N A;  2ARY A;  1KXR A;  1MS6 A;  3RVV A;  3K8U A;  2E00 A;  4ZUX U;  3IMA A;  1AU2 A;  1GX3 A;  3P5W A;  1NB5 A;  5EGW A;  1MHW A;  1NL6 A;  2PBH A;  4YYW A;  1CVZ A;  4YYR A;  3OF8 A;  4MZS A;  4BS6 A;  4K7C A;  1PPN A;  1KHP A;  1SP4 B;  1CPJ A;  5CHV A;  3USV A;  4BSQ A;  1MEG A;  1VSN A;  3IOQ A;  3P5X A;  1EWO A;  4P6E A;  3RVW A;  2DJG B;  3QJ3 A;  2BDZ A;  3MOR A;  2Y5B A;  3O1G A;  1BY8 A;  4FK5 A;  3HHA A;  1X9Y A;  2IPP B;  3CBK A;  2ACT A;  1YK7 A;  3F75 A;  2NQD B;  2BSZ A;  2FRQ A;  2R9F A;  5PAD A;  4N79 A;  1MDW A;  3MHS A;  4X6J A;  1EWP A;  4CZW A;  1AYV A;  2HHN A;  3ERV A;  4I07 A;  1DEU A;  3MTN A;  1CTE A;  2R9O A;  4BQV A;  2AIM A;  1TL9 A;  1U9W A;  3KWZ A;  1Y4H A;  3DF0 A;  1AYW A;  3IV2 A;  3CH2 X;  1ME3 A;  1QOL A;  1DF0 A;  1NQC A;  1MEM A;  1QXP A;  1U9X A;  2JQG R;  3F5V A;  4NV7 A;  1CB5 A;  3P5U A;  4C5P A;  2AUZ A;  2BDL A;  1W5R A;  1ZIV A;  4YYV A;  1E2T A;  1AIM A;  2OUL A;  8PCH A;  2DC8 A;  1THE A;  3QT4 A;  1HUC B;  1F2A A;  3KX1 A;  2PNS A;  2YJC A;  3TNX A;  3WXF A;  2HXZ A;  1CV8 A;  1PXV A;  3LXS A;  5F02 A;  4XUI A;  3OVZ A;  1PBH A;  3I3T A;  1AU0 A;  1NLJ A;  3K9M A;  4FIP A;  3N3K A;  4QRX A;  3C9E A;  2ATO A;  4QH6 A;  2B1M A;  2FQ9 A;  5FPW A;  2AYN A;  5EF4 A;  4I05 A;  3N3G A;  2R6N A;  2XU3 A;  3NHE A;  1QMY A;  3ZUA A;  4QRV A;  2VFB A;  4NV8 A;  2O6X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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