1TLOA

High resolution crystal structure of calpain i protease core in complex with e64
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
322
structure length
322
Chain Sequence
NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Calpain 1, large [catalytic] subunit
publication title Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site
pubmed doi rcsb
source organism Rattus norvegicus
molecule tags Hydrolase
total genus 95
structure length 322
sequence length 322
ec nomenclature ec 3.4.22.52: Calpain-1.
pdb deposition date 2004-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00648 Peptidase_C2 Calpain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1tloA02
2GFOA 2IPPB 2DCCA 1PPPA 3CH2X 4P6GA 2ACTA 3IHPA 4RY2A 4I07A 5CHVA 1K3BB 2WBFX 2FRQA 2XU3A 2G8JA 3D6SA 4PI3A 1POPA 4AXMA 2FYEA 2DCAA 2F1GA 4FJCA 1YVBA 2PADA 5A24A 3TNXA 1HUCB 4AXLA 3MHHA 1QMYA 4X6JA 1O0EA 3CBJA 2E01A 2OP3A 2E00A 1EWLA 2CB5A 2DJGB 1EWPA 2DJFB 2G7YA 5CVMA 2DCDA 1ITOA 1A6RA 9PAPA 4DMYA 3KWBX 2DZYA 4I04A 3V6CA 4OELA 3GCBA 2R9NA 3RVVA 2XU5A 4QRVA 4MZOA 2PBHA 4XR7A 2Y6EA 1AYWA 1YALA 4WA6A 1VSNA 2BDLA 4N79A 2R9FA 1MS6A 1YK7A 1MEGA 1CVZA 4BS6A 3C9EA 4FIPA 3IEJA 1NB5A 4QBBA 2BDZA 3P5UA 2NQDB 3H7DA 4W5CA 1GCBA 3WXGA 1ICFA 1PE6A 1NLJA 6PADA 4BS5A 3MTNA 1AU0A 1PIPA 5K16A 3F5VA 2F7DA 1KFXL 2YJ2A 3IOQA 3V6EA 4N4ZA 1EF7A 1NPZA 1ATKA 2B1MA 2P7UA 4X6HA 3OVZA 1CPJA 3N3GA 1CJLA 2ARYA 2DC6A 2C0YA 3RVWA 1AU3A 2FT2A 2FUDA 3KWZA 1X9YA 3IUTA 1F2BA 4CDCB 1THEA 4QRXA 3WXFA 4XUIA 3U8EA 2AU1A 1MEMA 1AU2A 1EWMA 2OULA 3AI8A 1U9WA 2G6DA 3PNRA 2AS8A 1SNKA 1CB5A 4YVAA 2DC7A 3OVXA 1U9VA 5J94A 1AU4A 2E02A 1STFE 4PADA 4QRGA 4CDEB 5PADA 3K8UA 3IMAA 2H7JA 2VHFA 5CHTA 1TL9A 1FH0A 2DC8A 4HWYA 3H89A 3BC3A 4CZWA 3H6SA 2DCBA 3QT4A 2XU1A 2B1NA 4YYSA 4ZUXU 2AVWA 1DF0A 5FPWA 1AYVA 3LFYA 3HHIA 1KFUL 2XU4A 3PDFA 1F2CA 2JQGR 3MORA 4PP2E 1CV8A 2AYOA 1ME3A 1MHWA 3I06A 2AUXA 2PNSA 1F29A 1AECA 2NQIA 3BCNA 3PBHA 4N8WA 5JH3A 3RVXA 2YJBA 3HHAA 3ZUAA 4YV8A 1CSBB 2FO5A 5EGWA 4YYVA 4W5BA 7PCKA 1BP4A 1Q6KA 1KXRA 1NQCA 4YYQA 3K9MA 3H8BA 1GECE 3MHSA 2DC9A 4YYWA 1S4VA 3BPMA 1PPOA 3DF0A 2PREA 3QSDA 1GMYA 2IBIA 2VHSA 2P0RA 5CVNB 4BQVA 4MSXA 3OISA 4G54A 3O1GA 1BQIA 4KLBA 3BWKA 1AYUA 1QOLA 3LXSA 4I05A 4Q8HA 1PBHA 4MZSA 3KSEA 3QJ3A 5JA7A 1U9QX 2FQ9A 3H8CA 1MDWA 2R6NA 4DMXA 4YYUA 1ZCMA 3CH3X 4CDFB 1U5IA 2DZZA 1IWDA 1KHPA 3OF9A 2HH5A 1PXVA 3ERVA 2AIMA 2HHNA 1JQPA 1KHQA 2YJCA 2JQFR 1ME4A 4Q8GA 3BOWA 1M6DA 2AUZA 1BY8A 4P6EA 2CIOA 2GHUA 1SP4B 1Y08A 2NQGA 1PADA 3BPFA 1GLOA 3KX1A 4X6IA 4BPVA 3S3RA 1U9XA 1CS8A 4FK5A 2YJ8A 8PCHA 1F2AA 4PP1A 3B79A 2AYNA 1BGOA 2R9OA 2P86A 2NQAA 2G8EA 1CQDA 2R9MA 4BSQA 2Y5BA 3KFQA 1VJVA 3F75A 3N4CA 3PW3A 3S3QA 3KW9A 5F02A 4K7CA 2E03A 3P5XA 5CVOB 3O0UA 1QXPA 3NHEA 4OEMA 3P5WA 1Y4HA 2HXZA 3IV2A 3E1ZB 3I3TA 2HD5A 1PPNA 2R9CA 4CDDB 1ZIVA 2FTDA 1XKGA 4YYRA 3M99A 1AIMA 1CTEA 2YJ9A 2OZ2A 1MIRA 4QH6A 3HWNA 5EF4A 1PCIA 1PPDA 1TU6A 1NB3A 1TLOA 3KKUA 1YT7A 3USVA 1DEUA 1NL6A 3OF8A 3P5VA 2ATOA 3WXEA 1QDQA 3CBKA 2O6XA 3HD3A 3N3KA 1YK8A 2FRAA 4W4UA 3K24A 1EWOA
chains in the Genus database with same CATH superfamily
2GFOA 2IPPB 2DCCA 1PPPA 3CH2X 4P6GA 2ACTA 3IHPA 4RY2A 4BOSA 4I07A 5CHVA 1K3BB 2WBFX 2FRQA 2XU3A 2G8JA 3D6SA 4PI3A 1POPA 4AXMA 2FYEA 4RF1A 2DCAA 2F1GA 4FJCA 1YVBA 2PADA 5A24A 3TNXA 1HUCB 4AXLA 3MHHA 3BY4A 1QMYA 4MI7A 4X6JA 1O0EA 4OVZA 2FE8A 3CBJA 2E01A 4HXDB 2OP3A 2E00A 1EWLA 2CB5A 2DJGB 1EWPA 2DJFB 2G7YA 5CVMA 3MP2A 2DCDA 1ITOA 1A6RA 9PAPA 4DMYA 3KWBX 2DZYA 4I04A 3V6CA 4OELA 3GCBA 2R9NA 3RVVA 2XU5A 4QRVA 4MZOA 4PT5A 2PBHA 4XR7A 2Y6EA 3E9SA 1AYWA 1YALA 4WA6A 1VSNA 2BDLA 4N79A 2R9FA 1MS6A 3TMPA 1YK7A 1MEGA 1CVZA 4BS6A 3C9EA 4FIPA 3IEJA 1NB5A 3RNVA 4IP3A 4QBBA 2BDZA 3P5UA 3TRKA 2NQDB 3H7DA 4W5CA 1GCBA 4BOUA 3WXGA 1ICFA 1PE6A 1NLJA 6PADA 4BS5A 3MTNA 1AU0A 1PIPA 5K16A 3F5VA 2F7DA 1KFXL 2YJ2A 3IOQA 3V6EA 1EF7A 1NPZA 4N4ZA 1ATKA 2B1MA 2P7UA 4X6HA 4ZTBA 4BOZA 4M0WA 5JZEA 3OVZA 1CPJA 3N3GA 4OVZB 1CJLA 2ARYA 2DC6A 3OQCA 2C0YA 3RVWA 2BTWB 1AU3A 2BU3A 2FT2A 2FUDA 3KWZA 2JRIA 1X9YA 4MM3B 3IUTA 1F2BA 4CDCB 2HWKA 1THEA 4QRXA 1YZBA 3WXFA 4XUIA 3U8EA 2AU1A 1MEMA 1AU2A 1EWMA 2OULA 3AI8A 1U9WA 2G6DA 5EZSA 4REZA 3B21A 3PHWA 4P16A 1PVJA 3PNRA 2AS8A 1SNKA 1CB5A 4YVAA 2DC7A 3OVXA 1U9VA 5J94A 1AU4A 3MJ5A 2E02A 1STFE 4PADA 4QRGA 4CDEB 5PADA 3K8UA 1UKFA 3IMAA 2H7JA 2VHFA 4RNAA 5CHTA 2DOSA 3PHXA 1TL9A 1FH0A 2DC8A 4HWYA 3H89A 3BC3A 4CZWA 4XZXA 3H6SA 2DCBA 3QT4A 2XU1A 2J7QA 3PRMA 2B1NA 4YYSA 4ZUXU 2AVWA 1DF0A 5FPWA 1AYVA 3LFYA 3HHIA 3BBAA 1KFUL 2XU4A 3PDFA 1F2CA 2JQGR 3MORA 3PSEA 4PP2E 5E6JA 1CV8A 2AYOA 1ME3A 1MHWA 3I06A 2AUXA 2PNSA 1F29A 1AECA 2NQIA 3BCNA 3PBHA 4N8WA 5JH3A 3RVXA 2YJBA 3HHAA 3ZUAA 4YV8A 1CSBB 2FO5A 5EGWA 4YYVA 4W5BA 7PCKA 2JTCA 1BP4A 1Q6KA 3PRPA 1KXRA 3BB7A 1NQCA 4YYQA 3K9MA 3H8BA 1GECE 3MHSA 2DC9A 4YYWA 1S4VA 3BPMA 1PPOA 3DF0A 2PREA 3QSDA 1GMYA 4RF0A 2IBIA 2VHSA 2P0RA 5CVNB 3MTVA 4BQVA 4RKXA 4MSXA 3OISA 4G54A 3O1GA 3O65A 1BQIA 4KLBA 3BWKA 1AYUA 1QOLA 3LXSA 3W30A 4I05A 4Q8HA 1PBHA 4MZSA 3KSEA 3QJ3A 5JA7A 1U9QX 2FQ9A 3H8CA 1MDWA 2R6NA 4DMXA 5KO3A 4YYUA 1ZCMA 3CH3X 4CDFB 1U5IA 2DZZA 1IWDA 1KHPA 3OF9A 2HH5A 1PXVA 3ERVA 2AIMA 2HHNA 1JQPA 1KHQA 2YJCA 2JQFR 1ME4A 2J7QC 4Q8GA 3BOWA 1M6DA 2AUZA 1BY8A 4P6EA 2CIOA 2GHUA 1SP4B 1Y08A 2NQGA 1PADA 3IFUA 3BPFA 1GLOA 3KX1A 4X6IA 4BPVA 3S3RA 1U9XA 2BTWA 3W31A 1CS8A 4D8BA 4FK5A 2YJ8A 8PCHA 1F2AA 4D8EA 4PP1A 1DKIA 3B79A 2AYNA 1BGOA 2R9OA 2P86A 2NQAA 2G8EA 1CQDA 2R9MA 4BSQA 2Y5BA 3KFQA 1VJVA 3F75A 4D8IA 3N4CA 3PW3A 4GUAA 3S3QA 3KW9A 5F02A 4K7CA 4BOQA 2E03A 3P5XA 5CVOB 3PHUA 3O0UA 1QXPA 3NHEA 2Z84A 4OEMA 3P5WA 1Y4HA 2HXZA 3IV2A 3E1ZB 3I3TA 4A5UA 2HD5A 2AGAA 1PPNA 2R9CA 4CDDB 4OW0A 1ZIVA 4IUMA 2FTDA 1XKGA 4YYRA 3C0RA 3M99A 4R3DA 1AIMA 1CTEA 2YJ9A 2OZ2A 4BOPA 1MIRA 4QH6A 3HWNA 5EZQA 5EF4A 1PCIA 1PPDA 2UZJA 1TU6A 1NB3A 1TLOA 3KKUA 1YT7A 3USVA 1DEUA 1NL6A 3OF8A 3P5VA 2ATOA 4WURA 3WXEA 3PT2A 1QDQA 3CBKA 2O6XA 3ZNHA 3HD3A 3N3KA 1YK8A 2FRAA 4W4UA 3K24A 1EWOA
chains in the Genus database with same CATH topology
4NV8A 2GFOA 2IPPB 2DCCA 1PPPA 3CH2X 4P6GA 2ACTA 3IHPA 4RY2A 4I07A 5CHVA 1K3BB 2WBFX 2FRQA 2XU3A 2G8JA 3D6SA 4PI3A 1POPA 4AXMA 2FYEA 2DCAA 2F1GA 4FJCA 1YVBA 2PADA 5A24A 3TNXA 1HUCB 4AXLA 3MHHA 1QMYA 4X6JA 1O0EA 3CBJA 2E01A 2OP3A 2E00A 1EWLA 2CB5A 2DJGB 1EWPA 2DJFB 2G7YA 5CVMA 2DCDA 1ITOA 1A6RA 9PAPA 4DMYA 3KWBX 2DZYA 4I04A 3V6CA 4OELA 3GCBA 2R9NA 3RVVA 2XU5A 4QRVA 4MZOA 2PBHA 4XR7A 2Y6EA 1AYWA 1YALA 4WA6A 1VSNA 2BDLA 4N79A 2R9FA 1MS6A 1YK7A 1MEGA 1CVZA 4BS6A 3C9EA 4FIPA 3IEJA 1NB5A 4QBBA 2BDZA 3P5UA 2NQDB 3H7DA 4W5CA 1GCBA 3WXGA 1ICFA 1PE6A 1NLJA 6PADA 1W5RA 4BS5A 3D9WA 3MTNA 1AU0A 1PIPA 5K16A 3F5VA 2F7DA 1KFXL 2YJ2A 3IOQA 3V6EA 4N4ZA 1EF7A 1NPZA 1ATKA 2B1MA 2P7UA 4X6HA 3OVZA 1CPJA 3N3GA 1CJLA 2ARYA 2DC6A 2C0YA 3RVWA 1AU3A 2FT2A 2FUDA 3KWZA 1X9YA 3IUTA 4C5PA 1F2BA 4CDCB 1THEA 4QRXA 3WXFA 4XUIA 3U8EA 2AU1A 1MEMA 1AU2A 1EWMA 2OULA 3AI8A 1U9WA 2G6DA 3PNRA 2AS8A 1SNKA 1CB5A 4YVAA 2DC7A 3OVXA 1U9VA 5J94A 1AU4A 2E02A 1STFE 4PADA 4QRGA 4CDEB 5PADA 3K8UA 3IMAA 2H7JA 2VHFA 5CHTA 1TL9A 1FH0A 2DC8A 4HWYA 3H89A 3BC3A 4CZWA 3H6SA 2DCBA 3QT4A 2XU1A 2B1NA 4YYSA 4ZUXU 2AVWA 1DF0A 5FPWA 1AYVA 3LFYA 3HHIA 1KFUL 2XU4A 3PDFA 1F2CA 2JQGR 3MORA 4PP2E 1CV8A 2AYOA 1ME3A 1MHWA 2VFCA 3I06A 2AUXA 2PNSA 1F29A 1AECA 2NQIA 3BCNA 3PBHA 4N8WA 5JH3A 3RVXA 2YJBA 3HHAA 4NV7A 3ZUAA 4YV8A 1CSBB 2FO5A 5EGWA 4YYVA 4W5BA 7PCKA 1W6FA 1BP4A 1Q6KA 1KXRA 1NQCA 4YYQA 1GX3A 3K9MA 3H8BA 1GECE 3MHSA 2DC9A 4YYWA 1S4VA 3BPMA 1PPOA 3DF0A 2PREA 3QSDA 1GMYA 2IBIA 2VHSA 2P0RA 5CVNB 4BQVA 4MSXA 3OISA 4G54A 3O1GA 1BQIA 1E2TA 4KLBA 3BWKA 1AYUA 1QOLA 3LXSA 4I05A 4Q8HA 1PBHA 4MZSA 3KSEA 3QJ3A 5JA7A 1U9QX 2FQ9A 3H8CA 1MDWA 2R6NA 4DMXA 4YYUA 1ZCMA 3CH3X 4CDFB 1U5IA 2DZZA 1IWDA 1KHPA 3OF9A 2HH5A 1PXVA 3ERVA 2AIMA 2HHNA 1JQPA 1KHQA 2YJCA 2JQFR 1ME4A 4Q8GA 3BOWA 1M6DA 2AUZA 1W4TA 1BY8A 4P6EA 2CIOA 2GHUA 2BSZA 1SP4B 1Y08A 2NQGA 1PADA 3BPFA 1GLOA 3KX1A 4X6IA 4BPVA 2VFBA 3S3RA 1U9XA 1CS8A 4FK5A 2YJ8A 8PCHA 1F2AA 4PP1A 3B79A 2AYNA 1BGOA 2R9OA 2P86A 2NQAA 2G8EA 1CQDA 2R9MA 4BSQA 2Y5BA 3KFQA 1VJVA 3F75A 3N4CA 3PW3A 3S3QA 3KW9A 5F02A 4K7CA 2E03A 3P5XA 5CVOB 3O0UA 1QXPA 3NHEA 4OEMA 3P5WA 1Y4HA 2HXZA 3IV2A 3E1ZB 3I3TA 2HD5A 1PPNA 2R9CA 4CDDB 1ZIVA 2FTDA 1XKGA 4YYRA 3M99A 1AIMA 1CTEA 4B55A 2YJ9A 2OZ2A 1MIRA 4QH6A 3HWNA 5EF4A 1PCIA 1PPDA 4BGFA 1TU6A 1NB3A 1TLOA 3KKUA 1YT7A 3USVA 1DEUA 1NL6A 3OF8A 3P5VA 2ATOA 3LTWA 3WXEA 1QDQA 3CBKA 2O6XA 3HD3A 3N3KA 1YK8A 2FRAA 4W4UA 3K24A 4GUZA 1EWOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GFO A;  2IPP B;  2DCC A;  1PPP A;  3CH2 X;  4P6G A;  2ACT A;  3IHP A;  4RY2 A;  4I07 A;  5CHV A;  1K3B B;  2WBF X;  2FRQ A;  2XU3 A;  2G8J A;  3D6S A;  4PI3 A;  1POP A;  4AXM A;  2FYE A;  2DCA A;  2F1G A;  4FJC A;  1YVB A;  2PAD A;  5A24 A;  3TNX A;  1HUC B;  4AXL A;  3MHH A;  1QMY A;  4X6J A;  1O0E A;  3CBJ A;  2E01 A;  2OP3 A;  2E00 A;  1EWL A;  2CB5 A;  2DJG B;  1EWP A;  2DJF B;  2G7Y A;  5CVM A;  2DCD A;  1ITO A;  1A6R A;  9PAP A;  4DMY A;  3KWB X;  2DZY A;  4I04 A;  3V6C A;  4OEL A;  3GCB A;  2R9N A;  3RVV A;  2XU5 A;  4QRV A;  4MZO A;  2PBH A;  4XR7 A;  2Y6E A;  1AYW A;  1YAL A;  4WA6 A;  1VSN A;  2BDL A;  4N79 A;  2R9F A;  1MS6 A;  1YK7 A;  1MEG A;  1CVZ A;  4BS6 A;  3C9E A;  4FIP A;  3IEJ A;  1NB5 A;  4QBB A;  2BDZ A;  3P5U A;  2NQD B;  3H7D A;  4W5C A;  1GCB A;  3WXG A;  1ICF A;  1PE6 A;  1NLJ A;  6PAD A;  4BS5 A;  3MTN A;  1AU0 A;  1PIP A;  5K16 A;  3F5V A;  2F7D A;  1KFX L;  2YJ2 A;  3IOQ A;  3V6E A;  4N4Z A;  1EF7 A;  1NPZ A;  1ATK A;  2B1M A;  2P7U A;  4X6H A;  3OVZ A;  1CPJ A;  3N3G A;  1CJL A;  2ARY A;  2DC6 A;  2C0Y A;  3RVW A;  1AU3 A;  2FT2 A;  2FUD A;  3KWZ A;  1X9Y A;  3IUT A;  1F2B A;  4CDC B;  1THE A;  4QRX A;  3WXF A;  4XUI A;  3U8E A;  2AU1 A;  1MEM A;  1AU2 A;  1EWM A;  2OUL A;  3AI8 A;  1U9W A;  2G6D A;  3PNR A;  2AS8 A;  1SNK A;  1CB5 A;  4YVA A;  2DC7 A;  3OVX A;  1U9V A;  5J94 A;  1AU4 A;  2E02 A;  1STF E;  4PAD A;  4QRG A;  4CDE B;  5PAD A;  3K8U A;  3IMA A;  2H7J A;  2VHF A;  5CHT A;  1TL9 A;  1FH0 A;  2DC8 A;  4HWY A;  3H89 A;  3BC3 A;  4CZW A;  3H6S A;  2DCB A;  3QT4 A;  2XU1 A;  2B1N A;  4YYS A;  4ZUX U;  2AVW A;  1DF0 A;  5FPW A;  1AYV A;  3LFY A;  3HHI A;  1KFU L;  2XU4 A;  3PDF A;  1F2C A;  2JQG R;  3MOR A;  4PP2 E;  1CV8 A;  2AYO A;  1ME3 A;  1MHW A;  3I06 A;  2AUX A;  2PNS A;  1F29 A;  1AEC A;  2NQI A;  3BCN A;  3PBH A;  4N8W A;  5JH3 A;  3RVX A;  2YJB A;  3HHA A;  3ZUA A;  4YV8 A;  1CSB B;  2FO5 A;  5EGW A;  4YYV A;  4W5B A;  7PCK A;  1BP4 A;  1Q6K A;  1KXR A;  1NQC A;  4YYQ A;  3K9M A;  3H8B A;  1GEC E;  3MHS A;  2DC9 A;  4YYW A;  1S4V A;  3BPM A;  1PPO A;  3DF0 A;  2PRE A;  3QSD A;  1GMY A;  2IBI A;  2VHS A;  2P0R A;  5CVN B;  4BQV A;  4MSX A;  3OIS A;  4G54 A;  3O1G A;  1BQI A;  4KLB A;  3BWK A;  1AYU A;  1QOL A;  3LXS A;  4I05 A;  4Q8H A;  1PBH A;  4MZS A;  3KSE A;  3QJ3 A;  5JA7 A;  1U9Q X;  2FQ9 A;  3H8C A;  1MDW A;  2R6N A;  4DMX A;  4YYU A;  1ZCM A;  3CH3 X;  4CDF B;  1U5I A;  2DZZ A;  1IWD A;  1KHP A;  3OF9 A;  2HH5 A;  1PXV A;  3ERV A;  2AIM A;  2HHN A;  1JQP A;  1KHQ A;  2YJC A;  2JQF R;  1ME4 A;  4Q8G A;  3BOW A;  1M6D A;  2AUZ A;  1BY8 A;  4P6E A;  2CIO A;  2GHU A;  1SP4 B;  1Y08 A;  2NQG A;  1PAD A;  3BPF A;  1GLO A;  3KX1 A;  4X6I A;  4BPV A;  3S3R A;  1U9X A;  1CS8 A;  4FK5 A;  2YJ8 A;  8PCH A;  1F2A A;  4PP1 A;  3B79 A;  2AYN A;  1BGO A;  2R9O A;  2P86 A;  2NQA A;  2G8E A;  1CQD A;  2R9M A;  4BSQ A;  2Y5B A;  3KFQ A;  1VJV A;  3F75 A;  3N4C A;  3PW3 A;  3S3Q A;  3KW9 A;  5F02 A;  4K7C A;  2E03 A;  3P5X A;  5CVO B;  3O0U A;  1QXP A;  3NHE A;  4OEM A;  3P5W A;  1Y4H A;  2HXZ A;  3IV2 A;  3E1Z B;  3I3T A;  2HD5 A;  1PPN A;  2R9C A;  4CDD B;  1ZIV A;  2FTD A;  1XKG A;  4YYR A;  3M99 A;  1AIM A;  1CTE A;  2YJ9 A;  2OZ2 A;  1MIR A;  4QH6 A;  3HWN A;  5EF4 A;  1PCI A;  1PPD A;  1TU6 A;  1NB3 A;  1TLO A;  3KKU A;  1YT7 A;  3USV A;  1DEU A;  1NL6 A;  3OF8 A;  3P5V A;  2ATO A;  3WXE A;  1QDQ A;  3CBK A;  2O6X A;  3HD3 A;  3N3K A;  1YK8 A;  2FRA A;  4W4U A;  3K24 A;  1EWO A; 
#chains in the Genus database with same CATH topology
 2GFO A;  2IPP B;  2DCC A;  1PPP A;  3CH2 X;  4P6G A;  2ACT A;  3IHP A;  4RY2 A;  4BOS A;  4I07 A;  5CHV A;  1K3B B;  2WBF X;  2FRQ A;  2XU3 A;  2G8J A;  3D6S A;  4PI3 A;  1POP A;  4AXM A;  2FYE A;  4RF1 A;  2DCA A;  2F1G A;  4FJC A;  1YVB A;  2PAD A;  5A24 A;  3TNX A;  1HUC B;  4AXL A;  3MHH A;  3BY4 A;  1QMY A;  4MI7 A;  4X6J A;  1O0E A;  4OVZ A;  2FE8 A;  3CBJ A;  2E01 A;  4HXD B;  2OP3 A;  2E00 A;  1EWL A;  2CB5 A;  2DJG B;  1EWP A;  2DJF B;  2G7Y A;  5CVM A;  3MP2 A;  2DCD A;  1ITO A;  1A6R A;  9PAP A;  4DMY A;  3KWB X;  2DZY A;  4I04 A;  3V6C A;  4OEL A;  3GCB A;  2R9N A;  3RVV A;  2XU5 A;  4QRV A;  4MZO A;  4PT5 A;  2PBH A;  4XR7 A;  2Y6E A;  3E9S A;  1AYW A;  1YAL A;  4WA6 A;  1VSN A;  2BDL A;  4N79 A;  2R9F A;  1MS6 A;  3TMP A;  1YK7 A;  1MEG A;  1CVZ A;  4BS6 A;  3C9E A;  4FIP A;  3IEJ A;  1NB5 A;  3RNV A;  4IP3 A;  4QBB A;  2BDZ A;  3P5U A;  3TRK A;  2NQD B;  3H7D A;  4W5C A;  1GCB A;  4BOU A;  3WXG A;  1ICF A;  1PE6 A;  1NLJ A;  6PAD A;  4BS5 A;  3MTN A;  1AU0 A;  1PIP A;  5K16 A;  3F5V A;  2F7D A;  1KFX L;  2YJ2 A;  3IOQ A;  3V6E A;  1EF7 A;  1NPZ A;  4N4Z A;  1ATK A;  2B1M A;  2P7U A;  4X6H A;  4ZTB A;  4BOZ A;  4M0W A;  5JZE A;  3OVZ A;  1CPJ A;  3N3G A;  4OVZ B;  1CJL A;  2ARY A;  2DC6 A;  3OQC A;  2C0Y A;  3RVW A;  2BTW B;  1AU3 A;  2BU3 A;  2FT2 A;  2FUD A;  3KWZ A;  2JRI A;  1X9Y A;  4MM3 B;  3IUT A;  1F2B A;  4CDC B;  2HWK A;  1THE A;  4QRX A;  1YZB A;  3WXF A;  4XUI A;  3U8E A;  2AU1 A;  1MEM A;  1AU2 A;  1EWM A;  2OUL A;  3AI8 A;  1U9W A;  2G6D A;  5EZS A;  4REZ A;  3B21 A;  3PHW A;  4P16 A;  1PVJ A;  3PNR A;  2AS8 A;  1SNK A;  1CB5 A;  4YVA A;  2DC7 A;  3OVX A;  1U9V A;  5J94 A;  1AU4 A;  3MJ5 A;  2E02 A;  1STF E;  4PAD A;  4QRG A;  4CDE B;  5PAD A;  3K8U A;  1UKF A;  3IMA A;  2H7J A;  2VHF A;  4RNA A;  5CHT A;  2DOS A;  3PHX A;  1TL9 A;  1FH0 A;  2DC8 A;  4HWY A;  3H89 A;  3BC3 A;  4CZW A;  4XZX A;  3H6S A;  2DCB A;  3QT4 A;  2XU1 A;  2J7Q A;  3PRM A;  2B1N A;  4YYS A;  4ZUX U;  2AVW A;  1DF0 A;  5FPW A;  1AYV A;  3LFY A;  3HHI A;  3BBA A;  1KFU L;  2XU4 A;  3PDF A;  1F2C A;  2JQG R;  3MOR A;  3PSE A;  4PP2 E;  5E6J A;  1CV8 A;  2AYO A;  1ME3 A;  1MHW A;  3I06 A;  2AUX A;  2PNS A;  1F29 A;  1AEC A;  2NQI A;  3BCN A;  3PBH A;  4N8W A;  5JH3 A;  3RVX A;  2YJB A;  3HHA A;  3ZUA A;  4YV8 A;  1CSB B;  2FO5 A;  5EGW A;  4YYV A;  4W5B A;  7PCK A;  2JTC A;  1BP4 A;  1Q6K A;  3PRP A;  1KXR A;  3BB7 A;  1NQC A;  4YYQ A;  3K9M A;  3H8B A;  1GEC E;  3MHS A;  2DC9 A;  4YYW A;  1S4V A;  3BPM A;  1PPO A;  3DF0 A;  2PRE A;  3QSD A;  1GMY A;  4RF0 A;  2IBI A;  2VHS A;  2P0R A;  5CVN B;  3MTV A;  4BQV A;  4RKX A;  4MSX A;  3OIS A;  4G54 A;  3O1G A;  3O65 A;  1BQI A;  4KLB A;  3BWK A;  1AYU A;  1QOL A;  3LXS A;  3W30 A;  4I05 A;  4Q8H A;  1PBH A;  4MZS A;  3KSE A;  3QJ3 A;  5JA7 A;  1U9Q X;  2FQ9 A;  3H8C A;  1MDW A;  2R6N A;  4DMX A;  5KO3 A;  4YYU A;  1ZCM A;  3CH3 X;  4CDF B;  1U5I A;  2DZZ A;  1IWD A;  1KHP A;  3OF9 A;  2HH5 A;  1PXV A;  3ERV A;  2AIM A;  2HHN A;  1JQP A;  1KHQ A;  2YJC A;  2JQF R;  1ME4 A;  2J7Q C;  4Q8G A;  3BOW A;  1M6D A;  2AUZ A;  1BY8 A;  4P6E A;  2CIO A;  2GHU A;  1SP4 B;  1Y08 A;  2NQG A;  1PAD A;  3IFU A;  3BPF A;  1GLO A;  3KX1 A;  4X6I A;  4BPV A;  3S3R A;  1U9X A;  2BTW A;  3W31 A;  1CS8 A;  4D8B A;  4FK5 A;  2YJ8 A;  8PCH A;  1F2A A;  4D8E A;  4PP1 A;  1DKI A;  3B79 A;  2AYN A;  1BGO A;  2R9O A;  2P86 A;  2NQA A;  2G8E A;  1CQD A;  2R9M A;  4BSQ A;  2Y5B A;  3KFQ A;  1VJV A;  3F75 A;  4D8I A;  3N4C A;  3PW3 A;  4GUA A;  3S3Q A;  3KW9 A;  5F02 A;  4K7C A;  4BOQ A;  2E03 A;  3P5X A;  5CVO B;  3PHU A;  3O0U A;  1QXP A;  3NHE A;  2Z84 A;  4OEM A;  3P5W A;  1Y4H A;  2HXZ A;  3IV2 A;  3E1Z B;  3I3T A;  4A5U A;  2HD5 A;  2AGA A;  1PPN A;  2R9C A;  4CDD B;  4OW0 A;  1ZIV A;  4IUM A;  2FTD A;  1XKG A;  4YYR A;  3C0R A;  3M99 A;  4R3D A;  1AIM A;  1CTE A;  2YJ9 A;  2OZ2 A;  4BOP A;  1MIR A;  4QH6 A;  3HWN A;  5EZQ A;  5EF4 A;  1PCI A;  1PPD A;  2UZJ A;  1TU6 A;  1NB3 A;  1TLO A;  3KKU A;  1YT7 A;  3USV A;  1DEU A;  1NL6 A;  3OF8 A;  3P5V A;  2ATO A;  4WUR A;  3WXE A;  3PT2 A;  1QDQ A;  3CBK A;  2O6X A;  3ZNH A;  3HD3 A;  3N3K A;  1YK8 A;  2FRA A;  4W4U A;  3K24 A;  1EWO A; 
#chains in the Genus database with same CATH homology
 4NV8 A;  2GFO A;  2IPP B;  2DCC A;  1PPP A;  3CH2 X;  4P6G A;  2ACT A;  3IHP A;  4RY2 A;  4I07 A;  5CHV A;  1K3B B;  2WBF X;  2FRQ A;  2XU3 A;  2G8J A;  3D6S A;  4PI3 A;  1POP A;  4AXM A;  2FYE A;  2DCA A;  2F1G A;  4FJC A;  1YVB A;  2PAD A;  5A24 A;  3TNX A;  1HUC B;  4AXL A;  3MHH A;  1QMY A;  4X6J A;  1O0E A;  3CBJ A;  2E01 A;  2OP3 A;  2E00 A;  1EWL A;  2CB5 A;  2DJG B;  1EWP A;  2DJF B;  2G7Y A;  5CVM A;  2DCD A;  1ITO A;  1A6R A;  9PAP A;  4DMY A;  3KWB X;  2DZY A;  4I04 A;  3V6C A;  4OEL A;  3GCB A;  2R9N A;  3RVV A;  2XU5 A;  4QRV A;  4MZO A;  2PBH A;  4XR7 A;  2Y6E A;  1AYW A;  1YAL A;  4WA6 A;  1VSN A;  2BDL A;  4N79 A;  2R9F A;  1MS6 A;  1YK7 A;  1MEG A;  1CVZ A;  4BS6 A;  3C9E A;  4FIP A;  3IEJ A;  1NB5 A;  4QBB A;  2BDZ A;  3P5U A;  2NQD B;  3H7D A;  4W5C A;  1GCB A;  3WXG A;  1ICF A;  1PE6 A;  1NLJ A;  6PAD A;  1W5R A;  4BS5 A;  3D9W A;  3MTN A;  1AU0 A;  1PIP A;  5K16 A;  3F5V A;  2F7D A;  1KFX L;  2YJ2 A;  3IOQ A;  3V6E A;  4N4Z A;  1EF7 A;  1NPZ A;  1ATK A;  2B1M A;  2P7U A;  4X6H A;  3OVZ A;  1CPJ A;  3N3G A;  1CJL A;  2ARY A;  2DC6 A;  2C0Y A;  3RVW A;  1AU3 A;  2FT2 A;  2FUD A;  3KWZ A;  1X9Y A;  3IUT A;  4C5P A;  1F2B A;  4CDC B;  1THE A;  4QRX A;  3WXF A;  4XUI A;  3U8E A;  2AU1 A;  1MEM A;  1AU2 A;  1EWM A;  2OUL A;  3AI8 A;  1U9W A;  2G6D A;  3PNR A;  2AS8 A;  1SNK A;  1CB5 A;  4YVA A;  2DC7 A;  3OVX A;  1U9V A;  5J94 A;  1AU4 A;  2E02 A;  1STF E;  4PAD A;  4QRG A;  4CDE B;  5PAD A;  3K8U A;  3IMA A;  2H7J A;  2VHF A;  5CHT A;  1TL9 A;  1FH0 A;  2DC8 A;  4HWY A;  3H89 A;  3BC3 A;  4CZW A;  3H6S A;  2DCB A;  3QT4 A;  2XU1 A;  2B1N A;  4YYS A;  4ZUX U;  2AVW A;  1DF0 A;  5FPW A;  1AYV A;  3LFY A;  3HHI A;  1KFU L;  2XU4 A;  3PDF A;  1F2C A;  2JQG R;  3MOR A;  4PP2 E;  1CV8 A;  2AYO A;  1ME3 A;  1MHW A;  2VFC A;  3I06 A;  2AUX A;  2PNS A;  1F29 A;  1AEC A;  2NQI A;  3BCN A;  3PBH A;  4N8W A;  5JH3 A;  3RVX A;  2YJB A;  3HHA A;  4NV7 A;  3ZUA A;  4YV8 A;  1CSB B;  2FO5 A;  5EGW A;  4YYV A;  4W5B A;  7PCK A;  1W6F A;  1BP4 A;  1Q6K A;  1KXR A;  1NQC A;  4YYQ A;  1GX3 A;  3K9M A;  3H8B A;  1GEC E;  3MHS A;  2DC9 A;  4YYW A;  1S4V A;  3BPM A;  1PPO A;  3DF0 A;  2PRE A;  3QSD A;  1GMY A;  2IBI A;  2VHS A;  2P0R A;  5CVN B;  4BQV A;  4MSX A;  3OIS A;  4G54 A;  3O1G A;  1BQI A;  1E2T A;  4KLB A;  3BWK A;  1AYU A;  1QOL A;  3LXS A;  4I05 A;  4Q8H A;  1PBH A;  4MZS A;  3KSE A;  3QJ3 A;  5JA7 A;  1U9Q X;  2FQ9 A;  3H8C A;  1MDW A;  2R6N A;  4DMX A;  4YYU A;  1ZCM A;  3CH3 X;  4CDF B;  1U5I A;  2DZZ A;  1IWD A;  1KHP A;  3OF9 A;  2HH5 A;  1PXV A;  3ERV A;  2AIM A;  2HHN A;  1JQP A;  1KHQ A;  2YJC A;  2JQF R;  1ME4 A;  4Q8G A;  3BOW A;  1M6D A;  2AUZ A;  1W4T A;  1BY8 A;  4P6E A;  2CIO A;  2GHU A;  2BSZ A;  1SP4 B;  1Y08 A;  2NQG A;  1PAD A;  3BPF A;  1GLO A;  3KX1 A;  4X6I A;  4BPV A;  2VFB A;  3S3R A;  1U9X A;  1CS8 A;  4FK5 A;  2YJ8 A;  8PCH A;  1F2A A;  4PP1 A;  3B79 A;  2AYN A;  1BGO A;  2R9O A;  2P86 A;  2NQA A;  2G8E A;  1CQD A;  2R9M A;  4BSQ A;  2Y5B A;  3KFQ A;  1VJV A;  3F75 A;  3N4C A;  3PW3 A;  3S3Q A;  3KW9 A;  5F02 A;  4K7C A;  2E03 A;  3P5X A;  5CVO B;  3O0U A;  1QXP A;  3NHE A;  4OEM A;  3P5W A;  1Y4H A;  2HXZ A;  3IV2 A;  3E1Z B;  3I3T A;  2HD5 A;  1PPN A;  2R9C A;  4CDD B;  1ZIV A;  2FTD A;  1XKG A;  4YYR A;  3M99 A;  1AIM A;  1CTE A;  4B55 A;  2YJ9 A;  2OZ2 A;  1MIR A;  4QH6 A;  3HWN A;  5EF4 A;  1PCI A;  1PPD A;  4BGF A;  1TU6 A;  1NB3 A;  1TLO A;  3KKU A;  1YT7 A;  3USV A;  1DEU A;  1NL6 A;  3OF8 A;  3P5V A;  2ATO A;  3LTW A;  3WXE A;  1QDQ A;  3CBK A;  2O6X A;  3HD3 A;  3N3K A;  1YK8 A;  2FRA A;  4W4U A;  3K24 A;  4GUZ A;  1EWO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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