4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Streptococcus pyogenes
molecule keywords Streptopain
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
4D8IA 2UZJA 2JTCA 3BB7A 4D8BA 4RKXA 3BBAA 1DKIA 1PVJA 4D8EA
chains in the Genus database with same CATH superfamily
1U9XA 1CTEA 4M0WA 1NLJA 4BPVA 5JA7A 4X6HA 4ZUXU 1VJVA 1QOLA 2JRIA 1YK7A 2GFOA 4RNAA 4REZA 1CS8A 9PAPA 4QRXA 5FPWA 4N4ZA 2AGAA 6PADA 2BTWB 2DC7A 3AI8A 3N3GA 2PREA 2G7YA 2PADA 4D8EA 1AIMA 3I06A 3PHUA 1MEGA 1AU4A 1F2AA 4YVAA 2J7QA 2NQGA 1PPDA 3MTNA 5E6JA 3M99A 3S3QA 4FIPA 2ATOA 1NB3A 2FRAA 4PI3A 2Z84A 4YYUA 1U5IA 1QMYA 3BPFA 2DZZA 4OVZA 2HH5A 5EZSA 1U9VA 1S4VA 2DC8A 3F75A 2DCDA 3N4CA 2E03A 3USVA 3HHAA 3E9SA 5EF4A 5CHTA 1Q6KA 1CJLA 4MZSA 4YV8A 3WXFA 3MP2A 4BQVA 3RNVA 3RVXA 3RVWA 2NQIA 4IUMA 1TL9A 3OF8A 1VSNA 3N3KA 1O0EA 2NQAA 2G8JA 3QSDA 1DF0A 3KKUA 4P16A 1GLOA 1CV8A 1PPOA 2C0YA 2R9OA 2FO5A 3S3RA 2HXZA 3HWNA 4BOPA 4W4UA 2B1NA 3MTVA 3LXSA 2YJ9A 7PCKA 4OELA 3C9EA 5JH3A 1GCBA 3PT2A 4XR7A 1BY8A 1K3BB 2GHUA 3IFUA 1Y08A 1ICFA 3PRPA 1YVBA 4OVZB 4YYQA 3RVVA 3W31A 4BS6A 1NPZA 1F29A 5KO3A 4HWYA 1NL6A 1ITOA 4P6EA 4YYRA 2AYNA 2FT2A 2FTDA 4DMYA 4CZWA 4BOUA 2ARYA 4YYVA 3OF9A 1AU2A 4MSXA 3U8EA 2HD5A 1NQCA 1HUCB 5CVMA 3V6EA 4RY2A 2OZ2A 1PADA 1ATKA 2FUDA 2PNSA 2E02A 4D8BA 3QT4A 2P86A 2FE8A 4I04A 3KWZA 3CBJA 3LFYA 4QBBA 2F1GA 3KWBX 2AS8A 1QDQA 4XUIA 1MS6A 2G6DA 3BWKA 2ACTA 1F2CA 2YJCA 4GUAA 5CVNB 4QH6A 4K7CA 4WURA 4CDFB 1X9YA 1ME3A 3H8BA 4G54A 2UZJA 3PHWA 3O0UA 5CVOB 3ZNHA 1PXVA 2JTCA 1AYUA 1ZIVA 3NHEA 4BSQA 1AU0A 3P5VA 3IV2A 4N8WA 2HWKA 2H7JA 4N79A 1BQIA 2DCAA 5K16A 2DCCA 2FQ9A 4A5UA 3TMPA 3V6CA 4FJCA 1AU3A 1MHWA 1THEA 3KW9A 1AYVA 4PADA 5JZEA 3PNRA 2VHFA 4PT5A 1IWDA 2FYEA 1KFUL 2OULA 3B79A 4R3DA 2DJFB 4HXDB 3IUTA 1FH0A 2BU3A 2P0RA 3CBKA 2YJ2A 4PP2E 1PCIA 2R9MA 3GCBA 3D6SA 1EWPA 4RKXA 2AUZA 3OVXA 4X6IA 2AU1A 3KFQA 2J7QC 1PE6A 3H8CA 1SNKA 4RF0A 1PIPA 2IBIA 2P7UA 1CQDA 5CHVA 3O65A 4BOSA 2BDLA 4RF1A 1EWMA 2CIOA 3MORA 3PRMA 3OISA 4Q8GA 4Q8HA 1GECE 2Y5BA 3PSEA 4BOQA 5PADA 1BGOA 1ME4A 8PCHA 4QRGA 1KHQA 2R9CA 1GMYA 4PP1A 3P5XA 1EWLA 1U9QX 1PPPA 3F5VA 1F2BA 4FK5A 4OEMA 3PW3A 1TLOA 1SP4B 1CVZA 2OP3A 2DJGB 3MHSA 1MDWA 2XU4A 2XU5A 1CPJA 1KFXL 2AUXA 4D8IA 4CDEB 1STFE 1MEMA 4AXLA 1BP4A 3K9MA 2BDZA 2VHSA 2WBFX 1TU6A 2HHNA 3BCNA 3ZUAA 3BC3A 3PBHA 1ZCMA 3BPMA 3P5WA 1QXPA 3H6SA 1JQPA 5J94A 4DMXA 3C0RA 5F02A 2G8EA 2DZYA 2F7DA 4MM3B 4I05A 1UKFA 4QRVA 3TNXA 2PBHA 2R6NA 3CH3X 3W30A 1XKGA 1MIRA 2FRQA 1YK8A 4OW0A 3I3TA 4YYWA 4XZXA 1U9WA 2O6XA 3IMAA 1Y4HA 5EGWA 1PPNA 1NB5A 1EWOA 3B21A 4ZTBA 3OQCA 4W5CA 3DF0A 1KHPA 4CDDB 2R9NA 3PHXA 3IEJA 3BB7A 1YALA 4WA6A 4BS5A 2DC6A 4P6GA 1PBHA 2XU1A 3IOQA 3HD3A 3BOWA 1EF7A 2IPPB 2R9FA 1CB5A 3KSEA 2Y6EA 3BBAA 5A24A 1YZBA 2JQGR 4MI7A 3MHHA 3WXGA 4W5BA 1AECA 2E00A 3WXEA 4X6JA 2B1MA 3ERVA 1M6DA 2DC9A 3E1ZB 2XU3A 2DCBA 2AIMA 1A6RA 1AYWA 2BTWA 2E01A 1YT7A 3TRKA 1PVJA 3H89A 1KXRA 4I07A 2YJ8A 3KX1A 2AYOA 2AVWA 3QJ3A 1CSBB 1DEUA 3HHIA 3CH2X 2JQFR 1POPA 3IHPA 3OVZA 4KLBA 4IP3A 2CB5A 2YJBA 3BY4A 4BOZA 2DOSA 3K24A 4AXMA 3K8UA 3O1GA 4YYSA 5EZQA 4MZOA 2NQDB 1DKIA 3MJ5A 3H7DA 3PDFA 3P5UA 4CDCB
chains in the Genus database with same CATH topology
2BU3A 3IFUA 4OW0A 4M0WA 3PRPA 4XZXA 4OVZB 3W31A 4RKXA 2JRIA 5KO3A 4RNAA 4REZA 3B21A 2J7QC 2AGAA 4ZTBA 3OQCA 2BTWB 4RF0A 4BOUA 3O65A 4D8EA 3PHXA 3BB7A 4BOSA 3PHUA 4RF1A 3PRMA 2J7QA 4D8BA 4BOQA 3PSEA 5E6JA 2FE8A 3BBAA 2Z84A 1YZBA 4MI7A 4OVZA 5EZSA 4GUAA 4WURA 3E9SA 2BTWA 2UZJA 3TRKA 3PHWA 1PVJA 3MP2A 3ZNHA 4D8IA 2JTCA 3RNVA 4IUMA 2HWKA 4P16A 4A5UA 3TMPA 5JZEA 3C0RA 4IP3A 4PT5A 3BY4A 4BOZA 2DOSA 4MM3B 4BOPA 1UKFA 3MTVA 4R3DA 4HXDB 5EZQA 1DKIA 3MJ5A 3W30A 3PT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  2UZJ A;  2JTC A;  3BB7 A;  4D8B A;  4RKX A;  3BBA A;  1DKI A;  1PVJ A;  4D8E A; 
#chains in the Genus database with same CATH topology
 1U9X A;  1CTE A;  4M0W A;  1NLJ A;  4BPV A;  5JA7 A;  4X6H A;  4ZUX U;  1VJV A;  1QOL A;  2JRI A;  1YK7 A;  2GFO A;  4RNA A;  4REZ A;  1CS8 A;  9PAP A;  4QRX A;  5FPW A;  4N4Z A;  2AGA A;  6PAD A;  2BTW B;  2DC7 A;  3AI8 A;  3N3G A;  2PRE A;  2G7Y A;  2PAD A;  4D8E A;  1AIM A;  3I06 A;  3PHU A;  1MEG A;  1AU4 A;  1F2A A;  4YVA A;  2J7Q A;  2NQG A;  1PPD A;  3MTN A;  5E6J A;  3M99 A;  3S3Q A;  4FIP A;  2ATO A;  1NB3 A;  2FRA A;  4PI3 A;  2Z84 A;  4YYU A;  1U5I A;  1QMY A;  3BPF A;  2DZZ A;  4OVZ A;  2HH5 A;  5EZS A;  1U9V A;  1S4V A;  2DC8 A;  3F75 A;  2DCD A;  3N4C A;  2E03 A;  3USV A;  3HHA A;  3E9S A;  5EF4 A;  5CHT A;  1Q6K A;  1CJL A;  4MZS A;  4YV8 A;  3WXF A;  3MP2 A;  4BQV A;  3RNV A;  3RVX A;  3RVW A;  2NQI A;  4IUM A;  1TL9 A;  3OF8 A;  1VSN A;  3N3K A;  1O0E A;  2NQA A;  2G8J A;  3QSD A;  1DF0 A;  3KKU A;  4P16 A;  1GLO A;  1CV8 A;  1PPO A;  2C0Y A;  2R9O A;  2FO5 A;  3S3R A;  2HXZ A;  3HWN A;  4BOP A;  4W4U A;  2B1N A;  3MTV A;  3LXS A;  2YJ9 A;  7PCK A;  4OEL A;  3C9E A;  5JH3 A;  1GCB A;  3PT2 A;  4XR7 A;  1BY8 A;  1K3B B;  2GHU A;  3IFU A;  1Y08 A;  1ICF A;  3PRP A;  1YVB A;  4OVZ B;  4YYQ A;  3RVV A;  3W31 A;  4BS6 A;  1NPZ A;  1F29 A;  5KO3 A;  4HWY A;  1NL6 A;  1ITO A;  4P6E A;  4YYR A;  2AYN A;  2FT2 A;  2FTD A;  4DMY A;  4CZW A;  4BOU A;  2ARY A;  4YYV A;  3OF9 A;  1AU2 A;  4MSX A;  3U8E A;  2HD5 A;  1NQC A;  1HUC B;  5CVM A;  3V6E A;  4RY2 A;  2OZ2 A;  1PAD A;  1ATK A;  2FUD A;  2PNS A;  2E02 A;  4D8B A;  3QT4 A;  2P86 A;  2FE8 A;  4I04 A;  3KWZ A;  3CBJ A;  3LFY A;  4QBB A;  2F1G A;  3KWB X;  2AS8 A;  1QDQ A;  4XUI A;  1MS6 A;  2G6D A;  3BWK A;  2ACT A;  1F2C A;  2YJC A;  4GUA A;  5CVN B;  4QH6 A;  4K7C A;  4WUR A;  4CDF B;  1X9Y A;  1ME3 A;  3H8B A;  4G54 A;  2UZJ A;  3PHW A;  3O0U A;  5CVO B;  3ZNH A;  1PXV A;  2JTC A;  1AYU A;  1ZIV A;  3NHE A;  4BSQ A;  1AU0 A;  3P5V A;  3IV2 A;  4N8W A;  2HWK A;  2H7J A;  4N79 A;  1BQI A;  2DCA A;  5K16 A;  2DCC A;  2FQ9 A;  4A5U A;  3TMP A;  3V6C A;  4FJC A;  1AU3 A;  1MHW A;  1THE A;  3KW9 A;  1AYV A;  4PAD A;  5JZE A;  3PNR A;  2VHF A;  4PT5 A;  1IWD A;  2FYE A;  1KFU L;  2OUL A;  3B79 A;  4R3D A;  2DJF B;  4HXD B;  3IUT A;  1FH0 A;  2BU3 A;  2P0R A;  3CBK A;  2YJ2 A;  4PP2 E;  1PCI A;  2R9M A;  3GCB A;  3D6S A;  1EWP A;  4RKX A;  2AUZ A;  3OVX A;  4X6I A;  2AU1 A;  3KFQ A;  2J7Q C;  1PE6 A;  3H8C A;  1SNK A;  4RF0 A;  1PIP A;  2IBI A;  2P7U A;  1CQD A;  5CHV A;  3O65 A;  4BOS A;  2BDL A;  4RF1 A;  1EWM A;  2CIO A;  3MOR A;  3PRM A;  3OIS A;  4Q8G A;  4Q8H A;  1GEC E;  2Y5B A;  3PSE A;  4BOQ A;  5PAD A;  1BGO A;  1ME4 A;  8PCH A;  4QRG A;  1KHQ A;  2R9C A;  1GMY A;  4PP1 A;  3P5X A;  1EWL A;  1U9Q X;  1PPP A;  3F5V A;  1F2B A;  4FK5 A;  4OEM A;  3PW3 A;  1TLO A;  1SP4 B;  1CVZ A;  2OP3 A;  2DJG B;  3MHS A;  1MDW A;  2XU4 A;  2XU5 A;  1CPJ A;  1KFX L;  2AUX A;  4D8I A;  4CDE B;  1STF E;  1MEM A;  4AXL A;  1BP4 A;  3K9M A;  2BDZ A;  2VHS A;  2WBF X;  1TU6 A;  2HHN A;  3BCN A;  3ZUA A;  3BC3 A;  3PBH A;  1ZCM A;  3BPM A;  3P5W A;  1QXP A;  3H6S A;  1JQP A;  5J94 A;  4DMX A;  3C0R A;  5F02 A;  2G8E A;  2DZY A;  2F7D A;  4MM3 B;  4I05 A;  1UKF A;  4QRV A;  3TNX A;  2PBH A;  2R6N A;  3CH3 X;  3W30 A;  1XKG A;  1MIR A;  2FRQ A;  1YK8 A;  4OW0 A;  3I3T A;  4YYW A;  4XZX A;  1U9W A;  2O6X A;  3IMA A;  1Y4H A;  5EGW A;  1PPN A;  1NB5 A;  1EWO A;  3B21 A;  4ZTB A;  3OQC A;  4W5C A;  3DF0 A;  1KHP A;  4CDD B;  2R9N A;  3PHX A;  3IEJ A;  3BB7 A;  1YAL A;  4WA6 A;  4BS5 A;  2DC6 A;  4P6G A;  1PBH A;  2XU1 A;  3IOQ A;  3HD3 A;  3BOW A;  1EF7 A;  2IPP B;  2R9F A;  1CB5 A;  3KSE A;  2Y6E A;  3BBA A;  5A24 A;  1YZB A;  2JQG R;  4MI7 A;  3MHH A;  3WXG A;  4W5B A;  1AEC A;  2E00 A;  3WXE A;  4X6J A;  2B1M A;  3ERV A;  1M6D A;  2DC9 A;  3E1Z B;  2XU3 A;  2DCB A;  2AIM A;  1A6R A;  1AYW A;  2BTW A;  2E01 A;  1YT7 A;  3TRK A;  1PVJ A;  3H89 A;  1KXR A;  4I07 A;  2YJ8 A;  3KX1 A;  2AYO A;  2AVW A;  3QJ3 A;  1CSB B;  1DEU A;  3HHI A;  3CH2 X;  2JQF R;  1POP A;  3IHP A;  3OVZ A;  4KLB A;  4IP3 A;  2CB5 A;  2YJB A;  3BY4 A;  4BOZ A;  2DOS A;  3K24 A;  4AXM A;  3K8U A;  3O1G A;  4YYS A;  5EZQ A;  4MZO A;  2NQD B;  1DKI A;  3MJ5 A;  3H7D A;  3PDF A;  3P5U A;  4CDC B; 
#chains in the Genus database with same CATH homology
 2BU3 A;  3IFU A;  4OW0 A;  4M0W A;  3PRP A;  4XZX A;  4OVZ B;  3W31 A;  4RKX A;  2JRI A;  5KO3 A;  4RNA A;  4REZ A;  3B21 A;  2J7Q C;  2AGA A;  4ZTB A;  3OQC A;  2BTW B;  4RF0 A;  4BOU A;  3O65 A;  4D8E A;  3PHX A;  3BB7 A;  4BOS A;  3PHU A;  4RF1 A;  3PRM A;  2J7Q A;  4D8B A;  4BOQ A;  3PSE A;  5E6J A;  2FE8 A;  3BBA A;  2Z84 A;  1YZB A;  4MI7 A;  4OVZ A;  5EZS A;  4GUA A;  4WUR A;  3E9S A;  2BTW A;  2UZJ A;  3TRK A;  3PHW A;  1PVJ A;  3MP2 A;  3ZNH A;  4D8I A;  2JTC A;  3RNV A;  4IUM A;  2HWK A;  4P16 A;  4A5U A;  3TMP A;  5JZE A;  3C0R A;  4IP3 A;  4PT5 A;  3BY4 A;  4BOZ A;  2DOS A;  4MM3 B;  4BOP A;  1UKF A;  3MTV A;  4R3D A;  4HXD B;  5EZQ A;  1DKI A;  3MJ5 A;  3W30 A;  3PT2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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