4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
b'QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
molecule keywords Streptopain
source organism Streptococcus pyogenes
molecule tags Hydrolase/hydrolase inhibitor
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
1PVJA 3BB7A 4D8BA 4RKXA 4D8EA 3BBAA 2UZJA 1DKIA 4D8IA 2JTCA
chains in the Genus database with same CATH superfamily
4MM3B 4M0WA 1BP4A 3USVA 3PW3A 2HHNA 4QH6A 3DF0A 1NLJA 4R3DA 1AIMA 3IMAA 3LXSA 3KSEA 3MTNA 1SP4B 2PBHA 1HUCB 1A6RA 4X6HA 4MSXA 1NL6A 4IP3A 3PNRA 1GECE 3PHWA 3W30A 2DZZA 3HD3A 1PIPA 2BTWB 2HH5A 3TRKA 2J7QA 3PSEA 1QDQA 4QBBA 1GCBA 4PT5A 2GHUA 4BOUA 1EF7A 1KFUL 3O0UA 3NHEA 2DOSA 2NQGA 4QRVA 3U8EA 3D6SA 4YYVA 2VHSA 3IOQA 3MHHA 1CV8A 4I07A 4BQVA 6PADA 1FH0A 2DC8A 3RVWA 1XKGA 1CPJA 2FUDA 4YYQA 2E00A 2YJ9A 1M6DA 4FK5A 2CB5A 3BBAA 5CHTA 3V6CA 4BOSA 5KO3A 4BS6A 1KFXL 4OVZA 4PI3A 4CDCB 3KX1A 1BGOA 7PCKA 5F02A 4BOQA 1VJVA 3B21A 4HXDB 1TL9A 3M99A 4WURA 4PP2E 1ZCMA 2FYEA 4P6GA 1ITOA 2AUZA 5JZEA 1NPZA 2P86A 1PXVA 2FQ9A 4D8IA 1F2AA 1YK7A 4YVAA 1TLOA 1U9VA 4IUMA 2B1MA 3BWKA 1MEMA 1CS8A 3PT2A 3F75A 4Q8GA 2VHFA 1QXPA 1DKIA 5CVMA 3CH2X 2AYNA 1THEA 2XU4A 1GMYA 2G8JA 1U9XA 3ERVA 3K24A 1EWMA 3H7DA 4CDDB 1AECA 1PVJA 3OF8A 4XZXA 2E02A 4QRXA 4XR7A 3TNXA 4CDEB 4HWYA 3KWZA 2F1GA 4YYWA 2YJ2A 1AYUA 3MP2A 1AU3A 3QSDA 2OZ2A 1NB5A 1ME3A 2E03A 1PADA 1PBHA 8PCHA 3TMPA 2PADA 4WA6A 2R9CA 3BOWA 4GUAA 4MZSA 3MHSA 1NQCA 4N4ZA 2JRIA 2B1NA 1X9YA 3RNVA 4A5UA 1CVZA 2P7UA 2O6XA 2G6DA 1EWLA 1QOLA 3AI8A 3PRMA 2XU1A 1MHWA 4I04A 1YVBA 4ZTBA 2DCDA 2DCCA 4KLBA 3P5XA 5CHVA 3B79A 3MTVA 1YK8A 4K7CA 5CVNB 1CQDA 3OQCA 2C0YA 4MI7A 5J94A 1NB3A 3PHUA 3BY4A 1U5IA 2YJ8A 3F5VA 5EZQA 5K16A 5PADA 1ATKA 1KHPA 2AUXA 2HWKA 2XU5A 5EZSA 2BU3A 2J7QC 2DCAA 3P5UA 3BCNA 1AU0A 4XUIA 3OF9A 3KFQA 1ME4A 3KWBX 1YZBA 4RF0A 3CBJA 2AGAA 3BPMA 1POPA 3OVXA 2BTWA 4RY2A 2R6NA 4CZWA 4REZA 4BPVA 3ZNHA 2OP3A 1F2BA 4DMYA 1S4VA 3H8BA 3RVXA 2DCBA 4N79A 5JA7A 2JTCA 1PPPA 3N3GA 3HHIA 3E1ZB 4OEMA 4QRGA 2AYOA 3C9EA 2AVWA 2H7JA 4PADA 4RNAA 3PHXA 1KHQA 1SNKA 1PCIA 1CJLA 3K8UA 2PNSA 4X6IA 5EGWA 1CB5A 3S3QA 2Y6EA 3P5VA 2YJCA 1AU2A 4AXLA 2NQIA 2PREA 4CDFB 1IWDA 4YYRA 3W31A 1AYWA 2XU3A 3IEJA 4Q8HA 3O65A 1AU4A 3P5WA 3LFYA 2DC7A 2DJGB 3I3TA 4MZOA 2G7YA 3IHPA 1YT7A 4FJCA 5CVOB 1VSNA 2R9OA 2FTDA 2NQDB 3H89A 3BB7A 3PDFA 3CBKA 2Y5BA 3BC3A 2ACTA 1EWOA 3WXEA 3PBHA 3O1GA 3C0RA 4W5CA 4AXMA 4D8EA 5A24A 2AIMA 4OVZB 2AS8A 2FRAA 4PP1A 1DEUA 2DZYA 2R9MA 3N3KA 4YV8A 4BS5A 3S3RA 4BSQA 1STFE 3N4CA 5EF4A 3KKUA 4W4UA 2JQFR 3GCBA 3OVZA 2FT2A 5E6JA 5JH3A 4P16A 2ATOA 1ICFA 1EWPA 2HD5A 4YYSA 3MJ5A 3RVVA 3CH3X 2G8EA 1PPOA 1O0EA 1DF0A 2YJBA 4OELA 3KW9A 2FRQA 1KXRA 4BOPA 2WBFX 2R9NA 3V6EA 3H8CA 2AU1A 4YYUA 9PAPA 1CSBB 3IUTA 4W5BA 5FPWA 1JQPA 3ZUAA 2CIOA 2GFOA 3I06A 2JQGR 4DMXA 2BDLA 1UKFA 4D8BA 3E9SA 1K3BB 4G54A 4I05A 2IPPB 1PPDA 3BPFA 1YALA 2F7DA 1QMYA 2BDZA 1PPNA 3H6SA 1GLOA 1F29A 1CTEA 2E01A 1BY8A 1F2CA 2DC9A 3HHAA 3OISA 1Q6KA 2ARYA 2UZJA 3MORA 4X6JA 2Z84A 3HWNA 3WXFA 4OW0A 1MEGA 3QT4A 1Y08A 4N8WA 2FE8A 3QJ3A 3K9MA 1TU6A 1BQIA 1PE6A 3PRPA 4ZUXU 1ZIVA 2IBIA 1U9WA 4P6EA 2R9FA 4RKXA 1MS6A 3WXGA 3IV2A 4RF1A 2DJFB 2HXZA 4BOZA 1MIRA 1Y4HA 2NQAA 2OULA 1AYVA 4FIPA 1U9QX 3IFUA 2DC6A 2P0RA 1MDWA 2FO5A
chains in the Genus database with same CATH topology
4MM3B 1PVJA 2BTWA 4M0WA 4XZXA 4REZA 3ZNHA 4R3DA 4BOPA 3MP2A 2JTCA 4IP3A 3PHWA 3W30A 2BTWB 3TMPA 3TRKA 2J7QA 4RNAA 3PSEA 3PHXA 4BOUA 4PT5A 4GUAA 1UKFA 4D8BA 2DOSA 3E9SA 2JRIA 3RNVA 4A5UA 3W31A 3BBAA 3O65A 4BOSA 5KO3A 3PRMA 4OVZA 2UZJA 4ZTBA 4BOQA 3B21A 2Z84A 4HXDB 4OW0A 3BB7A 3MTVA 2FE8A 4WURA 3OQCA 4MI7A 5JZEA 3C0RA 3PHUA 4D8EA 3BY4A 4D8IA 3PRPA 4OVZB 4IUMA 5EZQA 4RKXA 3PT2A 4RF1A 2HWKA 1DKIA 2BU3A 2J7QC 5EZSA 4BOZA 5E6JA 4RF0A 4P16A 1YZBA 3IFUA 2AGAA 3MJ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PVJ A;  3BB7 A;  4D8B A;  4RKX A;  4D8E A;  3BBA A;  2UZJ A;  1DKI A;  4D8I A;  2JTC A; 
#chains in the Genus database with same CATH topology
 4MM3 B;  4M0W A;  1BP4 A;  3USV A;  3PW3 A;  2HHN A;  4QH6 A;  3DF0 A;  1NLJ A;  4R3D A;  1AIM A;  3IMA A;  3LXS A;  3KSE A;  3MTN A;  1SP4 B;  2PBH A;  1HUC B;  1A6R A;  4X6H A;  4MSX A;  1NL6 A;  4IP3 A;  3PNR A;  1GEC E;  3PHW A;  3W30 A;  2DZZ A;  3HD3 A;  1PIP A;  2BTW B;  2HH5 A;  3TRK A;  2J7Q A;  3PSE A;  1QDQ A;  4QBB A;  1GCB A;  4PT5 A;  2GHU A;  4BOU A;  1EF7 A;  1KFU L;  3O0U A;  3NHE A;  2DOS A;  2NQG A;  4QRV A;  3U8E A;  3D6S A;  4YYV A;  2VHS A;  3IOQ A;  3MHH A;  1CV8 A;  4I07 A;  4BQV A;  6PAD A;  1FH0 A;  2DC8 A;  3RVW A;  1XKG A;  1CPJ A;  2FUD A;  4YYQ A;  2E00 A;  2YJ9 A;  1M6D A;  4FK5 A;  2CB5 A;  3BBA A;  5CHT A;  3V6C A;  4BOS A;  5KO3 A;  4BS6 A;  1KFX L;  4OVZ A;  4PI3 A;  4CDC B;  3KX1 A;  1BGO A;  7PCK A;  5F02 A;  4BOQ A;  1VJV A;  3B21 A;  4HXD B;  1TL9 A;  3M99 A;  4WUR A;  4PP2 E;  1ZCM A;  2FYE A;  4P6G A;  1ITO A;  2AUZ A;  5JZE A;  1NPZ A;  2P86 A;  1PXV A;  2FQ9 A;  4D8I A;  1F2A A;  1YK7 A;  4YVA A;  1TLO A;  1U9V A;  4IUM A;  2B1M A;  3BWK A;  1MEM A;  1CS8 A;  3PT2 A;  3F75 A;  4Q8G A;  2VHF A;  1QXP A;  1DKI A;  5CVM A;  3CH2 X;  2AYN A;  1THE A;  2XU4 A;  1GMY A;  2G8J A;  1U9X A;  3ERV A;  3K24 A;  1EWM A;  3H7D A;  4CDD B;  1AEC A;  1PVJ A;  3OF8 A;  4XZX A;  2E02 A;  4QRX A;  4XR7 A;  3TNX A;  4CDE B;  4HWY A;  3KWZ A;  2F1G A;  4YYW A;  2YJ2 A;  1AYU A;  3MP2 A;  1AU3 A;  3QSD A;  2OZ2 A;  1NB5 A;  1ME3 A;  2E03 A;  1PAD A;  1PBH A;  8PCH A;  3TMP A;  2PAD A;  4WA6 A;  2R9C A;  3BOW A;  4GUA A;  4MZS A;  3MHS A;  1NQC A;  4N4Z A;  2JRI A;  2B1N A;  1X9Y A;  3RNV A;  4A5U A;  1CVZ A;  2P7U A;  2O6X A;  2G6D A;  1EWL A;  1QOL A;  3AI8 A;  3PRM A;  2XU1 A;  1MHW A;  4I04 A;  1YVB A;  4ZTB A;  2DCD A;  2DCC A;  4KLB A;  3P5X A;  5CHV A;  3B79 A;  3MTV A;  1YK8 A;  4K7C A;  5CVN B;  1CQD A;  3OQC A;  2C0Y A;  4MI7 A;  5J94 A;  1NB3 A;  3PHU A;  3BY4 A;  1U5I A;  2YJ8 A;  3F5V A;  5EZQ A;  5K16 A;  5PAD A;  1ATK A;  1KHP A;  2AUX A;  2HWK A;  2XU5 A;  5EZS A;  2BU3 A;  2J7Q C;  2DCA A;  3P5U A;  3BCN A;  1AU0 A;  4XUI A;  3OF9 A;  3KFQ A;  1ME4 A;  3KWB X;  1YZB A;  4RF0 A;  3CBJ A;  2AGA A;  3BPM A;  1POP A;  3OVX A;  2BTW A;  4RY2 A;  2R6N A;  4CZW A;  4REZ A;  4BPV A;  3ZNH A;  2OP3 A;  1F2B A;  4DMY A;  1S4V A;  3H8B A;  3RVX A;  2DCB A;  4N79 A;  5JA7 A;  2JTC A;  1PPP A;  3N3G A;  3HHI A;  3E1Z B;  4OEM A;  4QRG A;  2AYO A;  3C9E A;  2AVW A;  2H7J A;  4PAD A;  4RNA A;  3PHX A;  1KHQ A;  1SNK A;  1PCI A;  1CJL A;  3K8U A;  2PNS A;  4X6I A;  5EGW A;  1CB5 A;  3S3Q A;  2Y6E A;  3P5V A;  2YJC A;  1AU2 A;  4AXL A;  2NQI A;  2PRE A;  4CDF B;  1IWD A;  4YYR A;  3W31 A;  1AYW A;  2XU3 A;  3IEJ A;  4Q8H A;  3O65 A;  1AU4 A;  3P5W A;  3LFY A;  2DC7 A;  2DJG B;  3I3T A;  4MZO A;  2G7Y A;  3IHP A;  1YT7 A;  4FJC A;  5CVO B;  1VSN A;  2R9O A;  2FTD A;  2NQD B;  3H89 A;  3BB7 A;  3PDF A;  3CBK A;  2Y5B A;  3BC3 A;  2ACT A;  1EWO A;  3WXE A;  3PBH A;  3O1G A;  3C0R A;  4W5C A;  4AXM A;  4D8E A;  5A24 A;  2AIM A;  4OVZ B;  2AS8 A;  2FRA A;  4PP1 A;  1DEU A;  2DZY A;  2R9M A;  3N3K A;  4YV8 A;  4BS5 A;  3S3R A;  4BSQ A;  1STF E;  3N4C A;  5EF4 A;  3KKU A;  4W4U A;  2JQF R;  3GCB A;  3OVZ A;  2FT2 A;  5E6J A;  5JH3 A;  4P16 A;  2ATO A;  1ICF A;  1EWP A;  2HD5 A;  4YYS A;  3MJ5 A;  3RVV A;  3CH3 X;  2G8E A;  1PPO A;  1O0E A;  1DF0 A;  2YJB A;  4OEL A;  3KW9 A;  2FRQ A;  1KXR A;  4BOP A;  2WBF X;  2R9N A;  3V6E A;  3H8C A;  2AU1 A;  4YYU A;  9PAP A;  1CSB B;  3IUT A;  4W5B A;  5FPW A;  1JQP A;  3ZUA A;  2CIO A;  2GFO A;  3I06 A;  2JQG R;  4DMX A;  2BDL A;  1UKF A;  4D8B A;  3E9S A;  1K3B B;  4G54 A;  4I05 A;  2IPP B;  1PPD A;  3BPF A;  1YAL A;  2F7D A;  1QMY A;  2BDZ A;  1PPN A;  3H6S A;  1GLO A;  1F29 A;  1CTE A;  2E01 A;  1BY8 A;  1F2C A;  2DC9 A;  3HHA A;  3OIS A;  1Q6K A;  2ARY A;  2UZJ A;  3MOR A;  4X6J A;  2Z84 A;  3HWN A;  3WXF A;  4OW0 A;  1MEG A;  3QT4 A;  1Y08 A;  4N8W A;  2FE8 A;  3QJ3 A;  3K9M A;  1TU6 A;  1BQI A;  1PE6 A;  3PRP A;  4ZUX U;  1ZIV A;  2IBI A;  1U9W A;  4P6E A;  2R9F A;  4RKX A;  1MS6 A;  3WXG A;  3IV2 A;  4RF1 A;  2DJF B;  2HXZ A;  4BOZ A;  1MIR A;  1Y4H A;  2NQA A;  2OUL A;  1AYV A;  4FIP A;  1U9Q X;  3IFU A;  2DC6 A;  2P0R A;  1MDW A;  2FO5 A; 
#chains in the Genus database with same CATH homology
 4MM3 B;  1PVJ A;  2BTW A;  4M0W A;  4XZX A;  4REZ A;  3ZNH A;  4R3D A;  4BOP A;  3MP2 A;  2JTC A;  4IP3 A;  3PHW A;  3W30 A;  2BTW B;  3TMP A;  3TRK A;  2J7Q A;  4RNA A;  3PSE A;  3PHX A;  4BOU A;  4PT5 A;  4GUA A;  1UKF A;  4D8B A;  2DOS A;  3E9S A;  2JRI A;  3RNV A;  4A5U A;  3W31 A;  3BBA A;  3O65 A;  4BOS A;  5KO3 A;  3PRM A;  4OVZ A;  2UZJ A;  4ZTB A;  4BOQ A;  3B21 A;  2Z84 A;  4HXD B;  4OW0 A;  3BB7 A;  3MTV A;  2FE8 A;  4WUR A;  3OQC A;  4MI7 A;  5JZE A;  3C0R A;  3PHU A;  4D8E A;  3BY4 A;  4D8I A;  3PRP A;  4OVZ B;  4IUM A;  5EZQ A;  4RKX A;  3PT2 A;  4RF1 A;  2HWK A;  1DKI A;  2BU3 A;  2J7Q C;  5EZS A;  4BOZ A;  5E6J A;  4RF0 A;  4P16 A;  1YZB A;  3IFU A;  2AGA A;  3MJ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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