4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Streptopain
publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase/hydrolase inhibitor
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
2UZJA 4D8BA 4D8IA 1PVJA 3BBAA 3BB7A 4RKXA 4D8EA 2JTCA 1DKIA
chains in the Genus database with same CATH superfamily
3OVXA 2OP3A 2P0RA 3OF8A 3IHPA 3P5UA 3DF0A 4OW0A 4CDCB 4ZUXU 3KKUA 3V6EA 2Z84A 1AECA 3PT2A 1SNKA 4W5CA 3H89A 4OVZB 4ZTBA 4PP2E 2E01A 2AYNA 4IUMA 1AU4A 2R9MA 4K7CA 1JQPA 2UZJA 4RF1A 1PADA 2DC9A 3IOQA 2XU4A 2AUZA 2FE8A 4HWYA 4YYUA 2DC6A 2HXZA 4BOQA 4MZOA 3E9SA 1YK7A 9PAPA 1MHWA 1DKIA 3MTNA 3TNXA 5E6JA 1XKGA 1KFXL 4HXDB 3PHXA 4XUIA 2ATOA 4YYWA 2HD5A 2J7QA 4W5BA 1Q6KA 1F29A 4FK5A 2P86A 1MDWA 2JRIA 4Q8GA 1PPOA 3CH2X 2FRAA 3RVVA 3MP2A 2JQFR 2DJGB 1AYWA 1ATKA 1DEUA 3H8CA 4MSXA 1PPPA 1VSNA 2DC8A 2OZ2A 2ARYA 3QT4A 2R9NA 3H8BA 3PRMA 1YT7A 5JA7A 2AIMA 2AUXA 2PBHA 1U5IA 3KWBX 1FH0A 3BPMA 1CSBB 4MZSA 4X6IA 2DC7A 1EF7A 4AXMA 3WXGA 2R6NA 3MHSA 5FPWA 1K3BB 1PPDA 2XU3A 3K24A 1PPNA 1TL9A 1KHPA 1PBHA 4N4ZA 2HH5A 4QRVA 2DZYA 3H7DA 3PHUA 3ZNHA 5K16A 3CBKA 2DCDA 4PI3A 1AYUA 3RNVA 2DOSA 5JZEA 3GCBA 1KXRA 1F2BA 8PCHA 4XZXA 3HWNA 2Y6EA 2YJ8A 2XU1A 2GHUA 1CB5A 3OF9A 4YYRA 1NPZA 2AGAA 1BGOA 4I04A 2NQAA 5F02A 4WURA 1CS8A 2FT2A 2E02A 2BU3A 4BPVA 1YK8A 3KX1A 4CZWA 1U9WA 2BDZA 2NQIA 2PNSA 1DF0A 3TRKA 2JTCA 4OVZA 2BTWA 4WA6A 1KHQA 4YYVA 1NLJA 2GFOA 1CPJA 1ME3A 5PADA 2DZZA 3IMAA 1CQDA 3P5VA 4BS5A 1MEMA 3MJ5A 1QMYA 3B79A 2HHNA 1GLOA 1ZCMA 2B1NA 4RNAA 1EWOA 3MORA 3PRPA 4AXLA 2AS8A 4X6HA 1EWMA 5CVMA 4D8IA 4OELA 3BPFA 1AU3A 4M0WA 1IWDA 1PIPA 3B21A 3O65A 2O6XA 2AVWA 3LFYA 4DMYA 4YVAA 1EWLA 1CV8A 4FIPA 1AYVA 5A24A 4MM3B 5CVOB 1QOLA 3HHAA 2G8EA 2FTDA 3IUTA 2ACTA 3K9MA 4GUAA 3O0UA 2NQDB 4Q8HA 3HHIA 4CDDB 3HD3A 2JQGR 1M6DA 4PP1A 6PADA 2YJBA 2DCBA 5EZSA 4I05A 1VJVA 3BBAA 4D8EA 3BWKA 4G54A 1MS6A 3TMPA 1EWPA 1CVZA 4BOPA 2R9OA 1ME4A 3OVZA 3BCNA 2HWKA 4I07A 5CHVA 4RY2A 3K8UA 3PBHA 3RVWA 3PSEA 3OQCA 4DMXA 4QH6A 4P16A 4YV8A 1PCIA 2FO5A 4QBBA 1S4VA 4CDEB 3M99A 4KLBA 3C9EA 2R9CA 3AI8A 1QXPA 1BQIA 1X9YA 2YJ9A 3W30A 1U9QX 3BOWA 3I3TA 2PREA 4BOUA 3IFUA 3S3RA 3KW9A 4PADA 2G8JA 3KFQA 3IEJA 1AIMA 1F2AA 2FUDA 3IV2A 2F7DA 1CJLA 4X6JA 5KO3A 4QRXA 2FQ9A 4BSQA 4D8BA 5J94A 3OISA 1SP4B 2C0YA 4XR7A 2E00A 3W31A 1GECE 4YYQA 1YZBA 2CIOA 3E1ZB 2FRQA 4P6EA 3KWZA 3N4CA 5JH3A 3MTVA 2YJCA 3PHWA 1NQCA 1TLOA 2FYEA 4N8WA 4A5UA 2Y5BA 3O1GA 1GCBA 5EF4A 1NL6A 1PXVA 2DJFB 4RF0A 2BTWB 7PCKA 3S3QA 2OULA 1THEA 2G7YA 2R9FA 1MEGA 1CTEA 3QSDA 3WXFA 2H7JA 3P5WA 2B1MA 3P5XA 4BQVA 1F2CA 4MI7A 2J7QC 4BOSA 3F5VA 2PADA 3BY4A 1STFE 3LXSA 2IBIA 4YYSA 3BC3A 4OEMA 1GMYA 1AU0A 3N3GA 2AU1A 3F75A 1U9VA 5EZQA 2BDLA 3CH3X 4N79A 4BOZA 3H6SA 1ITOA 2DCAA 1A6RA 1TU6A 1YVBA 4PT5A 3USVA 2E03A 4FJCA 2VHSA 3MHHA 4QRGA 1BY8A 2CB5A 4REZA 1NB5A 3N3KA 4RKXA 5CVNB 3ERVA 3RVXA 5CHTA 2NQGA 1POPA 1HUCB 1MIRA 2VHFA 2YJ2A 3WXEA 3U8EA 2F1GA 3QJ3A 1UKFA 1Y4HA 4IP3A 1U9XA 2AYOA 3BB7A 3NHEA 3KSEA 5EGWA 3ZUAA 4R3DA 1ICFA 4P6GA 3CBJA 4W4UA 1KFUL 2DCCA 3PDFA 3C0RA 3D6SA 2G6DA 3PW3A 3PNRA 1NB3A 1QDQA 3V6CA 4CDFB 2P7UA 2XU5A 1AU2A 1PVJA 1YALA 1PE6A 1BP4A 1ZIVA 1O0EA 2WBFX 1Y08A 2IPPB 4BS6A 3I06A
chains in the Genus database with same CATH topology
4OW0A 4MM3B 2Z84A 3PT2A 4MI7A 2J7QC 4BOSA 3BY4A 4OVZB 4ZTBA 4GUAA 5EZSA 3BBAA 3ZNHA 3PHUA 4IUMA 4D8EA 5EZQA 3TMPA 2UZJA 4BOPA 4BOZA 4RF1A 2HWKA 3RNVA 2DOSA 5JZEA 2FE8A 4XZXA 3PSEA 3OQCA 4P16A 4PT5A 2AGAA 4WURA 4BOQA 4REZA 2BU3A 3E9SA 4RKXA 1DKIA 3W30A 5E6JA 4BOUA 3IFUA 4HXDB 3PHXA 3TRKA 2JTCA 4OVZA 2BTWA 2J7QA 5KO3A 1UKFA 4IP3A 4D8BA 2JRIA 3BB7A 3W31A 1YZBA 4R3DA 3MP2A 3MJ5A 4RNAA 3MTVA 3PRPA 3PHWA 3C0RA 4A5UA 3PRMA 4RF0A 4D8IA 1PVJA 2BTWB 4M0WA 3B21A 3O65A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2UZJ A;  4D8B A;  4D8I A;  1PVJ A;  3BBA A;  3BB7 A;  4RKX A;  4D8E A;  2JTC A;  1DKI A; 
#chains in the Genus database with same CATH topology
 3OVX A;  2OP3 A;  2P0R A;  3OF8 A;  3IHP A;  3P5U A;  3DF0 A;  4OW0 A;  4CDC B;  4ZUX U;  3KKU A;  3V6E A;  2Z84 A;  1AEC A;  3PT2 A;  1SNK A;  4W5C A;  3H89 A;  4OVZ B;  4ZTB A;  4PP2 E;  2E01 A;  2AYN A;  4IUM A;  1AU4 A;  2R9M A;  4K7C A;  1JQP A;  2UZJ A;  4RF1 A;  1PAD A;  2DC9 A;  3IOQ A;  2XU4 A;  2AUZ A;  2FE8 A;  4HWY A;  4YYU A;  2DC6 A;  2HXZ A;  4BOQ A;  4MZO A;  3E9S A;  1YK7 A;  9PAP A;  1MHW A;  1DKI A;  3MTN A;  3TNX A;  5E6J A;  1XKG A;  1KFX L;  4HXD B;  3PHX A;  4XUI A;  2ATO A;  4YYW A;  2HD5 A;  2J7Q A;  4W5B A;  1Q6K A;  1F29 A;  4FK5 A;  2P86 A;  1MDW A;  2JRI A;  4Q8G A;  1PPO A;  3CH2 X;  2FRA A;  3RVV A;  3MP2 A;  2JQF R;  2DJG B;  1AYW A;  1ATK A;  1DEU A;  3H8C A;  4MSX A;  1PPP A;  1VSN A;  2DC8 A;  2OZ2 A;  2ARY A;  3QT4 A;  2R9N A;  3H8B A;  3PRM A;  1YT7 A;  5JA7 A;  2AIM A;  2AUX A;  2PBH A;  1U5I A;  3KWB X;  1FH0 A;  3BPM A;  1CSB B;  4MZS A;  4X6I A;  2DC7 A;  1EF7 A;  4AXM A;  3WXG A;  2R6N A;  3MHS A;  5FPW A;  1K3B B;  1PPD A;  2XU3 A;  3K24 A;  1PPN A;  1TL9 A;  1KHP A;  1PBH A;  4N4Z A;  2HH5 A;  4QRV A;  2DZY A;  3H7D A;  3PHU A;  3ZNH A;  5K16 A;  3CBK A;  2DCD A;  4PI3 A;  1AYU A;  3RNV A;  2DOS A;  5JZE A;  3GCB A;  1KXR A;  1F2B A;  8PCH A;  4XZX A;  3HWN A;  2Y6E A;  2YJ8 A;  2XU1 A;  2GHU A;  1CB5 A;  3OF9 A;  4YYR A;  1NPZ A;  2AGA A;  1BGO A;  4I04 A;  2NQA A;  5F02 A;  4WUR A;  1CS8 A;  2FT2 A;  2E02 A;  2BU3 A;  4BPV A;  1YK8 A;  3KX1 A;  4CZW A;  1U9W A;  2BDZ A;  2NQI A;  2PNS A;  1DF0 A;  3TRK A;  2JTC A;  4OVZ A;  2BTW A;  4WA6 A;  1KHQ A;  4YYV A;  1NLJ A;  2GFO A;  1CPJ A;  1ME3 A;  5PAD A;  2DZZ A;  3IMA A;  1CQD A;  3P5V A;  4BS5 A;  1MEM A;  3MJ5 A;  1QMY A;  3B79 A;  2HHN A;  1GLO A;  1ZCM A;  2B1N A;  4RNA A;  1EWO A;  3MOR A;  3PRP A;  4AXL A;  2AS8 A;  4X6H A;  1EWM A;  5CVM A;  4D8I A;  4OEL A;  3BPF A;  1AU3 A;  4M0W A;  1IWD A;  1PIP A;  3B21 A;  3O65 A;  2O6X A;  2AVW A;  3LFY A;  4DMY A;  4YVA A;  1EWL A;  1CV8 A;  4FIP A;  1AYV A;  5A24 A;  4MM3 B;  5CVO B;  1QOL A;  3HHA A;  2G8E A;  2FTD A;  3IUT A;  2ACT A;  3K9M A;  4GUA A;  3O0U A;  2NQD B;  4Q8H A;  3HHI A;  4CDD B;  3HD3 A;  2JQG R;  1M6D A;  4PP1 A;  6PAD A;  2YJB A;  2DCB A;  5EZS A;  4I05 A;  1VJV A;  3BBA A;  4D8E A;  3BWK A;  4G54 A;  1MS6 A;  3TMP A;  1EWP A;  1CVZ A;  4BOP A;  2R9O A;  1ME4 A;  3OVZ A;  3BCN A;  2HWK A;  4I07 A;  5CHV A;  4RY2 A;  3K8U A;  3PBH A;  3RVW A;  3PSE A;  3OQC A;  4DMX A;  4QH6 A;  4P16 A;  4YV8 A;  1PCI A;  2FO5 A;  4QBB A;  1S4V A;  4CDE B;  3M99 A;  4KLB A;  3C9E A;  2R9C A;  3AI8 A;  1QXP A;  1BQI A;  1X9Y A;  2YJ9 A;  3W30 A;  1U9Q X;  3BOW A;  3I3T A;  2PRE A;  4BOU A;  3IFU A;  3S3R A;  3KW9 A;  4PAD A;  2G8J A;  3KFQ A;  3IEJ A;  1AIM A;  1F2A A;  2FUD A;  3IV2 A;  2F7D A;  1CJL A;  4X6J A;  5KO3 A;  4QRX A;  2FQ9 A;  4BSQ A;  4D8B A;  5J94 A;  3OIS A;  1SP4 B;  2C0Y A;  4XR7 A;  2E00 A;  3W31 A;  1GEC E;  4YYQ A;  1YZB A;  2CIO A;  3E1Z B;  2FRQ A;  4P6E A;  3KWZ A;  3N4C A;  5JH3 A;  3MTV A;  2YJC A;  3PHW A;  1NQC A;  1TLO A;  2FYE A;  4N8W A;  4A5U A;  2Y5B A;  3O1G A;  1GCB A;  5EF4 A;  1NL6 A;  1PXV A;  2DJF B;  4RF0 A;  2BTW B;  7PCK A;  3S3Q A;  2OUL A;  1THE A;  2G7Y A;  2R9F A;  1MEG A;  1CTE A;  3QSD A;  3WXF A;  2H7J A;  3P5W A;  2B1M A;  3P5X A;  4BQV A;  1F2C A;  4MI7 A;  2J7Q C;  4BOS A;  3F5V A;  2PAD A;  3BY4 A;  1STF E;  3LXS A;  2IBI A;  4YYS A;  3BC3 A;  4OEM A;  1GMY A;  1AU0 A;  3N3G A;  2AU1 A;  3F75 A;  1U9V A;  5EZQ A;  2BDL A;  3CH3 X;  4N79 A;  4BOZ A;  3H6S A;  1ITO A;  2DCA A;  1A6R A;  1TU6 A;  1YVB A;  4PT5 A;  3USV A;  2E03 A;  4FJC A;  2VHS A;  3MHH A;  4QRG A;  1BY8 A;  2CB5 A;  4REZ A;  1NB5 A;  3N3K A;  4RKX A;  5CVN B;  3ERV A;  3RVX A;  5CHT A;  2NQG A;  1POP A;  1HUC B;  1MIR A;  2VHF A;  2YJ2 A;  3WXE A;  3U8E A;  2F1G A;  3QJ3 A;  1UKF A;  1Y4H A;  4IP3 A;  1U9X A;  2AYO A;  3BB7 A;  3NHE A;  3KSE A;  5EGW A;  3ZUA A;  4R3D A;  1ICF A;  4P6G A;  3CBJ A;  4W4U A;  1KFU L;  2DCC A;  3PDF A;  3C0R A;  3D6S A;  2G6D A;  3PW3 A;  3PNR A;  1NB3 A;  1QDQ A;  3V6C A;  4CDF B;  2P7U A;  2XU5 A;  1AU2 A;  1PVJ A;  1YAL A;  1PE6 A;  1BP4 A;  1ZIV A;  1O0E A;  2WBF X;  1Y08 A;  2IPP B;  4BS6 A;  3I06 A; 
#chains in the Genus database with same CATH homology
 4OW0 A;  4MM3 B;  2Z84 A;  3PT2 A;  4MI7 A;  2J7Q C;  4BOS A;  3BY4 A;  4OVZ B;  4ZTB A;  4GUA A;  5EZS A;  3BBA A;  3ZNH A;  3PHU A;  4IUM A;  4D8E A;  5EZQ A;  3TMP A;  2UZJ A;  4BOP A;  4BOZ A;  4RF1 A;  2HWK A;  3RNV A;  2DOS A;  5JZE A;  2FE8 A;  4XZX A;  3PSE A;  3OQC A;  4P16 A;  4PT5 A;  2AGA A;  4WUR A;  4BOQ A;  4REZ A;  2BU3 A;  3E9S A;  4RKX A;  1DKI A;  3W30 A;  5E6J A;  4BOU A;  3IFU A;  4HXD B;  3PHX A;  3TRK A;  2JTC A;  4OVZ A;  2BTW A;  2J7Q A;  5KO3 A;  1UKF A;  4IP3 A;  4D8B A;  2JRI A;  3BB7 A;  3W31 A;  1YZB A;  4R3D A;  3MP2 A;  3MJ5 A;  4RNA A;  3MTV A;  3PRP A;  3PHW A;  3C0R A;  4A5U A;  3PRM A;  4RF0 A;  4D8I A;  1PVJ A;  2BTW B;  4M0W A;  3B21 A;  3O65 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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