4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
b'QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Streptopain
publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase/hydrolase inhibitor
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
2UZJA 2JTCA 4D8EA 4D8IA 3BB7A 4RKXA 1DKIA 3BBAA 4D8BA 1PVJA
chains in the Genus database with same CATH superfamily
4CDCB 3CH3X 2XU5A 2E00A 3PNRA 2NQIA 1CSBB 2YJCA 2E03A 2JTCA 1KHQA 3BPFA 4RF0A 1KFXL 1AU2A 4YYWA 2AUZA 5EGWA 4IP3A 3B21A 4QRGA 3N4CA 4YYQA 2G7YA 3H89A 2E02A 3GCBA 1PCIA 4X6HA 4OW0A 1F2AA 3QJ3A 3PT2A 4Q8HA 1S4VA 2GFOA 6PADA 1Q6KA 4PT5A 2FTDA 4PP1A 3I3TA 2J7QA 2DCDA 4RY2A 1IWDA 3BC3A 4QH6A 5CHTA 2JRIA 4G54A 2WBFX 1ME4A 1A6RA 1CPJA 2J7QC 4BOPA 2Y6EA 1U5IA 4QRVA 1KFUL 5EZSA 3CBJA 1F29A 1NQCA 3OF9A 1MS6A 3BY4A 4I05A 1PIPA 3TNXA 1TLOA 2G8JA 2G6DA 2UZJA 1YZBA 3MJ5A 3BB7A 5EF4A 4RKXA 2DCBA 1PADA 4PP2E 2XU4A 2G8EA 1QDQA 1XKGA 3S3RA 1HUCB 2BTWA 1CS8A 5JZEA 4MZOA 3K24A 1CJLA 4D8IA 4CDEB 3V6EA 3RNVA 2O6XA 5JH3A 3V6CA 3I06A 1GLOA 2PADA 4W4UA 4X6IA 1AU3A 1MHWA 4RF1A 1PPDA 1EWPA 4PADA 1ZIVA 1F2BA 4MZSA 2BDLA 2JQGR 2OULA 4OEMA 1AYUA 2DZYA 2IBIA 4QBBA 3BOWA 3H7DA 3O0UA 5KO3A 3PHUA 1POPA 3N3KA 1NB3A 4RNAA 2ACTA 1MEGA 3KWBX 3OVXA 3AI8A 1EWLA 3RVXA 2FQ9A 1KXRA 3ZNHA 3RVWA 2H7JA 2YJ8A 4X6JA 2BDZA 4HWYA 4CDFB 4QRXA 3BPMA 1VJVA 3IMAA 2DJGB 4BOUA 5CHVA 1JQPA 3MHHA 1X9YA 5CVMA 1BY8A 1MDWA 3MHSA 2OZ2A 1NPZA 2B1MA 3MORA 3K9MA 3H8BA 3IV2A 4OVZB 3KW9A 3PSEA 3TMPA 3PRMA 3P5XA 1YVBA 1QOLA 2AGAA 2CB5A 1PPPA 1YT7A 2HHNA 4N79A 1AYVA 4IUMA 4MSXA 3WXFA 9PAPA 3OF8A 3KFQA 3PBHA 3BWKA 3D6SA 2DC8A 2HH5A 2R9NA 4Q8GA 2ATOA 2P0RA 1ZCMA 4N8WA 1THEA 4AXMA 2DCCA 1VSNA 3IHPA 1DKIA 2AS8A 8PCHA 3PW3A 3DF0A 2DCAA 2CIOA 2DJFB 2DZZA 1FH0A 4YYVA 2IPPB 2PBHA 1ATKA 2F1GA 1YK8A 1NL6A 3OISA 1STFE 1NB5A 3USVA 3TRKA 2AUXA 2Y5BA 3PHXA 4PI3A 5JA7A 3CBKA 1ME3A 3N3GA 3O1GA 2F7DA 3IEJA 2DC6A 4HXDB 5CVOB 1MIRA 4P6EA 1U9VA 3KSEA 2YJBA 1EF7A 3WXEA 2XU1A 4XZXA 2DC7A 1TU6A 7PCKA 1AECA 1KHPA 4AXLA 1GMYA 2AVWA 2VHFA 5E6JA 2BTWB 4DMYA 2JQFR 1PVJA 3LXSA 3E9SA 4BS5A 3LFYA 2VHSA 3QT4A 3W31A 1Y08A 3ERVA 1PE6A 2P86A 4R3DA 1GCBA 1U9XA 1BGOA 3C9EA 1PXVA 4YV8A 2FRAA 1PPNA 2HXZA 1GECE 1Y4HA 4MM3B 3ZUAA 1U9QX 2AYNA 1PBHA 3M99A 1DEUA 4GUAA 1UKFA 4WURA 1QMYA 3P5UA 4BSQA 2Z84A 1BQIA 1SNKA 5PADA 4BS6A 3PHWA 4FJCA 1DF0A 2FRQA 4D8BA 3P5VA 2R9FA 4WA6A 3RVVA 4MI7A 2DC9A 4I04A 2NQAA 5A24A 1YK7A 2R9MA 3O65A 2PNSA 2YJ2A 5K16A 3OQCA 3MP2A 3HD3A 4KLBA 2R9CA 5EZQA 2GHUA 3NHEA 4CDDB 2NQGA 3CH2X 1O0EA 2FUDA 5J94A 3F75A 3IOQA 1K3BB 2DOSA 2R6NA 3BBAA 4CZWA 3KKUA 4BOQA 2PREA 1CTEA 4YYSA 1QXPA 3KX1A 1F2CA 1NLJA 2AU1A 2OP3A 4A5UA 4BQVA 3MTNA 1SP4B 3F5VA 1AIMA 5FPWA 4K7CA 4W5CA 5CVNB 1YALA 4FIPA 2B1NA 2AYOA 4REZA 4DMXA 3S3QA 4M0WA 1EWMA 2YJ9A 4YVAA 3C0RA 4P16A 3HHIA 3IFUA 2FO5A 4XR7A 3H6SA 1AYWA 4YYUA 2ARYA 1ICFA 2NQDB 3H8CA 1ITOA 2BU3A 3KWZA 3U8EA 1CB5A 4ZUXU 3OVZA 4D8EA 1AU0A 2R9OA 3HHAA 3PDFA 3K8UA 1EWOA 3MTVA 2C0YA 3BCNA 2HD5A 3WXGA 2HWKA 3W30A 4BPVA 3HWNA 4FK5A 4BOZA 2E01A 2FT2A 1CV8A 4P6GA 4XUIA 1AU4A 1BP4A 4N4ZA 4YYRA 2P7UA 1PPOA 4ZTBA 5F02A 3E1ZB 3QSDA 3P5WA 4OELA 4W5BA 1CQDA 3B79A 1MEMA 2AIMA 3IUTA 2XU3A 4I07A 1U9WA 2FYEA 2FE8A 3PRPA 4BOSA 1TL9A 1M6DA 1CVZA 4OVZA
chains in the Genus database with same CATH topology
3OQCA 3MP2A 1DKIA 5EZQA 4RF1A 2JTCA 4RF0A 2DOSA 4IP3A 3B21A 3BBAA 4BOQA 5KO3A 3PHUA 4A5UA 3TRKA 3PHXA 4RNAA 4OW0A 4HXDB 3PT2A 3ZNHA 4REZA 4M0WA 4PT5A 3C0RA 4P16A 2J7QA 3IFUA 4XZXA 2JRIA 4BOUA 2J7QC 4BOPA 5E6JA 2BTWB 2BU3A 5EZSA 1PVJA 3E9SA 4D8EA 3MTVA 3W31A 3BY4A 4R3DA 2HWKA 2UZJA 4OVZB 3W30A 1YZBA 3MJ5A 3PSEA 3BB7A 3TMPA 3PRMA 4RKXA 4BOZA 4MM3B 2AGAA 4GUAA 4IUMA 1UKFA 4WURA 2BTWA 2Z84A 4ZTBA 5JZEA 4D8IA 3PHWA 4D8BA 3RNVA 4MI7A 2FE8A 3PRPA 4BOSA 3O65A 4OVZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2UZJ A;  2JTC A;  4D8E A;  4D8I A;  3BB7 A;  4RKX A;  1DKI A;  3BBA A;  4D8B A;  1PVJ A; 
#chains in the Genus database with same CATH topology
 4CDC B;  3CH3 X;  2XU5 A;  2E00 A;  3PNR A;  2NQI A;  1CSB B;  2YJC A;  2E03 A;  2JTC A;  1KHQ A;  3BPF A;  4RF0 A;  1KFX L;  1AU2 A;  4YYW A;  2AUZ A;  5EGW A;  4IP3 A;  3B21 A;  4QRG A;  3N4C A;  4YYQ A;  2G7Y A;  3H89 A;  2E02 A;  3GCB A;  1PCI A;  4X6H A;  4OW0 A;  1F2A A;  3QJ3 A;  3PT2 A;  4Q8H A;  1S4V A;  2GFO A;  6PAD A;  1Q6K A;  4PT5 A;  2FTD A;  4PP1 A;  3I3T A;  2J7Q A;  2DCD A;  4RY2 A;  1IWD A;  3BC3 A;  4QH6 A;  5CHT A;  2JRI A;  4G54 A;  2WBF X;  1ME4 A;  1A6R A;  1CPJ A;  2J7Q C;  4BOP A;  2Y6E A;  1U5I A;  4QRV A;  1KFU L;  5EZS A;  3CBJ A;  1F29 A;  1NQC A;  3OF9 A;  1MS6 A;  3BY4 A;  4I05 A;  1PIP A;  3TNX A;  1TLO A;  2G8J A;  2G6D A;  2UZJ A;  1YZB A;  3MJ5 A;  3BB7 A;  5EF4 A;  4RKX A;  2DCB A;  1PAD A;  4PP2 E;  2XU4 A;  2G8E A;  1QDQ A;  1XKG A;  3S3R A;  1HUC B;  2BTW A;  1CS8 A;  5JZE A;  4MZO A;  3K24 A;  1CJL A;  4D8I A;  4CDE B;  3V6E A;  3RNV A;  2O6X A;  5JH3 A;  3V6C A;  3I06 A;  1GLO A;  2PAD A;  4W4U A;  4X6I A;  1AU3 A;  1MHW A;  4RF1 A;  1PPD A;  1EWP A;  4PAD A;  1ZIV A;  1F2B A;  4MZS A;  2BDL A;  2JQG R;  2OUL A;  4OEM A;  1AYU A;  2DZY A;  2IBI A;  4QBB A;  3BOW A;  3H7D A;  3O0U A;  5KO3 A;  3PHU A;  1POP A;  3N3K A;  1NB3 A;  4RNA A;  2ACT A;  1MEG A;  3KWB X;  3OVX A;  3AI8 A;  1EWL A;  3RVX A;  2FQ9 A;  1KXR A;  3ZNH A;  3RVW A;  2H7J A;  2YJ8 A;  4X6J A;  2BDZ A;  4HWY A;  4CDF B;  4QRX A;  3BPM A;  1VJV A;  3IMA A;  2DJG B;  4BOU A;  5CHV A;  1JQP A;  3MHH A;  1X9Y A;  5CVM A;  1BY8 A;  1MDW A;  3MHS A;  2OZ2 A;  1NPZ A;  2B1M A;  3MOR A;  3K9M A;  3H8B A;  3IV2 A;  4OVZ B;  3KW9 A;  3PSE A;  3TMP A;  3PRM A;  3P5X A;  1YVB A;  1QOL A;  2AGA A;  2CB5 A;  1PPP A;  1YT7 A;  2HHN A;  4N79 A;  1AYV A;  4IUM A;  4MSX A;  3WXF A;  9PAP A;  3OF8 A;  3KFQ A;  3PBH A;  3BWK A;  3D6S A;  2DC8 A;  2HH5 A;  2R9N A;  4Q8G A;  2ATO A;  2P0R A;  1ZCM A;  4N8W A;  1THE A;  4AXM A;  2DCC A;  1VSN A;  3IHP A;  1DKI A;  2AS8 A;  8PCH A;  3PW3 A;  3DF0 A;  2DCA A;  2CIO A;  2DJF B;  2DZZ A;  1FH0 A;  4YYV A;  2IPP B;  2PBH A;  1ATK A;  2F1G A;  1YK8 A;  1NL6 A;  3OIS A;  1STF E;  1NB5 A;  3USV A;  3TRK A;  2AUX A;  2Y5B A;  3PHX A;  4PI3 A;  5JA7 A;  3CBK A;  1ME3 A;  3N3G A;  3O1G A;  2F7D A;  3IEJ A;  2DC6 A;  4HXD B;  5CVO B;  1MIR A;  4P6E A;  1U9V A;  3KSE A;  2YJB A;  1EF7 A;  3WXE A;  2XU1 A;  4XZX A;  2DC7 A;  1TU6 A;  7PCK A;  1AEC A;  1KHP A;  4AXL A;  1GMY A;  2AVW A;  2VHF A;  5E6J A;  2BTW B;  4DMY A;  2JQF R;  1PVJ A;  3LXS A;  3E9S A;  4BS5 A;  3LFY A;  2VHS A;  3QT4 A;  3W31 A;  1Y08 A;  3ERV A;  1PE6 A;  2P86 A;  4R3D A;  1GCB A;  1U9X A;  1BGO A;  3C9E A;  1PXV A;  4YV8 A;  2FRA A;  1PPN A;  2HXZ A;  1GEC E;  1Y4H A;  4MM3 B;  3ZUA A;  1U9Q X;  2AYN A;  1PBH A;  3M99 A;  1DEU A;  4GUA A;  1UKF A;  4WUR A;  1QMY A;  3P5U A;  4BSQ A;  2Z84 A;  1BQI A;  1SNK A;  5PAD A;  4BS6 A;  3PHW A;  4FJC A;  1DF0 A;  2FRQ A;  4D8B A;  3P5V A;  2R9F A;  4WA6 A;  3RVV A;  4MI7 A;  2DC9 A;  4I04 A;  2NQA A;  5A24 A;  1YK7 A;  2R9M A;  3O65 A;  2PNS A;  2YJ2 A;  5K16 A;  3OQC A;  3MP2 A;  3HD3 A;  4KLB A;  2R9C A;  5EZQ A;  2GHU A;  3NHE A;  4CDD B;  2NQG A;  3CH2 X;  1O0E A;  2FUD A;  5J94 A;  3F75 A;  3IOQ A;  1K3B B;  2DOS A;  2R6N A;  3BBA A;  4CZW A;  3KKU A;  4BOQ A;  2PRE A;  1CTE A;  4YYS A;  1QXP A;  3KX1 A;  1F2C A;  1NLJ A;  2AU1 A;  2OP3 A;  4A5U A;  4BQV A;  3MTN A;  1SP4 B;  3F5V A;  1AIM A;  5FPW A;  4K7C A;  4W5C A;  5CVN B;  1YAL A;  4FIP A;  2B1N A;  2AYO A;  4REZ A;  4DMX A;  3S3Q A;  4M0W A;  1EWM A;  2YJ9 A;  4YVA A;  3C0R A;  4P16 A;  3HHI A;  3IFU A;  2FO5 A;  4XR7 A;  3H6S A;  1AYW A;  4YYU A;  2ARY A;  1ICF A;  2NQD B;  3H8C A;  1ITO A;  2BU3 A;  3KWZ A;  3U8E A;  1CB5 A;  4ZUX U;  3OVZ A;  4D8E A;  1AU0 A;  2R9O A;  3HHA A;  3PDF A;  3K8U A;  1EWO A;  3MTV A;  2C0Y A;  3BCN A;  2HD5 A;  3WXG A;  2HWK A;  3W30 A;  4BPV A;  3HWN A;  4FK5 A;  4BOZ A;  2E01 A;  2FT2 A;  1CV8 A;  4P6G A;  4XUI A;  1AU4 A;  1BP4 A;  4N4Z A;  4YYR A;  2P7U A;  1PPO A;  4ZTB A;  5F02 A;  3E1Z B;  3QSD A;  3P5W A;  4OEL A;  4W5B A;  1CQD A;  3B79 A;  1MEM A;  2AIM A;  3IUT A;  2XU3 A;  4I07 A;  1U9W A;  2FYE A;  2FE8 A;  3PRP A;  4BOS A;  1TL9 A;  1M6D A;  1CVZ A;  4OVZ A; 
#chains in the Genus database with same CATH homology
 3OQC A;  3MP2 A;  1DKI A;  5EZQ A;  4RF1 A;  2JTC A;  4RF0 A;  2DOS A;  4IP3 A;  3B21 A;  3BBA A;  4BOQ A;  5KO3 A;  3PHU A;  4A5U A;  3TRK A;  3PHX A;  4RNA A;  4OW0 A;  4HXD B;  3PT2 A;  3ZNH A;  4REZ A;  4M0W A;  4PT5 A;  3C0R A;  4P16 A;  2J7Q A;  3IFU A;  4XZX A;  2JRI A;  4BOU A;  2J7Q C;  4BOP A;  5E6J A;  2BTW B;  2BU3 A;  5EZS A;  1PVJ A;  3E9S A;  4D8E A;  3MTV A;  3W31 A;  3BY4 A;  4R3D A;  2HWK A;  2UZJ A;  4OVZ B;  3W30 A;  1YZB A;  3MJ5 A;  3PSE A;  3BB7 A;  3TMP A;  3PRM A;  4RKX A;  4BOZ A;  4MM3 B;  2AGA A;  4GUA A;  4IUM A;  1UKF A;  4WUR A;  2BTW A;  2Z84 A;  4ZTB A;  5JZE A;  4D8I A;  3PHW A;  4D8B A;  3RNV A;  4MI7 A;  2FE8 A;  3PRP A;  4BOS A;  3O65 A;  4OVZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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