4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Streptopain
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
4D8IA 3BB7A 4RKXA 1PVJA 2UZJA 4D8EA 1DKIA 4D8BA 2JTCA 3BBAA
chains in the Genus database with same CATH superfamily
4YYVA 2R9MA 3LFYA 2OZ2A 2BDZA 4P16A 2P0RA 2E03A 2OULA 3B21A 2G6DA 1YALA 2DZZA 1PADA 1Y08A 1ITOA 4CZWA 1DEUA 2DC8A 2DJGB 1NB5A 4AXLA 2PNSA 2IBIA 1KXRA 1X9YA 3MTNA 2BTWB 3F75A 4PI3A 3I3TA 3TMPA 4BSQA 3DF0A 1AYUA 4X6JA 2YJ8A 4I04A 3LXSA 5EGWA 3USVA 1AU0A 2O6XA 2R9CA 4YYUA 1U9XA 3V6CA 1YT7A 4REZA 4G54A 3CH2X 1EWOA 4YV8A 3V6EA 1BP4A 3E9SA 1VSNA 5K16A 3S3QA 5CHVA 1AU3A 4PT5A 1MIRA 1SP4B 1AU4A 5EZSA 4XZXA 1ICFA 4GUAA 2JQFR 3K24A 3BY4A 4N8WA 1GMYA 4YYRA 1O0EA 2JRIA 3O1GA 3IHPA 2GHUA 1POPA 1UKFA 1TL9A 2E02A 2FYEA 2YJ2A 3KFQA 3P5WA 3H6SA 5JA7A 1PVJA 1ZCMA 1F29A 1CS8A 3HWNA 5JH3A 1CVZA 3TNXA 4QRXA 2ARYA 2Y6EA 4IP3A 4Q8GA 4YVAA 3N4CA 4R3DA 1NB3A 1BQIA 5F02A 4QH6A 5PADA 3RVXA 2JQGR 1IWDA 1QOLA 4WA6A 4W4UA 1EWPA 2FRAA 2XU4A 3PSEA 1KFUL 5FPWA 2P7UA 2FQ9A 2BTWA 5CVOB 3KWBX 3N3KA 4D8BA 2BDLA 1YK7A 7PCKA 4FJCA 4MZOA 4P6EA 1NLJA 3HHIA 3QT4A 4XR7A 3K8UA 3MHSA 4YYSA 8PCHA 3K9MA 1STFE 3BOWA 3RNVA 2AVWA 4X6IA 1PIPA 2XU5A 3IMAA 1KHQA 3KW9A 3IFUA 1CTEA 1Y4HA 3H8BA 4WURA 2HH5A 1DF0A 3PRMA 1MHWA 3HHAA 2AUZA 4HXDB 3QSDA 1TLOA 4Q8HA 4MZSA 3PHWA 3RVWA 1PPOA 4P6GA 1PPPA 1MDWA 1EWLA 2WBFX 1YVBA 4RKXA 1GECE 3PDFA 5CVNB 3PNRA 4BOQA 4X6HA 2E01A 4MI7A 4I07A 3OF8A 6PADA 4PP2E 3C0RA 3F5VA 4RF1A 3BCNA 1S4VA 2HD5A 1ATKA 1ZIVA 2J7QA 1CPJA 1CV8A 3N3GA 3BPFA 1THEA 2B1MA 4MM3B 5A24A 3BBAA 1AYVA 4ZTBA 2AYOA 2B1NA 3KX1A 2R6NA 2DCBA 2XU1A 2YJCA 2NQGA 4BS5A 3U8EA 3KWZA 3MJ5A 2YJBA 1YZBA 2DCAA 4IUMA 3WXFA 4RNAA 5KO3A 3AI8A 1BGOA 4YYQA 4ZUXU 1ME3A 1NL6A 4OVZB 3D6SA 1QXPA 5J94A 2ATOA 3BPMA 4CDCB 1DKIA 4OVZA 4FIPA 3RVVA 1PPDA 4BS6A 4OELA 4PADA 2DJFB 2NQIA 4XUIA 3MORA 2UZJA 3WXEA 4KLBA 1MEMA 1A6RA 3OQCA 2DC6A 4CDEB 2CIOA 1MS6A 3ZNHA 3IV2A 3ERVA 3NHEA 3OF9A 3HD3A 1U9QX 3CBKA 4K7CA 4W5CA 2AS8A 3ZUAA 4OEMA 3O65A 2FO5A 3B79A 4DMYA 3E1ZB 4D8EA 1AU2A 4MSXA 1NPZA 3W31A 2CB5A 1BY8A 1PXVA 3H8CA 2R9FA 2AGAA 2DOSA 3MTVA 3BC3A 2FRQA 4QRVA 5EF4A 2IPPB 2BU3A 4BPVA 1ME4A 2AYNA 2J7QC 4I05A 2PADA 3P5UA 4AXMA 3MHHA 2JTCA 3KKUA 2VHFA 5CVMA 1CSBB 4M0WA 2DCCA 1EF7A 3PBHA 3BWKA 1CB5A 1PE6A 3S3RA 4BOZA 2G8JA 3C9EA 2FE8A 2AIMA 3MP2A 1HUCB 2DC7A 1YK8A 2C0YA 4CDDB 1PBHA 2G8EA 2DCDA 3PHUA 1GCBA 1F2CA 3O0UA 5EZQA 4RY2A 1SNKA 1KHPA 4N79A 2DZYA 2R9NA 4OW0A 1NQCA 2NQDB 2NQAA 2FUDA 4BQVA 3IUTA 1F2BA 3OVZA 4YYWA 3PRPA 4QBBA 1TU6A 4W5BA 1EWMA 2PBHA 9PAPA 3W30A 1MEGA 2XU3A 2F1GA 2DC9A 4D8IA 1GLOA 3P5VA 1CQDA 1AECA 2PREA 2HHNA 2OP3A 1CJLA 2VHSA 2R9OA 4PP1A 3PT2A 5JZEA 3CH3X 1PPNA 4A5UA 1M6DA 3OISA 3IEJA 1QMYA 4HWYA 3GCBA 2E00A 2Z84A 1K3BB 3KSEA 5E6JA 3M99A 2H7JA 1U5IA 2AUXA 2FT2A 4N4ZA 1U9VA 1FH0A 3PW3A 2YJ9A 2FTDA 2ACTA 2F7DA 1KFXL 1Q6KA 1QDQA 3CBJA 1F2AA 2HXZA 2AU1A 3H89A 4CDFB 3OVXA 2P86A 4DMXA 2G7YA 3QJ3A 3BB7A 4RF0A 2GFOA 1PCIA 1U9WA 5CHTA 4QRGA 1XKGA 1JQPA 4FK5A 1AYWA 2Y5BA 1AIMA 3PHXA 3H7DA 3WXGA 3P5XA 3IOQA 3TRKA 4BOUA 1VJVA 3I06A 4BOSA 4BOPA 2HWKA
chains in the Genus database with same CATH topology
4D8IA 3C0RA 3BB7A 3TMPA 3W31A 4RF0A 4XZXA 2UZJA 4HXDB 4RF1A 5EZQA 2AGAA 2DOSA 3MJ5A 3MTVA 4GUAA 4P16A 3PHWA 5E6JA 3PSEA 1YZBA 4BOZA 3RNVA 3OQCA 3B21A 4IUMA 4OW0A 4RNAA 3BY4A 5KO3A 4IP3A 2BU3A 2FE8A 2BTWA 2J7QA 3MP2A 3IFUA 2JRIA 3PT2A 3ZNHA 4RKXA 5JZEA 4R3DA 2J7QC 3PHXA 4OVZB 4REZA 4A5UA 3PRPA 1UKFA 4WURA 4MM3B 3TRKA 1DKIA 3PRMA 4BOQA 3BBAA 2JTCA 3E9SA 4D8BA 3O65A 4ZTBA 3W30A 4MI7A 4OVZA 4BOUA 1PVJA 4BOSA 4PT5A 4D8EA 3PHUA 4BOPA 2HWKA 2BTWB 2Z84A 4M0WA 5EZSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  3BB7 A;  4RKX A;  1PVJ A;  2UZJ A;  4D8E A;  1DKI A;  4D8B A;  2JTC A;  3BBA A; 
#chains in the Genus database with same CATH topology
 4YYV A;  2R9M A;  3LFY A;  2OZ2 A;  2BDZ A;  4P16 A;  2P0R A;  2E03 A;  2OUL A;  3B21 A;  2G6D A;  1YAL A;  2DZZ A;  1PAD A;  1Y08 A;  1ITO A;  4CZW A;  1DEU A;  2DC8 A;  2DJG B;  1NB5 A;  4AXL A;  2PNS A;  2IBI A;  1KXR A;  1X9Y A;  3MTN A;  2BTW B;  3F75 A;  4PI3 A;  3I3T A;  3TMP A;  4BSQ A;  3DF0 A;  1AYU A;  4X6J A;  2YJ8 A;  4I04 A;  3LXS A;  5EGW A;  3USV A;  1AU0 A;  2O6X A;  2R9C A;  4YYU A;  1U9X A;  3V6C A;  1YT7 A;  4REZ A;  4G54 A;  3CH2 X;  1EWO A;  4YV8 A;  3V6E A;  1BP4 A;  3E9S A;  1VSN A;  5K16 A;  3S3Q A;  5CHV A;  1AU3 A;  4PT5 A;  1MIR A;  1SP4 B;  1AU4 A;  5EZS A;  4XZX A;  1ICF A;  4GUA A;  2JQF R;  3K24 A;  3BY4 A;  4N8W A;  1GMY A;  4YYR A;  1O0E A;  2JRI A;  3O1G A;  3IHP A;  2GHU A;  1POP A;  1UKF A;  1TL9 A;  2E02 A;  2FYE A;  2YJ2 A;  3KFQ A;  3P5W A;  3H6S A;  5JA7 A;  1PVJ A;  1ZCM A;  1F29 A;  1CS8 A;  3HWN A;  5JH3 A;  1CVZ A;  3TNX A;  4QRX A;  2ARY A;  2Y6E A;  4IP3 A;  4Q8G A;  4YVA A;  3N4C A;  4R3D A;  1NB3 A;  1BQI A;  5F02 A;  4QH6 A;  5PAD A;  3RVX A;  2JQG R;  1IWD A;  1QOL A;  4WA6 A;  4W4U A;  1EWP A;  2FRA A;  2XU4 A;  3PSE A;  1KFU L;  5FPW A;  2P7U A;  2FQ9 A;  2BTW A;  5CVO B;  3KWB X;  3N3K A;  4D8B A;  2BDL A;  1YK7 A;  7PCK A;  4FJC A;  4MZO A;  4P6E A;  1NLJ A;  3HHI A;  3QT4 A;  4XR7 A;  3K8U A;  3MHS A;  4YYS A;  8PCH A;  3K9M A;  1STF E;  3BOW A;  3RNV A;  2AVW A;  4X6I A;  1PIP A;  2XU5 A;  3IMA A;  1KHQ A;  3KW9 A;  3IFU A;  1CTE A;  1Y4H A;  3H8B A;  4WUR A;  2HH5 A;  1DF0 A;  3PRM A;  1MHW A;  3HHA A;  2AUZ A;  4HXD B;  3QSD A;  1TLO A;  4Q8H A;  4MZS A;  3PHW A;  3RVW A;  1PPO A;  4P6G A;  1PPP A;  1MDW A;  1EWL A;  2WBF X;  1YVB A;  4RKX A;  1GEC E;  3PDF A;  5CVN B;  3PNR A;  4BOQ A;  4X6H A;  2E01 A;  4MI7 A;  4I07 A;  3OF8 A;  6PAD A;  4PP2 E;  3C0R A;  3F5V A;  4RF1 A;  3BCN A;  1S4V A;  2HD5 A;  1ATK A;  1ZIV A;  2J7Q A;  1CPJ A;  1CV8 A;  3N3G A;  3BPF A;  1THE A;  2B1M A;  4MM3 B;  5A24 A;  3BBA A;  1AYV A;  4ZTB A;  2AYO A;  2B1N A;  3KX1 A;  2R6N A;  2DCB A;  2XU1 A;  2YJC A;  2NQG A;  4BS5 A;  3U8E A;  3KWZ A;  3MJ5 A;  2YJB A;  1YZB A;  2DCA A;  4IUM A;  3WXF A;  4RNA A;  5KO3 A;  3AI8 A;  1BGO A;  4YYQ A;  4ZUX U;  1ME3 A;  1NL6 A;  4OVZ B;  3D6S A;  1QXP A;  5J94 A;  2ATO A;  3BPM A;  4CDC B;  1DKI A;  4OVZ A;  4FIP A;  3RVV A;  1PPD A;  4BS6 A;  4OEL A;  4PAD A;  2DJF B;  2NQI A;  4XUI A;  3MOR A;  2UZJ A;  3WXE A;  4KLB A;  1MEM A;  1A6R A;  3OQC A;  2DC6 A;  4CDE B;  2CIO A;  1MS6 A;  3ZNH A;  3IV2 A;  3ERV A;  3NHE A;  3OF9 A;  3HD3 A;  1U9Q X;  3CBK A;  4K7C A;  4W5C A;  2AS8 A;  3ZUA A;  4OEM A;  3O65 A;  2FO5 A;  3B79 A;  4DMY A;  3E1Z B;  4D8E A;  1AU2 A;  4MSX A;  1NPZ A;  3W31 A;  2CB5 A;  1BY8 A;  1PXV A;  3H8C A;  2R9F A;  2AGA A;  2DOS A;  3MTV A;  3BC3 A;  2FRQ A;  4QRV A;  5EF4 A;  2IPP B;  2BU3 A;  4BPV A;  1ME4 A;  2AYN A;  2J7Q C;  4I05 A;  2PAD A;  3P5U A;  4AXM A;  3MHH A;  2JTC A;  3KKU A;  2VHF A;  5CVM A;  1CSB B;  4M0W A;  2DCC A;  1EF7 A;  3PBH A;  3BWK A;  1CB5 A;  1PE6 A;  3S3R A;  4BOZ A;  2G8J A;  3C9E A;  2FE8 A;  2AIM A;  3MP2 A;  1HUC B;  2DC7 A;  1YK8 A;  2C0Y A;  4CDD B;  1PBH A;  2G8E A;  2DCD A;  3PHU A;  1GCB A;  1F2C A;  3O0U A;  5EZQ A;  4RY2 A;  1SNK A;  1KHP A;  4N79 A;  2DZY A;  2R9N A;  4OW0 A;  1NQC A;  2NQD B;  2NQA A;  2FUD A;  4BQV A;  3IUT A;  1F2B A;  3OVZ A;  4YYW A;  3PRP A;  4QBB A;  1TU6 A;  4W5B A;  1EWM A;  2PBH A;  9PAP A;  3W30 A;  1MEG A;  2XU3 A;  2F1G A;  2DC9 A;  4D8I A;  1GLO A;  3P5V A;  1CQD A;  1AEC A;  2PRE A;  2HHN A;  2OP3 A;  1CJL A;  2VHS A;  2R9O A;  4PP1 A;  3PT2 A;  5JZE A;  3CH3 X;  1PPN A;  4A5U A;  1M6D A;  3OIS A;  3IEJ A;  1QMY A;  4HWY A;  3GCB A;  2E00 A;  2Z84 A;  1K3B B;  3KSE A;  5E6J A;  3M99 A;  2H7J A;  1U5I A;  2AUX A;  2FT2 A;  4N4Z A;  1U9V A;  1FH0 A;  3PW3 A;  2YJ9 A;  2FTD A;  2ACT A;  2F7D A;  1KFX L;  1Q6K A;  1QDQ A;  3CBJ A;  1F2A A;  2HXZ A;  2AU1 A;  3H89 A;  4CDF B;  3OVX A;  2P86 A;  4DMX A;  2G7Y A;  3QJ3 A;  3BB7 A;  4RF0 A;  2GFO A;  1PCI A;  1U9W A;  5CHT A;  4QRG A;  1XKG A;  1JQP A;  4FK5 A;  1AYW A;  2Y5B A;  1AIM A;  3PHX A;  3H7D A;  3WXG A;  3P5X A;  3IOQ A;  3TRK A;  4BOU A;  1VJV A;  3I06 A;  4BOS A;  4BOP A;  2HWK A; 
#chains in the Genus database with same CATH homology
 4D8I A;  3C0R A;  3BB7 A;  3TMP A;  3W31 A;  4RF0 A;  4XZX A;  2UZJ A;  4HXD B;  4RF1 A;  5EZQ A;  2AGA A;  2DOS A;  3MJ5 A;  3MTV A;  4GUA A;  4P16 A;  3PHW A;  5E6J A;  3PSE A;  1YZB A;  4BOZ A;  3RNV A;  3OQC A;  3B21 A;  4IUM A;  4OW0 A;  4RNA A;  3BY4 A;  5KO3 A;  4IP3 A;  2BU3 A;  2FE8 A;  2BTW A;  2J7Q A;  3MP2 A;  3IFU A;  2JRI A;  3PT2 A;  3ZNH A;  4RKX A;  5JZE A;  4R3D A;  2J7Q C;  3PHX A;  4OVZ B;  4REZ A;  4A5U A;  3PRP A;  1UKF A;  4WUR A;  4MM3 B;  3TRK A;  1DKI A;  3PRM A;  4BOQ A;  3BBA A;  2JTC A;  3E9S A;  4D8B A;  3O65 A;  4ZTB A;  3W30 A;  4MI7 A;  4OVZ A;  4BOU A;  1PVJ A;  4BOS A;  4PT5 A;  4D8E A;  3PHU A;  4BOP A;  2HWK A;  2BTW B;  2Z84 A;  4M0W A;  5EZS A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...