3OF9A

Structural basis for irreversible inhibition of human cathepsin l by a diazomethylketone inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
221
structure length
221
Chain Sequence
EAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Cathepsin L1
publication title Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
total genus 67
structure length 221
sequence length 221
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2010-08-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3of9A00
1MS6A 2E02A 2NQAA 2DC7A 1PIPA 1AU0A 4CDDB 2XU5A 3IV2A 3CH3X 4YYVA 2GHUA 4K7CA 2PBHA 1U9XA 4MZOA 1F2AA 4PP1A 2PADA 5EF4A 3TNXA 2BDZA 3ZUAA 3H8BA 3OVXA 3O1GA 3P5WA 2FYEA 1F2BA 1KFXL 1CJLA 3ERVA 3O0UA 2NQGA 3M99A 3KFQA 1Q6KA 3WXGA 1CQDA 4CDCB 3P5XA 2FUDA 1YT7A 3V6EA 3MORA 2H7JA 2HD5A 3AI8A 6PADA 4CZWA 4PI3A 2AS8A 2DZYA 1AYVA 1CSBB 4BQVA 4N4ZA 3WXFA 5EGWA 1AECA 3IHPA 2OP3A 1GLOA 2E03A 2O6XA 4QRXA 2E01A 4YYQA 2WBFX 1NPZA 2YJ2A 3H89A 2HH5A 1QXPA 3BOWA 3E1ZB 1NB5A 1ZCMA 1TU6A 4Q8GA 1EF7A 4W5BA 3RVVA 4MZSA 5JH3A 1MHWA 4PADA 1QMYA 3LFYA 3C9EA 3BCNA 2PREA 2F7DA 3D6SA 3OISA 2HXZA 2R9CA 1S4VA 3QSDA 1XKGA 2R9FA 4FJCA 1U9WA 2DC9A 2Y6EA 2FO5A 1PADA 1F29A 2OZ2A 3OVZA 4AXLA 2IBIA 2AUXA 1MDWA 2R9MA 4YYWA 5CHTA 1EWMA 3BPFA 1PBHA 3OF8A 3MHHA 1EWPA 3IOQA 1TL9A 1ATKA 2CB5A 3QJ3A 2R9OA 5CVMA 2ACTA 2G7YA 1VSNA 3MHSA 2PNSA 1AYWA 2R6NA 1VJVA 3LXSA 1CTEA 4DMYA 1HUCB 3BC3A 2G8JA 1EWLA 5A24A 1PE6A 2E00A 7PCKA 1U9QX 4X6HA 1U9VA 1AYUA 2AYOA 3IUTA 1Y08A 1NQCA 1MIRA 4OELA 1M6DA 4N79A 3PBHA 4FIPA 1MEMA 1BGOA 3DF0A 1DF0A 4CDEB 2B1MA 1BP4A 1JQPA 5CVOB 3BPMA 3H7DA 4Q8HA 1AU3A 1POPA 1BQIA 3N3KA 4XUIA 1GECE 3K24A 4X6JA 5CVNB 3K8UA 3B79A 2JQGR 2FRQA 2XU1A 3PDFA 1NL6A 2DJGB 4BSQA 2P7UA 1CVZA 3WXEA 3KKUA 3KW9A 1MEGA 1NLJA 4WA6A 2DCAA 3HWNA 3QT4A 5F02A 3KX1A 4BS6A 3I3TA 2P86A 1KHQA 1IWDA 3OF9A 2YJCA 4KLBA 1GMYA 2DC6A 3KSEA 3NHEA 3P5UA 2FTDA 1CPJA 1KXRA 2CIOA 4QH6A 2XU3A 4OEMA 2DCDA 1EWOA 1YK8A 1PPOA 2VHSA 3CH2X 2G6DA 1GCBA 1O0EA 1K3BB 4PP2E 2B1NA 1ICFA 1PXVA 4FK5A 2AYNA 3KWZA 3BWKA 3IMAA 3RVXA 1ITOA 4N8WA 5FPWA 2AU1A 1PPPA 1CB5A 3GCBA 4YYSA 1SP4B 4XR7A 1X9YA 4HWYA 5JA7A 2F1GA 1PPNA 2P0RA 2G8EA 8PCHA 2XU4A 3S3QA 3N3GA 1TLOA 1U5IA 1ZIVA 1KHPA 4I05A 2BDLA 2IPPB 5K16A 4I04A 3CBJA 1CS8A 2AUZA 3IEJA 2C0YA 1AU4A 4BS5A 4P6EA 4G54A 1FH0A 1YVBA 2DC8A 2DJFB 3MTNA 3USVA 4MSXA 3HHAA 1STFE 4P6GA 2YJ8A 5J94A 2ARYA 1BY8A 3RVWA 2Y5BA 4DMXA 2HHNA 1CV8A 4ZUXU 3I06A 4YYRA 1QDQA 3CBKA 2DCBA 4YVAA 3H8CA 3PNRA 1AIMA 3PW3A 2AIMA 1ME4A 2VHFA 2FT2A 1THEA 1A6RA 1NB3A 1YK7A 1YALA 3F5VA 1SNKA 1F2CA 3V6CA 2DCCA 3P5VA 4I07A 1QOLA 4YV8A 1ME3A 3K9MA 2GFOA 4W4UA 2NQIA 2FRAA 2AVWA 2YJBA 1DEUA 2ATOA 3HD3A 5CHVA 3N4CA 4QBBA 5PADA 4CDFB 4QRVA 3U8EA 3F75A 2OULA 4W5CA 1Y4HA 2JQFR 2YJ9A 2DZZA 3KWBX 3S3RA 4BPVA 4X6IA 4RY2A 4AXMA 2NQDB 3H6SA 1AU2A 3HHIA 1PCIA 9PAPA 4QRGA 4YYUA 2R9NA 1PPDA 1KFUL 2FQ9A
chains in the Genus database with same CATH superfamily
1MS6A 5EZSA 2E02A 2NQAA 2DC7A 1PIPA 1AU0A 4MI7A 4CDDB 2XU5A 3IV2A 4PT5A 3CH3X 4YYVA 2GHUA 4K7CA 2PBHA 1U9XA 4MZOA 1F2AA 3TRKA 4PP1A 4GUAA 2PADA 5EF4A 3TNXA 2BDZA 3ZUAA 3PHWA 3H8BA 3OVXA 3O1GA 3P5WA 2FYEA 1F2BA 1KFXL 1CJLA 3ERVA 3O0UA 3MP2A 4OVZB 2NQGA 3M99A 3KFQA 1Q6KA 3WXGA 1CQDA 4CDCB 3P5XA 2FUDA 2FE8A 1YT7A 3V6EA 3MORA 3MTVA 2H7JA 2HD5A 3AI8A 4OW0A 6PADA 4CZWA 4RNAA 4PI3A 2AS8A 2DZYA 1AYVA 1CSBB 2Z84A 4BQVA 4N4ZA 3WXFA 3PSEA 5EGWA 1AECA 3IHPA 2J7QA 2OP3A 1GLOA 2E03A 2O6XA 4QRXA 2E01A 4YYQA 2WBFX 1NPZA 2YJ2A 3H89A 2HH5A 1QXPA 3BOWA 3E1ZB 1NB5A 4ZTBA 1ZCMA 1TU6A 4Q8GA 1EF7A 4W5BA 3RVVA 4MZSA 5JH3A 1MHWA 4PADA 4RF0A 1QMYA 3LFYA 3BB7A 3C9EA 3BCNA 2PREA 4RF1A 2F7DA 3D6SA 3OISA 2HXZA 2R9CA 1S4VA 3QSDA 1XKGA 2R9FA 4FJCA 1U9WA 2DC9A 3E9SA 2Y6EA 2FO5A 1PADA 1F29A 2OZ2A 2BTWA 4IUMA 3OVZA 4AXLA 2IBIA 2AUXA 3W30A 1MDWA 2R9MA 4YYWA 5CHTA 1EWMA 3BPFA 1PBHA 4D8EA 3OF8A 3MHHA 1EWPA 3IOQA 1TL9A 1ATKA 2AGAA 2CB5A 3QJ3A 2R9OA 5CVMA 2ACTA 2G7YA 1VSNA 3MHSA 2PNSA 1AYWA 2R6NA 5JZEA 1VJVA 4RKXA 3LXSA 1CTEA 4DMYA 1HUCB 3BC3A 2UZJA 2G8JA 1EWLA 5A24A 1PE6A 2E00A 7PCKA 1U9QX 2JTCA 4REZA 3B21A 4X6HA 1U9VA 1AYUA 2AYOA 3IUTA 1Y08A 1NQCA 5E6JA 1MIRA 4OELA 1M6DA 4N79A 3PBHA 4FIPA 1MEMA 1BGOA 3DF0A 1DF0A 4CDEB 2B1MA 1BP4A 1JQPA 5CVOB 3BPMA 4R3DA 3H7DA 4Q8HA 1AU3A 1POPA 2JRIA 3ZNHA 1BQIA 3N3KA 4M0WA 4XUIA 1GECE 3K24A 4X6JA 5CVNB 3K8UA 2BU3A 3B79A 3IFUA 2JQGR 2FRQA 2XU1A 3PDFA 1NL6A 2DJGB 3PHXA 4BSQA 2P7UA 1CVZA 3WXEA 3KKUA 3KW9A 1MEGA 1NLJA 4WA6A 2DCAA 3HWNA 3QT4A 5F02A 3KX1A 4BS6A 3I3TA 2P86A 1KHQA 1IWDA 3OF9A 2YJCA 3PHUA 4KLBA 1GMYA 2DC6A 3KSEA 3NHEA 3P5UA 2FTDA 1CPJA 1KXRA 4P16A 2CIOA 4QH6A 2XU3A 4OEMA 1DKIA 1UKFA 2DCDA 1EWOA 1YK8A 1PPOA 2VHSA 2HWKA 3CH2X 2G6DA 1GCBA 1O0EA 1K3BB 4PP2E 2B1NA 1ICFA 4A5UA 1PXVA 2BTWB 4FK5A 2AYNA 3KWZA 3BWKA 3IMAA 3RVXA 1ITOA 3C0RA 4N8WA 5FPWA 2AU1A 1PPPA 1CB5A 3GCBA 4YYSA 1SP4B 4XR7A 1X9YA 4HWYA 5JA7A 2F1GA 1PPNA 2P0RA 2G8EA 8PCHA 2XU4A 4BOUA 3S3QA 3N3GA 1TLOA 1U5IA 1ZIVA 4BOZA 1KHPA 4I05A 4BOQA 4HXDB 2BDLA 2IPPB 1YZBA 5K16A 4I04A 3CBJA 5EZQA 1CS8A 2AUZA 3IEJA 3PT2A 2C0YA 1AU4A 3MJ5A 4BS5A 4P6EA 4G54A 1FH0A 2J7QC 1YVBA 4OVZA 2DC8A 2DJFB 3MTNA 3USVA 3BBAA 4MSXA 3HHAA 1STFE 4P6GA 2YJ8A 5J94A 2ARYA 1BY8A 3RVWA 4MM3B 2Y5BA 4DMXA 2HHNA 1CV8A 4IP3A 4WURA 4ZUXU 3I06A 4YYRA 1QDQA 3CBKA 2DOSA 2DCBA 4YVAA 3H8CA 3PNRA 1AIMA 3PW3A 5KO3A 2AIMA 1ME4A 2VHFA 2FT2A 3TMPA 1THEA 3BY4A 1A6RA 1NB3A 1YK7A 1YALA 3F5VA 1SNKA 1F2CA 3V6CA 2DCCA 1PVJA 3P5VA 3OQCA 1QOLA 4I07A 4YV8A 1ME3A 3K9MA 3PRMA 2GFOA 4W4UA 2NQIA 2FRAA 2AVWA 2YJBA 1DEUA 2ATOA 3HD3A 4XZXA 4D8BA 5CHVA 4BOSA 3N4CA 4QBBA 5PADA 4CDFB 4QRVA 3U8EA 3W31A 3RNVA 3F75A 2OULA 4W5CA 1Y4HA 2JQFR 2YJ9A 4BOPA 2DZZA 3KWBX 3S3RA 4BPVA 4X6IA 4D8IA 4RY2A 4AXMA 2NQDB 3PRPA 3H6SA 3O65A 1AU2A 3HHIA 1PCIA 9PAPA 4QRGA 4YYUA 2R9NA 1PPDA 1KFUL 2FQ9A
chains in the Genus database with same CATH topology
1MS6A 2E02A 2NQAA 2DC7A 1PIPA 1AU0A 4CDDB 2XU5A 3IV2A 3CH3X 4YYVA 2GHUA 4K7CA 2PBHA 1U9XA 4MZOA 1F2AA 4PP1A 2PADA 5EF4A 3TNXA 2BDZA 3ZUAA 3H8BA 3OVXA 3O1GA 3P5WA 2FYEA 1F2BA 1KFXL 1CJLA 3ERVA 3O0UA 2NQGA 3M99A 3KFQA 1Q6KA 3WXGA 1CQDA 4CDCB 3P5XA 2FUDA 1YT7A 3V6EA 3MORA 2H7JA 2HD5A 3AI8A 6PADA 4CZWA 4PI3A 2AS8A 2DZYA 1AYVA 1CSBB 4BQVA 1E2TA 4N4ZA 3WXFA 5EGWA 1AECA 3IHPA 2OP3A 1GLOA 2E03A 2O6XA 4QRXA 2E01A 4YYQA 2WBFX 1NPZA 2YJ2A 3H89A 2HH5A 1QXPA 3BOWA 4NV7A 3E1ZB 1NB5A 1ZCMA 1TU6A 4Q8GA 1EF7A 4W5BA 3RVVA 4MZSA 5JH3A 1MHWA 4PADA 1QMYA 3LFYA 3C9EA 3BCNA 2PREA 2F7DA 3D6SA 3OISA 2HXZA 2R9CA 1S4VA 3QSDA 1XKGA 2R9FA 4FJCA 1U9WA 2DC9A 2Y6EA 1W5RA 2FO5A 1PADA 1F29A 2OZ2A 3OVZA 4AXLA 2IBIA 2AUXA 2VFBA 1MDWA 2R9MA 4YYWA 5CHTA 1EWMA 3BPFA 1PBHA 2VFCA 3OF8A 3MHHA 1EWPA 3IOQA 1TL9A 1ATKA 2CB5A 3QJ3A 2R9OA 5CVMA 2ACTA 2G7YA 1VSNA 3MHSA 2PNSA 1AYWA 2R6NA 1VJVA 3LXSA 1CTEA 4DMYA 1GX3A 1HUCB 3BC3A 2G8JA 1EWLA 5A24A 1PE6A 2E00A 7PCKA 1U9QX 4X6HA 1U9VA 1AYUA 2AYOA 3IUTA 1Y08A 1NQCA 1MIRA 4OELA 1M6DA 4N79A 2BSZA 3PBHA 4FIPA 1MEMA 1BGOA 3DF0A 1DF0A 4CDEB 2B1MA 1BP4A 1JQPA 5CVOB 3BPMA 3H7DA 4Q8HA 1AU3A 1POPA 1BQIA 3N3KA 4XUIA 1GECE 3K24A 4X6JA 5CVNB 3K8UA 3B79A 2JQGR 2FRQA 2XU1A 3PDFA 1NL6A 2DJGB 3LTWA 4BSQA 2P7UA 1CVZA 3WXEA 3KKUA 3KW9A 1MEGA 1NLJA 4WA6A 2DCAA 3HWNA 3QT4A 5F02A 3KX1A 4BS6A 3I3TA 2P86A 1KHQA 1IWDA 3OF9A 2YJCA 4KLBA 1GMYA 2DC6A 3KSEA 4C5PA 1W6FA 3NHEA 3P5UA 2FTDA 1CPJA 1KXRA 2CIOA 4QH6A 2XU3A 4OEMA 2DCDA 1EWOA 1YK8A 1PPOA 2VHSA 3CH2X 2G6DA 1GCBA 1O0EA 1K3BB 4PP2E 2B1NA 3D9WA 1ICFA 1PXVA 4FK5A 2AYNA 3KWZA 4BGFA 3BWKA 3IMAA 3RVXA 1ITOA 4N8WA 5FPWA 2AU1A 1PPPA 1CB5A 3GCBA 4YYSA 1SP4B 4XR7A 1X9YA 4HWYA 5JA7A 2F1GA 1PPNA 2P0RA 2G8EA 8PCHA 2XU4A 3S3QA 3N3GA 1TLOA 1U5IA 1ZIVA 4NV8A 1KHPA 4I05A 2BDLA 2IPPB 5K16A 1W4TA 4I04A 3CBJA 1CS8A 2AUZA 3IEJA 2C0YA 1AU4A 4BS5A 4P6EA 4G54A 1FH0A 1YVBA 2DC8A 2DJFB 3MTNA 3USVA 4B55A 4MSXA 3HHAA 1STFE 4P6GA 2YJ8A 5J94A 2ARYA 1BY8A 3RVWA 2Y5BA 4DMXA 2HHNA 1CV8A 4ZUXU 3I06A 4YYRA 1QDQA 3CBKA 2DCBA 4YVAA 3H8CA 3PNRA 1AIMA 3PW3A 2AIMA 1ME4A 2VHFA 4GUZA 2FT2A 1THEA 1A6RA 1NB3A 1YK7A 1YALA 3F5VA 1SNKA 1F2CA 3V6CA 2DCCA 3P5VA 4I07A 1QOLA 4YV8A 1ME3A 3K9MA 2GFOA 4W4UA 2NQIA 2FRAA 2AVWA 2YJBA 1DEUA 2ATOA 3HD3A 5CHVA 3N4CA 4QBBA 5PADA 4CDFB 4QRVA 3U8EA 3F75A 2OULA 4W5CA 1Y4HA 2JQFR 2YJ9A 2DZZA 3KWBX 3S3RA 4BPVA 4X6IA 4RY2A 4AXMA 2NQDB 3H6SA 1AU2A 3HHIA 1PCIA 9PAPA 4QRGA 4YYUA 2R9NA 1PPDA 1KFUL 2FQ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MS6 A;  2E02 A;  2NQA A;  2DC7 A;  1PIP A;  1AU0 A;  4CDD B;  2XU5 A;  3IV2 A;  3CH3 X;  4YYV A;  2GHU A;  4K7C A;  2PBH A;  1U9X A;  4MZO A;  1F2A A;  4PP1 A;  2PAD A;  5EF4 A;  3TNX A;  2BDZ A;  3ZUA A;  3H8B A;  3OVX A;  3O1G A;  3P5W A;  2FYE A;  1F2B A;  1KFX L;  1CJL A;  3ERV A;  3O0U A;  2NQG A;  3M99 A;  3KFQ A;  1Q6K A;  3WXG A;  1CQD A;  4CDC B;  3P5X A;  2FUD A;  1YT7 A;  3V6E A;  3MOR A;  2H7J A;  2HD5 A;  3AI8 A;  6PAD A;  4CZW A;  4PI3 A;  2AS8 A;  2DZY A;  1AYV A;  1CSB B;  4BQV A;  4N4Z A;  3WXF A;  5EGW A;  1AEC A;  3IHP A;  2OP3 A;  1GLO A;  2E03 A;  2O6X A;  4QRX A;  2E01 A;  4YYQ A;  2WBF X;  1NPZ A;  2YJ2 A;  3H89 A;  2HH5 A;  1QXP A;  3BOW A;  3E1Z B;  1NB5 A;  1ZCM A;  1TU6 A;  4Q8G A;  1EF7 A;  4W5B A;  3RVV A;  4MZS A;  5JH3 A;  1MHW A;  4PAD A;  1QMY A;  3LFY A;  3C9E A;  3BCN A;  2PRE A;  2F7D A;  3D6S A;  3OIS A;  2HXZ A;  2R9C A;  1S4V A;  3QSD A;  1XKG A;  2R9F A;  4FJC A;  1U9W A;  2DC9 A;  2Y6E A;  2FO5 A;  1PAD A;  1F29 A;  2OZ2 A;  3OVZ A;  4AXL A;  2IBI A;  2AUX A;  1MDW A;  2R9M A;  4YYW A;  5CHT A;  1EWM A;  3BPF A;  1PBH A;  3OF8 A;  3MHH A;  1EWP A;  3IOQ A;  1TL9 A;  1ATK A;  2CB5 A;  3QJ3 A;  2R9O A;  5CVM A;  2ACT A;  2G7Y A;  1VSN A;  3MHS A;  2PNS A;  1AYW A;  2R6N A;  1VJV A;  3LXS A;  1CTE A;  4DMY A;  1HUC B;  3BC3 A;  2G8J A;  1EWL A;  5A24 A;  1PE6 A;  2E00 A;  7PCK A;  1U9Q X;  4X6H A;  1U9V A;  1AYU A;  2AYO A;  3IUT A;  1Y08 A;  1NQC A;  1MIR A;  4OEL A;  1M6D A;  4N79 A;  3PBH A;  4FIP A;  1MEM A;  1BGO A;  3DF0 A;  1DF0 A;  4CDE B;  2B1M A;  1BP4 A;  1JQP A;  5CVO B;  3BPM A;  3H7D A;  4Q8H A;  1AU3 A;  1POP A;  1BQI A;  3N3K A;  4XUI A;  1GEC E;  3K24 A;  4X6J A;  5CVN B;  3K8U A;  3B79 A;  2JQG R;  2FRQ A;  2XU1 A;  3PDF A;  1NL6 A;  2DJG B;  4BSQ A;  2P7U A;  1CVZ A;  3WXE A;  3KKU A;  3KW9 A;  1MEG A;  1NLJ A;  4WA6 A;  2DCA A;  3HWN A;  3QT4 A;  5F02 A;  3KX1 A;  4BS6 A;  3I3T A;  2P86 A;  1KHQ A;  1IWD A;  3OF9 A;  2YJC A;  4KLB A;  1GMY A;  2DC6 A;  3KSE A;  3NHE A;  3P5U A;  2FTD A;  1CPJ A;  1KXR A;  2CIO A;  4QH6 A;  2XU3 A;  4OEM A;  2DCD A;  1EWO A;  1YK8 A;  1PPO A;  2VHS A;  3CH2 X;  2G6D A;  1GCB A;  1O0E A;  1K3B B;  4PP2 E;  2B1N A;  1ICF A;  1PXV A;  4FK5 A;  2AYN A;  3KWZ A;  3BWK A;  3IMA A;  3RVX A;  1ITO A;  4N8W A;  5FPW A;  2AU1 A;  1PPP A;  1CB5 A;  3GCB A;  4YYS A;  1SP4 B;  4XR7 A;  1X9Y A;  4HWY A;  5JA7 A;  2F1G A;  1PPN A;  2P0R A;  2G8E A;  8PCH A;  2XU4 A;  3S3Q A;  3N3G A;  1TLO A;  1U5I A;  1ZIV A;  1KHP A;  4I05 A;  2BDL A;  2IPP B;  5K16 A;  4I04 A;  3CBJ A;  1CS8 A;  2AUZ A;  3IEJ A;  2C0Y A;  1AU4 A;  4BS5 A;  4P6E A;  4G54 A;  1FH0 A;  1YVB A;  2DC8 A;  2DJF B;  3MTN A;  3USV A;  4MSX A;  3HHA A;  1STF E;  4P6G A;  2YJ8 A;  5J94 A;  2ARY A;  1BY8 A;  3RVW A;  2Y5B A;  4DMX A;  2HHN A;  1CV8 A;  4ZUX U;  3I06 A;  4YYR A;  1QDQ A;  3CBK A;  2DCB A;  4YVA A;  3H8C A;  3PNR A;  1AIM A;  3PW3 A;  2AIM A;  1ME4 A;  2VHF A;  2FT2 A;  1THE A;  1A6R A;  1NB3 A;  1YK7 A;  1YAL A;  3F5V A;  1SNK A;  1F2C A;  3V6C A;  2DCC A;  3P5V A;  4I07 A;  1QOL A;  4YV8 A;  1ME3 A;  3K9M A;  2GFO A;  4W4U A;  2NQI A;  2FRA A;  2AVW A;  2YJB A;  1DEU A;  2ATO A;  3HD3 A;  5CHV A;  3N4C A;  4QBB A;  5PAD A;  4CDF B;  4QRV A;  3U8E A;  3F75 A;  2OUL A;  4W5C A;  1Y4H A;  2JQF R;  2YJ9 A;  2DZZ A;  3KWB X;  3S3R A;  4BPV A;  4X6I A;  4RY2 A;  4AXM A;  2NQD B;  3H6S A;  1AU2 A;  3HHI A;  1PCI A;  9PAP A;  4QRG A;  4YYU A;  2R9N A;  1PPD A;  1KFU L;  2FQ9 A; 
#chains in the Genus database with same CATH topology
 1MS6 A;  5EZS A;  2E02 A;  2NQA A;  2DC7 A;  1PIP A;  1AU0 A;  4MI7 A;  4CDD B;  2XU5 A;  3IV2 A;  4PT5 A;  3CH3 X;  4YYV A;  2GHU A;  4K7C A;  2PBH A;  1U9X A;  4MZO A;  1F2A A;  3TRK A;  4PP1 A;  4GUA A;  2PAD A;  5EF4 A;  3TNX A;  2BDZ A;  3ZUA A;  3PHW A;  3H8B A;  3OVX A;  3O1G A;  3P5W A;  2FYE A;  1F2B A;  1KFX L;  1CJL A;  3ERV A;  3O0U A;  3MP2 A;  4OVZ B;  2NQG A;  3M99 A;  3KFQ A;  1Q6K A;  3WXG A;  1CQD A;  4CDC B;  3P5X A;  2FUD A;  2FE8 A;  1YT7 A;  3V6E A;  3MOR A;  3MTV A;  2H7J A;  2HD5 A;  3AI8 A;  4OW0 A;  6PAD A;  4CZW A;  4RNA A;  4PI3 A;  2AS8 A;  2DZY A;  1AYV A;  1CSB B;  2Z84 A;  4BQV A;  4N4Z A;  3WXF A;  3PSE A;  5EGW A;  1AEC A;  3IHP A;  2J7Q A;  2OP3 A;  1GLO A;  2E03 A;  2O6X A;  4QRX A;  2E01 A;  4YYQ A;  2WBF X;  1NPZ A;  2YJ2 A;  3H89 A;  2HH5 A;  1QXP A;  3BOW A;  3E1Z B;  1NB5 A;  4ZTB A;  1ZCM A;  1TU6 A;  4Q8G A;  1EF7 A;  4W5B A;  3RVV A;  4MZS A;  5JH3 A;  1MHW A;  4PAD A;  4RF0 A;  1QMY A;  3LFY A;  3BB7 A;  3C9E A;  3BCN A;  2PRE A;  4RF1 A;  2F7D A;  3D6S A;  3OIS A;  2HXZ A;  2R9C A;  1S4V A;  3QSD A;  1XKG A;  2R9F A;  4FJC A;  1U9W A;  2DC9 A;  3E9S A;  2Y6E A;  2FO5 A;  1PAD A;  1F29 A;  2OZ2 A;  2BTW A;  4IUM A;  3OVZ A;  4AXL A;  2IBI A;  2AUX A;  3W30 A;  1MDW A;  2R9M A;  4YYW A;  5CHT A;  1EWM A;  3BPF A;  1PBH A;  4D8E A;  3OF8 A;  3MHH A;  1EWP A;  3IOQ A;  1TL9 A;  1ATK A;  2AGA A;  2CB5 A;  3QJ3 A;  2R9O A;  5CVM A;  2ACT A;  2G7Y A;  1VSN A;  3MHS A;  2PNS A;  1AYW A;  2R6N A;  5JZE A;  1VJV A;  4RKX A;  3LXS A;  1CTE A;  4DMY A;  1HUC B;  3BC3 A;  2UZJ A;  2G8J A;  1EWL A;  5A24 A;  1PE6 A;  2E00 A;  7PCK A;  1U9Q X;  2JTC A;  4REZ A;  3B21 A;  4X6H A;  1U9V A;  1AYU A;  2AYO A;  3IUT A;  1Y08 A;  1NQC A;  5E6J A;  1MIR A;  4OEL A;  1M6D A;  4N79 A;  3PBH A;  4FIP A;  1MEM A;  1BGO A;  3DF0 A;  1DF0 A;  4CDE B;  2B1M A;  1BP4 A;  1JQP A;  5CVO B;  3BPM A;  4R3D A;  3H7D A;  4Q8H A;  1AU3 A;  1POP A;  2JRI A;  3ZNH A;  1BQI A;  3N3K A;  4M0W A;  4XUI A;  1GEC E;  3K24 A;  4X6J A;  5CVN B;  3K8U A;  2BU3 A;  3B79 A;  3IFU A;  2JQG R;  2FRQ A;  2XU1 A;  3PDF A;  1NL6 A;  2DJG B;  3PHX A;  4BSQ A;  2P7U A;  1CVZ A;  3WXE A;  3KKU A;  3KW9 A;  1MEG A;  1NLJ A;  4WA6 A;  2DCA A;  3HWN A;  3QT4 A;  5F02 A;  3KX1 A;  4BS6 A;  3I3T A;  2P86 A;  1KHQ A;  1IWD A;  3OF9 A;  2YJC A;  3PHU A;  4KLB A;  1GMY A;  2DC6 A;  3KSE A;  3NHE A;  3P5U A;  2FTD A;  1CPJ A;  1KXR A;  4P16 A;  2CIO A;  4QH6 A;  2XU3 A;  4OEM A;  1DKI A;  1UKF A;  2DCD A;  1EWO A;  1YK8 A;  1PPO A;  2VHS A;  2HWK A;  3CH2 X;  2G6D A;  1GCB A;  1O0E A;  1K3B B;  4PP2 E;  2B1N A;  1ICF A;  4A5U A;  1PXV A;  2BTW B;  4FK5 A;  2AYN A;  3KWZ A;  3BWK A;  3IMA A;  3RVX A;  1ITO A;  3C0R A;  4N8W A;  5FPW A;  2AU1 A;  1PPP A;  1CB5 A;  3GCB A;  4YYS A;  1SP4 B;  4XR7 A;  1X9Y A;  4HWY A;  5JA7 A;  2F1G A;  1PPN A;  2P0R A;  2G8E A;  8PCH A;  2XU4 A;  4BOU A;  3S3Q A;  3N3G A;  1TLO A;  1U5I A;  1ZIV A;  4BOZ A;  1KHP A;  4I05 A;  4BOQ A;  4HXD B;  2BDL A;  2IPP B;  1YZB A;  5K16 A;  4I04 A;  3CBJ A;  5EZQ A;  1CS8 A;  2AUZ A;  3IEJ A;  3PT2 A;  2C0Y A;  1AU4 A;  3MJ5 A;  4BS5 A;  4P6E A;  4G54 A;  1FH0 A;  2J7Q C;  1YVB A;  4OVZ A;  2DC8 A;  2DJF B;  3MTN A;  3USV A;  3BBA A;  4MSX A;  3HHA A;  1STF E;  4P6G A;  2YJ8 A;  5J94 A;  2ARY A;  1BY8 A;  3RVW A;  4MM3 B;  2Y5B A;  4DMX A;  2HHN A;  1CV8 A;  4IP3 A;  4WUR A;  4ZUX U;  3I06 A;  4YYR A;  1QDQ A;  3CBK A;  2DOS A;  2DCB A;  4YVA A;  3H8C A;  3PNR A;  1AIM A;  3PW3 A;  5KO3 A;  2AIM A;  1ME4 A;  2VHF A;  2FT2 A;  3TMP A;  1THE A;  3BY4 A;  1A6R A;  1NB3 A;  1YK7 A;  1YAL A;  3F5V A;  1SNK A;  1F2C A;  3V6C A;  2DCC A;  1PVJ A;  3P5V A;  3OQC A;  1QOL A;  4I07 A;  4YV8 A;  1ME3 A;  3K9M A;  3PRM A;  2GFO A;  4W4U A;  2NQI A;  2FRA A;  2AVW A;  2YJB A;  1DEU A;  2ATO A;  3HD3 A;  4XZX A;  4D8B A;  5CHV A;  4BOS A;  3N4C A;  4QBB A;  5PAD A;  4CDF B;  4QRV A;  3U8E A;  3W31 A;  3RNV A;  3F75 A;  2OUL A;  4W5C A;  1Y4H A;  2JQF R;  2YJ9 A;  4BOP A;  2DZZ A;  3KWB X;  3S3R A;  4BPV A;  4X6I A;  4D8I A;  4RY2 A;  4AXM A;  2NQD B;  3PRP A;  3H6S A;  3O65 A;  1AU2 A;  3HHI A;  1PCI A;  9PAP A;  4QRG A;  4YYU A;  2R9N A;  1PPD A;  1KFU L;  2FQ9 A; 
#chains in the Genus database with same CATH homology
 1MS6 A;  2E02 A;  2NQA A;  2DC7 A;  1PIP A;  1AU0 A;  4CDD B;  2XU5 A;  3IV2 A;  3CH3 X;  4YYV A;  2GHU A;  4K7C A;  2PBH A;  1U9X A;  4MZO A;  1F2A A;  4PP1 A;  2PAD A;  5EF4 A;  3TNX A;  2BDZ A;  3ZUA A;  3H8B A;  3OVX A;  3O1G A;  3P5W A;  2FYE A;  1F2B A;  1KFX L;  1CJL A;  3ERV A;  3O0U A;  2NQG A;  3M99 A;  3KFQ A;  1Q6K A;  3WXG A;  1CQD A;  4CDC B;  3P5X A;  2FUD A;  1YT7 A;  3V6E A;  3MOR A;  2H7J A;  2HD5 A;  3AI8 A;  6PAD A;  4CZW A;  4PI3 A;  2AS8 A;  2DZY A;  1AYV A;  1CSB B;  4BQV A;  1E2T A;  4N4Z A;  3WXF A;  5EGW A;  1AEC A;  3IHP A;  2OP3 A;  1GLO A;  2E03 A;  2O6X A;  4QRX A;  2E01 A;  4YYQ A;  2WBF X;  1NPZ A;  2YJ2 A;  3H89 A;  2HH5 A;  1QXP A;  3BOW A;  4NV7 A;  3E1Z B;  1NB5 A;  1ZCM A;  1TU6 A;  4Q8G A;  1EF7 A;  4W5B A;  3RVV A;  4MZS A;  5JH3 A;  1MHW A;  4PAD A;  1QMY A;  3LFY A;  3C9E A;  3BCN A;  2PRE A;  2F7D A;  3D6S A;  3OIS A;  2HXZ A;  2R9C A;  1S4V A;  3QSD A;  1XKG A;  2R9F A;  4FJC A;  1U9W A;  2DC9 A;  2Y6E A;  1W5R A;  2FO5 A;  1PAD A;  1F29 A;  2OZ2 A;  3OVZ A;  4AXL A;  2IBI A;  2AUX A;  2VFB A;  1MDW A;  2R9M A;  4YYW A;  5CHT A;  1EWM A;  3BPF A;  1PBH A;  2VFC A;  3OF8 A;  3MHH A;  1EWP A;  3IOQ A;  1TL9 A;  1ATK A;  2CB5 A;  3QJ3 A;  2R9O A;  5CVM A;  2ACT A;  2G7Y A;  1VSN A;  3MHS A;  2PNS A;  1AYW A;  2R6N A;  1VJV A;  3LXS A;  1CTE A;  4DMY A;  1GX3 A;  1HUC B;  3BC3 A;  2G8J A;  1EWL A;  5A24 A;  1PE6 A;  2E00 A;  7PCK A;  1U9Q X;  4X6H A;  1U9V A;  1AYU A;  2AYO A;  3IUT A;  1Y08 A;  1NQC A;  1MIR A;  4OEL A;  1M6D A;  4N79 A;  2BSZ A;  3PBH A;  4FIP A;  1MEM A;  1BGO A;  3DF0 A;  1DF0 A;  4CDE B;  2B1M A;  1BP4 A;  1JQP A;  5CVO B;  3BPM A;  3H7D A;  4Q8H A;  1AU3 A;  1POP A;  1BQI A;  3N3K A;  4XUI A;  1GEC E;  3K24 A;  4X6J A;  5CVN B;  3K8U A;  3B79 A;  2JQG R;  2FRQ A;  2XU1 A;  3PDF A;  1NL6 A;  2DJG B;  3LTW A;  4BSQ A;  2P7U A;  1CVZ A;  3WXE A;  3KKU A;  3KW9 A;  1MEG A;  1NLJ A;  4WA6 A;  2DCA A;  3HWN A;  3QT4 A;  5F02 A;  3KX1 A;  4BS6 A;  3I3T A;  2P86 A;  1KHQ A;  1IWD A;  3OF9 A;  2YJC A;  4KLB A;  1GMY A;  2DC6 A;  3KSE A;  4C5P A;  1W6F A;  3NHE A;  3P5U A;  2FTD A;  1CPJ A;  1KXR A;  2CIO A;  4QH6 A;  2XU3 A;  4OEM A;  2DCD A;  1EWO A;  1YK8 A;  1PPO A;  2VHS A;  3CH2 X;  2G6D A;  1GCB A;  1O0E A;  1K3B B;  4PP2 E;  2B1N A;  3D9W A;  1ICF A;  1PXV A;  4FK5 A;  2AYN A;  3KWZ A;  4BGF A;  3BWK A;  3IMA A;  3RVX A;  1ITO A;  4N8W A;  5FPW A;  2AU1 A;  1PPP A;  1CB5 A;  3GCB A;  4YYS A;  1SP4 B;  4XR7 A;  1X9Y A;  4HWY A;  5JA7 A;  2F1G A;  1PPN A;  2P0R A;  2G8E A;  8PCH A;  2XU4 A;  3S3Q A;  3N3G A;  1TLO A;  1U5I A;  1ZIV A;  4NV8 A;  1KHP A;  4I05 A;  2BDL A;  2IPP B;  5K16 A;  1W4T A;  4I04 A;  3CBJ A;  1CS8 A;  2AUZ A;  3IEJ A;  2C0Y A;  1AU4 A;  4BS5 A;  4P6E A;  4G54 A;  1FH0 A;  1YVB A;  2DC8 A;  2DJF B;  3MTN A;  3USV A;  4B55 A;  4MSX A;  3HHA A;  1STF E;  4P6G A;  2YJ8 A;  5J94 A;  2ARY A;  1BY8 A;  3RVW A;  2Y5B A;  4DMX A;  2HHN A;  1CV8 A;  4ZUX U;  3I06 A;  4YYR A;  1QDQ A;  3CBK A;  2DCB A;  4YVA A;  3H8C A;  3PNR A;  1AIM A;  3PW3 A;  2AIM A;  1ME4 A;  2VHF A;  4GUZ A;  2FT2 A;  1THE A;  1A6R A;  1NB3 A;  1YK7 A;  1YAL A;  3F5V A;  1SNK A;  1F2C A;  3V6C A;  2DCC A;  3P5V A;  4I07 A;  1QOL A;  4YV8 A;  1ME3 A;  3K9M A;  2GFO A;  4W4U A;  2NQI A;  2FRA A;  2AVW A;  2YJB A;  1DEU A;  2ATO A;  3HD3 A;  5CHV A;  3N4C A;  4QBB A;  5PAD A;  4CDF B;  4QRV A;  3U8E A;  3F75 A;  2OUL A;  4W5C A;  1Y4H A;  2JQF R;  2YJ9 A;  2DZZ A;  3KWB X;  3S3R A;  4BPV A;  4X6I A;  4RY2 A;  4AXM A;  2NQD B;  3H6S A;  1AU2 A;  3HHI A;  1PCI A;  9PAP A;  4QRG A;  4YYU A;  2R9N A;  1PPD A;  1KFU L;  2FQ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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