1ME3A

High resolution crystal structure analysis of cruzain non-covalently bound to a hydroxymethyl ketone inhibitor (ii)
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma cruzi
molecule keywords Cruzipain
total genus 63
structure length 215
sequence length 215
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2002-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1me3A00
1KFXL 5EGWA 4OELA 1MIRA 4X6IA 4QRVA 1KXRA 4MZOA 3H6SA 1ICFA 2F1GA 2NQAA 3F5VA 3QSDA 4P6GA 3N3GA 3CBJA 4Q8HA 1MEGA 3PBHA 1ZIVA 3H7DA 2FRQA 3WXGA 2GHUA 3KFQA 2FTDA 2E03A 1Y08A 5A24A 2YJ9A 2GFOA 2VHFA 4BPVA 4YYVA 8PCHA 3RVVA 3N4CA 1KHPA 2XU5A 1NB3A 2NQGA 3K8UA 1CJLA 1X9YA 2AVWA 3E1ZB 3PW3A 1QOLA 1NPZA 2E01A 1TL9A 3V6CA 4I05A 4DMYA 3IUTA 2XU4A 2C0YA 1A6RA 1QDQA 3OF9A 4P6EA 5F02A 2B1NA 2DC9A 2FQ9A 3DF0A 2ATOA 1TU6A 3V6EA 2HHNA 3U8EA 2CIOA 1GLOA 1PE6A 4W5CA 2G7YA 1CV8A 2Y5BA 1NLJA 1GECE 4PP1A 1SP4B 3BCNA 1AYVA 5EF4A 1Y4HA 2H7JA 2ARYA 1EWPA 2HH5A 4AXMA 3GCBA 1F29A 3KW9A 2AUZA 1GMYA 2DCAA 3D6SA 1AU4A 3OVZA 2O6XA 3RVXA 4QH6A 6PADA 3CH2X 2AIMA 1PPOA 3KKUA 3C9EA 2G8EA 2P0RA 4CDFB 1THEA 2ACTA 1F2CA 2R6NA 3NHEA 1NQCA 3P5WA 3WXFA 2PNSA 1ZCMA 3H8BA 2PADA 1AU0A 1U9VA 1YVBA 2G6DA 4HWYA 3IMAA 3LXSA 4FK5A 1AYWA 5JH3A 2PBHA 3K24A 2HXZA 5PADA 2OP3A 4XUIA 3MHSA 3P5XA 2WBFX 2E02A 4MSXA 1Q6KA 1AECA 4K7CA 3KWZA 4W4UA 4MZSA 2AU1A 1PPNA 1K3BB 1NB5A 3BPMA 1YT7A 1MDWA 1CVZA 1U9WA 3RVWA 1BP4A 2FUDA 4N4ZA 1HUCB 3MHHA 3IV2A 2VHSA 1TLOA 1FH0A 2HD5A 2YJ2A 4QRXA 4OEMA 4YYSA 2YJ8A 3MORA 4DMXA 1CTEA 2YJCA 4BQVA 2BDLA 4YYWA 3IEJA 4BS5A 3WXEA 1VSNA 2G8JA 1IWDA 5CHVA 1BQIA 3AI8A 3H89A 2JQFR 1AYUA 1JQPA 2DC8A 4KLBA 4W5BA 3F75A 5JA7A 3O1GA 1AIMA 3CBKA 2FO5A 4BSQA 2AUXA 2AYOA 2OZ2A 2E00A 5CVNB 1DF0A 1CPJA 1PADA 3S3RA 5K16A 2DC6A 4RY2A 1BGOA 1CB5A 2XU1A 3P5VA 2P7UA 1AU2A 2R9NA 4CDDB 3KX1A 1F2AA 1PXVA 2DC7A 2NQDB 3IOQA 2PREA 4I04A 4YYRA 2P86A 2YJBA 3QJ3A 3BPFA 1POPA 2DZYA 1EWMA 4CDEB 2JQGR 3M99A 1EWLA 1PPPA 1BY8A 1MEMA 3ERVA 1PIPA 2R9CA 5CVOB 1U5IA 2R9MA 2XU3A 1YK7A 1CSBB 5CHTA 3HD3A 2IBIA 1M6DA 4QRGA 3BWKA 1AU3A 3HWNA 1KFUL 4BS6A 1VJVA 3P5UA 2IPPB 4N8WA 1U9QX 4YYUA 4X6HA 4Q8GA 4PP2E 3LFYA 3B79A 2B1MA 3BC3A 2DJFB 1S4VA 4G54A 1PPDA 4YV8A 2FT2A 4AXLA 1QXPA 2FRAA 2DCDA 1F2BA 1EF7A 1O0EA 3USVA 2Y6EA 1GCBA 1PCIA 3S3QA 4X6JA 2BDZA 1STFE 1PBHA 1ME3A 3BOWA 4QBBA 4XR7A 2R9FA 2AS8A 3OVXA 1ME4A 4N79A 4FJCA 3I06A 4I07A 1XKGA 3IHPA 4YVAA 3N3KA 1MS6A 1KHQA 1YALA 4CZWA 3CH3X 3PNRA 4CDCB 1NL6A 5FPWA 3PDFA 2FYEA 1SNKA 4YYQA 2DJGB 3HHIA 7PCKA 3OF8A 2CB5A 3KSEA 1QMYA 2DZZA 4PADA 3QT4A 1CQDA 2DCCA 3OISA 5CVMA 2OULA 3O0UA 3I3TA 2NQIA 9PAPA 1DEUA 1YK8A 5J94A 2AYNA 4PI3A 1ITOA 3ZUAA 4WA6A 1MHWA 4ZUXU 2F7DA 3KWBX 2R9OA 3HHAA 2DCBA 1ATKA 1CS8A 1U9XA 4FIPA 1EWOA 3K9MA 3MTNA 3TNXA 3H8CA
chains in the Genus database with same CATH superfamily
1KFXL 5EGWA 4OELA 3RNVA 1MIRA 4X6IA 4QRVA 1KXRA 3OQCA 4MZOA 3H6SA 1ICFA 4R3DA 2F1GA 2NQAA 3F5VA 1YZBA 3QSDA 4P6GA 3N3GA 3CBJA 4Q8HA 4WURA 1MEGA 3PBHA 1ZIVA 3PHUA 3H7DA 4RKXA 2BTWA 2FRQA 3WXGA 2GHUA 3KFQA 2FTDA 3O65A 2E03A 1Y08A 5A24A 2YJ9A 2GFOA 2VHFA 4BPVA 4YYVA 8PCHA 3RVVA 3N4CA 3E9SA 2J7QC 1KHPA 2XU5A 1NB3A 4IUMA 3BBAA 2NQGA 3K8UA 1CJLA 1X9YA 2AVWA 3E1ZB 3PW3A 1QOLA 4BOPA 1NPZA 2E01A 1TL9A 4BOUA 3TMPA 3V6CA 4I05A 4DMYA 3IUTA 2XU4A 2C0YA 1A6RA 1QDQA 3OF9A 4P6EA 5F02A 2B1NA 2DC9A 2FQ9A 3DF0A 2ATOA 1TU6A 3V6EA 2HHNA 3U8EA 2CIOA 1GLOA 1PE6A 4W5CA 2G7YA 1CV8A 2Y5BA 1NLJA 4MI7A 1GECE 4PP1A 1SP4B 2JRIA 3BCNA 1AYVA 5EF4A 1Y4HA 4HXDB 2H7JA 2ARYA 1EWPA 2HH5A 5EZSA 4PT5A 4AXMA 3GCBA 1F29A 3KW9A 2AGAA 2AUZA 1GMYA 2DCAA 3D6SA 1AU4A 3OVZA 2O6XA 3RVXA 4RF0A 4QH6A 2JTCA 6PADA 3CH2X 2AIMA 4D8BA 1PPOA 4OVZA 3PHXA 3KKUA 3C9EA 2G8EA 2P0RA 4CDFB 1THEA 2BTWB 2ACTA 1F2CA 2R6NA 3NHEA 1NQCA 3P5WA 3WXFA 2PNSA 1ZCMA 3H8BA 2PADA 1AU0A 1U9VA 1YVBA 2G6DA 4HWYA 3IMAA 3LXSA 2HWKA 4FK5A 1AYWA 5JH3A 2PBHA 3K24A 2HXZA 5PADA 2OP3A 4XUIA 3MHSA 3P5XA 2WBFX 2E02A 4MSXA 1Q6KA 1AECA 4BOSA 3IFUA 4K7CA 3KWZA 4W4UA 5JZEA 1UKFA 4MZSA 2AU1A 1PPNA 1K3BB 5KO3A 1NB5A 3BPMA 1YT7A 1MDWA 4P16A 1CVZA 1U9WA 3RVWA 1BP4A 2FUDA 3W31A 1DKIA 4N4ZA 2BU3A 1HUCB 3BB7A 3MHHA 3IV2A 2DOSA 2VHSA 3TRKA 1TLOA 1FH0A 4GUAA 4RNAA 2HD5A 2YJ2A 4QRXA 4OEMA 4YYSA 2YJ8A 2J7QA 3MORA 3PRPA 4DMXA 1CTEA 2YJCA 4BQVA 2BDLA 3C0RA 4YYWA 3IEJA 4BS5A 3WXEA 1VSNA 2G8JA 1IWDA 5CHVA 1BQIA 3AI8A 3H89A 2JQFR 1AYUA 1JQPA 2DC8A 4KLBA 3PHWA 4W5BA 3F75A 5JA7A 3O1GA 1AIMA 3CBKA 2FO5A 4BSQA 2AUXA 2AYOA 2OZ2A 2E00A 5CVNB 1DF0A 1CPJA 1PADA 3S3RA 5K16A 2DC6A 4D8EA 4RY2A 1BGOA 1CB5A 2XU1A 3P5VA 2P7UA 1AU2A 2R9NA 4ZTBA 3MTVA 4CDDB 3KX1A 1F2AA 5E6JA 2UZJA 1PXVA 2DC7A 2NQDB 3IOQA 2PREA 4I04A 4YYRA 3W30A 2P86A 2YJBA 3QJ3A 3BPFA 1POPA 2DZYA 1EWMA 4CDEB 2JQGR 3M99A 1EWLA 1PPPA 3MP2A 1BY8A 1MEMA 3ERVA 1PIPA 2R9CA 5CVOB 1U5IA 2R9MA 2XU3A 1YK7A 1CSBB 5CHTA 3HD3A 2IBIA 1M6DA 4QRGA 3BWKA 4RF1A 1AU3A 1PVJA 3HWNA 1KFUL 4BS6A 1VJVA 3P5UA 4M0WA 4IP3A 2IPPB 4N8WA 1U9QX 4YYUA 4X6HA 4Q8GA 4BOZA 4PP2E 3LFYA 3PSEA 3B79A 2B1MA 3B21A 3BC3A 5EZQA 2DJFB 1S4VA 4G54A 1PPDA 4A5UA 4YV8A 2FT2A 4AXLA 1QXPA 2FRAA 2DCDA 2FE8A 1F2BA 1EF7A 1O0EA 3USVA 2Y6EA 1GCBA 1PCIA 3S3QA 4X6JA 2BDZA 3BY4A 1STFE 1PBHA 1ME3A 3BOWA 4QBBA 4XR7A 2R9FA 4OW0A 2AS8A 3OVXA 1ME4A 4N79A 3PT2A 4FJCA 3I06A 4I07A 1XKGA 3IHPA 4YVAA 3N3KA 2Z84A 1MS6A 1KHQA 1YALA 4CZWA 3CH3X 3PNRA 4MM3B 4CDCB 1NL6A 5FPWA 4OVZB 3ZNHA 3PDFA 2FYEA 3PRMA 1SNKA 4YYQA 2DJGB 3HHIA 7PCKA 3OF8A 2CB5A 3KSEA 1QMYA 2DZZA 4REZA 4PADA 4BOQA 3QT4A 1CQDA 2DCCA 4D8IA 3OISA 5CVMA 2OULA 3O0UA 3I3TA 2NQIA 9PAPA 1DEUA 1YK8A 5J94A 2AYNA 4PI3A 1ITOA 3ZUAA 4WA6A 1MHWA 4ZUXU 2F7DA 3KWBX 2R9OA 3HHAA 2DCBA 1ATKA 1CS8A 4XZXA 1U9XA 4FIPA 1EWOA 3MJ5A 3K9MA 3MTNA 3TNXA 3H8CA
chains in the Genus database with same CATH topology
1KFXL 5EGWA 4OELA 1MIRA 4X6IA 4QRVA 1KXRA 4MZOA 3H6SA 1ICFA 2F1GA 2NQAA 3F5VA 3QSDA 4P6GA 3N3GA 3CBJA 4Q8HA 1MEGA 3PBHA 1ZIVA 3H7DA 2FRQA 3WXGA 2GHUA 3KFQA 2FTDA 2E03A 1Y08A 5A24A 2YJ9A 2GFOA 2VHFA 4BPVA 4YYVA 8PCHA 3RVVA 3N4CA 1GX3A 1KHPA 2XU5A 1NB3A 2NQGA 3K8UA 1CJLA 1X9YA 2AVWA 3E1ZB 3PW3A 1QOLA 1NPZA 2E01A 1TL9A 3V6CA 4I05A 4DMYA 3IUTA 2XU4A 2C0YA 1A6RA 1QDQA 3OF9A 4P6EA 5F02A 2B1NA 2DC9A 2FQ9A 3DF0A 2ATOA 1TU6A 3V6EA 2HHNA 4NV7A 3U8EA 2CIOA 1GLOA 1PE6A 4W5CA 2G7YA 1CV8A 2Y5BA 1NLJA 1GECE 4PP1A 1SP4B 3BCNA 1AYVA 5EF4A 1Y4HA 2H7JA 2ARYA 1EWPA 2HH5A 4AXMA 3GCBA 1F29A 3KW9A 2AUZA 1W5RA 1GMYA 2DCAA 3D6SA 1AU4A 3OVZA 2O6XA 3RVXA 4QH6A 6PADA 3CH2X 2AIMA 1PPOA 2VFBA 3KKUA 3C9EA 2G8EA 2P0RA 4CDFB 1THEA 2ACTA 1F2CA 2R6NA 3LTWA 3NHEA 1NQCA 3P5WA 3WXFA 2PNSA 1ZCMA 3H8BA 2PADA 1AU0A 2VFCA 1U9VA 1YVBA 2G6DA 4HWYA 3IMAA 3LXSA 4FK5A 1AYWA 5JH3A 2PBHA 3K24A 2HXZA 5PADA 2BSZA 2OP3A 4XUIA 3MHSA 3P5XA 2WBFX 2E02A 4MSXA 1Q6KA 1AECA 4K7CA 3KWZA 4W4UA 4MZSA 2AU1A 1PPNA 1K3BB 1NB5A 3BPMA 1YT7A 1MDWA 1CVZA 1U9WA 3RVWA 1BP4A 4GUZA 2FUDA 4N4ZA 1HUCB 3MHHA 3IV2A 2VHSA 1TLOA 1FH0A 2HD5A 2YJ2A 4QRXA 4OEMA 4YYSA 2YJ8A 3MORA 4DMXA 1CTEA 2YJCA 4BQVA 2BDLA 4YYWA 3IEJA 4BS5A 3WXEA 4C5PA 1VSNA 2G8JA 1IWDA 5CHVA 1BQIA 3D9WA 3AI8A 3H89A 4B55A 2JQFR 1AYUA 1JQPA 2DC8A 4KLBA 4W5BA 3F75A 5JA7A 3O1GA 1AIMA 3CBKA 2FO5A 4BSQA 2AUXA 2AYOA 2OZ2A 2E00A 5CVNB 1DF0A 1CPJA 1PADA 3S3RA 5K16A 2DC6A 4RY2A 1BGOA 1CB5A 2XU1A 3P5VA 2P7UA 1AU2A 2R9NA 1W6FA 4CDDB 3KX1A 1F2AA 1PXVA 2DC7A 2NQDB 3IOQA 2PREA 4I04A 4YYRA 2P86A 2YJBA 3QJ3A 3BPFA 1POPA 2DZYA 1EWMA 4CDEB 2JQGR 3M99A 1EWLA 1PPPA 1BY8A 1MEMA 3ERVA 1PIPA 2R9CA 5CVOB 1U5IA 2R9MA 2XU3A 1YK7A 1CSBB 5CHTA 3HD3A 2IBIA 1M6DA 4QRGA 3BWKA 1AU3A 3HWNA 1KFUL 4BS6A 1VJVA 3P5UA 2IPPB 4N8WA 1U9QX 4YYUA 4X6HA 4Q8GA 4PP2E 3LFYA 3B79A 2B1MA 3BC3A 2DJFB 1E2TA 1S4VA 4G54A 1PPDA 4YV8A 2FT2A 4AXLA 1QXPA 2FRAA 2DCDA 1F2BA 1EF7A 1O0EA 3USVA 2Y6EA 1GCBA 1PCIA 3S3QA 1W4TA 4X6JA 2BDZA 1STFE 1PBHA 1ME3A 3BOWA 4QBBA 4XR7A 2R9FA 2AS8A 3OVXA 1ME4A 4N79A 4FJCA 3I06A 4I07A 1XKGA 3IHPA 4YVAA 3N3KA 1MS6A 1KHQA 1YALA 4CZWA 3CH3X 4BGFA 3PNRA 4CDCB 1NL6A 5FPWA 3PDFA 2FYEA 1SNKA 4YYQA 2DJGB 3HHIA 7PCKA 4NV8A 3OF8A 2CB5A 3KSEA 1QMYA 2DZZA 4PADA 3QT4A 1CQDA 2DCCA 3OISA 5CVMA 2OULA 3O0UA 3I3TA 2NQIA 9PAPA 1DEUA 1YK8A 5J94A 2AYNA 4PI3A 1ITOA 3ZUAA 4WA6A 1MHWA 4ZUXU 2F7DA 3KWBX 2R9OA 3HHAA 2DCBA 1ATKA 1CS8A 1U9XA 4FIPA 1EWOA 3K9MA 3MTNA 3TNXA 3H8CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KFX L;  5EGW A;  4OEL A;  1MIR A;  4X6I A;  4QRV A;  1KXR A;  4MZO A;  3H6S A;  1ICF A;  2F1G A;  2NQA A;  3F5V A;  3QSD A;  4P6G A;  3N3G A;  3CBJ A;  4Q8H A;  1MEG A;  3PBH A;  1ZIV A;  3H7D A;  2FRQ A;  3WXG A;  2GHU A;  3KFQ A;  2FTD A;  2E03 A;  1Y08 A;  5A24 A;  2YJ9 A;  2GFO A;  2VHF A;  4BPV A;  4YYV A;  8PCH A;  3RVV A;  3N4C A;  1KHP A;  2XU5 A;  1NB3 A;  2NQG A;  3K8U A;  1CJL A;  1X9Y A;  2AVW A;  3E1Z B;  3PW3 A;  1QOL A;  1NPZ A;  2E01 A;  1TL9 A;  3V6C A;  4I05 A;  4DMY A;  3IUT A;  2XU4 A;  2C0Y A;  1A6R A;  1QDQ A;  3OF9 A;  4P6E A;  5F02 A;  2B1N A;  2DC9 A;  2FQ9 A;  3DF0 A;  2ATO A;  1TU6 A;  3V6E A;  2HHN A;  3U8E A;  2CIO A;  1GLO A;  1PE6 A;  4W5C A;  2G7Y A;  1CV8 A;  2Y5B A;  1NLJ A;  1GEC E;  4PP1 A;  1SP4 B;  3BCN A;  1AYV A;  5EF4 A;  1Y4H A;  2H7J A;  2ARY A;  1EWP A;  2HH5 A;  4AXM A;  3GCB A;  1F29 A;  3KW9 A;  2AUZ A;  1GMY A;  2DCA A;  3D6S A;  1AU4 A;  3OVZ A;  2O6X A;  3RVX A;  4QH6 A;  6PAD A;  3CH2 X;  2AIM A;  1PPO A;  3KKU A;  3C9E A;  2G8E A;  2P0R A;  4CDF B;  1THE A;  2ACT A;  1F2C A;  2R6N A;  3NHE A;  1NQC A;  3P5W A;  3WXF A;  2PNS A;  1ZCM A;  3H8B A;  2PAD A;  1AU0 A;  1U9V A;  1YVB A;  2G6D A;  4HWY A;  3IMA A;  3LXS A;  4FK5 A;  1AYW A;  5JH3 A;  2PBH A;  3K24 A;  2HXZ A;  5PAD A;  2OP3 A;  4XUI A;  3MHS A;  3P5X A;  2WBF X;  2E02 A;  4MSX A;  1Q6K A;  1AEC A;  4K7C A;  3KWZ A;  4W4U A;  4MZS A;  2AU1 A;  1PPN A;  1K3B B;  1NB5 A;  3BPM A;  1YT7 A;  1MDW A;  1CVZ A;  1U9W A;  3RVW A;  1BP4 A;  2FUD A;  4N4Z A;  1HUC B;  3MHH A;  3IV2 A;  2VHS A;  1TLO A;  1FH0 A;  2HD5 A;  2YJ2 A;  4QRX A;  4OEM A;  4YYS A;  2YJ8 A;  3MOR A;  4DMX A;  1CTE A;  2YJC A;  4BQV A;  2BDL A;  4YYW A;  3IEJ A;  4BS5 A;  3WXE A;  1VSN A;  2G8J A;  1IWD A;  5CHV A;  1BQI A;  3AI8 A;  3H89 A;  2JQF R;  1AYU A;  1JQP A;  2DC8 A;  4KLB A;  4W5B A;  3F75 A;  5JA7 A;  3O1G A;  1AIM A;  3CBK A;  2FO5 A;  4BSQ A;  2AUX A;  2AYO A;  2OZ2 A;  2E00 A;  5CVN B;  1DF0 A;  1CPJ A;  1PAD A;  3S3R A;  5K16 A;  2DC6 A;  4RY2 A;  1BGO A;  1CB5 A;  2XU1 A;  3P5V A;  2P7U A;  1AU2 A;  2R9N A;  4CDD B;  3KX1 A;  1F2A A;  1PXV A;  2DC7 A;  2NQD B;  3IOQ A;  2PRE A;  4I04 A;  4YYR A;  2P86 A;  2YJB A;  3QJ3 A;  3BPF A;  1POP A;  2DZY A;  1EWM A;  4CDE B;  2JQG R;  3M99 A;  1EWL A;  1PPP A;  1BY8 A;  1MEM A;  3ERV A;  1PIP A;  2R9C A;  5CVO B;  1U5I A;  2R9M A;  2XU3 A;  1YK7 A;  1CSB B;  5CHT A;  3HD3 A;  2IBI A;  1M6D A;  4QRG A;  3BWK A;  1AU3 A;  3HWN A;  1KFU L;  4BS6 A;  1VJV A;  3P5U A;  2IPP B;  4N8W A;  1U9Q X;  4YYU A;  4X6H A;  4Q8G A;  4PP2 E;  3LFY A;  3B79 A;  2B1M A;  3BC3 A;  2DJF B;  1S4V A;  4G54 A;  1PPD A;  4YV8 A;  2FT2 A;  4AXL A;  1QXP A;  2FRA A;  2DCD A;  1F2B A;  1EF7 A;  1O0E A;  3USV A;  2Y6E A;  1GCB A;  1PCI A;  3S3Q A;  4X6J A;  2BDZ A;  1STF E;  1PBH A;  1ME3 A;  3BOW A;  4QBB A;  4XR7 A;  2R9F A;  2AS8 A;  3OVX A;  1ME4 A;  4N79 A;  4FJC A;  3I06 A;  4I07 A;  1XKG A;  3IHP A;  4YVA A;  3N3K A;  1MS6 A;  1KHQ A;  1YAL A;  4CZW A;  3CH3 X;  3PNR A;  4CDC B;  1NL6 A;  5FPW A;  3PDF A;  2FYE A;  1SNK A;  4YYQ A;  2DJG B;  3HHI A;  7PCK A;  3OF8 A;  2CB5 A;  3KSE A;  1QMY A;  2DZZ A;  4PAD A;  3QT4 A;  1CQD A;  2DCC A;  3OIS A;  5CVM A;  2OUL A;  3O0U A;  3I3T A;  2NQI A;  9PAP A;  1DEU A;  1YK8 A;  5J94 A;  2AYN A;  4PI3 A;  1ITO A;  3ZUA A;  4WA6 A;  1MHW A;  4ZUX U;  2F7D A;  3KWB X;  2R9O A;  3HHA A;  2DCB A;  1ATK A;  1CS8 A;  1U9X A;  4FIP A;  1EWO A;  3K9M A;  3MTN A;  3TNX A;  3H8C A; 
#chains in the Genus database with same CATH topology
 1KFX L;  5EGW A;  4OEL A;  3RNV A;  1MIR A;  4X6I A;  4QRV A;  1KXR A;  3OQC A;  4MZO A;  3H6S A;  1ICF A;  4R3D A;  2F1G A;  2NQA A;  3F5V A;  1YZB A;  3QSD A;  4P6G A;  3N3G A;  3CBJ A;  4Q8H A;  4WUR A;  1MEG A;  3PBH A;  1ZIV A;  3PHU A;  3H7D A;  4RKX A;  2BTW A;  2FRQ A;  3WXG A;  2GHU A;  3KFQ A;  2FTD A;  3O65 A;  2E03 A;  1Y08 A;  5A24 A;  2YJ9 A;  2GFO A;  2VHF A;  4BPV A;  4YYV A;  8PCH A;  3RVV A;  3N4C A;  3E9S A;  2J7Q C;  1KHP A;  2XU5 A;  1NB3 A;  4IUM A;  3BBA A;  2NQG A;  3K8U A;  1CJL A;  1X9Y A;  2AVW A;  3E1Z B;  3PW3 A;  1QOL A;  4BOP A;  1NPZ A;  2E01 A;  1TL9 A;  4BOU A;  3TMP A;  3V6C A;  4I05 A;  4DMY A;  3IUT A;  2XU4 A;  2C0Y A;  1A6R A;  1QDQ A;  3OF9 A;  4P6E A;  5F02 A;  2B1N A;  2DC9 A;  2FQ9 A;  3DF0 A;  2ATO A;  1TU6 A;  3V6E A;  2HHN A;  3U8E A;  2CIO A;  1GLO A;  1PE6 A;  4W5C A;  2G7Y A;  1CV8 A;  2Y5B A;  1NLJ A;  4MI7 A;  1GEC E;  4PP1 A;  1SP4 B;  2JRI A;  3BCN A;  1AYV A;  5EF4 A;  1Y4H A;  4HXD B;  2H7J A;  2ARY A;  1EWP A;  2HH5 A;  5EZS A;  4PT5 A;  4AXM A;  3GCB A;  1F29 A;  3KW9 A;  2AGA A;  2AUZ A;  1GMY A;  2DCA A;  3D6S A;  1AU4 A;  3OVZ A;  2O6X A;  3RVX A;  4RF0 A;  4QH6 A;  2JTC A;  6PAD A;  3CH2 X;  2AIM A;  4D8B A;  1PPO A;  4OVZ A;  3PHX A;  3KKU A;  3C9E A;  2G8E A;  2P0R A;  4CDF B;  1THE A;  2BTW B;  2ACT A;  1F2C A;  2R6N A;  3NHE A;  1NQC A;  3P5W A;  3WXF A;  2PNS A;  1ZCM A;  3H8B A;  2PAD A;  1AU0 A;  1U9V A;  1YVB A;  2G6D A;  4HWY A;  3IMA A;  3LXS A;  2HWK A;  4FK5 A;  1AYW A;  5JH3 A;  2PBH A;  3K24 A;  2HXZ A;  5PAD A;  2OP3 A;  4XUI A;  3MHS A;  3P5X A;  2WBF X;  2E02 A;  4MSX A;  1Q6K A;  1AEC A;  4BOS A;  3IFU A;  4K7C A;  3KWZ A;  4W4U A;  5JZE A;  1UKF A;  4MZS A;  2AU1 A;  1PPN A;  1K3B B;  5KO3 A;  1NB5 A;  3BPM A;  1YT7 A;  1MDW A;  4P16 A;  1CVZ A;  1U9W A;  3RVW A;  1BP4 A;  2FUD A;  3W31 A;  1DKI A;  4N4Z A;  2BU3 A;  1HUC B;  3BB7 A;  3MHH A;  3IV2 A;  2DOS A;  2VHS A;  3TRK A;  1TLO A;  1FH0 A;  4GUA A;  4RNA A;  2HD5 A;  2YJ2 A;  4QRX A;  4OEM A;  4YYS A;  2YJ8 A;  2J7Q A;  3MOR A;  3PRP A;  4DMX A;  1CTE A;  2YJC A;  4BQV A;  2BDL A;  3C0R A;  4YYW A;  3IEJ A;  4BS5 A;  3WXE A;  1VSN A;  2G8J A;  1IWD A;  5CHV A;  1BQI A;  3AI8 A;  3H89 A;  2JQF R;  1AYU A;  1JQP A;  2DC8 A;  4KLB A;  3PHW A;  4W5B A;  3F75 A;  5JA7 A;  3O1G A;  1AIM A;  3CBK A;  2FO5 A;  4BSQ A;  2AUX A;  2AYO A;  2OZ2 A;  2E00 A;  5CVN B;  1DF0 A;  1CPJ A;  1PAD A;  3S3R A;  5K16 A;  2DC6 A;  4D8E A;  4RY2 A;  1BGO A;  1CB5 A;  2XU1 A;  3P5V A;  2P7U A;  1AU2 A;  2R9N A;  4ZTB A;  3MTV A;  4CDD B;  3KX1 A;  1F2A A;  5E6J A;  2UZJ A;  1PXV A;  2DC7 A;  2NQD B;  3IOQ A;  2PRE A;  4I04 A;  4YYR A;  3W30 A;  2P86 A;  2YJB A;  3QJ3 A;  3BPF A;  1POP A;  2DZY A;  1EWM A;  4CDE B;  2JQG R;  3M99 A;  1EWL A;  1PPP A;  3MP2 A;  1BY8 A;  1MEM A;  3ERV A;  1PIP A;  2R9C A;  5CVO B;  1U5I A;  2R9M A;  2XU3 A;  1YK7 A;  1CSB B;  5CHT A;  3HD3 A;  2IBI A;  1M6D A;  4QRG A;  3BWK A;  4RF1 A;  1AU3 A;  1PVJ A;  3HWN A;  1KFU L;  4BS6 A;  1VJV A;  3P5U A;  4M0W A;  4IP3 A;  2IPP B;  4N8W A;  1U9Q X;  4YYU A;  4X6H A;  4Q8G A;  4BOZ A;  4PP2 E;  3LFY A;  3PSE A;  3B79 A;  2B1M A;  3B21 A;  3BC3 A;  5EZQ A;  2DJF B;  1S4V A;  4G54 A;  1PPD A;  4A5U A;  4YV8 A;  2FT2 A;  4AXL A;  1QXP A;  2FRA A;  2DCD A;  2FE8 A;  1F2B A;  1EF7 A;  1O0E A;  3USV A;  2Y6E A;  1GCB A;  1PCI A;  3S3Q A;  4X6J A;  2BDZ A;  3BY4 A;  1STF E;  1PBH A;  1ME3 A;  3BOW A;  4QBB A;  4XR7 A;  2R9F A;  4OW0 A;  2AS8 A;  3OVX A;  1ME4 A;  4N79 A;  3PT2 A;  4FJC A;  3I06 A;  4I07 A;  1XKG A;  3IHP A;  4YVA A;  3N3K A;  2Z84 A;  1MS6 A;  1KHQ A;  1YAL A;  4CZW A;  3CH3 X;  3PNR A;  4MM3 B;  4CDC B;  1NL6 A;  5FPW A;  4OVZ B;  3ZNH A;  3PDF A;  2FYE A;  3PRM A;  1SNK A;  4YYQ A;  2DJG B;  3HHI A;  7PCK A;  3OF8 A;  2CB5 A;  3KSE A;  1QMY A;  2DZZ A;  4REZ A;  4PAD A;  4BOQ A;  3QT4 A;  1CQD A;  2DCC A;  4D8I A;  3OIS A;  5CVM A;  2OUL A;  3O0U A;  3I3T A;  2NQI A;  9PAP A;  1DEU A;  1YK8 A;  5J94 A;  2AYN A;  4PI3 A;  1ITO A;  3ZUA A;  4WA6 A;  1MHW A;  4ZUX U;  2F7D A;  3KWB X;  2R9O A;  3HHA A;  2DCB A;  1ATK A;  1CS8 A;  4XZX A;  1U9X A;  4FIP A;  1EWO A;  3MJ5 A;  3K9M A;  3MTN A;  3TNX A;  3H8C A; 
#chains in the Genus database with same CATH homology
 1KFX L;  5EGW A;  4OEL A;  1MIR A;  4X6I A;  4QRV A;  1KXR A;  4MZO A;  3H6S A;  1ICF A;  2F1G A;  2NQA A;  3F5V A;  3QSD A;  4P6G A;  3N3G A;  3CBJ A;  4Q8H A;  1MEG A;  3PBH A;  1ZIV A;  3H7D A;  2FRQ A;  3WXG A;  2GHU A;  3KFQ A;  2FTD A;  2E03 A;  1Y08 A;  5A24 A;  2YJ9 A;  2GFO A;  2VHF A;  4BPV A;  4YYV A;  8PCH A;  3RVV A;  3N4C A;  1GX3 A;  1KHP A;  2XU5 A;  1NB3 A;  2NQG A;  3K8U A;  1CJL A;  1X9Y A;  2AVW A;  3E1Z B;  3PW3 A;  1QOL A;  1NPZ A;  2E01 A;  1TL9 A;  3V6C A;  4I05 A;  4DMY A;  3IUT A;  2XU4 A;  2C0Y A;  1A6R A;  1QDQ A;  3OF9 A;  4P6E A;  5F02 A;  2B1N A;  2DC9 A;  2FQ9 A;  3DF0 A;  2ATO A;  1TU6 A;  3V6E A;  2HHN A;  4NV7 A;  3U8E A;  2CIO A;  1GLO A;  1PE6 A;  4W5C A;  2G7Y A;  1CV8 A;  2Y5B A;  1NLJ A;  1GEC E;  4PP1 A;  1SP4 B;  3BCN A;  1AYV A;  5EF4 A;  1Y4H A;  2H7J A;  2ARY A;  1EWP A;  2HH5 A;  4AXM A;  3GCB A;  1F29 A;  3KW9 A;  2AUZ A;  1W5R A;  1GMY A;  2DCA A;  3D6S A;  1AU4 A;  3OVZ A;  2O6X A;  3RVX A;  4QH6 A;  6PAD A;  3CH2 X;  2AIM A;  1PPO A;  2VFB A;  3KKU A;  3C9E A;  2G8E A;  2P0R A;  4CDF B;  1THE A;  2ACT A;  1F2C A;  2R6N A;  3LTW A;  3NHE A;  1NQC A;  3P5W A;  3WXF A;  2PNS A;  1ZCM A;  3H8B A;  2PAD A;  1AU0 A;  2VFC A;  1U9V A;  1YVB A;  2G6D A;  4HWY A;  3IMA A;  3LXS A;  4FK5 A;  1AYW A;  5JH3 A;  2PBH A;  3K24 A;  2HXZ A;  5PAD A;  2BSZ A;  2OP3 A;  4XUI A;  3MHS A;  3P5X A;  2WBF X;  2E02 A;  4MSX A;  1Q6K A;  1AEC A;  4K7C A;  3KWZ A;  4W4U A;  4MZS A;  2AU1 A;  1PPN A;  1K3B B;  1NB5 A;  3BPM A;  1YT7 A;  1MDW A;  1CVZ A;  1U9W A;  3RVW A;  1BP4 A;  4GUZ A;  2FUD A;  4N4Z A;  1HUC B;  3MHH A;  3IV2 A;  2VHS A;  1TLO A;  1FH0 A;  2HD5 A;  2YJ2 A;  4QRX A;  4OEM A;  4YYS A;  2YJ8 A;  3MOR A;  4DMX A;  1CTE A;  2YJC A;  4BQV A;  2BDL A;  4YYW A;  3IEJ A;  4BS5 A;  3WXE A;  4C5P A;  1VSN A;  2G8J A;  1IWD A;  5CHV A;  1BQI A;  3D9W A;  3AI8 A;  3H89 A;  4B55 A;  2JQF R;  1AYU A;  1JQP A;  2DC8 A;  4KLB A;  4W5B A;  3F75 A;  5JA7 A;  3O1G A;  1AIM A;  3CBK A;  2FO5 A;  4BSQ A;  2AUX A;  2AYO A;  2OZ2 A;  2E00 A;  5CVN B;  1DF0 A;  1CPJ A;  1PAD A;  3S3R A;  5K16 A;  2DC6 A;  4RY2 A;  1BGO A;  1CB5 A;  2XU1 A;  3P5V A;  2P7U A;  1AU2 A;  2R9N A;  1W6F A;  4CDD B;  3KX1 A;  1F2A A;  1PXV A;  2DC7 A;  2NQD B;  3IOQ A;  2PRE A;  4I04 A;  4YYR A;  2P86 A;  2YJB A;  3QJ3 A;  3BPF A;  1POP A;  2DZY A;  1EWM A;  4CDE B;  2JQG R;  3M99 A;  1EWL A;  1PPP A;  1BY8 A;  1MEM A;  3ERV A;  1PIP A;  2R9C A;  5CVO B;  1U5I A;  2R9M A;  2XU3 A;  1YK7 A;  1CSB B;  5CHT A;  3HD3 A;  2IBI A;  1M6D A;  4QRG A;  3BWK A;  1AU3 A;  3HWN A;  1KFU L;  4BS6 A;  1VJV A;  3P5U A;  2IPP B;  4N8W A;  1U9Q X;  4YYU A;  4X6H A;  4Q8G A;  4PP2 E;  3LFY A;  3B79 A;  2B1M A;  3BC3 A;  2DJF B;  1E2T A;  1S4V A;  4G54 A;  1PPD A;  4YV8 A;  2FT2 A;  4AXL A;  1QXP A;  2FRA A;  2DCD A;  1F2B A;  1EF7 A;  1O0E A;  3USV A;  2Y6E A;  1GCB A;  1PCI A;  3S3Q A;  1W4T A;  4X6J A;  2BDZ A;  1STF E;  1PBH A;  1ME3 A;  3BOW A;  4QBB A;  4XR7 A;  2R9F A;  2AS8 A;  3OVX A;  1ME4 A;  4N79 A;  4FJC A;  3I06 A;  4I07 A;  1XKG A;  3IHP A;  4YVA A;  3N3K A;  1MS6 A;  1KHQ A;  1YAL A;  4CZW A;  3CH3 X;  4BGF A;  3PNR A;  4CDC B;  1NL6 A;  5FPW A;  3PDF A;  2FYE A;  1SNK A;  4YYQ A;  2DJG B;  3HHI A;  7PCK A;  4NV8 A;  3OF8 A;  2CB5 A;  3KSE A;  1QMY A;  2DZZ A;  4PAD A;  3QT4 A;  1CQD A;  2DCC A;  3OIS A;  5CVM A;  2OUL A;  3O0U A;  3I3T A;  2NQI A;  9PAP A;  1DEU A;  1YK8 A;  5J94 A;  2AYN A;  4PI3 A;  1ITO A;  3ZUA A;  4WA6 A;  1MHW A;  4ZUX U;  2F7D A;  3KWB X;  2R9O A;  3HHA A;  2DCB A;  1ATK A;  1CS8 A;  1U9X A;  4FIP A;  1EWO A;  3K9M A;  3MTN A;  3TNX A;  3H8C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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