4D8EA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8eA00
4D8EA 3BB7A 1PVJA 4D8IA 2JTCA 1DKIA 2UZJA 3BBAA 4D8BA 4RKXA
chains in the Genus database with same CATH superfamily
3W30A 2NQGA 5EZQA 1QXPA 2P7UA 5K16A 5EGWA 2E03A 1AU2A 1CV8A 3B79A 3IOQA 1U9VA 2R9FA 7PCKA 3OISA 2G8EA 2R9CA 2AU1A 1NL6A 4IP3A 3IHPA 2NQIA 5KO3A 4Q8GA 2E02A 4BQVA 1NPZA 1F2CA 2HWKA 1PXVA 2F7DA 1NLJA 2HH5A 1F29A 4YYRA 4RNAA 2HD5A 1F2AA 4OW0A 3BB7A 1EWPA 1Y4HA 2DCBA 4MSXA 3K24A 2FE8A 2FRQA 2IBIA 3BWKA 4P6GA 1THEA 2BDZA 1CB5A 4K7CA 4W4UA 1AYUA 2YJ2A 1VSNA 3RNVA 1MS6A 3H8CA 4CDFB 2OZ2A 2R9OA 2B1MA 2Y6EA 1NB3A 1AYVA 3O1GA 4HWYA 2NQDB 1O0EA 4P6EA 3MHSA 1SNKA 1PE6A 3PRMA 4N8WA 3KFQA 4W5CA 1PCIA 4P16A 4DMXA 3PNRA 5EF4A 1CJLA 3AI8A 4XR7A 5F02A 2E00A 1MEMA 2FTDA 1KHQA 4YYVA 1YVBA 1DKIA 2FO5A 4BOPA 3KKUA 3V6EA 1YK8A 3QT4A 3PT2A 4RKXA 2FT2A 3MORA 3NHEA 5CHVA 5JZEA 4OVZB 1PPPA 2JRIA 1S4VA 4D8EA 3F75A 4A5UA 1YK7A 3BY4A 3CH3X 3OVXA 4YVAA 2FYEA 1CPJA 4CDEB 1CS8A 2ARYA 2AUXA 3HD3A 3TRKA 1ME3A 1ZCMA 4RF0A 1PIPA 1ITOA 2ACTA 2PADA 1X9YA 2ATOA 2J7QC 2Z84A 4PADA 1CQDA 1HUCB 2Y5BA 3P5XA 1QDQA 3PDFA 3H6SA 1MHWA 3OQCA 1MIRA 3WXFA 4MZSA 2FRAA 1QMYA 1TLOA 2BU3A 2G6DA 2JQFR 1SP4B 2JTCA 1K3BB 1MEGA 1F2BA 2H7JA 3D6SA 4OELA 3IMAA 2PREA 3HWNA 1Q6KA 3BCNA 1XKGA 2YJ9A 1PADA 8PCHA 3MHHA 1PPDA 3IV2A 1EF7A 5JH3A 3U8EA 1A6RA 2DC7A 4AXLA 4YYSA 3QSDA 2R9NA 5A24A 1PPOA 1DEUA 3PHUA 3ZUAA 2AYNA 4QBBA 4N4ZA 3MP2A 2VHSA 3GCBA 3K9MA 1YZBA 1NB5A 3BBAA 4ZTBA 3KW9A 3O65A 2BTWB 4I05A 3KWZA 3CBKA 1NQCA 4CDDB 2G8JA 4BPVA 5CVOB 5CHTA 3TMPA 4RF1A 1AU0A 3PW3A 3CH2X 1BY8A 1BGOA 4M0WA 2G7YA 2C0YA 1UKFA 3PHXA 2CB5A 4N79A 4RY2A 3B21A 4D8BA 3IFUA 1U5IA 2B1NA 1PBHA 2DCCA 4HXDB 4I07A 1PVJA 2FUDA 1GLOA 3PSEA 3N4CA 2P86A 2R6NA 1EWOA 1KFXL 1STFE 4I04A 4BOUA 2DJFB 4YYQA 3I3TA 2IPPB 1JQPA 2DCDA 2VHFA 3V6CA 2XU4A 3E1ZB 3PRPA 1YALA 2OP3A 3USVA 2O6XA 2AVWA 4D8IA 3KSEA 4YYWA 2R9MA 2DC9A 2XU1A 4G54A 3LXSA 4CDCB 3KWBX 4YV8A 4ZUXU 4MM3B 3IEJA 5E6JA 3S3QA 3WXGA 1AU3A 1EWMA 3MTVA 2DJGB 2AYOA 3K8UA 1TU6A 1ATKA 1DF0A 2AGAA 3DF0A 4FK5A 2DC8A 3OF8A 3H8BA 4X6HA 3N3KA 2XU3A 3C9EA 1AIMA 1AECA 2YJ8A 5CVMA 3C0RA 3O0UA 3KX1A 1ICFA 4PT5A 2YJBA 4AXMA 1AYWA 4XZXA 4QH6A 5CVNB 3HHIA 2GFOA 1EWLA 3MTNA 2BDLA 4KLBA 2DZYA 3RVXA 4MI7A 2DZZA 1BQIA 4REZA 3I06A 4QRXA 5JA7A 1PPNA 4X6JA 1POPA 2AIMA 4YYUA 3P5WA 5J94A 1U9WA 3HHAA 3LFYA 3P5VA 4Q8HA 3CBJA 4PP2E 2DOSA 1VJVA 3W31A 4QRVA 3H7DA 3OVZA 1CVZA 3P5UA 4MZOA 1CSBB 5PADA 1IWDA 4FJCA 2AS8A 2P0RA 1CTEA 3F5VA 4PP1A 4GUAA 2XU5A 3RVWA 4BS6A 4WURA 1AU4A 1YT7A 2DC6A 1M6DA 2UZJA 3RVVA 2J7QA 3M99A 3WXEA 1KXRA 2NQAA 4BOZA 2BTWA 2OULA 2E01A 1KFUL 2FQ9A 4BOSA 4BS5A 2F1GA 4CZWA 1QOLA 3H89A 4PI3A 4IUMA 3N3GA 1U9QX 2WBFX 4BOQA 3BC3A 2AUZA 3TNXA 1ME4A 1ZIVA 1TL9A 1U9XA 4XUIA 2DCAA 3E9SA 4DMYA 4BSQA 4X6IA 3QJ3A 2JQGR 3IUTA 3ERVA 6PADA 4QRGA 4W5BA 2YJCA 1BP4A 5EZSA 1GMYA 4R3DA 2CIOA 2HXZA 3MJ5A 4WA6A 1GECE 2PBHA 5FPWA 1KHPA 3ZNHA 3BPFA 1MDWA 4OVZA 3BOWA 1GCBA 1Y08A 1FH0A 3OF9A 4OEMA 3BPMA 3PBHA 9PAPA 3S3RA 2GHUA 4FIPA 2HHNA 2PNSA 3PHWA
chains in the Genus database with same CATH topology
3W30A 4D8EA 4REZA 4M0WA 1UKFA 3PHXA 5EZQA 4A5UA 3BY4A 3B21A 4D8BA 3IFUA 3TRKA 4RF0A 4IP3A 2DOSA 5KO3A 4HXDB 3W31A 1PVJA 2HWKA 3PSEA 2J7QC 2Z84A 4RNAA 4BOUA 4OW0A 3BB7A 4GUAA 2FE8A 4WURA 3OQCA 2UZJA 3PRPA 2BU3A 3RNVA 4D8IA 2JTCA 2J7QA 4BOZA 2BTWA 4BOSA 4MM3B 4IUMA 5E6JA 3MTVA 4BOQA 2JRIA 3PRMA 4P16A 3E9SA 2AGAA 3PHUA 3MP2A 3C0RA 1YZBA 3BBAA 4ZTBA 4PT5A 5EZSA 4R3DA 4XZXA 1DKIA 3O65A 4BOPA 3MJ5A 2BTWB 3ZNHA 4OVZA 3PT2A 4RKXA 4MI7A 3TMPA 4RF1A 5JZEA 4OVZB 3PHWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8E A;  3BB7 A;  1PVJ A;  4D8I A;  2JTC A;  1DKI A;  2UZJ A;  3BBA A;  4D8B A;  4RKX A; 
#chains in the Genus database with same CATH topology
 3W30 A;  2NQG A;  5EZQ A;  1QXP A;  2P7U A;  5K16 A;  5EGW A;  2E03 A;  1AU2 A;  1CV8 A;  3B79 A;  3IOQ A;  1U9V A;  2R9F A;  7PCK A;  3OIS A;  2G8E A;  2R9C A;  2AU1 A;  1NL6 A;  4IP3 A;  3IHP A;  2NQI A;  5KO3 A;  4Q8G A;  2E02 A;  4BQV A;  1NPZ A;  1F2C A;  2HWK A;  1PXV A;  2F7D A;  1NLJ A;  2HH5 A;  1F29 A;  4YYR A;  4RNA A;  2HD5 A;  1F2A A;  4OW0 A;  3BB7 A;  1EWP A;  1Y4H A;  2DCB A;  4MSX A;  3K24 A;  2FE8 A;  2FRQ A;  2IBI A;  3BWK A;  4P6G A;  1THE A;  2BDZ A;  1CB5 A;  4K7C A;  4W4U A;  1AYU A;  2YJ2 A;  1VSN A;  3RNV A;  1MS6 A;  3H8C A;  4CDF B;  2OZ2 A;  2R9O A;  2B1M A;  2Y6E A;  1NB3 A;  1AYV A;  3O1G A;  4HWY A;  2NQD B;  1O0E A;  4P6E A;  3MHS A;  1SNK A;  1PE6 A;  3PRM A;  4N8W A;  3KFQ A;  4W5C A;  1PCI A;  4P16 A;  4DMX A;  3PNR A;  5EF4 A;  1CJL A;  3AI8 A;  4XR7 A;  5F02 A;  2E00 A;  1MEM A;  2FTD A;  1KHQ A;  4YYV A;  1YVB A;  1DKI A;  2FO5 A;  4BOP A;  3KKU A;  3V6E A;  1YK8 A;  3QT4 A;  3PT2 A;  4RKX A;  2FT2 A;  3MOR A;  3NHE A;  5CHV A;  5JZE A;  4OVZ B;  1PPP A;  2JRI A;  1S4V A;  4D8E A;  3F75 A;  4A5U A;  1YK7 A;  3BY4 A;  3CH3 X;  3OVX A;  4YVA A;  2FYE A;  1CPJ A;  4CDE B;  1CS8 A;  2ARY A;  2AUX A;  3HD3 A;  3TRK A;  1ME3 A;  1ZCM A;  4RF0 A;  1PIP A;  1ITO A;  2ACT A;  2PAD A;  1X9Y A;  2ATO A;  2J7Q C;  2Z84 A;  4PAD A;  1CQD A;  1HUC B;  2Y5B A;  3P5X A;  1QDQ A;  3PDF A;  3H6S A;  1MHW A;  3OQC A;  1MIR A;  3WXF A;  4MZS A;  2FRA A;  1QMY A;  1TLO A;  2BU3 A;  2G6D A;  2JQF R;  1SP4 B;  2JTC A;  1K3B B;  1MEG A;  1F2B A;  2H7J A;  3D6S A;  4OEL A;  3IMA A;  2PRE A;  3HWN A;  1Q6K A;  3BCN A;  1XKG A;  2YJ9 A;  1PAD A;  8PCH A;  3MHH A;  1PPD A;  3IV2 A;  1EF7 A;  5JH3 A;  3U8E A;  1A6R A;  2DC7 A;  4AXL A;  4YYS A;  3QSD A;  2R9N A;  5A24 A;  1PPO A;  1DEU A;  3PHU A;  3ZUA A;  2AYN A;  4QBB A;  4N4Z A;  3MP2 A;  2VHS A;  3GCB A;  3K9M A;  1YZB A;  1NB5 A;  3BBA A;  4ZTB A;  3KW9 A;  3O65 A;  2BTW B;  4I05 A;  3KWZ A;  3CBK A;  1NQC A;  4CDD B;  2G8J A;  4BPV A;  5CVO B;  5CHT A;  3TMP A;  4RF1 A;  1AU0 A;  3PW3 A;  3CH2 X;  1BY8 A;  1BGO A;  4M0W A;  2G7Y A;  2C0Y A;  1UKF A;  3PHX A;  2CB5 A;  4N79 A;  4RY2 A;  3B21 A;  4D8B A;  3IFU A;  1U5I A;  2B1N A;  1PBH A;  2DCC A;  4HXD B;  4I07 A;  1PVJ A;  2FUD A;  1GLO A;  3PSE A;  3N4C A;  2P86 A;  2R6N A;  1EWO A;  1KFX L;  1STF E;  4I04 A;  4BOU A;  2DJF B;  4YYQ A;  3I3T A;  2IPP B;  1JQP A;  2DCD A;  2VHF A;  3V6C A;  2XU4 A;  3E1Z B;  3PRP A;  1YAL A;  2OP3 A;  3USV A;  2O6X A;  2AVW A;  4D8I A;  3KSE A;  4YYW A;  2R9M A;  2DC9 A;  2XU1 A;  4G54 A;  3LXS A;  4CDC B;  3KWB X;  4YV8 A;  4ZUX U;  4MM3 B;  3IEJ A;  5E6J A;  3S3Q A;  3WXG A;  1AU3 A;  1EWM A;  3MTV A;  2DJG B;  2AYO A;  3K8U A;  1TU6 A;  1ATK A;  1DF0 A;  2AGA A;  3DF0 A;  4FK5 A;  2DC8 A;  3OF8 A;  3H8B A;  4X6H A;  3N3K A;  2XU3 A;  3C9E A;  1AIM A;  1AEC A;  2YJ8 A;  5CVM A;  3C0R A;  3O0U A;  3KX1 A;  1ICF A;  4PT5 A;  2YJB A;  4AXM A;  1AYW A;  4XZX A;  4QH6 A;  5CVN B;  3HHI A;  2GFO A;  1EWL A;  3MTN A;  2BDL A;  4KLB A;  2DZY A;  3RVX A;  4MI7 A;  2DZZ A;  1BQI A;  4REZ A;  3I06 A;  4QRX A;  5JA7 A;  1PPN A;  4X6J A;  1POP A;  2AIM A;  4YYU A;  3P5W A;  5J94 A;  1U9W A;  3HHA A;  3LFY A;  3P5V A;  4Q8H A;  3CBJ A;  4PP2 E;  2DOS A;  1VJV A;  3W31 A;  4QRV A;  3H7D A;  3OVZ A;  1CVZ A;  3P5U A;  4MZO A;  1CSB B;  5PAD A;  1IWD A;  4FJC A;  2AS8 A;  2P0R A;  1CTE A;  3F5V A;  4PP1 A;  4GUA A;  2XU5 A;  3RVW A;  4BS6 A;  4WUR A;  1AU4 A;  1YT7 A;  2DC6 A;  1M6D A;  2UZJ A;  3RVV A;  2J7Q A;  3M99 A;  3WXE A;  1KXR A;  2NQA A;  4BOZ A;  2BTW A;  2OUL A;  2E01 A;  1KFU L;  2FQ9 A;  4BOS A;  4BS5 A;  2F1G A;  4CZW A;  1QOL A;  3H89 A;  4PI3 A;  4IUM A;  3N3G A;  1U9Q X;  2WBF X;  4BOQ A;  3BC3 A;  2AUZ A;  3TNX A;  1ME4 A;  1ZIV A;  1TL9 A;  1U9X A;  4XUI A;  2DCA A;  3E9S A;  4DMY A;  4BSQ A;  4X6I A;  3QJ3 A;  2JQG R;  3IUT A;  3ERV A;  6PAD A;  4QRG A;  4W5B A;  2YJC A;  1BP4 A;  5EZS A;  1GMY A;  4R3D A;  2CIO A;  2HXZ A;  3MJ5 A;  4WA6 A;  1GEC E;  2PBH A;  5FPW A;  1KHP A;  3ZNH A;  3BPF A;  1MDW A;  4OVZ A;  3BOW A;  1GCB A;  1Y08 A;  1FH0 A;  3OF9 A;  4OEM A;  3BPM A;  3PBH A;  9PAP A;  3S3R A;  2GHU A;  4FIP A;  2HHN A;  2PNS A;  3PHW A; 
#chains in the Genus database with same CATH homology
 3W30 A;  4D8E A;  4REZ A;  4M0W A;  1UKF A;  3PHX A;  5EZQ A;  4A5U A;  3BY4 A;  3B21 A;  4D8B A;  3IFU A;  3TRK A;  4RF0 A;  4IP3 A;  2DOS A;  5KO3 A;  4HXD B;  3W31 A;  1PVJ A;  2HWK A;  3PSE A;  2J7Q C;  2Z84 A;  4RNA A;  4BOU A;  4OW0 A;  3BB7 A;  4GUA A;  2FE8 A;  4WUR A;  3OQC A;  2UZJ A;  3PRP A;  2BU3 A;  3RNV A;  4D8I A;  2JTC A;  2J7Q A;  4BOZ A;  2BTW A;  4BOS A;  4MM3 B;  4IUM A;  5E6J A;  3MTV A;  4BOQ A;  2JRI A;  3PRM A;  4P16 A;  3E9S A;  2AGA A;  3PHU A;  3MP2 A;  3C0R A;  1YZB A;  3BBA A;  4ZTB A;  4PT5 A;  5EZS A;  4R3D A;  4XZX A;  1DKI A;  3O65 A;  4BOP A;  3MJ5 A;  2BTW B;  3ZNH A;  4OVZ A;  3PT2 A;  4RKX A;  4MI7 A;  3TMP A;  4RF1 A;  5JZE A;  4OVZ B;  3PHW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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