1TL9A

High resolution crystal structure of calpain i protease core in complex with leupeptin
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
321
structure length
321
Chain Sequence
NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site
pubmed doi rcsb
source organism Rattus norvegicus
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Calpain 1, large [catalytic] subunit
total genus 96
structure length 321
sequence length 321
ec nomenclature ec 3.4.22.52: Calpain-1.
pdb deposition date 2004-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00648 Peptidase_C2 Calpain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1tl9A02
2GFOA 2ATOA 3U8EA 1F29A 2AYOA 3MTNA 3CH3X 4X6HA 2C0YA 3P5XA 4AXLA 3LFYA 3I06A 4CDCB 3ERVA 3H6SA 2DC8A 1PPPA 1PXVA 1Y4HA 1O0EA 4Q8GA 2IBIA 1X9YA 3IHPA 1KXRA 4W5BA 5CVMA 3P5VA 5F02A 1KFXL 1KHPA 3HHIA 4QBBA 1AYWA 3PNRA 1NLJA 3E1ZB 1SP4B 3N3KA 2R9OA 3OF9A 3N4CA 5CVNB 1MHWA 2G8JA 1AU4A 2DC7A 1POPA 1EWPA 2E03A 3K9MA 9PAPA 1STFE 4PP2E 5J94A 4Q8HA 2HXZA 4BS6A 3M99A 1GMYA 2XU4A 3LXSA 1XKGA 3IEJA 2P0RA 3RVVA 1QMYA 2DJFB 1Q6KA 3O1GA 1U5IA 4YYQA 1S4VA 3V6EA 2DCBA 3KWZA 3H89A 2YJCA 3KWBX 1ICFA 3CBKA 2CIOA 4RY2A 2DZYA 5CHVA 2R6NA 1AU0A 1CPJA 2AYNA 5K16A 3WXFA 1ME3A 1AECA 1MIRA 2Y5BA 3IUTA 1HUCB 4FJCA 3TNXA 1CSBB 4OELA 3IOQA 3N3GA 4MZOA 1GCBA 4CDFB 1PIPA 1BP4A 3H8CA 3IMAA 1CB5A 1VJVA 1YK8A 2E00A 2PBHA 4QRXA 1PE6A 3IV2A 3WXEA 4BPVA 4YV8A 4N8WA 1GLOA 2FQ9A 3QT4A 1THEA 2VHFA 4BSQA 3I3TA 4FIPA 4N4ZA 1KHQA 3HWNA 1EWLA 1PCIA 1YT7A 1CQDA 4DMXA 1TU6A 4MZSA 2NQIA 2PADA 4PADA 3O0UA 2AU1A 4CDDB 3BWKA 4PP1A 4X6IA 1MEMA 2JQGR 1SNKA 4N79A 4QRGA 4WA6A 2YJ9A 3PW3A 2OZ2A 2FO5A 4HWYA 4XR7A 1U9QX 3USVA 4YYRA 4CZWA 3WXGA 1F2CA 4W5CA 3RVXA 2DC9A 3QSDA 3D6SA 1CV8A 1EWOA 2R9FA 3H8BA 4OEMA 1CJLA 3RVWA 3K8UA 3MHHA 3NHEA 1NPZA 2FYEA 3QJ3A 3DF0A 3CH2X 1U9XA 4AXMA 1K3BB 1QOLA 2E01A 2H7JA 3S3RA 1GECE 3GCBA 2NQGA 3HD3A 2O6XA 3K24A 4BS5A 4P6GA 2AIMA 3B79A 4YYSA 1AIMA 4YYWA 2G7YA 2JQFR 1NB5A 2BDZA 2G6DA 1NL6A 2NQDB 2P7UA 2DCCA 1EWMA 1KFUL 2AUXA 4CDEB 2AVWA 4PI3A 2F7DA 2HH5A 1BQIA 2AS8A 3OF8A 2DCDA 5CVOB 1MDWA 2BDLA 4MSXA 2WBFX 3F75A 1IWDA 5JH3A 1AU2A 4P6EA 3OVXA 2FUDA 1AU3A 3BOWA 1ZCMA 1NB3A 3KX1A 1ATKA 2FT2A 2YJBA 4I07A 4G54A 4XUIA 2DC6A 3PDFA 2DZZA 1Y08A 2Y6EA 1PBHA 3BCNA 4KLBA 3CBJA 1A6RA 4W4UA 3BPFA 1DF0A 8PCHA 3OVZA 3BPMA 1MEGA 2HHNA 3MHSA 3MORA 3KKUA 5EF4A 3KW9A 2GHUA 5CHTA 2PREA 1PADA 4ZUXU 4YVAA 3S3QA 2DJGB 2ARYA 2NQAA 2P86A 3V6CA 5EGWA 4DMYA 4YYVA 4QH6A 3HHAA 2CB5A 5PADA 1FH0A 2YJ2A 4YYUA 2VHSA 3BC3A 4I04A 2HD5A 3H7DA 5JA7A 1QXPA 2FTDA 1YVBA 1F2BA 1PPNA 4BQVA 1NQCA 1BGOA 3PBHA 2AUZA 6PADA 3KFQA 1U9WA 1VSNA 3F5VA 1TLOA 2XU5A 1CTEA 2OULA 1QDQA 1AYUA 2IPPB 4QRVA 1DEUA 1BY8A 1ZIVA 3P5UA 3P5WA 4K7CA 1CS8A 1EF7A 7PCKA 3OISA 3C9EA 2DCAA 2FRQA 2YJ8A 2XU3A 3ZUAA 2PNSA 3AI8A 1PPOA 2FRAA 1ITOA 4X6JA 1U9VA 1PPDA 2R9NA 2R9CA 5A24A 2E02A 1JQPA 2XU1A 1AYVA 4FK5A 1TL9A 1YK7A 2F1GA 5FPWA 1MS6A 2R9MA 2G8EA 3KSEA 2ACTA 4I05A 1YALA 1CVZA 1F2AA 1ME4A 2B1NA 2OP3A 1M6DA 2B1MA
chains in the Genus database with same CATH superfamily
2GFOA 2ATOA 3U8EA 1F29A 3PHWA 2AYOA 3MTNA 3CH3X 4X6HA 4REZA 2C0YA 3P5XA 4AXLA 4BOPA 3LFYA 3MJ5A 3I06A 4OW0A 4CDCB 3ERVA 4PT5A 3H6SA 2DC8A 1PPPA 4D8EA 4MI7A 1PXVA 1Y4HA 1O0EA 3BB7A 4Q8GA 5JZEA 2IBIA 1X9YA 3IHPA 4GUAA 1KXRA 4W5BA 5CVMA 3P5VA 5F02A 1KFXL 1KHPA 3HHIA 4QBBA 1AYWA 3PNRA 1NLJA 3E1ZB 1SP4B 3N3KA 2R9OA 3OF9A 3N4CA 5CVNB 1MHWA 2G8JA 2JRIA 1AU4A 4M0WA 2DC7A 1POPA 1EWPA 3W30A 2E03A 3K9MA 9PAPA 1STFE 4PP2E 5J94A 4Q8HA 2HXZA 4BS6A 3M99A 1GMYA 2XU4A 3LXSA 1XKGA 2AGAA 3IEJA 2P0RA 3RVVA 1QMYA 4RNAA 2DJFB 1Q6KA 3O1GA 1U5IA 4YYQA 4XZXA 1S4VA 3V6EA 2DCBA 3KWZA 3H89A 2Z84A 2YJCA 3PT2A 4RKXA 3KWBX 1ICFA 3CBKA 2CIOA 3PSEA 4RY2A 2DZYA 5CHVA 2R6NA 1AU0A 1CPJA 2AYNA 5K16A 3WXFA 5EZSA 1ME3A 1AECA 1MIRA 2Y5BA 3IUTA 1HUCB 4FJCA 3TNXA 1CSBB 4OELA 2HWKA 3IOQA 3N3GA 2UZJA 4MZOA 4WURA 1GCBA 4CDFB 1PIPA 1BP4A 3H8CA 3IMAA 1CB5A 1VJVA 1YK8A 2E00A 2PBHA 4QRXA 1PE6A 3IV2A 3WXEA 4BPVA 4YV8A 4N8WA 1GLOA 2FQ9A 4RF1A 3QT4A 1THEA 2VHFA 4BSQA 3I3TA 4FIPA 4N4ZA 1KHQA 3HWNA 1EWLA 4ZTBA 1PCIA 1YT7A 1CQDA 4DMXA 1TU6A 4MZSA 2NQIA 2PADA 4PADA 3BBAA 3O0UA 2AU1A 4CDDB 3BWKA 4PP1A 3W31A 4IP3A 4X6IA 1MEMA 2JQGR 1SNKA 4N79A 4QRGA 4BOUA 3PHXA 4WA6A 4D8IA 2YJ9A 3PW3A 2OZ2A 4OVZB 2FO5A 4HWYA 4XR7A 1U9QX 3USVA 4YYRA 4CZWA 3WXGA 1F2CA 4W5CA 3RVXA 4IUMA 1DKIA 2DC9A 3QSDA 3D6SA 1CV8A 2BU3A 1EWOA 2R9FA 3H8BA 4OEMA 1CJLA 5EZQA 3RVWA 3K8UA 3MHHA 3NHEA 1NPZA 2FYEA 3QJ3A 3DF0A 2J7QA 3CH2X 1U9XA 4AXMA 1K3BB 1QOLA 2E01A 2H7JA 3S3RA 1GECE 2FE8A 3GCBA 3MTVA 2NQGA 3HD3A 2O6XA 3C0RA 3K24A 4OVZA 4BS5A 4P6GA 4HXDB 3ZNHA 2AIMA 3B79A 4YYSA 1AIMA 4YYWA 2G7YA 2JQFR 1NB5A 2BDZA 2G6DA 4P16A 1NL6A 2NQDB 2P7UA 2DCCA 1EWMA 1KFUL 2AUXA 4CDEB 2AVWA 4PI3A 3TMPA 2F7DA 2HH5A 1BQIA 2AS8A 3OF8A 2DCDA 5CVOB 1MDWA 2BDLA 4MSXA 2WBFX 3F75A 1IWDA 5JH3A 1AU2A 4P6EA 3OVXA 2FUDA 1AU3A 4BOSA 3BOWA 1ZCMA 2BTWB 3TRKA 2DOSA 3BY4A 1NB3A 3KX1A 1ATKA 2FT2A 2YJBA 4I07A 4G54A 4XUIA 2DC6A 3PDFA 2DZZA 1Y08A 2Y6EA 1PBHA 3BCNA 4KLBA 3CBJA 1A6RA 4W4UA 3BPFA 2BTWA 1DF0A 8PCHA 3OVZA 3BPMA 4R3DA 1MEGA 2HHNA 3MP2A 3MHSA 3PRPA 3MORA 3KKUA 2J7QC 5EF4A 3KW9A 2GHUA 5CHTA 2PREA 1PADA 4ZUXU 1UKFA 4YVAA 3S3QA 2JTCA 2DJGB 2ARYA 2NQAA 2P86A 3V6CA 3E9SA 5EGWA 4DMYA 4YYVA 4QH6A 1YZBA 3IFUA 3HHAA 2CB5A 5PADA 1FH0A 2YJ2A 4YYUA 2VHSA 3BC3A 4I04A 2HD5A 3H7DA 5JA7A 4MM3B 1QXPA 2FTDA 1YVBA 1F2BA 1PPNA 4RF0A 4BQVA 1NQCA 1BGOA 3PBHA 2AUZA 6PADA 3KFQA 3O65A 3PRMA 3RNVA 1U9WA 1VSNA 3F5VA 1TLOA 2XU5A 4BOQA 1CTEA 2OULA 1QDQA 1AYUA 2IPPB 4QRVA 1DEUA 1BY8A 1ZIVA 3P5UA 3P5WA 4K7CA 1CS8A 1EF7A 7PCKA 3OISA 5KO3A 3C9EA 2DCAA 2FRQA 2YJ8A 2XU3A 5E6JA 3ZUAA 2PNSA 3AI8A 1PPOA 3B21A 2FRAA 1ITOA 4X6JA 1U9VA 1PPDA 4D8BA 2R9NA 2R9CA 5A24A 2E02A 1JQPA 2XU1A 1AYVA 4FK5A 1TL9A 1YK7A 2F1GA 5FPWA 1MS6A 2R9MA 2G8EA 3KSEA 3PHUA 2ACTA 4I05A 1YALA 4A5UA 1PVJA 1CVZA 1F2AA 1ME4A 2B1NA 2OP3A 1M6DA 2B1MA 4BOZA 3OQCA
chains in the Genus database with same CATH topology
2GFOA 2ATOA 3U8EA 1F29A 2AYOA 3MTNA 3CH3X 4X6HA 2C0YA 3P5XA 4AXLA 3LFYA 3I06A 4CDCB 3ERVA 3H6SA 2DC8A 1PPPA 1PXVA 1Y4HA 1O0EA 4Q8GA 2IBIA 1X9YA 3IHPA 1KXRA 4W5BA 5CVMA 3P5VA 5F02A 1KFXL 1KHPA 3HHIA 4QBBA 1AYWA 3PNRA 1NLJA 3E1ZB 1SP4B 3N3KA 2R9OA 3OF9A 3N4CA 5CVNB 1MHWA 2G8JA 1AU4A 2DC7A 1POPA 1EWPA 2E03A 3K9MA 9PAPA 1STFE 4PP2E 5J94A 4Q8HA 2HXZA 4BS6A 3M99A 1GMYA 2XU4A 3LXSA 1XKGA 3IEJA 3LTWA 2P0RA 3D9WA 3RVVA 1QMYA 4B55A 2VFBA 2DJFB 1Q6KA 3O1GA 1U5IA 4YYQA 1S4VA 3V6EA 2DCBA 3KWZA 3H89A 2YJCA 3KWBX 1ICFA 3CBKA 2CIOA 4RY2A 2DZYA 5CHVA 2R6NA 1AU0A 1CPJA 2AYNA 5K16A 3WXFA 1ME3A 1AECA 1MIRA 2Y5BA 3IUTA 1HUCB 4FJCA 3TNXA 1CSBB 4OELA 3IOQA 3N3GA 4MZOA 1GCBA 4CDFB 1PIPA 1BP4A 3H8CA 3IMAA 4NV7A 1CB5A 1VJVA 1YK8A 2E00A 2PBHA 4QRXA 1PE6A 3IV2A 3WXEA 4BPVA 4YV8A 4N8WA 1GLOA 2FQ9A 3QT4A 1THEA 2VHFA 4BSQA 3I3TA 4FIPA 4N4ZA 1KHQA 3HWNA 1EWLA 1PCIA 1YT7A 1CQDA 4DMXA 1TU6A 4MZSA 2NQIA 2PADA 4PADA 3O0UA 2AU1A 4CDDB 3BWKA 4PP1A 4X6IA 1MEMA 2JQGR 1SNKA 4N79A 4QRGA 4WA6A 2YJ9A 3PW3A 2OZ2A 2FO5A 4HWYA 4XR7A 1U9QX 3USVA 4C5PA 4YYRA 4CZWA 3WXGA 1F2CA 4W5CA 3RVXA 2DC9A 3QSDA 3D6SA 1CV8A 1EWOA 2R9FA 3H8BA 4OEMA 1CJLA 3RVWA 3K8UA 3MHHA 3NHEA 1NPZA 2FYEA 3QJ3A 3DF0A 3CH2X 1U9XA 4AXMA 1K3BB 1QOLA 2E01A 1W4TA 2H7JA 3S3RA 1GECE 3GCBA 2NQGA 3HD3A 2O6XA 3K24A 4BS5A 4P6GA 2AIMA 3B79A 4YYSA 1AIMA 4YYWA 2G7YA 2JQFR 1NB5A 2BDZA 2G6DA 1NL6A 2NQDB 2P7UA 2DCCA 1EWMA 1KFUL 2AUXA 4CDEB 2AVWA 4PI3A 2F7DA 2HH5A 1BQIA 2AS8A 3OF8A 2DCDA 5CVOB 1MDWA 2BDLA 4MSXA 2WBFX 3F75A 1IWDA 5JH3A 1AU2A 4P6EA 1GX3A 3OVXA 2FUDA 1AU3A 3BOWA 1ZCMA 1NB3A 3KX1A 1ATKA 2FT2A 2YJBA 4I07A 4G54A 4XUIA 2DC6A 3PDFA 2DZZA 1Y08A 4KLBA 2Y6EA 1PBHA 3BCNA 3CBJA 1A6RA 4W4UA 1W5RA 3BPFA 4GUZA 1DF0A 8PCHA 3OVZA 1W6FA 3BPMA 1MEGA 2HHNA 3MHSA 3MORA 3KKUA 5EF4A 3KW9A 2GHUA 5CHTA 2PREA 1PADA 4ZUXU 4YVAA 3S3QA 2DJGB 2ARYA 2NQAA 2P86A 3V6CA 5EGWA 4DMYA 4YYVA 4QH6A 3HHAA 2CB5A 5PADA 2VFCA 1FH0A 2YJ2A 4YYUA 2VHSA 3BC3A 4I04A 2HD5A 3H7DA 5JA7A 1QXPA 2FTDA 1YVBA 1F2BA 1PPNA 4BGFA 4BQVA 1NQCA 1BGOA 3PBHA 2AUZA 6PADA 3KFQA 1U9WA 1VSNA 3F5VA 1TLOA 2XU5A 1CTEA 2OULA 1QDQA 1AYUA 2IPPB 4QRVA 1DEUA 1BY8A 1ZIVA 4NV8A 3P5UA 3P5WA 4K7CA 1CS8A 1EF7A 7PCKA 3OISA 3C9EA 2DCAA 2FRQA 2YJ8A 2XU3A 3ZUAA 1E2TA 2PNSA 3AI8A 1PPOA 2FRAA 1ITOA 4X6JA 1U9VA 1PPDA 2R9NA 2R9CA 5A24A 2E02A 1JQPA 2XU1A 1AYVA 4FK5A 1TL9A 1YK7A 2F1GA 5FPWA 1MS6A 2R9MA 2G8EA 2BSZA 3KSEA 2ACTA 4I05A 1YALA 1CVZA 1F2AA 1ME4A 2B1NA 2OP3A 1M6DA 2B1MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GFO A;  2ATO A;  3U8E A;  1F29 A;  2AYO A;  3MTN A;  3CH3 X;  4X6H A;  2C0Y A;  3P5X A;  4AXL A;  3LFY A;  3I06 A;  4CDC B;  3ERV A;  3H6S A;  2DC8 A;  1PPP A;  1PXV A;  1Y4H A;  1O0E A;  4Q8G A;  2IBI A;  1X9Y A;  3IHP A;  1KXR A;  4W5B A;  5CVM A;  3P5V A;  5F02 A;  1KFX L;  1KHP A;  3HHI A;  4QBB A;  1AYW A;  3PNR A;  1NLJ A;  3E1Z B;  1SP4 B;  3N3K A;  2R9O A;  3OF9 A;  3N4C A;  5CVN B;  1MHW A;  2G8J A;  1AU4 A;  2DC7 A;  1POP A;  1EWP A;  2E03 A;  3K9M A;  9PAP A;  1STF E;  4PP2 E;  5J94 A;  4Q8H A;  2HXZ A;  4BS6 A;  3M99 A;  1GMY A;  2XU4 A;  3LXS A;  1XKG A;  3IEJ A;  2P0R A;  3RVV A;  1QMY A;  2DJF B;  1Q6K A;  3O1G A;  1U5I A;  4YYQ A;  1S4V A;  3V6E A;  2DCB A;  3KWZ A;  3H89 A;  2YJC A;  3KWB X;  1ICF A;  3CBK A;  2CIO A;  4RY2 A;  2DZY A;  5CHV A;  2R6N A;  1AU0 A;  1CPJ A;  2AYN A;  5K16 A;  3WXF A;  1ME3 A;  1AEC A;  1MIR A;  2Y5B A;  3IUT A;  1HUC B;  4FJC A;  3TNX A;  1CSB B;  4OEL A;  3IOQ A;  3N3G A;  4MZO A;  1GCB A;  4CDF B;  1PIP A;  1BP4 A;  3H8C A;  3IMA A;  1CB5 A;  1VJV A;  1YK8 A;  2E00 A;  2PBH A;  4QRX A;  1PE6 A;  3IV2 A;  3WXE A;  4BPV A;  4YV8 A;  4N8W A;  1GLO A;  2FQ9 A;  3QT4 A;  1THE A;  2VHF A;  4BSQ A;  3I3T A;  4FIP A;  4N4Z A;  1KHQ A;  3HWN A;  1EWL A;  1PCI A;  1YT7 A;  1CQD A;  4DMX A;  1TU6 A;  4MZS A;  2NQI A;  2PAD A;  4PAD A;  3O0U A;  2AU1 A;  4CDD B;  3BWK A;  4PP1 A;  4X6I A;  1MEM A;  2JQG R;  1SNK A;  4N79 A;  4QRG A;  4WA6 A;  2YJ9 A;  3PW3 A;  2OZ2 A;  2FO5 A;  4HWY A;  4XR7 A;  1U9Q X;  3USV A;  4YYR A;  4CZW A;  3WXG A;  1F2C A;  4W5C A;  3RVX A;  2DC9 A;  3QSD A;  3D6S A;  1CV8 A;  1EWO A;  2R9F A;  3H8B A;  4OEM A;  1CJL A;  3RVW A;  3K8U A;  3MHH A;  3NHE A;  1NPZ A;  2FYE A;  3QJ3 A;  3DF0 A;  3CH2 X;  1U9X A;  4AXM A;  1K3B B;  1QOL A;  2E01 A;  2H7J A;  3S3R A;  1GEC E;  3GCB A;  2NQG A;  3HD3 A;  2O6X A;  3K24 A;  4BS5 A;  4P6G A;  2AIM A;  3B79 A;  4YYS A;  1AIM A;  4YYW A;  2G7Y A;  2JQF R;  1NB5 A;  2BDZ A;  2G6D A;  1NL6 A;  2NQD B;  2P7U A;  2DCC A;  1EWM A;  1KFU L;  2AUX A;  4CDE B;  2AVW A;  4PI3 A;  2F7D A;  2HH5 A;  1BQI A;  2AS8 A;  3OF8 A;  2DCD A;  5CVO B;  1MDW A;  2BDL A;  4MSX A;  2WBF X;  3F75 A;  1IWD A;  5JH3 A;  1AU2 A;  4P6E A;  3OVX A;  2FUD A;  1AU3 A;  3BOW A;  1ZCM A;  1NB3 A;  3KX1 A;  1ATK A;  2FT2 A;  2YJB A;  4I07 A;  4G54 A;  4XUI A;  2DC6 A;  3PDF A;  2DZZ A;  1Y08 A;  2Y6E A;  1PBH A;  3BCN A;  4KLB A;  3CBJ A;  1A6R A;  4W4U A;  3BPF A;  1DF0 A;  8PCH A;  3OVZ A;  3BPM A;  1MEG A;  2HHN A;  3MHS A;  3MOR A;  3KKU A;  5EF4 A;  3KW9 A;  2GHU A;  5CHT A;  2PRE A;  1PAD A;  4ZUX U;  4YVA A;  3S3Q A;  2DJG B;  2ARY A;  2NQA A;  2P86 A;  3V6C A;  5EGW A;  4DMY A;  4YYV A;  4QH6 A;  3HHA A;  2CB5 A;  5PAD A;  1FH0 A;  2YJ2 A;  4YYU A;  2VHS A;  3BC3 A;  4I04 A;  2HD5 A;  3H7D A;  5JA7 A;  1QXP A;  2FTD A;  1YVB A;  1F2B A;  1PPN A;  4BQV A;  1NQC A;  1BGO A;  3PBH A;  2AUZ A;  6PAD A;  3KFQ A;  1U9W A;  1VSN A;  3F5V A;  1TLO A;  2XU5 A;  1CTE A;  2OUL A;  1QDQ A;  1AYU A;  2IPP B;  4QRV A;  1DEU A;  1BY8 A;  1ZIV A;  3P5U A;  3P5W A;  4K7C A;  1CS8 A;  1EF7 A;  7PCK A;  3OIS A;  3C9E A;  2DCA A;  2FRQ A;  2YJ8 A;  2XU3 A;  3ZUA A;  2PNS A;  3AI8 A;  1PPO A;  2FRA A;  1ITO A;  4X6J A;  1U9V A;  1PPD A;  2R9N A;  2R9C A;  5A24 A;  2E02 A;  1JQP A;  2XU1 A;  1AYV A;  4FK5 A;  1TL9 A;  1YK7 A;  2F1G A;  5FPW A;  1MS6 A;  2R9M A;  2G8E A;  3KSE A;  2ACT A;  4I05 A;  1YAL A;  1CVZ A;  1F2A A;  1ME4 A;  2B1N A;  2OP3 A;  1M6D A;  2B1M A; 
#chains in the Genus database with same CATH topology
 2GFO A;  2ATO A;  3U8E A;  1F29 A;  3PHW A;  2AYO A;  3MTN A;  3CH3 X;  4X6H A;  4REZ A;  2C0Y A;  3P5X A;  4AXL A;  4BOP A;  3LFY A;  3MJ5 A;  3I06 A;  4OW0 A;  4CDC B;  3ERV A;  4PT5 A;  3H6S A;  2DC8 A;  1PPP A;  4D8E A;  4MI7 A;  1PXV A;  1Y4H A;  1O0E A;  3BB7 A;  4Q8G A;  5JZE A;  2IBI A;  1X9Y A;  3IHP A;  4GUA A;  1KXR A;  4W5B A;  5CVM A;  3P5V A;  5F02 A;  1KFX L;  1KHP A;  3HHI A;  4QBB A;  1AYW A;  3PNR A;  1NLJ A;  3E1Z B;  1SP4 B;  3N3K A;  2R9O A;  3OF9 A;  3N4C A;  5CVN B;  1MHW A;  2G8J A;  2JRI A;  1AU4 A;  4M0W A;  2DC7 A;  1POP A;  1EWP A;  3W30 A;  2E03 A;  3K9M A;  9PAP A;  1STF E;  4PP2 E;  5J94 A;  4Q8H A;  2HXZ A;  4BS6 A;  3M99 A;  1GMY A;  2XU4 A;  3LXS A;  1XKG A;  2AGA A;  3IEJ A;  2P0R A;  3RVV A;  1QMY A;  4RNA A;  2DJF B;  1Q6K A;  3O1G A;  1U5I A;  4YYQ A;  4XZX A;  1S4V A;  3V6E A;  2DCB A;  3KWZ A;  3H89 A;  2Z84 A;  2YJC A;  3PT2 A;  4RKX A;  3KWB X;  1ICF A;  3CBK A;  2CIO A;  3PSE A;  4RY2 A;  2DZY A;  5CHV A;  2R6N A;  1AU0 A;  1CPJ A;  2AYN A;  5K16 A;  3WXF A;  5EZS A;  1ME3 A;  1AEC A;  1MIR A;  2Y5B A;  3IUT A;  1HUC B;  4FJC A;  3TNX A;  1CSB B;  4OEL A;  2HWK A;  3IOQ A;  3N3G A;  2UZJ A;  4MZO A;  4WUR A;  1GCB A;  4CDF B;  1PIP A;  1BP4 A;  3H8C A;  3IMA A;  1CB5 A;  1VJV A;  1YK8 A;  2E00 A;  2PBH A;  4QRX A;  1PE6 A;  3IV2 A;  3WXE A;  4BPV A;  4YV8 A;  4N8W A;  1GLO A;  2FQ9 A;  4RF1 A;  3QT4 A;  1THE A;  2VHF A;  4BSQ A;  3I3T A;  4FIP A;  4N4Z A;  1KHQ A;  3HWN A;  1EWL A;  4ZTB A;  1PCI A;  1YT7 A;  1CQD A;  4DMX A;  1TU6 A;  4MZS A;  2NQI A;  2PAD A;  4PAD A;  3BBA A;  3O0U A;  2AU1 A;  4CDD B;  3BWK A;  4PP1 A;  3W31 A;  4IP3 A;  4X6I A;  1MEM A;  2JQG R;  1SNK A;  4N79 A;  4QRG A;  4BOU A;  3PHX A;  4WA6 A;  4D8I A;  2YJ9 A;  3PW3 A;  2OZ2 A;  4OVZ B;  2FO5 A;  4HWY A;  4XR7 A;  1U9Q X;  3USV A;  4YYR A;  4CZW A;  3WXG A;  1F2C A;  4W5C A;  3RVX A;  4IUM A;  1DKI A;  2DC9 A;  3QSD A;  3D6S A;  1CV8 A;  2BU3 A;  1EWO A;  2R9F A;  3H8B A;  4OEM A;  1CJL A;  5EZQ A;  3RVW A;  3K8U A;  3MHH A;  3NHE A;  1NPZ A;  2FYE A;  3QJ3 A;  3DF0 A;  2J7Q A;  3CH2 X;  1U9X A;  4AXM A;  1K3B B;  1QOL A;  2E01 A;  2H7J A;  3S3R A;  1GEC E;  2FE8 A;  3GCB A;  3MTV A;  2NQG A;  3HD3 A;  2O6X A;  3C0R A;  3K24 A;  4OVZ A;  4BS5 A;  4P6G A;  4HXD B;  3ZNH A;  2AIM A;  3B79 A;  4YYS A;  1AIM A;  4YYW A;  2G7Y A;  2JQF R;  1NB5 A;  2BDZ A;  2G6D A;  4P16 A;  1NL6 A;  2NQD B;  2P7U A;  2DCC A;  1EWM A;  1KFU L;  2AUX A;  4CDE B;  2AVW A;  4PI3 A;  3TMP A;  2F7D A;  2HH5 A;  1BQI A;  2AS8 A;  3OF8 A;  2DCD A;  5CVO B;  1MDW A;  2BDL A;  4MSX A;  2WBF X;  3F75 A;  1IWD A;  5JH3 A;  1AU2 A;  4P6E A;  3OVX A;  2FUD A;  1AU3 A;  4BOS A;  3BOW A;  1ZCM A;  2BTW B;  3TRK A;  2DOS A;  3BY4 A;  1NB3 A;  3KX1 A;  1ATK A;  2FT2 A;  2YJB A;  4I07 A;  4G54 A;  4XUI A;  2DC6 A;  3PDF A;  2DZZ A;  1Y08 A;  2Y6E A;  1PBH A;  3BCN A;  4KLB A;  3CBJ A;  1A6R A;  4W4U A;  3BPF A;  2BTW A;  1DF0 A;  8PCH A;  3OVZ A;  3BPM A;  4R3D A;  1MEG A;  2HHN A;  3MP2 A;  3MHS A;  3PRP A;  3MOR A;  3KKU A;  2J7Q C;  5EF4 A;  3KW9 A;  2GHU A;  5CHT A;  2PRE A;  1PAD A;  4ZUX U;  1UKF A;  4YVA A;  3S3Q A;  2JTC A;  2DJG B;  2ARY A;  2NQA A;  2P86 A;  3V6C A;  3E9S A;  5EGW A;  4DMY A;  4YYV A;  4QH6 A;  1YZB A;  3IFU A;  3HHA A;  2CB5 A;  5PAD A;  1FH0 A;  2YJ2 A;  4YYU A;  2VHS A;  3BC3 A;  4I04 A;  2HD5 A;  3H7D A;  5JA7 A;  4MM3 B;  1QXP A;  2FTD A;  1YVB A;  1F2B A;  1PPN A;  4RF0 A;  4BQV A;  1NQC A;  1BGO A;  3PBH A;  2AUZ A;  6PAD A;  3KFQ A;  3O65 A;  3PRM A;  3RNV A;  1U9W A;  1VSN A;  3F5V A;  1TLO A;  2XU5 A;  4BOQ A;  1CTE A;  2OUL A;  1QDQ A;  1AYU A;  2IPP B;  4QRV A;  1DEU A;  1BY8 A;  1ZIV A;  3P5U A;  3P5W A;  4K7C A;  1CS8 A;  1EF7 A;  7PCK A;  3OIS A;  5KO3 A;  3C9E A;  2DCA A;  2FRQ A;  2YJ8 A;  2XU3 A;  5E6J A;  3ZUA A;  2PNS A;  3AI8 A;  1PPO A;  3B21 A;  2FRA A;  1ITO A;  4X6J A;  1U9V A;  1PPD A;  4D8B A;  2R9N A;  2R9C A;  5A24 A;  2E02 A;  1JQP A;  2XU1 A;  1AYV A;  4FK5 A;  1TL9 A;  1YK7 A;  2F1G A;  5FPW A;  1MS6 A;  2R9M A;  2G8E A;  3KSE A;  3PHU A;  2ACT A;  4I05 A;  1YAL A;  4A5U A;  1PVJ A;  1CVZ A;  1F2A A;  1ME4 A;  2B1N A;  2OP3 A;  1M6D A;  2B1M A;  4BOZ A;  3OQC A; 
#chains in the Genus database with same CATH homology
 2GFO A;  2ATO A;  3U8E A;  1F29 A;  2AYO A;  3MTN A;  3CH3 X;  4X6H A;  2C0Y A;  3P5X A;  4AXL A;  3LFY A;  3I06 A;  4CDC B;  3ERV A;  3H6S A;  2DC8 A;  1PPP A;  1PXV A;  1Y4H A;  1O0E A;  4Q8G A;  2IBI A;  1X9Y A;  3IHP A;  1KXR A;  4W5B A;  5CVM A;  3P5V A;  5F02 A;  1KFX L;  1KHP A;  3HHI A;  4QBB A;  1AYW A;  3PNR A;  1NLJ A;  3E1Z B;  1SP4 B;  3N3K A;  2R9O A;  3OF9 A;  3N4C A;  5CVN B;  1MHW A;  2G8J A;  1AU4 A;  2DC7 A;  1POP A;  1EWP A;  2E03 A;  3K9M A;  9PAP A;  1STF E;  4PP2 E;  5J94 A;  4Q8H A;  2HXZ A;  4BS6 A;  3M99 A;  1GMY A;  2XU4 A;  3LXS A;  1XKG A;  3IEJ A;  3LTW A;  2P0R A;  3D9W A;  3RVV A;  1QMY A;  4B55 A;  2VFB A;  2DJF B;  1Q6K A;  3O1G A;  1U5I A;  4YYQ A;  1S4V A;  3V6E A;  2DCB A;  3KWZ A;  3H89 A;  2YJC A;  3KWB X;  1ICF A;  3CBK A;  2CIO A;  4RY2 A;  2DZY A;  5CHV A;  2R6N A;  1AU0 A;  1CPJ A;  2AYN A;  5K16 A;  3WXF A;  1ME3 A;  1AEC A;  1MIR A;  2Y5B A;  3IUT A;  1HUC B;  4FJC A;  3TNX A;  1CSB B;  4OEL A;  3IOQ A;  3N3G A;  4MZO A;  1GCB A;  4CDF B;  1PIP A;  1BP4 A;  3H8C A;  3IMA A;  4NV7 A;  1CB5 A;  1VJV A;  1YK8 A;  2E00 A;  2PBH A;  4QRX A;  1PE6 A;  3IV2 A;  3WXE A;  4BPV A;  4YV8 A;  4N8W A;  1GLO A;  2FQ9 A;  3QT4 A;  1THE A;  2VHF A;  4BSQ A;  3I3T A;  4FIP A;  4N4Z A;  1KHQ A;  3HWN A;  1EWL A;  1PCI A;  1YT7 A;  1CQD A;  4DMX A;  1TU6 A;  4MZS A;  2NQI A;  2PAD A;  4PAD A;  3O0U A;  2AU1 A;  4CDD B;  3BWK A;  4PP1 A;  4X6I A;  1MEM A;  2JQG R;  1SNK A;  4N79 A;  4QRG A;  4WA6 A;  2YJ9 A;  3PW3 A;  2OZ2 A;  2FO5 A;  4HWY A;  4XR7 A;  1U9Q X;  3USV A;  4C5P A;  4YYR A;  4CZW A;  3WXG A;  1F2C A;  4W5C A;  3RVX A;  2DC9 A;  3QSD A;  3D6S A;  1CV8 A;  1EWO A;  2R9F A;  3H8B A;  4OEM A;  1CJL A;  3RVW A;  3K8U A;  3MHH A;  3NHE A;  1NPZ A;  2FYE A;  3QJ3 A;  3DF0 A;  3CH2 X;  1U9X A;  4AXM A;  1K3B B;  1QOL A;  2E01 A;  1W4T A;  2H7J A;  3S3R A;  1GEC E;  3GCB A;  2NQG A;  3HD3 A;  2O6X A;  3K24 A;  4BS5 A;  4P6G A;  2AIM A;  3B79 A;  4YYS A;  1AIM A;  4YYW A;  2G7Y A;  2JQF R;  1NB5 A;  2BDZ A;  2G6D A;  1NL6 A;  2NQD B;  2P7U A;  2DCC A;  1EWM A;  1KFU L;  2AUX A;  4CDE B;  2AVW A;  4PI3 A;  2F7D A;  2HH5 A;  1BQI A;  2AS8 A;  3OF8 A;  2DCD A;  5CVO B;  1MDW A;  2BDL A;  4MSX A;  2WBF X;  3F75 A;  1IWD A;  5JH3 A;  1AU2 A;  4P6E A;  1GX3 A;  3OVX A;  2FUD A;  1AU3 A;  3BOW A;  1ZCM A;  1NB3 A;  3KX1 A;  1ATK A;  2FT2 A;  2YJB A;  4I07 A;  4G54 A;  4XUI A;  2DC6 A;  3PDF A;  2DZZ A;  1Y08 A;  4KLB A;  2Y6E A;  1PBH A;  3BCN A;  3CBJ A;  1A6R A;  4W4U A;  1W5R A;  3BPF A;  4GUZ A;  1DF0 A;  8PCH A;  3OVZ A;  1W6F A;  3BPM A;  1MEG A;  2HHN A;  3MHS A;  3MOR A;  3KKU A;  5EF4 A;  3KW9 A;  2GHU A;  5CHT A;  2PRE A;  1PAD A;  4ZUX U;  4YVA A;  3S3Q A;  2DJG B;  2ARY A;  2NQA A;  2P86 A;  3V6C A;  5EGW A;  4DMY A;  4YYV A;  4QH6 A;  3HHA A;  2CB5 A;  5PAD A;  2VFC A;  1FH0 A;  2YJ2 A;  4YYU A;  2VHS A;  3BC3 A;  4I04 A;  2HD5 A;  3H7D A;  5JA7 A;  1QXP A;  2FTD A;  1YVB A;  1F2B A;  1PPN A;  4BGF A;  4BQV A;  1NQC A;  1BGO A;  3PBH A;  2AUZ A;  6PAD A;  3KFQ A;  1U9W A;  1VSN A;  3F5V A;  1TLO A;  2XU5 A;  1CTE A;  2OUL A;  1QDQ A;  1AYU A;  2IPP B;  4QRV A;  1DEU A;  1BY8 A;  1ZIV A;  4NV8 A;  3P5U A;  3P5W A;  4K7C A;  1CS8 A;  1EF7 A;  7PCK A;  3OIS A;  3C9E A;  2DCA A;  2FRQ A;  2YJ8 A;  2XU3 A;  3ZUA A;  1E2T A;  2PNS A;  3AI8 A;  1PPO A;  2FRA A;  1ITO A;  4X6J A;  1U9V A;  1PPD A;  2R9N A;  2R9C A;  5A24 A;  2E02 A;  1JQP A;  2XU1 A;  1AYV A;  4FK5 A;  1TL9 A;  1YK7 A;  2F1G A;  5FPW A;  1MS6 A;  2R9M A;  2G8E A;  2BSZ A;  3KSE A;  2ACT A;  4I05 A;  1YAL A;  1CVZ A;  1F2A A;  1ME4 A;  2B1N A;  2OP3 A;  1M6D A;  2B1M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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