4P6EA

Crystal structure of human cathepsin s bound to a non-covalent inhibitor
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
219
structure length
219
Chain Sequence
ILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEIE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Cathepsin S
total genus 69
structure length 219
sequence length 219
chains with identical sequence B
ec nomenclature ec 3.4.22.27: Cathepsin S.
pdb deposition date 2014-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4p6eA00
1FH0A 1U9WA 1BP4A 5JH3A 5K16A 4KLBA 2AS8A 4FIPA 3MHSA 2DCCA 2R6NA 4YYRA 2DCBA 2PBHA 5CVNB 1PE6A 2YJ8A 4AXLA 1M6DA 2FRQA 3IUTA 1ME3A 1Y08A 4YYSA 1U9XA 1K3BB 2VHSA 1ICFA 4X6JA 4P6GA 1NPZA 2HH5A 4PP1A 1TU6A 1O0EA 4X6HA 1AU2A 3OF9A 2P7UA 4BS6A 3KFQA 4N4ZA 1POPA 3IV2A 4P6EA 3RVXA 1TLOA 1DEUA 1KHQA 4MSXA 2DC8A 3KKUA 2AU1A 3H8CA 3RVVA 5A24A 3OF8A 2E02A 5CHTA 4ZUXU 1GLOA 2E01A 3D6SA 3NHEA 2GHUA 4Q8GA 3P5VA 1BQIA 4W4UA 5FPWA 1CTEA 2BDLA 5EGWA 4OELA 2G8JA 3CH2X 4G54A 4BQVA 2YJCA 3OISA 4QRGA 1XKGA 2OULA 3BPFA 2ACTA 4CDFB 2R9OA 3USVA 4I04A 1PADA 3QJ3A 2JQGR 2G7YA 4CDEB 1GCBA 1NLJA 1MEMA 2YJ2A 1NB3A 3KW9A 2XU1A 3N3KA 3B79A 3E1ZB 3RVWA 1F2BA 1AU4A 3S3RA 3GCBA 3WXGA 3O1GA 4DMXA 1QDQA 2NQGA 3H89A 2VHFA 5JA7A 3WXFA 7PCKA 1HUCB 4QH6A 1EWLA 2GFOA 1KFUL 2ARYA 5CVOB 3P5UA 4QRXA 2NQIA 3V6CA 4CDDB 1F2CA 4WA6A 3LXSA 1EF7A 1YT7A 2DZYA 1AU0A 2DC7A 2Y6EA 2HD5A 3TNXA 4N79A 5EF4A 3PNRA 3CBKA 3IMAA 4MZSA 2AUXA 3I3TA 4AXMA 2DZZA 4YYWA 3MHHA 6PADA 2ATOA 5PADA 1EWMA 5CVMA 2CB5A 3KX1A 4CZWA 1PPDA 1PPPA 2F7DA 1MIRA 1ITOA 1IWDA 1CVZA 1MHWA 1PBHA 1S4VA 2G6DA 3BC3A 1PPOA 2DJFB 2XU3A 1AYUA 2FO5A 4PADA 2NQDB 1SP4B 1SNKA 2HXZA 3H8BA 2O6XA 2AYNA 2P86A 3KWBX 1ZIVA 1GMYA 4I07A 3BPMA 3MTNA 4YYQA 4I05A 1F2AA 2DC6A 3P5XA 4FJCA 2OP3A 4DMYA 4XUIA 4YVAA 1PIPA 1YALA 3KSEA 1CB5A 1NL6A 2XU4A 4CDCB 1MS6A 3BWKA 1KXRA 3M99A 2DCDA 3K9MA 3F75A 1ATKA 4X6IA 2R9MA 1YK8A 3CH3X 2C0YA 1PPNA 1AYVA 1CPJA 2R9NA 4QRVA 4W5CA 4PI3A 1THEA 3N4CA 3KWZA 3HHAA 3S3QA 2OZ2A 2YJ9A 2WBFX 3PW3A 2IPPB 3I06A 1ZCMA 4YV8A 1X9YA 3C9EA 3HD3A 1KFXL 3ZUAA 1JQPA 1Q6KA 1CJLA 3F5VA 1YVBA 1MDWA 1CQDA 3DF0A 1NB5A 2Y5BA 4RY2A 4QBBA 2B1NA 3HWNA 2PNSA 3V6EA 2G8EA 3MORA 1NQCA 2FYEA 3IOQA 3U8EA 2FQ9A 4BPVA 3LFYA 4N8WA 4BS5A 4K7CA 3QT4A 2JQFR 1U9VA 4XR7A 2B1MA 4YYUA 1KHPA 2E03A 2R9FA 1EWOA 1TL9A 2NQAA 4OEMA 2YJBA 2DCAA 4MZOA 3OVZA 1CS8A 1PXVA 2HHNA 3ERVA 1U9QX 1BGOA 2DC9A 2IBIA 1QOLA 2DJGB 3K24A 1QMYA 4W5BA 9PAPA 2E00A 2AUZA 1BY8A 1DF0A 3O0UA 3HHIA 1GECE 2AIMA 4HWYA 1A6RA 1CV8A 2R9CA 1PCIA 2CIOA 4PP2E 1Y4HA 3H7DA 3BCNA 4FK5A 1F29A 3N3GA 1YK7A 3PDFA 1AIMA 2P0RA 1STFE 2F1GA 3QSDA 1AYWA 5J94A 1ME4A 3K8UA 3CBJA 3BOWA 2BDZA 3PBHA 3WXEA 2H7JA 1VJVA 2FUDA 2AVWA 3IEJA 3P5WA 3H6SA 4Q8HA 1CSBB 2PREA 1U5IA 2XU5A 4YYVA 1EWPA 2FTDA 3OVXA 2PADA 2AYOA 1MEGA 4BSQA 1QXPA 1VSNA 3AI8A 2FT2A 1AECA 1AU3A 8PCHA 3IHPA 5CHVA 5F02A 2FRAA
chains in the Genus database with same CATH superfamily
1FH0A 1U9WA 1BP4A 5JH3A 5K16A 2AGAA 4KLBA 2AS8A 4FIPA 1PVJA 3MHSA 2DCCA 2R6NA 4YYRA 2DCBA 2PBHA 5CVNB 1PE6A 3TRKA 2JTCA 2YJ8A 4AXLA 1M6DA 3PHWA 2FRQA 3IUTA 1ME3A 1Y08A 4YYSA 1U9XA 1K3BB 4IP3A 2VHSA 1ICFA 4X6JA 4P6GA 1NPZA 2HH5A 4PP1A 1TU6A 1O0EA 4X6HA 1AU2A 3OF9A 2P7UA 4BS6A 4RF1A 3KFQA 1UKFA 4N4ZA 1POPA 3IV2A 4P6EA 3RVXA 1TLOA 1DEUA 1KHQA 4MSXA 2DC8A 3KKUA 2AU1A 3H8CA 3RVVA 5A24A 3OF8A 2E02A 5CHTA 4MI7A 4ZUXU 1GLOA 2E01A 3D6SA 3NHEA 2GHUA 4Q8GA 3P5VA 1BQIA 4W4UA 3OQCA 5FPWA 2Z84A 1CTEA 4ZTBA 2BDLA 5EGWA 4OELA 2G8JA 3CH2X 4G54A 3PRMA 4BQVA 2YJCA 3OISA 4QRGA 3RNVA 1XKGA 2OULA 3BPFA 3TMPA 2ACTA 4CDFB 4D8BA 3E9SA 2R9OA 3USVA 4I04A 4OW0A 5E6JA 1PADA 3QJ3A 4RNAA 2JQGR 2G7YA 4CDEB 1GCBA 4M0WA 1NLJA 1MEMA 2YJ2A 1NB3A 3KW9A 3W30A 2XU1A 3N3KA 3B79A 3E1ZB 3RVWA 1F2BA 1AU4A 3S3RA 3GCBA 3WXGA 3O1GA 4DMXA 1QDQA 3BBAA 2NQGA 3H89A 2VHFA 2UZJA 5JA7A 3WXFA 7PCKA 4REZA 1HUCB 4QH6A 1EWLA 2GFOA 1KFUL 4GUAA 2ARYA 5CVOB 3P5UA 4QRXA 3W31A 2NQIA 3V6CA 4CDDB 1F2CA 4WA6A 3LXSA 3PT2A 1EF7A 1YT7A 2DZYA 1AU0A 2DC7A 2Y6EA 2HD5A 3TNXA 4D8IA 4N79A 5EF4A 3PNRA 3CBKA 3IMAA 4MZSA 3BY4A 2AUXA 4IUMA 3I3TA 4AXMA 5EZQA 4R3DA 2J7QA 2DZZA 4YYWA 3MHHA 6PADA 2ATOA 2HWKA 5PADA 1EWMA 5CVMA 2CB5A 3KX1A 2J7QC 4WURA 4CZWA 1PPDA 1PPPA 2F7DA 1MIRA 4RF0A 1ITOA 1IWDA 1CVZA 1MHWA 1PBHA 1S4VA 2G6DA 3MJ5A 3BC3A 1PPOA 2DJFB 2XU3A 1AYUA 2FO5A 4PADA 2NQDB 1SP4B 1SNKA 2HXZA 3H8BA 2O6XA 2AYNA 2P86A 1DKIA 3KWBX 1ZIVA 4D8EA 1GMYA 4I07A 4MM3B 3BPMA 3MTNA 4YYQA 4RKXA 4I05A 1F2AA 2DC6A 3P5XA 2BTWB 4FJCA 2OP3A 4DMYA 4XUIA 4YVAA 1PIPA 1YALA 3KSEA 4XZXA 1CB5A 1NL6A 3BB7A 2XU4A 4CDCB 4OVZB 1MS6A 3BWKA 1KXRA 3MTVA 3M99A 2DCDA 3K9MA 3F75A 1ATKA 4X6IA 3PRPA 4BOUA 2R9MA 1YK8A 3CH3X 2C0YA 1PPNA 1AYVA 1CPJA 2R9NA 4QRVA 4W5CA 4PI3A 5JZEA 1THEA 3N4CA 3KWZA 3HHAA 3S3QA 2FE8A 3PHUA 2OZ2A 2YJ9A 2WBFX 3PW3A 2IPPB 3I06A 1ZCMA 4BOPA 4YV8A 1X9YA 3C9EA 3HD3A 4A5UA 1KFXL 3ZUAA 2BTWA 1JQPA 1Q6KA 1CJLA 3F5VA 1YVBA 1MDWA 1CQDA 3DF0A 1NB5A 3C0RA 2Y5BA 4RY2A 4QBBA 4OVZA 2B1NA 3HWNA 3O65A 2PNSA 3V6EA 4BOSA 3IFUA 2G8EA 3MORA 1NQCA 2FYEA 3IOQA 3U8EA 4P16A 2FQ9A 4BPVA 3LFYA 4N8WA 4BS5A 4K7CA 3QT4A 2JQFR 1U9VA 4XR7A 2B1MA 4YYUA 1KHPA 2E03A 2R9FA 3MP2A 1EWOA 1TL9A 2NQAA 4OEMA 2YJBA 2DCAA 4MZOA 3OVZA 1CS8A 1PXVA 2HHNA 3ERVA 1U9QX 1BGOA 2DC9A 2IBIA 1QOLA 2DJGB 3K24A 1QMYA 4W5BA 2BU3A 2DOSA 9PAPA 2E00A 2AUZA 1BY8A 1DF0A 4BOZA 3O0UA 3HHIA 1GECE 2AIMA 4HXDB 4HWYA 1A6RA 1CV8A 2R9CA 1PCIA 3ZNHA 2CIOA 4PP2E 1Y4HA 3H7DA 3BCNA 5EZSA 4FK5A 1F29A 3N3GA 1YK7A 3PDFA 1AIMA 4PT5A 2P0RA 1YZBA 3PSEA 1STFE 2F1GA 3QSDA 3B21A 1AYWA 5J94A 3PHXA 1ME4A 3K8UA 3CBJA 3BOWA 2BDZA 3PBHA 3WXEA 2H7JA 1VJVA 2FUDA 2JRIA 2AVWA 3IEJA 3P5WA 3H6SA 4Q8HA 1CSBB 2PREA 1U5IA 2XU5A 4YYVA 1EWPA 2FTDA 3OVXA 2PADA 2AYOA 1MEGA 4BSQA 1QXPA 1VSNA 3AI8A 2FT2A 5KO3A 4BOQA 1AECA 1AU3A 8PCHA 3IHPA 5CHVA 5F02A 2FRAA
chains in the Genus database with same CATH topology
1FH0A 1U9WA 1BP4A 5JH3A 5K16A 4KLBA 2AS8A 4FIPA 3MHSA 2DCCA 2R6NA 4YYRA 2DCBA 2PBHA 5CVNB 1PE6A 2YJ8A 4AXLA 1M6DA 2FRQA 3IUTA 1ME3A 1Y08A 4YYSA 1U9XA 1K3BB 2VHSA 1ICFA 4X6JA 4P6GA 1NPZA 2HH5A 4PP1A 1TU6A 1O0EA 4X6HA 1AU2A 3OF9A 2P7UA 4BS6A 3KFQA 4N4ZA 1POPA 3IV2A 4P6EA 3RVXA 1TLOA 1DEUA 1KHQA 4MSXA 2DC8A 3KKUA 2AU1A 3H8CA 3RVVA 5A24A 3OF8A 2E02A 5CHTA 4ZUXU 1GLOA 2E01A 3D6SA 3NHEA 2GHUA 4Q8GA 3P5VA 1BQIA 4W4UA 5FPWA 1CTEA 4GUZA 2BDLA 5EGWA 4OELA 2G8JA 3CH2X 4G54A 4BQVA 2YJCA 3OISA 4QRGA 1XKGA 2OULA 3BPFA 2ACTA 4CDFB 2R9OA 3USVA 4I04A 4B55A 1PADA 3QJ3A 2JQGR 2G7YA 4CDEB 1GCBA 1NLJA 1MEMA 4NV7A 2YJ2A 1NB3A 3KW9A 2XU1A 3N3KA 3B79A 3E1ZB 3RVWA 1F2BA 1AU4A 3S3RA 3GCBA 3WXGA 3O1GA 4DMXA 1QDQA 2NQGA 3H89A 2VHFA 5JA7A 3WXFA 7PCKA 1HUCB 4QH6A 1EWLA 3D9WA 2GFOA 1KFUL 2ARYA 5CVOB 3P5UA 4QRXA 2NQIA 3V6CA 4CDDB 1F2CA 4WA6A 3LXSA 1EF7A 1YT7A 2DZYA 1AU0A 2DC7A 2VFCA 2Y6EA 2HD5A 3TNXA 2VFBA 4N79A 5EF4A 3PNRA 3CBKA 3IMAA 4MZSA 2AUXA 3I3TA 4AXMA 2DZZA 4YYWA 3MHHA 6PADA 2ATOA 5PADA 1EWMA 5CVMA 2CB5A 3KX1A 4CZWA 1PPDA 1PPPA 2F7DA 1MIRA 1E2TA 1ITOA 1IWDA 1CVZA 1MHWA 1PBHA 1S4VA 2G6DA 3BC3A 1PPOA 2DJFB 2XU3A 1AYUA 2FO5A 4PADA 2NQDB 1SP4B 1SNKA 2HXZA 3H8BA 2O6XA 2AYNA 2P86A 3KWBX 1ZIVA 1GMYA 4I07A 3BPMA 3MTNA 4YYQA 4I05A 1F2AA 2DC6A 3P5XA 4FJCA 2OP3A 4DMYA 4XUIA 4YVAA 1PIPA 1YALA 3KSEA 1CB5A 1NL6A 2XU4A 4CDCB 1MS6A 3BWKA 1KXRA 3M99A 2DCDA 3K9MA 3F75A 1ATKA 4X6IA 2BSZA 2R9MA 1YK8A 3CH3X 2C0YA 1PPNA 1AYVA 1CPJA 2R9NA 4QRVA 4W5CA 4PI3A 1THEA 3N4CA 3KWZA 3HHAA 3S3QA 2OZ2A 2YJ9A 2WBFX 3PW3A 2IPPB 3I06A 1ZCMA 4YV8A 1X9YA 3C9EA 3HD3A 1KFXL 3ZUAA 1JQPA 1Q6KA 1CJLA 3F5VA 1YVBA 1MDWA 1CQDA 3DF0A 1NB5A 2Y5BA 4RY2A 4QBBA 2B1NA 3HWNA 2PNSA 3V6EA 2G8EA 3MORA 1NQCA 2FYEA 3IOQA 3U8EA 1W4TA 2FQ9A 4BPVA 3LFYA 4N8WA 4BS5A 4K7CA 1GX3A 3QT4A 2JQFR 1U9VA 4XR7A 2B1MA 4YYUA 1KHPA 2E03A 2R9FA 1EWOA 1TL9A 2NQAA 4OEMA 2YJBA 2DCAA 4MZOA 3OVZA 1CS8A 1PXVA 2HHNA 3ERVA 1U9QX 1BGOA 2DC9A 2IBIA 1QOLA 3LTWA 2DJGB 3K24A 1QMYA 4W5BA 9PAPA 2E00A 2AUZA 1BY8A 1DF0A 3O0UA 3HHIA 1GECE 2AIMA 4HWYA 4BGFA 1A6RA 1CV8A 2R9CA 1PCIA 2CIOA 4PP2E 1Y4HA 3H7DA 3BCNA 4FK5A 1F29A 3N3GA 1YK7A 3PDFA 1AIMA 2P0RA 1STFE 2F1GA 3QSDA 1AYWA 4C5PA 5J94A 1ME4A 3K8UA 3CBJA 3BOWA 2BDZA 3PBHA 3WXEA 2H7JA 1VJVA 2FUDA 2AVWA 3IEJA 3P5WA 3H6SA 4Q8HA 1CSBB 2PREA 1U5IA 2XU5A 4NV8A 4YYVA 1EWPA 2FTDA 3OVXA 2PADA 2AYOA 1MEGA 1W6FA 4BSQA 1QXPA 1VSNA 3AI8A 2FT2A 1AECA 1AU3A 8PCHA 3IHPA 5CHVA 1W5RA 5F02A 2FRAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FH0 A;  1U9W A;  1BP4 A;  5JH3 A;  5K16 A;  4KLB A;  2AS8 A;  4FIP A;  3MHS A;  2DCC A;  2R6N A;  4YYR A;  2DCB A;  2PBH A;  5CVN B;  1PE6 A;  2YJ8 A;  4AXL A;  1M6D A;  2FRQ A;  3IUT A;  1ME3 A;  1Y08 A;  4YYS A;  1U9X A;  1K3B B;  2VHS A;  1ICF A;  4X6J A;  4P6G A;  1NPZ A;  2HH5 A;  4PP1 A;  1TU6 A;  1O0E A;  4X6H A;  1AU2 A;  3OF9 A;  2P7U A;  4BS6 A;  3KFQ A;  4N4Z A;  1POP A;  3IV2 A;  4P6E A;  3RVX A;  1TLO A;  1DEU A;  1KHQ A;  4MSX A;  2DC8 A;  3KKU A;  2AU1 A;  3H8C A;  3RVV A;  5A24 A;  3OF8 A;  2E02 A;  5CHT A;  4ZUX U;  1GLO A;  2E01 A;  3D6S A;  3NHE A;  2GHU A;  4Q8G A;  3P5V A;  1BQI A;  4W4U A;  5FPW A;  1CTE A;  2BDL A;  5EGW A;  4OEL A;  2G8J A;  3CH2 X;  4G54 A;  4BQV A;  2YJC A;  3OIS A;  4QRG A;  1XKG A;  2OUL A;  3BPF A;  2ACT A;  4CDF B;  2R9O A;  3USV A;  4I04 A;  1PAD A;  3QJ3 A;  2JQG R;  2G7Y A;  4CDE B;  1GCB A;  1NLJ A;  1MEM A;  2YJ2 A;  1NB3 A;  3KW9 A;  2XU1 A;  3N3K A;  3B79 A;  3E1Z B;  3RVW A;  1F2B A;  1AU4 A;  3S3R A;  3GCB A;  3WXG A;  3O1G A;  4DMX A;  1QDQ A;  2NQG A;  3H89 A;  2VHF A;  5JA7 A;  3WXF A;  7PCK A;  1HUC B;  4QH6 A;  1EWL A;  2GFO A;  1KFU L;  2ARY A;  5CVO B;  3P5U A;  4QRX A;  2NQI A;  3V6C A;  4CDD B;  1F2C A;  4WA6 A;  3LXS A;  1EF7 A;  1YT7 A;  2DZY A;  1AU0 A;  2DC7 A;  2Y6E A;  2HD5 A;  3TNX A;  4N79 A;  5EF4 A;  3PNR A;  3CBK A;  3IMA A;  4MZS A;  2AUX A;  3I3T A;  4AXM A;  2DZZ A;  4YYW A;  3MHH A;  6PAD A;  2ATO A;  5PAD A;  1EWM A;  5CVM A;  2CB5 A;  3KX1 A;  4CZW A;  1PPD A;  1PPP A;  2F7D A;  1MIR A;  1ITO A;  1IWD A;  1CVZ A;  1MHW A;  1PBH A;  1S4V A;  2G6D A;  3BC3 A;  1PPO A;  2DJF B;  2XU3 A;  1AYU A;  2FO5 A;  4PAD A;  2NQD B;  1SP4 B;  1SNK A;  2HXZ A;  3H8B A;  2O6X A;  2AYN A;  2P86 A;  3KWB X;  1ZIV A;  1GMY A;  4I07 A;  3BPM A;  3MTN A;  4YYQ A;  4I05 A;  1F2A A;  2DC6 A;  3P5X A;  4FJC A;  2OP3 A;  4DMY A;  4XUI A;  4YVA A;  1PIP A;  1YAL A;  3KSE A;  1CB5 A;  1NL6 A;  2XU4 A;  4CDC B;  1MS6 A;  3BWK A;  1KXR A;  3M99 A;  2DCD A;  3K9M A;  3F75 A;  1ATK A;  4X6I A;  2R9M A;  1YK8 A;  3CH3 X;  2C0Y A;  1PPN A;  1AYV A;  1CPJ A;  2R9N A;  4QRV A;  4W5C A;  4PI3 A;  1THE A;  3N4C A;  3KWZ A;  3HHA A;  3S3Q A;  2OZ2 A;  2YJ9 A;  2WBF X;  3PW3 A;  2IPP B;  3I06 A;  1ZCM A;  4YV8 A;  1X9Y A;  3C9E A;  3HD3 A;  1KFX L;  3ZUA A;  1JQP A;  1Q6K A;  1CJL A;  3F5V A;  1YVB A;  1MDW A;  1CQD A;  3DF0 A;  1NB5 A;  2Y5B A;  4RY2 A;  4QBB A;  2B1N A;  3HWN A;  2PNS A;  3V6E A;  2G8E A;  3MOR A;  1NQC A;  2FYE A;  3IOQ A;  3U8E A;  2FQ9 A;  4BPV A;  3LFY A;  4N8W A;  4BS5 A;  4K7C A;  3QT4 A;  2JQF R;  1U9V A;  4XR7 A;  2B1M A;  4YYU A;  1KHP A;  2E03 A;  2R9F A;  1EWO A;  1TL9 A;  2NQA A;  4OEM A;  2YJB A;  2DCA A;  4MZO A;  3OVZ A;  1CS8 A;  1PXV A;  2HHN A;  3ERV A;  1U9Q X;  1BGO A;  2DC9 A;  2IBI A;  1QOL A;  2DJG B;  3K24 A;  1QMY A;  4W5B A;  9PAP A;  2E00 A;  2AUZ A;  1BY8 A;  1DF0 A;  3O0U A;  3HHI A;  1GEC E;  2AIM A;  4HWY A;  1A6R A;  1CV8 A;  2R9C A;  1PCI A;  2CIO A;  4PP2 E;  1Y4H A;  3H7D A;  3BCN A;  4FK5 A;  1F29 A;  3N3G A;  1YK7 A;  3PDF A;  1AIM A;  2P0R A;  1STF E;  2F1G A;  3QSD A;  1AYW A;  5J94 A;  1ME4 A;  3K8U A;  3CBJ A;  3BOW A;  2BDZ A;  3PBH A;  3WXE A;  2H7J A;  1VJV A;  2FUD A;  2AVW A;  3IEJ A;  3P5W A;  3H6S A;  4Q8H A;  1CSB B;  2PRE A;  1U5I A;  2XU5 A;  4YYV A;  1EWP A;  2FTD A;  3OVX A;  2PAD A;  2AYO A;  1MEG A;  4BSQ A;  1QXP A;  1VSN A;  3AI8 A;  2FT2 A;  1AEC A;  1AU3 A;  8PCH A;  3IHP A;  5CHV A;  5F02 A;  2FRA A; 
#chains in the Genus database with same CATH topology
 1FH0 A;  1U9W A;  1BP4 A;  5JH3 A;  5K16 A;  2AGA A;  4KLB A;  2AS8 A;  4FIP A;  1PVJ A;  3MHS A;  2DCC A;  2R6N A;  4YYR A;  2DCB A;  2PBH A;  5CVN B;  1PE6 A;  3TRK A;  2JTC A;  2YJ8 A;  4AXL A;  1M6D A;  3PHW A;  2FRQ A;  3IUT A;  1ME3 A;  1Y08 A;  4YYS A;  1U9X A;  1K3B B;  4IP3 A;  2VHS A;  1ICF A;  4X6J A;  4P6G A;  1NPZ A;  2HH5 A;  4PP1 A;  1TU6 A;  1O0E A;  4X6H A;  1AU2 A;  3OF9 A;  2P7U A;  4BS6 A;  4RF1 A;  3KFQ A;  1UKF A;  4N4Z A;  1POP A;  3IV2 A;  4P6E A;  3RVX A;  1TLO A;  1DEU A;  1KHQ A;  4MSX A;  2DC8 A;  3KKU A;  2AU1 A;  3H8C A;  3RVV A;  5A24 A;  3OF8 A;  2E02 A;  5CHT A;  4MI7 A;  4ZUX U;  1GLO A;  2E01 A;  3D6S A;  3NHE A;  2GHU A;  4Q8G A;  3P5V A;  1BQI A;  4W4U A;  3OQC A;  5FPW A;  2Z84 A;  1CTE A;  4ZTB A;  2BDL A;  5EGW A;  4OEL A;  2G8J A;  3CH2 X;  4G54 A;  3PRM A;  4BQV A;  2YJC A;  3OIS A;  4QRG A;  3RNV A;  1XKG A;  2OUL A;  3BPF A;  3TMP A;  2ACT A;  4CDF B;  4D8B A;  3E9S A;  2R9O A;  3USV A;  4I04 A;  4OW0 A;  5E6J A;  1PAD A;  3QJ3 A;  4RNA A;  2JQG R;  2G7Y A;  4CDE B;  1GCB A;  4M0W A;  1NLJ A;  1MEM A;  2YJ2 A;  1NB3 A;  3KW9 A;  3W30 A;  2XU1 A;  3N3K A;  3B79 A;  3E1Z B;  3RVW A;  1F2B A;  1AU4 A;  3S3R A;  3GCB A;  3WXG A;  3O1G A;  4DMX A;  1QDQ A;  3BBA A;  2NQG A;  3H89 A;  2VHF A;  2UZJ A;  5JA7 A;  3WXF A;  7PCK A;  4REZ A;  1HUC B;  4QH6 A;  1EWL A;  2GFO A;  1KFU L;  4GUA A;  2ARY A;  5CVO B;  3P5U A;  4QRX A;  3W31 A;  2NQI A;  3V6C A;  4CDD B;  1F2C A;  4WA6 A;  3LXS A;  3PT2 A;  1EF7 A;  1YT7 A;  2DZY A;  1AU0 A;  2DC7 A;  2Y6E A;  2HD5 A;  3TNX A;  4D8I A;  4N79 A;  5EF4 A;  3PNR A;  3CBK A;  3IMA A;  4MZS A;  3BY4 A;  2AUX A;  4IUM A;  3I3T A;  4AXM A;  5EZQ A;  4R3D A;  2J7Q A;  2DZZ A;  4YYW A;  3MHH A;  6PAD A;  2ATO A;  2HWK A;  5PAD A;  1EWM A;  5CVM A;  2CB5 A;  3KX1 A;  2J7Q C;  4WUR A;  4CZW A;  1PPD A;  1PPP A;  2F7D A;  1MIR A;  4RF0 A;  1ITO A;  1IWD A;  1CVZ A;  1MHW A;  1PBH A;  1S4V A;  2G6D A;  3MJ5 A;  3BC3 A;  1PPO A;  2DJF B;  2XU3 A;  1AYU A;  2FO5 A;  4PAD A;  2NQD B;  1SP4 B;  1SNK A;  2HXZ A;  3H8B A;  2O6X A;  2AYN A;  2P86 A;  1DKI A;  3KWB X;  1ZIV A;  4D8E A;  1GMY A;  4I07 A;  4MM3 B;  3BPM A;  3MTN A;  4YYQ A;  4RKX A;  4I05 A;  1F2A A;  2DC6 A;  3P5X A;  2BTW B;  4FJC A;  2OP3 A;  4DMY A;  4XUI A;  4YVA A;  1PIP A;  1YAL A;  3KSE A;  4XZX A;  1CB5 A;  1NL6 A;  3BB7 A;  2XU4 A;  4CDC B;  4OVZ B;  1MS6 A;  3BWK A;  1KXR A;  3MTV A;  3M99 A;  2DCD A;  3K9M A;  3F75 A;  1ATK A;  4X6I A;  3PRP A;  4BOU A;  2R9M A;  1YK8 A;  3CH3 X;  2C0Y A;  1PPN A;  1AYV A;  1CPJ A;  2R9N A;  4QRV A;  4W5C A;  4PI3 A;  5JZE A;  1THE A;  3N4C A;  3KWZ A;  3HHA A;  3S3Q A;  2FE8 A;  3PHU A;  2OZ2 A;  2YJ9 A;  2WBF X;  3PW3 A;  2IPP B;  3I06 A;  1ZCM A;  4BOP A;  4YV8 A;  1X9Y A;  3C9E A;  3HD3 A;  4A5U A;  1KFX L;  3ZUA A;  2BTW A;  1JQP A;  1Q6K A;  1CJL A;  3F5V A;  1YVB A;  1MDW A;  1CQD A;  3DF0 A;  1NB5 A;  3C0R A;  2Y5B A;  4RY2 A;  4QBB A;  4OVZ A;  2B1N A;  3HWN A;  3O65 A;  2PNS A;  3V6E A;  4BOS A;  3IFU A;  2G8E A;  3MOR A;  1NQC A;  2FYE A;  3IOQ A;  3U8E A;  4P16 A;  2FQ9 A;  4BPV A;  3LFY A;  4N8W A;  4BS5 A;  4K7C A;  3QT4 A;  2JQF R;  1U9V A;  4XR7 A;  2B1M A;  4YYU A;  1KHP A;  2E03 A;  2R9F A;  3MP2 A;  1EWO A;  1TL9 A;  2NQA A;  4OEM A;  2YJB A;  2DCA A;  4MZO A;  3OVZ A;  1CS8 A;  1PXV A;  2HHN A;  3ERV A;  1U9Q X;  1BGO A;  2DC9 A;  2IBI A;  1QOL A;  2DJG B;  3K24 A;  1QMY A;  4W5B A;  2BU3 A;  2DOS A;  9PAP A;  2E00 A;  2AUZ A;  1BY8 A;  1DF0 A;  4BOZ A;  3O0U A;  3HHI A;  1GEC E;  2AIM A;  4HXD B;  4HWY A;  1A6R A;  1CV8 A;  2R9C A;  1PCI A;  3ZNH A;  2CIO A;  4PP2 E;  1Y4H A;  3H7D A;  3BCN A;  5EZS A;  4FK5 A;  1F29 A;  3N3G A;  1YK7 A;  3PDF A;  1AIM A;  4PT5 A;  2P0R A;  1YZB A;  3PSE A;  1STF E;  2F1G A;  3QSD A;  3B21 A;  1AYW A;  5J94 A;  3PHX A;  1ME4 A;  3K8U A;  3CBJ A;  3BOW A;  2BDZ A;  3PBH A;  3WXE A;  2H7J A;  1VJV A;  2FUD A;  2JRI A;  2AVW A;  3IEJ A;  3P5W A;  3H6S A;  4Q8H A;  1CSB B;  2PRE A;  1U5I A;  2XU5 A;  4YYV A;  1EWP A;  2FTD A;  3OVX A;  2PAD A;  2AYO A;  1MEG A;  4BSQ A;  1QXP A;  1VSN A;  3AI8 A;  2FT2 A;  5KO3 A;  4BOQ A;  1AEC A;  1AU3 A;  8PCH A;  3IHP A;  5CHV A;  5F02 A;  2FRA A; 
#chains in the Genus database with same CATH homology
 1FH0 A;  1U9W A;  1BP4 A;  5JH3 A;  5K16 A;  4KLB A;  2AS8 A;  4FIP A;  3MHS A;  2DCC A;  2R6N A;  4YYR A;  2DCB A;  2PBH A;  5CVN B;  1PE6 A;  2YJ8 A;  4AXL A;  1M6D A;  2FRQ A;  3IUT A;  1ME3 A;  1Y08 A;  4YYS A;  1U9X A;  1K3B B;  2VHS A;  1ICF A;  4X6J A;  4P6G A;  1NPZ A;  2HH5 A;  4PP1 A;  1TU6 A;  1O0E A;  4X6H A;  1AU2 A;  3OF9 A;  2P7U A;  4BS6 A;  3KFQ A;  4N4Z A;  1POP A;  3IV2 A;  4P6E A;  3RVX A;  1TLO A;  1DEU A;  1KHQ A;  4MSX A;  2DC8 A;  3KKU A;  2AU1 A;  3H8C A;  3RVV A;  5A24 A;  3OF8 A;  2E02 A;  5CHT A;  4ZUX U;  1GLO A;  2E01 A;  3D6S A;  3NHE A;  2GHU A;  4Q8G A;  3P5V A;  1BQI A;  4W4U A;  5FPW A;  1CTE A;  4GUZ A;  2BDL A;  5EGW A;  4OEL A;  2G8J A;  3CH2 X;  4G54 A;  4BQV A;  2YJC A;  3OIS A;  4QRG A;  1XKG A;  2OUL A;  3BPF A;  2ACT A;  4CDF B;  2R9O A;  3USV A;  4I04 A;  4B55 A;  1PAD A;  3QJ3 A;  2JQG R;  2G7Y A;  4CDE B;  1GCB A;  1NLJ A;  1MEM A;  4NV7 A;  2YJ2 A;  1NB3 A;  3KW9 A;  2XU1 A;  3N3K A;  3B79 A;  3E1Z B;  3RVW A;  1F2B A;  1AU4 A;  3S3R A;  3GCB A;  3WXG A;  3O1G A;  4DMX A;  1QDQ A;  2NQG A;  3H89 A;  2VHF A;  5JA7 A;  3WXF A;  7PCK A;  1HUC B;  4QH6 A;  1EWL A;  3D9W A;  2GFO A;  1KFU L;  2ARY A;  5CVO B;  3P5U A;  4QRX A;  2NQI A;  3V6C A;  4CDD B;  1F2C A;  4WA6 A;  3LXS A;  1EF7 A;  1YT7 A;  2DZY A;  1AU0 A;  2DC7 A;  2VFC A;  2Y6E A;  2HD5 A;  3TNX A;  2VFB A;  4N79 A;  5EF4 A;  3PNR A;  3CBK A;  3IMA A;  4MZS A;  2AUX A;  3I3T A;  4AXM A;  2DZZ A;  4YYW A;  3MHH A;  6PAD A;  2ATO A;  5PAD A;  1EWM A;  5CVM A;  2CB5 A;  3KX1 A;  4CZW A;  1PPD A;  1PPP A;  2F7D A;  1MIR A;  1E2T A;  1ITO A;  1IWD A;  1CVZ A;  1MHW A;  1PBH A;  1S4V A;  2G6D A;  3BC3 A;  1PPO A;  2DJF B;  2XU3 A;  1AYU A;  2FO5 A;  4PAD A;  2NQD B;  1SP4 B;  1SNK A;  2HXZ A;  3H8B A;  2O6X A;  2AYN A;  2P86 A;  3KWB X;  1ZIV A;  1GMY A;  4I07 A;  3BPM A;  3MTN A;  4YYQ A;  4I05 A;  1F2A A;  2DC6 A;  3P5X A;  4FJC A;  2OP3 A;  4DMY A;  4XUI A;  4YVA A;  1PIP A;  1YAL A;  3KSE A;  1CB5 A;  1NL6 A;  2XU4 A;  4CDC B;  1MS6 A;  3BWK A;  1KXR A;  3M99 A;  2DCD A;  3K9M A;  3F75 A;  1ATK A;  4X6I A;  2BSZ A;  2R9M A;  1YK8 A;  3CH3 X;  2C0Y A;  1PPN A;  1AYV A;  1CPJ A;  2R9N A;  4QRV A;  4W5C A;  4PI3 A;  1THE A;  3N4C A;  3KWZ A;  3HHA A;  3S3Q A;  2OZ2 A;  2YJ9 A;  2WBF X;  3PW3 A;  2IPP B;  3I06 A;  1ZCM A;  4YV8 A;  1X9Y A;  3C9E A;  3HD3 A;  1KFX L;  3ZUA A;  1JQP A;  1Q6K A;  1CJL A;  3F5V A;  1YVB A;  1MDW A;  1CQD A;  3DF0 A;  1NB5 A;  2Y5B A;  4RY2 A;  4QBB A;  2B1N A;  3HWN A;  2PNS A;  3V6E A;  2G8E A;  3MOR A;  1NQC A;  2FYE A;  3IOQ A;  3U8E A;  1W4T A;  2FQ9 A;  4BPV A;  3LFY A;  4N8W A;  4BS5 A;  4K7C A;  1GX3 A;  3QT4 A;  2JQF R;  1U9V A;  4XR7 A;  2B1M A;  4YYU A;  1KHP A;  2E03 A;  2R9F A;  1EWO A;  1TL9 A;  2NQA A;  4OEM A;  2YJB A;  2DCA A;  4MZO A;  3OVZ A;  1CS8 A;  1PXV A;  2HHN A;  3ERV A;  1U9Q X;  1BGO A;  2DC9 A;  2IBI A;  1QOL A;  3LTW A;  2DJG B;  3K24 A;  1QMY A;  4W5B A;  9PAP A;  2E00 A;  2AUZ A;  1BY8 A;  1DF0 A;  3O0U A;  3HHI A;  1GEC E;  2AIM A;  4HWY A;  4BGF A;  1A6R A;  1CV8 A;  2R9C A;  1PCI A;  2CIO A;  4PP2 E;  1Y4H A;  3H7D A;  3BCN A;  4FK5 A;  1F29 A;  3N3G A;  1YK7 A;  3PDF A;  1AIM A;  2P0R A;  1STF E;  2F1G A;  3QSD A;  1AYW A;  4C5P A;  5J94 A;  1ME4 A;  3K8U A;  3CBJ A;  3BOW A;  2BDZ A;  3PBH A;  3WXE A;  2H7J A;  1VJV A;  2FUD A;  2AVW A;  3IEJ A;  3P5W A;  3H6S A;  4Q8H A;  1CSB B;  2PRE A;  1U5I A;  2XU5 A;  4NV8 A;  4YYV A;  1EWP A;  2FTD A;  3OVX A;  2PAD A;  2AYO A;  1MEG A;  1W6F A;  4BSQ A;  1QXP A;  1VSN A;  3AI8 A;  2FT2 A;  1AEC A;  1AU3 A;  8PCH A;  3IHP A;  5CHV A;  1W5R A;  5F02 A;  2FRA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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