3OF8A

Structural basis for reversible and irreversible inhibition of human cathepsin l by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
221
structure length
221
Chain Sequence
EAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Cathepsin L1
publication title Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 67
structure length 221
sequence length 221
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2010-08-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3of8A00
2YJBA 1JQPA 1FH0A 3KFQA 3MTNA 3P5UA 2H7JA 5JA7A 1F2BA 2P7UA 9PAPA 1U9XA 3WXFA 1SP4B 5CHVA 3F75A 1NB3A 3IUTA 2OZ2A 3KWZA 4I04A 1DF0A 3H7DA 2R9CA 3KWBX 1EF7A 1ME3A 1NPZA 3QT4A 1TLOA 1KFUL 2OP3A 4CDDB 3HHAA 4N4ZA 1Y08A 2DCDA 2ARYA 2GFOA 3K8UA 3H89A 4CZWA 1CSBB 3OF9A 3B79A 5EGWA 4QH6A 1U9QX 1GMYA 3RVWA 2G7YA 1ZIVA 2NQDB 1PPOA 4OELA 2CB5A 3OF8A 2AUZA 3MORA 2P0RA 1CPJA 3I3TA 1AU3A 3WXEA 2JQGR 1PIPA 3BC3A 4XR7A 1VSNA 2E03A 2P86A 4HWYA 1XKGA 1U5IA 4FIPA 2FT2A 3V6EA 2HD5A 4PI3A 2DCAA 2O6XA 5J94A 3USVA 1NB5A 3OISA 8PCHA 4BQVA 4N8WA 2R9FA 1ITOA 2XU5A 5F02A 1QMYA 4RY2A 2FO5A 3P5WA 2AU1A 2R9NA 3O0UA 3LFYA 1F2AA 4BPVA 1U9WA 3N4CA 4DMXA 1YK8A 1PPNA 1BGOA 2F1GA 3HD3A 2DCCA 3ERVA 3H8BA 2E01A 2FTDA 2DC8A 2ACTA 4X6HA 3ZUAA 1VJVA 1CVZA 4YYQA 3IEJA 4MZSA 3F5VA 4CDEB 2JQFR 4N79A 3OVXA 4P6EA 2ATOA 2FRAA 1IWDA 4I05A 1ATKA 1NL6A 3PDFA 2VHFA 1GLOA 2G8JA 3HWNA 1BQIA 2YJ2A 4FK5A 2YJ8A 5FPWA 4PP2E 3CBJA 3OVZA 1POPA 2HHNA 3IOQA 1AYVA 3IV2A 1X9YA 2Y6EA 1AYUA 2G8EA 4PP1A 1CV8A 5JH3A 1GCBA 3K24A 3BOWA 5CHTA 4G54A 4YYRA 1M6DA 2GHUA 2XU3A 2E02A 1SNKA 3KX1A 4W4UA 2DC6A 2DC7A 3V6CA 4BS5A 2XU4A 3N3KA 2DZYA 7PCKA 2AUXA 2PNSA 1TU6A 4YV8A 1TL9A 3CH3X 2WBFX 1PE6A 2F7DA 2FRQA 2DJGB 2NQGA 1ZCMA 4QRXA 3MHHA 1CB5A 1EWOA 4DMYA 2NQAA 3QJ3A 3C9EA 2FYEA 4P6GA 3RVXA 3CBKA 4YYVA 1HUCB 1EWMA 1MDWA 1PXVA 5A24A 1CJLA 3U8EA 1A6RA 3IMAA 1AECA 2C0YA 1U9VA 1NQCA 1EWPA 1KHPA 4YVAA 4PADA 3E1ZB 4X6JA 3K9MA 1F2CA 1STFE 2BDLA 1BP4A 5CVMA 1MIRA 2AS8A 3QSDA 4X6IA 1ME4A 3I06A 1GECE 2HH5A 1PADA 1Y4HA 1DEUA 2VHSA 3RVVA 2B1NA 2G6DA 2XU1A 2YJCA 3KKUA 5K16A 4W5CA 1AU0A 2AVWA 2BDZA 3DF0A 3H6SA 4CDFB 1MEGA 3PBHA 3BWKA 4QRGA 4FJCA 1NLJA 4ZUXU 2R6NA 4YYWA 2OULA 2E00A 4QBBA 2PADA 1BY8A 4YYSA 2DCBA 3MHSA 2DZZA 1QDQA 3KSEA 3P5XA 2IBIA 1YALA 1CS8A 1PBHA 3AI8A 3KW9A 2IPPB 1AYWA 4MZOA 1CQDA 2AYOA 2PREA 1EWLA 2YJ9A 1YVBA 1YT7A 3P5VA 3LXSA 1Q6KA 4I07A 1K3BB 4BSQA 4QRVA 5PADA 3M99A 1PPDA 2DC9A 1O0EA 1YK7A 2NQIA 1CTEA 2PBHA 1S4VA 3TNXA 4AXLA 2FQ9A 1QXPA 3D6SA 3GCBA 1KXRA 1ICFA 1PPPA 1AU4A 3H8CA 3PNRA 3BPFA 1AIMA 3N3GA 1QOLA 2B1MA 4KLBA 2HXZA 2R9OA 3NHEA 1MEMA 4OEMA 3O1GA 1KFXL 4CDCB 1KHQA 2R9MA 3WXGA 1MHWA 4Q8HA 2FUDA 2CIOA 3BCNA 2AYNA 5EF4A 3CH2X 1MS6A 1AU2A 2AIMA 4YYUA 4Q8GA 2DJFB 5CVNB 6PADA 4XUIA 4MSXA 4WA6A 3IHPA 1THEA 3PW3A 1PCIA 3S3RA 4K7CA 3BPMA 5CVOB 4AXMA 3S3QA 1F29A 3HHIA 4BS6A 4W5BA 2Y5BA
chains in the Genus database with same CATH superfamily
2YJBA 1JQPA 1FH0A 3KFQA 3MTNA 5KO3A 3P5UA 2H7JA 5JA7A 1F2BA 2P7UA 9PAPA 1U9XA 3WXFA 1SP4B 5CHVA 3F75A 1NB3A 3IUTA 3MP2A 2OZ2A 3KWZA 4I04A 4RF0A 1DF0A 4PT5A 3H7DA 2R9CA 3KWBX 4MM3B 1EF7A 1ME3A 1NPZA 3QT4A 4OVZA 1UKFA 1TLOA 3BBAA 1KFUL 2OP3A 4CDDB 3HHAA 4N4ZA 1Y08A 2DCDA 2ARYA 2GFOA 3K8UA 3H89A 4CZWA 4RKXA 1CSBB 3OF9A 3B79A 5EGWA 3C0RA 4QH6A 1U9QX 1GMYA 3RVWA 5JZEA 2G7YA 1ZIVA 2NQDB 1PPOA 4OELA 2CB5A 3OF8A 2AUZA 3MORA 2P0RA 1CPJA 1DKIA 3I3TA 1AU3A 2JRIA 3WXEA 2JQGR 1PIPA 3BC3A 4P16A 4XR7A 1VSNA 2E03A 2P86A 4HWYA 1XKGA 1U5IA 2BTWA 4A5UA 4FIPA 2FT2A 3V6EA 2HD5A 2DCAA 2O6XA 4PI3A 5J94A 3USVA 1NB5A 3OISA 8PCHA 2J7QC 4BQVA 4N8WA 2R9FA 1ITOA 2XU5A 5F02A 1QMYA 2AGAA 4RY2A 2FO5A 3P5WA 2AU1A 2R9NA 3O0UA 3LFYA 1F2AA 4BPVA 1U9WA 3N4CA 4DMXA 1YK8A 1PPNA 1BGOA 2F1GA 3HD3A 2DCCA 3ERVA 3H8BA 2E01A 2FTDA 3BY4A 2DC8A 2ACTA 4X6HA 3ZUAA 1VJVA 1CVZA 4YYQA 3IEJA 4MZSA 3F5VA 4CDEB 2JQFR 4N79A 2BU3A 3OVXA 4P6EA 5EZQA 2ATOA 2FRAA 1IWDA 4I05A 1ATKA 1NL6A 3PDFA 4M0WA 2VHFA 1GLOA 2G8JA 3HWNA 1BQIA 2YJ2A 4FK5A 3W31A 3PRMA 2YJ8A 5FPWA 3IFUA 4REZA 4BOUA 4PP2E 1PVJA 3CBJA 3OVZA 1POPA 2HHNA 3IOQA 1AYVA 3IV2A 1X9YA 2Y6EA 1AYUA 2G8EA 5E6JA 4PP1A 1CV8A 5JH3A 2Z84A 1GCBA 3K24A 3BOWA 4XZXA 5CHTA 4G54A 4YYRA 1M6DA 2GHUA 2J7QA 2XU3A 2E02A 1SNKA 3KX1A 4W4UA 2DC6A 2DC7A 3V6CA 4BS5A 2XU4A 3N3KA 2DZYA 3RNVA 7PCKA 2AUXA 2PNSA 1TU6A 4YV8A 1TL9A 3CH3X 2WBFX 3B21A 1PE6A 3E9SA 2F7DA 2FRQA 2DJGB 2NQGA 1ZCMA 4QRXA 3MHHA 1CB5A 1EWOA 4DMYA 2NQAA 3QJ3A 3C9EA 2FYEA 4P6GA 3RVXA 3CBKA 4YYVA 1HUCB 1EWMA 1MDWA 1PXVA 5A24A 1CJLA 3PT2A 3U8EA 1A6RA 3IMAA 1AECA 2C0YA 3PHWA 1U9VA 4IP3A 4D8IA 4ZTBA 1NQCA 3PHXA 1EWPA 4BOZA 1KHPA 4YVAA 3TMPA 3W30A 4PADA 3E1ZB 4X6JA 3K9MA 1F2CA 1STFE 2FE8A 2BDLA 1BP4A 5CVMA 1MIRA 3O65A 2AS8A 3QSDA 4X6IA 1ME4A 3I06A 1GECE 2HH5A 1PADA 1Y4HA 4OW0A 1DEUA 2VHSA 3RVVA 2B1NA 2G6DA 2DOSA 2XU1A 3MTVA 2YJCA 3KKUA 5K16A 4W5CA 1AU0A 2AVWA 2BDZA 3DF0A 3H6SA 4CDFB 4BOPA 1MEGA 4BOSA 1YZBA 3PBHA 3BWKA 4QRGA 4FJCA 1NLJA 4ZUXU 2R6NA 4YYWA 2OULA 2E00A 4QBBA 2PADA 1BY8A 4YYSA 2DCBA 3MHSA 2DZZA 4HXDB 1QDQA 4D8EA 3KSEA 3P5XA 2IBIA 1YALA 1CS8A 1PBHA 3AI8A 3KW9A 2IPPB 1AYWA 4D8BA 3PSEA 4MZOA 1CQDA 2AYOA 2PREA 1EWLA 2YJ9A 1YVBA 4MI7A 1YT7A 3P5VA 3LXSA 1Q6KA 4I07A 1K3BB 4BSQA 4OVZB 4QRVA 5PADA 3M99A 1PPDA 2DC9A 1O0EA 1YK7A 2NQIA 1CTEA 2PBHA 1S4VA 3TNXA 3PRPA 4AXLA 2FQ9A 2HWKA 1QXPA 3D6SA 3BB7A 3GCBA 5EZSA 1KXRA 1ICFA 1PPPA 1AU4A 3H8CA 3PNRA 3BPFA 1AIMA 4GUAA 3N3GA 3ZNHA 1QOLA 2JTCA 2B1MA 4KLBA 4BOQA 3OQCA 2HXZA 2R9OA 3NHEA 1MEMA 4OEMA 3O1GA 1KFXL 4CDCB 1KHQA 2R9MA 3PHUA 3WXGA 3MJ5A 1MHWA 4Q8HA 2FUDA 2CIOA 4R3DA 3BCNA 2AYNA 5EF4A 3CH2X 1MS6A 2BTWB 1AU2A 2AIMA 4YYUA 4Q8GA 2DJFB 4IUMA 5CVNB 6PADA 4RNAA 4XUIA 4MSXA 4WA6A 3IHPA 4RF1A 2UZJA 1THEA 3PW3A 1PCIA 3S3RA 4K7CA 3BPMA 5CVOB 3TRKA 4WURA 4AXMA 3S3QA 1F29A 3HHIA 4BS6A 4W5BA 2Y5BA
chains in the Genus database with same CATH topology
2YJBA 1JQPA 1FH0A 3KFQA 3MTNA 3P5UA 2H7JA 5JA7A 1F2BA 2P7UA 1W5RA 9PAPA 1U9XA 3WXFA 1SP4B 5CHVA 3F75A 3LTWA 1NB3A 3IUTA 2OZ2A 3KWZA 4I04A 1DF0A 3H7DA 2R9CA 3KWBX 1EF7A 1ME3A 1NPZA 3QT4A 1TLOA 1KFUL 2OP3A 4CDDB 3HHAA 4N4ZA 1Y08A 2DCDA 2ARYA 2GFOA 3K8UA 3H89A 4CZWA 1CSBB 3OF9A 3B79A 5EGWA 4QH6A 1U9QX 1GMYA 3RVWA 2G7YA 1ZIVA 2NQDB 1PPOA 4OELA 2CB5A 3OF8A 2AUZA 3MORA 2P0RA 1CPJA 2BSZA 3I3TA 1AU3A 3WXEA 2JQGR 1PIPA 3BC3A 4XR7A 1VSNA 2E03A 2P86A 4HWYA 1XKGA 1U5IA 4FIPA 2FT2A 3V6EA 2HD5A 2DCAA 2O6XA 4PI3A 5J94A 3USVA 1NB5A 3OISA 8PCHA 4BQVA 4N8WA 2R9FA 1ITOA 2XU5A 1W6FA 5F02A 1QMYA 4RY2A 2FO5A 3P5WA 2AU1A 2R9NA 3O0UA 3LFYA 1F2AA 4BPVA 1U9WA 3N4CA 4DMXA 1YK8A 1PPNA 1BGOA 2F1GA 3HD3A 2DCCA 3ERVA 3H8BA 2E01A 2FTDA 2DC8A 2ACTA 4X6HA 3ZUAA 1VJVA 1CVZA 4YYQA 4C5PA 3IEJA 4MZSA 3F5VA 4CDEB 4NV8A 2JQFR 4N79A 3OVXA 4P6EA 2ATOA 2FRAA 1IWDA 4I05A 1ATKA 1NL6A 3PDFA 2VHFA 1GLOA 2G8JA 3HWNA 1BQIA 2YJ2A 4FK5A 2YJ8A 5FPWA 4GUZA 4PP2E 3CBJA 3OVZA 1POPA 2HHNA 3IOQA 1AYVA 3IV2A 1X9YA 2Y6EA 1AYUA 2G8EA 4PP1A 1CV8A 5JH3A 1GCBA 3K24A 3BOWA 5CHTA 4G54A 4YYRA 1M6DA 2GHUA 2XU3A 2E02A 1W4TA 1SNKA 3KX1A 4W4UA 2DC6A 2DC7A 3V6CA 4BS5A 2XU4A 3N3KA 2DZYA 7PCKA 2AUXA 2PNSA 1TU6A 4YV8A 1TL9A 3CH3X 2WBFX 1PE6A 2F7DA 2FRQA 2DJGB 2NQGA 1GX3A 1ZCMA 4QRXA 3MHHA 1CB5A 1EWOA 4DMYA 2NQAA 3QJ3A 3C9EA 2FYEA 4P6GA 3RVXA 3D9WA 3CBKA 4YYVA 1HUCB 1EWMA 1MDWA 1PXVA 5A24A 1CJLA 3U8EA 1A6RA 3IMAA 1AECA 2C0YA 1U9VA 1NQCA 1EWPA 1KHPA 4YVAA 2VFBA 4PADA 3E1ZB 4X6JA 3K9MA 4BGFA 1F2CA 1STFE 2BDLA 1E2TA 1BP4A 5CVMA 1MIRA 2AS8A 3QSDA 4X6IA 1ME4A 3I06A 1GECE 2HH5A 1PADA 1Y4HA 1DEUA 2VHSA 3RVVA 2B1NA 2G6DA 2XU1A 2YJCA 3KKUA 5K16A 4W5CA 1AU0A 2AVWA 2BDZA 3DF0A 3H6SA 4CDFB 1MEGA 3PBHA 3BWKA 4QRGA 4FJCA 1NLJA 2VFCA 2R6NA 4ZUXU 4YYWA 2OULA 2E00A 4QBBA 2PADA 1BY8A 4YYSA 2DCBA 3MHSA 2DZZA 1QDQA 3KSEA 3P5XA 2IBIA 1YALA 1CS8A 1PBHA 3AI8A 3KW9A 2IPPB 1AYWA 4MZOA 1CQDA 2AYOA 2PREA 1EWLA 2YJ9A 1YVBA 4NV7A 1YT7A 3P5VA 3LXSA 1Q6KA 4I07A 1K3BB 4BSQA 4QRVA 5PADA 3M99A 1PPDA 2DC9A 1O0EA 1YK7A 2NQIA 1CTEA 2PBHA 1S4VA 3TNXA 4AXLA 2FQ9A 1QXPA 3D6SA 3GCBA 1KXRA 1ICFA 1PPPA 1AU4A 3H8CA 3PNRA 3BPFA 1AIMA 3N3GA 1QOLA 2B1MA 4KLBA 2HXZA 2R9OA 3NHEA 1MEMA 4OEMA 3O1GA 1KFXL 4CDCB 1KHQA 2R9MA 3WXGA 1MHWA 4Q8HA 2FUDA 2CIOA 3BCNA 2AYNA 5EF4A 3CH2X 1MS6A 1AU2A 2AIMA 4YYUA 4Q8GA 2DJFB 5CVNB 4B55A 6PADA 4XUIA 4MSXA 4WA6A 3IHPA 1THEA 3PW3A 1PCIA 3S3RA 4K7CA 3BPMA 5CVOB 4AXMA 3S3QA 1F29A 3HHIA 4BS6A 4W5BA 2Y5BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YJB A;  1JQP A;  1FH0 A;  3KFQ A;  3MTN A;  3P5U A;  2H7J A;  5JA7 A;  1F2B A;  2P7U A;  9PAP A;  1U9X A;  3WXF A;  1SP4 B;  5CHV A;  3F75 A;  1NB3 A;  3IUT A;  2OZ2 A;  3KWZ A;  4I04 A;  1DF0 A;  3H7D A;  2R9C A;  3KWB X;  1EF7 A;  1ME3 A;  1NPZ A;  3QT4 A;  1TLO A;  1KFU L;  2OP3 A;  4CDD B;  3HHA A;  4N4Z A;  1Y08 A;  2DCD A;  2ARY A;  2GFO A;  3K8U A;  3H89 A;  4CZW A;  1CSB B;  3OF9 A;  3B79 A;  5EGW A;  4QH6 A;  1U9Q X;  1GMY A;  3RVW A;  2G7Y A;  1ZIV A;  2NQD B;  1PPO A;  4OEL A;  2CB5 A;  3OF8 A;  2AUZ A;  3MOR A;  2P0R A;  1CPJ A;  3I3T A;  1AU3 A;  3WXE A;  2JQG R;  1PIP A;  3BC3 A;  4XR7 A;  1VSN A;  2E03 A;  2P86 A;  4HWY A;  1XKG A;  1U5I A;  4FIP A;  2FT2 A;  3V6E A;  2HD5 A;  4PI3 A;  2DCA A;  2O6X A;  5J94 A;  3USV A;  1NB5 A;  3OIS A;  8PCH A;  4BQV A;  4N8W A;  2R9F A;  1ITO A;  2XU5 A;  5F02 A;  1QMY A;  4RY2 A;  2FO5 A;  3P5W A;  2AU1 A;  2R9N A;  3O0U A;  3LFY A;  1F2A A;  4BPV A;  1U9W A;  3N4C A;  4DMX A;  1YK8 A;  1PPN A;  1BGO A;  2F1G A;  3HD3 A;  2DCC A;  3ERV A;  3H8B A;  2E01 A;  2FTD A;  2DC8 A;  2ACT A;  4X6H A;  3ZUA A;  1VJV A;  1CVZ A;  4YYQ A;  3IEJ A;  4MZS A;  3F5V A;  4CDE B;  2JQF R;  4N79 A;  3OVX A;  4P6E A;  2ATO A;  2FRA A;  1IWD A;  4I05 A;  1ATK A;  1NL6 A;  3PDF A;  2VHF A;  1GLO A;  2G8J A;  3HWN A;  1BQI A;  2YJ2 A;  4FK5 A;  2YJ8 A;  5FPW A;  4PP2 E;  3CBJ A;  3OVZ A;  1POP A;  2HHN A;  3IOQ A;  1AYV A;  3IV2 A;  1X9Y A;  2Y6E A;  1AYU A;  2G8E A;  4PP1 A;  1CV8 A;  5JH3 A;  1GCB A;  3K24 A;  3BOW A;  5CHT A;  4G54 A;  4YYR A;  1M6D A;  2GHU A;  2XU3 A;  2E02 A;  1SNK A;  3KX1 A;  4W4U A;  2DC6 A;  2DC7 A;  3V6C A;  4BS5 A;  2XU4 A;  3N3K A;  2DZY A;  7PCK A;  2AUX A;  2PNS A;  1TU6 A;  4YV8 A;  1TL9 A;  3CH3 X;  2WBF X;  1PE6 A;  2F7D A;  2FRQ A;  2DJG B;  2NQG A;  1ZCM A;  4QRX A;  3MHH A;  1CB5 A;  1EWO A;  4DMY A;  2NQA A;  3QJ3 A;  3C9E A;  2FYE A;  4P6G A;  3RVX A;  3CBK A;  4YYV A;  1HUC B;  1EWM A;  1MDW A;  1PXV A;  5A24 A;  1CJL A;  3U8E A;  1A6R A;  3IMA A;  1AEC A;  2C0Y A;  1U9V A;  1NQC A;  1EWP A;  1KHP A;  4YVA A;  4PAD A;  3E1Z B;  4X6J A;  3K9M A;  1F2C A;  1STF E;  2BDL A;  1BP4 A;  5CVM A;  1MIR A;  2AS8 A;  3QSD A;  4X6I A;  1ME4 A;  3I06 A;  1GEC E;  2HH5 A;  1PAD A;  1Y4H A;  1DEU A;  2VHS A;  3RVV A;  2B1N A;  2G6D A;  2XU1 A;  2YJC A;  3KKU A;  5K16 A;  4W5C A;  1AU0 A;  2AVW A;  2BDZ A;  3DF0 A;  3H6S A;  4CDF B;  1MEG A;  3PBH A;  3BWK A;  4QRG A;  4FJC A;  1NLJ A;  4ZUX U;  2R6N A;  4YYW A;  2OUL A;  2E00 A;  4QBB A;  2PAD A;  1BY8 A;  4YYS A;  2DCB A;  3MHS A;  2DZZ A;  1QDQ A;  3KSE A;  3P5X A;  2IBI A;  1YAL A;  1CS8 A;  1PBH A;  3AI8 A;  3KW9 A;  2IPP B;  1AYW A;  4MZO A;  1CQD A;  2AYO A;  2PRE A;  1EWL A;  2YJ9 A;  1YVB A;  1YT7 A;  3P5V A;  3LXS A;  1Q6K A;  4I07 A;  1K3B B;  4BSQ A;  4QRV A;  5PAD A;  3M99 A;  1PPD A;  2DC9 A;  1O0E A;  1YK7 A;  2NQI A;  1CTE A;  2PBH A;  1S4V A;  3TNX A;  4AXL A;  2FQ9 A;  1QXP A;  3D6S A;  3GCB A;  1KXR A;  1ICF A;  1PPP A;  1AU4 A;  3H8C A;  3PNR A;  3BPF A;  1AIM A;  3N3G A;  1QOL A;  2B1M A;  4KLB A;  2HXZ A;  2R9O A;  3NHE A;  1MEM A;  4OEM A;  3O1G A;  1KFX L;  4CDC B;  1KHQ A;  2R9M A;  3WXG A;  1MHW A;  4Q8H A;  2FUD A;  2CIO A;  3BCN A;  2AYN A;  5EF4 A;  3CH2 X;  1MS6 A;  1AU2 A;  2AIM A;  4YYU A;  4Q8G A;  2DJF B;  5CVN B;  6PAD A;  4XUI A;  4MSX A;  4WA6 A;  3IHP A;  1THE A;  3PW3 A;  1PCI A;  3S3R A;  4K7C A;  3BPM A;  5CVO B;  4AXM A;  3S3Q A;  1F29 A;  3HHI A;  4BS6 A;  4W5B A;  2Y5B A; 
#chains in the Genus database with same CATH topology
 2YJB A;  1JQP A;  1FH0 A;  3KFQ A;  3MTN A;  5KO3 A;  3P5U A;  2H7J A;  5JA7 A;  1F2B A;  2P7U A;  9PAP A;  1U9X A;  3WXF A;  1SP4 B;  5CHV A;  3F75 A;  1NB3 A;  3IUT A;  3MP2 A;  2OZ2 A;  3KWZ A;  4I04 A;  4RF0 A;  1DF0 A;  4PT5 A;  3H7D A;  2R9C A;  3KWB X;  4MM3 B;  1EF7 A;  1ME3 A;  1NPZ A;  3QT4 A;  4OVZ A;  1UKF A;  1TLO A;  3BBA A;  1KFU L;  2OP3 A;  4CDD B;  3HHA A;  4N4Z A;  1Y08 A;  2DCD A;  2ARY A;  2GFO A;  3K8U A;  3H89 A;  4CZW A;  4RKX A;  1CSB B;  3OF9 A;  3B79 A;  5EGW A;  3C0R A;  4QH6 A;  1U9Q X;  1GMY A;  3RVW A;  5JZE A;  2G7Y A;  1ZIV A;  2NQD B;  1PPO A;  4OEL A;  2CB5 A;  3OF8 A;  2AUZ A;  3MOR A;  2P0R A;  1CPJ A;  1DKI A;  3I3T A;  1AU3 A;  2JRI A;  3WXE A;  2JQG R;  1PIP A;  3BC3 A;  4P16 A;  4XR7 A;  1VSN A;  2E03 A;  2P86 A;  4HWY A;  1XKG A;  1U5I A;  2BTW A;  4A5U A;  4FIP A;  2FT2 A;  3V6E A;  2HD5 A;  2DCA A;  2O6X A;  4PI3 A;  5J94 A;  3USV A;  1NB5 A;  3OIS A;  8PCH A;  2J7Q C;  4BQV A;  4N8W A;  2R9F A;  1ITO A;  2XU5 A;  5F02 A;  1QMY A;  2AGA A;  4RY2 A;  2FO5 A;  3P5W A;  2AU1 A;  2R9N A;  3O0U A;  3LFY A;  1F2A A;  4BPV A;  1U9W A;  3N4C A;  4DMX A;  1YK8 A;  1PPN A;  1BGO A;  2F1G A;  3HD3 A;  2DCC A;  3ERV A;  3H8B A;  2E01 A;  2FTD A;  3BY4 A;  2DC8 A;  2ACT A;  4X6H A;  3ZUA A;  1VJV A;  1CVZ A;  4YYQ A;  3IEJ A;  4MZS A;  3F5V A;  4CDE B;  2JQF R;  4N79 A;  2BU3 A;  3OVX A;  4P6E A;  5EZQ A;  2ATO A;  2FRA A;  1IWD A;  4I05 A;  1ATK A;  1NL6 A;  3PDF A;  4M0W A;  2VHF A;  1GLO A;  2G8J A;  3HWN A;  1BQI A;  2YJ2 A;  4FK5 A;  3W31 A;  3PRM A;  2YJ8 A;  5FPW A;  3IFU A;  4REZ A;  4BOU A;  4PP2 E;  1PVJ A;  3CBJ A;  3OVZ A;  1POP A;  2HHN A;  3IOQ A;  1AYV A;  3IV2 A;  1X9Y A;  2Y6E A;  1AYU A;  2G8E A;  5E6J A;  4PP1 A;  1CV8 A;  5JH3 A;  2Z84 A;  1GCB A;  3K24 A;  3BOW A;  4XZX A;  5CHT A;  4G54 A;  4YYR A;  1M6D A;  2GHU A;  2J7Q A;  2XU3 A;  2E02 A;  1SNK A;  3KX1 A;  4W4U A;  2DC6 A;  2DC7 A;  3V6C A;  4BS5 A;  2XU4 A;  3N3K A;  2DZY A;  3RNV A;  7PCK A;  2AUX A;  2PNS A;  1TU6 A;  4YV8 A;  1TL9 A;  3CH3 X;  2WBF X;  3B21 A;  1PE6 A;  3E9S A;  2F7D A;  2FRQ A;  2DJG B;  2NQG A;  1ZCM A;  4QRX A;  3MHH A;  1CB5 A;  1EWO A;  4DMY A;  2NQA A;  3QJ3 A;  3C9E A;  2FYE A;  4P6G A;  3RVX A;  3CBK A;  4YYV A;  1HUC B;  1EWM A;  1MDW A;  1PXV A;  5A24 A;  1CJL A;  3PT2 A;  3U8E A;  1A6R A;  3IMA A;  1AEC A;  2C0Y A;  3PHW A;  1U9V A;  4IP3 A;  4D8I A;  4ZTB A;  1NQC A;  3PHX A;  1EWP A;  4BOZ A;  1KHP A;  4YVA A;  3TMP A;  3W30 A;  4PAD A;  3E1Z B;  4X6J A;  3K9M A;  1F2C A;  1STF E;  2FE8 A;  2BDL A;  1BP4 A;  5CVM A;  1MIR A;  3O65 A;  2AS8 A;  3QSD A;  4X6I A;  1ME4 A;  3I06 A;  1GEC E;  2HH5 A;  1PAD A;  1Y4H A;  4OW0 A;  1DEU A;  2VHS A;  3RVV A;  2B1N A;  2G6D A;  2DOS A;  2XU1 A;  3MTV A;  2YJC A;  3KKU A;  5K16 A;  4W5C A;  1AU0 A;  2AVW A;  2BDZ A;  3DF0 A;  3H6S A;  4CDF B;  4BOP A;  1MEG A;  4BOS A;  1YZB A;  3PBH A;  3BWK A;  4QRG A;  4FJC A;  1NLJ A;  4ZUX U;  2R6N A;  4YYW A;  2OUL A;  2E00 A;  4QBB A;  2PAD A;  1BY8 A;  4YYS A;  2DCB A;  3MHS A;  2DZZ A;  4HXD B;  1QDQ A;  4D8E A;  3KSE A;  3P5X A;  2IBI A;  1YAL A;  1CS8 A;  1PBH A;  3AI8 A;  3KW9 A;  2IPP B;  1AYW A;  4D8B A;  3PSE A;  4MZO A;  1CQD A;  2AYO A;  2PRE A;  1EWL A;  2YJ9 A;  1YVB A;  4MI7 A;  1YT7 A;  3P5V A;  3LXS A;  1Q6K A;  4I07 A;  1K3B B;  4BSQ A;  4OVZ B;  4QRV A;  5PAD A;  3M99 A;  1PPD A;  2DC9 A;  1O0E A;  1YK7 A;  2NQI A;  1CTE A;  2PBH A;  1S4V A;  3TNX A;  3PRP A;  4AXL A;  2FQ9 A;  2HWK A;  1QXP A;  3D6S A;  3BB7 A;  3GCB A;  5EZS A;  1KXR A;  1ICF A;  1PPP A;  1AU4 A;  3H8C A;  3PNR A;  3BPF A;  1AIM A;  4GUA A;  3N3G A;  3ZNH A;  1QOL A;  2JTC A;  2B1M A;  4KLB A;  4BOQ A;  3OQC A;  2HXZ A;  2R9O A;  3NHE A;  1MEM A;  4OEM A;  3O1G A;  1KFX L;  4CDC B;  1KHQ A;  2R9M A;  3PHU A;  3WXG A;  3MJ5 A;  1MHW A;  4Q8H A;  2FUD A;  2CIO A;  4R3D A;  3BCN A;  2AYN A;  5EF4 A;  3CH2 X;  1MS6 A;  2BTW B;  1AU2 A;  2AIM A;  4YYU A;  4Q8G A;  2DJF B;  4IUM A;  5CVN B;  6PAD A;  4RNA A;  4XUI A;  4MSX A;  4WA6 A;  3IHP A;  4RF1 A;  2UZJ A;  1THE A;  3PW3 A;  1PCI A;  3S3R A;  4K7C A;  3BPM A;  5CVO B;  3TRK A;  4WUR A;  4AXM A;  3S3Q A;  1F29 A;  3HHI A;  4BS6 A;  4W5B A;  2Y5B A; 
#chains in the Genus database with same CATH homology
 2YJB A;  1JQP A;  1FH0 A;  3KFQ A;  3MTN A;  3P5U A;  2H7J A;  5JA7 A;  1F2B A;  2P7U A;  1W5R A;  9PAP A;  1U9X A;  3WXF A;  1SP4 B;  5CHV A;  3F75 A;  3LTW A;  1NB3 A;  3IUT A;  2OZ2 A;  3KWZ A;  4I04 A;  1DF0 A;  3H7D A;  2R9C A;  3KWB X;  1EF7 A;  1ME3 A;  1NPZ A;  3QT4 A;  1TLO A;  1KFU L;  2OP3 A;  4CDD B;  3HHA A;  4N4Z A;  1Y08 A;  2DCD A;  2ARY A;  2GFO A;  3K8U A;  3H89 A;  4CZW A;  1CSB B;  3OF9 A;  3B79 A;  5EGW A;  4QH6 A;  1U9Q X;  1GMY A;  3RVW A;  2G7Y A;  1ZIV A;  2NQD B;  1PPO A;  4OEL A;  2CB5 A;  3OF8 A;  2AUZ A;  3MOR A;  2P0R A;  1CPJ A;  2BSZ A;  3I3T A;  1AU3 A;  3WXE A;  2JQG R;  1PIP A;  3BC3 A;  4XR7 A;  1VSN A;  2E03 A;  2P86 A;  4HWY A;  1XKG A;  1U5I A;  4FIP A;  2FT2 A;  3V6E A;  2HD5 A;  2DCA A;  2O6X A;  4PI3 A;  5J94 A;  3USV A;  1NB5 A;  3OIS A;  8PCH A;  4BQV A;  4N8W A;  2R9F A;  1ITO A;  2XU5 A;  1W6F A;  5F02 A;  1QMY A;  4RY2 A;  2FO5 A;  3P5W A;  2AU1 A;  2R9N A;  3O0U A;  3LFY A;  1F2A A;  4BPV A;  1U9W A;  3N4C A;  4DMX A;  1YK8 A;  1PPN A;  1BGO A;  2F1G A;  3HD3 A;  2DCC A;  3ERV A;  3H8B A;  2E01 A;  2FTD A;  2DC8 A;  2ACT A;  4X6H A;  3ZUA A;  1VJV A;  1CVZ A;  4YYQ A;  4C5P A;  3IEJ A;  4MZS A;  3F5V A;  4CDE B;  4NV8 A;  2JQF R;  4N79 A;  3OVX A;  4P6E A;  2ATO A;  2FRA A;  1IWD A;  4I05 A;  1ATK A;  1NL6 A;  3PDF A;  2VHF A;  1GLO A;  2G8J A;  3HWN A;  1BQI A;  2YJ2 A;  4FK5 A;  2YJ8 A;  5FPW A;  4GUZ A;  4PP2 E;  3CBJ A;  3OVZ A;  1POP A;  2HHN A;  3IOQ A;  1AYV A;  3IV2 A;  1X9Y A;  2Y6E A;  1AYU A;  2G8E A;  4PP1 A;  1CV8 A;  5JH3 A;  1GCB A;  3K24 A;  3BOW A;  5CHT A;  4G54 A;  4YYR A;  1M6D A;  2GHU A;  2XU3 A;  2E02 A;  1W4T A;  1SNK A;  3KX1 A;  4W4U A;  2DC6 A;  2DC7 A;  3V6C A;  4BS5 A;  2XU4 A;  3N3K A;  2DZY A;  7PCK A;  2AUX A;  2PNS A;  1TU6 A;  4YV8 A;  1TL9 A;  3CH3 X;  2WBF X;  1PE6 A;  2F7D A;  2FRQ A;  2DJG B;  2NQG A;  1GX3 A;  1ZCM A;  4QRX A;  3MHH A;  1CB5 A;  1EWO A;  4DMY A;  2NQA A;  3QJ3 A;  3C9E A;  2FYE A;  4P6G A;  3RVX A;  3D9W A;  3CBK A;  4YYV A;  1HUC B;  1EWM A;  1MDW A;  1PXV A;  5A24 A;  1CJL A;  3U8E A;  1A6R A;  3IMA A;  1AEC A;  2C0Y A;  1U9V A;  1NQC A;  1EWP A;  1KHP A;  4YVA A;  2VFB A;  4PAD A;  3E1Z B;  4X6J A;  3K9M A;  4BGF A;  1F2C A;  1STF E;  2BDL A;  1E2T A;  1BP4 A;  5CVM A;  1MIR A;  2AS8 A;  3QSD A;  4X6I A;  1ME4 A;  3I06 A;  1GEC E;  2HH5 A;  1PAD A;  1Y4H A;  1DEU A;  2VHS A;  3RVV A;  2B1N A;  2G6D A;  2XU1 A;  2YJC A;  3KKU A;  5K16 A;  4W5C A;  1AU0 A;  2AVW A;  2BDZ A;  3DF0 A;  3H6S A;  4CDF B;  1MEG A;  3PBH A;  3BWK A;  4QRG A;  4FJC A;  1NLJ A;  2VFC A;  2R6N A;  4ZUX U;  4YYW A;  2OUL A;  2E00 A;  4QBB A;  2PAD A;  1BY8 A;  4YYS A;  2DCB A;  3MHS A;  2DZZ A;  1QDQ A;  3KSE A;  3P5X A;  2IBI A;  1YAL A;  1CS8 A;  1PBH A;  3AI8 A;  3KW9 A;  2IPP B;  1AYW A;  4MZO A;  1CQD A;  2AYO A;  2PRE A;  1EWL A;  2YJ9 A;  1YVB A;  4NV7 A;  1YT7 A;  3P5V A;  3LXS A;  1Q6K A;  4I07 A;  1K3B B;  4BSQ A;  4QRV A;  5PAD A;  3M99 A;  1PPD A;  2DC9 A;  1O0E A;  1YK7 A;  2NQI A;  1CTE A;  2PBH A;  1S4V A;  3TNX A;  4AXL A;  2FQ9 A;  1QXP A;  3D6S A;  3GCB A;  1KXR A;  1ICF A;  1PPP A;  1AU4 A;  3H8C A;  3PNR A;  3BPF A;  1AIM A;  3N3G A;  1QOL A;  2B1M A;  4KLB A;  2HXZ A;  2R9O A;  3NHE A;  1MEM A;  4OEM A;  3O1G A;  1KFX L;  4CDC B;  1KHQ A;  2R9M A;  3WXG A;  1MHW A;  4Q8H A;  2FUD A;  2CIO A;  3BCN A;  2AYN A;  5EF4 A;  3CH2 X;  1MS6 A;  1AU2 A;  2AIM A;  4YYU A;  4Q8G A;  2DJF B;  5CVN B;  4B55 A;  6PAD A;  4XUI A;  4MSX A;  4WA6 A;  3IHP A;  1THE A;  3PW3 A;  1PCI A;  3S3R A;  4K7C A;  3BPM A;  5CVO B;  4AXM A;  3S3Q A;  1F29 A;  3HHI A;  4BS6 A;  4W5B A;  2Y5B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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