3IEJA

Pyrazole-based cathepsin s inhibitors with arylalkynes as p1 binding elements
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
221
structure length
221
Chain Sequence
AALPDSVDWREKGCVTEVKYQGSCGASWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEILQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Cathepsin S
total genus 69
structure length 221
sequence length 221
chains with identical sequence B
ec nomenclature ec 3.4.22.27: Cathepsin S.
pdb deposition date 2009-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3iejA00
2G6DA 1CTEA 3RVVA 2R9OA 1GLOA 2YJ9A 3BC3A 1U9VA 4N4ZA 1NB5A 2P0RA 4YYWA 2OP3A 4PI3A 1NL6A 5F02A 2DJFB 2XU1A 4BSQA 4BS6A 1ZIVA 2NQIA 1MIRA 2PBHA 5EGWA 4W5BA 2OZ2A 4DMYA 3C9EA 3BPFA 3F75A 4OEMA 2HXZA 2DC9A 2YJBA 4X6HA 2XU5A 3E1ZB 2HHNA 1VSNA 3PW3A 1BGOA 1Q6KA 3H8CA 4XUIA 2AS8A 3OVZA 4CZWA 3CH2X 1MEMA 2PADA 3OISA 2YJ8A 2FTDA 1YALA 1MEGA 2AYNA 1EWPA 2DC6A 1KFUL 1QOLA 3NHEA 5K16A 3AI8A 9PAPA 4MZSA 3N3GA 2NQDB 3OF9A 4MSXA 2DCBA 4W4UA 1U9XA 2O6XA 3V6CA 4YYVA 2FYEA 2OULA 2DZZA 2XU3A 3K9MA 2VHSA 3DF0A 1CS8A 4W5CA 3I06A 1NPZA 1THEA 1VJVA 4BPVA 1PPNA 4KLBA 1POPA 1JQPA 2FUDA 4FJCA 2FO5A 3HD3A 5JH3A 2B1MA 1HUCB 4YV8A 1CV8A 3MORA 1A6RA 2DZYA 5A24A 2R9MA 4ZUXU 1MS6A 7PCKA 5PADA 3CH3X 3BOWA 4QBBA 4RY2A 2Y6EA 1TU6A 1GECE 1MHWA 3GCBA 1SP4B 2FRAA 4QH6A 1U9WA 3P5XA 2DC8A 1MDWA 3IUTA 2G7YA 2R9FA 3USVA 8PCHA 4XR7A 5J94A 1SNKA 3MTNA 3KSEA 2H7JA 2E03A 3RVWA 3H7DA 6PADA 4DMXA 5FPWA 4CDCB 2XU4A 2PREA 4PP2E 1PE6A 1NLJA 1NQCA 4N8WA 1Y4HA 1U5IA 2IPPB 4I04A 4FIPA 1GMYA 1QDQA 2FQ9A 3KFQA 1F2CA 2FT2A 3F5VA 4CDDB 3K8UA 2R6NA 3P5WA 1YK7A 1PCIA 2HH5A 2DCCA 3KKUA 3WXEA 1U9QX 2AU1A 3N4CA 1CJLA 1ZCMA 3MHSA 2G8JA 3BWKA 1NB3A 1BQIA 3H8BA 1QXPA 3I3TA 3HHIA 3CBKA 4YYRA 1Y08A 4X6JA 2E01A 4X6IA 4Q8GA 3P5VA 2DJGB 1BY8A 5CVMA 4YVAA 4YYSA 3KX1A 5EF4A 1AU2A 4BQVA 2CIOA 4AXMA 1F29A 2F1GA 1CSBB 3ZUAA 1QMYA 2HD5A 2PNSA 3PDFA 3P5UA 3U8EA 1AU0A 4AXLA 1EWOA 3H6SA 5CVOB 2NQAA 3O0UA 1AYVA 3S3RA 2CB5A 2DC7A 3HHAA 3S3QA 3H89A 3OVXA 3KW9A 1ATKA 1CPJA 2F7DA 4WA6A 3D6SA 2E00A 3RVXA 1BP4A 1YK8A 3MHHA 1TLOA 3V6EA 1KHPA 1IWDA 2ARYA 3HWNA 2VHFA 5CHTA 3B79A 5CHVA 3IEJA 4P6EA 1EWLA 2ATOA 3LFYA 1TL9A 1PBHA 2G8EA 1EWMA 2C0YA 2R9CA 3PBHA 2DCAA 1ITOA 1F2AA 1GCBA 3IHPA 2JQFR 1F2BA 1KHQA 4P6GA 1CVZA 4FK5A 1AU4A 1PIPA 1YT7A 2R9NA 2AYOA 4I07A 3IMAA 2NQGA 3OF8A 4YYQA 3BPMA 4QRVA 1O0EA 4QRXA 3QJ3A 3TNXA 1PPDA 3QT4A 2GFOA 2P86A 1ICFA 2YJCA 3IV2A 1AU3A 4G54A 1YVBA 2AUZA 3QSDA 2AUXA 3CBJA 2Y5BA 2DCDA 1KXRA 3O1GA 1AYWA 2IBIA 2YJ2A 3ERVA 4BS5A 1KFXL 1AYUA 1S4VA 3KWBX 4YYUA 1FH0A 4OELA 3LXSA 1K3BB 3KWZA 2WBFX 3BCNA 4HWYA 1PPOA 5JA7A 4K7CA 4CDEB 1PADA 1DF0A 2GHUA 2P7UA 2B1NA 4PADA 2AIMA 1STFE 1EF7A 1M6DA 4CDFB 4QRGA 1ME3A 1CQDA 3N3KA 1DEUA 4I05A 2FRQA 1CB5A 2BDLA 1ME4A 3PNRA 5CVNB 3WXFA 1AECA 1XKGA 4N79A 2E02A 3IOQA 1PXVA 1X9YA 3K24A 2BDZA 2AVWA 4Q8HA 2JQGR 2ACTA 4PP1A 1AIMA 3WXGA 3M99A 4MZOA 1PPPA
chains in the Genus database with same CATH superfamily
3RNVA 3TRKA 2G6DA 1CTEA 3RVVA 2R9OA 1GLOA 2YJ9A 3BC3A 1U9VA 4N4ZA 1NB5A 2P0RA 4YYWA 2OP3A 4PI3A 1NL6A 5F02A 2DJFB 2XU1A 4BSQA 4BS6A 1ZIVA 2NQIA 1MIRA 2PBHA 5EGWA 4W5BA 2OZ2A 4DMYA 3C9EA 3BPFA 3F75A 4IUMA 4OEMA 1UKFA 2HXZA 2DC9A 2YJBA 4REZA 4X6HA 2XU5A 3E1ZB 2HHNA 1VSNA 3PW3A 1BGOA 1Q6KA 4R3DA 3H8CA 4XUIA 2AS8A 3OVZA 4CZWA 4RKXA 3CH2X 1MEMA 2PADA 3OISA 2YJ8A 2FTDA 1YALA 1MEGA 2AYNA 1EWPA 2DC6A 1KFUL 1QOLA 2JTCA 3MJ5A 3W31A 3NHEA 5K16A 3AI8A 4BOPA 9PAPA 4MZSA 3N3GA 2NQDB 3OF9A 4MSXA 2DCBA 4W4UA 1U9XA 2O6XA 3V6CA 4YYVA 2FYEA 4BOSA 2OULA 2DZZA 2XU3A 3K9MA 2VHSA 3DF0A 1CS8A 4W5CA 3I06A 1NPZA 1THEA 1VJVA 4BPVA 1PPNA 4KLBA 1POPA 3PHXA 1JQPA 2FUDA 4FJCA 2FO5A 3HD3A 5JH3A 2B1MA 1HUCB 4YV8A 4XZXA 1CV8A 3MORA 1A6RA 2DZYA 5A24A 2R9MA 4ZUXU 1MS6A 7PCKA 5PADA 3CH3X 1DKIA 3BOWA 4QBBA 2BU3A 4RY2A 2Y6EA 1TU6A 1GECE 1MHWA 3GCBA 1SP4B 2FRAA 3PHUA 4QH6A 1U9WA 3P5XA 2DC8A 1MDWA 3MTVA 3IUTA 2G7YA 2R9FA 3USVA 8PCHA 4XR7A 5J94A 1SNKA 3MTNA 3C0RA 4HXDB 3KSEA 2H7JA 2E03A 3RVWA 3BY4A 3H7DA 5E6JA 6PADA 4DMXA 5FPWA 4CDCB 2XU4A 2PREA 3O65A 3PT2A 4PP2E 1PE6A 1NLJA 1NQCA 4N8WA 1Y4HA 1U5IA 2IPPB 4I04A 2Z84A 4FIPA 1GMYA 1QDQA 2FQ9A 3KFQA 1F2CA 2FT2A 3F5VA 4CDDB 3K8UA 2R6NA 3P5WA 1YK7A 1PCIA 2HH5A 2DCCA 3KKUA 3WXEA 1U9QX 2AU1A 3N4CA 1CJLA 1ZCMA 3MHSA 2G8JA 3BWKA 1NB3A 1BQIA 3H8BA 4D8EA 4BOUA 1QXPA 3I3TA 3HHIA 2AGAA 3CBKA 4YYRA 1Y08A 4X6JA 2E01A 4X6IA 4Q8GA 3P5VA 2J7QA 2DJGB 1BY8A 5CVMA 4A5UA 4YVAA 4YYSA 3KX1A 5EF4A 1AU2A 4BQVA 2CIOA 4AXMA 1F29A 4D8IA 4PT5A 2F1GA 1CSBB 3ZNHA 4D8BA 3ZUAA 1QMYA 1PVJA 2HD5A 2PNSA 3PDFA 3P5UA 3U8EA 1AU0A 4AXLA 1EWOA 3H6SA 5CVOB 2NQAA 2DOSA 3O0UA 1AYVA 3S3RA 2CB5A 2DC7A 3HHAA 3S3QA 3H89A 3OVXA 3KW9A 1ATKA 1CPJA 2F7DA 4WA6A 3D6SA 2E00A 3RVXA 1BP4A 1YK8A 3MHHA 1TLOA 3V6EA 1KHPA 1IWDA 2ARYA 3HWNA 2VHFA 2J7QC 5CHTA 1YZBA 3B79A 5CHVA 3IEJA 3PSEA 4P6EA 1EWLA 2ATOA 3LFYA 4RF1A 1TL9A 4IP3A 1PBHA 2G8EA 1EWMA 2C0YA 2R9CA 3PBHA 2DCAA 1ITOA 1F2AA 1GCBA 3IHPA 4WURA 2JQFR 1F2BA 1KHQA 4P6GA 1CVZA 4FK5A 1AU4A 1PIPA 1YT7A 5EZSA 2R9NA 4BOQA 4OVZA 4RF0A 2AYOA 4I07A 3IMAA 2NQGA 3OF8A 4YYQA 3BPMA 4QRVA 2BTWA 1O0EA 4QRXA 3QJ3A 3TNXA 1PPDA 3QT4A 2GFOA 2P86A 1ICFA 4ZTBA 2YJCA 3IV2A 1AU3A 4G54A 1YVBA 2AUZA 3QSDA 3MP2A 2AUXA 3CBJA 2Y5BA 3BBAA 2DCDA 4MM3B 1KXRA 5EZQA 3O1GA 3E9SA 1AYWA 2IBIA 2YJ2A 3ERVA 4BS5A 1KFXL 1AYUA 1S4VA 4RNAA 3OQCA 4GUAA 3KWBX 3B21A 4YYUA 4BOZA 1FH0A 4OELA 3LXSA 1K3BB 3KWZA 5JZEA 2WBFX 3BCNA 2UZJA 2FE8A 4HWYA 1PPOA 5JA7A 5KO3A 4K7CA 4CDEB 1PADA 4MI7A 1DF0A 2HWKA 4OVZB 2GHUA 2P7UA 2JRIA 2B1NA 4PADA 2AIMA 1STFE 1EF7A 1M6DA 3TMPA 4CDFB 3BB7A 4QRGA 1ME3A 1CQDA 3N3KA 1DEUA 2BTWB 2FRQA 4I05A 3W30A 1CB5A 2BDLA 1ME4A 4M0WA 3PNRA 5CVNB 3IFUA 3WXFA 1AECA 1XKGA 4N79A 2E02A 3IOQA 4P16A 1PXVA 4OW0A 1X9YA 3K24A 2BDZA 2AVWA 4Q8HA 3PRPA 3PHWA 2JQGR 2ACTA 4PP1A 1AIMA 3WXGA 3M99A 3PRMA 4MZOA 1PPPA
chains in the Genus database with same CATH topology
2G6DA 1CTEA 3RVVA 2R9OA 1GLOA 2YJ9A 3BC3A 1U9VA 3D9WA 4N4ZA 1NB5A 2P0RA 4YYWA 2OP3A 4PI3A 1NL6A 5F02A 2DJFB 2XU1A 4BSQA 4BS6A 1ZIVA 2NQIA 1MIRA 2PBHA 4C5PA 5EGWA 4W5BA 2OZ2A 4DMYA 3C9EA 3BPFA 3F75A 4OEMA 2HXZA 2DC9A 2YJBA 4X6HA 2XU5A 3E1ZB 2HHNA 1VSNA 3LTWA 3PW3A 1BGOA 1Q6KA 1W5RA 3H8CA 4XUIA 2AS8A 3OVZA 1W6FA 4CZWA 3CH2X 1MEMA 2PADA 3OISA 2YJ8A 2FTDA 1YALA 1MEGA 2AYNA 1EWPA 2DC6A 1KFUL 1QOLA 3NHEA 5K16A 3AI8A 1W4TA 9PAPA 4MZSA 3N3GA 2NQDB 3OF9A 4MSXA 2DCBA 4W4UA 1U9XA 2O6XA 3V6CA 4YYVA 2FYEA 2OULA 2DZZA 2XU3A 3K9MA 2VHSA 3DF0A 1CS8A 4W5CA 3I06A 1NPZA 1THEA 1VJVA 4BPVA 1PPNA 4KLBA 1POPA 1JQPA 2FUDA 4FJCA 2FO5A 3HD3A 5JH3A 2B1MA 1HUCB 4YV8A 1CV8A 3MORA 1A6RA 2DZYA 5A24A 2R9MA 4ZUXU 1MS6A 7PCKA 5PADA 3CH3X 3BOWA 4QBBA 4RY2A 2Y6EA 1TU6A 1GECE 1MHWA 3GCBA 1SP4B 2FRAA 4QH6A 1U9WA 3P5XA 2DC8A 1MDWA 3IUTA 2G7YA 2R9FA 3USVA 8PCHA 4XR7A 5J94A 1SNKA 3MTNA 3KSEA 2H7JA 2E03A 3RVWA 3H7DA 6PADA 4DMXA 5FPWA 4NV8A 4CDCB 2XU4A 2PREA 4PP2E 1PE6A 1NLJA 1NQCA 4N8WA 1Y4HA 1U5IA 2IPPB 4I04A 4FIPA 1GMYA 2VFBA 1QDQA 2FQ9A 3KFQA 4B55A 1F2CA 2FT2A 3F5VA 4CDDB 3K8UA 2R6NA 3P5WA 1YK7A 1PCIA 2HH5A 2DCCA 3KKUA 3WXEA 1U9QX 2AU1A 3N4CA 1CJLA 1ZCMA 3MHSA 2G8JA 3BWKA 1NB3A 1BQIA 3H8BA 1QXPA 3I3TA 3HHIA 3CBKA 4YYRA 1Y08A 4X6JA 2E01A 4X6IA 4Q8GA 1GX3A 3P5VA 2DJGB 1BY8A 5CVMA 4YVAA 4YYSA 3KX1A 2BSZA 5EF4A 1AU2A 4BQVA 4BGFA 2CIOA 4AXMA 1F29A 2F1GA 1CSBB 3ZUAA 1QMYA 2HD5A 2PNSA 3PDFA 3P5UA 3U8EA 1AU0A 4AXLA 1EWOA 3H6SA 5CVOB 2NQAA 3O0UA 1AYVA 3S3RA 2CB5A 2DC7A 3HHAA 3S3QA 3H89A 3OVXA 3KW9A 1ATKA 1CPJA 2F7DA 4WA6A 3D6SA 2E00A 3RVXA 1BP4A 1YK8A 3MHHA 1TLOA 3V6EA 1KHPA 1IWDA 2ARYA 3HWNA 2VHFA 5CHTA 3B79A 5CHVA 3IEJA 4P6EA 1EWLA 2ATOA 3LFYA 1E2TA 1TL9A 1PBHA 2G8EA 1EWMA 2C0YA 2R9CA 3PBHA 2DCAA 1ITOA 1F2AA 1GCBA 3IHPA 2JQFR 1F2BA 1KHQA 4P6GA 1CVZA 4FK5A 1AU4A 1PIPA 1YT7A 2R9NA 2AYOA 4I07A 3IMAA 2NQGA 3OF8A 4YYQA 3BPMA 4QRVA 1O0EA 4QRXA 3QJ3A 3TNXA 1PPDA 3QT4A 2GFOA 2P86A 1ICFA 2YJCA 3IV2A 1AU3A 4G54A 1YVBA 2AUZA 3QSDA 2AUXA 3CBJA 2Y5BA 2DCDA 1KXRA 3O1GA 1AYWA 2IBIA 2YJ2A 3ERVA 4BS5A 1KFXL 1AYUA 1S4VA 3KWBX 4YYUA 1FH0A 4OELA 2VFCA 3LXSA 1K3BB 3KWZA 2WBFX 3BCNA 4HWYA 1PPOA 5JA7A 4K7CA 4CDEB 1PADA 1DF0A 2GHUA 2P7UA 2B1NA 4PADA 2AIMA 1STFE 1EF7A 1M6DA 4CDFB 4QRGA 1ME3A 1CQDA 3N3KA 1DEUA 4I05A 2FRQA 1CB5A 2BDLA 4GUZA 1ME4A 3PNRA 5CVNB 3WXFA 1AECA 1XKGA 4N79A 2E02A 3IOQA 4NV7A 1PXVA 1X9YA 3K24A 2BDZA 2AVWA 4Q8HA 2JQGR 2ACTA 4PP1A 1AIMA 3WXGA 3M99A 4MZOA 1PPPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2G6D A;  1CTE A;  3RVV A;  2R9O A;  1GLO A;  2YJ9 A;  3BC3 A;  1U9V A;  4N4Z A;  1NB5 A;  2P0R A;  4YYW A;  2OP3 A;  4PI3 A;  1NL6 A;  5F02 A;  2DJF B;  2XU1 A;  4BSQ A;  4BS6 A;  1ZIV A;  2NQI A;  1MIR A;  2PBH A;  5EGW A;  4W5B A;  2OZ2 A;  4DMY A;  3C9E A;  3BPF A;  3F75 A;  4OEM A;  2HXZ A;  2DC9 A;  2YJB A;  4X6H A;  2XU5 A;  3E1Z B;  2HHN A;  1VSN A;  3PW3 A;  1BGO A;  1Q6K A;  3H8C A;  4XUI A;  2AS8 A;  3OVZ A;  4CZW A;  3CH2 X;  1MEM A;  2PAD A;  3OIS A;  2YJ8 A;  2FTD A;  1YAL A;  1MEG A;  2AYN A;  1EWP A;  2DC6 A;  1KFU L;  1QOL A;  3NHE A;  5K16 A;  3AI8 A;  9PAP A;  4MZS A;  3N3G A;  2NQD B;  3OF9 A;  4MSX A;  2DCB A;  4W4U A;  1U9X A;  2O6X A;  3V6C A;  4YYV A;  2FYE A;  2OUL A;  2DZZ A;  2XU3 A;  3K9M A;  2VHS A;  3DF0 A;  1CS8 A;  4W5C A;  3I06 A;  1NPZ A;  1THE A;  1VJV A;  4BPV A;  1PPN A;  4KLB A;  1POP A;  1JQP A;  2FUD A;  4FJC A;  2FO5 A;  3HD3 A;  5JH3 A;  2B1M A;  1HUC B;  4YV8 A;  1CV8 A;  3MOR A;  1A6R A;  2DZY A;  5A24 A;  2R9M A;  4ZUX U;  1MS6 A;  7PCK A;  5PAD A;  3CH3 X;  3BOW A;  4QBB A;  4RY2 A;  2Y6E A;  1TU6 A;  1GEC E;  1MHW A;  3GCB A;  1SP4 B;  2FRA A;  4QH6 A;  1U9W A;  3P5X A;  2DC8 A;  1MDW A;  3IUT A;  2G7Y A;  2R9F A;  3USV A;  8PCH A;  4XR7 A;  5J94 A;  1SNK A;  3MTN A;  3KSE A;  2H7J A;  2E03 A;  3RVW A;  3H7D A;  6PAD A;  4DMX A;  5FPW A;  4CDC B;  2XU4 A;  2PRE A;  4PP2 E;  1PE6 A;  1NLJ A;  1NQC A;  4N8W A;  1Y4H A;  1U5I A;  2IPP B;  4I04 A;  4FIP A;  1GMY A;  1QDQ A;  2FQ9 A;  3KFQ A;  1F2C A;  2FT2 A;  3F5V A;  4CDD B;  3K8U A;  2R6N A;  3P5W A;  1YK7 A;  1PCI A;  2HH5 A;  2DCC A;  3KKU A;  3WXE A;  1U9Q X;  2AU1 A;  3N4C A;  1CJL A;  1ZCM A;  3MHS A;  2G8J A;  3BWK A;  1NB3 A;  1BQI A;  3H8B A;  1QXP A;  3I3T A;  3HHI A;  3CBK A;  4YYR A;  1Y08 A;  4X6J A;  2E01 A;  4X6I A;  4Q8G A;  3P5V A;  2DJG B;  1BY8 A;  5CVM A;  4YVA A;  4YYS A;  3KX1 A;  5EF4 A;  1AU2 A;  4BQV A;  2CIO A;  4AXM A;  1F29 A;  2F1G A;  1CSB B;  3ZUA A;  1QMY A;  2HD5 A;  2PNS A;  3PDF A;  3P5U A;  3U8E A;  1AU0 A;  4AXL A;  1EWO A;  3H6S A;  5CVO B;  2NQA A;  3O0U A;  1AYV A;  3S3R A;  2CB5 A;  2DC7 A;  3HHA A;  3S3Q A;  3H89 A;  3OVX A;  3KW9 A;  1ATK A;  1CPJ A;  2F7D A;  4WA6 A;  3D6S A;  2E00 A;  3RVX A;  1BP4 A;  1YK8 A;  3MHH A;  1TLO A;  3V6E A;  1KHP A;  1IWD A;  2ARY A;  3HWN A;  2VHF A;  5CHT A;  3B79 A;  5CHV A;  3IEJ A;  4P6E A;  1EWL A;  2ATO A;  3LFY A;  1TL9 A;  1PBH A;  2G8E A;  1EWM A;  2C0Y A;  2R9C A;  3PBH A;  2DCA A;  1ITO A;  1F2A A;  1GCB A;  3IHP A;  2JQF R;  1F2B A;  1KHQ A;  4P6G A;  1CVZ A;  4FK5 A;  1AU4 A;  1PIP A;  1YT7 A;  2R9N A;  2AYO A;  4I07 A;  3IMA A;  2NQG A;  3OF8 A;  4YYQ A;  3BPM A;  4QRV A;  1O0E A;  4QRX A;  3QJ3 A;  3TNX A;  1PPD A;  3QT4 A;  2GFO A;  2P86 A;  1ICF A;  2YJC A;  3IV2 A;  1AU3 A;  4G54 A;  1YVB A;  2AUZ A;  3QSD A;  2AUX A;  3CBJ A;  2Y5B A;  2DCD A;  1KXR A;  3O1G A;  1AYW A;  2IBI A;  2YJ2 A;  3ERV A;  4BS5 A;  1KFX L;  1AYU A;  1S4V A;  3KWB X;  4YYU A;  1FH0 A;  4OEL A;  3LXS A;  1K3B B;  3KWZ A;  2WBF X;  3BCN A;  4HWY A;  1PPO A;  5JA7 A;  4K7C A;  4CDE B;  1PAD A;  1DF0 A;  2GHU A;  2P7U A;  2B1N A;  4PAD A;  2AIM A;  1STF E;  1EF7 A;  1M6D A;  4CDF B;  4QRG A;  1ME3 A;  1CQD A;  3N3K A;  1DEU A;  4I05 A;  2FRQ A;  1CB5 A;  2BDL A;  1ME4 A;  3PNR A;  5CVN B;  3WXF A;  1AEC A;  1XKG A;  4N79 A;  2E02 A;  3IOQ A;  1PXV A;  1X9Y A;  3K24 A;  2BDZ A;  2AVW A;  4Q8H A;  2JQG R;  2ACT A;  4PP1 A;  1AIM A;  3WXG A;  3M99 A;  4MZO A;  1PPP A; 
#chains in the Genus database with same CATH topology
 3RNV A;  3TRK A;  2G6D A;  1CTE A;  3RVV A;  2R9O A;  1GLO A;  2YJ9 A;  3BC3 A;  1U9V A;  4N4Z A;  1NB5 A;  2P0R A;  4YYW A;  2OP3 A;  4PI3 A;  1NL6 A;  5F02 A;  2DJF B;  2XU1 A;  4BSQ A;  4BS6 A;  1ZIV A;  2NQI A;  1MIR A;  2PBH A;  5EGW A;  4W5B A;  2OZ2 A;  4DMY A;  3C9E A;  3BPF A;  3F75 A;  4IUM A;  4OEM A;  1UKF A;  2HXZ A;  2DC9 A;  2YJB A;  4REZ A;  4X6H A;  2XU5 A;  3E1Z B;  2HHN A;  1VSN A;  3PW3 A;  1BGO A;  1Q6K A;  4R3D A;  3H8C A;  4XUI A;  2AS8 A;  3OVZ A;  4CZW A;  4RKX A;  3CH2 X;  1MEM A;  2PAD A;  3OIS A;  2YJ8 A;  2FTD A;  1YAL A;  1MEG A;  2AYN A;  1EWP A;  2DC6 A;  1KFU L;  1QOL A;  2JTC A;  3MJ5 A;  3W31 A;  3NHE A;  5K16 A;  3AI8 A;  4BOP A;  9PAP A;  4MZS A;  3N3G A;  2NQD B;  3OF9 A;  4MSX A;  2DCB A;  4W4U A;  1U9X A;  2O6X A;  3V6C A;  4YYV A;  2FYE A;  4BOS A;  2OUL A;  2DZZ A;  2XU3 A;  3K9M A;  2VHS A;  3DF0 A;  1CS8 A;  4W5C A;  3I06 A;  1NPZ A;  1THE A;  1VJV A;  4BPV A;  1PPN A;  4KLB A;  1POP A;  3PHX A;  1JQP A;  2FUD A;  4FJC A;  2FO5 A;  3HD3 A;  5JH3 A;  2B1M A;  1HUC B;  4YV8 A;  4XZX A;  1CV8 A;  3MOR A;  1A6R A;  2DZY A;  5A24 A;  2R9M A;  4ZUX U;  1MS6 A;  7PCK A;  5PAD A;  3CH3 X;  1DKI A;  3BOW A;  4QBB A;  2BU3 A;  4RY2 A;  2Y6E A;  1TU6 A;  1GEC E;  1MHW A;  3GCB A;  1SP4 B;  2FRA A;  3PHU A;  4QH6 A;  1U9W A;  3P5X A;  2DC8 A;  1MDW A;  3MTV A;  3IUT A;  2G7Y A;  2R9F A;  3USV A;  8PCH A;  4XR7 A;  5J94 A;  1SNK A;  3MTN A;  3C0R A;  4HXD B;  3KSE A;  2H7J A;  2E03 A;  3RVW A;  3BY4 A;  3H7D A;  5E6J A;  6PAD A;  4DMX A;  5FPW A;  4CDC B;  2XU4 A;  2PRE A;  3O65 A;  3PT2 A;  4PP2 E;  1PE6 A;  1NLJ A;  1NQC A;  4N8W A;  1Y4H A;  1U5I A;  2IPP B;  4I04 A;  2Z84 A;  4FIP A;  1GMY A;  1QDQ A;  2FQ9 A;  3KFQ A;  1F2C A;  2FT2 A;  3F5V A;  4CDD B;  3K8U A;  2R6N A;  3P5W A;  1YK7 A;  1PCI A;  2HH5 A;  2DCC A;  3KKU A;  3WXE A;  1U9Q X;  2AU1 A;  3N4C A;  1CJL A;  1ZCM A;  3MHS A;  2G8J A;  3BWK A;  1NB3 A;  1BQI A;  3H8B A;  4D8E A;  4BOU A;  1QXP A;  3I3T A;  3HHI A;  2AGA A;  3CBK A;  4YYR A;  1Y08 A;  4X6J A;  2E01 A;  4X6I A;  4Q8G A;  3P5V A;  2J7Q A;  2DJG B;  1BY8 A;  5CVM A;  4A5U A;  4YVA A;  4YYS A;  3KX1 A;  5EF4 A;  1AU2 A;  4BQV A;  2CIO A;  4AXM A;  1F29 A;  4D8I A;  4PT5 A;  2F1G A;  1CSB B;  3ZNH A;  4D8B A;  3ZUA A;  1QMY A;  1PVJ A;  2HD5 A;  2PNS A;  3PDF A;  3P5U A;  3U8E A;  1AU0 A;  4AXL A;  1EWO A;  3H6S A;  5CVO B;  2NQA A;  2DOS A;  3O0U A;  1AYV A;  3S3R A;  2CB5 A;  2DC7 A;  3HHA A;  3S3Q A;  3H89 A;  3OVX A;  3KW9 A;  1ATK A;  1CPJ A;  2F7D A;  4WA6 A;  3D6S A;  2E00 A;  3RVX A;  1BP4 A;  1YK8 A;  3MHH A;  1TLO A;  3V6E A;  1KHP A;  1IWD A;  2ARY A;  3HWN A;  2VHF A;  2J7Q C;  5CHT A;  1YZB A;  3B79 A;  5CHV A;  3IEJ A;  3PSE A;  4P6E A;  1EWL A;  2ATO A;  3LFY A;  4RF1 A;  1TL9 A;  4IP3 A;  1PBH A;  2G8E A;  1EWM A;  2C0Y A;  2R9C A;  3PBH A;  2DCA A;  1ITO A;  1F2A A;  1GCB A;  3IHP A;  4WUR A;  2JQF R;  1F2B A;  1KHQ A;  4P6G A;  1CVZ A;  4FK5 A;  1AU4 A;  1PIP A;  1YT7 A;  5EZS A;  2R9N A;  4BOQ A;  4OVZ A;  4RF0 A;  2AYO A;  4I07 A;  3IMA A;  2NQG A;  3OF8 A;  4YYQ A;  3BPM A;  4QRV A;  2BTW A;  1O0E A;  4QRX A;  3QJ3 A;  3TNX A;  1PPD A;  3QT4 A;  2GFO A;  2P86 A;  1ICF A;  4ZTB A;  2YJC A;  3IV2 A;  1AU3 A;  4G54 A;  1YVB A;  2AUZ A;  3QSD A;  3MP2 A;  2AUX A;  3CBJ A;  2Y5B A;  3BBA A;  2DCD A;  4MM3 B;  1KXR A;  5EZQ A;  3O1G A;  3E9S A;  1AYW A;  2IBI A;  2YJ2 A;  3ERV A;  4BS5 A;  1KFX L;  1AYU A;  1S4V A;  4RNA A;  3OQC A;  4GUA A;  3KWB X;  3B21 A;  4YYU A;  4BOZ A;  1FH0 A;  4OEL A;  3LXS A;  1K3B B;  3KWZ A;  5JZE A;  2WBF X;  3BCN A;  2UZJ A;  2FE8 A;  4HWY A;  1PPO A;  5JA7 A;  5KO3 A;  4K7C A;  4CDE B;  1PAD A;  4MI7 A;  1DF0 A;  2HWK A;  4OVZ B;  2GHU A;  2P7U A;  2JRI A;  2B1N A;  4PAD A;  2AIM A;  1STF E;  1EF7 A;  1M6D A;  3TMP A;  4CDF B;  3BB7 A;  4QRG A;  1ME3 A;  1CQD A;  3N3K A;  1DEU A;  2BTW B;  2FRQ A;  4I05 A;  3W30 A;  1CB5 A;  2BDL A;  1ME4 A;  4M0W A;  3PNR A;  5CVN B;  3IFU A;  3WXF A;  1AEC A;  1XKG A;  4N79 A;  2E02 A;  3IOQ A;  4P16 A;  1PXV A;  4OW0 A;  1X9Y A;  3K24 A;  2BDZ A;  2AVW A;  4Q8H A;  3PRP A;  3PHW A;  2JQG R;  2ACT A;  4PP1 A;  1AIM A;  3WXG A;  3M99 A;  3PRM A;  4MZO A;  1PPP A; 
#chains in the Genus database with same CATH homology
 2G6D A;  1CTE A;  3RVV A;  2R9O A;  1GLO A;  2YJ9 A;  3BC3 A;  1U9V A;  3D9W A;  4N4Z A;  1NB5 A;  2P0R A;  4YYW A;  2OP3 A;  4PI3 A;  1NL6 A;  5F02 A;  2DJF B;  2XU1 A;  4BSQ A;  4BS6 A;  1ZIV A;  2NQI A;  1MIR A;  2PBH A;  4C5P A;  5EGW A;  4W5B A;  2OZ2 A;  4DMY A;  3C9E A;  3BPF A;  3F75 A;  4OEM A;  2HXZ A;  2DC9 A;  2YJB A;  4X6H A;  2XU5 A;  3E1Z B;  2HHN A;  1VSN A;  3LTW A;  3PW3 A;  1BGO A;  1Q6K A;  1W5R A;  3H8C A;  4XUI A;  2AS8 A;  3OVZ A;  1W6F A;  4CZW A;  3CH2 X;  1MEM A;  2PAD A;  3OIS A;  2YJ8 A;  2FTD A;  1YAL A;  1MEG A;  2AYN A;  1EWP A;  2DC6 A;  1KFU L;  1QOL A;  3NHE A;  5K16 A;  3AI8 A;  1W4T A;  9PAP A;  4MZS A;  3N3G A;  2NQD B;  3OF9 A;  4MSX A;  2DCB A;  4W4U A;  1U9X A;  2O6X A;  3V6C A;  4YYV A;  2FYE A;  2OUL A;  2DZZ A;  2XU3 A;  3K9M A;  2VHS A;  3DF0 A;  1CS8 A;  4W5C A;  3I06 A;  1NPZ A;  1THE A;  1VJV A;  4BPV A;  1PPN A;  4KLB A;  1POP A;  1JQP A;  2FUD A;  4FJC A;  2FO5 A;  3HD3 A;  5JH3 A;  2B1M A;  1HUC B;  4YV8 A;  1CV8 A;  3MOR A;  1A6R A;  2DZY A;  5A24 A;  2R9M A;  4ZUX U;  1MS6 A;  7PCK A;  5PAD A;  3CH3 X;  3BOW A;  4QBB A;  4RY2 A;  2Y6E A;  1TU6 A;  1GEC E;  1MHW A;  3GCB A;  1SP4 B;  2FRA A;  4QH6 A;  1U9W A;  3P5X A;  2DC8 A;  1MDW A;  3IUT A;  2G7Y A;  2R9F A;  3USV A;  8PCH A;  4XR7 A;  5J94 A;  1SNK A;  3MTN A;  3KSE A;  2H7J A;  2E03 A;  3RVW A;  3H7D A;  6PAD A;  4DMX A;  5FPW A;  4NV8 A;  4CDC B;  2XU4 A;  2PRE A;  4PP2 E;  1PE6 A;  1NLJ A;  1NQC A;  4N8W A;  1Y4H A;  1U5I A;  2IPP B;  4I04 A;  4FIP A;  1GMY A;  2VFB A;  1QDQ A;  2FQ9 A;  3KFQ A;  4B55 A;  1F2C A;  2FT2 A;  3F5V A;  4CDD B;  3K8U A;  2R6N A;  3P5W A;  1YK7 A;  1PCI A;  2HH5 A;  2DCC A;  3KKU A;  3WXE A;  1U9Q X;  2AU1 A;  3N4C A;  1CJL A;  1ZCM A;  3MHS A;  2G8J A;  3BWK A;  1NB3 A;  1BQI A;  3H8B A;  1QXP A;  3I3T A;  3HHI A;  3CBK A;  4YYR A;  1Y08 A;  4X6J A;  2E01 A;  4X6I A;  4Q8G A;  1GX3 A;  3P5V A;  2DJG B;  1BY8 A;  5CVM A;  4YVA A;  4YYS A;  3KX1 A;  2BSZ A;  5EF4 A;  1AU2 A;  4BQV A;  4BGF A;  2CIO A;  4AXM A;  1F29 A;  2F1G A;  1CSB B;  3ZUA A;  1QMY A;  2HD5 A;  2PNS A;  3PDF A;  3P5U A;  3U8E A;  1AU0 A;  4AXL A;  1EWO A;  3H6S A;  5CVO B;  2NQA A;  3O0U A;  1AYV A;  3S3R A;  2CB5 A;  2DC7 A;  3HHA A;  3S3Q A;  3H89 A;  3OVX A;  3KW9 A;  1ATK A;  1CPJ A;  2F7D A;  4WA6 A;  3D6S A;  2E00 A;  3RVX A;  1BP4 A;  1YK8 A;  3MHH A;  1TLO A;  3V6E A;  1KHP A;  1IWD A;  2ARY A;  3HWN A;  2VHF A;  5CHT A;  3B79 A;  5CHV A;  3IEJ A;  4P6E A;  1EWL A;  2ATO A;  3LFY A;  1E2T A;  1TL9 A;  1PBH A;  2G8E A;  1EWM A;  2C0Y A;  2R9C A;  3PBH A;  2DCA A;  1ITO A;  1F2A A;  1GCB A;  3IHP A;  2JQF R;  1F2B A;  1KHQ A;  4P6G A;  1CVZ A;  4FK5 A;  1AU4 A;  1PIP A;  1YT7 A;  2R9N A;  2AYO A;  4I07 A;  3IMA A;  2NQG A;  3OF8 A;  4YYQ A;  3BPM A;  4QRV A;  1O0E A;  4QRX A;  3QJ3 A;  3TNX A;  1PPD A;  3QT4 A;  2GFO A;  2P86 A;  1ICF A;  2YJC A;  3IV2 A;  1AU3 A;  4G54 A;  1YVB A;  2AUZ A;  3QSD A;  2AUX A;  3CBJ A;  2Y5B A;  2DCD A;  1KXR A;  3O1G A;  1AYW A;  2IBI A;  2YJ2 A;  3ERV A;  4BS5 A;  1KFX L;  1AYU A;  1S4V A;  3KWB X;  4YYU A;  1FH0 A;  4OEL A;  2VFC A;  3LXS A;  1K3B B;  3KWZ A;  2WBF X;  3BCN A;  4HWY A;  1PPO A;  5JA7 A;  4K7C A;  4CDE B;  1PAD A;  1DF0 A;  2GHU A;  2P7U A;  2B1N A;  4PAD A;  2AIM A;  1STF E;  1EF7 A;  1M6D A;  4CDF B;  4QRG A;  1ME3 A;  1CQD A;  3N3K A;  1DEU A;  4I05 A;  2FRQ A;  1CB5 A;  2BDL A;  4GUZ A;  1ME4 A;  3PNR A;  5CVN B;  3WXF A;  1AEC A;  1XKG A;  4N79 A;  2E02 A;  3IOQ A;  4NV7 A;  1PXV A;  1X9Y A;  3K24 A;  2BDZ A;  2AVW A;  4Q8H A;  2JQG R;  2ACT A;  4PP1 A;  1AIM A;  3WXG A;  3M99 A;  4MZO A;  1PPP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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