4AXLA

Human cathepsin l apo form with zn
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
220
structure length
220
Chain Sequence
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-Ray Crystal Structure Analysis with Human Cathepsin L
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords CATHEPSIN L1
total genus 68
structure length 220
sequence length 220
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2012-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4axlA00
1A6RA 1GECE 3BCNA 1FH0A 1MIRA 3N3GA 2AU1A 4N79A 2HXZA 2XU1A 2AVWA 1AECA 2G8EA 3D6SA 1AU4A 1ZCMA 2G8JA 1MDWA 4MZOA 1TU6A 2YJ2A 4K7CA 2GHUA 1DEUA 3H6SA 1QDQA 1GMYA 2DZYA 5K16A 3H89A 2XU3A 2GFOA 4X6HA 1Q6KA 1EWMA 1F2BA 3WXGA 1IWDA 2E03A 1GCBA 1PPDA 2R9CA 2BDZA 1DF0A 5JA7A 3C9EA 3CBKA 1U9WA 2WBFX 2FRAA 2G6DA 3WXEA 3IUTA 1KFUL 1VJVA 2DCBA 1X9YA 4AXMA 2XU4A 3H7DA 4CDDB 3OF9A 4CZWA 3CBJA 3IV2A 2FTDA 2P0RA 3P5XA 1AYUA 1PIPA 2DJFB 2JQGR 5A24A 3LXSA 1SP4B 1QOLA 2AIMA 1M6DA 1F29A 4P6EA 2AYOA 1O0EA 3CH3X 2B1NA 7PCKA 4FIPA 3P5VA 4ZUXU 1YALA 1NLJA 4RY2A 1AU3A 3BC3A 2DC9A 4G54A 5J94A 4YYSA 9PAPA 1NB3A 2CIOA 2ATOA 2R9MA 4QRXA 4FK5A 1KHPA 3F5VA 3PBHA 1ME3A 3OVXA 1EWOA 2P86A 1VSNA 2JQFR 4FJCA 4N4ZA 1XKGA 3MORA 3DF0A 1U9VA 4KLBA 4XR7A 3HD3A 4CDEB 2DCAA 1AYWA 1CQDA 1F2AA 3H8BA 3NHEA 2VHSA 3K8UA 3HWNA 3I3TA 1ICFA 2P7UA 1KHQA 4PP2E 3V6CA 1AU0A 3K9MA 3TNXA 3AI8A 2YJBA 2FRQA 4DMXA 1KXRA 1YVBA 2DJGB 4CDCB 4Q8GA 2PBHA 1CS8A 2DCCA 1CB5A 2ACTA 2OZ2A 2Y6EA 2E02A 2FO5A 3KW9A 4YYQA 3S3RA 1EWPA 3ZUAA 3WXFA 3IEJA 3E1ZB 1BY8A 4OELA 2AS8A 1ATKA 2DC7A 4QRVA 4I05A 4CDFB 1AIMA 1TLOA 1CSBB 3PDFA 2AUXA 2YJCA 1QMYA 2FT2A 1JQPA 4YYUA 1PADA 2R9FA 3KX1A 2E01A 1U9XA 1PBHA 3B79A 1S4VA 1THEA 1U5IA 5CVOB 3GCBA 5FPWA 1BP4A 2IPPB 4MZSA 2OP3A 3KWZA 4BS6A 3I06A 1ZIVA 2DZZA 2E00A 4DMYA 2F1GA 1F2CA 3F75A 1STFE 1YK7A 3N3KA 1YT7A 2PNSA 3KFQA 3O1GA 3MTNA 2FUDA 1CJLA 1EWLA 1CTEA 3QSDA 3P5UA 3O0UA 3USVA 1QXPA 1BGOA 3BOWA 4P6GA 2YJ9A 1PPPA 1SNKA 3N4CA 1BQIA 2B1MA 3IOQA 4PP1A 1CPJA 1Y08A 1ME4A 2DC8A 1AU2A 3MHSA 1CVZA 4HWYA 4BPVA 3ERVA 3HHIA 2NQIA 3M99A 3OVZA 1MS6A 5PADA 1AYVA 3RVVA 3S3QA 2Y5BA 2R9NA 3IMAA 2DCDA 4YVAA 4N8WA 1GLOA 3LFYA 4I07A 1TL9A 4BSQA 3BWKA 2O6XA 4QH6A 2OULA 5EF4A 2FYEA 3QJ3A 2XU5A 3RVWA 2G7YA 2VHFA 5F02A 4WA6A 3V6EA 3QT4A 1EF7A 1MHWA 1MEGA 4W4UA 1NL6A 3K24A 3H8CA 1U9QX 2PREA 2ARYA 4QBBA 2HH5A 2YJ8A 5CVMA 8PCHA 1PPOA 4BS5A 2F7DA 3HHAA 2NQGA 3BPMA 2NQDB 1PE6A 4PI3A 2CB5A 2HHNA 2R9OA 2R6NA 3KSEA 1NQCA 4YV8A 3CH2X 1ITOA 2AYNA 4X6JA 3RVXA 4XUIA 1PCIA 5CHVA 5JH3A 3U8EA 6PADA 4YYVA 4YYRA 1NB5A 2PADA 3KWBX 3IHPA 4BQVA 1HUCB 3OISA 2HD5A 1NPZA 5CHTA 3OF8A 4OEMA 3BPFA 2AUZA 2DC6A 3PNRA 2NQAA 4PADA 1PPNA 5CVNB 2H7JA 4Q8HA 4I04A 5EGWA 4W5CA 4AXLA 3PW3A 2IBIA 1Y4HA 4QRGA 3KKUA 4MSXA 1KFXL 1MEMA 3MHHA 1PXVA 4W5BA 2C0YA 2FQ9A 1K3BB 4X6IA 1CV8A 1POPA 1YK8A 2BDLA 3P5WA 4YYWA
chains in the Genus database with same CATH superfamily
1A6RA 1GECE 3BCNA 1FH0A 1MIRA 3N3GA 2AU1A 4N79A 3PHWA 2HXZA 2XU1A 2J7QC 3E9SA 2AVWA 4GUAA 1AECA 2G8EA 4MM3B 3B21A 3D6SA 1AU4A 1ZCMA 2G8JA 1MDWA 4MZOA 1TU6A 2YJ2A 4K7CA 2GHUA 3W31A 1DEUA 3H6SA 1QDQA 1GMYA 4MI7A 2DZYA 3TRKA 5EZSA 5K16A 3H89A 2XU3A 3RNVA 2GFOA 4X6HA 2HWKA 1Q6KA 1EWMA 1F2BA 3WXGA 1IWDA 2E03A 2BTWB 3OQCA 3IFUA 1GCBA 1PPDA 2R9CA 4IUMA 2BDZA 1DF0A 5JA7A 3C9EA 3CBKA 1U9WA 2WBFX 2FRAA 2Z84A 2G6DA 3WXEA 3IUTA 1KFUL 4P16A 4D8EA 1VJVA 2DCBA 1X9YA 4AXMA 2XU4A 3H7DA 4CDDB 3OF9A 4CZWA 3CBJA 3IV2A 2FTDA 2P0RA 3P5XA 1AYUA 1PIPA 2DJFB 3TMPA 2JQGR 5A24A 3LXSA 1SP4B 1QOLA 2AIMA 1M6DA 5JZEA 1F29A 4P6EA 2JTCA 2AYOA 4ZTBA 1O0EA 3CH3X 2B1NA 7PCKA 4FIPA 3PSEA 3P5VA 4ZUXU 1YALA 1NLJA 4RY2A 1AU3A 3BC3A 4BOQA 2DC9A 4BOPA 4G54A 5J94A 4YYSA 9PAPA 1NB3A 2CIOA 2ATOA 2R9MA 4QRXA 4FK5A 1KHPA 3F5VA 3PBHA 1ME3A 2J7QA 3OVXA 1EWOA 4HXDB 2P86A 1VSNA 2JQFR 4FJCA 4N4ZA 1XKGA 3MORA 3DF0A 4OVZA 1U9VA 4KLBA 4XR7A 3HD3A 3BB7A 4CDEB 2DCAA 1AYWA 1CQDA 1F2AA 3H8BA 4XZXA 3NHEA 2VHSA 2BU3A 3K8UA 4OW0A 3HWNA 3I3TA 1ICFA 2P7UA 1KHQA 4PP2E 3V6CA 1AU0A 3K9MA 3TNXA 3AI8A 2AGAA 2FRQA 2YJBA 4DMXA 1KXRA 1YVBA 2DJGB 4CDCB 4Q8GA 2PBHA 1CS8A 2DCCA 1CB5A 2ACTA 2OZ2A 2Y6EA 2E02A 2FO5A 3KW9A 4YYQA 3S3RA 1EWPA 3ZUAA 3WXFA 3IEJA 3E1ZB 1BY8A 4OELA 2AS8A 1ATKA 2DC7A 4QRVA 4I05A 4CDFB 1AIMA 1TLOA 1CSBB 3PDFA 2AUXA 2YJCA 1QMYA 2FT2A 1JQPA 4YYUA 1PADA 1DKIA 2R9FA 3KX1A 4BOUA 2E01A 1U9XA 4M0WA 1PBHA 3B79A 1S4VA 1THEA 1U5IA 3C0RA 5CVOB 3GCBA 5FPWA 1BP4A 2IPPB 2DOSA 4MZSA 4REZA 2OP3A 3KWZA 2UZJA 4BS6A 3I06A 1ZIVA 2DZZA 2E00A 4DMYA 2F1GA 1F2CA 3BY4A 2FE8A 1STFE 3F75A 1YK7A 3N3KA 1YT7A 2PNSA 3KFQA 3O1GA 3MTNA 3PHXA 2FUDA 1CJLA 1EWLA 3O65A 4BOZA 1CTEA 3QSDA 4OVZB 3P5UA 2JRIA 5E6JA 3O0UA 3BBAA 3USVA 1QXPA 1BGOA 3BOWA 4P6GA 2YJ9A 1PPPA 1SNKA 3PT2A 3W30A 3N4CA 1BQIA 1YZBA 2B1MA 3IOQA 4PP1A 1CPJA 3MJ5A 1Y08A 4PT5A 1ME4A 2DC8A 1AU2A 3MHSA 1CVZA 3PRMA 3ZNHA 4HWYA 4BPVA 3ERVA 3HHIA 2NQIA 3M99A 3OVZA 1MS6A 5PADA 1AYVA 3RVVA 4RF1A 3S3QA 2Y5BA 2R9NA 3IMAA 2DCDA 3PRPA 4YVAA 4N8WA 1GLOA 3LFYA 4I07A 1TL9A 4BSQA 3BWKA 2O6XA 4QH6A 2OULA 5EF4A 2FYEA 3QJ3A 2XU5A 3MP2A 3RVWA 2G7YA 2VHFA 5F02A 4WA6A 3V6EA 3QT4A 1EF7A 1MHWA 1MEGA 4W4UA 1NL6A 1UKFA 3K24A 3H8CA 1U9QX 4R3DA 2PREA 2ARYA 4QBBA 2HH5A 2YJ8A 5CVMA 8PCHA 4D8IA 1PPOA 4A5UA 4BS5A 2F7DA 3HHAA 2NQGA 4BOSA 3BPMA 2NQDB 1PE6A 4PI3A 2CB5A 2HHNA 2R9OA 2R6NA 3KSEA 1NQCA 4YV8A 3CH2X 1ITOA 2AYNA 4X6JA 3RVXA 4RF0A 4XUIA 1PCIA 5CHVA 5JH3A 3U8EA 6PADA 4YYVA 4YYRA 3PHUA 1NB5A 1PVJA 5EZQA 2PADA 3KWBX 3IHPA 4BQVA 1HUCB 3OISA 2HD5A 1NPZA 4RKXA 4IP3A 5CHTA 3OF8A 4OEMA 3MTVA 3BPFA 2AUZA 2DC6A 3PNRA 2NQAA 4PADA 1PPNA 5CVNB 2H7JA 4Q8HA 4I04A 5EGWA 5KO3A 4W5CA 4AXLA 4RNAA 3PW3A 2IBIA 1Y4HA 4WURA 4QRGA 3KKUA 4MSXA 1KFXL 1MEMA 3MHHA 1PXVA 4W5BA 2C0YA 2FQ9A 4D8BA 1K3BB 4X6IA 1CV8A 1POPA 1YK8A 2BDLA 2BTWA 3P5WA 4YYWA
chains in the Genus database with same CATH topology
1A6RA 1GECE 3BCNA 2VFBA 1FH0A 1MIRA 3N3GA 2AU1A 4N79A 2HXZA 2XU1A 2AVWA 1AECA 2G8EA 3D6SA 1AU4A 1W4TA 1ZCMA 2G8JA 1MDWA 4MZOA 1TU6A 2YJ2A 4K7CA 2GHUA 1DEUA 3H6SA 1QDQA 1GMYA 2DZYA 3D9WA 5K16A 3H89A 2XU3A 2GFOA 4X6HA 1Q6KA 1EWMA 1F2BA 3WXGA 1IWDA 2E03A 1GCBA 1PPDA 2R9CA 2BDZA 1DF0A 5JA7A 3C9EA 3CBKA 1U9WA 2WBFX 2FRAA 2G6DA 3WXEA 3IUTA 1KFUL 1VJVA 2DCBA 1X9YA 4AXMA 2XU4A 3H7DA 4CDDB 3OF9A 4CZWA 3CBJA 3IV2A 2FTDA 2P0RA 3P5XA 1AYUA 1PIPA 2DJFB 2JQGR 5A24A 3LXSA 1SP4B 1QOLA 2AIMA 1M6DA 1F29A 4P6EA 2AYOA 1O0EA 4NV7A 3CH3X 2B1NA 7PCKA 4FIPA 3P5VA 4ZUXU 1YALA 1NLJA 4RY2A 1AU3A 3BC3A 2DC9A 4G54A 5J94A 4YYSA 9PAPA 1NB3A 2CIOA 2ATOA 2R9MA 4QRXA 4FK5A 1KHPA 3F5VA 3PBHA 1ME3A 3OVXA 1EWOA 2P86A 1VSNA 2JQFR 4FJCA 4NV8A 4N4ZA 1XKGA 3MORA 3DF0A 1U9VA 4KLBA 4XR7A 3HD3A 4B55A 4CDEB 2DCAA 1AYWA 1CQDA 1F2AA 3H8BA 3NHEA 2VHSA 3K8UA 3HWNA 3I3TA 1ICFA 2P7UA 1GX3A 1KHQA 4PP2E 3V6CA 1AU0A 3K9MA 3TNXA 3AI8A 2YJBA 2FRQA 4DMXA 1KXRA 1YVBA 2DJGB 4CDCB 4Q8GA 2PBHA 1CS8A 2DCCA 1CB5A 2ACTA 2OZ2A 2Y6EA 2E02A 2FO5A 3KW9A 4YYQA 3S3RA 1EWPA 3ZUAA 3WXFA 3IEJA 3E1ZB 1BY8A 4OELA 2AS8A 1ATKA 2DC7A 4QRVA 4I05A 4CDFB 1AIMA 1TLOA 1CSBB 3PDFA 2AUXA 2YJCA 1QMYA 2FT2A 1JQPA 4YYUA 1PADA 2R9FA 3KX1A 2E01A 1U9XA 1PBHA 3B79A 1S4VA 1THEA 1U5IA 5CVOB 3GCBA 5FPWA 1BP4A 2IPPB 4MZSA 2OP3A 3KWZA 4BS6A 1E2TA 3I06A 1ZIVA 2DZZA 2E00A 4C5PA 4DMYA 2F1GA 1F2CA 3F75A 1STFE 1YK7A 3N3KA 1YT7A 2PNSA 3KFQA 3O1GA 3MTNA 2FUDA 1CJLA 1EWLA 1CTEA 3QSDA 3P5UA 3O0UA 3USVA 1QXPA 1BGOA 3BOWA 4P6GA 2YJ9A 1PPPA 1SNKA 3N4CA 1BQIA 2B1MA 3IOQA 4PP1A 1CPJA 1Y08A 1ME4A 2DC8A 1AU2A 3MHSA 1CVZA 4HWYA 4BPVA 3ERVA 3HHIA 2NQIA 3M99A 3OVZA 1MS6A 5PADA 1AYVA 3RVVA 3S3QA 2Y5BA 2R9NA 3IMAA 2DCDA 4YVAA 4N8WA 1GLOA 3LFYA 4I07A 1TL9A 3LTWA 4BSQA 3BWKA 2O6XA 4QH6A 2OULA 5EF4A 2FYEA 3QJ3A 2XU5A 3RVWA 2G7YA 2VHFA 5F02A 4WA6A 3V6EA 3QT4A 1EF7A 1MHWA 1MEGA 1W6FA 1NL6A 4W4UA 3K24A 3H8CA 1U9QX 2PREA 2ARYA 4QBBA 2HH5A 2YJ8A 5CVMA 8PCHA 1PPOA 4BS5A 2BSZA 2F7DA 3HHAA 2NQGA 3BPMA 2NQDB 1PE6A 4PI3A 2CB5A 2HHNA 2R9OA 2R6NA 3KSEA 1NQCA 4YV8A 3CH2X 1ITOA 2AYNA 4X6JA 3RVXA 2VFCA 4XUIA 1PCIA 5CHVA 5JH3A 3U8EA 6PADA 4GUZA 4YYVA 4YYRA 1NB5A 2PADA 3KWBX 3IHPA 4BQVA 1HUCB 3OISA 2HD5A 1W5RA 1NPZA 5CHTA 4BGFA 3OF8A 4OEMA 3BPFA 2AUZA 2DC6A 3PNRA 2NQAA 4PADA 1PPNA 5CVNB 2H7JA 4Q8HA 4I04A 5EGWA 4W5CA 4AXLA 3PW3A 2IBIA 1Y4HA 4QRGA 3KKUA 4MSXA 1KFXL 1MEMA 3MHHA 1PXVA 4W5BA 2C0YA 2FQ9A 1K3BB 4X6IA 1CV8A 1POPA 1YK8A 2BDLA 3P5WA 4YYWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A6R A;  1GEC E;  3BCN A;  1FH0 A;  1MIR A;  3N3G A;  2AU1 A;  4N79 A;  2HXZ A;  2XU1 A;  2AVW A;  1AEC A;  2G8E A;  3D6S A;  1AU4 A;  1ZCM A;  2G8J A;  1MDW A;  4MZO A;  1TU6 A;  2YJ2 A;  4K7C A;  2GHU A;  1DEU A;  3H6S A;  1QDQ A;  1GMY A;  2DZY A;  5K16 A;  3H89 A;  2XU3 A;  2GFO A;  4X6H A;  1Q6K A;  1EWM A;  1F2B A;  3WXG A;  1IWD A;  2E03 A;  1GCB A;  1PPD A;  2R9C A;  2BDZ A;  1DF0 A;  5JA7 A;  3C9E A;  3CBK A;  1U9W A;  2WBF X;  2FRA A;  2G6D A;  3WXE A;  3IUT A;  1KFU L;  1VJV A;  2DCB A;  1X9Y A;  4AXM A;  2XU4 A;  3H7D A;  4CDD B;  3OF9 A;  4CZW A;  3CBJ A;  3IV2 A;  2FTD A;  2P0R A;  3P5X A;  1AYU A;  1PIP A;  2DJF B;  2JQG R;  5A24 A;  3LXS A;  1SP4 B;  1QOL A;  2AIM A;  1M6D A;  1F29 A;  4P6E A;  2AYO A;  1O0E A;  3CH3 X;  2B1N A;  7PCK A;  4FIP A;  3P5V A;  4ZUX U;  1YAL A;  1NLJ A;  4RY2 A;  1AU3 A;  3BC3 A;  2DC9 A;  4G54 A;  5J94 A;  4YYS A;  9PAP A;  1NB3 A;  2CIO A;  2ATO A;  2R9M A;  4QRX A;  4FK5 A;  1KHP A;  3F5V A;  3PBH A;  1ME3 A;  3OVX A;  1EWO A;  2P86 A;  1VSN A;  2JQF R;  4FJC A;  4N4Z A;  1XKG A;  3MOR A;  3DF0 A;  1U9V A;  4KLB A;  4XR7 A;  3HD3 A;  4CDE B;  2DCA A;  1AYW A;  1CQD A;  1F2A A;  3H8B A;  3NHE A;  2VHS A;  3K8U A;  3HWN A;  3I3T A;  1ICF A;  2P7U A;  1KHQ A;  4PP2 E;  3V6C A;  1AU0 A;  3K9M A;  3TNX A;  3AI8 A;  2YJB A;  2FRQ A;  4DMX A;  1KXR A;  1YVB A;  2DJG B;  4CDC B;  4Q8G A;  2PBH A;  1CS8 A;  2DCC A;  1CB5 A;  2ACT A;  2OZ2 A;  2Y6E A;  2E02 A;  2FO5 A;  3KW9 A;  4YYQ A;  3S3R A;  1EWP A;  3ZUA A;  3WXF A;  3IEJ A;  3E1Z B;  1BY8 A;  4OEL A;  2AS8 A;  1ATK A;  2DC7 A;  4QRV A;  4I05 A;  4CDF B;  1AIM A;  1TLO A;  1CSB B;  3PDF A;  2AUX A;  2YJC A;  1QMY A;  2FT2 A;  1JQP A;  4YYU A;  1PAD A;  2R9F A;  3KX1 A;  2E01 A;  1U9X A;  1PBH A;  3B79 A;  1S4V A;  1THE A;  1U5I A;  5CVO B;  3GCB A;  5FPW A;  1BP4 A;  2IPP B;  4MZS A;  2OP3 A;  3KWZ A;  4BS6 A;  3I06 A;  1ZIV A;  2DZZ A;  2E00 A;  4DMY A;  2F1G A;  1F2C A;  3F75 A;  1STF E;  1YK7 A;  3N3K A;  1YT7 A;  2PNS A;  3KFQ A;  3O1G A;  3MTN A;  2FUD A;  1CJL A;  1EWL A;  1CTE A;  3QSD A;  3P5U A;  3O0U A;  3USV A;  1QXP A;  1BGO A;  3BOW A;  4P6G A;  2YJ9 A;  1PPP A;  1SNK A;  3N4C A;  1BQI A;  2B1M A;  3IOQ A;  4PP1 A;  1CPJ A;  1Y08 A;  1ME4 A;  2DC8 A;  1AU2 A;  3MHS A;  1CVZ A;  4HWY A;  4BPV A;  3ERV A;  3HHI A;  2NQI A;  3M99 A;  3OVZ A;  1MS6 A;  5PAD A;  1AYV A;  3RVV A;  3S3Q A;  2Y5B A;  2R9N A;  3IMA A;  2DCD A;  4YVA A;  4N8W A;  1GLO A;  3LFY A;  4I07 A;  1TL9 A;  4BSQ A;  3BWK A;  2O6X A;  4QH6 A;  2OUL A;  5EF4 A;  2FYE A;  3QJ3 A;  2XU5 A;  3RVW A;  2G7Y A;  2VHF A;  5F02 A;  4WA6 A;  3V6E A;  3QT4 A;  1EF7 A;  1MHW A;  1MEG A;  4W4U A;  1NL6 A;  3K24 A;  3H8C A;  1U9Q X;  2PRE A;  2ARY A;  4QBB A;  2HH5 A;  2YJ8 A;  5CVM A;  8PCH A;  1PPO A;  4BS5 A;  2F7D A;  3HHA A;  2NQG A;  3BPM A;  2NQD B;  1PE6 A;  4PI3 A;  2CB5 A;  2HHN A;  2R9O A;  2R6N A;  3KSE A;  1NQC A;  4YV8 A;  3CH2 X;  1ITO A;  2AYN A;  4X6J A;  3RVX A;  4XUI A;  1PCI A;  5CHV A;  5JH3 A;  3U8E A;  6PAD A;  4YYV A;  4YYR A;  1NB5 A;  2PAD A;  3KWB X;  3IHP A;  4BQV A;  1HUC B;  3OIS A;  2HD5 A;  1NPZ A;  5CHT A;  3OF8 A;  4OEM A;  3BPF A;  2AUZ A;  2DC6 A;  3PNR A;  2NQA A;  4PAD A;  1PPN A;  5CVN B;  2H7J A;  4Q8H A;  4I04 A;  5EGW A;  4W5C A;  4AXL A;  3PW3 A;  2IBI A;  1Y4H A;  4QRG A;  3KKU A;  4MSX A;  1KFX L;  1MEM A;  3MHH A;  1PXV A;  4W5B A;  2C0Y A;  2FQ9 A;  1K3B B;  4X6I A;  1CV8 A;  1POP A;  1YK8 A;  2BDL A;  3P5W A;  4YYW A; 
#chains in the Genus database with same CATH topology
 1A6R A;  1GEC E;  3BCN A;  1FH0 A;  1MIR A;  3N3G A;  2AU1 A;  4N79 A;  3PHW A;  2HXZ A;  2XU1 A;  2J7Q C;  3E9S A;  2AVW A;  4GUA A;  1AEC A;  2G8E A;  4MM3 B;  3B21 A;  3D6S A;  1AU4 A;  1ZCM A;  2G8J A;  1MDW A;  4MZO A;  1TU6 A;  2YJ2 A;  4K7C A;  2GHU A;  3W31 A;  1DEU A;  3H6S A;  1QDQ A;  1GMY A;  4MI7 A;  2DZY A;  3TRK A;  5EZS A;  5K16 A;  3H89 A;  2XU3 A;  3RNV A;  2GFO A;  4X6H A;  2HWK A;  1Q6K A;  1EWM A;  1F2B A;  3WXG A;  1IWD A;  2E03 A;  2BTW B;  3OQC A;  3IFU A;  1GCB A;  1PPD A;  2R9C A;  4IUM A;  2BDZ A;  1DF0 A;  5JA7 A;  3C9E A;  3CBK A;  1U9W A;  2WBF X;  2FRA A;  2Z84 A;  2G6D A;  3WXE A;  3IUT A;  1KFU L;  4P16 A;  4D8E A;  1VJV A;  2DCB A;  1X9Y A;  4AXM A;  2XU4 A;  3H7D A;  4CDD B;  3OF9 A;  4CZW A;  3CBJ A;  3IV2 A;  2FTD A;  2P0R A;  3P5X A;  1AYU A;  1PIP A;  2DJF B;  3TMP A;  2JQG R;  5A24 A;  3LXS A;  1SP4 B;  1QOL A;  2AIM A;  1M6D A;  5JZE A;  1F29 A;  4P6E A;  2JTC A;  2AYO A;  4ZTB A;  1O0E A;  3CH3 X;  2B1N A;  7PCK A;  4FIP A;  3PSE A;  3P5V A;  4ZUX U;  1YAL A;  1NLJ A;  4RY2 A;  1AU3 A;  3BC3 A;  4BOQ A;  2DC9 A;  4BOP A;  4G54 A;  5J94 A;  4YYS A;  9PAP A;  1NB3 A;  2CIO A;  2ATO A;  2R9M A;  4QRX A;  4FK5 A;  1KHP A;  3F5V A;  3PBH A;  1ME3 A;  2J7Q A;  3OVX A;  1EWO A;  4HXD B;  2P86 A;  1VSN A;  2JQF R;  4FJC A;  4N4Z A;  1XKG A;  3MOR A;  3DF0 A;  4OVZ A;  1U9V A;  4KLB A;  4XR7 A;  3HD3 A;  3BB7 A;  4CDE B;  2DCA A;  1AYW A;  1CQD A;  1F2A A;  3H8B A;  4XZX A;  3NHE A;  2VHS A;  2BU3 A;  3K8U A;  4OW0 A;  3HWN A;  3I3T A;  1ICF A;  2P7U A;  1KHQ A;  4PP2 E;  3V6C A;  1AU0 A;  3K9M A;  3TNX A;  3AI8 A;  2AGA A;  2FRQ A;  2YJB A;  4DMX A;  1KXR A;  1YVB A;  2DJG B;  4CDC B;  4Q8G A;  2PBH A;  1CS8 A;  2DCC A;  1CB5 A;  2ACT A;  2OZ2 A;  2Y6E A;  2E02 A;  2FO5 A;  3KW9 A;  4YYQ A;  3S3R A;  1EWP A;  3ZUA A;  3WXF A;  3IEJ A;  3E1Z B;  1BY8 A;  4OEL A;  2AS8 A;  1ATK A;  2DC7 A;  4QRV A;  4I05 A;  4CDF B;  1AIM A;  1TLO A;  1CSB B;  3PDF A;  2AUX A;  2YJC A;  1QMY A;  2FT2 A;  1JQP A;  4YYU A;  1PAD A;  1DKI A;  2R9F A;  3KX1 A;  4BOU A;  2E01 A;  1U9X A;  4M0W A;  1PBH A;  3B79 A;  1S4V A;  1THE A;  1U5I A;  3C0R A;  5CVO B;  3GCB A;  5FPW A;  1BP4 A;  2IPP B;  2DOS A;  4MZS A;  4REZ A;  2OP3 A;  3KWZ A;  2UZJ A;  4BS6 A;  3I06 A;  1ZIV A;  2DZZ A;  2E00 A;  4DMY A;  2F1G A;  1F2C A;  3BY4 A;  2FE8 A;  1STF E;  3F75 A;  1YK7 A;  3N3K A;  1YT7 A;  2PNS A;  3KFQ A;  3O1G A;  3MTN A;  3PHX A;  2FUD A;  1CJL A;  1EWL A;  3O65 A;  4BOZ A;  1CTE A;  3QSD A;  4OVZ B;  3P5U A;  2JRI A;  5E6J A;  3O0U A;  3BBA A;  3USV A;  1QXP A;  1BGO A;  3BOW A;  4P6G A;  2YJ9 A;  1PPP A;  1SNK A;  3PT2 A;  3W30 A;  3N4C A;  1BQI A;  1YZB A;  2B1M A;  3IOQ A;  4PP1 A;  1CPJ A;  3MJ5 A;  1Y08 A;  4PT5 A;  1ME4 A;  2DC8 A;  1AU2 A;  3MHS A;  1CVZ A;  3PRM A;  3ZNH A;  4HWY A;  4BPV A;  3ERV A;  3HHI A;  2NQI A;  3M99 A;  3OVZ A;  1MS6 A;  5PAD A;  1AYV A;  3RVV A;  4RF1 A;  3S3Q A;  2Y5B A;  2R9N A;  3IMA A;  2DCD A;  3PRP A;  4YVA A;  4N8W A;  1GLO A;  3LFY A;  4I07 A;  1TL9 A;  4BSQ A;  3BWK A;  2O6X A;  4QH6 A;  2OUL A;  5EF4 A;  2FYE A;  3QJ3 A;  2XU5 A;  3MP2 A;  3RVW A;  2G7Y A;  2VHF A;  5F02 A;  4WA6 A;  3V6E A;  3QT4 A;  1EF7 A;  1MHW A;  1MEG A;  4W4U A;  1NL6 A;  1UKF A;  3K24 A;  3H8C A;  1U9Q X;  4R3D A;  2PRE A;  2ARY A;  4QBB A;  2HH5 A;  2YJ8 A;  5CVM A;  8PCH A;  4D8I A;  1PPO A;  4A5U A;  4BS5 A;  2F7D A;  3HHA A;  2NQG A;  4BOS A;  3BPM A;  2NQD B;  1PE6 A;  4PI3 A;  2CB5 A;  2HHN A;  2R9O A;  2R6N A;  3KSE A;  1NQC A;  4YV8 A;  3CH2 X;  1ITO A;  2AYN A;  4X6J A;  3RVX A;  4RF0 A;  4XUI A;  1PCI A;  5CHV A;  5JH3 A;  3U8E A;  6PAD A;  4YYV A;  4YYR A;  3PHU A;  1NB5 A;  1PVJ A;  5EZQ A;  2PAD A;  3KWB X;  3IHP A;  4BQV A;  1HUC B;  3OIS A;  2HD5 A;  1NPZ A;  4RKX A;  4IP3 A;  5CHT A;  3OF8 A;  4OEM A;  3MTV A;  3BPF A;  2AUZ A;  2DC6 A;  3PNR A;  2NQA A;  4PAD A;  1PPN A;  5CVN B;  2H7J A;  4Q8H A;  4I04 A;  5EGW A;  5KO3 A;  4W5C A;  4AXL A;  4RNA A;  3PW3 A;  2IBI A;  1Y4H A;  4WUR A;  4QRG A;  3KKU A;  4MSX A;  1KFX L;  1MEM A;  3MHH A;  1PXV A;  4W5B A;  2C0Y A;  2FQ9 A;  4D8B A;  1K3B B;  4X6I A;  1CV8 A;  1POP A;  1YK8 A;  2BDL A;  2BTW A;  3P5W A;  4YYW A; 
#chains in the Genus database with same CATH homology
 1A6R A;  1GEC E;  3BCN A;  2VFB A;  1FH0 A;  1MIR A;  3N3G A;  2AU1 A;  4N79 A;  2HXZ A;  2XU1 A;  2AVW A;  1AEC A;  2G8E A;  3D6S A;  1AU4 A;  1W4T A;  1ZCM A;  2G8J A;  1MDW A;  4MZO A;  1TU6 A;  2YJ2 A;  4K7C A;  2GHU A;  1DEU A;  3H6S A;  1QDQ A;  1GMY A;  2DZY A;  3D9W A;  5K16 A;  3H89 A;  2XU3 A;  2GFO A;  4X6H A;  1Q6K A;  1EWM A;  1F2B A;  3WXG A;  1IWD A;  2E03 A;  1GCB A;  1PPD A;  2R9C A;  2BDZ A;  1DF0 A;  5JA7 A;  3C9E A;  3CBK A;  1U9W A;  2WBF X;  2FRA A;  2G6D A;  3WXE A;  3IUT A;  1KFU L;  1VJV A;  2DCB A;  1X9Y A;  4AXM A;  2XU4 A;  3H7D A;  4CDD B;  3OF9 A;  4CZW A;  3CBJ A;  3IV2 A;  2FTD A;  2P0R A;  3P5X A;  1AYU A;  1PIP A;  2DJF B;  2JQG R;  5A24 A;  3LXS A;  1SP4 B;  1QOL A;  2AIM A;  1M6D A;  1F29 A;  4P6E A;  2AYO A;  1O0E A;  4NV7 A;  3CH3 X;  2B1N A;  7PCK A;  4FIP A;  3P5V A;  4ZUX U;  1YAL A;  1NLJ A;  4RY2 A;  1AU3 A;  3BC3 A;  2DC9 A;  4G54 A;  5J94 A;  4YYS A;  9PAP A;  1NB3 A;  2CIO A;  2ATO A;  2R9M A;  4QRX A;  4FK5 A;  1KHP A;  3F5V A;  3PBH A;  1ME3 A;  3OVX A;  1EWO A;  2P86 A;  1VSN A;  2JQF R;  4FJC A;  4NV8 A;  4N4Z A;  1XKG A;  3MOR A;  3DF0 A;  1U9V A;  4KLB A;  4XR7 A;  3HD3 A;  4B55 A;  4CDE B;  2DCA A;  1AYW A;  1CQD A;  1F2A A;  3H8B A;  3NHE A;  2VHS A;  3K8U A;  3HWN A;  3I3T A;  1ICF A;  2P7U A;  1GX3 A;  1KHQ A;  4PP2 E;  3V6C A;  1AU0 A;  3K9M A;  3TNX A;  3AI8 A;  2YJB A;  2FRQ A;  4DMX A;  1KXR A;  1YVB A;  2DJG B;  4CDC B;  4Q8G A;  2PBH A;  1CS8 A;  2DCC A;  1CB5 A;  2ACT A;  2OZ2 A;  2Y6E A;  2E02 A;  2FO5 A;  3KW9 A;  4YYQ A;  3S3R A;  1EWP A;  3ZUA A;  3WXF A;  3IEJ A;  3E1Z B;  1BY8 A;  4OEL A;  2AS8 A;  1ATK A;  2DC7 A;  4QRV A;  4I05 A;  4CDF B;  1AIM A;  1TLO A;  1CSB B;  3PDF A;  2AUX A;  2YJC A;  1QMY A;  2FT2 A;  1JQP A;  4YYU A;  1PAD A;  2R9F A;  3KX1 A;  2E01 A;  1U9X A;  1PBH A;  3B79 A;  1S4V A;  1THE A;  1U5I A;  5CVO B;  3GCB A;  5FPW A;  1BP4 A;  2IPP B;  4MZS A;  2OP3 A;  3KWZ A;  4BS6 A;  1E2T A;  3I06 A;  1ZIV A;  2DZZ A;  2E00 A;  4C5P A;  4DMY A;  2F1G A;  1F2C A;  3F75 A;  1STF E;  1YK7 A;  3N3K A;  1YT7 A;  2PNS A;  3KFQ A;  3O1G A;  3MTN A;  2FUD A;  1CJL A;  1EWL A;  1CTE A;  3QSD A;  3P5U A;  3O0U A;  3USV A;  1QXP A;  1BGO A;  3BOW A;  4P6G A;  2YJ9 A;  1PPP A;  1SNK A;  3N4C A;  1BQI A;  2B1M A;  3IOQ A;  4PP1 A;  1CPJ A;  1Y08 A;  1ME4 A;  2DC8 A;  1AU2 A;  3MHS A;  1CVZ A;  4HWY A;  4BPV A;  3ERV A;  3HHI A;  2NQI A;  3M99 A;  3OVZ A;  1MS6 A;  5PAD A;  1AYV A;  3RVV A;  3S3Q A;  2Y5B A;  2R9N A;  3IMA A;  2DCD A;  4YVA A;  4N8W A;  1GLO A;  3LFY A;  4I07 A;  1TL9 A;  3LTW A;  4BSQ A;  3BWK A;  2O6X A;  4QH6 A;  2OUL A;  5EF4 A;  2FYE A;  3QJ3 A;  2XU5 A;  3RVW A;  2G7Y A;  2VHF A;  5F02 A;  4WA6 A;  3V6E A;  3QT4 A;  1EF7 A;  1MHW A;  1MEG A;  1W6F A;  1NL6 A;  4W4U A;  3K24 A;  3H8C A;  1U9Q X;  2PRE A;  2ARY A;  4QBB A;  2HH5 A;  2YJ8 A;  5CVM A;  8PCH A;  1PPO A;  4BS5 A;  2BSZ A;  2F7D A;  3HHA A;  2NQG A;  3BPM A;  2NQD B;  1PE6 A;  4PI3 A;  2CB5 A;  2HHN A;  2R9O A;  2R6N A;  3KSE A;  1NQC A;  4YV8 A;  3CH2 X;  1ITO A;  2AYN A;  4X6J A;  3RVX A;  2VFC A;  4XUI A;  1PCI A;  5CHV A;  5JH3 A;  3U8E A;  6PAD A;  4GUZ A;  4YYV A;  4YYR A;  1NB5 A;  2PAD A;  3KWB X;  3IHP A;  4BQV A;  1HUC B;  3OIS A;  2HD5 A;  1W5R A;  1NPZ A;  5CHT A;  4BGF A;  3OF8 A;  4OEM A;  3BPF A;  2AUZ A;  2DC6 A;  3PNR A;  2NQA A;  4PAD A;  1PPN A;  5CVN B;  2H7J A;  4Q8H A;  4I04 A;  5EGW A;  4W5C A;  4AXL A;  3PW3 A;  2IBI A;  1Y4H A;  4QRG A;  3KKU A;  4MSX A;  1KFX L;  1MEM A;  3MHH A;  1PXV A;  4W5B A;  2C0Y A;  2FQ9 A;  1K3B B;  4X6I A;  1CV8 A;  1POP A;  1YK8 A;  2BDL A;  3P5W A;  4YYW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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