1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
molecule keywords pyrogenic exotoxin B
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
1PVJA 1DKIA 4RKXA 3BBAA 3BB7A 4D8IA 2JTCA 2UZJA 4D8EA 4D8BA
chains in the Genus database with same CATH superfamily
1PE6A 2JQGR 2AUXA 6PADA 3HWNA 3BWKA 2J7QA 1Y08A 4BOQA 2C0YA 3BPFA 3HD3A 3I06A 1NL6A 1QMYA 3O1GA 3OF9A 5JA7A 2G7YA 3N3KA 1EWPA 1ITOA 1YK8A 2OP3A 3RNVA 1PBHA 2R9FA 4MM3B 3P5VA 2DCBA 4GUAA 2AVWA 3NHEA 2P7UA 2H7JA 3H8CA 3IOQA 1PXVA 1Q6KA 3F5VA 5KO3A 2J7QC 2HXZA 2AYNA 2ATOA 4P16A 1TLOA 1EWOA 4MI7A 2F7DA 5EZQA 2P86A 1CTEA 2DC9A 1PIPA 1GLOA 2NQAA 4PADA 1GECE 2FRQA 3PHXA 4Q8GA 3PDFA 2HH5A 3F75A 3HHAA 2DOSA 1Y4HA 4CDDB 1NQCA 4RF1A 2FUDA 2G6DA 4XUIA 3S3RA 1ZIVA 3IHPA 4BSQA 1K3BB 1SNKA 9PAPA 3LFYA 3N3GA 2PBHA 1AECA 3QSDA 3CH2X 3PRPA 2CB5A 2DC7A 3PSEA 2Y5BA 1PPDA 3S3QA 4XR7A 2UZJA 2HWKA 4X6JA 2XU5A 3LXSA 4FK5A 3USVA 4ZTBA 3C9EA 1PPOA 2XU1A 7PCKA 1U9QX 2YJBA 3H6SA 3K9MA 4MSXA 3N4CA 5JH3A 3WXEA 2G8EA 4KQTA 2VHSA 4REZA 1THEA 3IV2A 4R3DA 2FO5A 2R6NA 5CHTA 3D6SA 1MEMA 2AS8A 1PVJA 1DKIA 2DCCA 3MJ5A 1ICFA 4OVZA 5CHVA 1BGOA 3KW9A 3B21A 2OZ2A 3OQCA 4W5CA 5EZSA 2AIMA 4OVZB 1ME3A 2BU3A 5A24A 1NPZA 1YK7A 3W30A 4P6GA 2R9NA 2YJCA 4MZOA 4N79A 2JTCA 4PI3A 2FT2A 4QH6A 4BOUA 3MHHA 1JQPA 1CJLA 1ATKA 1IWDA 4BS6A 4CDCB 2VHFA 8PCHA 2DCDA 2BTWA 3MORA 2IBIA 1AIMA 3CH3X 4CDFB 5JZEA 4Q8HA 4YYSA 4I05A 1GHHA 4QBBA 3BB7A 2ARYA 3CBJA 1CS8A 1PPPA 2AUZA 1GCBA 1AU0A 1X9YA 5F02A 2HD5A 4N4ZA 2HHNA 2YJ8A 1TU6A 1CVZA 2PREA 3H7DA 1NB5A 4W5BA 3MP2A 2B1NA 3E1ZB 4P6EA 2BDLA 4K7CA 3B79A 1NB3A 2NQDB 2F1GA 2E01A 3IEJA 1AU3A 2DZZA 3QT4A 3KFQA 2PADA 2JRIA 4I07A 4WURA 3AI8A 3KKUA 4ZUXU 1VJVA 4DMYA 1AYVA 5K16A 1DF0A 3KSEA 4RKXA 3M99A 1AYUA 4MZSA 3QJ3A 3BOWA 4X6HA 2Z84A 3CBKA 3PHWA 3PT2A 5EGWA 4QRGA 3P5XA 4PP1A 3OF8A 1BY8A 3MTVA 1STFE 3H89A 1CPJA 3ERVA 2BTWB 3U8EA 4YYRA 5E6JA 3O0UA 3PHUA 4D8BA 4BOSA 1MIRA 3BPMA 3PRMA 1F2CA 4OEMA 4G54A 1BP4A 2BDZA 4IUMA 2FE8A 3GCBA 1NLJA 2WBFX 4BOPA 3TMPA 3BBAA 1S4VA 4RF0A 3MHSA 4BPVA 3PNRA 3KWZA 2YJ2A 2IPPB 1CQDA 3TNXA 2B1MA 3IUTA 3KWBX 4AXLA 1A6RA 4YV8A 5PADA 4BQVA 3ZUAA 2DC8A 1TL9A 1SP4B 2OULA 1HUCB 1U9XA 3I3TA 1EWLA 3OVZA 4AXMA 3HHIA 1KXRA 4PT5A 4D8EA 4M0WA 4CDEB 3P5UA 1BQIA 4WA6A 2DCAA 1YZBA 4QRVA 4I04A 4RY2A 4YYQA 1CV8A 2CIOA 5CVMA 3OISA 3BCNA 3P5WA 2DZYA 2PNSA 4HXDB 4EVXA 2R9OA 1FH0A 2E03A 1QOLA 3H8BA 4RNAA 4YYVA 1MEGA 2R9MA 3V6CA 1CB5A 3WXGA 2DC6A 1PADA 3K8UA 1GMYA 4IP3A 1MS6A 4BOZA 1F29A 1U5IA 4QRXA 2FRAA 1KHQA 2DJFB 3RVXA 3BY4A 1MHWA 1DEUA 3V6EA 2GFOA 4FJCA 1PPNA 2AYOA 3MTNA 1QXPA 4XZXA 3C0RA 3DF0A 1VSNA 4PP2E 5EF4A 2NQIA 3KX1A 3W31A 1O0EA 2FQ9A 2XU4A 2FTDA 1M6DA 1F2BA 2O6XA 3K24A 1EWMA 3PBHA 1XKGA 2Y6EA 1EF7A 1KFXL 4DMXA 5J94A 2FYEA 4A5UA 2ACTA 2YJ9A 1PCIA 2GHUA 1U9VA 3BC3A 3O65A 3RVWA 1CSBB 4N8WA 2NQGA 3WXFA 4KLBA 3E9SA 3OVXA 1MDWA 5CVNB 1KFUL 2R9CA 4FIPA 4W4UA 2P0RA 4X6IA 4YYWA 1SG2A 4HWYA 1KHPA 2JQFR 3RVVA 4D8IA 2E00A 1QDQA 1F2AA 2AU1A 1U2MA 4OELA 2DJGB 1YALA 1POPA 1AU4A 3IMAA 5FPWA 4YVAA 4BS5A 1YT7A 4YYUA 3IFUA 1ZCMA 3TRKA 4CZWA 1YVBA 1ME4A 4OW0A 2G8JA 2AGAA 5CVOB 2XU3A 1UKFA 3ZNHA 1AYWA 2E02A 1AU2A 1U9WA 3PW3A
chains in the Genus database with same CATH topology
4M0WA 3O65A 4RNAA 3RNVA 4RKXA 3B21A 4MM3B 3MP2A 3PRPA 2BTWA 5E6JA 3PSEA 3PHUA 2J7QA 3PHXA 4GUAA 2Z84A 4BOSA 3W31A 4BOQA 4D8BA 3OQCA 3E9SA 3PRMA 3PHWA 3PT2A 5EZSA 4REZA 4OVZB 1YZBA 2BU3A 4IP3A 5JZEA 2UZJA 2DOSA 4R3DA 4BOZA 2HWKA 4IUMA 4RF1A 5KO3A 2J7QC 3W30A 3IFUA 2FE8A 3TRKA 3BB7A 2JRIA 3BY4A 2JTCA 4WURA 4OW0A 4ZTBA 3MTVA 4P16A 1PVJA 2AGAA 1DKIA 4BOUA 3TMPA 3MJ5A 4BOPA 3BBAA 4MI7A 1UKFA 3ZNHA 4HXDB 4PT5A 4A5UA 5EZQA 4EVXA 4OVZA 3C0RA 4RF0A 4XZXA 4D8IA 2BTWB 4D8EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PVJ A;  1DKI A;  4RKX A;  3BBA A;  3BB7 A;  4D8I A;  2JTC A;  2UZJ A;  4D8E A;  4D8B A; 
#chains in the Genus database with same CATH topology
 1PE6 A;  2JQG R;  2AUX A;  6PAD A;  3HWN A;  3BWK A;  2J7Q A;  1Y08 A;  4BOQ A;  2C0Y A;  3BPF A;  3HD3 A;  3I06 A;  1NL6 A;  1QMY A;  3O1G A;  3OF9 A;  5JA7 A;  2G7Y A;  3N3K A;  1EWP A;  1ITO A;  1YK8 A;  2OP3 A;  3RNV A;  1PBH A;  2R9F A;  4MM3 B;  3P5V A;  2DCB A;  4GUA A;  2AVW A;  3NHE A;  2P7U A;  2H7J A;  3H8C A;  3IOQ A;  1PXV A;  1Q6K A;  3F5V A;  5KO3 A;  2J7Q C;  2HXZ A;  2AYN A;  2ATO A;  4P16 A;  1TLO A;  1EWO A;  4MI7 A;  2F7D A;  5EZQ A;  2P86 A;  1CTE A;  2DC9 A;  1PIP A;  1GLO A;  2NQA A;  4PAD A;  1GEC E;  2FRQ A;  3PHX A;  4Q8G A;  3PDF A;  2HH5 A;  3F75 A;  3HHA A;  2DOS A;  1Y4H A;  4CDD B;  1NQC A;  4RF1 A;  2FUD A;  2G6D A;  4XUI A;  3S3R A;  1ZIV A;  3IHP A;  4BSQ A;  1K3B B;  1SNK A;  9PAP A;  3LFY A;  3N3G A;  2PBH A;  1AEC A;  3QSD A;  3CH2 X;  3PRP A;  2CB5 A;  2DC7 A;  3PSE A;  2Y5B A;  1PPD A;  3S3Q A;  4XR7 A;  2UZJ A;  2HWK A;  4X6J A;  2XU5 A;  3LXS A;  4FK5 A;  3USV A;  4ZTB A;  3C9E A;  1PPO A;  2XU1 A;  7PCK A;  1U9Q X;  2YJB A;  3H6S A;  3K9M A;  4MSX A;  3N4C A;  5JH3 A;  3WXE A;  2G8E A;  4KQT A;  2VHS A;  4REZ A;  1THE A;  3IV2 A;  4R3D A;  2FO5 A;  2R6N A;  5CHT A;  3D6S A;  1MEM A;  2AS8 A;  1PVJ A;  1DKI A;  2DCC A;  3MJ5 A;  1ICF A;  4OVZ A;  5CHV A;  1BGO A;  3KW9 A;  3B21 A;  2OZ2 A;  3OQC A;  4W5C A;  5EZS A;  2AIM A;  4OVZ B;  1ME3 A;  2BU3 A;  5A24 A;  1NPZ A;  1YK7 A;  3W30 A;  4P6G A;  2R9N A;  2YJC A;  4MZO A;  4N79 A;  2JTC A;  4PI3 A;  2FT2 A;  4QH6 A;  4BOU A;  3MHH A;  1JQP A;  1CJL A;  1ATK A;  1IWD A;  4BS6 A;  4CDC B;  2VHF A;  8PCH A;  2DCD A;  2BTW A;  3MOR A;  2IBI A;  1AIM A;  3CH3 X;  4CDF B;  5JZE A;  4Q8H A;  4YYS A;  4I05 A;  1GHH A;  4QBB A;  3BB7 A;  2ARY A;  3CBJ A;  1CS8 A;  1PPP A;  2AUZ A;  1GCB A;  1AU0 A;  1X9Y A;  5F02 A;  2HD5 A;  4N4Z A;  2HHN A;  2YJ8 A;  1TU6 A;  1CVZ A;  2PRE A;  3H7D A;  1NB5 A;  4W5B A;  3MP2 A;  2B1N A;  3E1Z B;  4P6E A;  2BDL A;  4K7C A;  3B79 A;  1NB3 A;  2NQD B;  2F1G A;  2E01 A;  3IEJ A;  1AU3 A;  2DZZ A;  3QT4 A;  3KFQ A;  2PAD A;  2JRI A;  4I07 A;  4WUR A;  3AI8 A;  3KKU A;  4ZUX U;  1VJV A;  4DMY A;  1AYV A;  5K16 A;  1DF0 A;  3KSE A;  4RKX A;  3M99 A;  1AYU A;  4MZS A;  3QJ3 A;  3BOW A;  4X6H A;  2Z84 A;  3CBK A;  3PHW A;  3PT2 A;  5EGW A;  4QRG A;  3P5X A;  4PP1 A;  3OF8 A;  1BY8 A;  3MTV A;  1STF E;  3H89 A;  1CPJ A;  3ERV A;  2BTW B;  3U8E A;  4YYR A;  5E6J A;  3O0U A;  3PHU A;  4D8B A;  4BOS A;  1MIR A;  3BPM A;  3PRM A;  1F2C A;  4OEM A;  4G54 A;  1BP4 A;  2BDZ A;  4IUM A;  2FE8 A;  3GCB A;  1NLJ A;  2WBF X;  4BOP A;  3TMP A;  3BBA A;  1S4V A;  4RF0 A;  3MHS A;  4BPV A;  3PNR A;  3KWZ A;  2YJ2 A;  2IPP B;  1CQD A;  3TNX A;  2B1M A;  3IUT A;  3KWB X;  4AXL A;  1A6R A;  4YV8 A;  5PAD A;  4BQV A;  3ZUA A;  2DC8 A;  1TL9 A;  1SP4 B;  2OUL A;  1HUC B;  1U9X A;  3I3T A;  1EWL A;  3OVZ A;  4AXM A;  3HHI A;  1KXR A;  4PT5 A;  4D8E A;  4M0W A;  4CDE B;  3P5U A;  1BQI A;  4WA6 A;  2DCA A;  1YZB A;  4QRV A;  4I04 A;  4RY2 A;  4YYQ A;  1CV8 A;  2CIO A;  5CVM A;  3OIS A;  3BCN A;  3P5W A;  2DZY A;  2PNS A;  4HXD B;  4EVX A;  2R9O A;  1FH0 A;  2E03 A;  1QOL A;  3H8B A;  4RNA A;  4YYV A;  1MEG A;  2R9M A;  3V6C A;  1CB5 A;  3WXG A;  2DC6 A;  1PAD A;  3K8U A;  1GMY A;  4IP3 A;  1MS6 A;  4BOZ A;  1F29 A;  1U5I A;  4QRX A;  2FRA A;  1KHQ A;  2DJF B;  3RVX A;  3BY4 A;  1MHW A;  1DEU A;  3V6E A;  2GFO A;  4FJC A;  1PPN A;  2AYO A;  3MTN A;  1QXP A;  4XZX A;  3C0R A;  3DF0 A;  1VSN A;  4PP2 E;  5EF4 A;  2NQI A;  3KX1 A;  3W31 A;  1O0E A;  2FQ9 A;  2XU4 A;  2FTD A;  1M6D A;  1F2B A;  2O6X A;  3K24 A;  1EWM A;  3PBH A;  1XKG A;  2Y6E A;  1EF7 A;  1KFX L;  4DMX A;  5J94 A;  2FYE A;  4A5U A;  2ACT A;  2YJ9 A;  1PCI A;  2GHU A;  1U9V A;  3BC3 A;  3O65 A;  3RVW A;  1CSB B;  4N8W A;  2NQG A;  3WXF A;  4KLB A;  3E9S A;  3OVX A;  1MDW A;  5CVN B;  1KFU L;  2R9C A;  4FIP A;  4W4U A;  2P0R A;  4X6I A;  4YYW A;  1SG2 A;  4HWY A;  1KHP A;  2JQF R;  3RVV A;  4D8I A;  2E00 A;  1QDQ A;  1F2A A;  2AU1 A;  1U2M A;  4OEL A;  2DJG B;  1YAL A;  1POP A;  1AU4 A;  3IMA A;  5FPW A;  4YVA A;  4BS5 A;  1YT7 A;  4YYU A;  3IFU A;  1ZCM A;  3TRK A;  4CZW A;  1YVB A;  1ME4 A;  4OW0 A;  2G8J A;  2AGA A;  5CVO B;  2XU3 A;  1UKF A;  3ZNH A;  1AYW A;  2E02 A;  1AU2 A;  1U9W A;  3PW3 A; 
#chains in the Genus database with same CATH homology
 4M0W A;  3O65 A;  4RNA A;  3RNV A;  4RKX A;  3B21 A;  4MM3 B;  3MP2 A;  3PRP A;  2BTW A;  5E6J A;  3PSE A;  3PHU A;  2J7Q A;  3PHX A;  4GUA A;  2Z84 A;  4BOS A;  3W31 A;  4BOQ A;  4D8B A;  3OQC A;  3E9S A;  3PRM A;  3PHW A;  3PT2 A;  5EZS A;  4REZ A;  4OVZ B;  1YZB A;  2BU3 A;  4IP3 A;  5JZE A;  2UZJ A;  2DOS A;  4R3D A;  4BOZ A;  2HWK A;  4IUM A;  4RF1 A;  5KO3 A;  2J7Q C;  3W30 A;  3IFU A;  2FE8 A;  3TRK A;  3BB7 A;  2JRI A;  3BY4 A;  2JTC A;  4WUR A;  4OW0 A;  4ZTB A;  3MTV A;  4P16 A;  1PVJ A;  2AGA A;  1DKI A;  4BOU A;  3TMP A;  3MJ5 A;  4BOP A;  3BBA A;  4MI7 A;  1UKF A;  3ZNH A;  4HXD B;  4PT5 A;  4A5U A;  5EZQ A;  4EVX A;  4OVZ A;  3C0R A;  4RF0 A;  4XZX A;  4D8I A;  2BTW B;  4D8E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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