1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords pyrogenic exotoxin B
publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
1DKIA 4D8EA 3BBAA 3BB7A 4D8BA 4D8IA 4RKXA 1PVJA 2UZJA 2JTCA
chains in the Genus database with same CATH superfamily
1KHPA 3O0UA 1ATKA 2C0YA 2R9OA 4I05A 3CH3X 4CDFB 1YK8A 3KKUA 3N3KA 4RF1A 4BS5A 3W30A 2YJ8A 1PXVA 1QMYA 3HWNA 1KFUL 2DCAA 2XU1A 2BTWB 2G7YA 3F75A 4HWYA 5CVMA 1BQIA 1ZIVA 4D8EA 3QJ3A 1MIRA 1CSBB 4D8BA 1TL9A 4Q8GA 3ZUAA 3TRKA 1MDWA 2G8EA 1MEMA 4RNAA 2FUDA 3P5WA 4CDCB 3WXEA 3IHPA 4P6GA 4OVZA 2XU5A 4WURA 2IPPB 4KLBA 1EF7A 3MTVA 3QT4A 3S3QA 4HXDB 3PSEA 1ITOA 2P7UA 1Y08A 3KSEA 3WXFA 1AYVA 1GCBA 4W5CA 4AXLA 2BDLA 5JA7A 3E1ZB 4PT5A 3P5XA 2VHFA 2G8JA 1CPJA 4MI7A 2Y6EA 4BOSA 1BP4A 2HXZA 3KFQA 2FRQA 4K7CA 4YV8A 9PAPA 2E01A 4FIPA 4N79A 2B1MA 5CVOB 3PBHA 1VJVA 3BC3A 2AUZA 4P6EA 2AU1A 3BPMA 3P5VA 1ZCMA 1KHQA 3HD3A 3WXGA 3RNVA 4DMXA 5EGWA 2JTCA 2DZYA 2FTDA 7PCKA 3IUTA 1EWLA 3V6EA 2AIMA 1GHHA 3BBAA 1CTEA 3V6CA 1HUCB 1QDQA 1TLOA 1NB3A 1PIPA 2R6NA 3U8EA 5F02A 1YK7A 1PPDA 2NQGA 2DOSA 2DJFB 1NLJA 3D6SA 1QOLA 2AYNA 3P5UA 3BOWA 2ACTA 3GCBA 5JH3A 4RY2A 4I07A 3CBKA 4X6JA 1QXPA 3KWBX 2Z84A 2YJ9A 3OVZA 2FRAA 5PADA 3PHUA 2IBIA 4YYUA 4OW0A 3H8BA 3DF0A 2PNSA 4R3DA 5EF4A 3K24A 2PREA 3USVA 2E03A 2NQDB 2YJCA 3B21A 2HHNA 1PBHA 3QSDA 2HH5A 2HWKA 1NB5A 3C0RA 2DC7A 1PE6A 4DMYA 2AVWA 1MHWA 4X6HA 3OQCA 4ZTBA 1BY8A 1AIMA 2DCDA 4QH6A 3PRMA 4YYRA 1PPOA 4KQTA 1SG2A 3E9SA 1PVJA 1U2MA 1FH0A 1DF0A 4W4UA 4FJCA 4XR7A 3ZNHA 4CDEB 1F2CA 3IEJA 1VSNA 1YZBA 3OISA 2NQIA 2BDZA 2AGAA 3BCNA 2R9FA 4BOUA 1U5IA 1ICFA 2FQ9A 1U9QX 2DCBA 1U9WA 4BOZA 4GUAA 4PP1A 4OVZB 4D8IA 3OVXA 4RKXA 2H7JA 6PADA 1MEGA 4MZOA 5KO3A 1NPZA 2OP3A 4WA6A 4AXMA 1THEA 3BWKA 2R9NA 4MSXA 2BU3A 2G6DA 2DZZA 2DC6A 2O6XA 5J94A 3M99A 4Q8HA 2YJBA 1JQPA 3B79A 3H8CA 2P86A 3IFUA 3MORA 3IMAA 1Q6KA 2CIOA 1KFXL 1A6RA 3I06A 2E02A 1AYWA 1PPPA 1POPA 3BY4A 1U9VA 1F2BA 1EWOA 3NHEA 3MHSA 5EZQA 2BTWA 2HD5A 2WBFX 2DC9A 2JQGR 5K16A 2R9CA 1CJLA 3LFYA 1SP4B 1GMYA 3LXSA 1CS8A 1EWPA 5A24A 3K8UA 3MTNA 2CB5A 3MP2A 4P16A 4IP3A 4YYSA 1EWMA 1CVZA 1UKFA 1IWDA 5E6JA 3MHHA 1PADA 3KWZA 2OULA 3PHWA 2P0RA 4BS6A 3C9EA 3KX1A 2AUXA 4QBBA 4YYQA 3ERVA 1PPNA 1CB5A 3H6SA 3N3GA 3CBJA 2PADA 3BB7A 3PW3A 1O0EA 4G54A 4N4ZA 3MJ5A 4REZA 2DJGB 3OF9A 3S3RA 1DEUA 2XU3A 3HHAA 5CVNB 4W5BA 2AS8A 1CV8A 1ME3A 4FK5A 4I04A 4CZWA 2FE8A 4XUIA 4PI3A 1XKGA 3H7DA 4QRGA 3CH2X 2R9MA 1M6DA 3O1GA 3AI8A 3W31A 5FPWA 4OEMA 1X9YA 2JQFR 1SNKA 3PT2A 2ATOA 4CDDB 1BGOA 1AYUA 2ARYA 4BPVA 1TU6A 2B1NA 2OZ2A 3PNRA 2J7QA 3N4CA 4BOQA 3TNXA 4RF0A 1AU4A 4YYVA 4YVAA 2FYEA 4PP2E 1MS6A 4OELA 2F1GA 1Y4HA 2NQAA 1AU0A 3RVXA 3O65A 2YJ2A 4MZSA 4QRVA 4M0WA 3H89A 5EZSA 1PCIA 5JZEA 1GECE 4QRXA 2DC8A 3F5VA 3K9MA 4X6IA 4MM3B 2DCCA 4A5UA 1AECA 2UZJA 3HHIA 3OF8A 4BOPA 2E00A 4YYWA 3I3TA 4N8WA 8PCHA 1F2AA 1GLOA 2J7QC 4XZXA 1CQDA 1DKIA 2AYOA 1S4VA 2FT2A 1U9XA 1K3BB 1AU3A 3IV2A 3PDFA 3PHXA 4IUMA 2VHSA 1NL6A 5CHTA 2Y5BA 4ZUXU 1F29A 3BPFA 2GFOA 4PADA 2FO5A 3PRPA 2F7DA 4BSQA 1YALA 3IOQA 1YT7A 5CHVA 2XU4A 4BQVA 1NQCA 1KXRA 3RVWA 2PBHA 3RVVA 1YVBA 1AU2A 3KW9A 1ME4A 3TMPA 1STFE 4EVXA 2GHUA 2JRIA
chains in the Genus database with same CATH topology
4BOZA 3RNVA 4GUAA 4OVZB 4D8IA 4RKXA 2FE8A 4RF1A 2JTCA 3W30A 5KO3A 2BTWB 3BBAA 2BU3A 3W31A 4D8EA 3PT2A 4D8BA 3TRKA 2DOSA 3IFUA 2J7QA 4BOQA 4RF0A 4RNAA 3BY4A 4OVZA 3O65A 2Z84A 4M0WA 5EZSA 4WURA 5JZEA 5EZQA 3PHUA 2BTWA 3MTVA 4OW0A 4HXDB 3PSEA 4MM3B 4R3DA 4A5UA 2UZJA 4BOPA 3B21A 2HWKA 4XZXA 2J7QC 4EVXA 3C0RA 4PT5A 1DKIA 3MP2A 4P16A 4IP3A 1UKFA 4MI7A 3PHXA 4IUMA 3OQCA 4ZTBA 5E6JA 4BOSA 3PHWA 3PRMA 3PRPA 3E9SA 1PVJA 3ZNHA 3BB7A 1YZBA 2AGAA 3MJ5A 4REZA 3TMPA 4BOUA 2JRIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DKI A;  4D8E A;  3BBA A;  3BB7 A;  4D8B A;  4D8I A;  4RKX A;  1PVJ A;  2UZJ A;  2JTC A; 
#chains in the Genus database with same CATH topology
 1KHP A;  3O0U A;  1ATK A;  2C0Y A;  2R9O A;  4I05 A;  3CH3 X;  4CDF B;  1YK8 A;  3KKU A;  3N3K A;  4RF1 A;  4BS5 A;  3W30 A;  2YJ8 A;  1PXV A;  1QMY A;  3HWN A;  1KFU L;  2DCA A;  2XU1 A;  2BTW B;  2G7Y A;  3F75 A;  4HWY A;  5CVM A;  1BQI A;  1ZIV A;  4D8E A;  3QJ3 A;  1MIR A;  1CSB B;  4D8B A;  1TL9 A;  4Q8G A;  3ZUA A;  3TRK A;  1MDW A;  2G8E A;  1MEM A;  4RNA A;  2FUD A;  3P5W A;  4CDC B;  3WXE A;  3IHP A;  4P6G A;  4OVZ A;  2XU5 A;  4WUR A;  2IPP B;  4KLB A;  1EF7 A;  3MTV A;  3QT4 A;  3S3Q A;  4HXD B;  3PSE A;  1ITO A;  2P7U A;  1Y08 A;  3KSE A;  3WXF A;  1AYV A;  1GCB A;  4W5C A;  4AXL A;  2BDL A;  5JA7 A;  3E1Z B;  4PT5 A;  3P5X A;  2VHF A;  2G8J A;  1CPJ A;  4MI7 A;  2Y6E A;  4BOS A;  1BP4 A;  2HXZ A;  3KFQ A;  2FRQ A;  4K7C A;  4YV8 A;  9PAP A;  2E01 A;  4FIP A;  4N79 A;  2B1M A;  5CVO B;  3PBH A;  1VJV A;  3BC3 A;  2AUZ A;  4P6E A;  2AU1 A;  3BPM A;  3P5V A;  1ZCM A;  1KHQ A;  3HD3 A;  3WXG A;  3RNV A;  4DMX A;  5EGW A;  2JTC A;  2DZY A;  2FTD A;  7PCK A;  3IUT A;  1EWL A;  3V6E A;  2AIM A;  1GHH A;  3BBA A;  1CTE A;  3V6C A;  1HUC B;  1QDQ A;  1TLO A;  1NB3 A;  1PIP A;  2R6N A;  3U8E A;  5F02 A;  1YK7 A;  1PPD A;  2NQG A;  2DOS A;  2DJF B;  1NLJ A;  3D6S A;  1QOL A;  2AYN A;  3P5U A;  3BOW A;  2ACT A;  3GCB A;  5JH3 A;  4RY2 A;  4I07 A;  3CBK A;  4X6J A;  1QXP A;  3KWB X;  2Z84 A;  2YJ9 A;  3OVZ A;  2FRA A;  5PAD A;  3PHU A;  2IBI A;  4YYU A;  4OW0 A;  3H8B A;  3DF0 A;  2PNS A;  4R3D A;  5EF4 A;  3K24 A;  2PRE A;  3USV A;  2E03 A;  2NQD B;  2YJC A;  3B21 A;  2HHN A;  1PBH A;  3QSD A;  2HH5 A;  2HWK A;  1NB5 A;  3C0R A;  2DC7 A;  1PE6 A;  4DMY A;  2AVW A;  1MHW A;  4X6H A;  3OQC A;  4ZTB A;  1BY8 A;  1AIM A;  2DCD A;  4QH6 A;  3PRM A;  4YYR A;  1PPO A;  4KQT A;  1SG2 A;  3E9S A;  1PVJ A;  1U2M A;  1FH0 A;  1DF0 A;  4W4U A;  4FJC A;  4XR7 A;  3ZNH A;  4CDE B;  1F2C A;  3IEJ A;  1VSN A;  1YZB A;  3OIS A;  2NQI A;  2BDZ A;  2AGA A;  3BCN A;  2R9F A;  4BOU A;  1U5I A;  1ICF A;  2FQ9 A;  1U9Q X;  2DCB A;  1U9W A;  4BOZ A;  4GUA A;  4PP1 A;  4OVZ B;  4D8I A;  3OVX A;  4RKX A;  2H7J A;  6PAD A;  1MEG A;  4MZO A;  5KO3 A;  1NPZ A;  2OP3 A;  4WA6 A;  4AXM A;  1THE A;  3BWK A;  2R9N A;  4MSX A;  2BU3 A;  2G6D A;  2DZZ A;  2DC6 A;  2O6X A;  5J94 A;  3M99 A;  4Q8H A;  2YJB A;  1JQP A;  3B79 A;  3H8C A;  2P86 A;  3IFU A;  3MOR A;  3IMA A;  1Q6K A;  2CIO A;  1KFX L;  1A6R A;  3I06 A;  2E02 A;  1AYW A;  1PPP A;  1POP A;  3BY4 A;  1U9V A;  1F2B A;  1EWO A;  3NHE A;  3MHS A;  5EZQ A;  2BTW A;  2HD5 A;  2WBF X;  2DC9 A;  2JQG R;  5K16 A;  2R9C A;  1CJL A;  3LFY A;  1SP4 B;  1GMY A;  3LXS A;  1CS8 A;  1EWP A;  5A24 A;  3K8U A;  3MTN A;  2CB5 A;  3MP2 A;  4P16 A;  4IP3 A;  4YYS A;  1EWM A;  1CVZ A;  1UKF A;  1IWD A;  5E6J A;  3MHH A;  1PAD A;  3KWZ A;  2OUL A;  3PHW A;  2P0R A;  4BS6 A;  3C9E A;  3KX1 A;  2AUX A;  4QBB A;  4YYQ A;  3ERV A;  1PPN A;  1CB5 A;  3H6S A;  3N3G A;  3CBJ A;  2PAD A;  3BB7 A;  3PW3 A;  1O0E A;  4G54 A;  4N4Z A;  3MJ5 A;  4REZ A;  2DJG B;  3OF9 A;  3S3R A;  1DEU A;  2XU3 A;  3HHA A;  5CVN B;  4W5B A;  2AS8 A;  1CV8 A;  1ME3 A;  4FK5 A;  4I04 A;  4CZW A;  2FE8 A;  4XUI A;  4PI3 A;  1XKG A;  3H7D A;  4QRG A;  3CH2 X;  2R9M A;  1M6D A;  3O1G A;  3AI8 A;  3W31 A;  5FPW A;  4OEM A;  1X9Y A;  2JQF R;  1SNK A;  3PT2 A;  2ATO A;  4CDD B;  1BGO A;  1AYU A;  2ARY A;  4BPV A;  1TU6 A;  2B1N A;  2OZ2 A;  3PNR A;  2J7Q A;  3N4C A;  4BOQ A;  3TNX A;  4RF0 A;  1AU4 A;  4YYV A;  4YVA A;  2FYE A;  4PP2 E;  1MS6 A;  4OEL A;  2F1G A;  1Y4H A;  2NQA A;  1AU0 A;  3RVX A;  3O65 A;  2YJ2 A;  4MZS A;  4QRV A;  4M0W A;  3H89 A;  5EZS A;  1PCI A;  5JZE A;  1GEC E;  4QRX A;  2DC8 A;  3F5V A;  3K9M A;  4X6I A;  4MM3 B;  2DCC A;  4A5U A;  1AEC A;  2UZJ A;  3HHI A;  3OF8 A;  4BOP A;  2E00 A;  4YYW A;  3I3T A;  4N8W A;  8PCH A;  1F2A A;  1GLO A;  2J7Q C;  4XZX A;  1CQD A;  1DKI A;  2AYO A;  1S4V A;  2FT2 A;  1U9X A;  1K3B B;  1AU3 A;  3IV2 A;  3PDF A;  3PHX A;  4IUM A;  2VHS A;  1NL6 A;  5CHT A;  2Y5B A;  4ZUX U;  1F29 A;  3BPF A;  2GFO A;  4PAD A;  2FO5 A;  3PRP A;  2F7D A;  4BSQ A;  1YAL A;  3IOQ A;  1YT7 A;  5CHV A;  2XU4 A;  4BQV A;  1NQC A;  1KXR A;  3RVW A;  2PBH A;  3RVV A;  1YVB A;  1AU2 A;  3KW9 A;  1ME4 A;  3TMP A;  1STF E;  4EVX A;  2GHU A;  2JRI A; 
#chains in the Genus database with same CATH homology
 4BOZ A;  3RNV A;  4GUA A;  4OVZ B;  4D8I A;  4RKX A;  2FE8 A;  4RF1 A;  2JTC A;  3W30 A;  5KO3 A;  2BTW B;  3BBA A;  2BU3 A;  3W31 A;  4D8E A;  3PT2 A;  4D8B A;  3TRK A;  2DOS A;  3IFU A;  2J7Q A;  4BOQ A;  4RF0 A;  4RNA A;  3BY4 A;  4OVZ A;  3O65 A;  2Z84 A;  4M0W A;  5EZS A;  4WUR A;  5JZE A;  5EZQ A;  3PHU A;  2BTW A;  3MTV A;  4OW0 A;  4HXD B;  3PSE A;  4MM3 B;  4R3D A;  4A5U A;  2UZJ A;  4BOP A;  3B21 A;  2HWK A;  4XZX A;  2J7Q C;  4EVX A;  3C0R A;  4PT5 A;  1DKI A;  3MP2 A;  4P16 A;  4IP3 A;  1UKF A;  4MI7 A;  3PHX A;  4IUM A;  3OQC A;  4ZTB A;  5E6J A;  4BOS A;  3PHW A;  3PRM A;  3PRP A;  3E9S A;  1PVJ A;  3ZNH A;  3BB7 A;  1YZB A;  2AGA A;  3MJ5 A;  4REZ A;  3TMP A;  4BOU A;  2JRI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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