1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
molecule keywords pyrogenic exotoxin B
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
1PVJA 4D8BA 4D8IA 3BB7A 1DKIA 2JTCA 3BBAA 4RKXA 4D8EA 2UZJA
chains in the Genus database with same CATH superfamily
3RNVA 4WURA 1ITOA 4DMYA 3RVWA 1TL9A 4YYQA 1Q6KA 1YZBA 4Q8GA 3KWZA 3P5UA 3QSDA 2AUXA 1MEGA 2DCAA 2JQGR 4GUAA 3OQCA 1PVJA 3OVZA 3BCNA 1K3BB 2YJ8A 2P0RA 3IMAA 2YJBA 1NPZA 1M6DA 2XU4A 4BOPA 3KFQA 2XU5A 5JA7A 3IFUA 3BOWA 2BTWB 3F75A 3PHXA 1GHHA 4CDCB 1KHPA 2HWKA 2DC7A 3MJ5A 1U9WA 3BB7A 3P5XA 2NQDB 2CB5A 4FIPA 3CH2X 4PP1A 4XR7A 2YJ9A 4X6IA 2B1NA 4BQVA 3WXEA 3KW9A 1AU3A 3W31A 3PRMA 2BDZA 1SG2A 1DF0A 2F7DA 2NQAA 1YK8A 3ZNHA 1KFXL 1GECE 2GHUA 2E01A 5JH3A 2R6NA 5EF4A 3B79A 5EZSA 1GMYA 3H8CA 1EF7A 5PADA 2VHSA 5A24A 3V6CA 4BOUA 2JTCA 1VSNA 2AUZA 3BY4A 4YYRA 4RF1A 4P6EA 3WXGA 1SP4B 1JQPA 2PADA 2FRQA 2G7YA 3QJ3A 1VJVA 1CVZA 2FYEA 4MZSA 2ACTA 2YJCA 3O65A 1Y4HA 1PXVA 2R9MA 2AYOA 1U2MA 1QMYA 3PHUA 4QRVA 2C0YA 2R9OA 3PBHA 1QDQA 4W5BA 4BS6A 1HUCB 4G54A 1MS6A 3BWKA 4N79A 3V6EA 1PBHA 2R9FA 1U5IA 1ZIVA 3MTVA 3HWNA 3E1ZB 2WBFX 2DOSA 3KSEA 1TU6A 2AU1A 2DC9A 1NB5A 5EZQA 2PNSA 4AXMA 1ME4A 3P5WA 1U9QX 4WA6A 2DCCA 5JZEA 1YT7A 1CJLA 1STFE 3LFYA 3W30A 2FQ9A 3I06A 4XZXA 4BOSA 9PAPA 1PPOA 4OEMA 3IHPA 4OW0A 1KXRA 1AU4A 3C9EA 1MHWA 1EWOA 4P16A 2B1MA 4RY2A 3KKUA 2XU1A 3PHWA 3OISA 5FPWA 3H89A 3IUTA 4CDEB 1U9XA 4D8IA 1EWMA 1BGOA 3CBJA 3F5VA 1PPPA 3GCBA 1YALA 2GFOA 4I05A 3PSEA 1CTEA 3M99A 1NLJA 4BPVA 1F29A 2FT2A 1EWLA 4R3DA 4A5UA 2E00A 4DMXA 4M0WA 4HWYA 3MORA 4QRXA 4OELA 1BP4A 4ZTBA 2JRIA 1PPNA 2YJ2A 2Y5BA 3BC3A 2FO5A 2IPPB 3HHIA 4KLBA 3BBAA 2DJGB 2OULA 2BTWA 3NHEA 1KFUL 1XKGA 4BSQA 3N4CA 7PCKA 4PP2E 2ATOA 2DJFB 3O1GA 2AIMA 1F2CA 1NL6A 4FK5A 2ARYA 3MP2A 4HXDB 3TMPA 4MSXA 3PW3A 4QRGA 2FUDA 4MM3B 3D6SA 2FRAA 3C0RA 3PNRA 1NQCA 5EGWA 3MHSA 2XU3A 3USVA 3HD3A 1PIPA 5CHVA 4MI7A 4Q8HA 2AS8A 2P7UA 5KO3A 1IWDA 3B21A 1F2AA 3N3KA 3PRPA 1DKIA 1SNKA 2AGAA 1AU2A 2G8EA 2Z84A 4P6GA 4BOZA 2DZYA 2R9CA 1CSBB 2O6XA 4IP3A 3ERVA 1PCIA 3WXFA 4YYUA 1S4VA 2PREA 2UZJA 2HXZA 2JQFR 3ZUAA 4XUIA 3K8UA 3H6SA 4CDDB 3HHAA 4YV8A 4D8BA 1AYUA 4PADA 4PI3A 1CS8A 3BPFA 2Y6EA 4AXLA 1AYWA 4REZA 3S3RA 1ICFA 3OVXA 1MIRA 4I04A 2BU3A 1AIMA 4CZWA 2OP3A 2CIOA 1U9VA 4MZOA 3IOQA 2DC6A 1FH0A 1KHQA 2DCBA 3E9SA 1TLOA 1O0EA 2DCDA 1DEUA 1AU0A 1THEA 4KQTA 4BOQA 2FTDA 4FJCA 8PCHA 1CB5A 1BY8A 3I3TA 1GCBA 3PDFA 1QXPA 3OF8A 3IV2A 1AYVA 3QT4A 2H7JA 4CDFB 1ATKA 5CHTA 3MHHA 1QOLA 4QH6A 2BDLA 4RF0A 1BQIA 4I07A 1PPDA 1MDWA 3RVVA 1ME3A 3CBKA 3U8EA 1ZCMA 3TRKA 4YYSA 3LXSA 5E6JA 5K16A 1MEMA 2OZ2A 3AI8A 1YVBA 1CV8A 3H8BA 3BPMA 4IUMA 4RNAA 2HH5A 2E02A 6PADA 4YYWA 2IBIA 4PT5A 2DZZA 2P86A 3DF0A 2AVWA 3CH3X 1UKFA 2R9NA 3KWBX 3OF9A 4BS5A 2DC8A 4W4UA 5CVMA 1F2BA 3PT2A 5CVOB 4OVZB 4D8EA 3S3QA 3RVXA 2J7QC 3MTNA 4YVAA 1YK7A 3IEJA 2VHFA 1GLOA 1NB3A 1EWPA 3K9MA 4N4ZA 3P5VA 2F1GA 2E03A 2FE8A 2PBHA 3TNXA 4W5CA 3H7DA 2G8JA 1POPA 2HD5A 4ZUXU 1PADA 1A6RA 3O0UA 3K24A 1CQDA 4X6HA 4QBBA 5J94A 1CPJA 4OVZA 2J7QA 1X9YA 2AYNA 2NQGA 1PE6A 4EVXA 3KX1A 5F02A 2HHNA 4N8WA 4RKXA 1AECA 5CVNB 2NQIA 3N3GA 1Y08A 4YYVA 4K7CA 2G6DA 4X6JA
chains in the Genus database with same CATH topology
2J7QA 3RNVA 3PHUA 4WURA 4P16A 5EZQA 4IUMA 4MI7A 4RNAA 4EVXA 2BU3A 3ZNHA 3PHWA 5KO3A 2FE8A 3B21A 2HWKA 2JRIA 2UZJA 1YZBA 4RF0A 4PT5A 4ZTBA 5JZEA 3MJ5A 3MP2A 4HXDB 5EZSA 4D8IA 3PRPA 4OVZA 3BB7A 1DKIA 4RKXA 3TMPA 3W30A 3E9SA 1UKFA 4GUAA 2AGAA 3OQCA 2Z84A 4XZXA 4BOSA 3PSEA 1PVJA 4BOUA 4D8BA 3TRKA 4BOZA 3BBAA 2JTCA 4BOQA 3PT2A 2BTWA 3O65A 4MM3B 4OVZB 3BY4A 3C0RA 5E6JA 4D8EA 2J7QC 4OW0A 3MTVA 4IP3A 4R3DA 4A5UA 4BOPA 4M0WA 2DOSA 4REZA 4RF1A 3IFUA 3W31A 2BTWB 3PRMA 3PHXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PVJ A;  4D8B A;  4D8I A;  3BB7 A;  1DKI A;  2JTC A;  3BBA A;  4RKX A;  4D8E A;  2UZJ A; 
#chains in the Genus database with same CATH topology
 3RNV A;  4WUR A;  1ITO A;  4DMY A;  3RVW A;  1TL9 A;  4YYQ A;  1Q6K A;  1YZB A;  4Q8G A;  3KWZ A;  3P5U A;  3QSD A;  2AUX A;  1MEG A;  2DCA A;  2JQG R;  4GUA A;  3OQC A;  1PVJ A;  3OVZ A;  3BCN A;  1K3B B;  2YJ8 A;  2P0R A;  3IMA A;  2YJB A;  1NPZ A;  1M6D A;  2XU4 A;  4BOP A;  3KFQ A;  2XU5 A;  5JA7 A;  3IFU A;  3BOW A;  2BTW B;  3F75 A;  3PHX A;  1GHH A;  4CDC B;  1KHP A;  2HWK A;  2DC7 A;  3MJ5 A;  1U9W A;  3BB7 A;  3P5X A;  2NQD B;  2CB5 A;  4FIP A;  3CH2 X;  4PP1 A;  4XR7 A;  2YJ9 A;  4X6I A;  2B1N A;  4BQV A;  3WXE A;  3KW9 A;  1AU3 A;  3W31 A;  3PRM A;  2BDZ A;  1SG2 A;  1DF0 A;  2F7D A;  2NQA A;  1YK8 A;  3ZNH A;  1KFX L;  1GEC E;  2GHU A;  2E01 A;  5JH3 A;  2R6N A;  5EF4 A;  3B79 A;  5EZS A;  1GMY A;  3H8C A;  1EF7 A;  5PAD A;  2VHS A;  5A24 A;  3V6C A;  4BOU A;  2JTC A;  1VSN A;  2AUZ A;  3BY4 A;  4YYR A;  4RF1 A;  4P6E A;  3WXG A;  1SP4 B;  1JQP A;  2PAD A;  2FRQ A;  2G7Y A;  3QJ3 A;  1VJV A;  1CVZ A;  2FYE A;  4MZS A;  2ACT A;  2YJC A;  3O65 A;  1Y4H A;  1PXV A;  2R9M A;  2AYO A;  1U2M A;  1QMY A;  3PHU A;  4QRV A;  2C0Y A;  2R9O A;  3PBH A;  1QDQ A;  4W5B A;  4BS6 A;  1HUC B;  4G54 A;  1MS6 A;  3BWK A;  4N79 A;  3V6E A;  1PBH A;  2R9F A;  1U5I A;  1ZIV A;  3MTV A;  3HWN A;  3E1Z B;  2WBF X;  2DOS A;  3KSE A;  1TU6 A;  2AU1 A;  2DC9 A;  1NB5 A;  5EZQ A;  2PNS A;  4AXM A;  1ME4 A;  3P5W A;  1U9Q X;  4WA6 A;  2DCC A;  5JZE A;  1YT7 A;  1CJL A;  1STF E;  3LFY A;  3W30 A;  2FQ9 A;  3I06 A;  4XZX A;  4BOS A;  9PAP A;  1PPO A;  4OEM A;  3IHP A;  4OW0 A;  1KXR A;  1AU4 A;  3C9E A;  1MHW A;  1EWO A;  4P16 A;  2B1M A;  4RY2 A;  3KKU A;  2XU1 A;  3PHW A;  3OIS A;  5FPW A;  3H89 A;  3IUT A;  4CDE B;  1U9X A;  4D8I A;  1EWM A;  1BGO A;  3CBJ A;  3F5V A;  1PPP A;  3GCB A;  1YAL A;  2GFO A;  4I05 A;  3PSE A;  1CTE A;  3M99 A;  1NLJ A;  4BPV A;  1F29 A;  2FT2 A;  1EWL A;  4R3D A;  4A5U A;  2E00 A;  4DMX A;  4M0W A;  4HWY A;  3MOR A;  4QRX A;  4OEL A;  1BP4 A;  4ZTB A;  2JRI A;  1PPN A;  2YJ2 A;  2Y5B A;  3BC3 A;  2FO5 A;  2IPP B;  3HHI A;  4KLB A;  3BBA A;  2DJG B;  2OUL A;  2BTW A;  3NHE A;  1KFU L;  1XKG A;  4BSQ A;  3N4C A;  7PCK A;  4PP2 E;  2ATO A;  2DJF B;  3O1G A;  2AIM A;  1F2C A;  1NL6 A;  4FK5 A;  2ARY A;  3MP2 A;  4HXD B;  3TMP A;  4MSX A;  3PW3 A;  4QRG A;  2FUD A;  4MM3 B;  3D6S A;  2FRA A;  3C0R A;  3PNR A;  1NQC A;  5EGW A;  3MHS A;  2XU3 A;  3USV A;  3HD3 A;  1PIP A;  5CHV A;  4MI7 A;  4Q8H A;  2AS8 A;  2P7U A;  5KO3 A;  1IWD A;  3B21 A;  1F2A A;  3N3K A;  3PRP A;  1DKI A;  1SNK A;  2AGA A;  1AU2 A;  2G8E A;  2Z84 A;  4P6G A;  4BOZ A;  2DZY A;  2R9C A;  1CSB B;  2O6X A;  4IP3 A;  3ERV A;  1PCI A;  3WXF A;  4YYU A;  1S4V A;  2PRE A;  2UZJ A;  2HXZ A;  2JQF R;  3ZUA A;  4XUI A;  3K8U A;  3H6S A;  4CDD B;  3HHA A;  4YV8 A;  4D8B A;  1AYU A;  4PAD A;  4PI3 A;  1CS8 A;  3BPF A;  2Y6E A;  4AXL A;  1AYW A;  4REZ A;  3S3R A;  1ICF A;  3OVX A;  1MIR A;  4I04 A;  2BU3 A;  1AIM A;  4CZW A;  2OP3 A;  2CIO A;  1U9V A;  4MZO A;  3IOQ A;  2DC6 A;  1FH0 A;  1KHQ A;  2DCB A;  3E9S A;  1TLO A;  1O0E A;  2DCD A;  1DEU A;  1AU0 A;  1THE A;  4KQT A;  4BOQ A;  2FTD A;  4FJC A;  8PCH A;  1CB5 A;  1BY8 A;  3I3T A;  1GCB A;  3PDF A;  1QXP A;  3OF8 A;  3IV2 A;  1AYV A;  3QT4 A;  2H7J A;  4CDF B;  1ATK A;  5CHT A;  3MHH A;  1QOL A;  4QH6 A;  2BDL A;  4RF0 A;  1BQI A;  4I07 A;  1PPD A;  1MDW A;  3RVV A;  1ME3 A;  3CBK A;  3U8E A;  1ZCM A;  3TRK A;  4YYS A;  3LXS A;  5E6J A;  5K16 A;  1MEM A;  2OZ2 A;  3AI8 A;  1YVB A;  1CV8 A;  3H8B A;  3BPM A;  4IUM A;  4RNA A;  2HH5 A;  2E02 A;  6PAD A;  4YYW A;  2IBI A;  4PT5 A;  2DZZ A;  2P86 A;  3DF0 A;  2AVW A;  3CH3 X;  1UKF A;  2R9N A;  3KWB X;  3OF9 A;  4BS5 A;  2DC8 A;  4W4U A;  5CVM A;  1F2B A;  3PT2 A;  5CVO B;  4OVZ B;  4D8E A;  3S3Q A;  3RVX A;  2J7Q C;  3MTN A;  4YVA A;  1YK7 A;  3IEJ A;  2VHF A;  1GLO A;  1NB3 A;  1EWP A;  3K9M A;  4N4Z A;  3P5V A;  2F1G A;  2E03 A;  2FE8 A;  2PBH A;  3TNX A;  4W5C A;  3H7D A;  2G8J A;  1POP A;  2HD5 A;  4ZUX U;  1PAD A;  1A6R A;  3O0U A;  3K24 A;  1CQD A;  4X6H A;  4QBB A;  5J94 A;  1CPJ A;  4OVZ A;  2J7Q A;  1X9Y A;  2AYN A;  2NQG A;  1PE6 A;  4EVX A;  3KX1 A;  5F02 A;  2HHN A;  4N8W A;  4RKX A;  1AEC A;  5CVN B;  2NQI A;  3N3G A;  1Y08 A;  4YYV A;  4K7C A;  2G6D A;  4X6J A; 
#chains in the Genus database with same CATH homology
 2J7Q A;  3RNV A;  3PHU A;  4WUR A;  4P16 A;  5EZQ A;  4IUM A;  4MI7 A;  4RNA A;  4EVX A;  2BU3 A;  3ZNH A;  3PHW A;  5KO3 A;  2FE8 A;  3B21 A;  2HWK A;  2JRI A;  2UZJ A;  1YZB A;  4RF0 A;  4PT5 A;  4ZTB A;  5JZE A;  3MJ5 A;  3MP2 A;  4HXD B;  5EZS A;  4D8I A;  3PRP A;  4OVZ A;  3BB7 A;  1DKI A;  4RKX A;  3TMP A;  3W30 A;  3E9S A;  1UKF A;  4GUA A;  2AGA A;  3OQC A;  2Z84 A;  4XZX A;  4BOS A;  3PSE A;  1PVJ A;  4BOU A;  4D8B A;  3TRK A;  4BOZ A;  3BBA A;  2JTC A;  4BOQ A;  3PT2 A;  2BTW A;  3O65 A;  4MM3 B;  4OVZ B;  3BY4 A;  3C0R A;  5E6J A;  4D8E A;  2J7Q C;  4OW0 A;  3MTV A;  4IP3 A;  4R3D A;  4A5U A;  4BOP A;  4M0W A;  2DOS A;  4REZ A;  4RF1 A;  3IFU A;  3W31 A;  2BTW B;  3PRM A;  3PHX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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