1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
molecule keywords pyrogenic exotoxin B
publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
4D8IA 2UZJA 2JTCA 3BBAA 4D8EA 4D8BA 4RKXA 1DKIA 3BB7A 1PVJA
chains in the Genus database with same CATH superfamily
4G54A 3BC3A 3B21A 2ATOA 3OQCA 2NQDB 2E01A 4YVAA 4N4ZA 2HHNA 2HXZA 1AU3A 2AVWA 4OVZA 3E9SA 2CIOA 3QJ3A 5EZQA 2AS8A 3W30A 1A6RA 1NB5A 1YK8A 1PXVA 4BQVA 2JRIA 3KSEA 5EF4A 3LXSA 3P5WA 3H6SA 1NQCA 3H89A 4D8BA 1GECE 1XKGA 4M0WA 5CVMA 3QT4A 1NL6A 2R9MA 3S3QA 2DCAA 2J7QA 3W31A 1NPZA 4BSQA 4QH6A 3HWNA 1KFUL 2YJ9A 3LFYA 2P86A 4I05A 3O65A 2DZZA 2R9OA 4I07A 3MP2A 1ITOA 2DC7A 2G6DA 3MJ5A 2DJFB 3D6SA 4N79A 4BOPA 3USVA 3PHUA 1DF0A 4ZTBA 2HWKA 4KLBA 4N8WA 1NLJA 2J7QC 3S3RA 1SG2A 2DZYA 4OELA 4MM3B 3RNVA 1GLOA 1UKFA 1AECA 3MHHA 4YYQA 3TNXA 1EWLA 1CSBB 4WA6A 2FQ9A 5CHVA 3MHSA 3OF8A 1GMYA 3F75A 2PADA 1EWPA 1GHHA 1YALA 2AUXA 4I04A 4YYUA 2B1NA 2IPPB 1AU0A 1AYWA 1TL9A 3H7DA 3O0UA 2BU3A 1AYVA 4P16A 4REZA 3BPFA 1K3BB 1YZBA 3KW9A 3H8CA 2P7UA 3BCNA 2E00A 2FTDA 8PCHA 4QRXA 2E02A 4D8EA 4RF0A 2NQIA 5KO3A 1CV8A 4DMXA 3N3KA 1CPJA 2P0RA 1BP4A 2DC9A 2HD5A 4Q8GA 2JQFR 4YYRA 3KWZA 2PBHA 2E03A 3F5VA 3V6EA 1KHPA 1CB5A 5E6JA 3C0RA 3OF9A 1YVBA 4MZSA 1PBHA 2FUDA 2G7YA 2F1GA 1YK7A 2ACTA 4XZXA 3ZUAA 1QDQA 4MI7A 5CVOB 1F2AA 4RKXA 4KQTA 1FH0A 1PPOA 1EWMA 1PPNA 1VSNA 4OW0A 1QOLA 3I06A 2AYNA 3TMPA 1DEUA 3KFQA 2UZJA 2DCCA 2FRAA 3HHAA 3V6CA 1ATKA 2OZ2A 2BTWB 2OP3A 3P5UA 3RVXA 5JH3A 2PNSA 1IWDA 3MTVA 2AGAA 2DC6A 3RVWA 1THEA 4P6GA 2R9NA 3K24A 3PRPA 2DCDA 5K16A 4MZOA 1ICFA 1CS8A 5JA7A 1QXPA 1YT7A 2GFOA 4FIPA 1AIMA 3P5VA 3M99A 4BS5A 3OVXA 3PHWA 3WXGA 1AU2A 3BWKA 4PP2E 1U9QX 1TLOA 3PW3A 4W5CA 3CBKA 4W4UA 1MDWA 3WXFA 3HHIA 1AYUA 2XU4A 2H7JA 4BOSA 4BOUA 4BOZA 3GCBA 3KWBX 4YV8A 4BS6A 2CB5A 1MHWA 4BOQA 3I3TA 4YYSA 1M6DA 4PP1A 1PCIA 2C0YA 3WXEA 3BPMA 3KKUA 4PI3A 4RY2A 4QRVA 1F2CA 3MTNA 2FE8A 1BY8A 2DC8A 4CDFB 4K7CA 5F02A 4R3DA 3U8EA 1S4VA 4FK5A 4X6HA 2NQAA 3RVVA 2DJGB 3O1GA 3PSEA 1PVJA 4OEMA 1MIRA 2O6XA 4BPVA 2Y6EA 3AI8A 2FO5A 5EZSA 3PNRA 1U2MA 4MSXA 3DF0A 1MEGA 2Y5BA 1ZIVA 3BBAA 4X6JA 1F2BA 2FYEA 2GHUA 3E1ZB 2VHSA 3N3GA 1POPA 1STFE 2BTWA 2DCBA 2YJ8A 1U9XA 4W5BA 1Q6KA 2JQGR 1GCBA 3C9EA 6PADA 1CTEA 3PDFA 3PT2A 7PCKA 2XU5A 1KXRA 2R9FA 3ERVA 1SNKA 2XU3A 3CH2X 1KFXL 5A24A 1U9WA 4QBBA 2HH5A 1O0EA 4GUAA 3BY4A 5CHTA 2WBFX 1ME3A 1PE6A 2BDLA 4OVZB 3OISA 1KHQA 4YYWA 2G8EA 3K8UA 1TU6A 2R9CA 3IFUA 4FJCA 2AU1A 4EVXA 3MORA 4XUIA 3BB7A 2FT2A 4DMYA 2F7DA 3PBHA 1JQPA 2YJBA 4P6EA 5CVNB 5J94A 4CZWA 1Y08A 3QSDA 4HXDB 2R6NA 4D8IA 4PADA 1AU4A 1CVZA 4QRGA 1EWOA 2Z84A 1U5IA 4A5UA 2JTCA 4IUMA 3IHPA 3PRMA 4YYVA 3B79A 2PREA 1PADA 2VHFA 2NQGA 3OVZA 4PT5A 4IP3A 2FRQA 4HWYA 2AIMA 3IOQA 1QMYA 3BOWA 1MEMA 1MS6A 4ZUXU 3TRKA 2YJ2A 1BGOA 3HD3A 9PAPA 3IEJA 1SP4B 3IV2A 4CDDB 3N4CA 4AXMA 1VJVA 4Q8HA 1CQDA 1NB3A 1PPDA 4RNAA 4WURA 2OULA 1EF7A 5JZEA 1U9VA 4X6IA 5EGWA 3P5XA 3H8BA 1HUCB 2BDZA 4AXLA 3IMAA 3CBJA 2ARYA 1BQIA 5FPWA 1Y4HA 4CDEB 1DKIA 3K9MA 5PADA 1X9YA 3KX1A 1ME4A 4XR7A 3PHXA 1F29A 1ZCMA 1PIPA 2AUZA 2XU1A 4CDCB 1CJLA 3NHEA 3IUTA 1PPPA 2DOSA 3CH3X 2B1MA 3ZNHA 2G8JA 4RF1A 2AYOA 2IBIA 2YJCA
chains in the Genus database with same CATH topology
3IFUA 3B21A 3OQCA 4EVXA 3BB7A 4D8EA 4RF0A 5KO3A 4OVZA 3E9SA 4BOQA 5EZQA 4HXDB 3W30A 4D8IA 5E6JA 3C0RA 2Z84A 2JRIA 4A5UA 2JTCA 4IUMA 3PRMA 2FE8A 4D8BA 4M0WA 4XZXA 4MI7A 2J7QA 4R3DA 3W31A 4PT5A 4RKXA 4IP3A 3O65A 3MP2A 3MJ5A 3PSEA 1PVJA 3TRKA 4OW0A 3TMPA 4BOPA 3PHUA 5EZSA 4ZTBA 2UZJA 2HWKA 2J7QC 4RNAA 4WURA 2BTWB 3BBAA 5JZEA 4MM3B 3RNVA 1UKFA 3MTVA 2AGAA 2BTWA 1DKIA 3PRPA 3PHXA 3PT2A 3PHWA 2BU3A 4P16A 2DOSA 4GUAA 4REZA 3ZNHA 3BY4A 1YZBA 4RF1A 4OVZB 4BOSA 4BOUA 4BOZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  2UZJ A;  2JTC A;  3BBA A;  4D8E A;  4D8B A;  4RKX A;  1DKI A;  3BB7 A;  1PVJ A; 
#chains in the Genus database with same CATH topology
 4G54 A;  3BC3 A;  3B21 A;  2ATO A;  3OQC A;  2NQD B;  2E01 A;  4YVA A;  4N4Z A;  2HHN A;  2HXZ A;  1AU3 A;  2AVW A;  4OVZ A;  3E9S A;  2CIO A;  3QJ3 A;  5EZQ A;  2AS8 A;  3W30 A;  1A6R A;  1NB5 A;  1YK8 A;  1PXV A;  4BQV A;  2JRI A;  3KSE A;  5EF4 A;  3LXS A;  3P5W A;  3H6S A;  1NQC A;  3H89 A;  4D8B A;  1GEC E;  1XKG A;  4M0W A;  5CVM A;  3QT4 A;  1NL6 A;  2R9M A;  3S3Q A;  2DCA A;  2J7Q A;  3W31 A;  1NPZ A;  4BSQ A;  4QH6 A;  3HWN A;  1KFU L;  2YJ9 A;  3LFY A;  2P86 A;  4I05 A;  3O65 A;  2DZZ A;  2R9O A;  4I07 A;  3MP2 A;  1ITO A;  2DC7 A;  2G6D A;  3MJ5 A;  2DJF B;  3D6S A;  4N79 A;  4BOP A;  3USV A;  3PHU A;  1DF0 A;  4ZTB A;  2HWK A;  4KLB A;  4N8W A;  1NLJ A;  2J7Q C;  3S3R A;  1SG2 A;  2DZY A;  4OEL A;  4MM3 B;  3RNV A;  1GLO A;  1UKF A;  1AEC A;  3MHH A;  4YYQ A;  3TNX A;  1EWL A;  1CSB B;  4WA6 A;  2FQ9 A;  5CHV A;  3MHS A;  3OF8 A;  1GMY A;  3F75 A;  2PAD A;  1EWP A;  1GHH A;  1YAL A;  2AUX A;  4I04 A;  4YYU A;  2B1N A;  2IPP B;  1AU0 A;  1AYW A;  1TL9 A;  3H7D A;  3O0U A;  2BU3 A;  1AYV A;  4P16 A;  4REZ A;  3BPF A;  1K3B B;  1YZB A;  3KW9 A;  3H8C A;  2P7U A;  3BCN A;  2E00 A;  2FTD A;  8PCH A;  4QRX A;  2E02 A;  4D8E A;  4RF0 A;  2NQI A;  5KO3 A;  1CV8 A;  4DMX A;  3N3K A;  1CPJ A;  2P0R A;  1BP4 A;  2DC9 A;  2HD5 A;  4Q8G A;  2JQF R;  4YYR A;  3KWZ A;  2PBH A;  2E03 A;  3F5V A;  3V6E A;  1KHP A;  1CB5 A;  5E6J A;  3C0R A;  3OF9 A;  1YVB A;  4MZS A;  1PBH A;  2FUD A;  2G7Y A;  2F1G A;  1YK7 A;  2ACT A;  4XZX A;  3ZUA A;  1QDQ A;  4MI7 A;  5CVO B;  1F2A A;  4RKX A;  4KQT A;  1FH0 A;  1PPO A;  1EWM A;  1PPN A;  1VSN A;  4OW0 A;  1QOL A;  3I06 A;  2AYN A;  3TMP A;  1DEU A;  3KFQ A;  2UZJ A;  2DCC A;  2FRA A;  3HHA A;  3V6C A;  1ATK A;  2OZ2 A;  2BTW B;  2OP3 A;  3P5U A;  3RVX A;  5JH3 A;  2PNS A;  1IWD A;  3MTV A;  2AGA A;  2DC6 A;  3RVW A;  1THE A;  4P6G A;  2R9N A;  3K24 A;  3PRP A;  2DCD A;  5K16 A;  4MZO A;  1ICF A;  1CS8 A;  5JA7 A;  1QXP A;  1YT7 A;  2GFO A;  4FIP A;  1AIM A;  3P5V A;  3M99 A;  4BS5 A;  3OVX A;  3PHW A;  3WXG A;  1AU2 A;  3BWK A;  4PP2 E;  1U9Q X;  1TLO A;  3PW3 A;  4W5C A;  3CBK A;  4W4U A;  1MDW A;  3WXF A;  3HHI A;  1AYU A;  2XU4 A;  2H7J A;  4BOS A;  4BOU A;  4BOZ A;  3GCB A;  3KWB X;  4YV8 A;  4BS6 A;  2CB5 A;  1MHW A;  4BOQ A;  3I3T A;  4YYS A;  1M6D A;  4PP1 A;  1PCI A;  2C0Y A;  3WXE A;  3BPM A;  3KKU A;  4PI3 A;  4RY2 A;  4QRV A;  1F2C A;  3MTN A;  2FE8 A;  1BY8 A;  2DC8 A;  4CDF B;  4K7C A;  5F02 A;  4R3D A;  3U8E A;  1S4V A;  4FK5 A;  4X6H A;  2NQA A;  3RVV A;  2DJG B;  3O1G A;  3PSE A;  1PVJ A;  4OEM A;  1MIR A;  2O6X A;  4BPV A;  2Y6E A;  3AI8 A;  2FO5 A;  5EZS A;  3PNR A;  1U2M A;  4MSX A;  3DF0 A;  1MEG A;  2Y5B A;  1ZIV A;  3BBA A;  4X6J A;  1F2B A;  2FYE A;  2GHU A;  3E1Z B;  2VHS A;  3N3G A;  1POP A;  1STF E;  2BTW A;  2DCB A;  2YJ8 A;  1U9X A;  4W5B A;  1Q6K A;  2JQG R;  1GCB A;  3C9E A;  6PAD A;  1CTE A;  3PDF A;  3PT2 A;  7PCK A;  2XU5 A;  1KXR A;  2R9F A;  3ERV A;  1SNK A;  2XU3 A;  3CH2 X;  1KFX L;  5A24 A;  1U9W A;  4QBB A;  2HH5 A;  1O0E A;  4GUA A;  3BY4 A;  5CHT A;  2WBF X;  1ME3 A;  1PE6 A;  2BDL A;  4OVZ B;  3OIS A;  1KHQ A;  4YYW A;  2G8E A;  3K8U A;  1TU6 A;  2R9C A;  3IFU A;  4FJC A;  2AU1 A;  4EVX A;  3MOR A;  4XUI A;  3BB7 A;  2FT2 A;  4DMY A;  2F7D A;  3PBH A;  1JQP A;  2YJB A;  4P6E A;  5CVN B;  5J94 A;  4CZW A;  1Y08 A;  3QSD A;  4HXD B;  2R6N A;  4D8I A;  4PAD A;  1AU4 A;  1CVZ A;  4QRG A;  1EWO A;  2Z84 A;  1U5I A;  4A5U A;  2JTC A;  4IUM A;  3IHP A;  3PRM A;  4YYV A;  3B79 A;  2PRE A;  1PAD A;  2VHF A;  2NQG A;  3OVZ A;  4PT5 A;  4IP3 A;  2FRQ A;  4HWY A;  2AIM A;  3IOQ A;  1QMY A;  3BOW A;  1MEM A;  1MS6 A;  4ZUX U;  3TRK A;  2YJ2 A;  1BGO A;  3HD3 A;  9PAP A;  3IEJ A;  1SP4 B;  3IV2 A;  4CDD B;  3N4C A;  4AXM A;  1VJV A;  4Q8H A;  1CQD A;  1NB3 A;  1PPD A;  4RNA A;  4WUR A;  2OUL A;  1EF7 A;  5JZE A;  1U9V A;  4X6I A;  5EGW A;  3P5X A;  3H8B A;  1HUC B;  2BDZ A;  4AXL A;  3IMA A;  3CBJ A;  2ARY A;  1BQI A;  5FPW A;  1Y4H A;  4CDE B;  1DKI A;  3K9M A;  5PAD A;  1X9Y A;  3KX1 A;  1ME4 A;  4XR7 A;  3PHX A;  1F29 A;  1ZCM A;  1PIP A;  2AUZ A;  2XU1 A;  4CDC B;  1CJL A;  3NHE A;  3IUT A;  1PPP A;  2DOS A;  3CH3 X;  2B1M A;  3ZNH A;  2G8J A;  4RF1 A;  2AYO A;  2IBI A;  2YJC A; 
#chains in the Genus database with same CATH homology
 3IFU A;  3B21 A;  3OQC A;  4EVX A;  3BB7 A;  4D8E A;  4RF0 A;  5KO3 A;  4OVZ A;  3E9S A;  4BOQ A;  5EZQ A;  4HXD B;  3W30 A;  4D8I A;  5E6J A;  3C0R A;  2Z84 A;  2JRI A;  4A5U A;  2JTC A;  4IUM A;  3PRM A;  2FE8 A;  4D8B A;  4M0W A;  4XZX A;  4MI7 A;  2J7Q A;  4R3D A;  3W31 A;  4PT5 A;  4RKX A;  4IP3 A;  3O65 A;  3MP2 A;  3MJ5 A;  3PSE A;  1PVJ A;  3TRK A;  4OW0 A;  3TMP A;  4BOP A;  3PHU A;  5EZS A;  4ZTB A;  2UZJ A;  2HWK A;  2J7Q C;  4RNA A;  4WUR A;  2BTW B;  3BBA A;  5JZE A;  4MM3 B;  3RNV A;  1UKF A;  3MTV A;  2AGA A;  2BTW A;  1DKI A;  3PRP A;  3PHX A;  3PT2 A;  3PHW A;  2BU3 A;  4P16 A;  2DOS A;  4GUA A;  4REZ A;  3ZNH A;  3BY4 A;  1YZB A;  4RF1 A;  4OVZ B;  4BOS A;  4BOU A;  4BOZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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