1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
molecule keywords pyrogenic exotoxin B
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
4D8IA 4D8EA 1DKIA 3BBAA 2UZJA 3BB7A 2JTCA 1PVJA 4D8BA 4RKXA
chains in the Genus database with same CATH superfamily
2ARYA 4DMYA 1QDQA 2P86A 3MHHA 2R9MA 4HWYA 4CDDB 4Q8GA 3U8EA 4YVAA 1ICFA 2YJ2A 4N8WA 2NQAA 1CVZA 4XR7A 4QRXA 6PADA 4R3DA 3BCNA 1PPOA 4MZOA 1AU3A 1DF0A 2FUDA 2GFOA 4YYUA 5KO3A 2R9NA 3H6SA 1AU2A 4XZXA 1TL9A 2FE8A 4K7CA 3BPFA 4WURA 1MIRA 3MORA 2J7QA 2JTCA 3IUTA 4YYSA 4IUMA 4XUIA 2DCDA 1PPPA 1EWPA 4RF0A 3MP2A 2AVWA 5CHTA 2R9CA 3E9SA 2OULA 1MHWA 3N3GA 1CV8A 1EF7A 3P5WA 1AECA 3MHSA 2AUXA 4GUAA 3O0UA 1U5IA 1SNKA 1U9WA 2DCCA 3KKUA 2Y6EA 4X6IA 3KWZA 3HHIA 4D8IA 5CVNB 1DKIA 2CIOA 3BB7A 2IBIA 1NB3A 2AYNA 4RF1A 4BQVA 3PBHA 2E00A 3P5XA 1HUCB 3RVVA 2OP3A 3ERVA 1AU0A 3BOWA 3B21A 2R9FA 2FT2A 1VSNA 4IP3A 4WA6A 3PRPA 2J7QC 2DCAA 1YK7A 3LXSA 4OEMA 4REZA 2FTDA 3KSEA 3HWNA 2HHNA 2DZYA 3W31A 4EVXA 1EWLA 3V6CA 4P16A 3IOQA 4MI7A 2F7DA 4BPVA 1YALA 2P7UA 7PCKA 3HHAA 4OW0A 8PCHA 1MEGA 1CS8A 2PADA 3S3RA 4ZUXU 4KQTA 4YYVA 3OISA 1QXPA 1ZIVA 4KLBA 4BOZA 1BY8A 4W4UA 2AUZA 3I3TA 1SP4B 1NB5A 3H89A 3I06A 5F02A 2YJCA 3OVZA 1AIMA 1YVBA 2FQ9A 3QT4A 3S3QA 3W30A 4AXLA 2DJFB 3ZUAA 3RVWA 5EGWA 3DF0A 2DJGB 4P6GA 3P5VA 4P6EA 2HXZA 4BOPA 1UKFA 3IV2A 3NHEA 1PPNA 3ZNHA 1GHHA 2FYEA 2JRIA 2YJ8A 1F2BA 4BOUA 1CB5A 4BSQA 4QRGA 4PADA 2WBFX 3V6EA 2H7JA 2BTWA 1X9YA 4OVZB 4N4ZA 4CDEB 2G7YA 1ME3A 4RKXA 3PHUA 2G8JA 4X6JA 4YV8A 3P5UA 2E01A 2R6NA 3CH3X 4X6HA 3IHPA 3LFYA 5JZEA 3RNVA 1XKGA 1KFXL 3KX1A 1Y08A 2JQFR 4G54A 1PE6A 5JH3A 1ME4A 1YK8A 3RVXA 4BOSA 2XU1A 2PNSA 1IWDA 3PRMA 3C9EA 1U2MA 2BTWB 2B1MA 2F1GA 4W5CA 1S4VA 2O6XA 2B1NA 1KFUL 1EWOA 3H7DA 3BBAA 3WXEA 1Y4HA 3O65A 4N79A 2P0RA 2BU3A 4BS6A 3BWKA 4YYRA 1PBHA 1F29A 2G8EA 4MSXA 4OELA 4I04A 2HD5A 1PCIA 3H8BA 3PDFA 2ATOA 2Y5BA 2FRAA 4DMXA 2GHUA 3KWBX 3QJ3A 2FRQA 3O1GA 4YYQA 1K3BB 1MEMA 5E6JA 1PPDA 3B79A 2AS8A 4YYWA 1THEA 3CBKA 4PT5A 1PIPA 3MTNA 3PT2A 2AU1A 3PHXA 1NQCA 3BY4A 3BPMA 1PADA 3CBJA 2PBHA 1SG2A 1ZCMA 3F5VA 3K9MA 1MDWA 4W5BA 3KFQA 5J94A 3KW9A 5CVMA 5JA7A 4OVZA 1NPZA 4A5UA 1F2AA 5PADA 5K16A 2E03A 3BC3A 2NQDB 5EZSA 3PSEA 3N4CA 1AU4A 3TRKA 1YT7A 2FO5A 2JQGR 2XU3A 1CSBB 4RY2A 2DCBA 1DEUA 2VHSA 1JQPA 5A24A 3PHWA 1GECE 4CDCB 1AYWA 2OZ2A 3CH2X 3MJ5A 2XU5A 4FIPA 1FH0A 4FJCA 3WXGA 1CPJA 1CTEA 1BQIA 1TU6A 4I07A 4D8EA 4PP2E 2DC8A 2VHFA 1KHPA 3F75A 2R9OA 2AYOA 1M6DA 2Z84A 3M99A 1BGOA 4AXMA 2IPPB 1QOLA 1CQDA 4PI3A 5CVOB 3K8UA 1NLJA 1QMYA 1U9QX 4QRVA 1PVJA 3TNXA 3WXFA 1KXRA 2YJ9A 1Q6KA 2NQIA 3USVA 2G6DA 4MM3B 3OVXA 3H8CA 1GMYA 1TLOA 3IMAA 3IFUA 1BP4A 4QH6A 2UZJA 4QBBA 4I05A 2HH5A 3HD3A 1GCBA 5FPWA 3GCBA 2YJBA 1KHQA 1GLOA 1MS6A 2C0YA 3OF8A 3IEJA 3OQCA 2BDLA 2XU4A 3TMPA 1ITOA 2DZZA 5EZQA 1YZBA 1PXVA 3C0RA 1O0EA 4CDFB 4RNAA 2BDZA 1U9VA 2AGAA 4HXDB 3QSDA 3AI8A 1ATKA 1A6RA 1U9XA 4M0WA 2AIMA 2DC9A 3PNRA 2ACTA 4BS5A 1F2CA 3N3KA 4PP1A 1CJLA 4MZSA 4Q8HA 2CB5A 2E02A 3E1ZB 1AYVA 1POPA 1VJVA 3PW3A 5EF4A 5CHVA 3MTVA 4ZTBA 4D8BA 3OF9A 2DC6A 3D6SA 1STFE 2DOSA 4FK5A 2DC7A 2HWKA 1EWMA 4BOQA 3K24A 2NQGA 1AYUA 2PREA 9PAPA 1NL6A 4CZWA
chains in the Genus database with same CATH topology
3PT2A 3PHXA 4GUAA 4D8EA 3BY4A 4IP3A 3W30A 3PRPA 2J7QC 2J7QA 3OQCA 2JTCA 4OW0A 3TMPA 5JZEA 3RNVA 4MM3B 5EZQA 1YZBA 4D8IA 1DKIA 3C0RA 4IUMA 3MTVA 3BBAA 4ZTBA 3BB7A 2Z84A 4OVZA 4REZA 2BTWA 4RNAA 2AGAA 4HXDB 4OVZB 4D8BA 4BOZA 3IFUA 4R3DA 4M0WA 3MP2A 4RF0A 3PHWA 4BOSA 2DOSA 4RF1A 4A5UA 2UZJA 2HWKA 3O65A 4EVXA 1UKFA 3W31A 5E6JA 3MJ5A 4BOPA 4BOQA 4P16A 4RKXA 3E9SA 2BU3A 3PHUA 3ZNHA 5KO3A 2JRIA 3PRMA 4XZXA 3PSEA 5EZSA 4MI7A 2FE8A 4PT5A 3TRKA 1PVJA 2BTWB 4WURA 4BOUA 3B21A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  4D8E A;  1DKI A;  3BBA A;  2UZJ A;  3BB7 A;  2JTC A;  1PVJ A;  4D8B A;  4RKX A; 
#chains in the Genus database with same CATH topology
 2ARY A;  4DMY A;  1QDQ A;  2P86 A;  3MHH A;  2R9M A;  4HWY A;  4CDD B;  4Q8G A;  3U8E A;  4YVA A;  1ICF A;  2YJ2 A;  4N8W A;  2NQA A;  1CVZ A;  4XR7 A;  4QRX A;  6PAD A;  4R3D A;  3BCN A;  1PPO A;  4MZO A;  1AU3 A;  1DF0 A;  2FUD A;  2GFO A;  4YYU A;  5KO3 A;  2R9N A;  3H6S A;  1AU2 A;  4XZX A;  1TL9 A;  2FE8 A;  4K7C A;  3BPF A;  4WUR A;  1MIR A;  3MOR A;  2J7Q A;  2JTC A;  3IUT A;  4YYS A;  4IUM A;  4XUI A;  2DCD A;  1PPP A;  1EWP A;  4RF0 A;  3MP2 A;  2AVW A;  5CHT A;  2R9C A;  3E9S A;  2OUL A;  1MHW A;  3N3G A;  1CV8 A;  1EF7 A;  3P5W A;  1AEC A;  3MHS A;  2AUX A;  4GUA A;  3O0U A;  1U5I A;  1SNK A;  1U9W A;  2DCC A;  3KKU A;  2Y6E A;  4X6I A;  3KWZ A;  3HHI A;  4D8I A;  5CVN B;  1DKI A;  2CIO A;  3BB7 A;  2IBI A;  1NB3 A;  2AYN A;  4RF1 A;  4BQV A;  3PBH A;  2E00 A;  3P5X A;  1HUC B;  3RVV A;  2OP3 A;  3ERV A;  1AU0 A;  3BOW A;  3B21 A;  2R9F A;  2FT2 A;  1VSN A;  4IP3 A;  4WA6 A;  3PRP A;  2J7Q C;  2DCA A;  1YK7 A;  3LXS A;  4OEM A;  4REZ A;  2FTD A;  3KSE A;  3HWN A;  2HHN A;  2DZY A;  3W31 A;  4EVX A;  1EWL A;  3V6C A;  4P16 A;  3IOQ A;  4MI7 A;  2F7D A;  4BPV A;  1YAL A;  2P7U A;  7PCK A;  3HHA A;  4OW0 A;  8PCH A;  1MEG A;  1CS8 A;  2PAD A;  3S3R A;  4ZUX U;  4KQT A;  4YYV A;  3OIS A;  1QXP A;  1ZIV A;  4KLB A;  4BOZ A;  1BY8 A;  4W4U A;  2AUZ A;  3I3T A;  1SP4 B;  1NB5 A;  3H89 A;  3I06 A;  5F02 A;  2YJC A;  3OVZ A;  1AIM A;  1YVB A;  2FQ9 A;  3QT4 A;  3S3Q A;  3W30 A;  4AXL A;  2DJF B;  3ZUA A;  3RVW A;  5EGW A;  3DF0 A;  2DJG B;  4P6G A;  3P5V A;  4P6E A;  2HXZ A;  4BOP A;  1UKF A;  3IV2 A;  3NHE A;  1PPN A;  3ZNH A;  1GHH A;  2FYE A;  2JRI A;  2YJ8 A;  1F2B A;  4BOU A;  1CB5 A;  4BSQ A;  4QRG A;  4PAD A;  2WBF X;  3V6E A;  2H7J A;  2BTW A;  1X9Y A;  4OVZ B;  4N4Z A;  4CDE B;  2G7Y A;  1ME3 A;  4RKX A;  3PHU A;  2G8J A;  4X6J A;  4YV8 A;  3P5U A;  2E01 A;  2R6N A;  3CH3 X;  4X6H A;  3IHP A;  3LFY A;  5JZE A;  3RNV A;  1XKG A;  1KFX L;  3KX1 A;  1Y08 A;  2JQF R;  4G54 A;  1PE6 A;  5JH3 A;  1ME4 A;  1YK8 A;  3RVX A;  4BOS A;  2XU1 A;  2PNS A;  1IWD A;  3PRM A;  3C9E A;  1U2M A;  2BTW B;  2B1M A;  2F1G A;  4W5C A;  1S4V A;  2O6X A;  2B1N A;  1KFU L;  1EWO A;  3H7D A;  3BBA A;  3WXE A;  1Y4H A;  3O65 A;  4N79 A;  2P0R A;  2BU3 A;  4BS6 A;  3BWK A;  4YYR A;  1PBH A;  1F29 A;  2G8E A;  4MSX A;  4OEL A;  4I04 A;  2HD5 A;  1PCI A;  3H8B A;  3PDF A;  2ATO A;  2Y5B A;  2FRA A;  4DMX A;  2GHU A;  3KWB X;  3QJ3 A;  2FRQ A;  3O1G A;  4YYQ A;  1K3B B;  1MEM A;  5E6J A;  1PPD A;  3B79 A;  2AS8 A;  4YYW A;  1THE A;  3CBK A;  4PT5 A;  1PIP A;  3MTN A;  3PT2 A;  2AU1 A;  3PHX A;  1NQC A;  3BY4 A;  3BPM A;  1PAD A;  3CBJ A;  2PBH A;  1SG2 A;  1ZCM A;  3F5V A;  3K9M A;  1MDW A;  4W5B A;  3KFQ A;  5J94 A;  3KW9 A;  5CVM A;  5JA7 A;  4OVZ A;  1NPZ A;  4A5U A;  1F2A A;  5PAD A;  5K16 A;  2E03 A;  3BC3 A;  2NQD B;  5EZS A;  3PSE A;  3N4C A;  1AU4 A;  3TRK A;  1YT7 A;  2FO5 A;  2JQG R;  2XU3 A;  1CSB B;  4RY2 A;  2DCB A;  1DEU A;  2VHS A;  1JQP A;  5A24 A;  3PHW A;  1GEC E;  4CDC B;  1AYW A;  2OZ2 A;  3CH2 X;  3MJ5 A;  2XU5 A;  4FIP A;  1FH0 A;  4FJC A;  3WXG A;  1CPJ A;  1CTE A;  1BQI A;  1TU6 A;  4I07 A;  4D8E A;  4PP2 E;  2DC8 A;  2VHF A;  1KHP A;  3F75 A;  2R9O A;  2AYO A;  1M6D A;  2Z84 A;  3M99 A;  1BGO A;  4AXM A;  2IPP B;  1QOL A;  1CQD A;  4PI3 A;  5CVO B;  3K8U A;  1NLJ A;  1QMY A;  1U9Q X;  4QRV A;  1PVJ A;  3TNX A;  3WXF A;  1KXR A;  2YJ9 A;  1Q6K A;  2NQI A;  3USV A;  2G6D A;  4MM3 B;  3OVX A;  3H8C A;  1GMY A;  1TLO A;  3IMA A;  3IFU A;  1BP4 A;  4QH6 A;  2UZJ A;  4QBB A;  4I05 A;  2HH5 A;  3HD3 A;  1GCB A;  5FPW A;  3GCB A;  2YJB A;  1KHQ A;  1GLO A;  1MS6 A;  2C0Y A;  3OF8 A;  3IEJ A;  3OQC A;  2BDL A;  2XU4 A;  3TMP A;  1ITO A;  2DZZ A;  5EZQ A;  1YZB A;  1PXV A;  3C0R A;  1O0E A;  4CDF B;  4RNA A;  2BDZ A;  1U9V A;  2AGA A;  4HXD B;  3QSD A;  3AI8 A;  1ATK A;  1A6R A;  1U9X A;  4M0W A;  2AIM A;  2DC9 A;  3PNR A;  2ACT A;  4BS5 A;  1F2C A;  3N3K A;  4PP1 A;  1CJL A;  4MZS A;  4Q8H A;  2CB5 A;  2E02 A;  3E1Z B;  1AYV A;  1POP A;  1VJV A;  3PW3 A;  5EF4 A;  5CHV A;  3MTV A;  4ZTB A;  4D8B A;  3OF9 A;  2DC6 A;  3D6S A;  1STF E;  2DOS A;  4FK5 A;  2DC7 A;  2HWK A;  1EWM A;  4BOQ A;  3K24 A;  2NQG A;  1AYU A;  2PRE A;  9PAP A;  1NL6 A;  4CZW A; 
#chains in the Genus database with same CATH homology
 3PT2 A;  3PHX A;  4GUA A;  4D8E A;  3BY4 A;  4IP3 A;  3W30 A;  3PRP A;  2J7Q C;  2J7Q A;  3OQC A;  2JTC A;  4OW0 A;  3TMP A;  5JZE A;  3RNV A;  4MM3 B;  5EZQ A;  1YZB A;  4D8I A;  1DKI A;  3C0R A;  4IUM A;  3MTV A;  3BBA A;  4ZTB A;  3BB7 A;  2Z84 A;  4OVZ A;  4REZ A;  2BTW A;  4RNA A;  2AGA A;  4HXD B;  4OVZ B;  4D8B A;  4BOZ A;  3IFU A;  4R3D A;  4M0W A;  3MP2 A;  4RF0 A;  3PHW A;  4BOS A;  2DOS A;  4RF1 A;  4A5U A;  2UZJ A;  2HWK A;  3O65 A;  4EVX A;  1UKF A;  3W31 A;  5E6J A;  3MJ5 A;  4BOP A;  4BOQ A;  4P16 A;  4RKX A;  3E9S A;  2BU3 A;  3PHU A;  3ZNH A;  5KO3 A;  2JRI A;  3PRM A;  4XZX A;  3PSE A;  5EZS A;  4MI7 A;  2FE8 A;  4PT5 A;  3TRK A;  1PVJ A;  2BTW B;  4WUR A;  4BOU A;  3B21 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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