1DKIA

Crystal structure of the zymogen form of streptococcal pyrogenic exotoxin b active site (c47s) mutant
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
335
structure length
303
Chain Sequence
LDKVNLGGELSGSNMYVYNGFVIVSGDKRSPEILGYSTSGSFDVNGKENIASFMESYVEQIKENKKLPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGSVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Toxin
molecule keywords PYROGENIC EXOTOXIN B ZYMOGEN
total genus 70
structure length 303
sequence length 335
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 1999-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1dkiA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1dkiA01
4D8EA 4RKXA 3BBAA 3BB7A 2UZJA 1DKIA 4D8IA 1PVJA 2JTCA 4D8BA
chains in the Genus database with same CATH superfamily
2FRQA 3RNVA 2NQDB 4RF0A 1U5IA 1STFE 2R9FA 4CDDB 3IOQA 1BP4A 3OF9A 4K7CA 4YYSA 2XU1A 1YVBA 1GMYA 1EWPA 3BPFA 1TLOA 3P5VA 1TL9A 1U9VA 1PPPA 2UZJA 3E9SA 4OW0A 1XKGA 2E00A 2B1MA 2DC7A 2VHFA 1MEMA 2P0RA 2ARYA 1YZBA 1DKIA 4IUMA 2WBFX 3PHUA 3TRKA 1MS6A 1Q6KA 3P5UA 1THEA 2CIOA 4RKXA 3MHHA 2PNSA 1GECE 4WA6A 4W5BA 1KHPA 3S3RA 1HUCB 4X6IA 2AUXA 2H7JA 4EVXA 2FRAA 2DC8A 1BGOA 1ZCMA 4YYUA 3BC3A 2G8EA 3IUTA 3PBHA 4PP2E 5EZQA 1MDWA 1DF0A 2FT2A 1AU4A 4HWYA 3D6SA 1MHWA 3HWNA 3KWBX 3PHXA 1GCBA 1JQPA 2G6DA 4CDCB 2DOSA 2AYNA 1F29A 2DJFB 2GFOA 2GHUA 1AU2A 3B79A 4OVZB 3BY4A 2XU5A 3BWKA 4PT5A 1NB3A 3H6SA 1ME3A 2DZZA 1S4VA 2DCDA 2PBHA 2YJBA 4XUIA 3V6EA 5E6JA 3LFYA 4OVZA 2BTWB 4KLBA 5FPWA 4BPVA 1Y4HA 3PW3A 3BB7A 4PP1A 3IEJA 3F5VA 1NL6A 3B21A 3K8UA 3WXEA 3OF8A 4CZWA 4BOZA 4ZUXU 4Q8HA 1PE6A 1YK7A 2IBIA 1SG2A 1QOLA 4DMXA 2DC9A 1ATKA 2BDZA 3H89A 4CDFB 2DC6A 3E1ZB 4DMYA 3IV2A 3LXSA 2YJ9A 2P86A 2R9OA 2OZ2A 1K3BB 3MTVA 4BOSA 5F02A 2B1NA 2PREA 3PT2A 1EWMA 3P5WA 1MEGA 3OISA 2Z84A 3HD3A 3OVXA 2JTCA 2NQIA 2JRIA 3PNRA 1U2MA 4D8EA 1AU0A 3ZNHA 2YJ2A 2DCBA 4RY2A 2BDLA 4Q8GA 2HHNA 2XU3A 3O65A 3P5XA 3QJ3A 3KSEA 1QMYA 2HD5A 4X6JA 4FJCA 4P6EA 5EF4A 3K24A 2E01A 5PADA 3KX1A 4BOUA 9PAPA 5JZEA 4GUAA 2DZYA 2CB5A 3NHEA 1QDQA 4R3DA 3N3KA 1GHHA 1X9YA 3KWZA 2FTDA 3RVWA 1ITOA 2OULA 5EGWA 1PCIA 4I04A 1NPZA 3OQCA 3DF0A 3CH3X 5J94A 2HWKA 5EZSA 3USVA 3IFUA 2AYOA 1TU6A 2Y6EA 2AGAA 4YYRA 4ZTBA 5JH3A 3ERVA 3PDFA 4AXLA 1CS8A 5JA7A 2BTWA 4N4ZA 1BQIA 3MP2A 1KFUL 2G8JA 4MM3B 1DEUA 1UKFA 1NQCA 1QXPA 4XZXA 3S3QA 1VSNA 1EWOA 3M99A 1PXVA 3QT4A 3MJ5A 4BQVA 3BBAA 4BOQA 2PADA 2AUZA 4QRXA 1PADA 1Y08A 2E03A 3BCNA 3H7DA 3OVZA 4X6HA 4D8BA 2HXZA 3MTNA 4FIPA 4KQTA 1VJVA 4OEMA 4BS6A 3F75A 2IPPB 2R9CA 1U9XA 5KO3A 3WXFA 3BPMA 1A6RA 1NLJA 1CTEA 2FE8A 3CBJA 2R6NA 1ICFA 4YVAA 2AU1A 3RVVA 5CVNB 1PPOA 2NQGA 1MIRA 5CVOB 3O1GA 2AS8A 1ME4A 2JQGR 4P6GA 3BOWA 1KXRA 4BOPA 2FUDA 8PCHA 1YALA 1YT7A 3I3TA 4W4UA 4CDEB 4REZA 1F2CA 2AIMA 3KKUA 4QH6A 1AIMA 1FH0A 1PPDA 4QBBA 3CBKA 4MI7A 5A24A 3PRPA 2J7QC 1CQDA 3TNXA 1GLOA 4MSXA 5CHVA 3PHWA 4N79A 3HHAA 3PRMA 2J7QA 1M6DA 1YK8A 2F1GA 4YYWA 1F2BA 1EWLA 4G54A 6PADA 4MZOA 4M0WA 2ACTA 3QSDA 4P16A 4I07A 4OELA 1KHQA 5CHTA 4D8IA 2DCCA 4BSQA 3MORA 2G7YA 2DJGB 2F7DA 3C0RA 2DCAA 4HXDB 3KW9A 4W5CA 7PCKA 2YJCA 1BY8A 5CVMA 4BS5A 1AYVA 3IMAA 2O6XA 1O0EA 4QRVA 4YYVA 4RNAA 2Y5BA 3N3GA 3RVXA 3IHPA 3V6CA 4FK5A 4I05A 3TMPA 1AYUA 2VHSA 3O0UA 4AXMA 4QRGA 2C0YA 4N8WA 2JQFR 4RF1A 3W31A 1CB5A 4IP3A 4A5UA 4XR7A 2R9NA 1KFXL 4PI3A 3MHSA 2BU3A 1SP4B 3HHIA 3U8EA 1CV8A 3W30A 3GCBA 1PBHA 1CVZA 4MZSA 1ZIVA 4YV8A 5K16A 2FQ9A 4PADA 1CPJA 2FYEA 1AYWA 1PVJA 1U9QX 3N4CA 3H8CA 2AVWA 4WURA 2P7UA 3WXGA 4YYQA 3PSEA 1AU3A 1PPNA 2ATOA 2NQAA 1PIPA 1SNKA 3H8BA 3AI8A 2XU4A 1POPA 1AECA 2R9MA 3K9MA 3I06A 2FO5A 1U9WA 3C9EA 1CSBB 1CJLA 2HH5A 2OP3A 1EF7A 3CH2X 3ZUAA 1NB5A 2YJ8A 3KFQA 1IWDA 2E02A 1F2AA
chains in the Genus database with same CATH topology
4RKXA 3PRMA 4MM3B 2Z84A 2J7QA 1UKFA 2UZJA 3E9SA 2BU3A 3RNVA 3OQCA 4OW0A 4RF0A 5EZQA 4BOPA 2JTCA 4XZXA 2HWKA 5KO3A 2JRIA 5E6JA 5EZSA 4RNAA 3IFUA 4D8EA 4OVZA 3W30A 4REZA 2BTWB 4BOUA 2FE8A 3ZNHA 5JZEA 4M0WA 4P16A 3MJ5A 2AGAA 3PHXA 4GUAA 3TMPA 4ZTBA 1YZBA 3BB7A 3BBAA 3MTVA 1DKIA 2DOSA 4IUMA 4MI7A 1PVJA 3PHUA 4BOSA 4BOQA 4D8IA 4IP3A 3B21A 3TRKA 3C0RA 4EVXA 3O65A 3PRPA 4OVZB 3BY4A 4R3DA 4D8BA 4RF1A 2BTWA 4HXDB 2J7QC 3PT2A 3MP2A 4WURA 3W31A 3PSEA 4PT5A 4BOZA 3PHWA 4A5UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8E A;  4RKX A;  3BBA A;  3BB7 A;  2UZJ A;  1DKI A;  4D8I A;  1PVJ A;  2JTC A;  4D8B A; 
#chains in the Genus database with same CATH topology
 2FRQ A;  3RNV A;  2NQD B;  4RF0 A;  1U5I A;  1STF E;  2R9F A;  4CDD B;  3IOQ A;  1BP4 A;  3OF9 A;  4K7C A;  4YYS A;  2XU1 A;  1YVB A;  1GMY A;  1EWP A;  3BPF A;  1TLO A;  3P5V A;  1TL9 A;  1U9V A;  1PPP A;  2UZJ A;  3E9S A;  4OW0 A;  1XKG A;  2E00 A;  2B1M A;  2DC7 A;  2VHF A;  1MEM A;  2P0R A;  2ARY A;  1YZB A;  1DKI A;  4IUM A;  2WBF X;  3PHU A;  3TRK A;  1MS6 A;  1Q6K A;  3P5U A;  1THE A;  2CIO A;  4RKX A;  3MHH A;  2PNS A;  1GEC E;  4WA6 A;  4W5B A;  1KHP A;  3S3R A;  1HUC B;  4X6I A;  2AUX A;  2H7J A;  4EVX A;  2FRA A;  2DC8 A;  1BGO A;  1ZCM A;  4YYU A;  3BC3 A;  2G8E A;  3IUT A;  3PBH A;  4PP2 E;  5EZQ A;  1MDW A;  1DF0 A;  2FT2 A;  1AU4 A;  4HWY A;  3D6S A;  1MHW A;  3HWN A;  3KWB X;  3PHX A;  1GCB A;  1JQP A;  2G6D A;  4CDC B;  2DOS A;  2AYN A;  1F29 A;  2DJF B;  2GFO A;  2GHU A;  1AU2 A;  3B79 A;  4OVZ B;  3BY4 A;  2XU5 A;  3BWK A;  4PT5 A;  1NB3 A;  3H6S A;  1ME3 A;  2DZZ A;  1S4V A;  2DCD A;  2PBH A;  2YJB A;  4XUI A;  3V6E A;  5E6J A;  3LFY A;  4OVZ A;  2BTW B;  4KLB A;  5FPW A;  4BPV A;  1Y4H A;  3PW3 A;  3BB7 A;  4PP1 A;  3IEJ A;  3F5V A;  1NL6 A;  3B21 A;  3K8U A;  3WXE A;  3OF8 A;  4CZW A;  4BOZ A;  4ZUX U;  4Q8H A;  1PE6 A;  1YK7 A;  2IBI A;  1SG2 A;  1QOL A;  4DMX A;  2DC9 A;  1ATK A;  2BDZ A;  3H89 A;  4CDF B;  2DC6 A;  3E1Z B;  4DMY A;  3IV2 A;  3LXS A;  2YJ9 A;  2P86 A;  2R9O A;  2OZ2 A;  1K3B B;  3MTV A;  4BOS A;  5F02 A;  2B1N A;  2PRE A;  3PT2 A;  1EWM A;  3P5W A;  1MEG A;  3OIS A;  2Z84 A;  3HD3 A;  3OVX A;  2JTC A;  2NQI A;  2JRI A;  3PNR A;  1U2M A;  4D8E A;  1AU0 A;  3ZNH A;  2YJ2 A;  2DCB A;  4RY2 A;  2BDL A;  4Q8G A;  2HHN A;  2XU3 A;  3O65 A;  3P5X A;  3QJ3 A;  3KSE A;  1QMY A;  2HD5 A;  4X6J A;  4FJC A;  4P6E A;  5EF4 A;  3K24 A;  2E01 A;  5PAD A;  3KX1 A;  4BOU A;  9PAP A;  5JZE A;  4GUA A;  2DZY A;  2CB5 A;  3NHE A;  1QDQ A;  4R3D A;  3N3K A;  1GHH A;  1X9Y A;  3KWZ A;  2FTD A;  3RVW A;  1ITO A;  2OUL A;  5EGW A;  1PCI A;  4I04 A;  1NPZ A;  3OQC A;  3DF0 A;  3CH3 X;  5J94 A;  2HWK A;  5EZS A;  3USV A;  3IFU A;  2AYO A;  1TU6 A;  2Y6E A;  2AGA A;  4YYR A;  4ZTB A;  5JH3 A;  3ERV A;  3PDF A;  4AXL A;  1CS8 A;  5JA7 A;  2BTW A;  4N4Z A;  1BQI A;  3MP2 A;  1KFU L;  2G8J A;  4MM3 B;  1DEU A;  1UKF A;  1NQC A;  1QXP A;  4XZX A;  3S3Q A;  1VSN A;  1EWO A;  3M99 A;  1PXV A;  3QT4 A;  3MJ5 A;  4BQV A;  3BBA A;  4BOQ A;  2PAD A;  2AUZ A;  4QRX A;  1PAD A;  1Y08 A;  2E03 A;  3BCN A;  3H7D A;  3OVZ A;  4X6H A;  4D8B A;  2HXZ A;  3MTN A;  4FIP A;  4KQT A;  1VJV A;  4OEM A;  4BS6 A;  3F75 A;  2IPP B;  2R9C A;  1U9X A;  5KO3 A;  3WXF A;  3BPM A;  1A6R A;  1NLJ A;  1CTE A;  2FE8 A;  3CBJ A;  2R6N A;  1ICF A;  4YVA A;  2AU1 A;  3RVV A;  5CVN B;  1PPO A;  2NQG A;  1MIR A;  5CVO B;  3O1G A;  2AS8 A;  1ME4 A;  2JQG R;  4P6G A;  3BOW A;  1KXR A;  4BOP A;  2FUD A;  8PCH A;  1YAL A;  1YT7 A;  3I3T A;  4W4U A;  4CDE B;  4REZ A;  1F2C A;  2AIM A;  3KKU A;  4QH6 A;  1AIM A;  1FH0 A;  1PPD A;  4QBB A;  3CBK A;  4MI7 A;  5A24 A;  3PRP A;  2J7Q C;  1CQD A;  3TNX A;  1GLO A;  4MSX A;  5CHV A;  3PHW A;  4N79 A;  3HHA A;  3PRM A;  2J7Q A;  1M6D A;  1YK8 A;  2F1G A;  4YYW A;  1F2B A;  1EWL A;  4G54 A;  6PAD A;  4MZO A;  4M0W A;  2ACT A;  3QSD A;  4P16 A;  4I07 A;  4OEL A;  1KHQ A;  5CHT A;  4D8I A;  2DCC A;  4BSQ A;  3MOR A;  2G7Y A;  2DJG B;  2F7D A;  3C0R A;  2DCA A;  4HXD B;  3KW9 A;  4W5C A;  7PCK A;  2YJC A;  1BY8 A;  5CVM A;  4BS5 A;  1AYV A;  3IMA A;  2O6X A;  1O0E A;  4QRV A;  4YYV A;  4RNA A;  2Y5B A;  3N3G A;  3RVX A;  3IHP A;  3V6C A;  4FK5 A;  4I05 A;  3TMP A;  1AYU A;  2VHS A;  3O0U A;  4AXM A;  4QRG A;  2C0Y A;  4N8W A;  2JQF R;  4RF1 A;  3W31 A;  1CB5 A;  4IP3 A;  4A5U A;  4XR7 A;  2R9N A;  1KFX L;  4PI3 A;  3MHS A;  2BU3 A;  1SP4 B;  3HHI A;  3U8E A;  1CV8 A;  3W30 A;  3GCB A;  1PBH A;  1CVZ A;  4MZS A;  1ZIV A;  4YV8 A;  5K16 A;  2FQ9 A;  4PAD A;  1CPJ A;  2FYE A;  1AYW A;  1PVJ A;  1U9Q X;  3N4C A;  3H8C A;  2AVW A;  4WUR A;  2P7U A;  3WXG A;  4YYQ A;  3PSE A;  1AU3 A;  1PPN A;  2ATO A;  2NQA A;  1PIP A;  1SNK A;  3H8B A;  3AI8 A;  2XU4 A;  1POP A;  1AEC A;  2R9M A;  3K9M A;  3I06 A;  2FO5 A;  1U9W A;  3C9E A;  1CSB B;  1CJL A;  2HH5 A;  2OP3 A;  1EF7 A;  3CH2 X;  3ZUA A;  1NB5 A;  2YJ8 A;  3KFQ A;  1IWD A;  2E02 A;  1F2A A; 
#chains in the Genus database with same CATH homology
 4RKX A;  3PRM A;  4MM3 B;  2Z84 A;  2J7Q A;  1UKF A;  2UZJ A;  3E9S A;  2BU3 A;  3RNV A;  3OQC A;  4OW0 A;  4RF0 A;  5EZQ A;  4BOP A;  2JTC A;  4XZX A;  2HWK A;  5KO3 A;  2JRI A;  5E6J A;  5EZS A;  4RNA A;  3IFU A;  4D8E A;  4OVZ A;  3W30 A;  4REZ A;  2BTW B;  4BOU A;  2FE8 A;  3ZNH A;  5JZE A;  4M0W A;  4P16 A;  3MJ5 A;  2AGA A;  3PHX A;  4GUA A;  3TMP A;  4ZTB A;  1YZB A;  3BB7 A;  3BBA A;  3MTV A;  1DKI A;  2DOS A;  4IUM A;  4MI7 A;  1PVJ A;  3PHU A;  4BOS A;  4BOQ A;  4D8I A;  4IP3 A;  3B21 A;  3TRK A;  3C0R A;  4EVX A;  3O65 A;  3PRP A;  4OVZ B;  3BY4 A;  4R3D A;  4D8B A;  4RF1 A;  2BTW A;  4HXD B;  2J7Q C;  3PT2 A;  3MP2 A;  4WUR A;  3W31 A;  3PSE A;  4PT5 A;  4BOZ A;  3PHW A;  4A5U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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