2YJ2A

Cathepsin l with a nitrile inhibitor
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
220
structure length
219
Chain Sequence
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTSDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords CATHEPSIN L1
publication title Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments.
pubmed doi rcsb
source organism Homo sapiens
total genus 72
structure length 219
sequence length 220
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2011-05-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 2yj2A00
2XU4A 2AVWA 3U8EA 2C0YA 4FK5A 3K8UA 3OF8A 2G7YA 1GECE 3IHPA 3K24A 3USVA 2AIMA 3WXGA 1EF7A 2ATOA 1X9YA 3BWKA 1ATKA 1U9QX 4CZWA 4MSXA 1BQIA 3CBKA 2E02A 3CBJA 4Q8HA 1F2CA 2DC8A 1YALA 3LXSA 4BPVA 4YYWA 1F2AA 2DCAA 3TNXA 3KSEA 4X6JA 4I05A 9PAPA 5J94A 3QJ3A 2G6DA 5EGWA 3KFQA 4PP2E 4G54A 1PPNA 3H6SA 3V6EA 3KWBX 1SNKA 2F7DA 2DJGB 1PPDA 1CSBB 1SP4B 3C9EA 4HWYA 1AU3A 4FJCA 2P86A 1A6RA 2YJ2A 1VJVA 3MHSA 3HHAA 2HD5A 2ARYA 3IMAA 3KW9A 1NB5A 2R9CA 2PBHA 3P5VA 2XU1A 1AYUA 4QH6A 4CDDB 1K3BB 3O1GA 4N79A 2JQFR 1TL9A 2HHNA 1CS8A 3M99A 2AUXA 1GLOA 1PBHA 1NLJA 1CPJA 1F2BA 1ITOA 3HWNA 5CVMA 2CB5A 2CIOA 5JH3A 2R9OA 2Y6EA 1DEUA 5CVOB 1PCIA 2O6XA 3CH3X 3N3GA 3ZUAA 3OVXA 2NQGA 1CJLA 4AXLA 2F1GA 2B1NA 3MORA 1MIRA 1MEGA 3P5XA 3OVZA 1NB3A 4CDEB 4P6EA 3IV2A 3K9MA 2E00A 2DCDA 4WA6A 2DC6A 5FPWA 2OZ2A 2PNSA 2ACTA 1ME3A 3I3TA 3PBHA 2E03A 3KX1A 3N3KA 5CVNB 1BP4A 3PW3A 3V6CA 4N8WA 3NHEA 1BY8A 2DJFB 4W4UA 4BQVA 3H7DA 1KHPA 4KLBA 1HUCB 1QXPA 1F29A 1XKGA 1CB5A 1CQDA 4CDFB 2E01A 2GFOA 2Y5BA 4MZOA 4YYSA 3I06A 3BOWA 3IOQA 4MZSA 2YJCA 1YK8A 6PADA 3E1ZB 2AYNA 1EWLA 4YYUA 1U9VA 4QRGA 1YK7A 2BDLA 2VHSA 1STFE 4CDCB 2PADA 1AECA 5CHTA 3B79A 2R9NA 4FIPA 1PPOA 2IBIA 1M6DA 1FH0A 1ZCMA 1TLOA 5PADA 3BPFA 2XU5A 2AU1A 2GHUA 1JQPA 3QT4A 5K16A 2R6NA 8PCHA 2DC9A 1U9WA 4I04A 1ZIVA 1EWOA 5CHVA 4PI3A 1KFUL 3WXFA 2YJ9A 2AS8A 4W5BA 2P7UA 4P6GA 3BCNA 1S4VA 4X6HA 2XU3A 2FRAA 2VHFA 5EF4A 3QSDA 3LFYA 1AU0A 2AUZA 3P5UA 4DMYA 4YYQA 3AI8A 1PE6A 4BS6A 4YV8A 1KHQA 2DCCA 3BC3A 3GCBA 1GCBA 1CV8A 1EWMA 3H8CA 1MS6A 1PXVA 3H89A 1AYWA 3CH2X 2FTDA 3PNRA 4QBBA 3H8BA 3P5WA 3S3RA 2DCBA 1GMYA 1PIPA 1AYVA 1QDQA 1KFXL 2NQDB 1O0EA 1PADA 2H7JA 2DZZA 2DC7A 1NPZA 3BPMA 4X6IA 1EWPA 2FQ9A 4BSQA 1CTEA 2DZYA 2FO5A 1YT7A 2NQIA 3F5VA 3RVXA 2JQGR 3KKUA 2OULA 3HHIA 1Q6KA 2AYOA 1NQCA 1VSNA 3F75A 4I07A 1U5IA 2FYEA 3KWZA 3O0UA 3D6SA 3OISA 1BGOA 2P0RA 4OEMA 1ICFA 2B1MA 4ZUXU 1ME4A 7PCKA 2PREA 2R9FA 1Y08A 4W5CA 3IEJA 1CVZA 1TU6A 4RY2A 4DMXA 1THEA 2BDZA 1NL6A 4QRVA 1IWDA 3ERVA 3N4CA 4Q8GA 2YJBA 1POPA 2FUDA 3PDFA 5F02A 5A24A 1MEMA 4XUIA 3WXEA 1DF0A 4YVAA 1AIMA 3MHHA 2FT2A 2OP3A 5JA7A 2HH5A 1MDWA 4BS5A 2NQAA 4PP1A 2G8EA 1PPPA 1AU4A 3HD3A 4YYVA 3RVVA 1AU2A 2YJ8A 2FRQA 3S3QA 4XR7A 2R9MA 4PADA 1U9XA 1MHWA 2G8JA 1QMYA 4OELA 2HXZA 4AXMA 1KXRA 1YVBA 4YYRA 3OF9A 1QOLA 3IUTA 4N4ZA 2IPPB 3RVWA 4QRXA 2WBFX 4K7CA 3DF0A 3MTNA 1Y4HA
chains in the Genus database with same CATH superfamily
2XU4A 2AVWA 3U8EA 3BY4A 2C0YA 1YZBA 4FK5A 4OW0A 3K8UA 3OF8A 2G7YA 1PVJA 1GECE 3IHPA 3K24A 3USVA 2AIMA 3WXGA 1EF7A 2ATOA 1X9YA 3BWKA 1ATKA 1U9QX 4ZTBA 4CZWA 4MSXA 1BQIA 3OQCA 3CBKA 2E02A 3CBJA 4Q8HA 1F2CA 2DC8A 1YALA 3ZNHA 3LXSA 4BPVA 4YYWA 1F2AA 2DCAA 3TNXA 3KSEA 4X6JA 4I05A 9PAPA 5J94A 3QJ3A 2G6DA 5EGWA 3KFQA 4PP2E 3E9SA 4G54A 1PPNA 3H6SA 3V6EA 4D8EA 3BB7A 3KWBX 4D8IA 1SNKA 2F7DA 2J7QC 2DJGB 1PPDA 4RKXA 3PHUA 1CSBB 1DKIA 1SP4B 3MP2A 3C9EA 4HWYA 1AU3A 4FJCA 2P86A 3RNVA 1A6RA 2YJ2A 1VJVA 3MHSA 3HHAA 2HD5A 2ARYA 3IMAA 3KW9A 4MM3B 1NB5A 4WURA 3W30A 2R9CA 2PBHA 3P5VA 2XU1A 1AYUA 4QH6A 4CDDB 1K3BB 3O1GA 4N79A 2JQFR 1TL9A 2HHNA 1CS8A 3M99A 2AUXA 1GLOA 1PBHA 5EZQA 1NLJA 3MTVA 1CPJA 1F2BA 1ITOA 3HWNA 5CVMA 2CB5A 2CIOA 3PHXA 5JH3A 2BTWB 2R9OA 2Y6EA 1DEUA 5CVOB 1PCIA 2O6XA 3CH3X 3MJ5A 3N3GA 3ZUAA 3OVXA 4R3DA 2NQGA 1CJLA 4AXLA 2F1GA 2B1NA 4A5UA 3MORA 1MIRA 1MEGA 3P5XA 3OVZA 2BTWA 1NB3A 4CDEB 4P6EA 3IV2A 3K9MA 2E00A 2DCDA 4WA6A 2DC6A 5FPWA 2OZ2A 2UZJA 2PNSA 2ACTA 3TRKA 1ME3A 3I3TA 3PBHA 2E03A 3KX1A 3N3KA 5CVNB 1BP4A 3PW3A 3V6CA 4N8WA 2FE8A 4REZA 3NHEA 1BY8A 2HWKA 3B21A 2DJFB 4W4UA 4BQVA 3H7DA 1KHPA 4KLBA 1HUCB 1QXPA 1F29A 4BOUA 1XKGA 1CB5A 1CQDA 4CDFB 2E01A 2GFOA 2Y5BA 4MZOA 4YYSA 3I06A 3BOWA 3IOQA 4MZSA 2YJCA 4OVZB 1YK8A 6PADA 3E1ZB 2AYNA 1EWLA 4YYUA 1U9VA 4QRGA 1YK7A 2BDLA 3PT2A 2VHSA 1STFE 4CDCB 2PADA 1AECA 5CHTA 3B79A 2R9NA 4FIPA 1PPOA 2IBIA 1M6DA 1FH0A 1ZCMA 1TLOA 5PADA 5KO3A 3BPFA 4OVZA 2XU5A 2AU1A 2GHUA 1JQPA 3QT4A 5K16A 2R6NA 4XZXA 8PCHA 2DC9A 4BOQA 4P16A 1U9WA 4I04A 1ZIVA 1EWOA 5CHVA 4PI3A 1KFUL 3WXFA 2YJ9A 2AS8A 4PT5A 4W5BA 2P7UA 4P6GA 3BCNA 1S4VA 4RNAA 4BOZA 4X6HA 2XU3A 4GUAA 2FRAA 2VHFA 5EF4A 3QSDA 3LFYA 1AU0A 2AUZA 3P5UA 4BOSA 4DMYA 4BOPA 4YYQA 3AI8A 1PE6A 4BS6A 4YV8A 4IP3A 1KHQA 2DCCA 3BC3A 3GCBA 2JTCA 1GCBA 1CV8A 1EWMA 3H8CA 1MS6A 1PXVA 3PRPA 3H89A 1AYWA 3CH2X 2FTDA 3PNRA 4QBBA 3H8BA 3P5WA 3S3RA 2DCBA 1GMYA 1PIPA 1AYVA 1QDQA 1KFXL 2NQDB 1O0EA 4MI7A 1PADA 2H7JA 2BU3A 2DZZA 2DC7A 1NPZA 3BPMA 4X6IA 1EWPA 2FQ9A 4BSQA 1CTEA 2DZYA 2FO5A 1YT7A 2NQIA 3F5VA 3RVXA 2JQGR 3C0RA 2Z84A 3KKUA 2OULA 3PSEA 3HHIA 1Q6KA 4IUMA 2AYOA 1NQCA 1VSNA 3F75A 4I07A 4RF1A 1U5IA 2FYEA 3KWZA 3O0UA 3D6SA 4D8BA 3OISA 1BGOA 2P0RA 4OEMA 1ICFA 2B1MA 5E6JA 4ZUXU 1ME4A 7PCKA 2PREA 2R9FA 3O65A 4HXDB 1Y08A 3W31A 3PHWA 4W5CA 3IEJA 1CVZA 1TU6A 4RY2A 4M0WA 4DMXA 1THEA 2BDZA 1NL6A 4QRVA 1IWDA 3ERVA 3N4CA 4Q8GA 2YJBA 1POPA 2FUDA 3PDFA 5F02A 5A24A 1MEMA 4XUIA 3WXEA 1DF0A 4YVAA 1AIMA 3BBAA 3MHHA 2FT2A 2OP3A 5JA7A 2HH5A 1MDWA 4BS5A 2NQAA 4PP1A 2G8EA 4RF0A 1PPPA 1AU4A 3HD3A 5EZSA 4YYVA 3RVVA 1AU2A 2YJ8A 3IFUA 2FRQA 3S3QA 4XR7A 2R9MA 4PADA 2JRIA 1U9XA 1MHWA 2G8JA 1QMYA 4OELA 2HXZA 4AXMA 3PRMA 2DOSA 1KXRA 1YVBA 3TMPA 1UKFA 4YYRA 3OF9A 1QOLA 3IUTA 4N4ZA 2AGAA 2IPPB 3RVWA 4QRXA 2WBFX 5JZEA 4K7CA 2J7QA 3DF0A 3MTNA 1Y4HA
chains in the Genus database with same CATH topology
2XU4A 2AVWA 3U8EA 2C0YA 4FK5A 3K8UA 3OF8A 2G7YA 1GECE 3IHPA 3K24A 3USVA 2AIMA 3WXGA 1EF7A 2ATOA 1X9YA 3BWKA 1ATKA 1U9QX 4CZWA 4MSXA 1BQIA 4GUZA 3LTWA 3CBKA 2E02A 3CBJA 4Q8HA 1F2CA 2DC8A 1YALA 3LXSA 4BPVA 4YYWA 1F2AA 2DCAA 3TNXA 3KSEA 4X6JA 4I05A 9PAPA 5J94A 3QJ3A 2G6DA 5EGWA 3KFQA 4PP2E 4G54A 1PPNA 3H6SA 3V6EA 3KWBX 1SNKA 2F7DA 2DJGB 1PPDA 1CSBB 2VFCA 1SP4B 3C9EA 4HWYA 1AU3A 4FJCA 2P86A 4NV7A 1A6RA 2YJ2A 1VJVA 3MHSA 3HHAA 2HD5A 2ARYA 2VFBA 3IMAA 3KW9A 1NB5A 2R9CA 2PBHA 3P5VA 2XU1A 1AYUA 4QH6A 4CDDB 1K3BB 3O1GA 4N79A 2JQFR 1GX3A 1TL9A 2HHNA 1CS8A 3M99A 2AUXA 1GLOA 1PBHA 1NLJA 4BGFA 1CPJA 1F2BA 1ITOA 3HWNA 5CVMA 2CB5A 2CIOA 5JH3A 2R9OA 2Y6EA 1DEUA 5CVOB 1PCIA 2O6XA 3CH3X 3N3GA 3ZUAA 3OVXA 2NQGA 1CJLA 4AXLA 2F1GA 2B1NA 3MORA 1MIRA 1MEGA 3P5XA 3OVZA 1NB3A 4CDEB 4P6EA 3IV2A 3K9MA 2E00A 2DCDA 4WA6A 2DC6A 5FPWA 2OZ2A 4NV8A 2PNSA 1W6FA 2ACTA 1ME3A 3I3TA 3PBHA 2E03A 3KX1A 3N3KA 5CVNB 1BP4A 3PW3A 3V6CA 4N8WA 3NHEA 1BY8A 2DJFB 4W4UA 4BQVA 3H7DA 1KHPA 4KLBA 1HUCB 1QXPA 1F29A 1XKGA 1CB5A 1CQDA 4CDFB 2E01A 2GFOA 2Y5BA 1W4TA 4MZOA 4YYSA 3I06A 3D9WA 3BOWA 3IOQA 4MZSA 2YJCA 1YK8A 6PADA 3E1ZB 2AYNA 1EWLA 4YYUA 1U9VA 4QRGA 1YK7A 2BDLA 2VHSA 1STFE 4CDCB 2PADA 1AECA 5CHTA 3B79A 2R9NA 4FIPA 1PPOA 2IBIA 1M6DA 1FH0A 1ZCMA 1TLOA 5PADA 3BPFA 2XU5A 2AU1A 2GHUA 1JQPA 3QT4A 1E2TA 5K16A 2R6NA 8PCHA 2DC9A 1U9WA 4I04A 1ZIVA 1EWOA 5CHVA 4PI3A 1KFUL 3WXFA 2YJ9A 2AS8A 4W5BA 2P7UA 4P6GA 3BCNA 1S4VA 4X6HA 2XU3A 2FRAA 2VHFA 5EF4A 3QSDA 3LFYA 1AU0A 2AUZA 3P5UA 4DMYA 4YYQA 3AI8A 1PE6A 4BS6A 4YV8A 1KHQA 2DCCA 3BC3A 3GCBA 1GCBA 1CV8A 1EWMA 3H8CA 1MS6A 1PXVA 3H89A 1AYWA 3CH2X 2FTDA 3PNRA 4QBBA 3H8BA 3P5WA 3S3RA 2DCBA 1GMYA 1PIPA 1AYVA 1QDQA 1KFXL 2NQDB 1O0EA 1PADA 2H7JA 2DZZA 2DC7A 1NPZA 3BPMA 4X6IA 1EWPA 2FQ9A 4BSQA 1CTEA 2DZYA 2FO5A 1YT7A 2NQIA 3F5VA 3RVXA 2JQGR 3KKUA 2OULA 4C5PA 3HHIA 1Q6KA 2AYOA 1NQCA 1VSNA 3F75A 4I07A 1U5IA 2FYEA 3KWZA 3O0UA 3D6SA 2BSZA 3OISA 1BGOA 2P0RA 4OEMA 1ICFA 2B1MA 4ZUXU 1ME4A 7PCKA 2PREA 2R9FA 1Y08A 4W5CA 3IEJA 1CVZA 1TU6A 4RY2A 4DMXA 1THEA 2BDZA 1NL6A 4QRVA 1IWDA 3ERVA 3N4CA 4Q8GA 2YJBA 1POPA 2FUDA 3PDFA 5F02A 4B55A 5A24A 1MEMA 4XUIA 3WXEA 1DF0A 4YVAA 1AIMA 3MHHA 2FT2A 2OP3A 1W5RA 5JA7A 2HH5A 1MDWA 4BS5A 2NQAA 4PP1A 2G8EA 1PPPA 1AU4A 3HD3A 4YYVA 3RVVA 1AU2A 2YJ8A 2FRQA 3S3QA 4XR7A 2R9MA 4PADA 1U9XA 1MHWA 2G8JA 1QMYA 4OELA 2HXZA 4AXMA 1KXRA 1YVBA 4YYRA 3OF9A 1QOLA 3IUTA 4N4ZA 2IPPB 3RVWA 4QRXA 2WBFX 4K7CA 3DF0A 3MTNA 1Y4HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XU4 A;  2AVW A;  3U8E A;  2C0Y A;  4FK5 A;  3K8U A;  3OF8 A;  2G7Y A;  1GEC E;  3IHP A;  3K24 A;  3USV A;  2AIM A;  3WXG A;  1EF7 A;  2ATO A;  1X9Y A;  3BWK A;  1ATK A;  1U9Q X;  4CZW A;  4MSX A;  1BQI A;  3CBK A;  2E02 A;  3CBJ A;  4Q8H A;  1F2C A;  2DC8 A;  1YAL A;  3LXS A;  4BPV A;  4YYW A;  1F2A A;  2DCA A;  3TNX A;  3KSE A;  4X6J A;  4I05 A;  9PAP A;  5J94 A;  3QJ3 A;  2G6D A;  5EGW A;  3KFQ A;  4PP2 E;  4G54 A;  1PPN A;  3H6S A;  3V6E A;  3KWB X;  1SNK A;  2F7D A;  2DJG B;  1PPD A;  1CSB B;  1SP4 B;  3C9E A;  4HWY A;  1AU3 A;  4FJC A;  2P86 A;  1A6R A;  2YJ2 A;  1VJV A;  3MHS A;  3HHA A;  2HD5 A;  2ARY A;  3IMA A;  3KW9 A;  1NB5 A;  2R9C A;  2PBH A;  3P5V A;  2XU1 A;  1AYU A;  4QH6 A;  4CDD B;  1K3B B;  3O1G A;  4N79 A;  2JQF R;  1TL9 A;  2HHN A;  1CS8 A;  3M99 A;  2AUX A;  1GLO A;  1PBH A;  1NLJ A;  1CPJ A;  1F2B A;  1ITO A;  3HWN A;  5CVM A;  2CB5 A;  2CIO A;  5JH3 A;  2R9O A;  2Y6E A;  1DEU A;  5CVO B;  1PCI A;  2O6X A;  3CH3 X;  3N3G A;  3ZUA A;  3OVX A;  2NQG A;  1CJL A;  4AXL A;  2F1G A;  2B1N A;  3MOR A;  1MIR A;  1MEG A;  3P5X A;  3OVZ A;  1NB3 A;  4CDE B;  4P6E A;  3IV2 A;  3K9M A;  2E00 A;  2DCD A;  4WA6 A;  2DC6 A;  5FPW A;  2OZ2 A;  2PNS A;  2ACT A;  1ME3 A;  3I3T A;  3PBH A;  2E03 A;  3KX1 A;  3N3K A;  5CVN B;  1BP4 A;  3PW3 A;  3V6C A;  4N8W A;  3NHE A;  1BY8 A;  2DJF B;  4W4U A;  4BQV A;  3H7D A;  1KHP A;  4KLB A;  1HUC B;  1QXP A;  1F29 A;  1XKG A;  1CB5 A;  1CQD A;  4CDF B;  2E01 A;  2GFO A;  2Y5B A;  4MZO A;  4YYS A;  3I06 A;  3BOW A;  3IOQ A;  4MZS A;  2YJC A;  1YK8 A;  6PAD A;  3E1Z B;  2AYN A;  1EWL A;  4YYU A;  1U9V A;  4QRG A;  1YK7 A;  2BDL A;  2VHS A;  1STF E;  4CDC B;  2PAD A;  1AEC A;  5CHT A;  3B79 A;  2R9N A;  4FIP A;  1PPO A;  2IBI A;  1M6D A;  1FH0 A;  1ZCM A;  1TLO A;  5PAD A;  3BPF A;  2XU5 A;  2AU1 A;  2GHU A;  1JQP A;  3QT4 A;  5K16 A;  2R6N A;  8PCH A;  2DC9 A;  1U9W A;  4I04 A;  1ZIV A;  1EWO A;  5CHV A;  4PI3 A;  1KFU L;  3WXF A;  2YJ9 A;  2AS8 A;  4W5B A;  2P7U A;  4P6G A;  3BCN A;  1S4V A;  4X6H A;  2XU3 A;  2FRA A;  2VHF A;  5EF4 A;  3QSD A;  3LFY A;  1AU0 A;  2AUZ A;  3P5U A;  4DMY A;  4YYQ A;  3AI8 A;  1PE6 A;  4BS6 A;  4YV8 A;  1KHQ A;  2DCC A;  3BC3 A;  3GCB A;  1GCB A;  1CV8 A;  1EWM A;  3H8C A;  1MS6 A;  1PXV A;  3H89 A;  1AYW A;  3CH2 X;  2FTD A;  3PNR A;  4QBB A;  3H8B A;  3P5W A;  3S3R A;  2DCB A;  1GMY A;  1PIP A;  1AYV A;  1QDQ A;  1KFX L;  2NQD B;  1O0E A;  1PAD A;  2H7J A;  2DZZ A;  2DC7 A;  1NPZ A;  3BPM A;  4X6I A;  1EWP A;  2FQ9 A;  4BSQ A;  1CTE A;  2DZY A;  2FO5 A;  1YT7 A;  2NQI A;  3F5V A;  3RVX A;  2JQG R;  3KKU A;  2OUL A;  3HHI A;  1Q6K A;  2AYO A;  1NQC A;  1VSN A;  3F75 A;  4I07 A;  1U5I A;  2FYE A;  3KWZ A;  3O0U A;  3D6S A;  3OIS A;  1BGO A;  2P0R A;  4OEM A;  1ICF A;  2B1M A;  4ZUX U;  1ME4 A;  7PCK A;  2PRE A;  2R9F A;  1Y08 A;  4W5C A;  3IEJ A;  1CVZ A;  1TU6 A;  4RY2 A;  4DMX A;  1THE A;  2BDZ A;  1NL6 A;  4QRV A;  1IWD A;  3ERV A;  3N4C A;  4Q8G A;  2YJB A;  1POP A;  2FUD A;  3PDF A;  5F02 A;  5A24 A;  1MEM A;  4XUI A;  3WXE A;  1DF0 A;  4YVA A;  1AIM A;  3MHH A;  2FT2 A;  2OP3 A;  5JA7 A;  2HH5 A;  1MDW A;  4BS5 A;  2NQA A;  4PP1 A;  2G8E A;  1PPP A;  1AU4 A;  3HD3 A;  4YYV A;  3RVV A;  1AU2 A;  2YJ8 A;  2FRQ A;  3S3Q A;  4XR7 A;  2R9M A;  4PAD A;  1U9X A;  1MHW A;  2G8J A;  1QMY A;  4OEL A;  2HXZ A;  4AXM A;  1KXR A;  1YVB A;  4YYR A;  3OF9 A;  1QOL A;  3IUT A;  4N4Z A;  2IPP B;  3RVW A;  4QRX A;  2WBF X;  4K7C A;  3DF0 A;  3MTN A;  1Y4H A; 
#chains in the Genus database with same CATH topology
 2XU4 A;  2AVW A;  3U8E A;  3BY4 A;  2C0Y A;  1YZB A;  4FK5 A;  4OW0 A;  3K8U A;  3OF8 A;  2G7Y A;  1PVJ A;  1GEC E;  3IHP A;  3K24 A;  3USV A;  2AIM A;  3WXG A;  1EF7 A;  2ATO A;  1X9Y A;  3BWK A;  1ATK A;  1U9Q X;  4ZTB A;  4CZW A;  4MSX A;  1BQI A;  3OQC A;  3CBK A;  2E02 A;  3CBJ A;  4Q8H A;  1F2C A;  2DC8 A;  1YAL A;  3ZNH A;  3LXS A;  4BPV A;  4YYW A;  1F2A A;  2DCA A;  3TNX A;  3KSE A;  4X6J A;  4I05 A;  9PAP A;  5J94 A;  3QJ3 A;  2G6D A;  5EGW A;  3KFQ A;  4PP2 E;  3E9S A;  4G54 A;  1PPN A;  3H6S A;  3V6E A;  4D8E A;  3BB7 A;  3KWB X;  4D8I A;  1SNK A;  2F7D A;  2J7Q C;  2DJG B;  1PPD A;  4RKX A;  3PHU A;  1CSB B;  1DKI A;  1SP4 B;  3MP2 A;  3C9E A;  4HWY A;  1AU3 A;  4FJC A;  2P86 A;  3RNV A;  1A6R A;  2YJ2 A;  1VJV A;  3MHS A;  3HHA A;  2HD5 A;  2ARY A;  3IMA A;  3KW9 A;  4MM3 B;  1NB5 A;  4WUR A;  3W30 A;  2R9C A;  2PBH A;  3P5V A;  2XU1 A;  1AYU A;  4QH6 A;  4CDD B;  1K3B B;  3O1G A;  4N79 A;  2JQF R;  1TL9 A;  2HHN A;  1CS8 A;  3M99 A;  2AUX A;  1GLO A;  1PBH A;  5EZQ A;  1NLJ A;  3MTV A;  1CPJ A;  1F2B A;  1ITO A;  3HWN A;  5CVM A;  2CB5 A;  2CIO A;  3PHX A;  5JH3 A;  2BTW B;  2R9O A;  2Y6E A;  1DEU A;  5CVO B;  1PCI A;  2O6X A;  3CH3 X;  3MJ5 A;  3N3G A;  3ZUA A;  3OVX A;  4R3D A;  2NQG A;  1CJL A;  4AXL A;  2F1G A;  2B1N A;  4A5U A;  3MOR A;  1MIR A;  1MEG A;  3P5X A;  3OVZ A;  2BTW A;  1NB3 A;  4CDE B;  4P6E A;  3IV2 A;  3K9M A;  2E00 A;  2DCD A;  4WA6 A;  2DC6 A;  5FPW A;  2OZ2 A;  2UZJ A;  2PNS A;  2ACT A;  3TRK A;  1ME3 A;  3I3T A;  3PBH A;  2E03 A;  3KX1 A;  3N3K A;  5CVN B;  1BP4 A;  3PW3 A;  3V6C A;  4N8W A;  2FE8 A;  4REZ A;  3NHE A;  1BY8 A;  2HWK A;  3B21 A;  2DJF B;  4W4U A;  4BQV A;  3H7D A;  1KHP A;  4KLB A;  1HUC B;  1QXP A;  1F29 A;  4BOU A;  1XKG A;  1CB5 A;  1CQD A;  4CDF B;  2E01 A;  2GFO A;  2Y5B A;  4MZO A;  4YYS A;  3I06 A;  3BOW A;  3IOQ A;  4MZS A;  2YJC A;  4OVZ B;  1YK8 A;  6PAD A;  3E1Z B;  2AYN A;  1EWL A;  4YYU A;  1U9V A;  4QRG A;  1YK7 A;  2BDL A;  3PT2 A;  2VHS A;  1STF E;  4CDC B;  2PAD A;  1AEC A;  5CHT A;  3B79 A;  2R9N A;  4FIP A;  1PPO A;  2IBI A;  1M6D A;  1FH0 A;  1ZCM A;  1TLO A;  5PAD A;  5KO3 A;  3BPF A;  4OVZ A;  2XU5 A;  2AU1 A;  2GHU A;  1JQP A;  3QT4 A;  5K16 A;  2R6N A;  4XZX A;  8PCH A;  2DC9 A;  4BOQ A;  4P16 A;  1U9W A;  4I04 A;  1ZIV A;  1EWO A;  5CHV A;  4PI3 A;  1KFU L;  3WXF A;  2YJ9 A;  2AS8 A;  4PT5 A;  4W5B A;  2P7U A;  4P6G A;  3BCN A;  1S4V A;  4RNA A;  4BOZ A;  4X6H A;  2XU3 A;  4GUA A;  2FRA A;  2VHF A;  5EF4 A;  3QSD A;  3LFY A;  1AU0 A;  2AUZ A;  3P5U A;  4BOS A;  4DMY A;  4BOP A;  4YYQ A;  3AI8 A;  1PE6 A;  4BS6 A;  4YV8 A;  4IP3 A;  1KHQ A;  2DCC A;  3BC3 A;  3GCB A;  2JTC A;  1GCB A;  1CV8 A;  1EWM A;  3H8C A;  1MS6 A;  1PXV A;  3PRP A;  3H89 A;  1AYW A;  3CH2 X;  2FTD A;  3PNR A;  4QBB A;  3H8B A;  3P5W A;  3S3R A;  2DCB A;  1GMY A;  1PIP A;  1AYV A;  1QDQ A;  1KFX L;  2NQD B;  1O0E A;  4MI7 A;  1PAD A;  2H7J A;  2BU3 A;  2DZZ A;  2DC7 A;  1NPZ A;  3BPM A;  4X6I A;  1EWP A;  2FQ9 A;  4BSQ A;  1CTE A;  2DZY A;  2FO5 A;  1YT7 A;  2NQI A;  3F5V A;  3RVX A;  2JQG R;  3C0R A;  2Z84 A;  3KKU A;  2OUL A;  3PSE A;  3HHI A;  1Q6K A;  4IUM A;  2AYO A;  1NQC A;  1VSN A;  3F75 A;  4I07 A;  4RF1 A;  1U5I A;  2FYE A;  3KWZ A;  3O0U A;  3D6S A;  4D8B A;  3OIS A;  1BGO A;  2P0R A;  4OEM A;  1ICF A;  2B1M A;  5E6J A;  4ZUX U;  1ME4 A;  7PCK A;  2PRE A;  2R9F A;  3O65 A;  4HXD B;  1Y08 A;  3W31 A;  3PHW A;  4W5C A;  3IEJ A;  1CVZ A;  1TU6 A;  4RY2 A;  4M0W A;  4DMX A;  1THE A;  2BDZ A;  1NL6 A;  4QRV A;  1IWD A;  3ERV A;  3N4C A;  4Q8G A;  2YJB A;  1POP A;  2FUD A;  3PDF A;  5F02 A;  5A24 A;  1MEM A;  4XUI A;  3WXE A;  1DF0 A;  4YVA A;  1AIM A;  3BBA A;  3MHH A;  2FT2 A;  2OP3 A;  5JA7 A;  2HH5 A;  1MDW A;  4BS5 A;  2NQA A;  4PP1 A;  2G8E A;  4RF0 A;  1PPP A;  1AU4 A;  3HD3 A;  5EZS A;  4YYV A;  3RVV A;  1AU2 A;  2YJ8 A;  3IFU A;  2FRQ A;  3S3Q A;  4XR7 A;  2R9M A;  4PAD A;  2JRI A;  1U9X A;  1MHW A;  2G8J A;  1QMY A;  4OEL A;  2HXZ A;  4AXM A;  3PRM A;  2DOS A;  1KXR A;  1YVB A;  3TMP A;  1UKF A;  4YYR A;  3OF9 A;  1QOL A;  3IUT A;  4N4Z A;  2AGA A;  2IPP B;  3RVW A;  4QRX A;  2WBF X;  5JZE A;  4K7C A;  2J7Q A;  3DF0 A;  3MTN A;  1Y4H A; 
#chains in the Genus database with same CATH homology
 2XU4 A;  2AVW A;  3U8E A;  2C0Y A;  4FK5 A;  3K8U A;  3OF8 A;  2G7Y A;  1GEC E;  3IHP A;  3K24 A;  3USV A;  2AIM A;  3WXG A;  1EF7 A;  2ATO A;  1X9Y A;  3BWK A;  1ATK A;  1U9Q X;  4CZW A;  4MSX A;  1BQI A;  4GUZ A;  3LTW A;  3CBK A;  2E02 A;  3CBJ A;  4Q8H A;  1F2C A;  2DC8 A;  1YAL A;  3LXS A;  4BPV A;  4YYW A;  1F2A A;  2DCA A;  3TNX A;  3KSE A;  4X6J A;  4I05 A;  9PAP A;  5J94 A;  3QJ3 A;  2G6D A;  5EGW A;  3KFQ A;  4PP2 E;  4G54 A;  1PPN A;  3H6S A;  3V6E A;  3KWB X;  1SNK A;  2F7D A;  2DJG B;  1PPD A;  1CSB B;  2VFC A;  1SP4 B;  3C9E A;  4HWY A;  1AU3 A;  4FJC A;  2P86 A;  4NV7 A;  1A6R A;  2YJ2 A;  1VJV A;  3MHS A;  3HHA A;  2HD5 A;  2ARY A;  2VFB A;  3IMA A;  3KW9 A;  1NB5 A;  2R9C A;  2PBH A;  3P5V A;  2XU1 A;  1AYU A;  4QH6 A;  4CDD B;  1K3B B;  3O1G A;  4N79 A;  2JQF R;  1GX3 A;  1TL9 A;  2HHN A;  1CS8 A;  3M99 A;  2AUX A;  1GLO A;  1PBH A;  1NLJ A;  4BGF A;  1CPJ A;  1F2B A;  1ITO A;  3HWN A;  5CVM A;  2CB5 A;  2CIO A;  5JH3 A;  2R9O A;  2Y6E A;  1DEU A;  5CVO B;  1PCI A;  2O6X A;  3CH3 X;  3N3G A;  3ZUA A;  3OVX A;  2NQG A;  1CJL A;  4AXL A;  2F1G A;  2B1N A;  3MOR A;  1MIR A;  1MEG A;  3P5X A;  3OVZ A;  1NB3 A;  4CDE B;  4P6E A;  3IV2 A;  3K9M A;  2E00 A;  2DCD A;  4WA6 A;  2DC6 A;  5FPW A;  2OZ2 A;  4NV8 A;  2PNS A;  1W6F A;  2ACT A;  1ME3 A;  3I3T A;  3PBH A;  2E03 A;  3KX1 A;  3N3K A;  5CVN B;  1BP4 A;  3PW3 A;  3V6C A;  4N8W A;  3NHE A;  1BY8 A;  2DJF B;  4W4U A;  4BQV A;  3H7D A;  1KHP A;  4KLB A;  1HUC B;  1QXP A;  1F29 A;  1XKG A;  1CB5 A;  1CQD A;  4CDF B;  2E01 A;  2GFO A;  2Y5B A;  1W4T A;  4MZO A;  4YYS A;  3I06 A;  3D9W A;  3BOW A;  3IOQ A;  4MZS A;  2YJC A;  1YK8 A;  6PAD A;  3E1Z B;  2AYN A;  1EWL A;  4YYU A;  1U9V A;  4QRG A;  1YK7 A;  2BDL A;  2VHS A;  1STF E;  4CDC B;  2PAD A;  1AEC A;  5CHT A;  3B79 A;  2R9N A;  4FIP A;  1PPO A;  2IBI A;  1M6D A;  1FH0 A;  1ZCM A;  1TLO A;  5PAD A;  3BPF A;  2XU5 A;  2AU1 A;  2GHU A;  1JQP A;  3QT4 A;  1E2T A;  5K16 A;  2R6N A;  8PCH A;  2DC9 A;  1U9W A;  4I04 A;  1ZIV A;  1EWO A;  5CHV A;  4PI3 A;  1KFU L;  3WXF A;  2YJ9 A;  2AS8 A;  4W5B A;  2P7U A;  4P6G A;  3BCN A;  1S4V A;  4X6H A;  2XU3 A;  2FRA A;  2VHF A;  5EF4 A;  3QSD A;  3LFY A;  1AU0 A;  2AUZ A;  3P5U A;  4DMY A;  4YYQ A;  3AI8 A;  1PE6 A;  4BS6 A;  4YV8 A;  1KHQ A;  2DCC A;  3BC3 A;  3GCB A;  1GCB A;  1CV8 A;  1EWM A;  3H8C A;  1MS6 A;  1PXV A;  3H89 A;  1AYW A;  3CH2 X;  2FTD A;  3PNR A;  4QBB A;  3H8B A;  3P5W A;  3S3R A;  2DCB A;  1GMY A;  1PIP A;  1AYV A;  1QDQ A;  1KFX L;  2NQD B;  1O0E A;  1PAD A;  2H7J A;  2DZZ A;  2DC7 A;  1NPZ A;  3BPM A;  4X6I A;  1EWP A;  2FQ9 A;  4BSQ A;  1CTE A;  2DZY A;  2FO5 A;  1YT7 A;  2NQI A;  3F5V A;  3RVX A;  2JQG R;  3KKU A;  2OUL A;  4C5P A;  3HHI A;  1Q6K A;  2AYO A;  1NQC A;  1VSN A;  3F75 A;  4I07 A;  1U5I A;  2FYE A;  3KWZ A;  3O0U A;  3D6S A;  2BSZ A;  3OIS A;  1BGO A;  2P0R A;  4OEM A;  1ICF A;  2B1M A;  4ZUX U;  1ME4 A;  7PCK A;  2PRE A;  2R9F A;  1Y08 A;  4W5C A;  3IEJ A;  1CVZ A;  1TU6 A;  4RY2 A;  4DMX A;  1THE A;  2BDZ A;  1NL6 A;  4QRV A;  1IWD A;  3ERV A;  3N4C A;  4Q8G A;  2YJB A;  1POP A;  2FUD A;  3PDF A;  5F02 A;  4B55 A;  5A24 A;  1MEM A;  4XUI A;  3WXE A;  1DF0 A;  4YVA A;  1AIM A;  3MHH A;  2FT2 A;  2OP3 A;  1W5R A;  5JA7 A;  2HH5 A;  1MDW A;  4BS5 A;  2NQA A;  4PP1 A;  2G8E A;  1PPP A;  1AU4 A;  3HD3 A;  4YYV A;  3RVV A;  1AU2 A;  2YJ8 A;  2FRQ A;  3S3Q A;  4XR7 A;  2R9M A;  4PAD A;  1U9X A;  1MHW A;  2G8J A;  1QMY A;  4OEL A;  2HXZ A;  4AXM A;  1KXR A;  1YVB A;  4YYR A;  3OF9 A;  1QOL A;  3IUT A;  4N4Z A;  2IPP B;  3RVW A;  4QRX A;  2WBF X;  4K7C A;  3DF0 A;  3MTN A;  1Y4H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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