1BP4A

Use of papain as a model for the structure-based design of cathepsin k inhibitors. crystal structures of two papain inhibitor complexes demonstrate binding to s'-subsites.
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
212
structure length
212
Chain Sequence
IPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNQYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNQGALLYSIANQPVSVVLQAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PAPAIN
total genus 66
structure length 212
sequence length 212
ec nomenclature ec 3.4.22.2: Papain.
pdb deposition date 1998-08-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1bp4A00
2IBIA 4KLBA 1MIRA 6PADA 5EGWA 2VHFA 3IHPA 3CBJA 5JA7A 4QRGA 3P5VA 2YJBA 4PP2E 1EWPA 4MSXA 1ME3A 1GCBA 3OVXA 2B1MA 4YYWA 2AYNA 2NQGA 1PBHA 3BCNA 3H8CA 1HUCB 3HWNA 4G54A 2PADA 1KFXL 1TU6A 3P5XA 3MORA 2O6XA 2HHNA 4I07A 4YYQA 1NB3A 3BWKA 2FYEA 4OEMA 3QSDA 1BY8A 4YVAA 1PIPA 5CHTA 1MEMA 2E00A 2Y6EA 3WXEA 4YV8A 2DC7A 2PNSA 2YJ8A 2YJCA 1AU0A 4BS6A 5PADA 4YYSA 1NB5A 2E01A 4PI3A 2AU1A 4WA6A 2HH5A 2F7DA 2HD5A 2XU1A 1CPJA 2FQ9A 3K24A 3S3QA 1GECE 1XKGA 2ATOA 5CVNB 1YVBA 3HHIA 1Y4HA 4PADA 4PP1A 5JH3A 1PPOA 3HHAA 1TL9A 4CDCB 4FIPA 2IPPB 3MTNA 3OF8A 3HD3A 3RVXA 3PBHA 2E03A 2DJGB 4CDEB 4XR7A 2NQAA 1KHQA 4I04A 3KWZA 2XU3A 1S4VA 4QRXA 3BC3A 2NQDB 4Q8HA 3RVWA 5K16A 2ACTA 4QBBA 2P86A 3RVVA 1NPZA 2R9MA 2AUZA 1PCIA 3M99A 2WBFX 1GMYA 2JQFR 1EF7A 2AYOA 4W5BA 3U8EA 1FH0A 3K8UA 2BDLA 1BGOA 1KFUL 4OELA 9PAPA 2AVWA 4X6JA 1MDWA 1Y08A 4I05A 2AUXA 2CIOA 1AYWA 3OVZA 2DCBA 3NHEA 1F2AA 1BP4A 3LXSA 2FRAA 2R9FA 1PPPA 3V6CA 3WXGA 1YALA 4BS5A 4N8WA 2DJFB 3IUTA 5CHVA 2R9CA 1CS8A 1YT7A 1U9VA 7PCKA 3H89A 4DMXA 3KKUA 4P6GA 1GLOA 1SP4B 2ARYA 2FTDA 1DEUA 1AU2A 1Q6KA 1QXPA 3ZUAA 3MHHA 3N3KA 2R6NA 3IEJA 4N79A 4YYRA 2PREA 3N4CA 4QH6A 1YK7A 3BOWA 4QRVA 4W4UA 1A6RA 2XU4A 1JQPA 1ZCMA 1AECA 3KFQA 2CB5A 1CB5A 2OZ2A 3B79A 4FJCA 4BQVA 2NQIA 3P5UA 1NL6A 1BQIA 3F5VA 2DZZA 4MZSA 1X9YA 2G6DA 1DF0A 2OULA 4MZOA 1NQCA 2Y5BA 1AYUA 4CDDB 1M6DA 1ZIVA 1YK8A 1F2BA 3MHSA 4CDFB 3C9EA 3H8BA 3KW9A 2B1NA 1TLOA 1AU3A 2GHUA 1CVZA 2FUDA 2P7UA 1STFE 2YJ2A 4P6EA 3TNXA 2VHSA 1PADA 3OISA 4AXLA 3AI8A 3QT4A 4CZWA 2BDZA 1QOLA 2FO5A 2DC9A 4X6HA 4HWYA 2G8JA 2H7JA 2HXZA 3KWBX 1U5IA 1KXRA 3OF9A 5J94A 8PCHA 4RY2A 4W5CA 3ERVA 3PDFA 1QDQA 2R9OA 3QJ3A 1CQDA 4ZUXU 3CH2X 1PPNA 1U9QX 3CH3X 2PBHA 1VJVA 1U9WA 4N4ZA 3P5WA 1CSBB 2DZYA 3USVA 1MHWA 5FPWA 3E1ZB 3IV2A 3PNRA 1O0EA 1PPDA 3IMAA 3O0UA 3WXFA 3F75A 5CVOB 3BPMA 3IOQA 1POPA 2FT2A 3I3TA 3I06A 2G8EA 3KSEA 2C0YA 4BPVA 1CV8A 1VSNA 3KX1A 2AS8A 5CVMA 3CBKA 2GFOA 5EF4A 2R9NA 1MEGA 3GCBA 2F1GA 1IWDA 1F29A 4YYUA 2DCDA 1EWLA 2P0RA 1ITOA 1SNKA 1AYVA 3K9MA 5F02A 1PE6A 3LFYA 3H7DA 2G7YA 4K7CA 1AU4A 2DC8A 1U9XA 4XUIA 2OP3A 1NLJA 2E02A 3N3GA 2DCAA 1CJLA 3D6SA 1EWMA 2DC6A 2JQGR 4X6IA 3BPFA 5A24A 1ME4A 1EWOA 1K3BB 2DCCA 1MS6A 1CTEA 2YJ9A 4DMYA 4AXMA 1KHPA 3DF0A 2FRQA 2AIMA 1AIMA 1THEA 3H6SA 1PXVA 1F2CA 2XU5A 4FK5A 3V6EA 4BSQA 4YYVA 1QMYA 3S3RA 3PW3A 1ICFA 4Q8GA 3O1GA 1ATKA
chains in the Genus database with same CATH superfamily
2IBIA 4A5UA 4KLBA 1MIRA 3PRMA 6PADA 5EGWA 2VHFA 3TRKA 3IHPA 3CBJA 5JA7A 4QRGA 3P5VA 4D8EA 2YJBA 4PP2E 1EWPA 4MSXA 1ME3A 1GCBA 3OVXA 2B1MA 4YYWA 2AYNA 2NQGA 1PBHA 3BCNA 3H8CA 1HUCB 3HWNA 4G54A 4RKXA 3BY4A 1YZBA 2PADA 1KFXL 1TU6A 3P5XA 3RNVA 2J7QA 3MORA 2O6XA 2HHNA 4M0WA 3ZNHA 4I07A 4YYQA 1NB3A 3BWKA 2FYEA 4OEMA 3QSDA 1BY8A 4YVAA 2AGAA 1PIPA 5CHTA 1MEMA 2E00A 4MI7A 2Y6EA 3WXEA 4YV8A 2DC7A 2PNSA 2YJ8A 2YJCA 4BOZA 1AU0A 4BS6A 5PADA 4YYSA 1NB5A 3TMPA 2E01A 4PI3A 2AU1A 4WA6A 3O65A 2HH5A 2F7DA 2HD5A 2XU1A 1CPJA 2FQ9A 3K24A 3S3QA 1GECE 1XKGA 2ATOA 5CVNB 1YVBA 3HHIA 1Y4HA 4PADA 4PP1A 5JH3A 4MM3B 1PPOA 3HHAA 1UKFA 1TL9A 4CDCB 4FIPA 2IPPB 3MTNA 3OF8A 3HD3A 3RVXA 3PBHA 2E03A 2DJGB 4CDEB 3W31A 4XR7A 2NQAA 1KHQA 4I04A 3KWZA 2XU3A 1S4VA 4QRXA 3BC3A 2NQDB 4Q8HA 3BB7A 3RVWA 5K16A 2ACTA 4QBBA 2BTWA 2P86A 3RVVA 1NPZA 2R9MA 4IUMA 2JRIA 2Z84A 2AUZA 1PCIA 3M99A 2WBFX 1GMYA 5JZEA 2JQFR 1EF7A 2AYOA 4W5BA 3U8EA 1FH0A 3K8UA 2BDLA 4RF1A 1BGOA 1KFUL 4OELA 9PAPA 2AVWA 4X6JA 1MDWA 1Y08A 4XZXA 2UZJA 4I05A 2AUXA 2CIOA 1AYWA 3OVZA 2DCBA 3NHEA 1F2AA 1BP4A 3LXSA 2FRAA 2R9FA 1PPPA 3V6CA 3WXGA 3PHXA 4WURA 1YALA 4BS5A 3PHUA 4N8WA 2DJFB 4BOUA 3IUTA 5CHVA 2R9CA 1CS8A 1YT7A 1U9VA 7PCKA 3H89A 4DMXA 3KKUA 4P6GA 1GLOA 1SP4B 2BTWB 2ARYA 2FTDA 1DEUA 4D8IA 4BOSA 1AU2A 1Q6KA 1QXPA 3ZUAA 3MHHA 3N3KA 2R6NA 3IEJA 4N79A 4YYRA 2PREA 3E9SA 3N4CA 4QH6A 1YK7A 3BOWA 4QRVA 4W4UA 1A6RA 2XU4A 4BOPA 1JQPA 1ZCMA 1AECA 3KFQA 2CB5A 1CB5A 2OZ2A 3B79A 4RF0A 3MP2A 4FJCA 4BQVA 2NQIA 3P5UA 1NL6A 1BQIA 3F5VA 2DOSA 2DZZA 4MZSA 1X9YA 2BU3A 2G6DA 5KO3A 1DF0A 2OULA 4R3DA 4MZOA 1NQCA 3OQCA 2Y5BA 1AYUA 4CDDB 1M6DA 1ZIVA 1YK8A 1F2BA 3MHSA 4CDFB 3C9EA 3H8BA 2HWKA 3KW9A 2B1NA 1TLOA 1AU3A 4HXDB 2GHUA 1CVZA 2FUDA 2P7UA 1STFE 2YJ2A 4P6EA 3TNXA 2VHSA 1PADA 3OISA 4AXLA 3AI8A 3QT4A 4CZWA 2BDZA 1QOLA 2FO5A 2DC9A 4X6HA 4HWYA 2G8JA 2H7JA 2HXZA 3KWBX 1U5IA 1KXRA 3OF9A 5J94A 8PCHA 4OW0A 4RY2A 4W5CA 3ERVA 3PDFA 1QDQA 2R9OA 1DKIA 2J7QC 3QJ3A 1CQDA 4ZUXU 1PVJA 3CH2X 1PPNA 3IFUA 1U9QX 3CH3X 5EZQA 2PBHA 1VJVA 1U9WA 4N4ZA 3P5WA 1CSBB 2DZYA 3USVA 1MHWA 3BBAA 5FPWA 3E1ZB 3IV2A 3PNRA 1O0EA 1PPDA 3IMAA 3O0UA 4PT5A 3WXFA 3F75A 5CVOB 3BPMA 4OVZA 3IOQA 1POPA 2FT2A 4IP3A 4RNAA 3I3TA 3I06A 3MJ5A 2G8EA 3KSEA 4ZTBA 4BOQA 2C0YA 4BPVA 1CV8A 3PT2A 1VSNA 3KX1A 2AS8A 5CVMA 3CBKA 2GFOA 5EF4A 2R9NA 1MEGA 3B21A 3GCBA 2F1GA 1IWDA 1F29A 4YYUA 2DCDA 1EWLA 2P0RA 1ITOA 1SNKA 4GUAA 1AYVA 3K9MA 3PHWA 5F02A 1PE6A 3LFYA 3H7DA 2G7YA 4K7CA 1AU4A 2DC8A 1U9XA 4XUIA 2OP3A 1NLJA 3C0RA 2E02A 3N3GA 2DCAA 1CJLA 4P16A 4OVZB 3D6SA 1EWMA 2FE8A 2DC6A 2JQGR 4X6IA 3BPFA 5A24A 1ME4A 2JTCA 3PRPA 1EWOA 1K3BB 2DCCA 1MS6A 1CTEA 5E6JA 2YJ9A 4REZA 4DMYA 4AXMA 1KHPA 3PSEA 3DF0A 2FRQA 4D8BA 2AIMA 1AIMA 1THEA 3H6SA 1PXVA 3W30A 1F2CA 3MTVA 2XU5A 4FK5A 3V6EA 4BSQA 4YYVA 1QMYA 3S3RA 3PW3A 1ICFA 4Q8GA 5EZSA 3O1GA 1ATKA
chains in the Genus database with same CATH topology
2IBIA 4KLBA 1MIRA 6PADA 5EGWA 2VHFA 3IHPA 3CBJA 5JA7A 4QRGA 3P5VA 2YJBA 4PP2E 1EWPA 4MSXA 1ME3A 1GCBA 3OVXA 2B1MA 4YYWA 2AYNA 2NQGA 1PBHA 3BCNA 3H8CA 1HUCB 3HWNA 4G54A 2PADA 1KFXL 1TU6A 3P5XA 3MORA 2O6XA 2HHNA 4I07A 4YYQA 1NB3A 3BWKA 2FYEA 4OEMA 3QSDA 1BY8A 4YVAA 1PIPA 5CHTA 1MEMA 2E00A 2Y6EA 3WXEA 4YV8A 2DC7A 2PNSA 2YJ8A 2YJCA 1AU0A 4BS6A 5PADA 4YYSA 1NB5A 2E01A 4PI3A 2AU1A 4WA6A 2HH5A 2F7DA 2HD5A 2XU1A 1CPJA 2FQ9A 3K24A 3S3QA 1GECE 1XKGA 2ATOA 5CVNB 1YVBA 3HHIA 1Y4HA 4PADA 4PP1A 5JH3A 1PPOA 3HHAA 4B55A 1TL9A 4CDCB 4FIPA 2IPPB 3MTNA 3OF8A 3HD3A 4NV8A 3PBHA 3RVXA 2E03A 2DJGB 4CDEB 4XR7A 2BSZA 2NQAA 1KHQA 4I04A 3KWZA 2XU3A 1S4VA 4QRXA 3BC3A 2NQDB 4Q8HA 3RVWA 5K16A 2ACTA 4QBBA 2P86A 3RVVA 1NPZA 2R9MA 2AUZA 1PCIA 3M99A 2WBFX 1GMYA 2JQFR 1EF7A 2AYOA 4W5BA 3U8EA 1FH0A 3K8UA 2BDLA 1BGOA 1KFUL 4OELA 9PAPA 2AVWA 4X6JA 1MDWA 1Y08A 4I05A 2AUXA 2CIOA 1AYWA 3OVZA 2DCBA 3NHEA 1F2AA 1BP4A 3LXSA 2FRAA 2R9FA 1PPPA 3V6CA 3WXGA 1YALA 4BS5A 2VFBA 4N8WA 2DJFB 3IUTA 5CHVA 2R9CA 1CS8A 1YT7A 1U9VA 7PCKA 3H89A 4DMXA 3KKUA 4P6GA 1GLOA 1SP4B 2ARYA 2FTDA 1DEUA 1W5RA 4NV7A 1AU2A 1Q6KA 1QXPA 3ZUAA 3MHHA 3N3KA 2R6NA 3IEJA 4N79A 4YYRA 2PREA 3N4CA 4BGFA 4QH6A 3D9WA 1YK7A 3BOWA 4QRVA 4W4UA 1A6RA 2XU4A 1JQPA 1ZCMA 1AECA 3KFQA 2CB5A 4GUZA 1CB5A 2OZ2A 3B79A 4FJCA 4BQVA 2NQIA 3P5UA 1GX3A 1NL6A 1BQIA 3F5VA 2DZZA 4MZSA 1X9YA 2G6DA 1DF0A 2OULA 4MZOA 1NQCA 2Y5BA 1AYUA 4CDDB 1M6DA 1ZIVA 1YK8A 1F2BA 3MHSA 4CDFB 3C9EA 3H8BA 3KW9A 2B1NA 1TLOA 1AU3A 2GHUA 1CVZA 2FUDA 2P7UA 1STFE 2YJ2A 4P6EA 3TNXA 2VHSA 1PADA 3OISA 4AXLA 3AI8A 3QT4A 4CZWA 2BDZA 1QOLA 2FO5A 2DC9A 4X6HA 4HWYA 2G8JA 2H7JA 2HXZA 3KWBX 1U5IA 1KXRA 3OF9A 5J94A 8PCHA 4RY2A 4W5CA 3ERVA 3PDFA 1QDQA 2R9OA 3QJ3A 1CQDA 4ZUXU 3CH2X 1PPNA 1U9QX 3CH3X 2PBHA 1VJVA 1U9WA 1W6FA 4N4ZA 3P5WA 1CSBB 2DZYA 3USVA 1MHWA 5FPWA 3E1ZB 3IV2A 3PNRA 1O0EA 1PPDA 3IMAA 3O0UA 3WXFA 3F75A 5CVOB 3BPMA 3IOQA 1POPA 2FT2A 3I3TA 3I06A 2G8EA 3KSEA 2C0YA 4BPVA 1CV8A 1VSNA 3KX1A 2AS8A 5CVMA 3CBKA 2GFOA 5EF4A 2R9NA 1MEGA 3GCBA 2F1GA 1IWDA 1F29A 4YYUA 2DCDA 1EWLA 2P0RA 1ITOA 1SNKA 1AYVA 3K9MA 5F02A 1PE6A 3LFYA 3H7DA 2G7YA 3LTWA 4K7CA 1AU4A 2DC8A 1U9XA 4XUIA 2OP3A 1NLJA 2E02A 3N3GA 2DCAA 1CJLA 3D6SA 1EWMA 2DC6A 2JQGR 4X6IA 3BPFA 5A24A 1ME4A 1EWOA 1K3BB 2DCCA 1MS6A 1CTEA 2VFCA 2YJ9A 4DMYA 4AXMA 1W4TA 1E2TA 1KHPA 3DF0A 2FRQA 2AIMA 1AIMA 1THEA 3H6SA 1PXVA 1F2CA 2XU5A 4FK5A 3V6EA 4BSQA 4C5PA 4YYVA 1QMYA 3S3RA 3PW3A 1ICFA 4Q8GA 3O1GA 1ATKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IBI A;  4KLB A;  1MIR A;  6PAD A;  5EGW A;  2VHF A;  3IHP A;  3CBJ A;  5JA7 A;  4QRG A;  3P5V A;  2YJB A;  4PP2 E;  1EWP A;  4MSX A;  1ME3 A;  1GCB A;  3OVX A;  2B1M A;  4YYW A;  2AYN A;  2NQG A;  1PBH A;  3BCN A;  3H8C A;  1HUC B;  3HWN A;  4G54 A;  2PAD A;  1KFX L;  1TU6 A;  3P5X A;  3MOR A;  2O6X A;  2HHN A;  4I07 A;  4YYQ A;  1NB3 A;  3BWK A;  2FYE A;  4OEM A;  3QSD A;  1BY8 A;  4YVA A;  1PIP A;  5CHT A;  1MEM A;  2E00 A;  2Y6E A;  3WXE A;  4YV8 A;  2DC7 A;  2PNS A;  2YJ8 A;  2YJC A;  1AU0 A;  4BS6 A;  5PAD A;  4YYS A;  1NB5 A;  2E01 A;  4PI3 A;  2AU1 A;  4WA6 A;  2HH5 A;  2F7D A;  2HD5 A;  2XU1 A;  1CPJ A;  2FQ9 A;  3K24 A;  3S3Q A;  1GEC E;  1XKG A;  2ATO A;  5CVN B;  1YVB A;  3HHI A;  1Y4H A;  4PAD A;  4PP1 A;  5JH3 A;  1PPO A;  3HHA A;  1TL9 A;  4CDC B;  4FIP A;  2IPP B;  3MTN A;  3OF8 A;  3HD3 A;  3RVX A;  3PBH A;  2E03 A;  2DJG B;  4CDE B;  4XR7 A;  2NQA A;  1KHQ A;  4I04 A;  3KWZ A;  2XU3 A;  1S4V A;  4QRX A;  3BC3 A;  2NQD B;  4Q8H A;  3RVW A;  5K16 A;  2ACT A;  4QBB A;  2P86 A;  3RVV A;  1NPZ A;  2R9M A;  2AUZ A;  1PCI A;  3M99 A;  2WBF X;  1GMY A;  2JQF R;  1EF7 A;  2AYO A;  4W5B A;  3U8E A;  1FH0 A;  3K8U A;  2BDL A;  1BGO A;  1KFU L;  4OEL A;  9PAP A;  2AVW A;  4X6J A;  1MDW A;  1Y08 A;  4I05 A;  2AUX A;  2CIO A;  1AYW A;  3OVZ A;  2DCB A;  3NHE A;  1F2A A;  1BP4 A;  3LXS A;  2FRA A;  2R9F A;  1PPP A;  3V6C A;  3WXG A;  1YAL A;  4BS5 A;  4N8W A;  2DJF B;  3IUT A;  5CHV A;  2R9C A;  1CS8 A;  1YT7 A;  1U9V A;  7PCK A;  3H89 A;  4DMX A;  3KKU A;  4P6G A;  1GLO A;  1SP4 B;  2ARY A;  2FTD A;  1DEU A;  1AU2 A;  1Q6K A;  1QXP A;  3ZUA A;  3MHH A;  3N3K A;  2R6N A;  3IEJ A;  4N79 A;  4YYR A;  2PRE A;  3N4C A;  4QH6 A;  1YK7 A;  3BOW A;  4QRV A;  4W4U A;  1A6R A;  2XU4 A;  1JQP A;  1ZCM A;  1AEC A;  3KFQ A;  2CB5 A;  1CB5 A;  2OZ2 A;  3B79 A;  4FJC A;  4BQV A;  2NQI A;  3P5U A;  1NL6 A;  1BQI A;  3F5V A;  2DZZ A;  4MZS A;  1X9Y A;  2G6D A;  1DF0 A;  2OUL A;  4MZO A;  1NQC A;  2Y5B A;  1AYU A;  4CDD B;  1M6D A;  1ZIV A;  1YK8 A;  1F2B A;  3MHS A;  4CDF B;  3C9E A;  3H8B A;  3KW9 A;  2B1N A;  1TLO A;  1AU3 A;  2GHU A;  1CVZ A;  2FUD A;  2P7U A;  1STF E;  2YJ2 A;  4P6E A;  3TNX A;  2VHS A;  1PAD A;  3OIS A;  4AXL A;  3AI8 A;  3QT4 A;  4CZW A;  2BDZ A;  1QOL A;  2FO5 A;  2DC9 A;  4X6H A;  4HWY A;  2G8J A;  2H7J A;  2HXZ A;  3KWB X;  1U5I A;  1KXR A;  3OF9 A;  5J94 A;  8PCH A;  4RY2 A;  4W5C A;  3ERV A;  3PDF A;  1QDQ A;  2R9O A;  3QJ3 A;  1CQD A;  4ZUX U;  3CH2 X;  1PPN A;  1U9Q X;  3CH3 X;  2PBH A;  1VJV A;  1U9W A;  4N4Z A;  3P5W A;  1CSB B;  2DZY A;  3USV A;  1MHW A;  5FPW A;  3E1Z B;  3IV2 A;  3PNR A;  1O0E A;  1PPD A;  3IMA A;  3O0U A;  3WXF A;  3F75 A;  5CVO B;  3BPM A;  3IOQ A;  1POP A;  2FT2 A;  3I3T A;  3I06 A;  2G8E A;  3KSE A;  2C0Y A;  4BPV A;  1CV8 A;  1VSN A;  3KX1 A;  2AS8 A;  5CVM A;  3CBK A;  2GFO A;  5EF4 A;  2R9N A;  1MEG A;  3GCB A;  2F1G A;  1IWD A;  1F29 A;  4YYU A;  2DCD A;  1EWL A;  2P0R A;  1ITO A;  1SNK A;  1AYV A;  3K9M A;  5F02 A;  1PE6 A;  3LFY A;  3H7D A;  2G7Y A;  4K7C A;  1AU4 A;  2DC8 A;  1U9X A;  4XUI A;  2OP3 A;  1NLJ A;  2E02 A;  3N3G A;  2DCA A;  1CJL A;  3D6S A;  1EWM A;  2DC6 A;  2JQG R;  4X6I A;  3BPF A;  5A24 A;  1ME4 A;  1EWO A;  1K3B B;  2DCC A;  1MS6 A;  1CTE A;  2YJ9 A;  4DMY A;  4AXM A;  1KHP A;  3DF0 A;  2FRQ A;  2AIM A;  1AIM A;  1THE A;  3H6S A;  1PXV A;  1F2C A;  2XU5 A;  4FK5 A;  3V6E A;  4BSQ A;  4YYV A;  1QMY A;  3S3R A;  3PW3 A;  1ICF A;  4Q8G A;  3O1G A;  1ATK A; 
#chains in the Genus database with same CATH topology
 2IBI A;  4A5U A;  4KLB A;  1MIR A;  3PRM A;  6PAD A;  5EGW A;  2VHF A;  3TRK A;  3IHP A;  3CBJ A;  5JA7 A;  4QRG A;  3P5V A;  4D8E A;  2YJB A;  4PP2 E;  1EWP A;  4MSX A;  1ME3 A;  1GCB A;  3OVX A;  2B1M A;  4YYW A;  2AYN A;  2NQG A;  1PBH A;  3BCN A;  3H8C A;  1HUC B;  3HWN A;  4G54 A;  4RKX A;  3BY4 A;  1YZB A;  2PAD A;  1KFX L;  1TU6 A;  3P5X A;  3RNV A;  2J7Q A;  3MOR A;  2O6X A;  2HHN A;  4M0W A;  3ZNH A;  4I07 A;  4YYQ A;  1NB3 A;  3BWK A;  2FYE A;  4OEM A;  3QSD A;  1BY8 A;  4YVA A;  2AGA A;  1PIP A;  5CHT A;  1MEM A;  2E00 A;  4MI7 A;  2Y6E A;  3WXE A;  4YV8 A;  2DC7 A;  2PNS A;  2YJ8 A;  2YJC A;  4BOZ A;  1AU0 A;  4BS6 A;  5PAD A;  4YYS A;  1NB5 A;  3TMP A;  2E01 A;  4PI3 A;  2AU1 A;  4WA6 A;  3O65 A;  2HH5 A;  2F7D A;  2HD5 A;  2XU1 A;  1CPJ A;  2FQ9 A;  3K24 A;  3S3Q A;  1GEC E;  1XKG A;  2ATO A;  5CVN B;  1YVB A;  3HHI A;  1Y4H A;  4PAD A;  4PP1 A;  5JH3 A;  4MM3 B;  1PPO A;  3HHA A;  1UKF A;  1TL9 A;  4CDC B;  4FIP A;  2IPP B;  3MTN A;  3OF8 A;  3HD3 A;  3RVX A;  3PBH A;  2E03 A;  2DJG B;  4CDE B;  3W31 A;  4XR7 A;  2NQA A;  1KHQ A;  4I04 A;  3KWZ A;  2XU3 A;  1S4V A;  4QRX A;  3BC3 A;  2NQD B;  4Q8H A;  3BB7 A;  3RVW A;  5K16 A;  2ACT A;  4QBB A;  2BTW A;  2P86 A;  3RVV A;  1NPZ A;  2R9M A;  4IUM A;  2JRI A;  2Z84 A;  2AUZ A;  1PCI A;  3M99 A;  2WBF X;  1GMY A;  5JZE A;  2JQF R;  1EF7 A;  2AYO A;  4W5B A;  3U8E A;  1FH0 A;  3K8U A;  2BDL A;  4RF1 A;  1BGO A;  1KFU L;  4OEL A;  9PAP A;  2AVW A;  4X6J A;  1MDW A;  1Y08 A;  4XZX A;  2UZJ A;  4I05 A;  2AUX A;  2CIO A;  1AYW A;  3OVZ A;  2DCB A;  3NHE A;  1F2A A;  1BP4 A;  3LXS A;  2FRA A;  2R9F A;  1PPP A;  3V6C A;  3WXG A;  3PHX A;  4WUR A;  1YAL A;  4BS5 A;  3PHU A;  4N8W A;  2DJF B;  4BOU A;  3IUT A;  5CHV A;  2R9C A;  1CS8 A;  1YT7 A;  1U9V A;  7PCK A;  3H89 A;  4DMX A;  3KKU A;  4P6G A;  1GLO A;  1SP4 B;  2BTW B;  2ARY A;  2FTD A;  1DEU A;  4D8I A;  4BOS A;  1AU2 A;  1Q6K A;  1QXP A;  3ZUA A;  3MHH A;  3N3K A;  2R6N A;  3IEJ A;  4N79 A;  4YYR A;  2PRE A;  3E9S A;  3N4C A;  4QH6 A;  1YK7 A;  3BOW A;  4QRV A;  4W4U A;  1A6R A;  2XU4 A;  4BOP A;  1JQP A;  1ZCM A;  1AEC A;  3KFQ A;  2CB5 A;  1CB5 A;  2OZ2 A;  3B79 A;  4RF0 A;  3MP2 A;  4FJC A;  4BQV A;  2NQI A;  3P5U A;  1NL6 A;  1BQI A;  3F5V A;  2DOS A;  2DZZ A;  4MZS A;  1X9Y A;  2BU3 A;  2G6D A;  5KO3 A;  1DF0 A;  2OUL A;  4R3D A;  4MZO A;  1NQC A;  3OQC A;  2Y5B A;  1AYU A;  4CDD B;  1M6D A;  1ZIV A;  1YK8 A;  1F2B A;  3MHS A;  4CDF B;  3C9E A;  3H8B A;  2HWK A;  3KW9 A;  2B1N A;  1TLO A;  1AU3 A;  4HXD B;  2GHU A;  1CVZ A;  2FUD A;  2P7U A;  1STF E;  2YJ2 A;  4P6E A;  3TNX A;  2VHS A;  1PAD A;  3OIS A;  4AXL A;  3AI8 A;  3QT4 A;  4CZW A;  2BDZ A;  1QOL A;  2FO5 A;  2DC9 A;  4X6H A;  4HWY A;  2G8J A;  2H7J A;  2HXZ A;  3KWB X;  1U5I A;  1KXR A;  3OF9 A;  5J94 A;  8PCH A;  4OW0 A;  4RY2 A;  4W5C A;  3ERV A;  3PDF A;  1QDQ A;  2R9O A;  1DKI A;  2J7Q C;  3QJ3 A;  1CQD A;  4ZUX U;  1PVJ A;  3CH2 X;  1PPN A;  3IFU A;  1U9Q X;  3CH3 X;  5EZQ A;  2PBH A;  1VJV A;  1U9W A;  4N4Z A;  3P5W A;  1CSB B;  2DZY A;  3USV A;  1MHW A;  3BBA A;  5FPW A;  3E1Z B;  3IV2 A;  3PNR A;  1O0E A;  1PPD A;  3IMA A;  3O0U A;  4PT5 A;  3WXF A;  3F75 A;  5CVO B;  3BPM A;  4OVZ A;  3IOQ A;  1POP A;  2FT2 A;  4IP3 A;  4RNA A;  3I3T A;  3I06 A;  3MJ5 A;  2G8E A;  3KSE A;  4ZTB A;  4BOQ A;  2C0Y A;  4BPV A;  1CV8 A;  3PT2 A;  1VSN A;  3KX1 A;  2AS8 A;  5CVM A;  3CBK A;  2GFO A;  5EF4 A;  2R9N A;  1MEG A;  3B21 A;  3GCB A;  2F1G A;  1IWD A;  1F29 A;  4YYU A;  2DCD A;  1EWL A;  2P0R A;  1ITO A;  1SNK A;  4GUA A;  1AYV A;  3K9M A;  3PHW A;  5F02 A;  1PE6 A;  3LFY A;  3H7D A;  2G7Y A;  4K7C A;  1AU4 A;  2DC8 A;  1U9X A;  4XUI A;  2OP3 A;  1NLJ A;  3C0R A;  2E02 A;  3N3G A;  2DCA A;  1CJL A;  4P16 A;  4OVZ B;  3D6S A;  1EWM A;  2FE8 A;  2DC6 A;  2JQG R;  4X6I A;  3BPF A;  5A24 A;  1ME4 A;  2JTC A;  3PRP A;  1EWO A;  1K3B B;  2DCC A;  1MS6 A;  1CTE A;  5E6J A;  2YJ9 A;  4REZ A;  4DMY A;  4AXM A;  1KHP A;  3PSE A;  3DF0 A;  2FRQ A;  4D8B A;  2AIM A;  1AIM A;  1THE A;  3H6S A;  1PXV A;  3W30 A;  1F2C A;  3MTV A;  2XU5 A;  4FK5 A;  3V6E A;  4BSQ A;  4YYV A;  1QMY A;  3S3R A;  3PW3 A;  1ICF A;  4Q8G A;  5EZS A;  3O1G A;  1ATK A; 
#chains in the Genus database with same CATH homology
 2IBI A;  4KLB A;  1MIR A;  6PAD A;  5EGW A;  2VHF A;  3IHP A;  3CBJ A;  5JA7 A;  4QRG A;  3P5V A;  2YJB A;  4PP2 E;  1EWP A;  4MSX A;  1ME3 A;  1GCB A;  3OVX A;  2B1M A;  4YYW A;  2AYN A;  2NQG A;  1PBH A;  3BCN A;  3H8C A;  1HUC B;  3HWN A;  4G54 A;  2PAD A;  1KFX L;  1TU6 A;  3P5X A;  3MOR A;  2O6X A;  2HHN A;  4I07 A;  4YYQ A;  1NB3 A;  3BWK A;  2FYE A;  4OEM A;  3QSD A;  1BY8 A;  4YVA A;  1PIP A;  5CHT A;  1MEM A;  2E00 A;  2Y6E A;  3WXE A;  4YV8 A;  2DC7 A;  2PNS A;  2YJ8 A;  2YJC A;  1AU0 A;  4BS6 A;  5PAD A;  4YYS A;  1NB5 A;  2E01 A;  4PI3 A;  2AU1 A;  4WA6 A;  2HH5 A;  2F7D A;  2HD5 A;  2XU1 A;  1CPJ A;  2FQ9 A;  3K24 A;  3S3Q A;  1GEC E;  1XKG A;  2ATO A;  5CVN B;  1YVB A;  3HHI A;  1Y4H A;  4PAD A;  4PP1 A;  5JH3 A;  1PPO A;  3HHA A;  4B55 A;  1TL9 A;  4CDC B;  4FIP A;  2IPP B;  3MTN A;  3OF8 A;  3HD3 A;  4NV8 A;  3PBH A;  3RVX A;  2E03 A;  2DJG B;  4CDE B;  4XR7 A;  2BSZ A;  2NQA A;  1KHQ A;  4I04 A;  3KWZ A;  2XU3 A;  1S4V A;  4QRX A;  3BC3 A;  2NQD B;  4Q8H A;  3RVW A;  5K16 A;  2ACT A;  4QBB A;  2P86 A;  3RVV A;  1NPZ A;  2R9M A;  2AUZ A;  1PCI A;  3M99 A;  2WBF X;  1GMY A;  2JQF R;  1EF7 A;  2AYO A;  4W5B A;  3U8E A;  1FH0 A;  3K8U A;  2BDL A;  1BGO A;  1KFU L;  4OEL A;  9PAP A;  2AVW A;  4X6J A;  1MDW A;  1Y08 A;  4I05 A;  2AUX A;  2CIO A;  1AYW A;  3OVZ A;  2DCB A;  3NHE A;  1F2A A;  1BP4 A;  3LXS A;  2FRA A;  2R9F A;  1PPP A;  3V6C A;  3WXG A;  1YAL A;  4BS5 A;  2VFB A;  4N8W A;  2DJF B;  3IUT A;  5CHV A;  2R9C A;  1CS8 A;  1YT7 A;  1U9V A;  7PCK A;  3H89 A;  4DMX A;  3KKU A;  4P6G A;  1GLO A;  1SP4 B;  2ARY A;  2FTD A;  1DEU A;  1W5R A;  4NV7 A;  1AU2 A;  1Q6K A;  1QXP A;  3ZUA A;  3MHH A;  3N3K A;  2R6N A;  3IEJ A;  4N79 A;  4YYR A;  2PRE A;  3N4C A;  4BGF A;  4QH6 A;  3D9W A;  1YK7 A;  3BOW A;  4QRV A;  4W4U A;  1A6R A;  2XU4 A;  1JQP A;  1ZCM A;  1AEC A;  3KFQ A;  2CB5 A;  4GUZ A;  1CB5 A;  2OZ2 A;  3B79 A;  4FJC A;  4BQV A;  2NQI A;  3P5U A;  1GX3 A;  1NL6 A;  1BQI A;  3F5V A;  2DZZ A;  4MZS A;  1X9Y A;  2G6D A;  1DF0 A;  2OUL A;  4MZO A;  1NQC A;  2Y5B A;  1AYU A;  4CDD B;  1M6D A;  1ZIV A;  1YK8 A;  1F2B A;  3MHS A;  4CDF B;  3C9E A;  3H8B A;  3KW9 A;  2B1N A;  1TLO A;  1AU3 A;  2GHU A;  1CVZ A;  2FUD A;  2P7U A;  1STF E;  2YJ2 A;  4P6E A;  3TNX A;  2VHS A;  1PAD A;  3OIS A;  4AXL A;  3AI8 A;  3QT4 A;  4CZW A;  2BDZ A;  1QOL A;  2FO5 A;  2DC9 A;  4X6H A;  4HWY A;  2G8J A;  2H7J A;  2HXZ A;  3KWB X;  1U5I A;  1KXR A;  3OF9 A;  5J94 A;  8PCH A;  4RY2 A;  4W5C A;  3ERV A;  3PDF A;  1QDQ A;  2R9O A;  3QJ3 A;  1CQD A;  4ZUX U;  3CH2 X;  1PPN A;  1U9Q X;  3CH3 X;  2PBH A;  1VJV A;  1U9W A;  1W6F A;  4N4Z A;  3P5W A;  1CSB B;  2DZY A;  3USV A;  1MHW A;  5FPW A;  3E1Z B;  3IV2 A;  3PNR A;  1O0E A;  1PPD A;  3IMA A;  3O0U A;  3WXF A;  3F75 A;  5CVO B;  3BPM A;  3IOQ A;  1POP A;  2FT2 A;  3I3T A;  3I06 A;  2G8E A;  3KSE A;  2C0Y A;  4BPV A;  1CV8 A;  1VSN A;  3KX1 A;  2AS8 A;  5CVM A;  3CBK A;  2GFO A;  5EF4 A;  2R9N A;  1MEG A;  3GCB A;  2F1G A;  1IWD A;  1F29 A;  4YYU A;  2DCD A;  1EWL A;  2P0R A;  1ITO A;  1SNK A;  1AYV A;  3K9M A;  5F02 A;  1PE6 A;  3LFY A;  3H7D A;  2G7Y A;  3LTW A;  4K7C A;  1AU4 A;  2DC8 A;  1U9X A;  4XUI A;  2OP3 A;  1NLJ A;  2E02 A;  3N3G A;  2DCA A;  1CJL A;  3D6S A;  1EWM A;  2DC6 A;  2JQG R;  4X6I A;  3BPF A;  5A24 A;  1ME4 A;  1EWO A;  1K3B B;  2DCC A;  1MS6 A;  1CTE A;  2VFC A;  2YJ9 A;  4DMY A;  4AXM A;  1W4T A;  1E2T A;  1KHP A;  3DF0 A;  2FRQ A;  2AIM A;  1AIM A;  1THE A;  3H6S A;  1PXV A;  1F2C A;  2XU5 A;  4FK5 A;  3V6E A;  4BSQ A;  4C5P A;  4YYV A;  1QMY A;  3S3R A;  3PW3 A;  1ICF A;  4Q8G A;  3O1G A;  1ATK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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