2G8JA

Calpain 1 proteolytic core in complex with snj-1945, a alpha-ketoamide-type inhibitor.
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
322
structure length
322
Chain Sequence
NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography
pubmed doi rcsb
source organism Rattus norvegicus
molecule tags Hydrolase
molecule keywords Calpain-1 catalytic subunit
total genus 100
structure length 322
sequence length 322
ec nomenclature ec 3.4.22.52: Calpain-1.
pdb deposition date 2006-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00648 Peptidase_C2 Calpain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 2g8jA02
7PCKA 4QRXA 1TLOA 1NPZA 1GMYA 2DC9A 2PADA 2DCCA 2F7DA 1PPDA 2F1GA 4BQVA 1POPA 1BGOA 1NQCA 2AVWA 2Y6EA 4AXLA 1CV8A 3BWKA 2JQFR 1KFUL 1M6DA 3H6SA 3OVZA 2PNSA 3HHAA 2AUZA 2YJ9A 1SNKA 3KFQA 3U8EA 3OISA 1CPJA 4MZOA 4RY2A 3H8BA 4XUIA 1QMYA 1YK7A 3F75A 5F02A 4PP1A 6PADA 4FJCA 4K7CA 3NHEA 1PPPA 1ATKA 3V6CA 1MDWA 4KLBA 1AIMA 2E02A 1GECE 3K8UA 1AU2A 2NQIA 2CIOA 1ME4A 4PP2E 3TNXA 4FIPA 1BY8A 4MSXA 2GFOA 3HD3A 1PPNA 4FK5A 3C9EA 1MHWA 4BS5A 2ARYA 2AYOA 3IMAA 3MHSA 2P0RA 1GLOA 1PCIA 1PBHA 2YJCA 2R6NA 2FTDA 3K9MA 3WXEA 8PCHA 2B1MA 2PREA 1U9XA 5FPWA 2R9FA 2AYNA 2AU1A 3H8CA 2WBFX 3E1ZB 3ERVA 1THEA 2HXZA 5A24A 4YYUA 4Q8GA 2H7JA 3HHIA 2YJ2A 3PW3A 3USVA 3IEJA 4W5BA 1K3BB 3WXGA 3P5WA 5CHVA 4HWYA 1QOLA 3N3KA 1JQPA 4QRGA 1KFXL 1X9YA 2YJ8A 1AU3A 1CQDA 2DC8A 4I04A 2P7UA 3RVWA 3OVXA 2R9NA 2Y5BA 2R9MA 3P5XA 1CSBB 4QRVA 3KX1A 3BOWA 4CZWA 2BDZA 5EGWA 4BSQA 2OP3A 5J94A 1BP4A 2ACTA 2BDLA 3WXFA 1BQIA 1F2CA 3CBJA 4QH6A 3MHHA 3CH3X 4P6EA 2XU4A 1MIRA 5CVMA 1XKGA 2XU5A 3P5UA 3M99A 3KW9A 1U5IA 2AS8A 5JA7A 4I05A 2DJFB 1U9WA 1U9VA 3IHPA 4OEMA 4PI3A 1VSNA 4YV8A 3LFYA 3CBKA 3IOQA 1HUCB 3DF0A 2NQGA 1KHQA 2ATOA 1YALA 2IBIA 4AXMA 1GCBA 1ZCMA 4DMYA 3PBHA 4I07A 5CVNB 1AYWA 1ICFA 3I3TA 4ZUXU 1AYVA 1NL6A 1CJLA 9PAPA 1FH0A 1MS6A 2G8JA 2XU3A 4X6IA 1PPOA 3QJ3A 4XR7A 1NB3A 3PDFA 1PXVA 2C0YA 2G6DA 3I06A 1YT7A 3V6EA 4PADA 1TU6A 4WA6A 5CHTA 2DC7A 3PNRA 1DEUA 2FO5A 2NQDB 1PIPA 3BC3A 4BS6A 5K16A 3KKUA 4MZSA 3RVVA 1MEGA 2DJGB 1Q6KA 1ZIVA 2E00A 3N3GA 1PADA 3O1GA 5JH3A 3QSDA 4Q8HA 1S4VA 1CVZA 1EWPA 2JQGR 4X6JA 2YJBA 1ITOA 2IPPB 4YYSA 1A6RA 2DZZA 2DCDA 2OZ2A 3KSEA 2DCBA 2FT2A 4N4ZA 1DF0A 2DCAA 4YYVA 3N4CA 1VJVA 3S3RA 2G8EA 2HD5A 1KHPA 2HH5A 3BPFA 1F29A 3OF8A 2PBHA 1AECA 1F2BA 1IWDA 1SP4B 4CDFB 1O0EA 3AI8A 1NLJA 3KWZA 3H89A 1EWLA 2E03A 1QDQA 4CDEB 2HHNA 3MORA 4YVAA 3MTNA 3BCNA 1U9QX 3OF9A 5PADA 4BPVA 4W5CA 2FYEA 1TL9A 4YYRA 1YVBA 2G7YA 2FUDA 2O6XA 1Y08A 2R9CA 2P86A 3P5VA 1AYUA 3GCBA 1EWOA 3S3QA 2XU1A 4DMXA 2CB5A 4P6GA 1NB5A 3IUTA 4W4UA 1ME3A 2DZYA 3D6SA 4OELA 1EWMA 1CB5A 3B79A 4YYWA 5CVOB 1QXPA 2VHSA 4CDDB 1AU4A 3LXSA 2FRAA 2NQAA 2FRQA 3HWNA 4N8WA 1STFE 3ZUAA 3RVXA 2FQ9A 5EF4A 3O0UA 1CTEA 2VHFA 4G54A 3CH2X 2AIMA 3QT4A 2E01A 2R9OA 3KWBX 2DC6A 4N79A 4CDCB 1PE6A 1KXRA 1EF7A 3F5VA 4X6HA 2AUXA 1CS8A 2B1NA 2GHUA 1MEMA 2OULA 4QBBA 1Y4HA 1F2AA 4YYQA 3H7DA 3IV2A 3K24A 1AU0A 1YK8A 3BPMA
chains in the Genus database with same CATH superfamily
7PCKA 4QRXA 1TLOA 1NPZA 1GMYA 2DC9A 2PADA 2DCCA 2F7DA 1PPDA 2F1GA 4BQVA 1POPA 1BGOA 1NQCA 2AVWA 2Y6EA 4AXLA 4D8EA 1CV8A 4MI7A 4BOPA 3BWKA 2JQFR 1KFUL 1M6DA 3H6SA 3OVZA 2PNSA 3HHAA 2AUZA 2YJ9A 4M0WA 1SNKA 3KFQA 3U8EA 2J7QA 3OISA 4RNAA 1CPJA 4MZOA 4RY2A 3H8BA 4XUIA 1QMYA 1YK7A 3F75A 4XZXA 5F02A 4PP1A 3RNVA 6PADA 4FJCA 4HXDB 4K7CA 3B21A 3NHEA 1PPPA 1ATKA 5KO3A 4D8IA 3V6CA 4KLBA 1MDWA 1AIMA 2E02A 1GECE 3K8UA 1AU2A 2NQIA 4RF0A 2CIOA 1ME4A 4PP2E 3TNXA 4FIPA 2JTCA 2BTWA 1BY8A 4MSXA 2GFOA 3HD3A 1PPNA 4FK5A 3C9EA 1MHWA 4BS5A 2ARYA 2AYOA 3IMAA 3MHSA 2P0RA 1GLOA 4MM3B 1PCIA 4BOZA 1PBHA 2YJCA 2R6NA 2FTDA 3BB7A 3K9MA 4OW0A 3WXEA 8PCHA 2B1MA 2PREA 1U9XA 4ZTBA 5FPWA 2R9FA 2AYNA 2AU1A 4RF1A 3H8CA 2WBFX 3E1ZB 2Z84A 2AGAA 3ERVA 1THEA 2HXZA 5A24A 4YYUA 4Q8GA 2H7JA 4PT5A 3HHIA 2YJ2A 3PW3A 3USVA 3IEJA 4W5BA 1K3BB 3WXGA 3P5WA 5CHVA 4HWYA 1QOLA 4WURA 4IUMA 3N3KA 5JZEA 1JQPA 4QRGA 1KFXL 5EZQA 3PHXA 1X9YA 5E6JA 2YJ8A 1AU3A 1CQDA 2DC8A 4I04A 2P7UA 3RVWA 3OVXA 2R9NA 2Y5BA 2R9MA 2J7QC 3P5XA 1CSBB 4QRVA 3KX1A 1DKIA 3PRPA 3BOWA 4CZWA 2BDZA 5EGWA 4BSQA 2OP3A 1UKFA 5J94A 1BP4A 2ACTA 2BDLA 2JRIA 3WXFA 1BQIA 1F2CA 3CBJA 4QH6A 3MHHA 3CH3X 4P6EA 2XU4A 4BOSA 1MIRA 5CVMA 1XKGA 2XU5A 3P5UA 3M99A 3KW9A 1U5IA 2AS8A 5JA7A 4I05A 2DJFB 1U9WA 1U9VA 3IHPA 4OEMA 4PI3A 4OVZB 1VSNA 4YV8A 3LFYA 3CBKA 3IOQA 1HUCB 3DF0A 3PT2A 3BBAA 2NQGA 2DOSA 1KHQA 2ATOA 1YALA 2IBIA 4AXMA 1GCBA 1ZCMA 4DMYA 3PBHA 4D8BA 4I07A 5CVNB 1AYWA 1ICFA 3I3TA 4ZUXU 1AYVA 1NL6A 1CJLA 3TRKA 9PAPA 1FH0A 1MS6A 2G8JA 2XU3A 4X6IA 1PPOA 3E9SA 3QJ3A 3BY4A 4XR7A 1NB3A 5EZSA 3PDFA 1PXVA 2C0YA 2G6DA 3I06A 1YT7A 3V6EA 4PADA 1TU6A 4WA6A 3PHWA 5CHTA 2DC7A 3PNRA 1DEUA 2FO5A 2NQDB 1PIPA 3BC3A 4BS6A 5K16A 4GUAA 3KKUA 4MZSA 4R3DA 3RVVA 1MEGA 3IFUA 2DJGB 1Q6KA 2BTWB 1ZIVA 2E00A 3N3GA 1PADA 3O1GA 5JH3A 3QSDA 4Q8HA 1S4VA 1CVZA 2FE8A 1EWPA 2JQGR 4X6JA 2YJBA 3MTVA 1ITOA 2IPPB 4YYSA 1A6RA 2DZZA 4RKXA 2DCDA 2OZ2A 3KSEA 2DCBA 2FT2A 4REZA 4N4ZA 2HWKA 3ZNHA 1DF0A 2DCAA 4YYVA 3N4CA 1VJVA 3S3RA 2G8EA 2HD5A 1KHPA 3PSEA 2HH5A 3BPFA 1YZBA 1F29A 3OF8A 2PBHA 1AECA 1F2BA 1IWDA 1SP4B 4CDFB 3C0RA 1O0EA 3W31A 3AI8A 1NLJA 3KWZA 3H89A 1EWLA 2E03A 1QDQA 4CDEB 4BOQA 2UZJA 2HHNA 3MORA 4YVAA 3MTNA 3BCNA 1U9QX 4OVZA 3OF9A 5PADA 4BPVA 4W5CA 2FYEA 1TL9A 4YYRA 1YVBA 2G7YA 2FUDA 2O6XA 4BOUA 1Y08A 2R9CA 2P86A 3P5VA 4IP3A 1AYUA 3GCBA 1EWOA 3PHUA 3S3QA 2XU1A 4DMXA 2CB5A 4P6GA 1NB5A 3IUTA 3O65A 4W4UA 1ME3A 2DZYA 3D6SA 3OQCA 1EWMA 4OELA 1CB5A 3B79A 3W30A 4YYWA 5CVOB 1QXPA 2VHSA 4CDDB 1AU4A 3MJ5A 3LXSA 4P16A 2FRAA 2NQAA 3MP2A 2FRQA 3HWNA 4N8WA 1STFE 3ZUAA 3RVXA 2FQ9A 5EF4A 3PRMA 3O0UA 1CTEA 2VHFA 4G54A 3CH2X 2AIMA 3QT4A 2E01A 2R9OA 4A5UA 3KWBX 2DC6A 1PVJA 4N79A 4CDCB 1PE6A 1KXRA 1EF7A 3F5VA 4X6HA 2AUXA 1CS8A 2BU3A 2B1NA 2GHUA 1MEMA 3TMPA 2OULA 4QBBA 1Y4HA 1F2AA 4YYQA 3H7DA 3IV2A 3K24A 1AU0A 1YK8A 3BPMA
chains in the Genus database with same CATH topology
7PCKA 4QRXA 1TLOA 1NPZA 1GMYA 2DC9A 2PADA 2DCCA 2F7DA 1PPDA 2F1GA 4BQVA 1POPA 1BGOA 1NQCA 2AVWA 2Y6EA 4AXLA 1CV8A 3BWKA 2JQFR 1KFUL 1M6DA 3H6SA 3OVZA 2PNSA 3HHAA 2AUZA 2YJ9A 4NV7A 1SNKA 3KFQA 3U8EA 3OISA 1CPJA 4MZOA 4RY2A 1GX3A 3H8BA 4XUIA 1QMYA 1W6FA 1YK7A 3F75A 5F02A 4PP1A 6PADA 4FJCA 4K7CA 3NHEA 1PPPA 1ATKA 3V6CA 1MDWA 4KLBA 1AIMA 2E02A 1GECE 3K8UA 4GUZA 1AU2A 2NQIA 2VFBA 2CIOA 2VFCA 1ME4A 4PP2E 3TNXA 4FIPA 1BY8A 4MSXA 2GFOA 3HD3A 1PPNA 4FK5A 3C9EA 1MHWA 4BS5A 2ARYA 2AYOA 3IMAA 3MHSA 2P0RA 1GLOA 1PCIA 1PBHA 2YJCA 2R6NA 2FTDA 3K9MA 3WXEA 8PCHA 2B1MA 2PREA 1U9XA 5FPWA 2R9FA 2AYNA 2AU1A 3H8CA 2WBFX 3E1ZB 3ERVA 1THEA 2HXZA 5A24A 4YYUA 4Q8GA 2H7JA 3HHIA 2YJ2A 3PW3A 3USVA 3IEJA 4W5BA 1K3BB 3WXGA 3P5WA 5CHVA 4HWYA 1QOLA 3N3KA 1JQPA 4QRGA 1KFXL 1X9YA 2YJ8A 1AU3A 1CQDA 2DC8A 4I04A 2P7UA 3RVWA 3OVXA 2R9NA 2Y5BA 2R9MA 3P5XA 1CSBB 4QRVA 3KX1A 3BOWA 4CZWA 2BDZA 5EGWA 4BSQA 2OP3A 5J94A 1BP4A 2ACTA 2BDLA 3WXFA 1BQIA 1F2CA 3CBJA 4QH6A 3MHHA 3CH3X 4P6EA 2XU4A 3D9WA 1MIRA 5CVMA 1XKGA 2XU5A 3P5UA 3M99A 3KW9A 1U5IA 2AS8A 5JA7A 4I05A 2DJFB 1U9WA 1U9VA 3IHPA 4OEMA 4PI3A 1VSNA 4YV8A 3LFYA 3CBKA 3IOQA 1HUCB 3DF0A 2NQGA 1KHQA 2ATOA 1YALA 2IBIA 1E2TA 1GCBA 1ZCMA 4AXMA 4DMYA 3PBHA 4NV8A 4I07A 5CVNB 1AYWA 1ICFA 3I3TA 4ZUXU 1AYVA 1NL6A 1CJLA 9PAPA 1FH0A 1MS6A 2G8JA 2XU3A 4X6IA 1PPOA 3QJ3A 4XR7A 1NB3A 3PDFA 1PXVA 2C0YA 2G6DA 3I06A 1YT7A 3V6EA 4PADA 1TU6A 4WA6A 5CHTA 2DC7A 3PNRA 1DEUA 2FO5A 2NQDB 1PIPA 3BC3A 4BS6A 5K16A 3KKUA 4MZSA 3RVVA 1MEGA 2DJGB 1Q6KA 2BSZA 1ZIVA 2E00A 3N3GA 1PADA 3O1GA 5JH3A 3QSDA 4Q8HA 1S4VA 1CVZA 1EWPA 2JQGR 4X6JA 2YJBA 1ITOA 2IPPB 4YYSA 1A6RA 2DZZA 2DCDA 2OZ2A 3KSEA 2DCBA 2FT2A 4N4ZA 1DF0A 2DCAA 4YYVA 3N4CA 1VJVA 3S3RA 2G8EA 2HD5A 1KHPA 2HH5A 3BPFA 1F29A 3OF8A 2PBHA 1AECA 1F2BA 1IWDA 1SP4B 4CDFB 1O0EA 3AI8A 1NLJA 3KWZA 3H89A 1EWLA 2E03A 1QDQA 4CDEB 2HHNA 3MORA 4YVAA 3MTNA 3BCNA 1U9QX 3OF9A 5PADA 4BPVA 4W5CA 2FYEA 1TL9A 4YYRA 1YVBA 2G7YA 2FUDA 2O6XA 1Y08A 2R9CA 2P86A 3P5VA 1AYUA 3GCBA 1EWOA 3S3QA 2XU1A 4DMXA 2CB5A 4P6GA 1W5RA 1NB5A 3IUTA 4W4UA 4C5PA 1ME3A 2DZYA 3D6SA 4OELA 1EWMA 1CB5A 3B79A 4YYWA 5CVOB 1QXPA 2VHSA 4CDDB 1AU4A 3LTWA 3LXSA 2FRAA 2NQAA 2FRQA 3HWNA 4N8WA 1STFE 3ZUAA 3RVXA 2FQ9A 5EF4A 3O0UA 1CTEA 2VHFA 4G54A 3CH2X 4B55A 2AIMA 3QT4A 2E01A 2R9OA 3KWBX 2DC6A 4N79A 4CDCB 1PE6A 1KXRA 1EF7A 3F5VA 4BGFA 4X6HA 2AUXA 1CS8A 2B1NA 2GHUA 1MEMA 2OULA 4QBBA 1Y4HA 1F2AA 4YYQA 3H7DA 3IV2A 3K24A 1W4TA 1AU0A 1YK8A 3BPMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 7PCK A;  4QRX A;  1TLO A;  1NPZ A;  1GMY A;  2DC9 A;  2PAD A;  2DCC A;  2F7D A;  1PPD A;  2F1G A;  4BQV A;  1POP A;  1BGO A;  1NQC A;  2AVW A;  2Y6E A;  4AXL A;  1CV8 A;  3BWK A;  2JQF R;  1KFU L;  1M6D A;  3H6S A;  3OVZ A;  2PNS A;  3HHA A;  2AUZ A;  2YJ9 A;  1SNK A;  3KFQ A;  3U8E A;  3OIS A;  1CPJ A;  4MZO A;  4RY2 A;  3H8B A;  4XUI A;  1QMY A;  1YK7 A;  3F75 A;  5F02 A;  4PP1 A;  6PAD A;  4FJC A;  4K7C A;  3NHE A;  1PPP A;  1ATK A;  3V6C A;  1MDW A;  4KLB A;  1AIM A;  2E02 A;  1GEC E;  3K8U A;  1AU2 A;  2NQI A;  2CIO A;  1ME4 A;  4PP2 E;  3TNX A;  4FIP A;  1BY8 A;  4MSX A;  2GFO A;  3HD3 A;  1PPN A;  4FK5 A;  3C9E A;  1MHW A;  4BS5 A;  2ARY A;  2AYO A;  3IMA A;  3MHS A;  2P0R A;  1GLO A;  1PCI A;  1PBH A;  2YJC A;  2R6N A;  2FTD A;  3K9M A;  3WXE A;  8PCH A;  2B1M A;  2PRE A;  1U9X A;  5FPW A;  2R9F A;  2AYN A;  2AU1 A;  3H8C A;  2WBF X;  3E1Z B;  3ERV A;  1THE A;  2HXZ A;  5A24 A;  4YYU A;  4Q8G A;  2H7J A;  3HHI A;  2YJ2 A;  3PW3 A;  3USV A;  3IEJ A;  4W5B A;  1K3B B;  3WXG A;  3P5W A;  5CHV A;  4HWY A;  1QOL A;  3N3K A;  1JQP A;  4QRG A;  1KFX L;  1X9Y A;  2YJ8 A;  1AU3 A;  1CQD A;  2DC8 A;  4I04 A;  2P7U A;  3RVW A;  3OVX A;  2R9N A;  2Y5B A;  2R9M A;  3P5X A;  1CSB B;  4QRV A;  3KX1 A;  3BOW A;  4CZW A;  2BDZ A;  5EGW A;  4BSQ A;  2OP3 A;  5J94 A;  1BP4 A;  2ACT A;  2BDL A;  3WXF A;  1BQI A;  1F2C A;  3CBJ A;  4QH6 A;  3MHH A;  3CH3 X;  4P6E A;  2XU4 A;  1MIR A;  5CVM A;  1XKG A;  2XU5 A;  3P5U A;  3M99 A;  3KW9 A;  1U5I A;  2AS8 A;  5JA7 A;  4I05 A;  2DJF B;  1U9W A;  1U9V A;  3IHP A;  4OEM A;  4PI3 A;  1VSN A;  4YV8 A;  3LFY A;  3CBK A;  3IOQ A;  1HUC B;  3DF0 A;  2NQG A;  1KHQ A;  2ATO A;  1YAL A;  2IBI A;  4AXM A;  1GCB A;  1ZCM A;  4DMY A;  3PBH A;  4I07 A;  5CVN B;  1AYW A;  1ICF A;  3I3T A;  4ZUX U;  1AYV A;  1NL6 A;  1CJL A;  9PAP A;  1FH0 A;  1MS6 A;  2G8J A;  2XU3 A;  4X6I A;  1PPO A;  3QJ3 A;  4XR7 A;  1NB3 A;  3PDF A;  1PXV A;  2C0Y A;  2G6D A;  3I06 A;  1YT7 A;  3V6E A;  4PAD A;  1TU6 A;  4WA6 A;  5CHT A;  2DC7 A;  3PNR A;  1DEU A;  2FO5 A;  2NQD B;  1PIP A;  3BC3 A;  4BS6 A;  5K16 A;  3KKU A;  4MZS A;  3RVV A;  1MEG A;  2DJG B;  1Q6K A;  1ZIV A;  2E00 A;  3N3G A;  1PAD A;  3O1G A;  5JH3 A;  3QSD A;  4Q8H A;  1S4V A;  1CVZ A;  1EWP A;  2JQG R;  4X6J A;  2YJB A;  1ITO A;  2IPP B;  4YYS A;  1A6R A;  2DZZ A;  2DCD A;  2OZ2 A;  3KSE A;  2DCB A;  2FT2 A;  4N4Z A;  1DF0 A;  2DCA A;  4YYV A;  3N4C A;  1VJV A;  3S3R A;  2G8E A;  2HD5 A;  1KHP A;  2HH5 A;  3BPF A;  1F29 A;  3OF8 A;  2PBH A;  1AEC A;  1F2B A;  1IWD A;  1SP4 B;  4CDF B;  1O0E A;  3AI8 A;  1NLJ A;  3KWZ A;  3H89 A;  1EWL A;  2E03 A;  1QDQ A;  4CDE B;  2HHN A;  3MOR A;  4YVA A;  3MTN A;  3BCN A;  1U9Q X;  3OF9 A;  5PAD A;  4BPV A;  4W5C A;  2FYE A;  1TL9 A;  4YYR A;  1YVB A;  2G7Y A;  2FUD A;  2O6X A;  1Y08 A;  2R9C A;  2P86 A;  3P5V A;  1AYU A;  3GCB A;  1EWO A;  3S3Q A;  2XU1 A;  4DMX A;  2CB5 A;  4P6G A;  1NB5 A;  3IUT A;  4W4U A;  1ME3 A;  2DZY A;  3D6S A;  4OEL A;  1EWM A;  1CB5 A;  3B79 A;  4YYW A;  5CVO B;  1QXP A;  2VHS A;  4CDD B;  1AU4 A;  3LXS A;  2FRA A;  2NQA A;  2FRQ A;  3HWN A;  4N8W A;  1STF E;  3ZUA A;  3RVX A;  2FQ9 A;  5EF4 A;  3O0U A;  1CTE A;  2VHF A;  4G54 A;  3CH2 X;  2AIM A;  3QT4 A;  2E01 A;  2R9O A;  3KWB X;  2DC6 A;  4N79 A;  4CDC B;  1PE6 A;  1KXR A;  1EF7 A;  3F5V A;  4X6H A;  2AUX A;  1CS8 A;  2B1N A;  2GHU A;  1MEM A;  2OUL A;  4QBB A;  1Y4H A;  1F2A A;  4YYQ A;  3H7D A;  3IV2 A;  3K24 A;  1AU0 A;  1YK8 A;  3BPM A; 
#chains in the Genus database with same CATH topology
 7PCK A;  4QRX A;  1TLO A;  1NPZ A;  1GMY A;  2DC9 A;  2PAD A;  2DCC A;  2F7D A;  1PPD A;  2F1G A;  4BQV A;  1POP A;  1BGO A;  1NQC A;  2AVW A;  2Y6E A;  4AXL A;  4D8E A;  1CV8 A;  4MI7 A;  4BOP A;  3BWK A;  2JQF R;  1KFU L;  1M6D A;  3H6S A;  3OVZ A;  2PNS A;  3HHA A;  2AUZ A;  2YJ9 A;  4M0W A;  1SNK A;  3KFQ A;  3U8E A;  2J7Q A;  3OIS A;  4RNA A;  1CPJ A;  4MZO A;  4RY2 A;  3H8B A;  4XUI A;  1QMY A;  1YK7 A;  3F75 A;  4XZX A;  5F02 A;  4PP1 A;  3RNV A;  6PAD A;  4FJC A;  4HXD B;  4K7C A;  3B21 A;  3NHE A;  1PPP A;  1ATK A;  5KO3 A;  4D8I A;  3V6C A;  4KLB A;  1MDW A;  1AIM A;  2E02 A;  1GEC E;  3K8U A;  1AU2 A;  2NQI A;  4RF0 A;  2CIO A;  1ME4 A;  4PP2 E;  3TNX A;  4FIP A;  2JTC A;  2BTW A;  1BY8 A;  4MSX A;  2GFO A;  3HD3 A;  1PPN A;  4FK5 A;  3C9E A;  1MHW A;  4BS5 A;  2ARY A;  2AYO A;  3IMA A;  3MHS A;  2P0R A;  1GLO A;  4MM3 B;  1PCI A;  4BOZ A;  1PBH A;  2YJC A;  2R6N A;  2FTD A;  3BB7 A;  3K9M A;  4OW0 A;  3WXE A;  8PCH A;  2B1M A;  2PRE A;  1U9X A;  4ZTB A;  5FPW A;  2R9F A;  2AYN A;  2AU1 A;  4RF1 A;  3H8C A;  2WBF X;  3E1Z B;  2Z84 A;  2AGA A;  3ERV A;  1THE A;  2HXZ A;  5A24 A;  4YYU A;  4Q8G A;  2H7J A;  4PT5 A;  3HHI A;  2YJ2 A;  3PW3 A;  3USV A;  3IEJ A;  4W5B A;  1K3B B;  3WXG A;  3P5W A;  5CHV A;  4HWY A;  1QOL A;  4WUR A;  4IUM A;  3N3K A;  5JZE A;  1JQP A;  4QRG A;  1KFX L;  5EZQ A;  3PHX A;  1X9Y A;  5E6J A;  2YJ8 A;  1AU3 A;  1CQD A;  2DC8 A;  4I04 A;  2P7U A;  3RVW A;  3OVX A;  2R9N A;  2Y5B A;  2R9M A;  2J7Q C;  3P5X A;  1CSB B;  4QRV A;  3KX1 A;  1DKI A;  3PRP A;  3BOW A;  4CZW A;  2BDZ A;  5EGW A;  4BSQ A;  2OP3 A;  1UKF A;  5J94 A;  1BP4 A;  2ACT A;  2BDL A;  2JRI A;  3WXF A;  1BQI A;  1F2C A;  3CBJ A;  4QH6 A;  3MHH A;  3CH3 X;  4P6E A;  2XU4 A;  4BOS A;  1MIR A;  5CVM A;  1XKG A;  2XU5 A;  3P5U A;  3M99 A;  3KW9 A;  1U5I A;  2AS8 A;  5JA7 A;  4I05 A;  2DJF B;  1U9W A;  1U9V A;  3IHP A;  4OEM A;  4PI3 A;  4OVZ B;  1VSN A;  4YV8 A;  3LFY A;  3CBK A;  3IOQ A;  1HUC B;  3DF0 A;  3PT2 A;  3BBA A;  2NQG A;  2DOS A;  1KHQ A;  2ATO A;  1YAL A;  2IBI A;  4AXM A;  1GCB A;  1ZCM A;  4DMY A;  3PBH A;  4D8B A;  4I07 A;  5CVN B;  1AYW A;  1ICF A;  3I3T A;  4ZUX U;  1AYV A;  1NL6 A;  1CJL A;  3TRK A;  9PAP A;  1FH0 A;  1MS6 A;  2G8J A;  2XU3 A;  4X6I A;  1PPO A;  3E9S A;  3QJ3 A;  3BY4 A;  4XR7 A;  1NB3 A;  5EZS A;  3PDF A;  1PXV A;  2C0Y A;  2G6D A;  3I06 A;  1YT7 A;  3V6E A;  4PAD A;  1TU6 A;  4WA6 A;  3PHW A;  5CHT A;  2DC7 A;  3PNR A;  1DEU A;  2FO5 A;  2NQD B;  1PIP A;  3BC3 A;  4BS6 A;  5K16 A;  4GUA A;  3KKU A;  4MZS A;  4R3D A;  3RVV A;  1MEG A;  3IFU A;  2DJG B;  1Q6K A;  2BTW B;  1ZIV A;  2E00 A;  3N3G A;  1PAD A;  3O1G A;  5JH3 A;  3QSD A;  4Q8H A;  1S4V A;  1CVZ A;  2FE8 A;  1EWP A;  2JQG R;  4X6J A;  2YJB A;  3MTV A;  1ITO A;  2IPP B;  4YYS A;  1A6R A;  2DZZ A;  4RKX A;  2DCD A;  2OZ2 A;  3KSE A;  2DCB A;  2FT2 A;  4REZ A;  4N4Z A;  2HWK A;  3ZNH A;  1DF0 A;  2DCA A;  4YYV A;  3N4C A;  1VJV A;  3S3R A;  2G8E A;  2HD5 A;  1KHP A;  3PSE A;  2HH5 A;  3BPF A;  1YZB A;  1F29 A;  3OF8 A;  2PBH A;  1AEC A;  1F2B A;  1IWD A;  1SP4 B;  4CDF B;  3C0R A;  1O0E A;  3W31 A;  3AI8 A;  1NLJ A;  3KWZ A;  3H89 A;  1EWL A;  2E03 A;  1QDQ A;  4CDE B;  4BOQ A;  2UZJ A;  2HHN A;  3MOR A;  4YVA A;  3MTN A;  3BCN A;  1U9Q X;  4OVZ A;  3OF9 A;  5PAD A;  4BPV A;  4W5C A;  2FYE A;  1TL9 A;  4YYR A;  1YVB A;  2G7Y A;  2FUD A;  2O6X A;  4BOU A;  1Y08 A;  2R9C A;  2P86 A;  3P5V A;  4IP3 A;  1AYU A;  3GCB A;  1EWO A;  3PHU A;  3S3Q A;  2XU1 A;  4DMX A;  2CB5 A;  4P6G A;  1NB5 A;  3IUT A;  3O65 A;  4W4U A;  1ME3 A;  2DZY A;  3D6S A;  3OQC A;  1EWM A;  4OEL A;  1CB5 A;  3B79 A;  3W30 A;  4YYW A;  5CVO B;  1QXP A;  2VHS A;  4CDD B;  1AU4 A;  3MJ5 A;  3LXS A;  4P16 A;  2FRA A;  2NQA A;  3MP2 A;  2FRQ A;  3HWN A;  4N8W A;  1STF E;  3ZUA A;  3RVX A;  2FQ9 A;  5EF4 A;  3PRM A;  3O0U A;  1CTE A;  2VHF A;  4G54 A;  3CH2 X;  2AIM A;  3QT4 A;  2E01 A;  2R9O A;  4A5U A;  3KWB X;  2DC6 A;  1PVJ A;  4N79 A;  4CDC B;  1PE6 A;  1KXR A;  1EF7 A;  3F5V A;  4X6H A;  2AUX A;  1CS8 A;  2BU3 A;  2B1N A;  2GHU A;  1MEM A;  3TMP A;  2OUL A;  4QBB A;  1Y4H A;  1F2A A;  4YYQ A;  3H7D A;  3IV2 A;  3K24 A;  1AU0 A;  1YK8 A;  3BPM A; 
#chains in the Genus database with same CATH homology
 7PCK A;  4QRX A;  1TLO A;  1NPZ A;  1GMY A;  2DC9 A;  2PAD A;  2DCC A;  2F7D A;  1PPD A;  2F1G A;  4BQV A;  1POP A;  1BGO A;  1NQC A;  2AVW A;  2Y6E A;  4AXL A;  1CV8 A;  3BWK A;  2JQF R;  1KFU L;  1M6D A;  3H6S A;  3OVZ A;  2PNS A;  3HHA A;  2AUZ A;  2YJ9 A;  4NV7 A;  1SNK A;  3KFQ A;  3U8E A;  3OIS A;  1CPJ A;  4MZO A;  4RY2 A;  1GX3 A;  3H8B A;  4XUI A;  1QMY A;  1W6F A;  1YK7 A;  3F75 A;  5F02 A;  4PP1 A;  6PAD A;  4FJC A;  4K7C A;  3NHE A;  1PPP A;  1ATK A;  3V6C A;  1MDW A;  4KLB A;  1AIM A;  2E02 A;  1GEC E;  3K8U A;  4GUZ A;  1AU2 A;  2NQI A;  2VFB A;  2CIO A;  2VFC A;  1ME4 A;  4PP2 E;  3TNX A;  4FIP A;  1BY8 A;  4MSX A;  2GFO A;  3HD3 A;  1PPN A;  4FK5 A;  3C9E A;  1MHW A;  4BS5 A;  2ARY A;  2AYO A;  3IMA A;  3MHS A;  2P0R A;  1GLO A;  1PCI A;  1PBH A;  2YJC A;  2R6N A;  2FTD A;  3K9M A;  3WXE A;  8PCH A;  2B1M A;  2PRE A;  1U9X A;  5FPW A;  2R9F A;  2AYN A;  2AU1 A;  3H8C A;  2WBF X;  3E1Z B;  3ERV A;  1THE A;  2HXZ A;  5A24 A;  4YYU A;  4Q8G A;  2H7J A;  3HHI A;  2YJ2 A;  3PW3 A;  3USV A;  3IEJ A;  4W5B A;  1K3B B;  3WXG A;  3P5W A;  5CHV A;  4HWY A;  1QOL A;  3N3K A;  1JQP A;  4QRG A;  1KFX L;  1X9Y A;  2YJ8 A;  1AU3 A;  1CQD A;  2DC8 A;  4I04 A;  2P7U A;  3RVW A;  3OVX A;  2R9N A;  2Y5B A;  2R9M A;  3P5X A;  1CSB B;  4QRV A;  3KX1 A;  3BOW A;  4CZW A;  2BDZ A;  5EGW A;  4BSQ A;  2OP3 A;  5J94 A;  1BP4 A;  2ACT A;  2BDL A;  3WXF A;  1BQI A;  1F2C A;  3CBJ A;  4QH6 A;  3MHH A;  3CH3 X;  4P6E A;  2XU4 A;  3D9W A;  1MIR A;  5CVM A;  1XKG A;  2XU5 A;  3P5U A;  3M99 A;  3KW9 A;  1U5I A;  2AS8 A;  5JA7 A;  4I05 A;  2DJF B;  1U9W A;  1U9V A;  3IHP A;  4OEM A;  4PI3 A;  1VSN A;  4YV8 A;  3LFY A;  3CBK A;  3IOQ A;  1HUC B;  3DF0 A;  2NQG A;  1KHQ A;  2ATO A;  1YAL A;  2IBI A;  1E2T A;  1GCB A;  1ZCM A;  4AXM A;  4DMY A;  3PBH A;  4NV8 A;  4I07 A;  5CVN B;  1AYW A;  1ICF A;  3I3T A;  4ZUX U;  1AYV A;  1NL6 A;  1CJL A;  9PAP A;  1FH0 A;  1MS6 A;  2G8J A;  2XU3 A;  4X6I A;  1PPO A;  3QJ3 A;  4XR7 A;  1NB3 A;  3PDF A;  1PXV A;  2C0Y A;  2G6D A;  3I06 A;  1YT7 A;  3V6E A;  4PAD A;  1TU6 A;  4WA6 A;  5CHT A;  2DC7 A;  3PNR A;  1DEU A;  2FO5 A;  2NQD B;  1PIP A;  3BC3 A;  4BS6 A;  5K16 A;  3KKU A;  4MZS A;  3RVV A;  1MEG A;  2DJG B;  1Q6K A;  2BSZ A;  1ZIV A;  2E00 A;  3N3G A;  1PAD A;  3O1G A;  5JH3 A;  3QSD A;  4Q8H A;  1S4V A;  1CVZ A;  1EWP A;  2JQG R;  4X6J A;  2YJB A;  1ITO A;  2IPP B;  4YYS A;  1A6R A;  2DZZ A;  2DCD A;  2OZ2 A;  3KSE A;  2DCB A;  2FT2 A;  4N4Z A;  1DF0 A;  2DCA A;  4YYV A;  3N4C A;  1VJV A;  3S3R A;  2G8E A;  2HD5 A;  1KHP A;  2HH5 A;  3BPF A;  1F29 A;  3OF8 A;  2PBH A;  1AEC A;  1F2B A;  1IWD A;  1SP4 B;  4CDF B;  1O0E A;  3AI8 A;  1NLJ A;  3KWZ A;  3H89 A;  1EWL A;  2E03 A;  1QDQ A;  4CDE B;  2HHN A;  3MOR A;  4YVA A;  3MTN A;  3BCN A;  1U9Q X;  3OF9 A;  5PAD A;  4BPV A;  4W5C A;  2FYE A;  1TL9 A;  4YYR A;  1YVB A;  2G7Y A;  2FUD A;  2O6X A;  1Y08 A;  2R9C A;  2P86 A;  3P5V A;  1AYU A;  3GCB A;  1EWO A;  3S3Q A;  2XU1 A;  4DMX A;  2CB5 A;  4P6G A;  1W5R A;  1NB5 A;  3IUT A;  4W4U A;  4C5P A;  1ME3 A;  2DZY A;  3D6S A;  4OEL A;  1EWM A;  1CB5 A;  3B79 A;  4YYW A;  5CVO B;  1QXP A;  2VHS A;  4CDD B;  1AU4 A;  3LTW A;  3LXS A;  2FRA A;  2NQA A;  2FRQ A;  3HWN A;  4N8W A;  1STF E;  3ZUA A;  3RVX A;  2FQ9 A;  5EF4 A;  3O0U A;  1CTE A;  2VHF A;  4G54 A;  3CH2 X;  4B55 A;  2AIM A;  3QT4 A;  2E01 A;  2R9O A;  3KWB X;  2DC6 A;  4N79 A;  4CDC B;  1PE6 A;  1KXR A;  1EF7 A;  3F5V A;  4BGF A;  4X6H A;  2AUX A;  1CS8 A;  2B1N A;  2GHU A;  1MEM A;  2OUL A;  4QBB A;  1Y4H A;  1F2A A;  4YYQ A;  3H7D A;  3IV2 A;  3K24 A;  1W4T A;  1AU0 A;  1YK8 A;  3BPM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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