4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
2JTCA 3BBAA 4D8IA 1DKIA 4RKXA 3BB7A 2UZJA 4D8BA 1PVJA 4D8EA
chains in the Genus database with same CATH superfamily
1EWLA 3BY4A 1YK7A 1U9WA 1ZIVA 2WBFX 3OF9A 1MEMA 3MP2A 2R9FA 4MSXA 3HHAA 3K24A 2DCDA 4P16A 1YALA 3IEJA 2AVWA 5JA7A 3BOWA 2DJGB 3NHEA 2GFOA 2PNSA 2G8JA 3ZUAA 1ITOA 3H7DA 2JQFR 1QXPA 1EWPA 8PCHA 1DF0A 2FTDA 1PCIA 4W5CA 3GCBA 4P6GA 2HHNA 3KSEA 3P5VA 2P0RA 4DMYA 4ZUXU 1AECA 4BOQA 2AIMA 3RVXA 4M0WA 4OW0A 3ERVA 1QMYA 4YYRA 4PI3A 3W30A 1M6DA 4BOPA 2OP3A 1F2BA 4YYSA 3WXFA 1YK8A 1EF7A 1Q6KA 2BTWB 4W5BA 1YVBA 4AXLA 2YJ2A 4CZWA 4YYWA 2AS8A 2FO5A 1PPNA 2G8EA 2CIOA 4MZOA 1SP4B 5J94A 1F29A 3CBKA 2DC9A 1HUCB 1F2AA 5EGWA 1CTEA 2AGAA 3D6SA 3KFQA 3CH2X 1JQPA 2P7UA 3WXEA 3O1GA 5EF4A 5CHVA 1O0EA 3ZNHA 5KO3A 2DCBA 2ARYA 4CDDB 1IWDA 1CS8A 3IFUA 1AU2A 4G54A 2G6DA 3KW9A 1STFE 2IBIA 2HH5A 2DOSA 2YJCA 4RY2A 5EZQA 2G7YA 4X6IA 4I05A 3TMPA 3PDFA 4QRGA 5CHTA 2J7QC 2AUXA 3E9SA 3RVWA 4CDCB 1NQCA 3OQCA 2E00A 3AI8A 4BPVA 4BS6A 4X6JA 2VHFA 2J7QA 4X6HA 1PIPA 2JRIA 2AYNA 3KWBX 3QT4A 1ICFA 2Y6EA 3IUTA 3RVVA 2BDLA 3BB7A 3BPFA 3V6CA 1Y08A 1GLOA 2R6NA 4WURA 1ME3A 3U8EA 3H8BA 3B21A 4BOZA 1PE6A 3F5VA 2XU1A 9PAPA 3OVXA 1GECE 1U9QX 5PADA 2DC8A 3QJ3A 2JQGR 3H6SA 2NQDB 3CBJA 2AU1A 1AIMA 3C0RA 2DCCA 4HWYA 2DJFB 1K3BB 2B1MA 2JTCA 3BC3A 2HWKA 4PP2E 2GHUA 1YT7A 2R9CA 1MIRA 2BTWA 3P5XA 2F7DA 2B1NA 2UZJA 3C9EA 1S4VA 4GUAA 3S3QA 1EWMA 2OZ2A 2DC6A 1MDWA 1SNKA 3N3GA 1CJLA 4FIPA 3MORA 1THEA 6PADA 4BSQA 2DCAA 3MHSA 3PRMA 1NLJA 1X9YA 1PVJA 3I06A 3N4CA 4A5UA 5K16A 4QRVA 4BQVA 1U9XA 1AYWA 1PPOA 3PHWA 3MHHA 3V6EA 1GCBA 1PPPA 2YJ8A 3IOQA 4P6EA 4KLBA 1BQIA 2PADA 5CVMA 1UKFA 2PREA 5A24A 1KFXL 4MI7A 4CDEB 7PCKA 4PP1A 1CB5A 2ATOA 2IPPB 4I04A 2FE8A 1VJVA 1KFUL 5FPWA 1MEGA 2E01A 1TL9A 1AU3A 3M99A 1PXVA 1CSBB 4PADA 1BY8A 4Q8GA 3B79A 3BCNA 2FRAA 4QRXA 3USVA 5JH3A 4Q8HA 3HHIA 4R3DA 2HD5A 1MHWA 2DZZA 1NPZA 3DF0A 2AUZA 3LFYA 3KKUA 1GMYA 3OF8A 1POPA 1DEUA 2DC7A 4QBBA 4ZTBA 2XU4A 1ATKA 1KHQA 4XR7A 4REZA 3BBAA 4K7CA 4YV8A 2Y5BA 4OVZB 4RNAA 2XU5A 2PBHA 3H89A 2OULA 3W31A 2YJBA 1MS6A 3PBHA 3PRPA 3P5WA 1QOLA 1TLOA 3HWNA 4WA6A 4FJCA 3MJ5A 3CH3X 4RF0A 1CV8A 5JZEA 3HD3A 3S3RA 4RF1A 4RKXA 4XUIA 1KHPA 1AU0A 4D8BA 4AXMA 5E6JA 4HXDB 2ACTA 4DMXA 2E03A 1PBHA 1PPDA 3PT2A 2XU3A 2O6XA 1CVZA 3IMAA 4W4UA 3PNRA 1EWOA 1FH0A 4IP3A 3RNVA 4IUMA 3OVZA 3BPMA 1NB3A 3P5UA 3F75A 4BS5A 2F1GA 3PW3A 2AYOA 5CVOB 3IHPA 1NL6A 2R9NA 1BGOA 5CVNB 2R9MA 3O65A 1VSNA 3PSEA 1CPJA 3I3TA 2VHSA 3KWZA 4D8IA 1AYVA 3PHXA 1NB5A 4YYVA 3TNXA 2R9OA 2Z84A 2YJ9A 4MM3B 4N4ZA 2HXZA 3K8UA 1AU4A 4QH6A 1PADA 3PHUA 1BP4A 3E1ZB 4D8EA 2E02A 4FK5A 1TU6A 2BDZA 1Y4HA 3O0UA 4N8WA 2FYEA 4PT5A 1KXRA 3QSDA 3KX1A 4CDFB 2DZYA 2BU3A 4YYQA 2FQ9A 2NQAA 3WXGA 4OVZA 1F2CA 2FUDA 2C0YA 4MZSA 3BWKA 4YYUA 1QDQA 2FT2A 1DKIA 4N79A 3MTNA 2P86A 2FRQA 4BOSA 3TRKA 2CB5A 4BOUA 4XZXA 4OELA 4OEMA 2H7JA 1AYUA 5F02A 1U9VA 3N3KA 3K9MA 3OISA 1XKGA 1U5IA 3H8CA 1CQDA 2NQGA 4YVAA 2NQIA 1ZCMA 5EZSA 1ME4A 4I07A 3MTVA 3IV2A 3LXSA 1A6RA 1YZBA
chains in the Genus database with same CATH topology
3PHWA 3BY4A 2DOSA 3MP2A 5EZQA 1UKFA 3O65A 3PSEA 4P16A 3TMPA 4MI7A 2J7QC 3E9SA 4D8IA 2FE8A 3OQCA 3PHXA 2J7QA 2JRIA 2Z84A 3BB7A 4MM3B 4R3DA 4WURA 3PHUA 4D8EA 3B21A 4ZTBA 4BOZA 4BOQA 4PT5A 4REZA 4M0WA 3BBAA 4OW0A 3W30A 2BU3A 4BOPA 4OVZB 4RNAA 3C0RA 3W31A 4OVZA 3PRPA 2JTCA 2HWKA 1DKIA 2BTWB 3MJ5A 4BOSA 3TRKA 4RF0A 4BOUA 2BTWA 5JZEA 4XZXA 4RF1A 4RKXA 2UZJA 4D8BA 5E6JA 4GUAA 4HXDB 2AGAA 3PT2A 3PRMA 5EZSA 1PVJA 3MTVA 3ZNHA 5KO3A 4IP3A 4A5UA 3RNVA 4IUMA 3IFUA 1YZBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JTC A;  3BBA A;  4D8I A;  1DKI A;  4RKX A;  3BB7 A;  2UZJ A;  4D8B A;  1PVJ A;  4D8E A; 
#chains in the Genus database with same CATH topology
 1EWL A;  3BY4 A;  1YK7 A;  1U9W A;  1ZIV A;  2WBF X;  3OF9 A;  1MEM A;  3MP2 A;  2R9F A;  4MSX A;  3HHA A;  3K24 A;  2DCD A;  4P16 A;  1YAL A;  3IEJ A;  2AVW A;  5JA7 A;  3BOW A;  2DJG B;  3NHE A;  2GFO A;  2PNS A;  2G8J A;  3ZUA A;  1ITO A;  3H7D A;  2JQF R;  1QXP A;  1EWP A;  8PCH A;  1DF0 A;  2FTD A;  1PCI A;  4W5C A;  3GCB A;  4P6G A;  2HHN A;  3KSE A;  3P5V A;  2P0R A;  4DMY A;  4ZUX U;  1AEC A;  4BOQ A;  2AIM A;  3RVX A;  4M0W A;  4OW0 A;  3ERV A;  1QMY A;  4YYR A;  4PI3 A;  3W30 A;  1M6D A;  4BOP A;  2OP3 A;  1F2B A;  4YYS A;  3WXF A;  1YK8 A;  1EF7 A;  1Q6K A;  2BTW B;  4W5B A;  1YVB A;  4AXL A;  2YJ2 A;  4CZW A;  4YYW A;  2AS8 A;  2FO5 A;  1PPN A;  2G8E A;  2CIO A;  4MZO A;  1SP4 B;  5J94 A;  1F29 A;  3CBK A;  2DC9 A;  1HUC B;  1F2A A;  5EGW A;  1CTE A;  2AGA A;  3D6S A;  3KFQ A;  3CH2 X;  1JQP A;  2P7U A;  3WXE A;  3O1G A;  5EF4 A;  5CHV A;  1O0E A;  3ZNH A;  5KO3 A;  2DCB A;  2ARY A;  4CDD B;  1IWD A;  1CS8 A;  3IFU A;  1AU2 A;  4G54 A;  2G6D A;  3KW9 A;  1STF E;  2IBI A;  2HH5 A;  2DOS A;  2YJC A;  4RY2 A;  5EZQ A;  2G7Y A;  4X6I A;  4I05 A;  3TMP A;  3PDF A;  4QRG A;  5CHT A;  2J7Q C;  2AUX A;  3E9S A;  3RVW A;  4CDC B;  1NQC A;  3OQC A;  2E00 A;  3AI8 A;  4BPV A;  4BS6 A;  4X6J A;  2VHF A;  2J7Q A;  4X6H A;  1PIP A;  2JRI A;  2AYN A;  3KWB X;  3QT4 A;  1ICF A;  2Y6E A;  3IUT A;  3RVV A;  2BDL A;  3BB7 A;  3BPF A;  3V6C A;  1Y08 A;  1GLO A;  2R6N A;  4WUR A;  1ME3 A;  3U8E A;  3H8B A;  3B21 A;  4BOZ A;  1PE6 A;  3F5V A;  2XU1 A;  9PAP A;  3OVX A;  1GEC E;  1U9Q X;  5PAD A;  2DC8 A;  3QJ3 A;  2JQG R;  3H6S A;  2NQD B;  3CBJ A;  2AU1 A;  1AIM A;  3C0R A;  2DCC A;  4HWY A;  2DJF B;  1K3B B;  2B1M A;  2JTC A;  3BC3 A;  2HWK A;  4PP2 E;  2GHU A;  1YT7 A;  2R9C A;  1MIR A;  2BTW A;  3P5X A;  2F7D A;  2B1N A;  2UZJ A;  3C9E A;  1S4V A;  4GUA A;  3S3Q A;  1EWM A;  2OZ2 A;  2DC6 A;  1MDW A;  1SNK A;  3N3G A;  1CJL A;  4FIP A;  3MOR A;  1THE A;  6PAD A;  4BSQ A;  2DCA A;  3MHS A;  3PRM A;  1NLJ A;  1X9Y A;  1PVJ A;  3I06 A;  3N4C A;  4A5U A;  5K16 A;  4QRV A;  4BQV A;  1U9X A;  1AYW A;  1PPO A;  3PHW A;  3MHH A;  3V6E A;  1GCB A;  1PPP A;  2YJ8 A;  3IOQ A;  4P6E A;  4KLB A;  1BQI A;  2PAD A;  5CVM A;  1UKF A;  2PRE A;  5A24 A;  1KFX L;  4MI7 A;  4CDE B;  7PCK A;  4PP1 A;  1CB5 A;  2ATO A;  2IPP B;  4I04 A;  2FE8 A;  1VJV A;  1KFU L;  5FPW A;  1MEG A;  2E01 A;  1TL9 A;  1AU3 A;  3M99 A;  1PXV A;  1CSB B;  4PAD A;  1BY8 A;  4Q8G A;  3B79 A;  3BCN A;  2FRA A;  4QRX A;  3USV A;  5JH3 A;  4Q8H A;  3HHI A;  4R3D A;  2HD5 A;  1MHW A;  2DZZ A;  1NPZ A;  3DF0 A;  2AUZ A;  3LFY A;  3KKU A;  1GMY A;  3OF8 A;  1POP A;  1DEU A;  2DC7 A;  4QBB A;  4ZTB A;  2XU4 A;  1ATK A;  1KHQ A;  4XR7 A;  4REZ A;  3BBA A;  4K7C A;  4YV8 A;  2Y5B A;  4OVZ B;  4RNA A;  2XU5 A;  2PBH A;  3H89 A;  2OUL A;  3W31 A;  2YJB A;  1MS6 A;  3PBH A;  3PRP A;  3P5W A;  1QOL A;  1TLO A;  3HWN A;  4WA6 A;  4FJC A;  3MJ5 A;  3CH3 X;  4RF0 A;  1CV8 A;  5JZE A;  3HD3 A;  3S3R A;  4RF1 A;  4RKX A;  4XUI A;  1KHP A;  1AU0 A;  4D8B A;  4AXM A;  5E6J A;  4HXD B;  2ACT A;  4DMX A;  2E03 A;  1PBH A;  1PPD A;  3PT2 A;  2XU3 A;  2O6X A;  1CVZ A;  3IMA A;  4W4U A;  3PNR A;  1EWO A;  1FH0 A;  4IP3 A;  3RNV A;  4IUM A;  3OVZ A;  3BPM A;  1NB3 A;  3P5U A;  3F75 A;  4BS5 A;  2F1G A;  3PW3 A;  2AYO A;  5CVO B;  3IHP A;  1NL6 A;  2R9N A;  1BGO A;  5CVN B;  2R9M A;  3O65 A;  1VSN A;  3PSE A;  1CPJ A;  3I3T A;  2VHS A;  3KWZ A;  4D8I A;  1AYV A;  3PHX A;  1NB5 A;  4YYV A;  3TNX A;  2R9O A;  2Z84 A;  2YJ9 A;  4MM3 B;  4N4Z A;  2HXZ A;  3K8U A;  1AU4 A;  4QH6 A;  1PAD A;  3PHU A;  1BP4 A;  3E1Z B;  4D8E A;  2E02 A;  4FK5 A;  1TU6 A;  2BDZ A;  1Y4H A;  3O0U A;  4N8W A;  2FYE A;  4PT5 A;  1KXR A;  3QSD A;  3KX1 A;  4CDF B;  2DZY A;  2BU3 A;  4YYQ A;  2FQ9 A;  2NQA A;  3WXG A;  4OVZ A;  1F2C A;  2FUD A;  2C0Y A;  4MZS A;  3BWK A;  4YYU A;  1QDQ A;  2FT2 A;  1DKI A;  4N79 A;  3MTN A;  2P86 A;  2FRQ A;  4BOS A;  3TRK A;  2CB5 A;  4BOU A;  4XZX A;  4OEL A;  4OEM A;  2H7J A;  1AYU A;  5F02 A;  1U9V A;  3N3K A;  3K9M A;  3OIS A;  1XKG A;  1U5I A;  3H8C A;  1CQD A;  2NQG A;  4YVA A;  2NQI A;  1ZCM A;  5EZS A;  1ME4 A;  4I07 A;  3MTV A;  3IV2 A;  3LXS A;  1A6R A;  1YZB A; 
#chains in the Genus database with same CATH homology
 3PHW A;  3BY4 A;  2DOS A;  3MP2 A;  5EZQ A;  1UKF A;  3O65 A;  3PSE A;  4P16 A;  3TMP A;  4MI7 A;  2J7Q C;  3E9S A;  4D8I A;  2FE8 A;  3OQC A;  3PHX A;  2J7Q A;  2JRI A;  2Z84 A;  3BB7 A;  4MM3 B;  4R3D A;  4WUR A;  3PHU A;  4D8E A;  3B21 A;  4ZTB A;  4BOZ A;  4BOQ A;  4PT5 A;  4REZ A;  4M0W A;  3BBA A;  4OW0 A;  3W30 A;  2BU3 A;  4BOP A;  4OVZ B;  4RNA A;  3C0R A;  3W31 A;  4OVZ A;  3PRP A;  2JTC A;  2HWK A;  1DKI A;  2BTW B;  3MJ5 A;  4BOS A;  3TRK A;  4RF0 A;  4BOU A;  2BTW A;  5JZE A;  4XZX A;  4RF1 A;  4RKX A;  2UZJ A;  4D8B A;  5E6J A;  4GUA A;  4HXD B;  2AGA A;  3PT2 A;  3PRM A;  5EZS A;  1PVJ A;  3MTV A;  3ZNH A;  5KO3 A;  4IP3 A;  4A5U A;  3RNV A;  4IUM A;  3IFU A;  1YZB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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