4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase
molecule keywords Streptopain
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
4D8IA 2JTCA 2UZJA 1DKIA 4RKXA 3BBAA 3BB7A 4D8EA 4D8BA 1PVJA
chains in the Genus database with same CATH superfamily
3OVXA 4W5BA 3PHUA 9PAPA 1MEMA 3IHPA 4P6GA 2AYOA 4W4UA 1BP4A 3KX1A 1CSBB 5E6JA 5JH3A 1PE6A 1ME3A 2Y6EA 2XU4A 2DC6A 2YJ9A 3P5WA 4MI7A 3MORA 5PADA 5CHTA 1PBHA 4BOQA 2AS8A 5JA7A 4RKXA 5KO3A 2AIMA 1QXPA 3PRMA 1GECE 2HD5A 3OVZA 3CBJA 2AUZA 1F2BA 2FTDA 5EF4A 3USVA 2E01A 4FIPA 2XU3A 4REZA 1F2CA 4ZTBA 4YYSA 2DCCA 4IP3A 1ICFA 4QRVA 3AI8A 4QH6A 3TMPA 1TLOA 3C0RA 2Y5BA 2R9MA 2UZJA 4YYQA 2NQIA 2R9NA 3CH3X 4ZUXU 3K8UA 2FO5A 3BPFA 4D8EA 6PADA 2FUDA 2ARYA 1NQCA 3KKUA 2VHFA 3HWNA 3F5VA 3GCBA 2NQAA 4G54A 2E00A 1NB5A 1AU0A 3OQCA 8PCHA 2DZYA 2OZ2A 2J7QA 3BC3A 2FQ9A 1NPZA 3PSEA 2AGAA 3K9MA 3KWBX 4X6JA 3S3RA 5J94A 4YYVA 3CH2X 3KWZA 4K7CA 3BOWA 3QT4A 1PPDA 2DC9A 3V6EA 1UKFA 1BQIA 1PADA 2FT2A 1PXVA 2P0RA 3KFQA 1A6RA 4BOUA 2AVWA 2XU5A 1EWMA 5A24A 3H8BA 4RF1A 3LFYA 3B21A 1K3BB 4A5UA 3W30A 3H6SA 4PT5A 4RF0A 2BDZA 2HH5A 4QRXA 2DCAA 1ZCMA 3PDFA 1STFE 5CHVA 5CVMA 1U9VA 2PREA 1NLJA 4I05A 1Y08A 1KHQA 3MHSA 3OF9A 1U5IA 4CDEB 1U9XA 2P86A 2R6NA 3PNRA 4CDFB 1U9QX 2DC7A 3O0UA 3HD3A 3ZNHA 4AXLA 2G8EA 4BQVA 2G6DA 3PHXA 2AYNA 2CIOA 1MEGA 2PBHA 4D8IA 1NB3A 4XUIA 5F02A 4BOPA 4I07A 3LXSA 2DCBA 2B1MA 3H89A 2PNSA 1KFUL 3RVVA 3RNVA 2AUXA 4I04A 1CJLA 2JRIA 2P7UA 2HXZA 2WBFX 2DZZA 3BWKA 2YJCA 2JQGR 1GLOA 3W31A 2R9OA 1KHPA 4X6HA 1PPPA 1AIMA 1JQPA 1IWDA 1YT7A 2ACTA 3RVWA 1AU3A 1YVBA 4MM3B 3BY4A 2F1GA 2DJFB 4YVAA 1F2AA 1YZBA 4YYUA 5JZEA 3NHEA 1AECA 2J7QC 4P6EA 1DKIA 4HWYA 3KSEA 3D6SA 1ZIVA 1AYWA 2JTCA 4QBBA 1VSNA 1AYVA 2FE8A 1CTEA 3U8EA 1BGOA 2IPPB 3QJ3A 3IOQA 1EWLA 3N3KA 1EWPA 4OVZA 1DEUA 1EF7A 4Q8HA 4BS5A 3WXEA 3C9EA 4AXMA 1PCIA 4IUMA 4PI3A 4PADA 2Z84A 2FRQA 4RNAA 4KLBA 3MJ5A 3K24A 1PPOA 2G8JA 4FJCA 4M0WA 3KW9A 3B79A 1EWOA 2IBIA 3ERVA 2XU1A 7PCKA 3E1ZB 2PADA 3IV2A 3WXFA 3PHWA 4XZXA 3IFUA 1PIPA 3P5XA 4N4ZA 3CBKA 1CQDA 4DMYA 1KFXL 1TL9A 4WURA 2OP3A 2R9CA 3HHIA 1YK7A 4N79A 3V6CA 1MS6A 3BBAA 2AU1A 1CV8A 3TNXA 1CPJA 2OULA 4OVZB 3N3GA 4PP2E 4WA6A 3DF0A 4BOSA 1MDWA 2BU3A 3MHHA 4YYWA 1GMYA 4P16A 1Q6KA 1ME4A 1AYUA 4CDCB 2VHSA 3IUTA 2FYEA 2NQGA 3IMAA 4CDDB 3N4CA 3HHAA 1Y4HA 5EGWA 1CVZA 4N8WA 2HWKA 1ITOA 4MZSA 2YJBA 3IEJA 4BOZA 4X6IA 2BTWA 2DOSA 5FPWA 2O6XA 4DMXA 1VJVA 3O65A 5CVNB 5CVOB 2DJGB 4RY2A 1POPA 2GHUA 3H8CA 4MZOA 1KXRA 4Q8GA 3P5UA 2FRAA 1BY8A 3P5VA 5K16A 3PW3A 1O0EA 1SNKA 1SP4B 4CZWA 3I06A 2B1NA 1XKGA 3OF8A 4OEMA 2G7YA 1PPNA 4D8BA 1QDQA 2GFOA 1S4VA 3BB7A 5EZSA 3ZUAA 2E03A 4OELA 4BPVA 1QOLA 1F29A 2BTWB 4YYRA 4BSQA 1THEA 2H7JA 3MP2A 2YJ2A 4W5CA 1YALA 2R9FA 1AU4A 2ATOA 2CB5A 4MSXA 3O1GA 2F7DA 4PP1A 3RVXA 1QMYA 4FK5A 2NQDB 4OW0A 1MHWA 2DC8A 2JQFR 3TRKA 3BPMA 4XR7A 3H7DA 3BCNA 4HXDB 1M6DA 1ATKA 3E9SA 1CS8A 3PBHA 1YK8A 2DCDA 2HHNA 3M99A 1TU6A 2C0YA 1HUCB 2YJ8A 3WXGA 1CB5A 3MTNA 1X9YA 1PVJA 4R3DA 4QRGA 1MIRA 3OISA 5EZQA 3F75A 1U9WA 1FH0A 3MTVA 3PRPA 3QSDA 3I3TA 1DF0A 4GUAA 2BDLA 4BS6A 4YV8A 1AU2A 3PT2A 1NL6A 3S3QA 2E02A 1GCBA
chains in the Genus database with same CATH topology
4A5UA 2UZJA 2JRIA 3MP2A 3PHUA 4RNAA 3W30A 1UKFA 1DKIA 4PT5A 4RF0A 3MJ5A 4D8BA 3OQCA 4R3DA 1PVJA 4WURA 2J7QA 3W31A 2JTCA 5E6JA 3ZNHA 3PSEA 2AGAA 4M0WA 3O65A 2FE8A 3BBAA 3BB7A 3PHXA 4REZA 5EZQA 4BOUA 5EZSA 4D8EA 2J7QC 3MTVA 4OW0A 4D8IA 4ZTBA 4OVZA 4BOPA 3PRPA 4MI7A 4MM3B 4GUAA 3BY4A 4IP3A 2BTWB 4OVZB 3PHWA 3TRKA 4XZXA 3IFUA 2HWKA 1YZBA 3PRMA 4BOSA 4BOQA 2BU3A 3TMPA 5JZEA 4HXDB 4RKXA 3PT2A 4IUMA 3C0RA 4P16A 4RF1A 4BOZA 3RNVA 3E9SA 5KO3A 2Z84A 3B21A 2BTWA 2DOSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  2JTC A;  2UZJ A;  1DKI A;  4RKX A;  3BBA A;  3BB7 A;  4D8E A;  4D8B A;  1PVJ A; 
#chains in the Genus database with same CATH topology
 3OVX A;  4W5B A;  3PHU A;  9PAP A;  1MEM A;  3IHP A;  4P6G A;  2AYO A;  4W4U A;  1BP4 A;  3KX1 A;  1CSB B;  5E6J A;  5JH3 A;  1PE6 A;  1ME3 A;  2Y6E A;  2XU4 A;  2DC6 A;  2YJ9 A;  3P5W A;  4MI7 A;  3MOR A;  5PAD A;  5CHT A;  1PBH A;  4BOQ A;  2AS8 A;  5JA7 A;  4RKX A;  5KO3 A;  2AIM A;  1QXP A;  3PRM A;  1GEC E;  2HD5 A;  3OVZ A;  3CBJ A;  2AUZ A;  1F2B A;  2FTD A;  5EF4 A;  3USV A;  2E01 A;  4FIP A;  2XU3 A;  4REZ A;  1F2C A;  4ZTB A;  4YYS A;  2DCC A;  4IP3 A;  1ICF A;  4QRV A;  3AI8 A;  4QH6 A;  3TMP A;  1TLO A;  3C0R A;  2Y5B A;  2R9M A;  2UZJ A;  4YYQ A;  2NQI A;  2R9N A;  3CH3 X;  4ZUX U;  3K8U A;  2FO5 A;  3BPF A;  4D8E A;  6PAD A;  2FUD A;  2ARY A;  1NQC A;  3KKU A;  2VHF A;  3HWN A;  3F5V A;  3GCB A;  2NQA A;  4G54 A;  2E00 A;  1NB5 A;  1AU0 A;  3OQC A;  8PCH A;  2DZY A;  2OZ2 A;  2J7Q A;  3BC3 A;  2FQ9 A;  1NPZ A;  3PSE A;  2AGA A;  3K9M A;  3KWB X;  4X6J A;  3S3R A;  5J94 A;  4YYV A;  3CH2 X;  3KWZ A;  4K7C A;  3BOW A;  3QT4 A;  1PPD A;  2DC9 A;  3V6E A;  1UKF A;  1BQI A;  1PAD A;  2FT2 A;  1PXV A;  2P0R A;  3KFQ A;  1A6R A;  4BOU A;  2AVW A;  2XU5 A;  1EWM A;  5A24 A;  3H8B A;  4RF1 A;  3LFY A;  3B21 A;  1K3B B;  4A5U A;  3W30 A;  3H6S A;  4PT5 A;  4RF0 A;  2BDZ A;  2HH5 A;  4QRX A;  2DCA A;  1ZCM A;  3PDF A;  1STF E;  5CHV A;  5CVM A;  1U9V A;  2PRE A;  1NLJ A;  4I05 A;  1Y08 A;  1KHQ A;  3MHS A;  3OF9 A;  1U5I A;  4CDE B;  1U9X A;  2P86 A;  2R6N A;  3PNR A;  4CDF B;  1U9Q X;  2DC7 A;  3O0U A;  3HD3 A;  3ZNH A;  4AXL A;  2G8E A;  4BQV A;  2G6D A;  3PHX A;  2AYN A;  2CIO A;  1MEG A;  2PBH A;  4D8I A;  1NB3 A;  4XUI A;  5F02 A;  4BOP A;  4I07 A;  3LXS A;  2DCB A;  2B1M A;  3H89 A;  2PNS A;  1KFU L;  3RVV A;  3RNV A;  2AUX A;  4I04 A;  1CJL A;  2JRI A;  2P7U A;  2HXZ A;  2WBF X;  2DZZ A;  3BWK A;  2YJC A;  2JQG R;  1GLO A;  3W31 A;  2R9O A;  1KHP A;  4X6H A;  1PPP A;  1AIM A;  1JQP A;  1IWD A;  1YT7 A;  2ACT A;  3RVW A;  1AU3 A;  1YVB A;  4MM3 B;  3BY4 A;  2F1G A;  2DJF B;  4YVA A;  1F2A A;  1YZB A;  4YYU A;  5JZE A;  3NHE A;  1AEC A;  2J7Q C;  4P6E A;  1DKI A;  4HWY A;  3KSE A;  3D6S A;  1ZIV A;  1AYW A;  2JTC A;  4QBB A;  1VSN A;  1AYV A;  2FE8 A;  1CTE A;  3U8E A;  1BGO A;  2IPP B;  3QJ3 A;  3IOQ A;  1EWL A;  3N3K A;  1EWP A;  4OVZ A;  1DEU A;  1EF7 A;  4Q8H A;  4BS5 A;  3WXE A;  3C9E A;  4AXM A;  1PCI A;  4IUM A;  4PI3 A;  4PAD A;  2Z84 A;  2FRQ A;  4RNA A;  4KLB A;  3MJ5 A;  3K24 A;  1PPO A;  2G8J A;  4FJC A;  4M0W A;  3KW9 A;  3B79 A;  1EWO A;  2IBI A;  3ERV A;  2XU1 A;  7PCK A;  3E1Z B;  2PAD A;  3IV2 A;  3WXF A;  3PHW A;  4XZX A;  3IFU A;  1PIP A;  3P5X A;  4N4Z A;  3CBK A;  1CQD A;  4DMY A;  1KFX L;  1TL9 A;  4WUR A;  2OP3 A;  2R9C A;  3HHI A;  1YK7 A;  4N79 A;  3V6C A;  1MS6 A;  3BBA A;  2AU1 A;  1CV8 A;  3TNX A;  1CPJ A;  2OUL A;  4OVZ B;  3N3G A;  4PP2 E;  4WA6 A;  3DF0 A;  4BOS A;  1MDW A;  2BU3 A;  3MHH A;  4YYW A;  1GMY A;  4P16 A;  1Q6K A;  1ME4 A;  1AYU A;  4CDC B;  2VHS A;  3IUT A;  2FYE A;  2NQG A;  3IMA A;  4CDD B;  3N4C A;  3HHA A;  1Y4H A;  5EGW A;  1CVZ A;  4N8W A;  2HWK A;  1ITO A;  4MZS A;  2YJB A;  3IEJ A;  4BOZ A;  4X6I A;  2BTW A;  2DOS A;  5FPW A;  2O6X A;  4DMX A;  1VJV A;  3O65 A;  5CVN B;  5CVO B;  2DJG B;  4RY2 A;  1POP A;  2GHU A;  3H8C A;  4MZO A;  1KXR A;  4Q8G A;  3P5U A;  2FRA A;  1BY8 A;  3P5V A;  5K16 A;  3PW3 A;  1O0E A;  1SNK A;  1SP4 B;  4CZW A;  3I06 A;  2B1N A;  1XKG A;  3OF8 A;  4OEM A;  2G7Y A;  1PPN A;  4D8B A;  1QDQ A;  2GFO A;  1S4V A;  3BB7 A;  5EZS A;  3ZUA A;  2E03 A;  4OEL A;  4BPV A;  1QOL A;  1F29 A;  2BTW B;  4YYR A;  4BSQ A;  1THE A;  2H7J A;  3MP2 A;  2YJ2 A;  4W5C A;  1YAL A;  2R9F A;  1AU4 A;  2ATO A;  2CB5 A;  4MSX A;  3O1G A;  2F7D A;  4PP1 A;  3RVX A;  1QMY A;  4FK5 A;  2NQD B;  4OW0 A;  1MHW A;  2DC8 A;  2JQF R;  3TRK A;  3BPM A;  4XR7 A;  3H7D A;  3BCN A;  4HXD B;  1M6D A;  1ATK A;  3E9S A;  1CS8 A;  3PBH A;  1YK8 A;  2DCD A;  2HHN A;  3M99 A;  1TU6 A;  2C0Y A;  1HUC B;  2YJ8 A;  3WXG A;  1CB5 A;  3MTN A;  1X9Y A;  1PVJ A;  4R3D A;  4QRG A;  1MIR A;  3OIS A;  5EZQ A;  3F75 A;  1U9W A;  1FH0 A;  3MTV A;  3PRP A;  3QSD A;  3I3T A;  1DF0 A;  4GUA A;  2BDL A;  4BS6 A;  4YV8 A;  1AU2 A;  3PT2 A;  1NL6 A;  3S3Q A;  2E02 A;  1GCB A; 
#chains in the Genus database with same CATH homology
 4A5U A;  2UZJ A;  2JRI A;  3MP2 A;  3PHU A;  4RNA A;  3W30 A;  1UKF A;  1DKI A;  4PT5 A;  4RF0 A;  3MJ5 A;  4D8B A;  3OQC A;  4R3D A;  1PVJ A;  4WUR A;  2J7Q A;  3W31 A;  2JTC A;  5E6J A;  3ZNH A;  3PSE A;  2AGA A;  4M0W A;  3O65 A;  2FE8 A;  3BBA A;  3BB7 A;  3PHX A;  4REZ A;  5EZQ A;  4BOU A;  5EZS A;  4D8E A;  2J7Q C;  3MTV A;  4OW0 A;  4D8I A;  4ZTB A;  4OVZ A;  4BOP A;  3PRP A;  4MI7 A;  4MM3 B;  4GUA A;  3BY4 A;  4IP3 A;  2BTW B;  4OVZ B;  3PHW A;  3TRK A;  4XZX A;  3IFU A;  2HWK A;  1YZB A;  3PRM A;  4BOS A;  4BOQ A;  2BU3 A;  3TMP A;  5JZE A;  4HXD B;  4RKX A;  3PT2 A;  4IUM A;  3C0R A;  4P16 A;  4RF1 A;  4BOZ A;  3RNV A;  3E9S A;  5KO3 A;  2Z84 A;  3B21 A;  2BTW A;  2DOS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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