4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
b'QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
1PVJA 3BB7A 3BBAA 4D8EA 4D8BA 4D8IA 1DKIA 2JTCA 4RKXA 2UZJA
chains in the Genus database with same CATH superfamily
1CS8A 1JQPA 2FT2A 2UZJA 4OVZB 4CDEB 1HUCB 2PADA 2XU3A 4QRGA 2OULA 4AXMA 1KXRA 4DMXA 3KW9A 1AU2A 1CPJA 2AUXA 1SP4B 1X9YA 4PI3A 1F2CA 4YYQA 3I06A 4CDCB 5F02A 3N3KA 4ZUXU 3BB7A 1NB3A 1YK7A 1CTEA 4PT5A 3I3TA 1CB5A 2DZYA 1PPOA 4I05A 1QXPA 4X6IA 3PDFA 2PREA 1CSBB 2C0YA 4HXDB 3BWKA 2FRAA 2G7YA 3OVXA 1NL6A 3IUTA 2DC6A 4WURA 3KX1A 2AIMA 3AI8A 1CV8A 3H89A 7PCKA 1U9WA 1VJVA 3E1ZB 4Q8GA 3D6SA 1AU0A 1ICFA 1STFE 2VHSA 3TMPA 1DF0A 3IEJA 1THEA 4MM3B 1ATKA 1DEUA 1UKFA 1NQCA 1SNKA 5A24A 3U8EA 2B1NA 4YYWA 2JQFR 3IFUA 2O6XA 5CVMA 4YYUA 4I04A 3V6CA 2BDLA 4REZA 2YJ2A 1POPA 5EGWA 3HHAA 4ZTBA 4XZXA 4BSQA 1MS6A 3RVWA 2AS8A 2P0RA 3IV2A 4OW0A 2F1GA 1AECA 2XU4A 4QRXA 1ZCMA 4RNAA 3DF0A 2Y6EA 2CB5A 1NLJA 5J94A 2DCAA 1S4VA 2ATOA 3C9EA 4PP1A 3LXSA 4N79A 4X6JA 1AU3A 2HH5A 3BY4A 1KFUL 1M6DA 1MIRA 2GFOA 4DMYA 1MEGA 4IUMA 2HD5A 3KWBX 1GECE 1PVJA 2PBHA 4I07A 1KFXL 4AXLA 1MDWA 2FTDA 2NQIA 3IOQA 1MEMA 3W30A 1QDQA 3HD3A 1EWOA 4P16A 3MTVA 1ITOA 3CBJA 4R3DA 3KSEA 1XKGA 2YJ8A 3PNRA 2G6DA 5KO3A 3NHEA 2J7QA 1F2BA 4RKXA 4W5CA 3ZUAA 3E9SA 2YJCA 4D8EA 1PCIA 3K24A 3F5VA 3WXEA 4XUIA 3TRKA 5EZSA 4BS6A 2DCCA 3PBHA 4KLBA 4YVAA 4QBBA 2AGAA 1GMYA 3OF8A 3P5UA 3PRPA 6PADA 2AUZA 2FYEA 3GCBA 1CQDA 4M0WA 1U9XA 3P5XA 2WBFX 3BPFA 1DKIA 2B1MA 3H8BA 2BDZA 1ME3A 5JH3A 1BP4A 2DCBA 4N8WA 8PCHA 3N3GA 4FIPA 3TNXA 1YALA 4W5BA 4IP3A 3OVZA 1A6RA 1YVBA 1YZBA 3B21A 3H6SA 3MP2A 1AIMA 1AYVA 4YYSA 1EF7A 2JTCA 2HXZA 4BS5A 3O0UA 3V6EA 1PIPA 3S3RA 3QSDA 4W4UA 2DJFB 4D8BA 1K3BB 4WA6A 4HWYA 4A5UA 1U9VA 1U5IA 1QMYA 4BOSA 2NQGA 1NB5A 5PADA 4X6HA 3PHWA 2G8JA 4QRVA 3P5WA 1BGOA 1IWDA 4PP2E 1YK8A 1Y08A 3P5VA 5EZQA 5JA7A 4Q8HA 5JZEA 2HHNA 2VHFA 3RNVA 3CH3X 2CIOA 2P7UA 3O65A 3BBAA 1O0EA 4GUAA 1CVZA 1ZIVA 2DC7A 2DJGB 2XU1A 3BC3A 3PW3A 4MI7A 4MZOA 4YYRA 2OZ2A 3PSEA 1QOLA 2BTWA 3LFYA 1BQIA 2ARYA 1ME4A 1BY8A 3WXFA 4BQVA 2Z84A 5CHVA 2FE8A 1F2AA 1CJLA 1VSNA 2Y5BA 4CZWA 3QT4A 4FJCA 3MORA 4BOZA 4PADA 2AU1A 1Q6KA 2AVWA 2FRQA 1PPNA 5CVOB 4RY2A 3N4CA 1TL9A 2H7JA 5E6JA 2FQ9A 2FUDA 3CBKA 3IHPA 1PADA 1GCBA 2DZZA 2NQAA 1AYUA 3PHXA 2IPPB 1MHWA 3CH2X 1PXVA 3H7DA 3MTNA 5CHTA 2JQGR 3C0RA 4CDDB 2NQDB 5FPWA 3MHHA 2DC9A 2OP3A 2YJBA 2R9NA 3BCNA 4RF1A 1FH0A 2BTWB 3K8UA 4BOQA 3KKUA 1PE6A 2E00A 3WXGA 3PT2A 4YV8A 1PPPA 2DOSA 2R6NA 3ERVA 2E02A 4XR7A 3OQCA 1KHPA 4BPVA 3MHSA 1EWMA 9PAPA 4K7CA 4FK5A 2R9OA 1AU4A 2P86A 2XU5A 1KHQA 4MZSA 4P6GA 1GLOA 3KFQA 2JRIA 3RVVA 2IBIA 3M99A 2YJ9A 2HWKA 3PRMA 3HHIA 4OELA 2FO5A 3BOWA 1EWPA 3S3QA 3PHUA 2AYOA 3H8CA 3QJ3A 2GHUA 3USVA 4N4ZA 1NPZA 3OISA 2ACTA 2E03A 4OVZA 4BOUA 1Y4HA 3BPMA 3MJ5A 2R9FA 5K16A 3RVXA 3F75A 2DCDA 4BOPA 1TLOA 4MSXA 1PBHA 2F7DA 3K9MA 2R9MA 1U9QX 2AYNA 2G8EA 4OEMA 2BU3A 5EF4A 4QH6A 2PNSA 3OF9A 2E01A 2DC8A 1YT7A 3HWNA 5CVNB 4YYVA 3KWZA 3O1GA 2R9CA 1AYWA 3B79A 1PPDA 2J7QC 4G54A 3ZNHA 1EWLA 3IMAA 4D8IA 4P6EA 1F29A 4CDFB 4RF0A 1TU6A 3W31A
chains in the Genus database with same CATH topology
3BY4A 3PT2A 4D8BA 4IUMA 2UZJA 2DOSA 4A5UA 1PVJA 4OVZB 4BOSA 3OQCA 3PHWA 3W30A 5EZQA 2JRIA 3BB7A 4P16A 3MTVA 5JZEA 4PT5A 3RNVA 4R3DA 2HWKA 3O65A 3PRMA 3BBAA 5KO3A 4GUAA 4HXDB 2J7QA 4WURA 4MI7A 3PHUA 4RKXA 3PSEA 3E9SA 2BTWA 4D8EA 2Z84A 2FE8A 3TMPA 3TRKA 5EZSA 4MM3B 4OVZA 4BOUA 1UKFA 3MJ5A 4BOZA 4BOPA 2AGAA 3PRPA 3IFUA 2BU3A 4M0WA 4REZA 5E6JA 4ZTBA 4XZXA 4OW0A 1DKIA 4RNAA 3PHXA 2J7QC 3ZNHA 4D8IA 4IP3A 3C0RA 1YZBA 3B21A 3MP2A 4RF0A 4RF1A 2BTWB 2JTCA 3W31A 4BOQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PVJ A;  3BB7 A;  3BBA A;  4D8E A;  4D8B A;  4D8I A;  1DKI A;  2JTC A;  4RKX A;  2UZJ A; 
#chains in the Genus database with same CATH topology
 1CS8 A;  1JQP A;  2FT2 A;  2UZJ A;  4OVZ B;  4CDE B;  1HUC B;  2PAD A;  2XU3 A;  4QRG A;  2OUL A;  4AXM A;  1KXR A;  4DMX A;  3KW9 A;  1AU2 A;  1CPJ A;  2AUX A;  1SP4 B;  1X9Y A;  4PI3 A;  1F2C A;  4YYQ A;  3I06 A;  4CDC B;  5F02 A;  3N3K A;  4ZUX U;  3BB7 A;  1NB3 A;  1YK7 A;  1CTE A;  4PT5 A;  3I3T A;  1CB5 A;  2DZY A;  1PPO A;  4I05 A;  1QXP A;  4X6I A;  3PDF A;  2PRE A;  1CSB B;  2C0Y A;  4HXD B;  3BWK A;  2FRA A;  2G7Y A;  3OVX A;  1NL6 A;  3IUT A;  2DC6 A;  4WUR A;  3KX1 A;  2AIM A;  3AI8 A;  1CV8 A;  3H89 A;  7PCK A;  1U9W A;  1VJV A;  3E1Z B;  4Q8G A;  3D6S A;  1AU0 A;  1ICF A;  1STF E;  2VHS A;  3TMP A;  1DF0 A;  3IEJ A;  1THE A;  4MM3 B;  1ATK A;  1DEU A;  1UKF A;  1NQC A;  1SNK A;  5A24 A;  3U8E A;  2B1N A;  4YYW A;  2JQF R;  3IFU A;  2O6X A;  5CVM A;  4YYU A;  4I04 A;  3V6C A;  2BDL A;  4REZ A;  2YJ2 A;  1POP A;  5EGW A;  3HHA A;  4ZTB A;  4XZX A;  4BSQ A;  1MS6 A;  3RVW A;  2AS8 A;  2P0R A;  3IV2 A;  4OW0 A;  2F1G A;  1AEC A;  2XU4 A;  4QRX A;  1ZCM A;  4RNA A;  3DF0 A;  2Y6E A;  2CB5 A;  1NLJ A;  5J94 A;  2DCA A;  1S4V A;  2ATO A;  3C9E A;  4PP1 A;  3LXS A;  4N79 A;  4X6J A;  1AU3 A;  2HH5 A;  3BY4 A;  1KFU L;  1M6D A;  1MIR A;  2GFO A;  4DMY A;  1MEG A;  4IUM A;  2HD5 A;  3KWB X;  1GEC E;  1PVJ A;  2PBH A;  4I07 A;  1KFX L;  4AXL A;  1MDW A;  2FTD A;  2NQI A;  3IOQ A;  1MEM A;  3W30 A;  1QDQ A;  3HD3 A;  1EWO A;  4P16 A;  3MTV A;  1ITO A;  3CBJ A;  4R3D A;  3KSE A;  1XKG A;  2YJ8 A;  3PNR A;  2G6D A;  5KO3 A;  3NHE A;  2J7Q A;  1F2B A;  4RKX A;  4W5C A;  3ZUA A;  3E9S A;  2YJC A;  4D8E A;  1PCI A;  3K24 A;  3F5V A;  3WXE A;  4XUI A;  3TRK A;  5EZS A;  4BS6 A;  2DCC A;  3PBH A;  4KLB A;  4YVA A;  4QBB A;  2AGA A;  1GMY A;  3OF8 A;  3P5U A;  3PRP A;  6PAD A;  2AUZ A;  2FYE A;  3GCB A;  1CQD A;  4M0W A;  1U9X A;  3P5X A;  2WBF X;  3BPF A;  1DKI A;  2B1M A;  3H8B A;  2BDZ A;  1ME3 A;  5JH3 A;  1BP4 A;  2DCB A;  4N8W A;  8PCH A;  3N3G A;  4FIP A;  3TNX A;  1YAL A;  4W5B A;  4IP3 A;  3OVZ A;  1A6R A;  1YVB A;  1YZB A;  3B21 A;  3H6S A;  3MP2 A;  1AIM A;  1AYV A;  4YYS A;  1EF7 A;  2JTC A;  2HXZ A;  4BS5 A;  3O0U A;  3V6E A;  1PIP A;  3S3R A;  3QSD A;  4W4U A;  2DJF B;  4D8B A;  1K3B B;  4WA6 A;  4HWY A;  4A5U A;  1U9V A;  1U5I A;  1QMY A;  4BOS A;  2NQG A;  1NB5 A;  5PAD A;  4X6H A;  3PHW A;  2G8J A;  4QRV A;  3P5W A;  1BGO A;  1IWD A;  4PP2 E;  1YK8 A;  1Y08 A;  3P5V A;  5EZQ A;  5JA7 A;  4Q8H A;  5JZE A;  2HHN A;  2VHF A;  3RNV A;  3CH3 X;  2CIO A;  2P7U A;  3O65 A;  3BBA A;  1O0E A;  4GUA A;  1CVZ A;  1ZIV A;  2DC7 A;  2DJG B;  2XU1 A;  3BC3 A;  3PW3 A;  4MI7 A;  4MZO A;  4YYR A;  2OZ2 A;  3PSE A;  1QOL A;  2BTW A;  3LFY A;  1BQI A;  2ARY A;  1ME4 A;  1BY8 A;  3WXF A;  4BQV A;  2Z84 A;  5CHV A;  2FE8 A;  1F2A A;  1CJL A;  1VSN A;  2Y5B A;  4CZW A;  3QT4 A;  4FJC A;  3MOR A;  4BOZ A;  4PAD A;  2AU1 A;  1Q6K A;  2AVW A;  2FRQ A;  1PPN A;  5CVO B;  4RY2 A;  3N4C A;  1TL9 A;  2H7J A;  5E6J A;  2FQ9 A;  2FUD A;  3CBK A;  3IHP A;  1PAD A;  1GCB A;  2DZZ A;  2NQA A;  1AYU A;  3PHX A;  2IPP B;  1MHW A;  3CH2 X;  1PXV A;  3H7D A;  3MTN A;  5CHT A;  2JQG R;  3C0R A;  4CDD B;  2NQD B;  5FPW A;  3MHH A;  2DC9 A;  2OP3 A;  2YJB A;  2R9N A;  3BCN A;  4RF1 A;  1FH0 A;  2BTW B;  3K8U A;  4BOQ A;  3KKU A;  1PE6 A;  2E00 A;  3WXG A;  3PT2 A;  4YV8 A;  1PPP A;  2DOS A;  2R6N A;  3ERV A;  2E02 A;  4XR7 A;  3OQC A;  1KHP A;  4BPV A;  3MHS A;  1EWM A;  9PAP A;  4K7C A;  4FK5 A;  2R9O A;  1AU4 A;  2P86 A;  2XU5 A;  1KHQ A;  4MZS A;  4P6G A;  1GLO A;  3KFQ A;  2JRI A;  3RVV A;  2IBI A;  3M99 A;  2YJ9 A;  2HWK A;  3PRM A;  3HHI A;  4OEL A;  2FO5 A;  3BOW A;  1EWP A;  3S3Q A;  3PHU A;  2AYO A;  3H8C A;  3QJ3 A;  2GHU A;  3USV A;  4N4Z A;  1NPZ A;  3OIS A;  2ACT A;  2E03 A;  4OVZ A;  4BOU A;  1Y4H A;  3BPM A;  3MJ5 A;  2R9F A;  5K16 A;  3RVX A;  3F75 A;  2DCD A;  4BOP A;  1TLO A;  4MSX A;  1PBH A;  2F7D A;  3K9M A;  2R9M A;  1U9Q X;  2AYN A;  2G8E A;  4OEM A;  2BU3 A;  5EF4 A;  4QH6 A;  2PNS A;  3OF9 A;  2E01 A;  2DC8 A;  1YT7 A;  3HWN A;  5CVN B;  4YYV A;  3KWZ A;  3O1G A;  2R9C A;  1AYW A;  3B79 A;  1PPD A;  2J7Q C;  4G54 A;  3ZNH A;  1EWL A;  3IMA A;  4D8I A;  4P6E A;  1F29 A;  4CDF B;  4RF0 A;  1TU6 A;  3W31 A; 
#chains in the Genus database with same CATH homology
 3BY4 A;  3PT2 A;  4D8B A;  4IUM A;  2UZJ A;  2DOS A;  4A5U A;  1PVJ A;  4OVZ B;  4BOS A;  3OQC A;  3PHW A;  3W30 A;  5EZQ A;  2JRI A;  3BB7 A;  4P16 A;  3MTV A;  5JZE A;  4PT5 A;  3RNV A;  4R3D A;  2HWK A;  3O65 A;  3PRM A;  3BBA A;  5KO3 A;  4GUA A;  4HXD B;  2J7Q A;  4WUR A;  4MI7 A;  3PHU A;  4RKX A;  3PSE A;  3E9S A;  2BTW A;  4D8E A;  2Z84 A;  2FE8 A;  3TMP A;  3TRK A;  5EZS A;  4MM3 B;  4OVZ A;  4BOU A;  1UKF A;  3MJ5 A;  4BOZ A;  4BOP A;  2AGA A;  3PRP A;  3IFU A;  2BU3 A;  4M0W A;  4REZ A;  5E6J A;  4ZTB A;  4XZX A;  4OW0 A;  1DKI A;  4RNA A;  3PHX A;  2J7Q C;  3ZNH A;  4D8I A;  4IP3 A;  3C0R A;  1YZB A;  3B21 A;  3MP2 A;  4RF0 A;  4RF1 A;  2BTW B;  2JTC A;  3W31 A;  4BOQ A; 
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similar chains in the Genus database (?% sequence similarity)
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