4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
molecule tags Hydrolase
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
1PVJA 2UZJA 3BB7A 4D8EA 4D8IA 2JTCA 1DKIA 4D8BA 3BBAA 4RKXA
chains in the Genus database with same CATH superfamily
2AVWA 1DF0A 3BPFA 3RVVA 2DC9A 1K3BB 2FRQA 2R9FA 1TL9A 3OVXA 2FT2A 1AYUA 3TMPA 3QJ3A 4XZXA 4PP1A 2Y5BA 1YT7A 3M99A 2G6DA 3O0UA 4KLBA 3MHSA 1FH0A 4MM3B 3S3RA 1A6RA 2R9NA 4Q8HA 2FE8A 4BOUA 1EWOA 2O6XA 8PCHA 3P5UA 3S3QA 2HHNA 5EGWA 2AUXA 1QMYA 4CDEB 4YYSA 1AYVA 3KWZA 2AS8A 4IUMA 3RVWA 3CH2X 2XU4A 2P0RA 4CDFB 3F75A 4OELA 2AIMA 2B1MA 2G8EA 2DCCA 3MTNA 4YYQA 1CVZA 2E01A 2BDLA 5JH3A 1TLOA 2AUZA 5JA7A 4CZWA 1SP4B 3IEJA 3CH3X 3PBHA 5CVNB 1AU4A 4DMXA 4PT5A 3OISA 4I05A 4MSXA 4YV8A 1ATKA 5CHTA 3V6EA 1MHWA 1CQDA 2Z84A 4D8EA 3KWBX 2CIOA 3BBAA 3HD3A 2YJ2A 1U9XA 3KX1A 4A5UA 4AXMA 3H7DA 3MHHA 1F29A 4RF1A 3E9SA 4N79A 2HWKA 2H7JA 3KKUA 3CBJA 1AIMA 4GUAA 3K24A 3GCBA 3USVA 1ME3A 1JQPA 1GMYA 2DOSA 5J94A 4FJCA 3PHWA 2Y6EA 2NQIA 1PBHA 3P5WA 4PADA 4W4UA 4P6GA 1CTEA 2B1NA 3KSEA 3IUTA 1QXPA 2R9CA 3LFYA 4YYWA 5FPWA 1O0EA 1Q6KA 3OQCA 2ARYA 1EF7A 3E1ZB 9PAPA 3PRMA 4QRGA 2JQFR 2DZZA 2FQ9A 3QSDA 3HWNA 4RNAA 1KFUL 1KXRA 1CPJA 1NLJA 1AU0A 4X6JA 3AI8A 3OF9A 2UZJA 1DKIA 4G54A 3PNRA 1MIRA 4MZOA 3WXGA 2IPPB 1CJLA 4AXLA 4YYVA 5F02A 1IWDA 2DC7A 1U5IA 4D8BA 3B21A 2J7QA 2OZ2A 1PXVA 1VSNA 2P7UA 2G8JA 1PPNA 3P5VA 5CHVA 1PPOA 3IOQA 3O65A 2VHFA 5E6JA 1PADA 2JRIA 2R9OA 3QT4A 4P16A 4Q8GA 1HUCB 3NHEA 2YJCA 1ITOA 1KHPA 3KW9A 1QOLA 4K7CA 3TRKA 5KO3A 4X6HA 4PI3A 1MDWA 1PE6A 1YK7A 3BY4A 6PADA 3RNVA 2CB5A 4N8WA 1ME4A 3MP2A 2FUDA 3H89A 2E03A 1NB5A 3N4CA 1MS6A 2YJ8A 2R6NA 4IP3A 1KFXL 1F2AA 3MJ5A 1AU2A 1SNKA 2HXZA 4X6IA 1F2BA 1VJVA 2DC6A 2DZYA 3BWKA 3LXSA 4DMYA 4MZSA 4RY2A 3C0RA 3PHXA 4P6EA 2XU5A 3IFUA 3PW3A 3V6CA 3D6SA 1POPA 4QBBA 1PPDA 4FK5A 5CVOB 3BC3A 1BP4A 3PDFA 1BY8A 2P86A 1X9YA 2XU3A 4OVZA 4XR7A 1Y4HA 2FO5A 3P5XA 1U9WA 1KHQA 3H8CA 3CBKA 3PT2A 2E02A 1NL6A 2FYEA 3HHIA 1QDQA 5JZEA 4WA6A 1DEUA 1PPPA 2NQDB 1F2CA 5EZQA 2GHUA 2PREA 2ATOA 4I04A 2BU3A 4BOZA 3HHAA 3ZNHA 2R9MA 4BOSA 2DJGB 4OEMA 2WBFX 4QRXA 2PBHA 3B79A 3BOWA 3H8BA 1U9QX 1NPZA 2DCDA 3DF0A 4N4ZA 2OP3A 2BDZA 1ZIVA 1Y08A 1M6DA 2HH5A 2DC8A 3PSEA 4CDCB 2XU1A 4BPVA 4D8IA 2DJFB 2GFOA 1EWLA 2AYNA 2AGAA 2FTDA 1GLOA 4FIPA 2VHSA 3H6SA 3WXFA 3W30A 3K9MA 7PCKA 1ZCMA 2OULA 2J7QC 5CVMA 3N3KA 4OVZB 3IV2A 1NB3A 2F7DA 1BGOA 5PADA 2PADA 3O1GA 4PP2E 1U9VA 3BCNA 1GECE 3ERVA 1CS8A 2DCAA 4M0WA 2DCBA 4W5BA 3F5VA 2BTWA 3TNXA 1STFE 1PIPA 1PCIA 4WURA 3I3TA 1BQIA 1AECA 2FRAA 1EWPA 2YJ9A 2E00A 4HWYA 4XUIA 4BS6A 2ACTA 2NQGA 3MORA 5K16A 3U8EA 3PHUA 4BSQA 1AU3A 1YK8A 4W5CA 1PVJA 3BB7A 4QH6A 1YALA 1MEMA 3N3GA 4HXDB 2YJBA 4R3DA 2IBIA 2JTCA 3RVXA 3OF8A 3IHPA 4MI7A 3C9EA 4OW0A 1TU6A 5A24A 3WXEA 1CB5A 4BOQA 1THEA 2AYOA 4BS5A 3BPMA 3KFQA 4RF0A 4QRVA 2JQGR 2PNSA 3I06A 5EF4A 1AYWA 1CSBB 3W31A 1MEGA 4BQVA 1S4VA 2HD5A 4ZTBA 1GCBA 1CV8A 3IMAA 4I07A 4REZA 4YYUA 1YVBA 2C0YA 3OVZA 4CDDB 3PRPA 2AU1A 4YYRA 4ZUXU 2BTWB 1NQCA 2NQAA 4YVAA 4RKXA 1EWMA 3K8UA 2G7YA 5EZSA 3ZUAA 4BOPA 2F1GA 1XKGA 1YZBA 1UKFA 1ICFA 3MTVA
chains in the Genus database with same CATH topology
4RF1A 3E9SA 4OVZB 2HWKA 4GUAA 3C0RA 3PHXA 3IFUA 4M0WA 3TMPA 4XZXA 2BTWA 2DOSA 3PHWA 4WURA 4OVZA 4MM3B 3OQCA 2FE8A 4BOUA 3PRMA 3PT2A 4RNAA 3PHUA 1PVJA 3BB7A 4IUMA 5JZEA 4HXDB 4R3DA 2UZJA 5EZQA 2JTCA 1DKIA 4MI7A 2BU3A 4OW0A 4BOZA 4D8BA 4BOQA 3B21A 2J7QA 3ZNHA 4BOSA 4RF0A 3O65A 4PT5A 5E6JA 2JRIA 3W31A 4P16A 4ZTBA 4REZA 3TRKA 3PSEA 5KO3A 3BY4A 3PRPA 4D8IA 3RNVA 2Z84A 2BTWB 4D8EA 3MP2A 2AGAA 3BBAA 4RKXA 5EZSA 3W30A 4IP3A 4BOPA 4A5UA 1YZBA 1UKFA 2J7QC 3MJ5A 3MTVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PVJ A;  2UZJ A;  3BB7 A;  4D8E A;  4D8I A;  2JTC A;  1DKI A;  4D8B A;  3BBA A;  4RKX A; 
#chains in the Genus database with same CATH topology
 2AVW A;  1DF0 A;  3BPF A;  3RVV A;  2DC9 A;  1K3B B;  2FRQ A;  2R9F A;  1TL9 A;  3OVX A;  2FT2 A;  1AYU A;  3TMP A;  3QJ3 A;  4XZX A;  4PP1 A;  2Y5B A;  1YT7 A;  3M99 A;  2G6D A;  3O0U A;  4KLB A;  3MHS A;  1FH0 A;  4MM3 B;  3S3R A;  1A6R A;  2R9N A;  4Q8H A;  2FE8 A;  4BOU A;  1EWO A;  2O6X A;  8PCH A;  3P5U A;  3S3Q A;  2HHN A;  5EGW A;  2AUX A;  1QMY A;  4CDE B;  4YYS A;  1AYV A;  3KWZ A;  2AS8 A;  4IUM A;  3RVW A;  3CH2 X;  2XU4 A;  2P0R A;  4CDF B;  3F75 A;  4OEL A;  2AIM A;  2B1M A;  2G8E A;  2DCC A;  3MTN A;  4YYQ A;  1CVZ A;  2E01 A;  2BDL A;  5JH3 A;  1TLO A;  2AUZ A;  5JA7 A;  4CZW A;  1SP4 B;  3IEJ A;  3CH3 X;  3PBH A;  5CVN B;  1AU4 A;  4DMX A;  4PT5 A;  3OIS A;  4I05 A;  4MSX A;  4YV8 A;  1ATK A;  5CHT A;  3V6E A;  1MHW A;  1CQD A;  2Z84 A;  4D8E A;  3KWB X;  2CIO A;  3BBA A;  3HD3 A;  2YJ2 A;  1U9X A;  3KX1 A;  4A5U A;  4AXM A;  3H7D A;  3MHH A;  1F29 A;  4RF1 A;  3E9S A;  4N79 A;  2HWK A;  2H7J A;  3KKU A;  3CBJ A;  1AIM A;  4GUA A;  3K24 A;  3GCB A;  3USV A;  1ME3 A;  1JQP A;  1GMY A;  2DOS A;  5J94 A;  4FJC A;  3PHW A;  2Y6E A;  2NQI A;  1PBH A;  3P5W A;  4PAD A;  4W4U A;  4P6G A;  1CTE A;  2B1N A;  3KSE A;  3IUT A;  1QXP A;  2R9C A;  3LFY A;  4YYW A;  5FPW A;  1O0E A;  1Q6K A;  3OQC A;  2ARY A;  1EF7 A;  3E1Z B;  9PAP A;  3PRM A;  4QRG A;  2JQF R;  2DZZ A;  2FQ9 A;  3QSD A;  3HWN A;  4RNA A;  1KFU L;  1KXR A;  1CPJ A;  1NLJ A;  1AU0 A;  4X6J A;  3AI8 A;  3OF9 A;  2UZJ A;  1DKI A;  4G54 A;  3PNR A;  1MIR A;  4MZO A;  3WXG A;  2IPP B;  1CJL A;  4AXL A;  4YYV A;  5F02 A;  1IWD A;  2DC7 A;  1U5I A;  4D8B A;  3B21 A;  2J7Q A;  2OZ2 A;  1PXV A;  1VSN A;  2P7U A;  2G8J A;  1PPN A;  3P5V A;  5CHV A;  1PPO A;  3IOQ A;  3O65 A;  2VHF A;  5E6J A;  1PAD A;  2JRI A;  2R9O A;  3QT4 A;  4P16 A;  4Q8G A;  1HUC B;  3NHE A;  2YJC A;  1ITO A;  1KHP A;  3KW9 A;  1QOL A;  4K7C A;  3TRK A;  5KO3 A;  4X6H A;  4PI3 A;  1MDW A;  1PE6 A;  1YK7 A;  3BY4 A;  6PAD A;  3RNV A;  2CB5 A;  4N8W A;  1ME4 A;  3MP2 A;  2FUD A;  3H89 A;  2E03 A;  1NB5 A;  3N4C A;  1MS6 A;  2YJ8 A;  2R6N A;  4IP3 A;  1KFX L;  1F2A A;  3MJ5 A;  1AU2 A;  1SNK A;  2HXZ A;  4X6I A;  1F2B A;  1VJV A;  2DC6 A;  2DZY A;  3BWK A;  3LXS A;  4DMY A;  4MZS A;  4RY2 A;  3C0R A;  3PHX A;  4P6E A;  2XU5 A;  3IFU A;  3PW3 A;  3V6C A;  3D6S A;  1POP A;  4QBB A;  1PPD A;  4FK5 A;  5CVO B;  3BC3 A;  1BP4 A;  3PDF A;  1BY8 A;  2P86 A;  1X9Y A;  2XU3 A;  4OVZ A;  4XR7 A;  1Y4H A;  2FO5 A;  3P5X A;  1U9W A;  1KHQ A;  3H8C A;  3CBK A;  3PT2 A;  2E02 A;  1NL6 A;  2FYE A;  3HHI A;  1QDQ A;  5JZE A;  4WA6 A;  1DEU A;  1PPP A;  2NQD B;  1F2C A;  5EZQ A;  2GHU A;  2PRE A;  2ATO A;  4I04 A;  2BU3 A;  4BOZ A;  3HHA A;  3ZNH A;  2R9M A;  4BOS A;  2DJG B;  4OEM A;  2WBF X;  4QRX A;  2PBH A;  3B79 A;  3BOW A;  3H8B A;  1U9Q X;  1NPZ A;  2DCD A;  3DF0 A;  4N4Z A;  2OP3 A;  2BDZ A;  1ZIV A;  1Y08 A;  1M6D A;  2HH5 A;  2DC8 A;  3PSE A;  4CDC B;  2XU1 A;  4BPV A;  4D8I A;  2DJF B;  2GFO A;  1EWL A;  2AYN A;  2AGA A;  2FTD A;  1GLO A;  4FIP A;  2VHS A;  3H6S A;  3WXF A;  3W30 A;  3K9M A;  7PCK A;  1ZCM A;  2OUL A;  2J7Q C;  5CVM A;  3N3K A;  4OVZ B;  3IV2 A;  1NB3 A;  2F7D A;  1BGO A;  5PAD A;  2PAD A;  3O1G A;  4PP2 E;  1U9V A;  3BCN A;  1GEC E;  3ERV A;  1CS8 A;  2DCA A;  4M0W A;  2DCB A;  4W5B A;  3F5V A;  2BTW A;  3TNX A;  1STF E;  1PIP A;  1PCI A;  4WUR A;  3I3T A;  1BQI A;  1AEC A;  2FRA A;  1EWP A;  2YJ9 A;  2E00 A;  4HWY A;  4XUI A;  4BS6 A;  2ACT A;  2NQG A;  3MOR A;  5K16 A;  3U8E A;  3PHU A;  4BSQ A;  1AU3 A;  1YK8 A;  4W5C A;  1PVJ A;  3BB7 A;  4QH6 A;  1YAL A;  1MEM A;  3N3G A;  4HXD B;  2YJB A;  4R3D A;  2IBI A;  2JTC A;  3RVX A;  3OF8 A;  3IHP A;  4MI7 A;  3C9E A;  4OW0 A;  1TU6 A;  5A24 A;  3WXE A;  1CB5 A;  4BOQ A;  1THE A;  2AYO A;  4BS5 A;  3BPM A;  3KFQ A;  4RF0 A;  4QRV A;  2JQG R;  2PNS A;  3I06 A;  5EF4 A;  1AYW A;  1CSB B;  3W31 A;  1MEG A;  4BQV A;  1S4V A;  2HD5 A;  4ZTB A;  1GCB A;  1CV8 A;  3IMA A;  4I07 A;  4REZ A;  4YYU A;  1YVB A;  2C0Y A;  3OVZ A;  4CDD B;  3PRP A;  2AU1 A;  4YYR A;  4ZUX U;  2BTW B;  1NQC A;  2NQA A;  4YVA A;  4RKX A;  1EWM A;  3K8U A;  2G7Y A;  5EZS A;  3ZUA A;  4BOP A;  2F1G A;  1XKG A;  1YZB A;  1UKF A;  1ICF A;  3MTV A; 
#chains in the Genus database with same CATH homology
 4RF1 A;  3E9S A;  4OVZ B;  2HWK A;  4GUA A;  3C0R A;  3PHX A;  3IFU A;  4M0W A;  3TMP A;  4XZX A;  2BTW A;  2DOS A;  3PHW A;  4WUR A;  4OVZ A;  4MM3 B;  3OQC A;  2FE8 A;  4BOU A;  3PRM A;  3PT2 A;  4RNA A;  3PHU A;  1PVJ A;  3BB7 A;  4IUM A;  5JZE A;  4HXD B;  4R3D A;  2UZJ A;  5EZQ A;  2JTC A;  1DKI A;  4MI7 A;  2BU3 A;  4OW0 A;  4BOZ A;  4D8B A;  4BOQ A;  3B21 A;  2J7Q A;  3ZNH A;  4BOS A;  4RF0 A;  3O65 A;  4PT5 A;  5E6J A;  2JRI A;  3W31 A;  4P16 A;  4ZTB A;  4REZ A;  3TRK A;  3PSE A;  5KO3 A;  3BY4 A;  3PRP A;  4D8I A;  3RNV A;  2Z84 A;  2BTW B;  4D8E A;  3MP2 A;  2AGA A;  3BBA A;  4RKX A;  5EZS A;  3W30 A;  4IP3 A;  4BOP A;  4A5U A;  1YZB A;  1UKF A;  2J7Q C;  3MJ5 A;  3MTV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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