2J7QA

Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein m48 in complex with a ubquitin-based suicide substrate
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
232
structure length
232
Chain Sequence
MKIVRASRDQSAPVYGPRAGSQCMSNCFTFLHTCYLMGIDPVLDTTSLDAVLDSGARLDAIADEKVKRQALTDHPYRLGTEIPTVIETPAGITGHALSRPFNGTAETQDLGGYKCLGILDFLTYARGKPLPVYIIVTVGVHTRGVIVARGATYVFDPHTTDLSAEAAVYVCDDFTEAISALSFFTEMIGDFYYDAVLVYFTRCRTTLISPSELLVQIMDQYKDPDIDASVMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
pubmed doi rcsb
molecule tags Hydrolase
source organism Murine cytomegalovirus
molecule keywords MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEA
total genus 69
structure length 232
sequence length 232
ec nomenclature
pdb deposition date 2006-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.120 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 2j7qA00
2J7QA 2J7QC
chains in the Genus database with same CATH superfamily
4PP2E 1CV8A 1CVZA 1ZIVA 4BS5A 3DF0A 2PBHA 1PPOA 3PRMA 1CSBB 5EZSA 4CDEB 3MHSA 4BOSA 4YYRA 3KX1A 2YJ9A 4XUIA 2DCAA 4N4ZA 3TRKA 1CQDA 3BBAA 4D8IA 1NB5A 5JZEA 2XU4A 3USVA 2R6NA 1PCIA 1CB5A 2JQFR 1U9VA 4YYSA 3BPMA 4KLBA 4PT5A 3E1ZB 3IEJA 2Y6EA 2IBIA 4RY2A 3O0UA 3V6CA 2DJGB 5CVMA 4D8BA 2XU5A 3H7DA 2JTCA 3C9EA 5JA7A 2FTDA 3HHAA 2O6XA 4X6HA 3PT2A 4YYQA 2DCBA 1TLOA 4IP3A 2DCDA 4WURA 3BOWA 3S3QA 4W4UA 3I06A 3KFQA 4QRVA 2PREA 4P16A 2R9NA 3O65A 1GCBA 8PCHA 4MZSA 3PHUA 3S3RA 3WXFA 2E00A 2XU3A 2FT2A 2OULA 3MORA 1AU2A 1CJLA 4RF1A 1M6DA 4AXLA 4MI7A 2YJBA 1CS8A 3KWZA 4OVZA 3OVZA 1CPJA 5JH3A 5CVOB 3ZNHA 1QXPA 4W5BA 4CZWA 4MZOA 5KO3A 3TNXA 2DC7A 3D6SA 1EF7A 1ATKA 4RKXA 3IUTA 2BTWB 2VHFA 1MEMA 2WBFX 2F7DA 3IFUA 3H8BA 1F29A 1PPNA 1U9XA 2Y5BA 3QJ3A 2DOSA 1EWLA 1YZBA 2Z84A 1XKGA 1Q6KA 2AS8A 3H89A 4Q8GA 7PCKA 1YK7A 2AUXA 3OQCA 4OEMA 4P6GA 4PADA 2GFOA 1KHQA 1F2CA 1AYVA 3KKUA 3RVXA 2J7QC 1IWDA 5EZQA 3MTNA 4MSXA 4BOPA 3NHEA 4Q8HA 2FO5A 1EWOA 3WXEA 4OVZB 1QOLA 1PE6A 3BB7A 5F02A 3KSEA 4DMYA 1F2AA 4G54A 4HXDB 3OF9A 1HUCB 2BDZA 1Y08A 3W31A 4CDFB 3F5VA 1AYWA 1KHPA 3HHIA 2FE8A 2R9CA 3TMPA 4HWYA 4BOUA 3GCBA 1AU0A 2E01A 2P86A 1BQIA 1NL6A 1PPDA 4DMXA 1DEUA 1SP4B 1Y4HA 3K24A 3QSDA 3U8EA 4FK5A 2AGAA 4BS6A 5FPWA 3PDFA 1AECA 1DF0A 4QRXA 2FRAA 1BGOA 1DKIA 3PNRA 2P0RA 1ITOA 1YALA 3V6EA 4A5UA 4XR7A 2NQAA 2HD5A 1S4VA 2YJCA 2YJ2A 4FJCA 3CH3X 2G7YA 2NQGA 2FRQA 3PHWA 2F1GA 3OVXA 4BPVA 1MEGA 4PI3A 5EGWA 1NLJA 3MJ5A 1PXVA 1TL9A 3BY4A 1KFXL 3W30A 4AXMA 3AI8A 1PIPA 1PVJA 5CHTA 4CDDB 1NPZA 1YT7A 3PSEA 3RVVA 1GLOA 2G6DA 1QMYA 1ME3A 3KWBX 4I04A 4YYWA 1K3BB 1FH0A 5EF4A 4P6EA 4D8EA 2CB5A 1ZCMA 1YK8A 3P5WA 1MS6A 4WA6A 2ARYA 2DC8A 3IOQA 3B79A 4W5CA 3RNVA 3K8UA 3QT4A 4M0WA 4R3DA 2CIOA 2HHNA 3ZUAA 2UZJA 4YYVA 4MM3B 4CDCB 2DC6A 3IMAA 1TU6A 2PNSA 2B1NA 4FIPA 2G8EA 3M99A 3N4CA 5J94A 1VJVA 1F2BA 2NQDB 2IPPB 1UKFA 1U9WA 3F75A 2C0YA 2AUZA 2DC9A 1AU4A 1VSNA 4XZXA 3OF8A 1X9YA 1EWPA 1U5IA 2H7JA 5E6JA 2XU1A 1THEA 4I05A 4X6JA 1STFE 2DZZA 4QRGA 3HD3A 3MP2A 3B21A 1SNKA 3P5UA 4QBBA 3H6SA 4YV8A 3BC3A 4RF0A 2P7UA 2ACTA 4REZA 1KFUL 1EWMA 1O0EA 3I3TA 2FQ9A 3H8CA 1YVBA 2ATOA 2DJFB 3IHPA 6PADA 1BY8A 3OISA 1PADA 4BOQA 3CBJA 2PADA 3ERVA 2OZ2A 2R9OA 3C0RA 3CH2X 1AU3A 1GMYA 3CBKA 2BTWA 1QDQA 2FUDA 1PPPA 4YVAA 3E9SA 1MHWA 3K9MA 1AYUA 4N8WA 4PP1A 2R9FA 3PHXA 1ME4A 3P5VA 2NQIA 1AIMA 3PRPA 2YJ8A 1A6RA 2HXZA 3KW9A 2AVWA 3N3GA 2BU3A 2VHSA 2B1MA 4OELA 2AYOA 2R9MA 3RVWA 4BOZA 1NQCA 4BQVA 4BSQA 3MTVA 1MDWA 1PBHA 1NB3A 3WXGA 2E02A 2AU1A 2OP3A 3IV2A 4I07A 3N3KA 4YYUA 4N79A 5A24A 2G8JA 1CTEA 1U9QX 1GECE 2JQGR 3BCNA 1BP4A 2DZYA 2JRIA 4K7CA 1JQPA 3HWNA 2E03A 3LFYA 4X6IA 4OW0A 5K16A 3O1GA 2DCCA 3LXSA 1KXRA 2GHUA 3PW3A 2HH5A 1ICFA 5CHVA 2BDLA 4QH6A 4ZTBA 3MHHA 2J7QA 2AYNA 3BWKA 9PAPA 4RNAA 2AIMA 3P5XA 2FYEA 1MIRA 2HWKA 5PADA 4ZUXU 3PBHA 4IUMA 3BPFA 5CVNB 4GUAA 1POPA
chains in the Genus database with same CATH topology
4BOQA 3W30A 3PRMA 1PVJA 2DOSA 5EZSA 3PSEA 4BOSA 3C0RA 1YZBA 2Z84A 2BTWA 3TRKA 4D8EA 3BBAA 3E9SA 4D8IA 5JZEA 3OQCA 3PHXA 3RNVA 3PRPA 4M0WA 4PT5A 4R3DA 2J7QC 5EZQA 2UZJA 2BU3A 4BOPA 4D8BA 4MM3B 4OVZB 2JTCA 3BB7A 4BOZA 3MTVA 3PT2A 4HXDB 3W31A 4IP3A 4XZXA 2FE8A 3TMPA 4WURA 4BOUA 5E6JA 4P16A 3O65A 2JRIA 3PHUA 3MP2A 2AGAA 3B21A 4OW0A 4RF0A 4RF1A 1DKIA 4MI7A 4REZA 4OVZA 4A5UA 4ZTBA 2J7QA 3ZNHA 5KO3A 4RNAA 3PHWA 2HWKA 4RKXA 2BTWB 4IUMA 3MJ5A 3BY4A 3IFUA 4GUAA 1UKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J7Q A;  2J7Q C; 
#chains in the Genus database with same CATH topology
 4PP2 E;  1CV8 A;  1CVZ A;  1ZIV A;  4BS5 A;  3DF0 A;  2PBH A;  1PPO A;  3PRM A;  1CSB B;  5EZS A;  4CDE B;  3MHS A;  4BOS A;  4YYR A;  3KX1 A;  2YJ9 A;  4XUI A;  2DCA A;  4N4Z A;  3TRK A;  1CQD A;  3BBA A;  4D8I A;  1NB5 A;  5JZE A;  2XU4 A;  3USV A;  2R6N A;  1PCI A;  1CB5 A;  2JQF R;  1U9V A;  4YYS A;  3BPM A;  4KLB A;  4PT5 A;  3E1Z B;  3IEJ A;  2Y6E A;  2IBI A;  4RY2 A;  3O0U A;  3V6C A;  2DJG B;  5CVM A;  4D8B A;  2XU5 A;  3H7D A;  2JTC A;  3C9E A;  5JA7 A;  2FTD A;  3HHA A;  2O6X A;  4X6H A;  3PT2 A;  4YYQ A;  2DCB A;  1TLO A;  4IP3 A;  2DCD A;  4WUR A;  3BOW A;  3S3Q A;  4W4U A;  3I06 A;  3KFQ A;  4QRV A;  2PRE A;  4P16 A;  2R9N A;  3O65 A;  1GCB A;  8PCH A;  4MZS A;  3PHU A;  3S3R A;  3WXF A;  2E00 A;  2XU3 A;  2FT2 A;  2OUL A;  3MOR A;  1AU2 A;  1CJL A;  4RF1 A;  1M6D A;  4AXL A;  4MI7 A;  2YJB A;  1CS8 A;  3KWZ A;  4OVZ A;  3OVZ A;  1CPJ A;  5JH3 A;  5CVO B;  3ZNH A;  1QXP A;  4W5B A;  4CZW A;  4MZO A;  5KO3 A;  3TNX A;  2DC7 A;  3D6S A;  1EF7 A;  1ATK A;  4RKX A;  3IUT A;  2BTW B;  2VHF A;  1MEM A;  2WBF X;  2F7D A;  3IFU A;  3H8B A;  1F29 A;  1PPN A;  1U9X A;  2Y5B A;  3QJ3 A;  2DOS A;  1EWL A;  1YZB A;  2Z84 A;  1XKG A;  1Q6K A;  2AS8 A;  3H89 A;  4Q8G A;  7PCK A;  1YK7 A;  2AUX A;  3OQC A;  4OEM A;  4P6G A;  4PAD A;  2GFO A;  1KHQ A;  1F2C A;  1AYV A;  3KKU A;  3RVX A;  2J7Q C;  1IWD A;  5EZQ A;  3MTN A;  4MSX A;  4BOP A;  3NHE A;  4Q8H A;  2FO5 A;  1EWO A;  3WXE A;  4OVZ B;  1QOL A;  1PE6 A;  3BB7 A;  5F02 A;  3KSE A;  4DMY A;  1F2A A;  4G54 A;  4HXD B;  3OF9 A;  1HUC B;  2BDZ A;  1Y08 A;  3W31 A;  4CDF B;  3F5V A;  1AYW A;  1KHP A;  3HHI A;  2FE8 A;  2R9C A;  3TMP A;  4HWY A;  4BOU A;  3GCB A;  1AU0 A;  2E01 A;  2P86 A;  1BQI A;  1NL6 A;  1PPD A;  4DMX A;  1DEU A;  1SP4 B;  1Y4H A;  3K24 A;  3QSD A;  3U8E A;  4FK5 A;  2AGA A;  4BS6 A;  5FPW A;  3PDF A;  1AEC A;  1DF0 A;  4QRX A;  2FRA A;  1BGO A;  1DKI A;  3PNR A;  2P0R A;  1ITO A;  1YAL A;  3V6E A;  4A5U A;  4XR7 A;  2NQA A;  2HD5 A;  1S4V A;  2YJC A;  2YJ2 A;  4FJC A;  3CH3 X;  2G7Y A;  2NQG A;  2FRQ A;  3PHW A;  2F1G A;  3OVX A;  4BPV A;  1MEG A;  4PI3 A;  5EGW A;  1NLJ A;  3MJ5 A;  1PXV A;  1TL9 A;  3BY4 A;  1KFX L;  3W30 A;  4AXM A;  3AI8 A;  1PIP A;  1PVJ A;  5CHT A;  4CDD B;  1NPZ A;  1YT7 A;  3PSE A;  3RVV A;  1GLO A;  2G6D A;  1QMY A;  1ME3 A;  3KWB X;  4I04 A;  4YYW A;  1K3B B;  1FH0 A;  5EF4 A;  4P6E A;  4D8E A;  2CB5 A;  1ZCM A;  1YK8 A;  3P5W A;  1MS6 A;  4WA6 A;  2ARY A;  2DC8 A;  3IOQ A;  3B79 A;  4W5C A;  3RNV A;  3K8U A;  3QT4 A;  4M0W A;  4R3D A;  2CIO A;  2HHN A;  3ZUA A;  2UZJ A;  4YYV A;  4MM3 B;  4CDC B;  2DC6 A;  3IMA A;  1TU6 A;  2PNS A;  2B1N A;  4FIP A;  2G8E A;  3M99 A;  3N4C A;  5J94 A;  1VJV A;  1F2B A;  2NQD B;  2IPP B;  1UKF A;  1U9W A;  3F75 A;  2C0Y A;  2AUZ A;  2DC9 A;  1AU4 A;  1VSN A;  4XZX A;  3OF8 A;  1X9Y A;  1EWP A;  1U5I A;  2H7J A;  5E6J A;  2XU1 A;  1THE A;  4I05 A;  4X6J A;  1STF E;  2DZZ A;  4QRG A;  3HD3 A;  3MP2 A;  3B21 A;  1SNK A;  3P5U A;  4QBB A;  3H6S A;  4YV8 A;  3BC3 A;  4RF0 A;  2P7U A;  2ACT A;  4REZ A;  1KFU L;  1EWM A;  1O0E A;  3I3T A;  2FQ9 A;  3H8C A;  1YVB A;  2ATO A;  2DJF B;  3IHP A;  6PAD A;  1BY8 A;  3OIS A;  1PAD A;  4BOQ A;  3CBJ A;  2PAD A;  3ERV A;  2OZ2 A;  2R9O A;  3C0R A;  3CH2 X;  1AU3 A;  1GMY A;  3CBK A;  2BTW A;  1QDQ A;  2FUD A;  1PPP A;  4YVA A;  3E9S A;  1MHW A;  3K9M A;  1AYU A;  4N8W A;  4PP1 A;  2R9F A;  3PHX A;  1ME4 A;  3P5V A;  2NQI A;  1AIM A;  3PRP A;  2YJ8 A;  1A6R A;  2HXZ A;  3KW9 A;  2AVW A;  3N3G A;  2BU3 A;  2VHS A;  2B1M A;  4OEL A;  2AYO A;  2R9M A;  3RVW A;  4BOZ A;  1NQC A;  4BQV A;  4BSQ A;  3MTV A;  1MDW A;  1PBH A;  1NB3 A;  3WXG A;  2E02 A;  2AU1 A;  2OP3 A;  3IV2 A;  4I07 A;  3N3K A;  4YYU A;  4N79 A;  5A24 A;  2G8J A;  1CTE A;  1U9Q X;  1GEC E;  2JQG R;  3BCN A;  1BP4 A;  2DZY A;  2JRI A;  4K7C A;  1JQP A;  3HWN A;  2E03 A;  3LFY A;  4X6I A;  4OW0 A;  5K16 A;  3O1G A;  2DCC A;  3LXS A;  1KXR A;  2GHU A;  3PW3 A;  2HH5 A;  1ICF A;  5CHV A;  2BDL A;  4QH6 A;  4ZTB A;  3MHH A;  2J7Q A;  2AYN A;  3BWK A;  9PAP A;  4RNA A;  2AIM A;  3P5X A;  2FYE A;  1MIR A;  2HWK A;  5PAD A;  4ZUX U;  3PBH A;  4IUM A;  3BPF A;  5CVN B;  4GUA A;  1POP A; 
#chains in the Genus database with same CATH homology
 4BOQ A;  3W30 A;  3PRM A;  1PVJ A;  2DOS A;  5EZS A;  3PSE A;  4BOS A;  3C0R A;  1YZB A;  2Z84 A;  2BTW A;  3TRK A;  4D8E A;  3BBA A;  3E9S A;  4D8I A;  5JZE A;  3OQC A;  3PHX A;  3RNV A;  3PRP A;  4M0W A;  4PT5 A;  4R3D A;  2J7Q C;  5EZQ A;  2UZJ A;  2BU3 A;  4BOP A;  4D8B A;  4MM3 B;  4OVZ B;  2JTC A;  3BB7 A;  4BOZ A;  3MTV A;  3PT2 A;  4HXD B;  3W31 A;  4IP3 A;  4XZX A;  2FE8 A;  3TMP A;  4WUR A;  4BOU A;  5E6J A;  4P16 A;  3O65 A;  2JRI A;  3PHU A;  3MP2 A;  2AGA A;  3B21 A;  4OW0 A;  4RF0 A;  4RF1 A;  1DKI A;  4MI7 A;  4REZ A;  4OVZ A;  4A5U A;  4ZTB A;  2J7Q A;  3ZNH A;  5KO3 A;  4RNA A;  3PHW A;  2HWK A;  4RKX A;  2BTW B;  4IUM A;  3MJ5 A;  3BY4 A;  3IFU A;  4GUA A;  1UKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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