1MDWA

Crystal structure of calcium-bound protease core of calpain ii reveals the basis for intrinsic inactivation
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
323
structure length
319
Chain Sequence
b'ERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDSWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Calpain II, catalytic subunit
publication title Calpain silencing by a reversible intrinsic mechanism.
pubmed doi rcsb
source organism Rattus norvegicus
molecule tags Hydrolase
total genus 94
structure length 319
sequence length 323
chains with identical sequence B
ec nomenclature ec 3.4.22.53: Calpain-2.
pdb deposition date 2002-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00648 Peptidase_C2 Calpain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1mdwA02
3BPMA 4CDEB 1QDQA 3BOWA 2E00A 2YJ9A 4XUIA 1QXPA 1EWPA 4Q8HA 1KHPA 4YYRA 2JQGR 4KLBA 2DZYA 1MDWA 2FTDA 3OISA 2YJ2A 1NB3A 3IOQA 1CSBB 2DCCA 4XR7A 1PE6A 1CPJA 2R9MA 1NPZA 4BS5A 1EWMA 1TL9A 4HWYA 1CB5A 3H8CA 4CZWA 2FQ9A 2G7YA 3KFQA 1ME4A 5PADA 3GCBA 1ATKA 2YJ8A 4OEMA 5CVOB 1EWLA 1EF7A 2R9CA 3O1GA 1MHWA 1EWOA 4W4UA 4I04A 4QRXA 1K3BB 2NQDB 3I06A 4CDDB 1THEA 3MTNA 3U8EA 3HHAA 1ME3A 1AYUA 5CVMA 3WXFA 5F02A 2XU3A 3H6SA 1SP4B 1AYVA 2HHNA 2B1NA 3D6SA 2BDLA 3N4CA 2WBFX 2DCDA 2XU4A 3K9MA 3N3KA 2DC6A 8PCHA 4BS6A 1JQPA 2NQAA 2E02A 3OF9A 5CHVA 4CDFB 1VJVA 5EGWA 4YVAA 4RY2A 4QBBA 2OULA 1GCBA 3MORA 4X6JA 4BQVA 4YYUA 2FRAA 1PPDA 4DMYA 2NQGA 4P6GA 2HD5A 4QRVA 2ATOA 9PAPA 2DC7A 1PPOA 1Y4HA 3KWBX 3QSDA 5JA7A 2JQFR 1DF0A 3QT4A 1S4VA 1CVZA 2OZ2A 4QRGA 1IWDA 3BC3A 1YVBA 3CBJA 1MEGA 3CBKA 3IMAA 3C9EA 1YALA 3F5VA 3NHEA 2AVWA 4YYVA 2BDZA 3IV2A 1BQIA 2AUXA 3IUTA 2PREA 2YJCA 3E1ZB 2DC8A 4K7CA 4PADA 2DC9A 4X6HA 4N8WA 4W5CA 3S3RA 1F2BA 4N4ZA 1F2CA 2GFOA 2IBIA 1PADA 3P5XA 3WXGA 1F2AA 4FIPA 2G8JA 1O0EA 1AIMA 1CV8A 3CH2X 2XU5A 3HWNA 5K16A 3PBHA 4DMXA 1NLJA 1CTEA 3K24A 3WXEA 1QOLA 3AI8A 1AU2A 2PADA 3KW9A 3OVZA 2CB5A 1GLOA 4AXLA 2OP3A 1BY8A 1KXRA 2R6NA 4BSQA 2C0YA 1M6DA 2R9NA 2FYEA 3TNXA 4CDCB 2DCBA 1ITOA 2P0RA 2AU1A 4PI3A 3PNRA 3B79A 3KX1A 2PNSA 1VSNA 2IPPB 4YYWA 3O0UA 4OELA 3S3QA 4BPVA 1KFXL 3PDFA 7PCKA 3LFYA 1HUCB 1NQCA 4QH6A 1AYWA 1SNKA 1NB5A 1U9QX 1DEUA 3M99A 1YK8A 5CVNB 4G54A 3HHIA 2PBHA 2P86A 3BWKA 2ARYA 5JH3A 2E01A 2AYNA 3CH3X 3KSEA 2G6DA 2F7DA 6PADA 3ERVA 1POPA 4Q8GA 1AU0A 2DZZA 1GECE 2XU1A 2AIMA 1PPNA 2Y5BA 2HXZA 1XKGA 4X6IA 1NL6A 4FK5A 1CS8A 2AUZA 4AXMA 4YYQA 1MIRA 5EF4A 4MSXA 5J94A 1YK7A 4I05A 2HH5A 1BGOA 3IEJA 3N3GA 3HD3A 3I3TA 3DF0A 3IHPA 3KKUA 3OF8A 1Q6KA 5A24A 3H7DA 3QJ3A 3K8UA 4P6EA 2F1GA 3MHHA 3RVXA 2GHUA 3PW3A 1TU6A 3RVWA 1F29A 4MZOA 2B1MA 3V6CA 1U9XA 2P7UA 4I07A 1KFUL 1TLOA 4MZSA 1CJLA 2VHFA 2DJFB 3BCNA 1U9VA 3LXSA 2DJGB 1PIPA 4ZUXU 1X9YA 1BP4A 2Y6EA 4W5BA 1PCIA 4WA6A 1FH0A 1CQDA 1PXVA 1U5IA 4FJCA 2FUDA 2O6XA 2R9FA 1PPPA 1YT7A 2VHSA 2AYOA 1STFE 3RVVA 3KWZA 2DCAA 3H8BA 2R9OA 1ZIVA 5FPWA 3MHSA 1MS6A 4PP2E 3P5WA 5CHTA 2FO5A 2FT2A 1KHQA 1MEMA 4YV8A 1AU3A 3BPFA 2CIOA 1Y08A 1ZCMA 3P5VA 2E03A 1AU4A 2FRQA 1PBHA 4N79A 2G8EA 3V6EA 3OVXA 1AECA 3P5UA 4PP1A 2ACTA 1A6RA 2YJBA 1ICFA 4YYSA 3USVA 2NQIA 3ZUAA 1QMYA 2AS8A 3F75A 2H7JA 1GMYA 1U9WA 3H89A
chains in the Genus database with same CATH superfamily
4RF0A 3BPMA 4CDEB 1QDQA 3BOWA 2E00A 2YJ9A 4XUIA 1QXPA 1EWPA 4Q8HA 3W31A 3PRPA 4RF1A 1KHPA 4YYRA 2JQGR 4HXDB 4KLBA 4RNAA 2DZYA 4D8BA 1MDWA 2FTDA 3OISA 2YJ2A 1NB3A 3IOQA 1CSBB 2DCCA 4XR7A 1PE6A 1CPJA 2R9MA 1NPZA 4BS5A 1EWMA 1TL9A 4HWYA 1CB5A 2BTWA 3H8CA 4CZWA 2FQ9A 2G7YA 3KFQA 1ME4A 5PADA 3GCBA 1ATKA 2YJ8A 4OEMA 5CVOB 1EWLA 1EF7A 3O1GA 2R9CA 2JTCA 1MHWA 1EWOA 4W4UA 4I04A 4QRXA 1K3BB 2NQDB 3I06A 4MI7A 4CDDB 1THEA 3MTNA 3U8EA 2J7QA 3HHAA 1ME3A 1AYUA 5E6JA 5CVMA 3WXFA 5F02A 2XU3A 3H6SA 1SP4B 5KO3A 1AYVA 2HHNA 2B1NA 3D6SA 3ZNHA 4M0WA 2BDLA 3N4CA 4D8IA 2WBFX 2DCDA 2XU4A 3PHXA 3K9MA 3N3KA 2DOSA 2DC6A 8PCHA 4BS6A 1JQPA 3C0RA 2NQAA 2E02A 3OF9A 5CHVA 4CDFB 1VJVA 5EGWA 3BY4A 4YVAA 4RY2A 4QBBA 2OULA 1GCBA 3MORA 4X6JA 4BQVA 4YYUA 2FRAA 1PPDA 2BU3A 4DMYA 2NQGA 4P6GA 2HD5A 4QRVA 2ATOA 9PAPA 2DC7A 1PPOA 1Y4HA 3KWBX 3QSDA 5JA7A 2JQFR 1DF0A 3QT4A 1S4VA 1CVZA 2OZ2A 3W30A 4QRGA 1IWDA 3BC3A 1YVBA 3CBJA 1MEGA 3TRKA 3CBKA 3IMAA 4ZTBA 3C9EA 1YALA 3F5VA 3NHEA 2AVWA 3TMPA 4YYVA 2BDZA 3IV2A 1BQIA 2AGAA 2AUXA 3IUTA 2PREA 2YJCA 3E1ZB 2DC8A 4K7CA 4PADA 2DC9A 3E9SA 3BB7A 4X6HA 4N8WA 3MJ5A 3OQCA 4W5CA 3S3RA 1F2BA 4N4ZA 1F2CA 2GFOA 4MM3B 4R3DA 2IBIA 1PADA 3P5XA 3WXGA 1F2AA 4FIPA 2G8JA 1O0EA 1AIMA 4OW0A 1CV8A 3CH2X 4BOSA 2XU5A 3HWNA 5K16A 3PHUA 3PBHA 4DMXA 1NLJA 1CTEA 3K24A 3WXEA 3BBAA 1QOLA 4OVZA 3AI8A 1AU2A 2PADA 2Z84A 3KW9A 3OVZA 2CB5A 1GLOA 4PT5A 4AXLA 1DKIA 2OP3A 1BY8A 1KXRA 2R6NA 4BSQA 2C0YA 1M6DA 2R9NA 2FYEA 3TNXA 4CDCB 2DCBA 1ITOA 2P0RA 2AU1A 4PI3A 3PNRA 3B79A 3KX1A 2PNSA 1VSNA 2IPPB 4YYWA 3O0UA 4RKXA 4OELA 3PT2A 3O65A 5EZSA 3S3QA 4BPVA 1KFXL 3PDFA 7PCKA 3LFYA 1HUCB 1NQCA 4QH6A 5JZEA 1AYWA 1SNKA 1NB5A 1U9QX 1DEUA 3M99A 1YK8A 5CVNB 4G54A 3HHIA 3MTVA 2PBHA 2P86A 3BWKA 4WURA 2BTWB 2ARYA 5JH3A 2E01A 2AYNA 3CH3X 3KSEA 2G6DA 2F7DA 6PADA 3ERVA 1POPA 3IFUA 4Q8GA 1AU0A 4GUAA 2DZZA 3PSEA 1YZBA 1GECE 2XU1A 2AIMA 1PPNA 2Y5BA 2HXZA 3B21A 1XKGA 4XZXA 2UZJA 4X6IA 2J7QC 1NL6A 4FK5A 1CS8A 2AUZA 4AXMA 4YYQA 1MIRA 5EF4A 4MSXA 5J94A 1YK7A 3PHWA 4I05A 4OVZB 2HH5A 1BGOA 3IEJA 3N3GA 3HD3A 2JRIA 4BOPA 3I3TA 3DF0A 3IHPA 3KKUA 3OF8A 1Q6KA 5A24A 3H7DA 3QJ3A 3K8UA 2F1GA 3MHHA 4P6EA 3RVXA 2GHUA 3PW3A 1TU6A 3RVWA 1F29A 4MZOA 2B1MA 3V6CA 1U9XA 2P7UA 4P16A 4I07A 1KFUL 1TLOA 4MZSA 1CJLA 4IUMA 2VHFA 4BOQA 2DJFB 3BCNA 1U9VA 3LXSA 2DJGB 1PIPA 4ZUXU 1X9YA 1BP4A 2Y6EA 4W5BA 1PCIA 3PRMA 4WA6A 1UKFA 1FH0A 1CQDA 1PXVA 1U5IA 4FJCA 2FUDA 2O6XA 2R9FA 1PPPA 1YT7A 2VHSA 2AYOA 1STFE 5EZQA 3RVVA 3KWZA 4IP3A 2DCAA 3H8BA 2R9OA 1ZIVA 5FPWA 3MHSA 1MS6A 1PVJA 4D8EA 4PP2E 3P5WA 5CHTA 2FO5A 2FT2A 1KHQA 3RNVA 1MEMA 4YV8A 1AU3A 3BPFA 2CIOA 4BOZA 1Y08A 3MP2A 1ZCMA 3P5VA 4BOUA 2E03A 1AU4A 2FRQA 1PBHA 4N79A 4REZA 2G8EA 3V6EA 3OVXA 1AECA 3P5UA 4PP1A 2ACTA 1A6RA 2YJBA 1ICFA 4YYSA 3USVA 2NQIA 3ZUAA 2FE8A 1QMYA 2AS8A 3F75A 2H7JA 4A5UA 2HWKA 1GMYA 1U9WA 3H89A
chains in the Genus database with same CATH topology
3BPMA 4CDEB 1QDQA 3BOWA 2E00A 2YJ9A 4XUIA 1QXPA 1EWPA 4Q8HA 1KHPA 4YYRA 2JQGR 4KLBA 2DZYA 1MDWA 2FTDA 3OISA 2YJ2A 1NB3A 3IOQA 1CSBB 2DCCA 4XR7A 1PE6A 1CPJA 2R9MA 1NPZA 4BS5A 1EWMA 1TL9A 1W4TA 4HWYA 1CB5A 3H8CA 4CZWA 2FQ9A 2G7YA 3KFQA 1ME4A 5PADA 3GCBA 1ATKA 2YJ8A 4OEMA 5CVOB 1EWLA 1EF7A 2R9CA 3O1GA 1MHWA 1EWOA 4GUZA 4W4UA 4I04A 2VFCA 4QRXA 1K3BB 2NQDB 3I06A 4CDDB 1THEA 3MTNA 3U8EA 3HHAA 1ME3A 1AYUA 5CVMA 3LTWA 3WXFA 5F02A 2XU3A 3H6SA 1SP4B 1AYVA 2HHNA 2B1NA 3D6SA 2BDLA 3N4CA 2WBFX 2DCDA 2XU4A 2BSZA 3K9MA 3N3KA 2DC6A 8PCHA 4BS6A 4NV7A 1JQPA 2NQAA 2E02A 3OF9A 5CHVA 4CDFB 1VJVA 5EGWA 4YVAA 4RY2A 4QBBA 2OULA 1GCBA 3MORA 4X6JA 4BQVA 4YYUA 2FRAA 1PPDA 4DMYA 2NQGA 4P6GA 2HD5A 4QRVA 2ATOA 9PAPA 2DC7A 1PPOA 1Y4HA 3KWBX 3QSDA 5JA7A 1W5RA 2JQFR 1DF0A 3QT4A 1S4VA 1CVZA 2OZ2A 4QRGA 1IWDA 3BC3A 1YVBA 3CBJA 1MEGA 3CBKA 2VFBA 3IMAA 3C9EA 1YALA 3F5VA 3NHEA 2AVWA 4YYVA 2BDZA 3IV2A 1BQIA 4B55A 2AUXA 3IUTA 2PREA 2YJCA 3E1ZB 2DC8A 4K7CA 4PADA 2DC9A 4X6HA 4N8WA 4W5CA 3S3RA 1F2BA 4N4ZA 1F2CA 2GFOA 2IBIA 1PADA 3P5XA 3WXGA 1F2AA 4FIPA 2G8JA 1O0EA 1AIMA 3D9WA 1CV8A 3CH2X 2XU5A 3HWNA 5K16A 3PBHA 4DMXA 1NLJA 1CTEA 3K24A 3WXEA 1QOLA 3AI8A 1AU2A 2PADA 1W6FA 3KW9A 3OVZA 2CB5A 1GLOA 4AXLA 2OP3A 1BY8A 1KXRA 2R6NA 4BSQA 2C0YA 1M6DA 2R9NA 2FYEA 3TNXA 4CDCB 2DCBA 1ITOA 2P0RA 2AU1A 4PI3A 3PNRA 3B79A 3KX1A 2PNSA 1VSNA 2IPPB 4YYWA 3O0UA 4OELA 3S3QA 4BPVA 1KFXL 3PDFA 7PCKA 3LFYA 1HUCB 1NQCA 4QH6A 1AYWA 1SNKA 1NB5A 1U9QX 1DEUA 3M99A 1YK8A 5CVNB 4G54A 3HHIA 2PBHA 2P86A 3BWKA 2ARYA 5JH3A 2E01A 2AYNA 3CH3X 3KSEA 2G6DA 2F7DA 6PADA 3ERVA 1POPA 4Q8GA 1AU0A 2DZZA 1GECE 2XU1A 2AIMA 1PPNA 2Y5BA 2HXZA 1XKGA 4X6IA 1NL6A 4FK5A 1CS8A 2AUZA 4AXMA 4YYQA 1MIRA 5EF4A 4MSXA 5J94A 1YK7A 4I05A 2HH5A 1BGOA 3IEJA 3N3GA 3HD3A 3I3TA 3DF0A 3IHPA 3KKUA 3OF8A 1Q6KA 5A24A 3H7DA 1E2TA 3QJ3A 3K8UA 2F1GA 3MHHA 4P6EA 3RVXA 2GHUA 3PW3A 1TU6A 3RVWA 1F29A 4MZOA 2B1MA 3V6CA 1U9XA 2P7UA 4I07A 1KFUL 1TLOA 4MZSA 1CJLA 2VHFA 2DJFB 3BCNA 1U9VA 3LXSA 2DJGB 1PIPA 4ZUXU 1X9YA 1BP4A 2Y6EA 4W5BA 1PCIA 4WA6A 1FH0A 1CQDA 1PXVA 1U5IA 4FJCA 4BGFA 2FUDA 2O6XA 2R9FA 1PPPA 1YT7A 2VHSA 2AYOA 1STFE 4C5PA 3RVVA 3KWZA 2DCAA 3H8BA 2R9OA 1ZIVA 5FPWA 4NV8A 3MHSA 1MS6A 4PP2E 3P5WA 5CHTA 2FO5A 2FT2A 1KHQA 1MEMA 4YV8A 1AU3A 3BPFA 2CIOA 1Y08A 1ZCMA 3P5VA 2E03A 1AU4A 2FRQA 1PBHA 4N79A 2G8EA 3V6EA 3OVXA 1AECA 3P5UA 4PP1A 1GX3A 2ACTA 1A6RA 2YJBA 1ICFA 4YYSA 3USVA 2NQIA 3ZUAA 1QMYA 2AS8A 3F75A 2H7JA 1GMYA 1U9WA 3H89A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BPM A;  4CDE B;  1QDQ A;  3BOW A;  2E00 A;  2YJ9 A;  4XUI A;  1QXP A;  1EWP A;  4Q8H A;  1KHP A;  4YYR A;  2JQG R;  4KLB A;  2DZY A;  1MDW A;  2FTD A;  3OIS A;  2YJ2 A;  1NB3 A;  3IOQ A;  1CSB B;  2DCC A;  4XR7 A;  1PE6 A;  1CPJ A;  2R9M A;  1NPZ A;  4BS5 A;  1EWM A;  1TL9 A;  4HWY A;  1CB5 A;  3H8C A;  4CZW A;  2FQ9 A;  2G7Y A;  3KFQ A;  1ME4 A;  5PAD A;  3GCB A;  1ATK A;  2YJ8 A;  4OEM A;  5CVO B;  1EWL A;  1EF7 A;  2R9C A;  3O1G A;  1MHW A;  1EWO A;  4W4U A;  4I04 A;  4QRX A;  1K3B B;  2NQD B;  3I06 A;  4CDD B;  1THE A;  3MTN A;  3U8E A;  3HHA A;  1ME3 A;  1AYU A;  5CVM A;  3WXF A;  5F02 A;  2XU3 A;  3H6S A;  1SP4 B;  1AYV A;  2HHN A;  2B1N A;  3D6S A;  2BDL A;  3N4C A;  2WBF X;  2DCD A;  2XU4 A;  3K9M A;  3N3K A;  2DC6 A;  8PCH A;  4BS6 A;  1JQP A;  2NQA A;  2E02 A;  3OF9 A;  5CHV A;  4CDF B;  1VJV A;  5EGW A;  4YVA A;  4RY2 A;  4QBB A;  2OUL A;  1GCB A;  3MOR A;  4X6J A;  4BQV A;  4YYU A;  2FRA A;  1PPD A;  4DMY A;  2NQG A;  4P6G A;  2HD5 A;  4QRV A;  2ATO A;  9PAP A;  2DC7 A;  1PPO A;  1Y4H A;  3KWB X;  3QSD A;  5JA7 A;  2JQF R;  1DF0 A;  3QT4 A;  1S4V A;  1CVZ A;  2OZ2 A;  4QRG A;  1IWD A;  3BC3 A;  1YVB A;  3CBJ A;  1MEG A;  3CBK A;  3IMA A;  3C9E A;  1YAL A;  3F5V A;  3NHE A;  2AVW A;  4YYV A;  2BDZ A;  3IV2 A;  1BQI A;  2AUX A;  3IUT A;  2PRE A;  2YJC A;  3E1Z B;  2DC8 A;  4K7C A;  4PAD A;  2DC9 A;  4X6H A;  4N8W A;  4W5C A;  3S3R A;  1F2B A;  4N4Z A;  1F2C A;  2GFO A;  2IBI A;  1PAD A;  3P5X A;  3WXG A;  1F2A A;  4FIP A;  2G8J A;  1O0E A;  1AIM A;  1CV8 A;  3CH2 X;  2XU5 A;  3HWN A;  5K16 A;  3PBH A;  4DMX A;  1NLJ A;  1CTE A;  3K24 A;  3WXE A;  1QOL A;  3AI8 A;  1AU2 A;  2PAD A;  3KW9 A;  3OVZ A;  2CB5 A;  1GLO A;  4AXL A;  2OP3 A;  1BY8 A;  1KXR A;  2R6N A;  4BSQ A;  2C0Y A;  1M6D A;  2R9N A;  2FYE A;  3TNX A;  4CDC B;  2DCB A;  1ITO A;  2P0R A;  2AU1 A;  4PI3 A;  3PNR A;  3B79 A;  3KX1 A;  2PNS A;  1VSN A;  2IPP B;  4YYW A;  3O0U A;  4OEL A;  3S3Q A;  4BPV A;  1KFX L;  3PDF A;  7PCK A;  3LFY A;  1HUC B;  1NQC A;  4QH6 A;  1AYW A;  1SNK A;  1NB5 A;  1U9Q X;  1DEU A;  3M99 A;  1YK8 A;  5CVN B;  4G54 A;  3HHI A;  2PBH A;  2P86 A;  3BWK A;  2ARY A;  5JH3 A;  2E01 A;  2AYN A;  3CH3 X;  3KSE A;  2G6D A;  2F7D A;  6PAD A;  3ERV A;  1POP A;  4Q8G A;  1AU0 A;  2DZZ A;  1GEC E;  2XU1 A;  2AIM A;  1PPN A;  2Y5B A;  2HXZ A;  1XKG A;  4X6I A;  1NL6 A;  4FK5 A;  1CS8 A;  2AUZ A;  4AXM A;  4YYQ A;  1MIR A;  5EF4 A;  4MSX A;  5J94 A;  1YK7 A;  4I05 A;  2HH5 A;  1BGO A;  3IEJ A;  3N3G A;  3HD3 A;  3I3T A;  3DF0 A;  3IHP A;  3KKU A;  3OF8 A;  1Q6K A;  5A24 A;  3H7D A;  3QJ3 A;  3K8U A;  4P6E A;  2F1G A;  3MHH A;  3RVX A;  2GHU A;  3PW3 A;  1TU6 A;  3RVW A;  1F29 A;  4MZO A;  2B1M A;  3V6C A;  1U9X A;  2P7U A;  4I07 A;  1KFU L;  1TLO A;  4MZS A;  1CJL A;  2VHF A;  2DJF B;  3BCN A;  1U9V A;  3LXS A;  2DJG B;  1PIP A;  4ZUX U;  1X9Y A;  1BP4 A;  2Y6E A;  4W5B A;  1PCI A;  4WA6 A;  1FH0 A;  1CQD A;  1PXV A;  1U5I A;  4FJC A;  2FUD A;  2O6X A;  2R9F A;  1PPP A;  1YT7 A;  2VHS A;  2AYO A;  1STF E;  3RVV A;  3KWZ A;  2DCA A;  3H8B A;  2R9O A;  1ZIV A;  5FPW A;  3MHS A;  1MS6 A;  4PP2 E;  3P5W A;  5CHT A;  2FO5 A;  2FT2 A;  1KHQ A;  1MEM A;  4YV8 A;  1AU3 A;  3BPF A;  2CIO A;  1Y08 A;  1ZCM A;  3P5V A;  2E03 A;  1AU4 A;  2FRQ A;  1PBH A;  4N79 A;  2G8E A;  3V6E A;  3OVX A;  1AEC A;  3P5U A;  4PP1 A;  2ACT A;  1A6R A;  2YJB A;  1ICF A;  4YYS A;  3USV A;  2NQI A;  3ZUA A;  1QMY A;  2AS8 A;  3F75 A;  2H7J A;  1GMY A;  1U9W A;  3H89 A; 
#chains in the Genus database with same CATH topology
 4RF0 A;  3BPM A;  4CDE B;  1QDQ A;  3BOW A;  2E00 A;  2YJ9 A;  4XUI A;  1QXP A;  1EWP A;  4Q8H A;  3W31 A;  3PRP A;  4RF1 A;  1KHP A;  4YYR A;  2JQG R;  4HXD B;  4KLB A;  4RNA A;  2DZY A;  4D8B A;  1MDW A;  2FTD A;  3OIS A;  2YJ2 A;  1NB3 A;  3IOQ A;  1CSB B;  2DCC A;  4XR7 A;  1PE6 A;  1CPJ A;  2R9M A;  1NPZ A;  4BS5 A;  1EWM A;  1TL9 A;  4HWY A;  1CB5 A;  2BTW A;  3H8C A;  4CZW A;  2FQ9 A;  2G7Y A;  3KFQ A;  1ME4 A;  5PAD A;  3GCB A;  1ATK A;  2YJ8 A;  4OEM A;  5CVO B;  1EWL A;  1EF7 A;  3O1G A;  2R9C A;  2JTC A;  1MHW A;  1EWO A;  4W4U A;  4I04 A;  4QRX A;  1K3B B;  2NQD B;  3I06 A;  4MI7 A;  4CDD B;  1THE A;  3MTN A;  3U8E A;  2J7Q A;  3HHA A;  1ME3 A;  1AYU A;  5E6J A;  5CVM A;  3WXF A;  5F02 A;  2XU3 A;  3H6S A;  1SP4 B;  5KO3 A;  1AYV A;  2HHN A;  2B1N A;  3D6S A;  3ZNH A;  4M0W A;  2BDL A;  3N4C A;  4D8I A;  2WBF X;  2DCD A;  2XU4 A;  3PHX A;  3K9M A;  3N3K A;  2DOS A;  2DC6 A;  8PCH A;  4BS6 A;  1JQP A;  3C0R A;  2NQA A;  2E02 A;  3OF9 A;  5CHV A;  4CDF B;  1VJV A;  5EGW A;  3BY4 A;  4YVA A;  4RY2 A;  4QBB A;  2OUL A;  1GCB A;  3MOR A;  4X6J A;  4BQV A;  4YYU A;  2FRA A;  1PPD A;  2BU3 A;  4DMY A;  2NQG A;  4P6G A;  2HD5 A;  4QRV A;  2ATO A;  9PAP A;  2DC7 A;  1PPO A;  1Y4H A;  3KWB X;  3QSD A;  5JA7 A;  2JQF R;  1DF0 A;  3QT4 A;  1S4V A;  1CVZ A;  2OZ2 A;  3W30 A;  4QRG A;  1IWD A;  3BC3 A;  1YVB A;  3CBJ A;  1MEG A;  3TRK A;  3CBK A;  3IMA A;  4ZTB A;  3C9E A;  1YAL A;  3F5V A;  3NHE A;  2AVW A;  3TMP A;  4YYV A;  2BDZ A;  3IV2 A;  1BQI A;  2AGA A;  2AUX A;  3IUT A;  2PRE A;  2YJC A;  3E1Z B;  2DC8 A;  4K7C A;  4PAD A;  2DC9 A;  3E9S A;  3BB7 A;  4X6H A;  4N8W A;  3MJ5 A;  3OQC A;  4W5C A;  3S3R A;  1F2B A;  4N4Z A;  1F2C A;  2GFO A;  4MM3 B;  4R3D A;  2IBI A;  1PAD A;  3P5X A;  3WXG A;  1F2A A;  4FIP A;  2G8J A;  1O0E A;  1AIM A;  4OW0 A;  1CV8 A;  3CH2 X;  4BOS A;  2XU5 A;  3HWN A;  5K16 A;  3PHU A;  3PBH A;  4DMX A;  1NLJ A;  1CTE A;  3K24 A;  3WXE A;  3BBA A;  1QOL A;  4OVZ A;  3AI8 A;  1AU2 A;  2PAD A;  2Z84 A;  3KW9 A;  3OVZ A;  2CB5 A;  1GLO A;  4PT5 A;  4AXL A;  1DKI A;  2OP3 A;  1BY8 A;  1KXR A;  2R6N A;  4BSQ A;  2C0Y A;  1M6D A;  2R9N A;  2FYE A;  3TNX A;  4CDC B;  2DCB A;  1ITO A;  2P0R A;  2AU1 A;  4PI3 A;  3PNR A;  3B79 A;  3KX1 A;  2PNS A;  1VSN A;  2IPP B;  4YYW A;  3O0U A;  4RKX A;  4OEL A;  3PT2 A;  3O65 A;  5EZS A;  3S3Q A;  4BPV A;  1KFX L;  3PDF A;  7PCK A;  3LFY A;  1HUC B;  1NQC A;  4QH6 A;  5JZE A;  1AYW A;  1SNK A;  1NB5 A;  1U9Q X;  1DEU A;  3M99 A;  1YK8 A;  5CVN B;  4G54 A;  3HHI A;  3MTV A;  2PBH A;  2P86 A;  3BWK A;  4WUR A;  2BTW B;  2ARY A;  5JH3 A;  2E01 A;  2AYN A;  3CH3 X;  3KSE A;  2G6D A;  2F7D A;  6PAD A;  3ERV A;  1POP A;  3IFU A;  4Q8G A;  1AU0 A;  4GUA A;  2DZZ A;  3PSE A;  1YZB A;  1GEC E;  2XU1 A;  2AIM A;  1PPN A;  2Y5B A;  2HXZ A;  3B21 A;  1XKG A;  4XZX A;  2UZJ A;  4X6I A;  2J7Q C;  1NL6 A;  4FK5 A;  1CS8 A;  2AUZ A;  4AXM A;  4YYQ A;  1MIR A;  5EF4 A;  4MSX A;  5J94 A;  1YK7 A;  3PHW A;  4I05 A;  4OVZ B;  2HH5 A;  1BGO A;  3IEJ A;  3N3G A;  3HD3 A;  2JRI A;  4BOP A;  3I3T A;  3DF0 A;  3IHP A;  3KKU A;  3OF8 A;  1Q6K A;  5A24 A;  3H7D A;  3QJ3 A;  3K8U A;  2F1G A;  3MHH A;  4P6E A;  3RVX A;  2GHU A;  3PW3 A;  1TU6 A;  3RVW A;  1F29 A;  4MZO A;  2B1M A;  3V6C A;  1U9X A;  2P7U A;  4P16 A;  4I07 A;  1KFU L;  1TLO A;  4MZS A;  1CJL A;  4IUM A;  2VHF A;  4BOQ A;  2DJF B;  3BCN A;  1U9V A;  3LXS A;  2DJG B;  1PIP A;  4ZUX U;  1X9Y A;  1BP4 A;  2Y6E A;  4W5B A;  1PCI A;  3PRM A;  4WA6 A;  1UKF A;  1FH0 A;  1CQD A;  1PXV A;  1U5I A;  4FJC A;  2FUD A;  2O6X A;  2R9F A;  1PPP A;  1YT7 A;  2VHS A;  2AYO A;  1STF E;  5EZQ A;  3RVV A;  3KWZ A;  4IP3 A;  2DCA A;  3H8B A;  2R9O A;  1ZIV A;  5FPW A;  3MHS A;  1MS6 A;  1PVJ A;  4D8E A;  4PP2 E;  3P5W A;  5CHT A;  2FO5 A;  2FT2 A;  1KHQ A;  3RNV A;  1MEM A;  4YV8 A;  1AU3 A;  3BPF A;  2CIO A;  4BOZ A;  1Y08 A;  3MP2 A;  1ZCM A;  3P5V A;  4BOU A;  2E03 A;  1AU4 A;  2FRQ A;  1PBH A;  4N79 A;  4REZ A;  2G8E A;  3V6E A;  3OVX A;  1AEC A;  3P5U A;  4PP1 A;  2ACT A;  1A6R A;  2YJB A;  1ICF A;  4YYS A;  3USV A;  2NQI A;  3ZUA A;  2FE8 A;  1QMY A;  2AS8 A;  3F75 A;  2H7J A;  4A5U A;  2HWK A;  1GMY A;  1U9W A;  3H89 A; 
#chains in the Genus database with same CATH homology
 3BPM A;  4CDE B;  1QDQ A;  3BOW A;  2E00 A;  2YJ9 A;  4XUI A;  1QXP A;  1EWP A;  4Q8H A;  1KHP A;  4YYR A;  2JQG R;  4KLB A;  2DZY A;  1MDW A;  2FTD A;  3OIS A;  2YJ2 A;  1NB3 A;  3IOQ A;  1CSB B;  2DCC A;  4XR7 A;  1PE6 A;  1CPJ A;  2R9M A;  1NPZ A;  4BS5 A;  1EWM A;  1TL9 A;  1W4T A;  4HWY A;  1CB5 A;  3H8C A;  4CZW A;  2FQ9 A;  2G7Y A;  3KFQ A;  1ME4 A;  5PAD A;  3GCB A;  1ATK A;  2YJ8 A;  4OEM A;  5CVO B;  1EWL A;  1EF7 A;  2R9C A;  3O1G A;  1MHW A;  1EWO A;  4GUZ A;  4W4U A;  4I04 A;  2VFC A;  4QRX A;  1K3B B;  2NQD B;  3I06 A;  4CDD B;  1THE A;  3MTN A;  3U8E A;  3HHA A;  1ME3 A;  1AYU A;  5CVM A;  3LTW A;  3WXF A;  5F02 A;  2XU3 A;  3H6S A;  1SP4 B;  1AYV A;  2HHN A;  2B1N A;  3D6S A;  2BDL A;  3N4C A;  2WBF X;  2DCD A;  2XU4 A;  2BSZ A;  3K9M A;  3N3K A;  2DC6 A;  8PCH A;  4BS6 A;  4NV7 A;  1JQP A;  2NQA A;  2E02 A;  3OF9 A;  5CHV A;  4CDF B;  1VJV A;  5EGW A;  4YVA A;  4RY2 A;  4QBB A;  2OUL A;  1GCB A;  3MOR A;  4X6J A;  4BQV A;  4YYU A;  2FRA A;  1PPD A;  4DMY A;  2NQG A;  4P6G A;  2HD5 A;  4QRV A;  2ATO A;  9PAP A;  2DC7 A;  1PPO A;  1Y4H A;  3KWB X;  3QSD A;  5JA7 A;  1W5R A;  2JQF R;  1DF0 A;  3QT4 A;  1S4V A;  1CVZ A;  2OZ2 A;  4QRG A;  1IWD A;  3BC3 A;  1YVB A;  3CBJ A;  1MEG A;  3CBK A;  2VFB A;  3IMA A;  3C9E A;  1YAL A;  3F5V A;  3NHE A;  2AVW A;  4YYV A;  2BDZ A;  3IV2 A;  1BQI A;  4B55 A;  2AUX A;  3IUT A;  2PRE A;  2YJC A;  3E1Z B;  2DC8 A;  4K7C A;  4PAD A;  2DC9 A;  4X6H A;  4N8W A;  4W5C A;  3S3R A;  1F2B A;  4N4Z A;  1F2C A;  2GFO A;  2IBI A;  1PAD A;  3P5X A;  3WXG A;  1F2A A;  4FIP A;  2G8J A;  1O0E A;  1AIM A;  3D9W A;  1CV8 A;  3CH2 X;  2XU5 A;  3HWN A;  5K16 A;  3PBH A;  4DMX A;  1NLJ A;  1CTE A;  3K24 A;  3WXE A;  1QOL A;  3AI8 A;  1AU2 A;  2PAD A;  1W6F A;  3KW9 A;  3OVZ A;  2CB5 A;  1GLO A;  4AXL A;  2OP3 A;  1BY8 A;  1KXR A;  2R6N A;  4BSQ A;  2C0Y A;  1M6D A;  2R9N A;  2FYE A;  3TNX A;  4CDC B;  2DCB A;  1ITO A;  2P0R A;  2AU1 A;  4PI3 A;  3PNR A;  3B79 A;  3KX1 A;  2PNS A;  1VSN A;  2IPP B;  4YYW A;  3O0U A;  4OEL A;  3S3Q A;  4BPV A;  1KFX L;  3PDF A;  7PCK A;  3LFY A;  1HUC B;  1NQC A;  4QH6 A;  1AYW A;  1SNK A;  1NB5 A;  1U9Q X;  1DEU A;  3M99 A;  1YK8 A;  5CVN B;  4G54 A;  3HHI A;  2PBH A;  2P86 A;  3BWK A;  2ARY A;  5JH3 A;  2E01 A;  2AYN A;  3CH3 X;  3KSE A;  2G6D A;  2F7D A;  6PAD A;  3ERV A;  1POP A;  4Q8G A;  1AU0 A;  2DZZ A;  1GEC E;  2XU1 A;  2AIM A;  1PPN A;  2Y5B A;  2HXZ A;  1XKG A;  4X6I A;  1NL6 A;  4FK5 A;  1CS8 A;  2AUZ A;  4AXM A;  4YYQ A;  1MIR A;  5EF4 A;  4MSX A;  5J94 A;  1YK7 A;  4I05 A;  2HH5 A;  1BGO A;  3IEJ A;  3N3G A;  3HD3 A;  3I3T A;  3DF0 A;  3IHP A;  3KKU A;  3OF8 A;  1Q6K A;  5A24 A;  3H7D A;  1E2T A;  3QJ3 A;  3K8U A;  2F1G A;  3MHH A;  4P6E A;  3RVX A;  2GHU A;  3PW3 A;  1TU6 A;  3RVW A;  1F29 A;  4MZO A;  2B1M A;  3V6C A;  1U9X A;  2P7U A;  4I07 A;  1KFU L;  1TLO A;  4MZS A;  1CJL A;  2VHF A;  2DJF B;  3BCN A;  1U9V A;  3LXS A;  2DJG B;  1PIP A;  4ZUX U;  1X9Y A;  1BP4 A;  2Y6E A;  4W5B A;  1PCI A;  4WA6 A;  1FH0 A;  1CQD A;  1PXV A;  1U5I A;  4FJC A;  4BGF A;  2FUD A;  2O6X A;  2R9F A;  1PPP A;  1YT7 A;  2VHS A;  2AYO A;  1STF E;  4C5P A;  3RVV A;  3KWZ A;  2DCA A;  3H8B A;  2R9O A;  1ZIV A;  5FPW A;  4NV8 A;  3MHS A;  1MS6 A;  4PP2 E;  3P5W A;  5CHT A;  2FO5 A;  2FT2 A;  1KHQ A;  1MEM A;  4YV8 A;  1AU3 A;  3BPF A;  2CIO A;  1Y08 A;  1ZCM A;  3P5V A;  2E03 A;  1AU4 A;  2FRQ A;  1PBH A;  4N79 A;  2G8E A;  3V6E A;  3OVX A;  1AEC A;  3P5U A;  4PP1 A;  1GX3 A;  2ACT A;  1A6R A;  2YJB A;  1ICF A;  4YYS A;  3USV A;  2NQI A;  3ZUA A;  1QMY A;  2AS8 A;  3F75 A;  2H7J A;  1GMY A;  1U9W A;  3H89 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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