1ME4A

High resolution crystal structure analysis of cruzain non-covalently bound to a hydroxymethyl ketone inhibitor (i)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma cruzi
molecule keywords CRUZIPAIN
total genus 62
structure length 215
sequence length 215
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2002-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1me4A00
1F2CA 4KLBA 3WXFA 4PADA 1CV8A 2ACTA 4W4UA 2XU4A 3P5XA 1ICFA 3N4CA 3OF8A 1PPDA 4YYVA 1O0EA 5FPWA 2Y6EA 2WBFX 1PBHA 1DF0A 1GECE 4MZSA 3PDFA 1EWPA 3LFYA 3F5VA 1PE6A 1SNKA 2HXZA 2DJGB 3I06A 1THEA 3PW3A 2PREA 3QJ3A 1NQCA 1STFE 4XUIA 3RVWA 2HHNA 4I05A 2IPPB 4BPVA 5CHTA 1VSNA 3V6CA 1TLOA 1CVZA 3KWBX 4CZWA 1AU2A 2Y5BA 3OVXA 1PCIA 1DEUA 4QH6A 1YALA 4BS5A 3TNXA 8PCHA 3MHSA 5CVNB 4QRGA 3IV2A 2FUDA 1AYUA 2B1NA 1CJLA 1CB5A 1QDQA 2AYOA 4OELA 2FT2A 2VHFA 4HWYA 1ATKA 2OULA 3CH2X 1EWOA 1ZIVA 1PPNA 1AU4A 4YYQA 3BCNA 2DJFB 2HH5A 2F7DA 1NB5A 1NLJA 2IBIA 3O0UA 3BOWA 1BP4A 1JQPA 3OVZA 4BQVA 2GFOA 4W5CA 3AI8A 1KHPA 3M99A 3KKUA 1YVBA 5K16A 2AVWA 4QBBA 2DZZA 3F75A 2R9MA 3ZUAA 4YVAA 4YYWA 1AU3A 1KFUL 4W5BA 2E00A 2DC7A 2YJ2A 2P0RA 3IUTA 1S4VA 2DC6A 2H7JA 3KWZA 5CHVA 1ZCMA 2DCAA 1Q6KA 1HUCB 5PADA 2G6DA 1CQDA 2R6NA 3D6SA 4YV8A 2G7YA 4YYRA 3RVVA 4QRVA 2ARYA 1U9QX 2R9CA 2YJBA 2YJ8A 4Q8HA 3I3TA 4PP1A 1ITOA 2JQFR 2BDZA 1NPZA 1POPA 5JH3A 1EWMA 6PADA 2ATOA 1PIPA 3IHPA 2XU3A 4I07A 1GMYA 1F2BA 3P5VA 2R9FA 3MHHA 2P7UA 1MS6A 3OISA 4Q8GA 3PBHA 4G54A 1BY8A 3PNRA 3BPMA 4RY2A 7PCKA 1YT7A 1QOLA 2HD5A 1A6RA 5EF4A 1U5IA 3H8CA 1U9VA 1Y4HA 1AECA 3GCBA 4X6JA 1IWDA 1QXPA 4DMXA 4P6GA 3IOQA 2CB5A 3P5UA 1X9YA 1NL6A 4OEMA 1U9WA 2FO5A 3WXEA 1CSBB 2FRQA 4FJCA 2DC8A 3KW9A 3MORA 2AYNA 2AU1A 3S3QA 1ME4A 4N8WA 1EF7A 3N3KA 3K9MA 1AYWA 2YJ9A 3KFQA 2GHUA 2FYEA 2P86A 3BWKA 1BQIA 3QT4A 2OP3A 3HHAA 2XU1A 2AIMA 4P6EA 4XR7A 2NQGA 2OZ2A 4K7CA 4ZUXU 2CIOA 1PPPA 5CVOB 1K3BB 1KXRA 3H8BA 1TL9A 4AXMA 3V6EA 3HWNA 2F1GA 2DCDA 3NHEA 3B79A 4DMYA 1VJVA 2NQIA 3CBJA 2PBHA 4YYUA 1PPOA 5A24A 1AU0A 2C0YA 2PNSA 2E02A 2NQDB 2R9OA 4FK5A 2FRAA 4CDEB 2DC9A 3KX1A 1YK7A 3P5WA 4QRXA 1Y08A 2BDLA 2XU5A 4PI3A 4YYSA 1QMYA 1MHWA 2JQGR 3S3RA 3H6SA 3E1ZB 4N4ZA 4I04A 1KHQA 4CDCB 2AUZA 2E03A 2PADA 3K24A 1MEGA 2AS8A 3CBKA 2DZYA 2AUXA 3ERVA 3HD3A 4FIPA 2DCBA 3MTNA 3KSEA 3LXSA 3C9EA 3BPFA 2B1MA 2VHSA 1F2AA 3K8UA 4PP2E 4CDFB 2FQ9A 1BGOA 1NB3A 4WA6A 9PAPA 1CTEA 4AXLA 1ME3A 4CDDB 3QSDA 1MIRA 1EWLA 3USVA 2FTDA 4BS6A 2YJCA 3U8EA 3HHIA 1F29A 1TU6A 3O1GA 4MZOA 1PXVA 3H7DA 2G8EA 3WXGA 3CH3X 2O6XA 4BSQA 1AYVA 5CVMA 1M6DA 3H89A 1U9XA 1GLOA 1PADA 2DCCA 4X6HA 3OF9A 1XKGA 3N3GA 3IEJA 1YK8A 1CPJA 3DF0A 1CS8A 2E01A 1KFXL 2R9NA 5JA7A 1MDWA 4X6IA 1SP4B 1MEMA 1FH0A 5J94A 3BC3A 2G8JA 2NQAA 5F02A 4N79A 1AIMA 4MSXA 5EGWA 1GCBA 3IMAA 3RVXA
chains in the Genus database with same CATH superfamily
1F2CA 4OW0A 4KLBA 3WXFA 4PADA 1CV8A 4IP3A 2ACTA 4W4UA 2XU4A 3P5XA 1ICFA 3N4CA 3OF8A 3MJ5A 1PPDA 4YYVA 1O0EA 5FPWA 2Y6EA 2WBFX 1PBHA 1DF0A 1GECE 4MZSA 3PDFA 1EWPA 1DKIA 3LFYA 3F5VA 1PE6A 1SNKA 2HXZA 2DJGB 3I06A 1THEA 3PW3A 4RNAA 3MTVA 2PREA 3QJ3A 1NQCA 1STFE 4XUIA 3RVWA 2HHNA 3PHXA 4I05A 2IPPB 4BPVA 5CHTA 1VSNA 3V6CA 1TLOA 1CVZA 4RKXA 3KWBX 4CZWA 1AU2A 2Y5BA 3OVXA 1PCIA 1DEUA 4QH6A 1YALA 4BS5A 3TNXA 8PCHA 3MHSA 2FE8A 5CVNB 4QRGA 3IV2A 2FUDA 1AYUA 2B1NA 1CJLA 1CB5A 1QDQA 2AYOA 4D8BA 4OELA 4OVZA 2FT2A 2VHFA 2UZJA 4HWYA 1ATKA 2OULA 3CH2X 1EWOA 1ZIVA 1PPNA 1AU4A 4YYQA 3BCNA 2DJFB 2HH5A 2F7DA 1NB5A 1NLJA 2IBIA 3O0UA 3BOWA 4R3DA 1BP4A 1JQPA 3OVZA 4BQVA 2JTCA 2GFOA 4W5CA 3AI8A 4XZXA 1KHPA 3M99A 3KKUA 1YVBA 5K16A 2AVWA 4QBBA 2DZZA 3F75A 4RF0A 4D8IA 2R9MA 3ZUAA 4YVAA 4YYWA 1AU3A 4BOSA 1KFUL 4W5BA 4IUMA 3W30A 2E00A 2DC7A 5EZSA 2YJ2A 2BU3A 2P0RA 3IUTA 1S4VA 2DC6A 2H7JA 3KWZA 5CHVA 1ZCMA 5E6JA 4D8EA 2DCAA 3PRPA 1Q6KA 1HUCB 5PADA 2G6DA 5EZQA 1CQDA 2R6NA 3D6SA 4YV8A 2G7YA 4YYRA 4BOUA 3RVVA 4QRVA 2ARYA 1U9QX 2R9CA 1UKFA 2YJBA 2YJ8A 4Q8HA 3I3TA 4PP1A 5JZEA 1ITOA 2JQFR 2BDZA 1NPZA 1POPA 5JH3A 1EWMA 6PADA 2ATOA 4PT5A 1PIPA 2JRIA 2XU3A 3IHPA 4I07A 1GMYA 2BTWA 1F2BA 3P5VA 2R9FA 3MHHA 3PSEA 2P7UA 4RF1A 1MS6A 3OISA 4Q8GA 3PBHA 4P16A 4G54A 1BY8A 3PNRA 3BPMA 4RY2A 7PCKA 1YT7A 1QOLA 2HD5A 3PHUA 1A6RA 4M0WA 5EF4A 1U5IA 3O65A 3H8CA 1U9VA 1Y4HA 1AECA 3GCBA 4X6JA 1IWDA 1QXPA 4DMXA 4P6GA 3TRKA 3IOQA 2CB5A 3P5UA 1X9YA 1NL6A 4OEMA 1U9WA 2FO5A 3WXEA 1CSBB 2FRQA 4FJCA 2DC8A 3KW9A 3MORA 2AYNA 2AU1A 3S3QA 4ZTBA 1ME4A 4N8WA 3B21A 5KO3A 1EF7A 3N3KA 3K9MA 1YZBA 1AYWA 2YJ9A 3KFQA 2GHUA 2FYEA 2P86A 3BWKA 1BQIA 3QT4A 2OP3A 3OQCA 3HHAA 2XU1A 2AIMA 4P6EA 4XR7A 2NQGA 2OZ2A 4K7CA 4GUAA 4ZUXU 2CIOA 1PPPA 5CVOB 1K3BB 1KXRA 4BOZA 3H8BA 1TL9A 4AXMA 3V6EA 3HWNA 2F1GA 2DCDA 3NHEA 3IFUA 3E9SA 3B79A 3MP2A 4DMYA 1VJVA 2NQIA 3CBJA 3BBAA 2PBHA 4YYUA 2DOSA 4OVZB 1PPOA 5A24A 1AU0A 3BY4A 2C0YA 2PNSA 2E02A 2NQDB 2R9OA 4FK5A 2FRAA 4CDEB 2DC9A 3KX1A 1YK7A 3P5WA 4QRXA 1Y08A 3TMPA 2BDLA 2XU5A 4PI3A 4YYSA 1QMYA 1MHWA 2JQGR 3S3RA 3H6SA 3E1ZB 4N4ZA 4I04A 1KHQA 4CDCB 2AUZA 2E03A 2PADA 3K24A 1MEGA 2AS8A 3CBKA 2DZYA 2AGAA 2AUXA 3PHWA 3ERVA 3W31A 3HD3A 4FIPA 3PT2A 4HXDB 2DCBA 3MTNA 3KSEA 3LXSA 3C9EA 3BPFA 2B1MA 2VHSA 1F2AA 3K8UA 4PP2E 4CDFB 2FQ9A 4A5UA 1BGOA 3BB7A 1NB3A 4WA6A 9PAPA 1CTEA 4AXLA 1ME3A 4CDDB 3QSDA 1MIRA 2J7QA 1EWLA 3USVA 2FTDA 4BS6A 2YJCA 3U8EA 3HHIA 1F29A 1TU6A 4BOPA 3O1GA 4MZOA 1PXVA 4REZA 4BOQA 3H7DA 2G8EA 3WXGA 3CH3X 2O6XA 4MI7A 4BSQA 1AYVA 5CVMA 1M6DA 3PRMA 3H89A 1U9XA 1GLOA 1PADA 2BTWB 1PVJA 4WURA 2DCCA 4X6HA 2Z84A 3OF9A 1XKGA 3N3GA 3IEJA 1YK8A 1CPJA 3DF0A 1CS8A 2E01A 1KFXL 2R9NA 5JA7A 1MDWA 4X6IA 1SP4B 1MEMA 1FH0A 2J7QC 3C0RA 2HWKA 5J94A 3BC3A 2G8JA 2NQAA 5F02A 4N79A 1AIMA 3ZNHA 4MSXA 5EGWA 1GCBA 3IMAA 3RVXA 4MM3B 3RNVA
chains in the Genus database with same CATH topology
1F2CA 4KLBA 3WXFA 4PADA 1CV8A 2ACTA 4W4UA 2XU4A 3P5XA 1ICFA 3N4CA 3OF8A 1PPDA 4YYVA 1O0EA 5FPWA 2Y6EA 2WBFX 1PBHA 1DF0A 1GECE 4MZSA 3PDFA 1EWPA 3LFYA 3F5VA 2VFCA 1PE6A 1SNKA 2HXZA 2DJGB 3I06A 1THEA 3PW3A 1GX3A 2PREA 3QJ3A 1NQCA 1STFE 4XUIA 3RVWA 2HHNA 4I05A 2IPPB 4BPVA 5CHTA 1VSNA 3V6CA 1TLOA 1CVZA 3KWBX 4CZWA 1AU2A 2Y5BA 3OVXA 1PCIA 1DEUA 4QH6A 1YALA 4BS5A 3TNXA 8PCHA 3MHSA 5CVNB 4QRGA 3IV2A 2FUDA 1AYUA 2B1NA 1CJLA 1CB5A 1QDQA 2AYOA 4OELA 2FT2A 2VHFA 4HWYA 2VFBA 1ATKA 2OULA 3CH2X 1EWOA 1ZIVA 1PPNA 1AU4A 4YYQA 3BCNA 2DJFB 2HH5A 2F7DA 1NB5A 1NLJA 2IBIA 3O0UA 3BOWA 1BP4A 1JQPA 3OVZA 4BQVA 2GFOA 4W5CA 3AI8A 1KHPA 3M99A 3KKUA 1YVBA 5K16A 2AVWA 4QBBA 2DZZA 3F75A 2R9MA 3ZUAA 4YVAA 4YYWA 1AU3A 1KFUL 4W5BA 2E00A 2DC7A 2YJ2A 2P0RA 3IUTA 1S4VA 2DC6A 2H7JA 3KWZA 5CHVA 1ZCMA 4GUZA 2DCAA 1Q6KA 1HUCB 5PADA 2G6DA 1CQDA 2R6NA 3D6SA 4YV8A 4BGFA 2G7YA 4YYRA 3RVVA 4QRVA 2ARYA 1U9QX 2R9CA 2YJBA 4B55A 2YJ8A 4Q8HA 3I3TA 4PP1A 1ITOA 2JQFR 2BDZA 1NPZA 1POPA 5JH3A 1EWMA 6PADA 2ATOA 1PIPA 3IHPA 2XU3A 4I07A 1GMYA 1F2BA 1W4TA 3P5VA 2R9FA 3MHHA 4C5PA 2P7UA 1MS6A 3OISA 4Q8GA 3PBHA 4G54A 1BY8A 3PNRA 3BPMA 4RY2A 7PCKA 1YT7A 1QOLA 2HD5A 1A6RA 5EF4A 1U5IA 3H8CA 1U9VA 1Y4HA 1AECA 3GCBA 4X6JA 1IWDA 1QXPA 4DMXA 4P6GA 3IOQA 2CB5A 3P5UA 1X9YA 1NL6A 4OEMA 1U9WA 2FO5A 3WXEA 1CSBB 2FRQA 4FJCA 2DC8A 3KW9A 3MORA 2AYNA 2AU1A 3S3QA 1ME4A 4N8WA 1EF7A 3N3KA 2BSZA 3K9MA 1AYWA 2YJ9A 3KFQA 2GHUA 2FYEA 2P86A 3BWKA 1BQIA 3QT4A 2OP3A 3HHAA 2XU1A 2AIMA 4P6EA 4XR7A 2NQGA 2OZ2A 4K7CA 4ZUXU 2CIOA 1PPPA 5CVOB 1K3BB 1KXRA 4NV7A 3H8BA 1TL9A 4AXMA 3V6EA 3HWNA 2F1GA 2DCDA 3NHEA 3B79A 3D9WA 4DMYA 1VJVA 2NQIA 3CBJA 2PBHA 4YYUA 1PPOA 5A24A 1AU0A 2C0YA 2PNSA 2E02A 2NQDB 2R9OA 4FK5A 2FRAA 4CDEB 2DC9A 3KX1A 1YK7A 1W5RA 3P5WA 4QRXA 1Y08A 2BDLA 2XU5A 4PI3A 4YYSA 1QMYA 1MHWA 2JQGR 3S3RA 3H6SA 3E1ZB 4N4ZA 4I04A 1KHQA 4CDCB 2AUZA 2E03A 2PADA 3K24A 1MEGA 2AS8A 3CBKA 2DZYA 2AUXA 3ERVA 3HD3A 4FIPA 2DCBA 3MTNA 3KSEA 3LXSA 3C9EA 3BPFA 2B1MA 2VHSA 1F2AA 3K8UA 4PP2E 4CDFB 2FQ9A 1BGOA 1NB3A 4WA6A 9PAPA 1CTEA 4AXLA 1ME3A 4CDDB 3QSDA 1MIRA 1EWLA 3USVA 2FTDA 4BS6A 2YJCA 3U8EA 3HHIA 1F29A 1TU6A 3O1GA 4MZOA 1PXVA 3H7DA 2G8EA 3WXGA 3CH3X 2O6XA 4BSQA 1AYVA 5CVMA 1M6DA 3H89A 1U9XA 1GLOA 1PADA 2DCCA 4X6HA 3OF9A 1XKGA 3N3GA 3IEJA 1YK8A 1CPJA 1W6FA 3DF0A 1CS8A 2E01A 1KFXL 2R9NA 1E2TA 5JA7A 1MDWA 4X6IA 1SP4B 1MEMA 4NV8A 1FH0A 3LTWA 5J94A 3BC3A 2G8JA 2NQAA 5F02A 4N79A 1AIMA 4MSXA 5EGWA 1GCBA 3IMAA 3RVXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F2C A;  4KLB A;  3WXF A;  4PAD A;  1CV8 A;  2ACT A;  4W4U A;  2XU4 A;  3P5X A;  1ICF A;  3N4C A;  3OF8 A;  1PPD A;  4YYV A;  1O0E A;  5FPW A;  2Y6E A;  2WBF X;  1PBH A;  1DF0 A;  1GEC E;  4MZS A;  3PDF A;  1EWP A;  3LFY A;  3F5V A;  1PE6 A;  1SNK A;  2HXZ A;  2DJG B;  3I06 A;  1THE A;  3PW3 A;  2PRE A;  3QJ3 A;  1NQC A;  1STF E;  4XUI A;  3RVW A;  2HHN A;  4I05 A;  2IPP B;  4BPV A;  5CHT A;  1VSN A;  3V6C A;  1TLO A;  1CVZ A;  3KWB X;  4CZW A;  1AU2 A;  2Y5B A;  3OVX A;  1PCI A;  1DEU A;  4QH6 A;  1YAL A;  4BS5 A;  3TNX A;  8PCH A;  3MHS A;  5CVN B;  4QRG A;  3IV2 A;  2FUD A;  1AYU A;  2B1N A;  1CJL A;  1CB5 A;  1QDQ A;  2AYO A;  4OEL A;  2FT2 A;  2VHF A;  4HWY A;  1ATK A;  2OUL A;  3CH2 X;  1EWO A;  1ZIV A;  1PPN A;  1AU4 A;  4YYQ A;  3BCN A;  2DJF B;  2HH5 A;  2F7D A;  1NB5 A;  1NLJ A;  2IBI A;  3O0U A;  3BOW A;  1BP4 A;  1JQP A;  3OVZ A;  4BQV A;  2GFO A;  4W5C A;  3AI8 A;  1KHP A;  3M99 A;  3KKU A;  1YVB A;  5K16 A;  2AVW A;  4QBB A;  2DZZ A;  3F75 A;  2R9M A;  3ZUA A;  4YVA A;  4YYW A;  1AU3 A;  1KFU L;  4W5B A;  2E00 A;  2DC7 A;  2YJ2 A;  2P0R A;  3IUT A;  1S4V A;  2DC6 A;  2H7J A;  3KWZ A;  5CHV A;  1ZCM A;  2DCA A;  1Q6K A;  1HUC B;  5PAD A;  2G6D A;  1CQD A;  2R6N A;  3D6S A;  4YV8 A;  2G7Y A;  4YYR A;  3RVV A;  4QRV A;  2ARY A;  1U9Q X;  2R9C A;  2YJB A;  2YJ8 A;  4Q8H A;  3I3T A;  4PP1 A;  1ITO A;  2JQF R;  2BDZ A;  1NPZ A;  1POP A;  5JH3 A;  1EWM A;  6PAD A;  2ATO A;  1PIP A;  3IHP A;  2XU3 A;  4I07 A;  1GMY A;  1F2B A;  3P5V A;  2R9F A;  3MHH A;  2P7U A;  1MS6 A;  3OIS A;  4Q8G A;  3PBH A;  4G54 A;  1BY8 A;  3PNR A;  3BPM A;  4RY2 A;  7PCK A;  1YT7 A;  1QOL A;  2HD5 A;  1A6R A;  5EF4 A;  1U5I A;  3H8C A;  1U9V A;  1Y4H A;  1AEC A;  3GCB A;  4X6J A;  1IWD A;  1QXP A;  4DMX A;  4P6G A;  3IOQ A;  2CB5 A;  3P5U A;  1X9Y A;  1NL6 A;  4OEM A;  1U9W A;  2FO5 A;  3WXE A;  1CSB B;  2FRQ A;  4FJC A;  2DC8 A;  3KW9 A;  3MOR A;  2AYN A;  2AU1 A;  3S3Q A;  1ME4 A;  4N8W A;  1EF7 A;  3N3K A;  3K9M A;  1AYW A;  2YJ9 A;  3KFQ A;  2GHU A;  2FYE A;  2P86 A;  3BWK A;  1BQI A;  3QT4 A;  2OP3 A;  3HHA A;  2XU1 A;  2AIM A;  4P6E A;  4XR7 A;  2NQG A;  2OZ2 A;  4K7C A;  4ZUX U;  2CIO A;  1PPP A;  5CVO B;  1K3B B;  1KXR A;  3H8B A;  1TL9 A;  4AXM A;  3V6E A;  3HWN A;  2F1G A;  2DCD A;  3NHE A;  3B79 A;  4DMY A;  1VJV A;  2NQI A;  3CBJ A;  2PBH A;  4YYU A;  1PPO A;  5A24 A;  1AU0 A;  2C0Y A;  2PNS A;  2E02 A;  2NQD B;  2R9O A;  4FK5 A;  2FRA A;  4CDE B;  2DC9 A;  3KX1 A;  1YK7 A;  3P5W A;  4QRX A;  1Y08 A;  2BDL A;  2XU5 A;  4PI3 A;  4YYS A;  1QMY A;  1MHW A;  2JQG R;  3S3R A;  3H6S A;  3E1Z B;  4N4Z A;  4I04 A;  1KHQ A;  4CDC B;  2AUZ A;  2E03 A;  2PAD A;  3K24 A;  1MEG A;  2AS8 A;  3CBK A;  2DZY A;  2AUX A;  3ERV A;  3HD3 A;  4FIP A;  2DCB A;  3MTN A;  3KSE A;  3LXS A;  3C9E A;  3BPF A;  2B1M A;  2VHS A;  1F2A A;  3K8U A;  4PP2 E;  4CDF B;  2FQ9 A;  1BGO A;  1NB3 A;  4WA6 A;  9PAP A;  1CTE A;  4AXL A;  1ME3 A;  4CDD B;  3QSD A;  1MIR A;  1EWL A;  3USV A;  2FTD A;  4BS6 A;  2YJC A;  3U8E A;  3HHI A;  1F29 A;  1TU6 A;  3O1G A;  4MZO A;  1PXV A;  3H7D A;  2G8E A;  3WXG A;  3CH3 X;  2O6X A;  4BSQ A;  1AYV A;  5CVM A;  1M6D A;  3H89 A;  1U9X A;  1GLO A;  1PAD A;  2DCC A;  4X6H A;  3OF9 A;  1XKG A;  3N3G A;  3IEJ A;  1YK8 A;  1CPJ A;  3DF0 A;  1CS8 A;  2E01 A;  1KFX L;  2R9N A;  5JA7 A;  1MDW A;  4X6I A;  1SP4 B;  1MEM A;  1FH0 A;  5J94 A;  3BC3 A;  2G8J A;  2NQA A;  5F02 A;  4N79 A;  1AIM A;  4MSX A;  5EGW A;  1GCB A;  3IMA A;  3RVX A; 
#chains in the Genus database with same CATH topology
 1F2C A;  4OW0 A;  4KLB A;  3WXF A;  4PAD A;  1CV8 A;  4IP3 A;  2ACT A;  4W4U A;  2XU4 A;  3P5X A;  1ICF A;  3N4C A;  3OF8 A;  3MJ5 A;  1PPD A;  4YYV A;  1O0E A;  5FPW A;  2Y6E A;  2WBF X;  1PBH A;  1DF0 A;  1GEC E;  4MZS A;  3PDF A;  1EWP A;  1DKI A;  3LFY A;  3F5V A;  1PE6 A;  1SNK A;  2HXZ A;  2DJG B;  3I06 A;  1THE A;  3PW3 A;  4RNA A;  3MTV A;  2PRE A;  3QJ3 A;  1NQC A;  1STF E;  4XUI A;  3RVW A;  2HHN A;  3PHX A;  4I05 A;  2IPP B;  4BPV A;  5CHT A;  1VSN A;  3V6C A;  1TLO A;  1CVZ A;  4RKX A;  3KWB X;  4CZW A;  1AU2 A;  2Y5B A;  3OVX A;  1PCI A;  1DEU A;  4QH6 A;  1YAL A;  4BS5 A;  3TNX A;  8PCH A;  3MHS A;  2FE8 A;  5CVN B;  4QRG A;  3IV2 A;  2FUD A;  1AYU A;  2B1N A;  1CJL A;  1CB5 A;  1QDQ A;  2AYO A;  4D8B A;  4OEL A;  4OVZ A;  2FT2 A;  2VHF A;  2UZJ A;  4HWY A;  1ATK A;  2OUL A;  3CH2 X;  1EWO A;  1ZIV A;  1PPN A;  1AU4 A;  4YYQ A;  3BCN A;  2DJF B;  2HH5 A;  2F7D A;  1NB5 A;  1NLJ A;  2IBI A;  3O0U A;  3BOW A;  4R3D A;  1BP4 A;  1JQP A;  3OVZ A;  4BQV A;  2JTC A;  2GFO A;  4W5C A;  3AI8 A;  4XZX A;  1KHP A;  3M99 A;  3KKU A;  1YVB A;  5K16 A;  2AVW A;  4QBB A;  2DZZ A;  3F75 A;  4RF0 A;  4D8I A;  2R9M A;  3ZUA A;  4YVA A;  4YYW A;  1AU3 A;  4BOS A;  1KFU L;  4W5B A;  4IUM A;  3W30 A;  2E00 A;  2DC7 A;  5EZS A;  2YJ2 A;  2BU3 A;  2P0R A;  3IUT A;  1S4V A;  2DC6 A;  2H7J A;  3KWZ A;  5CHV A;  1ZCM A;  5E6J A;  4D8E A;  2DCA A;  3PRP A;  1Q6K A;  1HUC B;  5PAD A;  2G6D A;  5EZQ A;  1CQD A;  2R6N A;  3D6S A;  4YV8 A;  2G7Y A;  4YYR A;  4BOU A;  3RVV A;  4QRV A;  2ARY A;  1U9Q X;  2R9C A;  1UKF A;  2YJB A;  2YJ8 A;  4Q8H A;  3I3T A;  4PP1 A;  5JZE A;  1ITO A;  2JQF R;  2BDZ A;  1NPZ A;  1POP A;  5JH3 A;  1EWM A;  6PAD A;  2ATO A;  4PT5 A;  1PIP A;  2JRI A;  2XU3 A;  3IHP A;  4I07 A;  1GMY A;  2BTW A;  1F2B A;  3P5V A;  2R9F A;  3MHH A;  3PSE A;  2P7U A;  4RF1 A;  1MS6 A;  3OIS A;  4Q8G A;  3PBH A;  4P16 A;  4G54 A;  1BY8 A;  3PNR A;  3BPM A;  4RY2 A;  7PCK A;  1YT7 A;  1QOL A;  2HD5 A;  3PHU A;  1A6R A;  4M0W A;  5EF4 A;  1U5I A;  3O65 A;  3H8C A;  1U9V A;  1Y4H A;  1AEC A;  3GCB A;  4X6J A;  1IWD A;  1QXP A;  4DMX A;  4P6G A;  3TRK A;  3IOQ A;  2CB5 A;  3P5U A;  1X9Y A;  1NL6 A;  4OEM A;  1U9W A;  2FO5 A;  3WXE A;  1CSB B;  2FRQ A;  4FJC A;  2DC8 A;  3KW9 A;  3MOR A;  2AYN A;  2AU1 A;  3S3Q A;  4ZTB A;  1ME4 A;  4N8W A;  3B21 A;  5KO3 A;  1EF7 A;  3N3K A;  3K9M A;  1YZB A;  1AYW A;  2YJ9 A;  3KFQ A;  2GHU A;  2FYE A;  2P86 A;  3BWK A;  1BQI A;  3QT4 A;  2OP3 A;  3OQC A;  3HHA A;  2XU1 A;  2AIM A;  4P6E A;  4XR7 A;  2NQG A;  2OZ2 A;  4K7C A;  4GUA A;  4ZUX U;  2CIO A;  1PPP A;  5CVO B;  1K3B B;  1KXR A;  4BOZ A;  3H8B A;  1TL9 A;  4AXM A;  3V6E A;  3HWN A;  2F1G A;  2DCD A;  3NHE A;  3IFU A;  3E9S A;  3B79 A;  3MP2 A;  4DMY A;  1VJV A;  2NQI A;  3CBJ A;  3BBA A;  2PBH A;  4YYU A;  2DOS A;  4OVZ B;  1PPO A;  5A24 A;  1AU0 A;  3BY4 A;  2C0Y A;  2PNS A;  2E02 A;  2NQD B;  2R9O A;  4FK5 A;  2FRA A;  4CDE B;  2DC9 A;  3KX1 A;  1YK7 A;  3P5W A;  4QRX A;  1Y08 A;  3TMP A;  2BDL A;  2XU5 A;  4PI3 A;  4YYS A;  1QMY A;  1MHW A;  2JQG R;  3S3R A;  3H6S A;  3E1Z B;  4N4Z A;  4I04 A;  1KHQ A;  4CDC B;  2AUZ A;  2E03 A;  2PAD A;  3K24 A;  1MEG A;  2AS8 A;  3CBK A;  2DZY A;  2AGA A;  2AUX A;  3PHW A;  3ERV A;  3W31 A;  3HD3 A;  4FIP A;  3PT2 A;  4HXD B;  2DCB A;  3MTN A;  3KSE A;  3LXS A;  3C9E A;  3BPF A;  2B1M A;  2VHS A;  1F2A A;  3K8U A;  4PP2 E;  4CDF B;  2FQ9 A;  4A5U A;  1BGO A;  3BB7 A;  1NB3 A;  4WA6 A;  9PAP A;  1CTE A;  4AXL A;  1ME3 A;  4CDD B;  3QSD A;  1MIR A;  2J7Q A;  1EWL A;  3USV A;  2FTD A;  4BS6 A;  2YJC A;  3U8E A;  3HHI A;  1F29 A;  1TU6 A;  4BOP A;  3O1G A;  4MZO A;  1PXV A;  4REZ A;  4BOQ A;  3H7D A;  2G8E A;  3WXG A;  3CH3 X;  2O6X A;  4MI7 A;  4BSQ A;  1AYV A;  5CVM A;  1M6D A;  3PRM A;  3H89 A;  1U9X A;  1GLO A;  1PAD A;  2BTW B;  1PVJ A;  4WUR A;  2DCC A;  4X6H A;  2Z84 A;  3OF9 A;  1XKG A;  3N3G A;  3IEJ A;  1YK8 A;  1CPJ A;  3DF0 A;  1CS8 A;  2E01 A;  1KFX L;  2R9N A;  5JA7 A;  1MDW A;  4X6I A;  1SP4 B;  1MEM A;  1FH0 A;  2J7Q C;  3C0R A;  2HWK A;  5J94 A;  3BC3 A;  2G8J A;  2NQA A;  5F02 A;  4N79 A;  1AIM A;  3ZNH A;  4MSX A;  5EGW A;  1GCB A;  3IMA A;  3RVX A;  4MM3 B;  3RNV A; 
#chains in the Genus database with same CATH homology
 1F2C A;  4KLB A;  3WXF A;  4PAD A;  1CV8 A;  2ACT A;  4W4U A;  2XU4 A;  3P5X A;  1ICF A;  3N4C A;  3OF8 A;  1PPD A;  4YYV A;  1O0E A;  5FPW A;  2Y6E A;  2WBF X;  1PBH A;  1DF0 A;  1GEC E;  4MZS A;  3PDF A;  1EWP A;  3LFY A;  3F5V A;  2VFC A;  1PE6 A;  1SNK A;  2HXZ A;  2DJG B;  3I06 A;  1THE A;  3PW3 A;  1GX3 A;  2PRE A;  3QJ3 A;  1NQC A;  1STF E;  4XUI A;  3RVW A;  2HHN A;  4I05 A;  2IPP B;  4BPV A;  5CHT A;  1VSN A;  3V6C A;  1TLO A;  1CVZ A;  3KWB X;  4CZW A;  1AU2 A;  2Y5B A;  3OVX A;  1PCI A;  1DEU A;  4QH6 A;  1YAL A;  4BS5 A;  3TNX A;  8PCH A;  3MHS A;  5CVN B;  4QRG A;  3IV2 A;  2FUD A;  1AYU A;  2B1N A;  1CJL A;  1CB5 A;  1QDQ A;  2AYO A;  4OEL A;  2FT2 A;  2VHF A;  4HWY A;  2VFB A;  1ATK A;  2OUL A;  3CH2 X;  1EWO A;  1ZIV A;  1PPN A;  1AU4 A;  4YYQ A;  3BCN A;  2DJF B;  2HH5 A;  2F7D A;  1NB5 A;  1NLJ A;  2IBI A;  3O0U A;  3BOW A;  1BP4 A;  1JQP A;  3OVZ A;  4BQV A;  2GFO A;  4W5C A;  3AI8 A;  1KHP A;  3M99 A;  3KKU A;  1YVB A;  5K16 A;  2AVW A;  4QBB A;  2DZZ A;  3F75 A;  2R9M A;  3ZUA A;  4YVA A;  4YYW A;  1AU3 A;  1KFU L;  4W5B A;  2E00 A;  2DC7 A;  2YJ2 A;  2P0R A;  3IUT A;  1S4V A;  2DC6 A;  2H7J A;  3KWZ A;  5CHV A;  1ZCM A;  4GUZ A;  2DCA A;  1Q6K A;  1HUC B;  5PAD A;  2G6D A;  1CQD A;  2R6N A;  3D6S A;  4YV8 A;  4BGF A;  2G7Y A;  4YYR A;  3RVV A;  4QRV A;  2ARY A;  1U9Q X;  2R9C A;  2YJB A;  4B55 A;  2YJ8 A;  4Q8H A;  3I3T A;  4PP1 A;  1ITO A;  2JQF R;  2BDZ A;  1NPZ A;  1POP A;  5JH3 A;  1EWM A;  6PAD A;  2ATO A;  1PIP A;  3IHP A;  2XU3 A;  4I07 A;  1GMY A;  1F2B A;  1W4T A;  3P5V A;  2R9F A;  3MHH A;  4C5P A;  2P7U A;  1MS6 A;  3OIS A;  4Q8G A;  3PBH A;  4G54 A;  1BY8 A;  3PNR A;  3BPM A;  4RY2 A;  7PCK A;  1YT7 A;  1QOL A;  2HD5 A;  1A6R A;  5EF4 A;  1U5I A;  3H8C A;  1U9V A;  1Y4H A;  1AEC A;  3GCB A;  4X6J A;  1IWD A;  1QXP A;  4DMX A;  4P6G A;  3IOQ A;  2CB5 A;  3P5U A;  1X9Y A;  1NL6 A;  4OEM A;  1U9W A;  2FO5 A;  3WXE A;  1CSB B;  2FRQ A;  4FJC A;  2DC8 A;  3KW9 A;  3MOR A;  2AYN A;  2AU1 A;  3S3Q A;  1ME4 A;  4N8W A;  1EF7 A;  3N3K A;  2BSZ A;  3K9M A;  1AYW A;  2YJ9 A;  3KFQ A;  2GHU A;  2FYE A;  2P86 A;  3BWK A;  1BQI A;  3QT4 A;  2OP3 A;  3HHA A;  2XU1 A;  2AIM A;  4P6E A;  4XR7 A;  2NQG A;  2OZ2 A;  4K7C A;  4ZUX U;  2CIO A;  1PPP A;  5CVO B;  1K3B B;  1KXR A;  4NV7 A;  3H8B A;  1TL9 A;  4AXM A;  3V6E A;  3HWN A;  2F1G A;  2DCD A;  3NHE A;  3B79 A;  3D9W A;  4DMY A;  1VJV A;  2NQI A;  3CBJ A;  2PBH A;  4YYU A;  1PPO A;  5A24 A;  1AU0 A;  2C0Y A;  2PNS A;  2E02 A;  2NQD B;  2R9O A;  4FK5 A;  2FRA A;  4CDE B;  2DC9 A;  3KX1 A;  1YK7 A;  1W5R A;  3P5W A;  4QRX A;  1Y08 A;  2BDL A;  2XU5 A;  4PI3 A;  4YYS A;  1QMY A;  1MHW A;  2JQG R;  3S3R A;  3H6S A;  3E1Z B;  4N4Z A;  4I04 A;  1KHQ A;  4CDC B;  2AUZ A;  2E03 A;  2PAD A;  3K24 A;  1MEG A;  2AS8 A;  3CBK A;  2DZY A;  2AUX A;  3ERV A;  3HD3 A;  4FIP A;  2DCB A;  3MTN A;  3KSE A;  3LXS A;  3C9E A;  3BPF A;  2B1M A;  2VHS A;  1F2A A;  3K8U A;  4PP2 E;  4CDF B;  2FQ9 A;  1BGO A;  1NB3 A;  4WA6 A;  9PAP A;  1CTE A;  4AXL A;  1ME3 A;  4CDD B;  3QSD A;  1MIR A;  1EWL A;  3USV A;  2FTD A;  4BS6 A;  2YJC A;  3U8E A;  3HHI A;  1F29 A;  1TU6 A;  3O1G A;  4MZO A;  1PXV A;  3H7D A;  2G8E A;  3WXG A;  3CH3 X;  2O6X A;  4BSQ A;  1AYV A;  5CVM A;  1M6D A;  3H89 A;  1U9X A;  1GLO A;  1PAD A;  2DCC A;  4X6H A;  3OF9 A;  1XKG A;  3N3G A;  3IEJ A;  1YK8 A;  1CPJ A;  1W6F A;  3DF0 A;  1CS8 A;  2E01 A;  1KFX L;  2R9N A;  1E2T A;  5JA7 A;  1MDW A;  4X6I A;  1SP4 B;  1MEM A;  4NV8 A;  1FH0 A;  3LTW A;  5J94 A;  3BC3 A;  2G8J A;  2NQA A;  5F02 A;  4N79 A;  1AIM A;  4MSX A;  5EGW A;  1GCB A;  3IMA A;  3RVX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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