4PI3A

Crystal structure analysis of cruzain bound to vinyl sulfone analog of wrr-483 (wrr-666)
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Trypanosoma cruzi
molecule keywords Cruzipain
total genus 69
structure length 215
sequence length 215
chains with identical sequence B
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2014-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4pi3A00
4QRGA 3QSDA 3CBJA 4MSXA 3K9MA 1YT7A 1A6RA 5CVOB 2FYEA 3WXEA 2ARYA 2PADA 2YJBA 5A24A 3LFYA 1VJVA 3OVXA 1CS8A 1AECA 1BQIA 3S3RA 4MZOA 1DF0A 2B1MA 2XU1A 1BP4A 4I05A 1ATKA 3MHSA 1U9VA 1MIRA 1ZIVA 2HHNA 9PAPA 2GFOA 1S4VA 2DJFB 4PP2E 3BPFA 3KX1A 1NB3A 3O0UA 5PADA 1QOLA 1AU3A 1NL6A 2DCAA 2JQGR 2YJCA 3F75A 2F7DA 4YYVA 1YK8A 1AU2A 4CDFB 3BCNA 2AIMA 2AUZA 2AUXA 1X9YA 4PP1A 1ZCMA 4WA6A 1MS6A 1AYWA 8PCHA 5F02A 1NLJA 3I06A 3H7DA 1PPOA 3O1GA 3V6EA 2R9MA 3CH3X 2GHUA 5CHVA 1Y08A 1CB5A 4I07A 3IMAA 3IUTA 4FIPA 3PDFA 3P5WA 2HD5A 4CDCB 4Q8HA 1PCIA 3BOWA 3P5VA 2G7YA 3KWZA 2AVWA 3PW3A 1CTEA 1TL9A 1F29A 3TNXA 1JQPA 1AYUA 4YYRA 1KHPA 2OZ2A 4YV8A 1KXRA 4Q8GA 1FH0A 3QT4A 4P6GA 5EF4A 1U9QX 4BQVA 2OULA 1M6DA 1MEGA 5J94A 2PNSA 2PBHA 1Y4HA 2JQFR 4CZWA 5JA7A 1PXVA 2IBIA 2E00A 1GLOA 4QH6A 3BPMA 2CIOA 1QMYA 3N3KA 1POPA 2NQAA 3D6SA 1K3BB 4X6HA 3RVVA 3K8UA 5EGWA 4AXLA 3RVWA 4ZUXU 3IHPA 2P7UA 2FRQA 1ICFA 3C9EA 4QRVA 1CPJA 4RY2A 2ATOA 1GECE 3DF0A 2DC9A 3H89A 3KKUA 2P86A 1U9WA 1TU6A 4DMYA 1CQDA 2YJ9A 1MDWA 1PIPA 2IPPB 1GCBA 3OF8A 1IWDA 2XU3A 1XKGA 1YALA 2G8EA 4W4UA 2YJ2A 2FO5A 3PBHA 4AXMA 3ZUAA 4YYUA 1PADA 2DC6A 5FPWA 4BS6A 1YK7A 1AU4A 7PCKA 3MHHA 3H6SA 4QRXA 3LXSA 1F2BA 1YVBA 2C0YA 1PE6A 2E01A 1AIMA 1SNKA 3MTNA 2DCDA 4BS5A 3HWNA 3WXFA 1EWPA 1ME3A 2DJGB 2F1GA 1GMYA 2R9OA 4P6EA 1EF7A 3V6CA 3BWKA 1QDQA 3E1ZB 4OEMA 5K16A 3USVA 4X6JA 3OVZA 3GCBA 1TLOA 2XU4A 3S3QA 2R6NA 1EWMA 4X6IA 4I04A 1Q6KA 1KFUL 1CVZA 4W5BA 1MEMA 1PPDA 3CBKA 4CDDB 2FRAA 4PADA 1THEA 2FTDA 1AU0A 2AU1A 1CJLA 2DCCA 4MZSA 4FJCA 4YVAA 2DZYA 4KLBA 4BSQA 3N4CA 1ME4A 4YYWA 4DMXA 1STFE 2ACTA 2XU5A 2AS8A 2DCBA 2CB5A 3K24A 3OF9A 1VSNA 2H7JA 3IV2A 3KWBX 1NPZA 2E02A 3KW9A 4OELA 1MHWA 4G54A 4BPVA 1PPPA 3IOQA 4FK5A 1DEUA 1AYVA 3H8BA 1PPNA 2G8JA 3QJ3A 3IEJA 3WXGA 2OP3A 4YYQA 3MORA 4XR7A 2P0RA 3CH2X 2VHFA 1KHQA 1PBHA 1CV8A 2R9CA 2HXZA 3RVXA 2FT2A 2FUDA 2NQDB 3I3TA 2NQIA 2Y6EA 4CDEB 2DZZA 3P5UA 1KFXL 3PNRA 5CVNB 3N3GA 3AI8A 2BDZA 3KSEA 1BY8A 3HHAA 1U5IA 2O6XA 3F5VA 6PADA 2AYOA 3BC3A 1ITOA 4YYSA 1SP4B 3KFQA 2DC8A 4HWYA 3U8EA 1EWLA 2Y5BA 1QXPA 2R9NA 1F2AA 2AYNA 2HH5A 2VHSA 1F2CA 4N4ZA 3HHIA 2NQGA 5CVMA 3NHEA 3B79A 2YJ8A 1CSBB 2E03A 2WBFX 1BGOA 1HUCB 4QBBA 4W5CA 4XUIA 2B1NA 1NQCA 1U9XA 1EWOA 2PREA 2G6DA 2FQ9A 2R9FA 3H8CA 3OISA 5CHTA 5JH3A 2BDLA 4N8WA 3M99A 1O0EA 3HD3A 4K7CA 2DC7A 1NB5A 3P5XA 4PI3A 4N79A 3ERVA
chains in the Genus database with same CATH superfamily
4QRGA 3QSDA 3CBJA 4MSXA 3K9MA 1YT7A 1A6RA 5CVOB 3RNVA 2FYEA 1YZBA 3WXEA 4OVZA 2ARYA 2PADA 2YJBA 5A24A 3LFYA 1VJVA 3OVXA 1CS8A 5EZSA 1AECA 1BQIA 4BOSA 3S3RA 4MZOA 4M0WA 1DF0A 2B1MA 2XU1A 1BP4A 4D8EA 4I05A 1ATKA 3MHSA 3TRKA 1U9VA 1MIRA 1ZIVA 2HHNA 9PAPA 2GFOA 1S4VA 2DJFB 4PP2E 3BPFA 3KX1A 1NB3A 3IFUA 2J7QC 3O0UA 5PADA 1QOLA 1AU3A 1NL6A 3C0RA 2DCAA 2JQGR 2YJCA 3F75A 2F7DA 4YYVA 1YK8A 3BBAA 4HXDB 1AU2A 4CDFB 3BCNA 2AIMA 2AUZA 2AUXA 4BOZA 1X9YA 4PP1A 1ZCMA 4WA6A 1MS6A 1AYWA 3PHXA 8PCHA 5F02A 1NLJA 3I06A 3H7DA 1PPOA 3O1GA 3V6EA 2R9MA 3CH3X 2GHUA 5CHVA 1Y08A 1CB5A 4I07A 2BTWA 3IMAA 3IUTA 4FIPA 3PDFA 3P5WA 2HD5A 4CDCB 4OW0A 4A5UA 4Q8HA 1PCIA 3PSEA 3BOWA 3P5VA 2G7YA 3KWZA 2HWKA 2AVWA 4D8IA 3PW3A 2DOSA 1DKIA 1CTEA 1TL9A 4R3DA 1F29A 3TNXA 1JQPA 1AYUA 4YYRA 1KHPA 2OZ2A 4YV8A 1KXRA 4Q8GA 3PT2A 1FH0A 3QT4A 4P6GA 5EF4A 1U9QX 4REZA 4BQVA 2OULA 1M6DA 1MEGA 5J94A 2PNSA 2PBHA 4D8BA 1Y4HA 2JQFR 4CZWA 5JA7A 3MTVA 1PXVA 2IBIA 4WURA 2E00A 1GLOA 4QH6A 3BPMA 2CIOA 1QMYA 3N3KA 1POPA 2NQAA 3D6SA 3BB7A 1K3BB 4X6HA 3RVVA 4MI7A 3K8UA 5EGWA 4AXLA 3PRMA 3RVWA 4ZUXU 3IHPA 2P7UA 2FRQA 1ICFA 3C9EA 3W30A 4QRVA 1CPJA 4RY2A 2ATOA 1GECE 3DF0A 2DC9A 3H89A 3KKUA 2P86A 1U9WA 1TU6A 4DMYA 1CQDA 2YJ9A 1MDWA 4RF1A 1PIPA 2IPPB 1GCBA 3OF8A 1IWDA 2XU3A 2BU3A 1XKGA 1YALA 2G8EA 4W4UA 4BOUA 2YJ2A 2FO5A 3PBHA 4AXMA 4RF0A 4RNAA 3ZUAA 4PT5A 3PRPA 4YYUA 1PADA 2DC6A 5FPWA 4BS6A 1YK7A 1AU4A 7PCKA 3MHHA 3H6SA 4QRXA 3LXSA 1F2BA 1YVBA 2C0YA 1PE6A 2E01A 1AIMA 1SNKA 2FE8A 3MTNA 2DCDA 4BS5A 3HWNA 3WXFA 1EWPA 1ME3A 4XZXA 3MP2A 2DJGB 2F1GA 1GMYA 2R9OA 4P6EA 1EF7A 3V6CA 3BWKA 1QDQA 3E1ZB 4OEMA 5K16A 3USVA 4BOQA 4RKXA 4X6JA 3OVZA 3GCBA 1TLOA 2AGAA 2XU4A 3S3QA 2R6NA 1EWMA 4X6IA 4ZTBA 4I04A 1Q6KA 1KFUL 3PHUA 1CVZA 4W5BA 1MEMA 1PPDA 3CBKA 4CDDB 2FRAA 4PADA 1THEA 2FTDA 3W31A 1AU0A 2AU1A 1CJLA 2DCCA 4MZSA 4FJCA 4YVAA 2DZYA 4KLBA 4BSQA 3N4CA 1ME4A 4YYWA 4DMXA 5JZEA 1STFE 2ACTA 2XU5A 2AS8A 2DCBA 2CB5A 3K24A 3OF9A 5E6JA 1VSNA 2H7JA 3IV2A 3KWBX 1NPZA 2E02A 3E9SA 2BTWB 3KW9A 4OELA 1MHWA 4G54A 4BPVA 1PPPA 5KO3A 2JTCA 3IOQA 4FK5A 1DEUA 1AYVA 1PVJA 3H8BA 1PPNA 2G8JA 3QJ3A 3IEJA 4MM3B 3WXGA 2OP3A 4YYQA 3MORA 4XR7A 2P0RA 3CH2X 2VHFA 1KHQA 1PBHA 1CV8A 2R9CA 2HXZA 3RVXA 2FT2A 2FUDA 2NQDB 3I3TA 2NQIA 2Y6EA 4CDEB 2DZZA 3P5UA 2JRIA 1KFXL 3PNRA 3O65A 4OVZB 5CVNB 3N3GA 3AI8A 2BDZA 3KSEA 1BY8A 3HHAA 1U5IA 2O6XA 3F5VA 6PADA 2AYOA 3BC3A 1ITOA 4YYSA 3ZNHA 1SP4B 3KFQA 1UKFA 2DC8A 4HWYA 3U8EA 3BY4A 4IP3A 1EWLA 2Y5BA 1QXPA 2R9NA 2UZJA 1F2AA 5EZQA 4IUMA 2AYNA 2HH5A 3TMPA 2VHSA 3MJ5A 2Z84A 1F2CA 4N4ZA 3HHIA 2NQGA 5CVMA 3NHEA 3B79A 2YJ8A 1CSBB 4BOPA 3OQCA 2E03A 2WBFX 1BGOA 1HUCB 4P16A 4QBBA 4W5CA 4XUIA 2B1NA 1NQCA 1U9XA 1EWOA 2PREA 2G6DA 3B21A 2FQ9A 2R9FA 3H8CA 3OISA 5CHTA 5JH3A 2BDLA 4N8WA 3M99A 1O0EA 2J7QA 3HD3A 3PHWA 2DC7A 4K7CA 1NB5A 4GUAA 3P5XA 4PI3A 4N79A 3ERVA
chains in the Genus database with same CATH topology
4QRGA 3QSDA 3CBJA 4MSXA 3K9MA 1YT7A 1A6RA 5CVOB 2FYEA 3WXEA 2ARYA 2PADA 2YJBA 5A24A 3LFYA 1VJVA 3OVXA 1CS8A 4GUZA 1AECA 1BQIA 3S3RA 4MZOA 1E2TA 1DF0A 2B1MA 2XU1A 1BP4A 4I05A 1ATKA 3MHSA 1U9VA 1MIRA 1ZIVA 2HHNA 9PAPA 2GFOA 1S4VA 2DJFB 4PP2E 3BPFA 3KX1A 1NB3A 3O0UA 5PADA 1QOLA 1AU3A 1NL6A 2DCAA 2JQGR 2YJCA 3F75A 2F7DA 4YYVA 1YK8A 1GX3A 1AU2A 4CDFB 3BCNA 2AIMA 2AUZA 2AUXA 1X9YA 4PP1A 1ZCMA 4WA6A 1MS6A 1AYWA 8PCHA 5F02A 1NLJA 3I06A 3H7DA 1PPOA 3O1GA 3V6EA 2R9MA 3CH3X 2GHUA 5CHVA 1Y08A 1CB5A 4I07A 3IMAA 3IUTA 4FIPA 3PDFA 3P5WA 2HD5A 4CDCB 4Q8HA 1PCIA 3BOWA 3P5VA 2G7YA 3KWZA 2AVWA 3PW3A 1CTEA 1TL9A 1F29A 3TNXA 1JQPA 3LTWA 1AYUA 4YYRA 1KHPA 2OZ2A 2BSZA 4YV8A 1KXRA 4Q8GA 1FH0A 3QT4A 4P6GA 5EF4A 1U9QX 4BQVA 2OULA 1M6DA 1MEGA 5J94A 2PNSA 2PBHA 1Y4HA 2JQFR 4CZWA 5JA7A 1PXVA 2IBIA 2E00A 1GLOA 4QH6A 3BPMA 2CIOA 1QMYA 3N3KA 1POPA 2NQAA 3D6SA 1K3BB 4X6HA 3RVVA 3K8UA 5EGWA 4AXLA 4BGFA 3RVWA 4ZUXU 3IHPA 2P7UA 2FRQA 1ICFA 3C9EA 4QRVA 1CPJA 4RY2A 2ATOA 1GECE 3DF0A 2DC9A 3H89A 3KKUA 2P86A 1U9WA 1TU6A 4DMYA 1CQDA 2YJ9A 1MDWA 2VFCA 1PIPA 2IPPB 1GCBA 3OF8A 4C5PA 1IWDA 2XU3A 1XKGA 1YALA 2G8EA 4W4UA 2YJ2A 4NV8A 2FO5A 3PBHA 4AXMA 3ZUAA 4YYUA 1PADA 2DC6A 5FPWA 4BS6A 1YK7A 1AU4A 7PCKA 2VFBA 3MHHA 3H6SA 4QRXA 3LXSA 1F2BA 1YVBA 2C0YA 1PE6A 2E01A 1AIMA 1SNKA 3MTNA 2DCDA 4BS5A 3HWNA 3WXFA 1EWPA 1ME3A 1W4TA 2DJGB 1W5RA 2F1GA 1GMYA 2R9OA 4P6EA 1EF7A 3V6CA 3BWKA 1QDQA 3E1ZB 4OEMA 5K16A 3USVA 4NV7A 4X6JA 3OVZA 3GCBA 1TLOA 2XU4A 3S3QA 2R6NA 1EWMA 4X6IA 4I04A 1Q6KA 1KFUL 1CVZA 4W5BA 1MEMA 1PPDA 3CBKA 4CDDB 2FRAA 4PADA 1THEA 2FTDA 1AU0A 2AU1A 1CJLA 2DCCA 4MZSA 4FJCA 4YVAA 2DZYA 4KLBA 4BSQA 3N4CA 1ME4A 4YYWA 4DMXA 1STFE 2ACTA 2XU5A 2AS8A 2DCBA 2CB5A 3K24A 3OF9A 1VSNA 2H7JA 3IV2A 3KWBX 1NPZA 2E02A 3KW9A 4OELA 1MHWA 4G54A 4BPVA 1PPPA 3IOQA 4FK5A 1DEUA 1AYVA 3H8BA 1PPNA 2G8JA 3QJ3A 3IEJA 3WXGA 2OP3A 4YYQA 3MORA 4XR7A 2P0RA 3CH2X 2VHFA 1KHQA 1PBHA 1CV8A 2R9CA 2HXZA 3RVXA 2FT2A 2FUDA 2NQDB 3I3TA 2NQIA 2Y6EA 3D9WA 4CDEB 2DZZA 3P5UA 1KFXL 3PNRA 5CVNB 3N3GA 3AI8A 2BDZA 3KSEA 1BY8A 3HHAA 1U5IA 2O6XA 3F5VA 6PADA 2AYOA 3BC3A 1ITOA 1W6FA 4YYSA 4B55A 1SP4B 3KFQA 2DC8A 4HWYA 3U8EA 1EWLA 2Y5BA 1QXPA 2R9NA 1F2AA 2AYNA 2HH5A 2VHSA 1F2CA 4N4ZA 3HHIA 2NQGA 5CVMA 3NHEA 3B79A 2YJ8A 1CSBB 2E03A 2WBFX 1BGOA 1HUCB 4QBBA 4W5CA 4XUIA 2B1NA 1NQCA 1U9XA 1EWOA 2PREA 2G6DA 2FQ9A 2R9FA 3H8CA 3OISA 5CHTA 5JH3A 2BDLA 4N8WA 3M99A 1O0EA 3HD3A 4K7CA 2DC7A 1NB5A 3P5XA 4PI3A 4N79A 3ERVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QRG A;  3QSD A;  3CBJ A;  4MSX A;  3K9M A;  1YT7 A;  1A6R A;  5CVO B;  2FYE A;  3WXE A;  2ARY A;  2PAD A;  2YJB A;  5A24 A;  3LFY A;  1VJV A;  3OVX A;  1CS8 A;  1AEC A;  1BQI A;  3S3R A;  4MZO A;  1DF0 A;  2B1M A;  2XU1 A;  1BP4 A;  4I05 A;  1ATK A;  3MHS A;  1U9V A;  1MIR A;  1ZIV A;  2HHN A;  9PAP A;  2GFO A;  1S4V A;  2DJF B;  4PP2 E;  3BPF A;  3KX1 A;  1NB3 A;  3O0U A;  5PAD A;  1QOL A;  1AU3 A;  1NL6 A;  2DCA A;  2JQG R;  2YJC A;  3F75 A;  2F7D A;  4YYV A;  1YK8 A;  1AU2 A;  4CDF B;  3BCN A;  2AIM A;  2AUZ A;  2AUX A;  1X9Y A;  4PP1 A;  1ZCM A;  4WA6 A;  1MS6 A;  1AYW A;  8PCH A;  5F02 A;  1NLJ A;  3I06 A;  3H7D A;  1PPO A;  3O1G A;  3V6E A;  2R9M A;  3CH3 X;  2GHU A;  5CHV A;  1Y08 A;  1CB5 A;  4I07 A;  3IMA A;  3IUT A;  4FIP A;  3PDF A;  3P5W A;  2HD5 A;  4CDC B;  4Q8H A;  1PCI A;  3BOW A;  3P5V A;  2G7Y A;  3KWZ A;  2AVW A;  3PW3 A;  1CTE A;  1TL9 A;  1F29 A;  3TNX A;  1JQP A;  1AYU A;  4YYR A;  1KHP A;  2OZ2 A;  4YV8 A;  1KXR A;  4Q8G A;  1FH0 A;  3QT4 A;  4P6G A;  5EF4 A;  1U9Q X;  4BQV A;  2OUL A;  1M6D A;  1MEG A;  5J94 A;  2PNS A;  2PBH A;  1Y4H A;  2JQF R;  4CZW A;  5JA7 A;  1PXV A;  2IBI A;  2E00 A;  1GLO A;  4QH6 A;  3BPM A;  2CIO A;  1QMY A;  3N3K A;  1POP A;  2NQA A;  3D6S A;  1K3B B;  4X6H A;  3RVV A;  3K8U A;  5EGW A;  4AXL A;  3RVW A;  4ZUX U;  3IHP A;  2P7U A;  2FRQ A;  1ICF A;  3C9E A;  4QRV A;  1CPJ A;  4RY2 A;  2ATO A;  1GEC E;  3DF0 A;  2DC9 A;  3H89 A;  3KKU A;  2P86 A;  1U9W A;  1TU6 A;  4DMY A;  1CQD A;  2YJ9 A;  1MDW A;  1PIP A;  2IPP B;  1GCB A;  3OF8 A;  1IWD A;  2XU3 A;  1XKG A;  1YAL A;  2G8E A;  4W4U A;  2YJ2 A;  2FO5 A;  3PBH A;  4AXM A;  3ZUA A;  4YYU A;  1PAD A;  2DC6 A;  5FPW A;  4BS6 A;  1YK7 A;  1AU4 A;  7PCK A;  3MHH A;  3H6S A;  4QRX A;  3LXS A;  1F2B A;  1YVB A;  2C0Y A;  1PE6 A;  2E01 A;  1AIM A;  1SNK A;  3MTN A;  2DCD A;  4BS5 A;  3HWN A;  3WXF A;  1EWP A;  1ME3 A;  2DJG B;  2F1G A;  1GMY A;  2R9O A;  4P6E A;  1EF7 A;  3V6C A;  3BWK A;  1QDQ A;  3E1Z B;  4OEM A;  5K16 A;  3USV A;  4X6J A;  3OVZ A;  3GCB A;  1TLO A;  2XU4 A;  3S3Q A;  2R6N A;  1EWM A;  4X6I A;  4I04 A;  1Q6K A;  1KFU L;  1CVZ A;  4W5B A;  1MEM A;  1PPD A;  3CBK A;  4CDD B;  2FRA A;  4PAD A;  1THE A;  2FTD A;  1AU0 A;  2AU1 A;  1CJL A;  2DCC A;  4MZS A;  4FJC A;  4YVA A;  2DZY A;  4KLB A;  4BSQ A;  3N4C A;  1ME4 A;  4YYW A;  4DMX A;  1STF E;  2ACT A;  2XU5 A;  2AS8 A;  2DCB A;  2CB5 A;  3K24 A;  3OF9 A;  1VSN A;  2H7J A;  3IV2 A;  3KWB X;  1NPZ A;  2E02 A;  3KW9 A;  4OEL A;  1MHW A;  4G54 A;  4BPV A;  1PPP A;  3IOQ A;  4FK5 A;  1DEU A;  1AYV A;  3H8B A;  1PPN A;  2G8J A;  3QJ3 A;  3IEJ A;  3WXG A;  2OP3 A;  4YYQ A;  3MOR A;  4XR7 A;  2P0R A;  3CH2 X;  2VHF A;  1KHQ A;  1PBH A;  1CV8 A;  2R9C A;  2HXZ A;  3RVX A;  2FT2 A;  2FUD A;  2NQD B;  3I3T A;  2NQI A;  2Y6E A;  4CDE B;  2DZZ A;  3P5U A;  1KFX L;  3PNR A;  5CVN B;  3N3G A;  3AI8 A;  2BDZ A;  3KSE A;  1BY8 A;  3HHA A;  1U5I A;  2O6X A;  3F5V A;  6PAD A;  2AYO A;  3BC3 A;  1ITO A;  4YYS A;  1SP4 B;  3KFQ A;  2DC8 A;  4HWY A;  3U8E A;  1EWL A;  2Y5B A;  1QXP A;  2R9N A;  1F2A A;  2AYN A;  2HH5 A;  2VHS A;  1F2C A;  4N4Z A;  3HHI A;  2NQG A;  5CVM A;  3NHE A;  3B79 A;  2YJ8 A;  1CSB B;  2E03 A;  2WBF X;  1BGO A;  1HUC B;  4QBB A;  4W5C A;  4XUI A;  2B1N A;  1NQC A;  1U9X A;  1EWO A;  2PRE A;  2G6D A;  2FQ9 A;  2R9F A;  3H8C A;  3OIS A;  5CHT A;  5JH3 A;  2BDL A;  4N8W A;  3M99 A;  1O0E A;  3HD3 A;  4K7C A;  2DC7 A;  1NB5 A;  3P5X A;  4PI3 A;  4N79 A;  3ERV A; 
#chains in the Genus database with same CATH topology
 4QRG A;  3QSD A;  3CBJ A;  4MSX A;  3K9M A;  1YT7 A;  1A6R A;  5CVO B;  3RNV A;  2FYE A;  1YZB A;  3WXE A;  4OVZ A;  2ARY A;  2PAD A;  2YJB A;  5A24 A;  3LFY A;  1VJV A;  3OVX A;  1CS8 A;  5EZS A;  1AEC A;  1BQI A;  4BOS A;  3S3R A;  4MZO A;  4M0W A;  1DF0 A;  2B1M A;  2XU1 A;  1BP4 A;  4D8E A;  4I05 A;  1ATK A;  3MHS A;  3TRK A;  1U9V A;  1MIR A;  1ZIV A;  2HHN A;  9PAP A;  2GFO A;  1S4V A;  2DJF B;  4PP2 E;  3BPF A;  3KX1 A;  1NB3 A;  3IFU A;  2J7Q C;  3O0U A;  5PAD A;  1QOL A;  1AU3 A;  1NL6 A;  3C0R A;  2DCA A;  2JQG R;  2YJC A;  3F75 A;  2F7D A;  4YYV A;  1YK8 A;  3BBA A;  4HXD B;  1AU2 A;  4CDF B;  3BCN A;  2AIM A;  2AUZ A;  2AUX A;  4BOZ A;  1X9Y A;  4PP1 A;  1ZCM A;  4WA6 A;  1MS6 A;  1AYW A;  3PHX A;  8PCH A;  5F02 A;  1NLJ A;  3I06 A;  3H7D A;  1PPO A;  3O1G A;  3V6E A;  2R9M A;  3CH3 X;  2GHU A;  5CHV A;  1Y08 A;  1CB5 A;  4I07 A;  2BTW A;  3IMA A;  3IUT A;  4FIP A;  3PDF A;  3P5W A;  2HD5 A;  4CDC B;  4OW0 A;  4A5U A;  4Q8H A;  1PCI A;  3PSE A;  3BOW A;  3P5V A;  2G7Y A;  3KWZ A;  2HWK A;  2AVW A;  4D8I A;  3PW3 A;  2DOS A;  1DKI A;  1CTE A;  1TL9 A;  4R3D A;  1F29 A;  3TNX A;  1JQP A;  1AYU A;  4YYR A;  1KHP A;  2OZ2 A;  4YV8 A;  1KXR A;  4Q8G A;  3PT2 A;  1FH0 A;  3QT4 A;  4P6G A;  5EF4 A;  1U9Q X;  4REZ A;  4BQV A;  2OUL A;  1M6D A;  1MEG A;  5J94 A;  2PNS A;  2PBH A;  4D8B A;  1Y4H A;  2JQF R;  4CZW A;  5JA7 A;  3MTV A;  1PXV A;  2IBI A;  4WUR A;  2E00 A;  1GLO A;  4QH6 A;  3BPM A;  2CIO A;  1QMY A;  3N3K A;  1POP A;  2NQA A;  3D6S A;  3BB7 A;  1K3B B;  4X6H A;  3RVV A;  4MI7 A;  3K8U A;  5EGW A;  4AXL A;  3PRM A;  3RVW A;  4ZUX U;  3IHP A;  2P7U A;  2FRQ A;  1ICF A;  3C9E A;  3W30 A;  4QRV A;  1CPJ A;  4RY2 A;  2ATO A;  1GEC E;  3DF0 A;  2DC9 A;  3H89 A;  3KKU A;  2P86 A;  1U9W A;  1TU6 A;  4DMY A;  1CQD A;  2YJ9 A;  1MDW A;  4RF1 A;  1PIP A;  2IPP B;  1GCB A;  3OF8 A;  1IWD A;  2XU3 A;  2BU3 A;  1XKG A;  1YAL A;  2G8E A;  4W4U A;  4BOU A;  2YJ2 A;  2FO5 A;  3PBH A;  4AXM A;  4RF0 A;  4RNA A;  3ZUA A;  4PT5 A;  3PRP A;  4YYU A;  1PAD A;  2DC6 A;  5FPW A;  4BS6 A;  1YK7 A;  1AU4 A;  7PCK A;  3MHH A;  3H6S A;  4QRX A;  3LXS A;  1F2B A;  1YVB A;  2C0Y A;  1PE6 A;  2E01 A;  1AIM A;  1SNK A;  2FE8 A;  3MTN A;  2DCD A;  4BS5 A;  3HWN A;  3WXF A;  1EWP A;  1ME3 A;  4XZX A;  3MP2 A;  2DJG B;  2F1G A;  1GMY A;  2R9O A;  4P6E A;  1EF7 A;  3V6C A;  3BWK A;  1QDQ A;  3E1Z B;  4OEM A;  5K16 A;  3USV A;  4BOQ A;  4RKX A;  4X6J A;  3OVZ A;  3GCB A;  1TLO A;  2AGA A;  2XU4 A;  3S3Q A;  2R6N A;  1EWM A;  4X6I A;  4ZTB A;  4I04 A;  1Q6K A;  1KFU L;  3PHU A;  1CVZ A;  4W5B A;  1MEM A;  1PPD A;  3CBK A;  4CDD B;  2FRA A;  4PAD A;  1THE A;  2FTD A;  3W31 A;  1AU0 A;  2AU1 A;  1CJL A;  2DCC A;  4MZS A;  4FJC A;  4YVA A;  2DZY A;  4KLB A;  4BSQ A;  3N4C A;  1ME4 A;  4YYW A;  4DMX A;  5JZE A;  1STF E;  2ACT A;  2XU5 A;  2AS8 A;  2DCB A;  2CB5 A;  3K24 A;  3OF9 A;  5E6J A;  1VSN A;  2H7J A;  3IV2 A;  3KWB X;  1NPZ A;  2E02 A;  3E9S A;  2BTW B;  3KW9 A;  4OEL A;  1MHW A;  4G54 A;  4BPV A;  1PPP A;  5KO3 A;  2JTC A;  3IOQ A;  4FK5 A;  1DEU A;  1AYV A;  1PVJ A;  3H8B A;  1PPN A;  2G8J A;  3QJ3 A;  3IEJ A;  4MM3 B;  3WXG A;  2OP3 A;  4YYQ A;  3MOR A;  4XR7 A;  2P0R A;  3CH2 X;  2VHF A;  1KHQ A;  1PBH A;  1CV8 A;  2R9C A;  2HXZ A;  3RVX A;  2FT2 A;  2FUD A;  2NQD B;  3I3T A;  2NQI A;  2Y6E A;  4CDE B;  2DZZ A;  3P5U A;  2JRI A;  1KFX L;  3PNR A;  3O65 A;  4OVZ B;  5CVN B;  3N3G A;  3AI8 A;  2BDZ A;  3KSE A;  1BY8 A;  3HHA A;  1U5I A;  2O6X A;  3F5V A;  6PAD A;  2AYO A;  3BC3 A;  1ITO A;  4YYS A;  3ZNH A;  1SP4 B;  3KFQ A;  1UKF A;  2DC8 A;  4HWY A;  3U8E A;  3BY4 A;  4IP3 A;  1EWL A;  2Y5B A;  1QXP A;  2R9N A;  2UZJ A;  1F2A A;  5EZQ A;  4IUM A;  2AYN A;  2HH5 A;  3TMP A;  2VHS A;  3MJ5 A;  2Z84 A;  1F2C A;  4N4Z A;  3HHI A;  2NQG A;  5CVM A;  3NHE A;  3B79 A;  2YJ8 A;  1CSB B;  4BOP A;  3OQC A;  2E03 A;  2WBF X;  1BGO A;  1HUC B;  4P16 A;  4QBB A;  4W5C A;  4XUI A;  2B1N A;  1NQC A;  1U9X A;  1EWO A;  2PRE A;  2G6D A;  3B21 A;  2FQ9 A;  2R9F A;  3H8C A;  3OIS A;  5CHT A;  5JH3 A;  2BDL A;  4N8W A;  3M99 A;  1O0E A;  2J7Q A;  3HD3 A;  3PHW A;  2DC7 A;  4K7C A;  1NB5 A;  4GUA A;  3P5X A;  4PI3 A;  4N79 A;  3ERV A; 
#chains in the Genus database with same CATH homology
 4QRG A;  3QSD A;  3CBJ A;  4MSX A;  3K9M A;  1YT7 A;  1A6R A;  5CVO B;  2FYE A;  3WXE A;  2ARY A;  2PAD A;  2YJB A;  5A24 A;  3LFY A;  1VJV A;  3OVX A;  1CS8 A;  4GUZ A;  1AEC A;  1BQI A;  3S3R A;  4MZO A;  1E2T A;  1DF0 A;  2B1M A;  2XU1 A;  1BP4 A;  4I05 A;  1ATK A;  3MHS A;  1U9V A;  1MIR A;  1ZIV A;  2HHN A;  9PAP A;  2GFO A;  1S4V A;  2DJF B;  4PP2 E;  3BPF A;  3KX1 A;  1NB3 A;  3O0U A;  5PAD A;  1QOL A;  1AU3 A;  1NL6 A;  2DCA A;  2JQG R;  2YJC A;  3F75 A;  2F7D A;  4YYV A;  1YK8 A;  1GX3 A;  1AU2 A;  4CDF B;  3BCN A;  2AIM A;  2AUZ A;  2AUX A;  1X9Y A;  4PP1 A;  1ZCM A;  4WA6 A;  1MS6 A;  1AYW A;  8PCH A;  5F02 A;  1NLJ A;  3I06 A;  3H7D A;  1PPO A;  3O1G A;  3V6E A;  2R9M A;  3CH3 X;  2GHU A;  5CHV A;  1Y08 A;  1CB5 A;  4I07 A;  3IMA A;  3IUT A;  4FIP A;  3PDF A;  3P5W A;  2HD5 A;  4CDC B;  4Q8H A;  1PCI A;  3BOW A;  3P5V A;  2G7Y A;  3KWZ A;  2AVW A;  3PW3 A;  1CTE A;  1TL9 A;  1F29 A;  3TNX A;  1JQP A;  3LTW A;  1AYU A;  4YYR A;  1KHP A;  2OZ2 A;  2BSZ A;  4YV8 A;  1KXR A;  4Q8G A;  1FH0 A;  3QT4 A;  4P6G A;  5EF4 A;  1U9Q X;  4BQV A;  2OUL A;  1M6D A;  1MEG A;  5J94 A;  2PNS A;  2PBH A;  1Y4H A;  2JQF R;  4CZW A;  5JA7 A;  1PXV A;  2IBI A;  2E00 A;  1GLO A;  4QH6 A;  3BPM A;  2CIO A;  1QMY A;  3N3K A;  1POP A;  2NQA A;  3D6S A;  1K3B B;  4X6H A;  3RVV A;  3K8U A;  5EGW A;  4AXL A;  4BGF A;  3RVW A;  4ZUX U;  3IHP A;  2P7U A;  2FRQ A;  1ICF A;  3C9E A;  4QRV A;  1CPJ A;  4RY2 A;  2ATO A;  1GEC E;  3DF0 A;  2DC9 A;  3H89 A;  3KKU A;  2P86 A;  1U9W A;  1TU6 A;  4DMY A;  1CQD A;  2YJ9 A;  1MDW A;  2VFC A;  1PIP A;  2IPP B;  1GCB A;  3OF8 A;  4C5P A;  1IWD A;  2XU3 A;  1XKG A;  1YAL A;  2G8E A;  4W4U A;  2YJ2 A;  4NV8 A;  2FO5 A;  3PBH A;  4AXM A;  3ZUA A;  4YYU A;  1PAD A;  2DC6 A;  5FPW A;  4BS6 A;  1YK7 A;  1AU4 A;  7PCK A;  2VFB A;  3MHH A;  3H6S A;  4QRX A;  3LXS A;  1F2B A;  1YVB A;  2C0Y A;  1PE6 A;  2E01 A;  1AIM A;  1SNK A;  3MTN A;  2DCD A;  4BS5 A;  3HWN A;  3WXF A;  1EWP A;  1ME3 A;  1W4T A;  2DJG B;  1W5R A;  2F1G A;  1GMY A;  2R9O A;  4P6E A;  1EF7 A;  3V6C A;  3BWK A;  1QDQ A;  3E1Z B;  4OEM A;  5K16 A;  3USV A;  4NV7 A;  4X6J A;  3OVZ A;  3GCB A;  1TLO A;  2XU4 A;  3S3Q A;  2R6N A;  1EWM A;  4X6I A;  4I04 A;  1Q6K A;  1KFU L;  1CVZ A;  4W5B A;  1MEM A;  1PPD A;  3CBK A;  4CDD B;  2FRA A;  4PAD A;  1THE A;  2FTD A;  1AU0 A;  2AU1 A;  1CJL A;  2DCC A;  4MZS A;  4FJC A;  4YVA A;  2DZY A;  4KLB A;  4BSQ A;  3N4C A;  1ME4 A;  4YYW A;  4DMX A;  1STF E;  2ACT A;  2XU5 A;  2AS8 A;  2DCB A;  2CB5 A;  3K24 A;  3OF9 A;  1VSN A;  2H7J A;  3IV2 A;  3KWB X;  1NPZ A;  2E02 A;  3KW9 A;  4OEL A;  1MHW A;  4G54 A;  4BPV A;  1PPP A;  3IOQ A;  4FK5 A;  1DEU A;  1AYV A;  3H8B A;  1PPN A;  2G8J A;  3QJ3 A;  3IEJ A;  3WXG A;  2OP3 A;  4YYQ A;  3MOR A;  4XR7 A;  2P0R A;  3CH2 X;  2VHF A;  1KHQ A;  1PBH A;  1CV8 A;  2R9C A;  2HXZ A;  3RVX A;  2FT2 A;  2FUD A;  2NQD B;  3I3T A;  2NQI A;  2Y6E A;  3D9W A;  4CDE B;  2DZZ A;  3P5U A;  1KFX L;  3PNR A;  5CVN B;  3N3G A;  3AI8 A;  2BDZ A;  3KSE A;  1BY8 A;  3HHA A;  1U5I A;  2O6X A;  3F5V A;  6PAD A;  2AYO A;  3BC3 A;  1ITO A;  1W6F A;  4YYS A;  4B55 A;  1SP4 B;  3KFQ A;  2DC8 A;  4HWY A;  3U8E A;  1EWL A;  2Y5B A;  1QXP A;  2R9N A;  1F2A A;  2AYN A;  2HH5 A;  2VHS A;  1F2C A;  4N4Z A;  3HHI A;  2NQG A;  5CVM A;  3NHE A;  3B79 A;  2YJ8 A;  1CSB B;  2E03 A;  2WBF X;  1BGO A;  1HUC B;  4QBB A;  4W5C A;  4XUI A;  2B1N A;  1NQC A;  1U9X A;  1EWO A;  2PRE A;  2G6D A;  2FQ9 A;  2R9F A;  3H8C A;  3OIS A;  5CHT A;  5JH3 A;  2BDL A;  4N8W A;  3M99 A;  1O0E A;  3HD3 A;  4K7C A;  2DC7 A;  1NB5 A;  3P5X A;  4PI3 A;  4N79 A;  3ERV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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