3TMPA

The catalytic domain of human deubiquitinase duba in complex with ubiquitin aldehyde
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
169
structure length
165
Chain Sequence
AGYNEDEYEAAAARIDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTGTSAVEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Phosphorylation-dependent activity of the deubiquitinase DUBA.
pubmed doi rcsb
molecule tags Hydrolase/protein binding
source organism Homo sapiens
molecule keywords OTU domain-containing protein 5
total genus 57
structure length 165
sequence length 169
chains with identical sequence C, E, G
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2011-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02338 OTU OTU-like cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.80 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 3tmpA01
3PRMA 3PSEA 3BY4A 3PRPA 3PHUA 4HXDB 3PHXA 4BOSA 3ZNHA 4BOZA 3PT2A 3TMPA 4BOQA 4BOUA 3C0RA 5JZEA 4BOPA 3PHWA
chains in the Genus database with same CATH superfamily
1VJVA 3N3GA 4Q8HA 3KFQA 4W5BA 5CVOB 4OVZA 2AYOA 3P5XA 2AS8A 1PIPA 3IEJA 3KX1A 2NQDB 1A6RA 5CHVA 1CS8A 5KO3A 1ICFA 1GCBA 1NQCA 1U5IA 3OF8A 3O65A 1ATKA 2R9MA 8PCHA 5JZEA 1PPDA 3DF0A 4M0WA 4BOQA 3RVVA 3O1GA 2FT2A 1U9VA 4FJCA 1MIRA 3N4CA 4RKXA 2BDZA 1AU0A 4HWYA 4X6JA 4BPVA 1ZCMA 3CBKA 3MORA 4D8BA 3S3QA 2DOSA 1KFXL 1PCIA 1U9QX 4D8IA 2GFOA 1CQDA 5J94A 1U9XA 3MHSA 1GECE 1SP4B 4YYUA 2YJ2A 4IUMA 1PADA 2B1MA 1VSNA 1NB3A 3CH3X 4I07A 2E01A 3K9MA 3WXGA 1AU4A 1PPOA 2AU1A 2AIMA 3QJ3A 4PI3A 4K7CA 2UZJA 4YV8A 4DMYA 4CDCB 4QH6A 4RNAA 3ZUAA 1TLOA 2Y5BA 1GLOA 1CTEA 2F1GA 3RNVA 3IOQA 1ME4A 4FIPA 3W31A 1K3BB 3E1ZB 3BOWA 5CHTA 1YZBA 1NLJA 2YJBA 4QBBA 4CZWA 3CBJA 4W4UA 2G6DA 2JQGR 3I3TA 3PHWA 5CVMA 4BS6A 1NPZA 1AIMA 5PADA 3MP2A 4X6HA 4A5UA 1Y08A 4N4ZA 2FRAA 2YJCA 1YVBA 1U9WA 2VHFA 3GCBA 3U8EA 1PPNA 4CDEB 2AUXA 1MEGA 4BOZA 4AXLA 3E9SA 2AVWA 2DCBA 1TU6A 4PP2E 2NQGA 3QT4A 4I05A 2ARYA 1AYVA 2JTCA 3PSEA 1TL9A 3LXSA 2P0RA 3CH2X 1AU2A 1MEMA 4RF1A 2YJ9A 3PHXA 4XUIA 4QRGA 3TMPA 4OVZB 1NL6A 1MS6A 3ERVA 3OVZA 2J7QA 4IP3A 3WXFA 1CV8A 2FTDA 3MTNA 1AU3A 2B1NA 2OZ2A 4YYVA 1PE6A 1FH0A 4REZA 1QOLA 1BY8A 4KLBA 2ATOA 1QDQA 4WA6A 2IBIA 3OF9A 4XZXA 3PBHA 1YK7A 4X6IA 2PBHA 4YYSA 4YVAA 3BY4A 5CVNB 4QRXA 2E00A 2FE8A 2XU1A 3PT2A 3PDFA 2DC6A 2DCCA 2DC7A 3HD3A 3B79A 2H7JA 5F02A 3H8BA 2GHUA 4FK5A 1Q6KA 4N79A 3PNRA 1MDWA 2O6XA 3P5UA 4N8WA 1EWPA 4RY2A 2BTWA 3NHEA 2FRQA 4DMXA 4R3DA 4OW0A 2AUZA 1DKIA 2BTWB 3PRPA 2Z84A 1ZIVA 2AGAA 5E6JA 2R9NA 4BQVA 4ZUXU 2DZZA 1QXPA 2DCDA 2E02A 2PNSA 3BB7A 4BSQA 1PVJA 4QRVA 1EWMA 2JQFR 1AYWA 3F5VA 2YJ8A 3IMAA 3IUTA 4GUAA 4P16A 1YALA 2DCAA 1XKGA 1THEA 2R9OA 3IHPA 4P6GA 4PT5A 3KKUA 1JQPA 3V6EA 3WXEA 4XR7A 2R9FA 2HHNA 3PHUA 2P7UA 3KWZA 3B21A 3M99A 9PAPA 5EZQA 2HWKA 4WURA 4MZOA 4PADA 2CIOA 3HHAA 3K24A 3IV2A 6PADA 2XU3A 4YYRA 4HXDB 3H6SA 1QMYA 7PCKA 4W5CA 1IWDA 1ITOA 3BPFA 3RVWA 3S3RA 2BDLA 1BP4A 3MJ5A 1YK8A 2FO5A 2OP3A 1F2CA 1KXRA 2FYEA 2E03A 2R9CA 1M6DA 3LFYA 5JA7A 1O0EA 2HD5A 3C9EA 2FQ9A 1POPA 3OQCA 4CDDB 2DC8A 1STFE 1NB5A 1PBHA 3OISA 1EWOA 1YT7A 1F29A 2AYNA 2XU5A 1F2BA 2HXZA 3O0UA 4RF0A 1CVZA 3RVXA 3TNXA 2DJFB 2DJGB 3V6CA 2CB5A 4ZTBA 1KFUL 1DEUA 3H8CA 3ZNHA 4BOUA 4PP1A 3PW3A 4BOPA 1EF7A 1CB5A 4OELA 3IFUA 3HWNA 3BWKA 4MI7A 2P86A 4D8EA 2VHSA 1CJLA 2G8JA 3I06A 3BBAA 4G54A 1AYUA 3C0RA 2NQAA 5K16A 4MM3B 2PADA 3P5WA 2XU4A 2Y6EA 4Q8GA 4OEMA 5EZSA 1CSBB 3H7DA 2ACTA 2DC9A 2HH5A 2JRIA 1CPJA 2IPPB 2WBFX 3KWBX 3AI8A 3QSDA 3USVA 3KW9A 2DZYA 3BC3A 1X9YA 4BS5A 3KSEA 4YYQA 3TRKA 4BOSA 3HHIA 4AXMA 4CDFB 4MZSA 1AECA 2BU3A 2OULA 3K8UA 4I04A 3D6SA 2C0YA 1HUCB 3PRMA 5FPWA 5A24A 1PPPA 4MSXA 1DF0A 1GMYA 1Y4HA 1MHWA 2G8EA 2G7YA 1SNKA 1BQIA 5EGWA 3MTVA 3W30A 1KHPA 3H89A 1F2AA 3OVXA 3F75A 5JH3A 1UKFA 3N3KA 2FUDA 1BGOA 1S4VA 1PXVA 3BPMA 1EWLA 1ME3A 4P6EA 5EF4A 3BCNA 1KHQA 2R6NA 3MHHA 2PREA 3P5VA 2NQIA 2J7QC 2F7DA 4YYWA
chains in the Genus database with same CATH topology
4OVZA 4RF0A 4R3DA 4OW0A 1DKIA 4ZTBA 2BTWB 5KO3A 3PRPA 2Z84A 3ZNHA 4BOUA 4BOPA 2AGAA 5E6JA 3O65A 3IFUA 4BOZA 4MI7A 3E9SA 5JZEA 4D8EA 4M0WA 3BB7A 3BBAA 4BOQA 1PVJA 3C0RA 2JTCA 3PSEA 4MM3B 4RKXA 4GUAA 4P16A 4RF1A 3PHXA 3TMPA 5EZSA 4OVZB 2J7QA 2JRIA 4IP3A 4D8BA 2DOSA 4PT5A 4D8IA 3TRKA 4REZA 3PHUA 4BOSA 4IUMA 3B21A 2BU3A 5EZQA 2HWKA 4WURA 3PRMA 4XZXA 4HXDB 2UZJA 4RNAA 3BY4A 2FE8A 3PT2A 3MTVA 3W30A 3RNVA 3MJ5A 3W31A 1YZBA 1UKFA 3PHWA 3OQCA 3MP2A 4A5UA 2J7QC 2BTWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PRM A;  3PSE A;  3BY4 A;  3PRP A;  3PHU A;  4HXD B;  3PHX A;  4BOS A;  3ZNH A;  4BOZ A;  3PT2 A;  3TMP A;  4BOQ A;  4BOU A;  3C0R A;  5JZE A;  4BOP A;  3PHW A; 
#chains in the Genus database with same CATH topology
 1VJV A;  3N3G A;  4Q8H A;  3KFQ A;  4W5B A;  5CVO B;  4OVZ A;  2AYO A;  3P5X A;  2AS8 A;  1PIP A;  3IEJ A;  3KX1 A;  2NQD B;  1A6R A;  5CHV A;  1CS8 A;  5KO3 A;  1ICF A;  1GCB A;  1NQC A;  1U5I A;  3OF8 A;  3O65 A;  1ATK A;  2R9M A;  8PCH A;  5JZE A;  1PPD A;  3DF0 A;  4M0W A;  4BOQ A;  3RVV A;  3O1G A;  2FT2 A;  1U9V A;  4FJC A;  1MIR A;  3N4C A;  4RKX A;  2BDZ A;  1AU0 A;  4HWY A;  4X6J A;  4BPV A;  1ZCM A;  3CBK A;  3MOR A;  4D8B A;  3S3Q A;  2DOS A;  1KFX L;  1PCI A;  1U9Q X;  4D8I A;  2GFO A;  1CQD A;  5J94 A;  1U9X A;  3MHS A;  1GEC E;  1SP4 B;  4YYU A;  2YJ2 A;  4IUM A;  1PAD A;  2B1M A;  1VSN A;  1NB3 A;  3CH3 X;  4I07 A;  2E01 A;  3K9M A;  3WXG A;  1AU4 A;  1PPO A;  2AU1 A;  2AIM A;  3QJ3 A;  4PI3 A;  4K7C A;  2UZJ A;  4YV8 A;  4DMY A;  4CDC B;  4QH6 A;  4RNA A;  3ZUA A;  1TLO A;  2Y5B A;  1GLO A;  1CTE A;  2F1G A;  3RNV A;  3IOQ A;  1ME4 A;  4FIP A;  3W31 A;  1K3B B;  3E1Z B;  3BOW A;  5CHT A;  1YZB A;  1NLJ A;  2YJB A;  4QBB A;  4CZW A;  3CBJ A;  4W4U A;  2G6D A;  2JQG R;  3I3T A;  3PHW A;  5CVM A;  4BS6 A;  1NPZ A;  1AIM A;  5PAD A;  3MP2 A;  4X6H A;  4A5U A;  1Y08 A;  4N4Z A;  2FRA A;  2YJC A;  1YVB A;  1U9W A;  2VHF A;  3GCB A;  3U8E A;  1PPN A;  4CDE B;  2AUX A;  1MEG A;  4BOZ A;  4AXL A;  3E9S A;  2AVW A;  2DCB A;  1TU6 A;  4PP2 E;  2NQG A;  3QT4 A;  4I05 A;  2ARY A;  1AYV A;  2JTC A;  3PSE A;  1TL9 A;  3LXS A;  2P0R A;  3CH2 X;  1AU2 A;  1MEM A;  4RF1 A;  2YJ9 A;  3PHX A;  4XUI A;  4QRG A;  3TMP A;  4OVZ B;  1NL6 A;  1MS6 A;  3ERV A;  3OVZ A;  2J7Q A;  4IP3 A;  3WXF A;  1CV8 A;  2FTD A;  3MTN A;  1AU3 A;  2B1N A;  2OZ2 A;  4YYV A;  1PE6 A;  1FH0 A;  4REZ A;  1QOL A;  1BY8 A;  4KLB A;  2ATO A;  1QDQ A;  4WA6 A;  2IBI A;  3OF9 A;  4XZX A;  3PBH A;  1YK7 A;  4X6I A;  2PBH A;  4YYS A;  4YVA A;  3BY4 A;  5CVN B;  4QRX A;  2E00 A;  2FE8 A;  2XU1 A;  3PT2 A;  3PDF A;  2DC6 A;  2DCC A;  2DC7 A;  3HD3 A;  3B79 A;  2H7J A;  5F02 A;  3H8B A;  2GHU A;  4FK5 A;  1Q6K A;  4N79 A;  3PNR A;  1MDW A;  2O6X A;  3P5U A;  4N8W A;  1EWP A;  4RY2 A;  2BTW A;  3NHE A;  2FRQ A;  4DMX A;  4R3D A;  4OW0 A;  2AUZ A;  1DKI A;  2BTW B;  3PRP A;  2Z84 A;  1ZIV A;  2AGA A;  5E6J A;  2R9N A;  4BQV A;  4ZUX U;  2DZZ A;  1QXP A;  2DCD A;  2E02 A;  2PNS A;  3BB7 A;  4BSQ A;  1PVJ A;  4QRV A;  1EWM A;  2JQF R;  1AYW A;  3F5V A;  2YJ8 A;  3IMA A;  3IUT A;  4GUA A;  4P16 A;  1YAL A;  2DCA A;  1XKG A;  1THE A;  2R9O A;  3IHP A;  4P6G A;  4PT5 A;  3KKU A;  1JQP A;  3V6E A;  3WXE A;  4XR7 A;  2R9F A;  2HHN A;  3PHU A;  2P7U A;  3KWZ A;  3B21 A;  3M99 A;  9PAP A;  5EZQ A;  2HWK A;  4WUR A;  4MZO A;  4PAD A;  2CIO A;  3HHA A;  3K24 A;  3IV2 A;  6PAD A;  2XU3 A;  4YYR A;  4HXD B;  3H6S A;  1QMY A;  7PCK A;  4W5C A;  1IWD A;  1ITO A;  3BPF A;  3RVW A;  3S3R A;  2BDL A;  1BP4 A;  3MJ5 A;  1YK8 A;  2FO5 A;  2OP3 A;  1F2C A;  1KXR A;  2FYE A;  2E03 A;  2R9C A;  1M6D A;  3LFY A;  5JA7 A;  1O0E A;  2HD5 A;  3C9E A;  2FQ9 A;  1POP A;  3OQC A;  4CDD B;  2DC8 A;  1STF E;  1NB5 A;  1PBH A;  3OIS A;  1EWO A;  1YT7 A;  1F29 A;  2AYN A;  2XU5 A;  1F2B A;  2HXZ A;  3O0U A;  4RF0 A;  1CVZ A;  3RVX A;  3TNX A;  2DJF B;  2DJG B;  3V6C A;  2CB5 A;  4ZTB A;  1KFU L;  1DEU A;  3H8C A;  3ZNH A;  4BOU A;  4PP1 A;  3PW3 A;  4BOP A;  1EF7 A;  1CB5 A;  4OEL A;  3IFU A;  3HWN A;  3BWK A;  4MI7 A;  2P86 A;  4D8E A;  2VHS A;  1CJL A;  2G8J A;  3I06 A;  3BBA A;  4G54 A;  1AYU A;  3C0R A;  2NQA A;  5K16 A;  4MM3 B;  2PAD A;  3P5W A;  2XU4 A;  2Y6E A;  4Q8G A;  4OEM A;  5EZS A;  1CSB B;  3H7D A;  2ACT A;  2DC9 A;  2HH5 A;  2JRI A;  1CPJ A;  2IPP B;  2WBF X;  3KWB X;  3AI8 A;  3QSD A;  3USV A;  3KW9 A;  2DZY A;  3BC3 A;  1X9Y A;  4BS5 A;  3KSE A;  4YYQ A;  3TRK A;  4BOS A;  3HHI A;  4AXM A;  4CDF B;  4MZS A;  1AEC A;  2BU3 A;  2OUL A;  3K8U A;  4I04 A;  3D6S A;  2C0Y A;  1HUC B;  3PRM A;  5FPW A;  5A24 A;  1PPP A;  4MSX A;  1DF0 A;  1GMY A;  1Y4H A;  1MHW A;  2G8E A;  2G7Y A;  1SNK A;  1BQI A;  5EGW A;  3MTV A;  3W30 A;  1KHP A;  3H89 A;  1F2A A;  3OVX A;  3F75 A;  5JH3 A;  1UKF A;  3N3K A;  2FUD A;  1BGO A;  1S4V A;  1PXV A;  3BPM A;  1EWL A;  1ME3 A;  4P6E A;  5EF4 A;  3BCN A;  1KHQ A;  2R6N A;  3MHH A;  2PRE A;  3P5V A;  2NQI A;  2J7Q C;  2F7D A;  4YYW A; 
#chains in the Genus database with same CATH homology
 4OVZ A;  4RF0 A;  4R3D A;  4OW0 A;  1DKI A;  4ZTB A;  2BTW B;  5KO3 A;  3PRP A;  2Z84 A;  3ZNH A;  4BOU A;  4BOP A;  2AGA A;  5E6J A;  3O65 A;  3IFU A;  4BOZ A;  4MI7 A;  3E9S A;  5JZE A;  4D8E A;  4M0W A;  3BB7 A;  3BBA A;  4BOQ A;  1PVJ A;  3C0R A;  2JTC A;  3PSE A;  4MM3 B;  4RKX A;  4GUA A;  4P16 A;  4RF1 A;  3PHX A;  3TMP A;  5EZS A;  4OVZ B;  2J7Q A;  2JRI A;  4IP3 A;  4D8B A;  2DOS A;  4PT5 A;  4D8I A;  3TRK A;  4REZ A;  3PHU A;  4BOS A;  4IUM A;  3B21 A;  2BU3 A;  5EZQ A;  2HWK A;  4WUR A;  3PRM A;  4XZX A;  4HXD B;  2UZJ A;  4RNA A;  3BY4 A;  2FE8 A;  3PT2 A;  3MTV A;  3W30 A;  3RNV A;  3MJ5 A;  3W31 A;  1YZB A;  1UKF A;  3PHW A;  3OQC A;  3MP2 A;  4A5U A;  2J7Q C;  2BTW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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