3PHXA

Otu domain of crimean congo hemorrhagic fever virus in complex with isg15
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
164
structure length
162
Chain Sequence
GPMDFLRSLDWTQVIAGQYVSNPRFNISDYFEIVRQPGDGNCFYHSIAELTMPNKTDHSYHYIKRLTESAARKYYQEEPEARLVGLSLEDYLKRMLSDNEWGSTLEASMLAKEMGITIIIWTVSDEVEAGIKFGDGDVFTAVNLLHSGQTHFDALRILPQFE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
pubmed doi rcsb
molecule tags Hydrolase/protein binding
source organism Crimean-congo hemorrhagic fever virus
molecule keywords RNA-directed RNA polymerase L
total genus 48
structure length 162
sequence length 164
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2010-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02338 OTU OTU-like cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.80 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 3phxA00
3TMPA 3PRPA 3PT2A 4BOPA 4BOUA 4BOZA 5JZEA 3PHUA 3BY4A 3PRMA 4BOSA 4BOQA 3PHWA 3C0RA 3PSEA 4HXDB 3PHXA 3ZNHA
chains in the Genus database with same CATH superfamily
3S3RA 2YJ9A 3HWNA 4YYQA 2WBFX 4ZUXU 2JTCA 1ZIVA 1MHWA 4BOUA 3RVVA 2IBIA 4FJCA 3PNRA 1EWMA 2B1MA 2BU3A 3KFQA 2DC6A 3PHWA 1Q6KA 4OEMA 1SP4B 1F2CA 3PBHA 3O0UA 4XR7A 2DCAA 1PPPA 1CVZA 1QXPA 1EF7A 4CDDB 2E00A 2DOSA 3N3GA 3KWBX 7PCKA 2PNSA 1MEMA 1CTEA 4P6GA 4BOZA 4PT5A 5A24A 2JRIA 3F75A 1AU4A 3KW9A 2G6DA 4HXDB 1DKIA 3NHEA 4M0WA 5JZEA 3BOWA 3I3TA 2HXZA 4I05A 2GHUA 4CZWA 2ARYA 3RVXA 4PADA 2XU5A 2JQGR 1PE6A 1AIMA 2G8JA 3MORA 4I07A 1CSBB 1A6RA 1YVBA 3CBJA 4Q8GA 1PPOA 3P5VA 3H7DA 5JA7A 3B79A 2OULA 1O0EA 1TU6A 4OVZA 5CVOB 4YYRA 1NLJA 1MDWA 2G8EA 1NQCA 2BTWB 2C0YA 4FK5A 1KHPA 3PRMA 1GMYA 3USVA 3OF9A 2XU1A 4QRXA 1SNKA 2R9FA 4I04A 3OQCA 2YJCA 2P0RA 3BC3A 1KHQA 3P5XA 2R9MA 1HUCB 1BP4A 1K3BB 4QRGA 5EZSA 2J7QA 4HWYA 3IOQA 1YK8A 3PHUA 1CS8A 1CB5A 1NL6A 3BPFA 4X6JA 1F2BA 1PBHA 3V6EA 3H8CA 5CHTA 2XU4A 4G54A 4MM3B 3P5WA 4W5BA 2DJFB 2AVWA 1CJLA 5EF4A 2DZYA 1JQPA 4IP3A 4R3DA 2AYOA 1PCIA 3CH3X 2FT2A 2CIOA 4P16A 4D8IA 4QRVA 1CPJA 3N4CA 1ME3A 2F7DA 4N8WA 2F1GA 1QMYA 4IUMA 3K24A 3ZNHA 2Z84A 4OW0A 1Y4HA 4XZXA 3PSEA 3HHIA 1F29A 3GCBA 6PADA 3PT2A 3ERVA 3K8UA 4AXLA 4BS6A 3KX1A 4CDFB 2E02A 4GUAA 1MIRA 1ATKA 2H7JA 2E03A 4WA6A 1YALA 4YV8A 3IHPA 4W4UA 1YK7A 2AIMA 3K9MA 1ME4A 3D6SA 1BY8A 3PHXA 1QDQA 2ACTA 1NPZA 4RKXA 2VHSA 3ZUAA 3C9EA 2XU3A 4XUIA 2P86A 1U5IA 2DCBA 8PCHA 1YT7A 3BCNA 3KSEA 3H8BA 3H6SA 3CBKA 3OVXA 4REZA 3QSDA 3IEJA 1F2AA 2OP3A 1QOLA 2R9CA 4OELA 3V6CA 4D8BA 2AU1A 3OF8A 1VJVA 4BOPA 4YYUA 1U9XA 1AU3A 2YJBA 2BTWA 2FRQA 3KKUA 4OVZB 3E9SA 3MJ5A 4A5UA 5EZQA 2FO5A 3E1ZB 2R6NA 1STFE 1PVJA 3MTNA 3DF0A 3PRPA 1PPNA 2AUZA 2FRAA 1NB5A 1BQIA 3AI8A 1ITOA 2PREA 1YZBA 4DMXA 5FPWA 5EGWA 2Y5BA 4AXMA 1XKGA 5CVMA 1U9WA 1CV8A 2O6XA 1GECE 1S4VA 4DMYA 3P5UA 1X9YA 1PIPA 3B21A 3HD3A 3O1GA 3RVWA 5J94A 4D8EA 2PADA 3TNXA 1THEA 1PXVA 4RF1A 3MHSA 3TRKA 2YJ8A 3LXSA 4BQVA 5CHVA 2DC7A 3HHAA 3IV2A 2J7QC 3KWZA 4MZSA 1PADA 3M99A 2HH5A 1MEGA 4BOSA 1GLOA 2PBHA 2HWKA 4PP2E 3WXFA 3RNVA 2NQDB 1ICFA 4X6IA 3C0RA 4PP1A 9PAPA 2OZ2A 2R9NA 2DCDA 1NB3A 4N79A 1GCBA 3O65A 4YYVA 4RF0A 3BPMA 3MHHA 2NQGA 4K7CA 1PPDA 2UZJA 3CH2X 1AECA 3IFUA 1MS6A 2DZZA 1POPA 1U9QX 4PI3A 4BPVA 4YYSA 2AUXA 2P7UA 1UKFA 1FH0A 3W30A 3BB7A 3LFYA 1VSNA 3S3QA 3BWKA 3N3KA 1BGOA 1AU0A 2HD5A 2BDZA 2B1NA 2BDLA 4RY2A 2DC8A 3PDFA 2AS8A 4Q8HA 3MTVA 3OVZA 4BS5A 2NQIA 4KLBA 3I06A 1AYUA 2R9OA 4YVAA 3U8EA 2HHNA 2DJGB 1AYVA 3TMPA 1AU2A 4BOQA 1DF0A 5CVNB 5F02A 3WXGA 2FQ9A 1U9VA 2AGAA 3PW3A 2E01A 2DCCA 2G7YA 1EWPA 3W31A 4MI7A 5K16A 5E6JA 1DEUA 1AYWA 2CB5A 4QH6A 4N4ZA 2FUDA 1TL9A 2FTDA 2GFOA 2AYNA 1KXRA 2Y6EA 4ZTBA 4MSXA 2FYEA 5PADA 2FE8A 3F5VA 2DC9A 2ATOA 3MP2A 1KFUL 4CDEB 4RNAA 1ZCMA 2YJ2A 5KO3A 3WXEA 1KFXL 1EWLA 3QJ3A 1IWDA 3OISA 1EWOA 1CQDA 3BY4A 4BSQA 3BBAA 2IPPB 3QT4A 4FIPA 4W5CA 2NQAA 3IMAA 2JQFR 4QBBA 3IUTA 4P6EA 4YYWA 5JH3A 4X6HA 1M6DA 1Y08A 4MZOA 3H89A 4CDCB 2VHFA 4WURA 1TLOA
chains in the Genus database with same CATH topology
3BB7A 4D8BA 5EZSA 2J7QA 2JTCA 4BOPA 4BOUA 3PHUA 2BU3A 2BTWA 4OVZB 3E9SA 3MTVA 3MJ5A 3PHWA 4MM3B 4A5UA 5EZQA 1PVJA 4IP3A 3TMPA 3PRPA 4R3DA 4BOQA 1YZBA 2DOSA 4P16A 4D8IA 2AGAA 4BOZA 4PT5A 3B21A 4IUMA 3W31A 4MI7A 3ZNHA 5E6JA 2Z84A 4OW0A 2JRIA 4D8EA 4XZXA 3PSEA 4HXDB 1DKIA 4RF1A 3PT2A 4M0WA 5JZEA 3TRKA 4GUAA 4ZTBA 2J7QC 2FE8A 3MP2A 4BOSA 2HWKA 4RNAA 3RNVA 5KO3A 3C0RA 4OVZA 3PHXA 3BY4A 4RKXA 3BBAA 2BTWB 3O65A 3PRMA 4RF0A 2UZJA 3IFUA 3OQCA 4REZA 1UKFA 3W30A 4WURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TMP A;  3PRP A;  3PT2 A;  4BOP A;  4BOU A;  4BOZ A;  5JZE A;  3PHU A;  3BY4 A;  3PRM A;  4BOS A;  4BOQ A;  3PHW A;  3C0R A;  3PSE A;  4HXD B;  3PHX A;  3ZNH A; 
#chains in the Genus database with same CATH topology
 3S3R A;  2YJ9 A;  3HWN A;  4YYQ A;  2WBF X;  4ZUX U;  2JTC A;  1ZIV A;  1MHW A;  4BOU A;  3RVV A;  2IBI A;  4FJC A;  3PNR A;  1EWM A;  2B1M A;  2BU3 A;  3KFQ A;  2DC6 A;  3PHW A;  1Q6K A;  4OEM A;  1SP4 B;  1F2C A;  3PBH A;  3O0U A;  4XR7 A;  2DCA A;  1PPP A;  1CVZ A;  1QXP A;  1EF7 A;  4CDD B;  2E00 A;  2DOS A;  3N3G A;  3KWB X;  7PCK A;  2PNS A;  1MEM A;  1CTE A;  4P6G A;  4BOZ A;  4PT5 A;  5A24 A;  2JRI A;  3F75 A;  1AU4 A;  3KW9 A;  2G6D A;  4HXD B;  1DKI A;  3NHE A;  4M0W A;  5JZE A;  3BOW A;  3I3T A;  2HXZ A;  4I05 A;  2GHU A;  4CZW A;  2ARY A;  3RVX A;  4PAD A;  2XU5 A;  2JQG R;  1PE6 A;  1AIM A;  2G8J A;  3MOR A;  4I07 A;  1CSB B;  1A6R A;  1YVB A;  3CBJ A;  4Q8G A;  1PPO A;  3P5V A;  3H7D A;  5JA7 A;  3B79 A;  2OUL A;  1O0E A;  1TU6 A;  4OVZ A;  5CVO B;  4YYR A;  1NLJ A;  1MDW A;  2G8E A;  1NQC A;  2BTW B;  2C0Y A;  4FK5 A;  1KHP A;  3PRM A;  1GMY A;  3USV A;  3OF9 A;  2XU1 A;  4QRX A;  1SNK A;  2R9F A;  4I04 A;  3OQC A;  2YJC A;  2P0R A;  3BC3 A;  1KHQ A;  3P5X A;  2R9M A;  1HUC B;  1BP4 A;  1K3B B;  4QRG A;  5EZS A;  2J7Q A;  4HWY A;  3IOQ A;  1YK8 A;  3PHU A;  1CS8 A;  1CB5 A;  1NL6 A;  3BPF A;  4X6J A;  1F2B A;  1PBH A;  3V6E A;  3H8C A;  5CHT A;  2XU4 A;  4G54 A;  4MM3 B;  3P5W A;  4W5B A;  2DJF B;  2AVW A;  1CJL A;  5EF4 A;  2DZY A;  1JQP A;  4IP3 A;  4R3D A;  2AYO A;  1PCI A;  3CH3 X;  2FT2 A;  2CIO A;  4P16 A;  4D8I A;  4QRV A;  1CPJ A;  3N4C A;  1ME3 A;  2F7D A;  4N8W A;  2F1G A;  1QMY A;  4IUM A;  3K24 A;  3ZNH A;  2Z84 A;  4OW0 A;  1Y4H A;  4XZX A;  3PSE A;  3HHI A;  1F29 A;  3GCB A;  6PAD A;  3PT2 A;  3ERV A;  3K8U A;  4AXL A;  4BS6 A;  3KX1 A;  4CDF B;  2E02 A;  4GUA A;  1MIR A;  1ATK A;  2H7J A;  2E03 A;  4WA6 A;  1YAL A;  4YV8 A;  3IHP A;  4W4U A;  1YK7 A;  2AIM A;  3K9M A;  1ME4 A;  3D6S A;  1BY8 A;  3PHX A;  1QDQ A;  2ACT A;  1NPZ A;  4RKX A;  2VHS A;  3ZUA A;  3C9E A;  2XU3 A;  4XUI A;  2P86 A;  1U5I A;  2DCB A;  8PCH A;  1YT7 A;  3BCN A;  3KSE A;  3H8B A;  3H6S A;  3CBK A;  3OVX A;  4REZ A;  3QSD A;  3IEJ A;  1F2A A;  2OP3 A;  1QOL A;  2R9C A;  4OEL A;  3V6C A;  4D8B A;  2AU1 A;  3OF8 A;  1VJV A;  4BOP A;  4YYU A;  1U9X A;  1AU3 A;  2YJB A;  2BTW A;  2FRQ A;  3KKU A;  4OVZ B;  3E9S A;  3MJ5 A;  4A5U A;  5EZQ A;  2FO5 A;  3E1Z B;  2R6N A;  1STF E;  1PVJ A;  3MTN A;  3DF0 A;  3PRP A;  1PPN A;  2AUZ A;  2FRA A;  1NB5 A;  1BQI A;  3AI8 A;  1ITO A;  2PRE A;  1YZB A;  4DMX A;  5FPW A;  5EGW A;  2Y5B A;  4AXM A;  1XKG A;  5CVM A;  1U9W A;  1CV8 A;  2O6X A;  1GEC E;  1S4V A;  4DMY A;  3P5U A;  1X9Y A;  1PIP A;  3B21 A;  3HD3 A;  3O1G A;  3RVW A;  5J94 A;  4D8E A;  2PAD A;  3TNX A;  1THE A;  1PXV A;  4RF1 A;  3MHS A;  3TRK A;  2YJ8 A;  3LXS A;  4BQV A;  5CHV A;  2DC7 A;  3HHA A;  3IV2 A;  2J7Q C;  3KWZ A;  4MZS A;  1PAD A;  3M99 A;  2HH5 A;  1MEG A;  4BOS A;  1GLO A;  2PBH A;  2HWK A;  4PP2 E;  3WXF A;  3RNV A;  2NQD B;  1ICF A;  4X6I A;  3C0R A;  4PP1 A;  9PAP A;  2OZ2 A;  2R9N A;  2DCD A;  1NB3 A;  4N79 A;  1GCB A;  3O65 A;  4YYV A;  4RF0 A;  3BPM A;  3MHH A;  2NQG A;  4K7C A;  1PPD A;  2UZJ A;  3CH2 X;  1AEC A;  3IFU A;  1MS6 A;  2DZZ A;  1POP A;  1U9Q X;  4PI3 A;  4BPV A;  4YYS A;  2AUX A;  2P7U A;  1UKF A;  1FH0 A;  3W30 A;  3BB7 A;  3LFY A;  1VSN A;  3S3Q A;  3BWK A;  3N3K A;  1BGO A;  1AU0 A;  2HD5 A;  2BDZ A;  2B1N A;  2BDL A;  4RY2 A;  2DC8 A;  3PDF A;  2AS8 A;  4Q8H A;  3MTV A;  3OVZ A;  4BS5 A;  2NQI A;  4KLB A;  3I06 A;  1AYU A;  2R9O A;  4YVA A;  3U8E A;  2HHN A;  2DJG B;  1AYV A;  3TMP A;  1AU2 A;  4BOQ A;  1DF0 A;  5CVN B;  5F02 A;  3WXG A;  2FQ9 A;  1U9V A;  2AGA A;  3PW3 A;  2E01 A;  2DCC A;  2G7Y A;  1EWP A;  3W31 A;  4MI7 A;  5K16 A;  5E6J A;  1DEU A;  1AYW A;  2CB5 A;  4QH6 A;  4N4Z A;  2FUD A;  1TL9 A;  2FTD A;  2GFO A;  2AYN A;  1KXR A;  2Y6E A;  4ZTB A;  4MSX A;  2FYE A;  5PAD A;  2FE8 A;  3F5V A;  2DC9 A;  2ATO A;  3MP2 A;  1KFU L;  4CDE B;  4RNA A;  1ZCM A;  2YJ2 A;  5KO3 A;  3WXE A;  1KFX L;  1EWL A;  3QJ3 A;  1IWD A;  3OIS A;  1EWO A;  1CQD A;  3BY4 A;  4BSQ A;  3BBA A;  2IPP B;  3QT4 A;  4FIP A;  4W5C A;  2NQA A;  3IMA A;  2JQF R;  4QBB A;  3IUT A;  4P6E A;  4YYW A;  5JH3 A;  4X6H A;  1M6D A;  1Y08 A;  4MZO A;  3H89 A;  4CDC B;  2VHF A;  4WUR A;  1TLO A; 
#chains in the Genus database with same CATH homology
 3BB7 A;  4D8B A;  5EZS A;  2J7Q A;  2JTC A;  4BOP A;  4BOU A;  3PHU A;  2BU3 A;  2BTW A;  4OVZ B;  3E9S A;  3MTV A;  3MJ5 A;  3PHW A;  4MM3 B;  4A5U A;  5EZQ A;  1PVJ A;  4IP3 A;  3TMP A;  3PRP A;  4R3D A;  4BOQ A;  1YZB A;  2DOS A;  4P16 A;  4D8I A;  2AGA A;  4BOZ A;  4PT5 A;  3B21 A;  4IUM A;  3W31 A;  4MI7 A;  3ZNH A;  5E6J A;  2Z84 A;  4OW0 A;  2JRI A;  4D8E A;  4XZX A;  3PSE A;  4HXD B;  1DKI A;  4RF1 A;  3PT2 A;  4M0W A;  5JZE A;  3TRK A;  4GUA A;  4ZTB A;  2J7Q C;  2FE8 A;  3MP2 A;  4BOS A;  2HWK A;  4RNA A;  3RNV A;  5KO3 A;  3C0R A;  4OVZ A;  3PHX A;  3BY4 A;  4RKX A;  3BBA A;  2BTW B;  3O65 A;  3PRM A;  4RF0 A;  2UZJ A;  3IFU A;  3OQC A;  4REZ A;  1UKF A;  3W30 A;  4WUR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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