3TMPA

The catalytic domain of human deubiquitinase duba in complex with ubiquitin aldehyde
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
169
structure length
165
Chain Sequence
AGYNEDEYEAAAARIDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTGTSAVEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Phosphorylation-dependent activity of the deubiquitinase DUBA.
pubmed doi rcsb
molecule tags Hydrolase/protein binding
source organism Homo sapiens
molecule keywords OTU domain-containing protein 5
total genus 57
structure length 165
sequence length 169
chains with identical sequence C, E, G
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2011-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02338 OTU OTU-like cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.80 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 3tmpA01
3BY4A 3PHWA 3PHUA 3PT2A 5JZEA 3C0RA 3PSEA 4BOUA 4BOPA 4BOZA 3PHXA 3PRPA 4HXDB 3ZNHA 3TMPA 3PRMA 4BOSA 4BOQA
chains in the Genus database with same CATH superfamily
1GCBA 4YYRA 3K8UA 4D8BA 1F2AA 2DCBA 4ZUXU 1EF7A 3USVA 1KFXL 1CB5A 4XUIA 2P86A 3MJ5A 3MHHA 2B1MA 4N4ZA 2FQ9A 2Y6EA 4MM3B 4QRGA 4FK5A 1MEMA 3PDFA 1Y4HA 3CBKA 6PADA 1DKIA 2FTDA 1CPJA 4IP3A 5CHTA 3W31A 4OELA 1VSNA 3F75A 4W5BA 2DC6A 3IMAA 3RVXA 1NB5A 2UZJA 2DC7A 4W4UA 1PCIA 5K16A 4D8EA 3BOWA 1U9XA 2BDLA 4P16A 1PVJA 3PRMA 1ME3A 4CDCB 3H8BA 2DOSA 1QOLA 2YJ8A 3OISA 1YT7A 1AU4A 4PADA 3KWZA 2DC8A 4CDDB 1UKFA 4FIPA 1AYUA 1BY8A 2DC9A 4P6GA 2JQGR 2AU1A 2PREA 4Q8HA 2AIMA 4D8IA 2XU1A 5EF4A 2CIOA 4CDEB 4WURA 3CH3X 3WXEA 3MP2A 3RNVA 1U9VA 3H89A 4X6IA 2FE8A 4OEMA 2F1GA 2OP3A 3BWKA 4R3DA 2DJGB 1AYWA 3MTNA 1KFUL 4I07A 2XU4A 3HHAA 4YVAA 4N79A 4BOUA 4MZOA 4REZA 3KSEA 4RNAA 2HH5A 2C0YA 1CQDA 3LXSA 4IUMA 3BCNA 1NLJA 5CVNB 1KHQA 1PIPA 2GFOA 3OVXA 2PADA 1XKGA 2GHUA 5JH3A 3ERVA 2XU3A 1POPA 5JA7A 1PADA 3HHIA 2CB5A 3MORA 2FYEA 1ATKA 1CVZA 2AGAA 1A6RA 4PT5A 1Y08A 1TLOA 3DF0A 1CJLA 4MZSA 1ZIVA 2G8JA 1M6DA 4QH6A 2JTCA 2YJBA 5PADA 3IV2A 2E00A 1AU0A 3QT4A 1JQPA 7PCKA 4RF1A 2B1NA 4YV8A 1F2BA 1EWLA 4BOZA 2DJFB 4BS6A 2HWKA 3CH2X 2FT2A 1PPOA 1X9YA 1MDWA 4I05A 1Q6KA 2AYOA 4CZWA 4P6EA 4MI7A 2R6NA 2VHFA 3PRPA 4DMXA 2AS8A 5F02A 1HUCB 1NL6A 1PPPA 3KW9A 5CVMA 3F5VA 4W5CA 1QDQA 2FO5A 4RF0A 3IOQA 3D6SA 1SNKA 1MEGA 2AUZA 2F7DA 3RVWA 3U8EA 8PCHA 1NPZA 3WXFA 5CVOB 3ZNHA 2P0RA 4PP2E 3O65A 2DZYA 4BPVA 1GECE 2HXZA 3P5UA 2G8EA 3OQCA 3CBJA 3P5WA 4I04A 3OVZA 3ZUAA 1NB3A 2R9OA 3H7DA 4FJCA 3S3RA 1CTEA 2NQGA 5KO3A 4GUAA 3H8CA 3N3GA 2AUXA 4HXDB 3N4CA 1STFE 4OVZA 4OVZB 2NQIA 2BTWA 2BTWB 3KX1A 3PHUA 1PBHA 4QRVA 1PPDA 1AECA 2J7QA 4BOQA 1SP4B 1U9QX 2FUDA 3IHPA 2JQFR 2ACTA 4YYUA 1ME4A 5JZEA 5FPWA 2G7YA 5CHVA 4K7CA 4X6JA 2BU3A 3HWNA 3S3QA 3TRKA 3V6EA 1EWOA 1CV8A 1PE6A 3TMPA 5EZQA 1THEA 1DF0A 4XR7A 4WA6A 3PW3A 4N8WA 4G54A 4BSQA 2H7JA 4YYQA 3QJ3A 4X6HA 2ATOA 1AIMA 3H6SA 3BPMA 4M0WA 2BDZA 3E1ZB 1S4VA 1ITOA 4DMYA 2E01A 1PXVA 2Y5BA 4QRXA 3C0RA 4BOPA 1VJVA 1KXRA 3B21A 1YALA 2VHSA 1MIRA 1QXPA 2PNSA 3HD3A 3V6CA 5E6JA 2JRIA 3AI8A 2J7QC 9PAPA 1U5IA 3I3TA 2R9NA 2DCCA 4RY2A 1EWPA 4YYVA 5EZSA 3WXGA 1AYVA 1F2CA 3RVVA 3GCBA 2WBFX 1TL9A 2Z84A 2R9FA 3W30A 3P5XA 4BQVA 1GMYA 3PBHA 3KKUA 1YK7A 2IBIA 3BB7A 2R9CA 3PHXA 3B79A 2YJ9A 1YVBA 3K24A 4XZXA 4MSXA 4PI3A 4YYSA 3IFUA 5J94A 1FH0A 3O0UA 1DEUA 4CDFB 4AXMA 3KWBX 3LFYA 3P5VA 4BS5A 1NQCA 1U9WA 2HHNA 1O0EA 2NQDB 1CSBB 1MS6A 1YZBA 3E9SA 2FRAA 1AU2A 2OULA 1IWDA 3NHEA 3IEJA 3IUTA 2ARYA 4OW0A 3QSDA 4HWYA 3KFQA 3BPFA 3TNXA 1F29A 4BOSA 3BY4A 2OZ2A 4YYWA 2PBHA 3K9MA 3MHSA 1KHPA 3N3KA 1CS8A 4ZTBA 1ICFA 2DZZA 2HD5A 4RKXA 3PSEA 2AVWA 1EWMA 2O6XA 2FRQA 2R9MA 4QBBA 2E02A 1TU6A 5A24A 2DCAA 3I06A 1PPNA 4Q8GA 2YJCA 3PT2A 5EGWA 4A5UA 1YK8A 4PP1A 2AYNA 1BP4A 3M99A 2NQAA 3PHWA 2YJ2A 2P7UA 4AXLA 1BGOA 3C9EA 2XU5A 1QMYA 3BC3A 3OF8A 1GLOA 1K3BB 2G6DA 4KLBA 3OF9A 3BBAA 1BQIA 1MHWA 1AU3A 1ZCMA 2IPPB 3MTVA 3O1GA 3PNRA 2E03A 2DCDA
chains in the Genus database with same CATH topology
4REZA 4D8BA 4XZXA 4RNAA 3MJ5A 5KO3A 4GUAA 4IUMA 4HXDB 4MM3B 3IFUA 4OVZA 4OVZB 2BTWA 2BTWB 3PHUA 1DKIA 2J7QA 4BOQA 4IP3A 3W31A 5JZEA 1YZBA 3E9SA 2AGAA 4PT5A 2BU3A 3TRKA 2UZJA 4OW0A 4D8EA 4P16A 1PVJA 3TMPA 2JTCA 3PRMA 5EZQA 2DOSA 4BOSA 3BY4A 4RF1A 4BOZA 2HWKA 4M0WA 4ZTBA 1UKFA 4RKXA 3C0RA 3PSEA 4BOPA 3B21A 4MI7A 3PRPA 4D8IA 5E6JA 3PT2A 4A5UA 2JRIA 4WURA 2J7QC 3MP2A 3RNVA 2FE8A 3PHWA 4RF0A 5EZSA 4R3DA 3ZNHA 2Z84A 3O65A 3W30A 3BBAA 3BB7A 3MTVA 4BOUA 3PHXA 3OQCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BY4 A;  3PHW A;  3PHU A;  3PT2 A;  5JZE A;  3C0R A;  3PSE A;  4BOU A;  4BOP A;  4BOZ A;  3PHX A;  3PRP A;  4HXD B;  3ZNH A;  3TMP A;  3PRM A;  4BOS A;  4BOQ A; 
#chains in the Genus database with same CATH topology
 1GCB A;  4YYR A;  3K8U A;  4D8B A;  1F2A A;  2DCB A;  4ZUX U;  1EF7 A;  3USV A;  1KFX L;  1CB5 A;  4XUI A;  2P86 A;  3MJ5 A;  3MHH A;  2B1M A;  4N4Z A;  2FQ9 A;  2Y6E A;  4MM3 B;  4QRG A;  4FK5 A;  1MEM A;  3PDF A;  1Y4H A;  3CBK A;  6PAD A;  1DKI A;  2FTD A;  1CPJ A;  4IP3 A;  5CHT A;  3W31 A;  4OEL A;  1VSN A;  3F75 A;  4W5B A;  2DC6 A;  3IMA A;  3RVX A;  1NB5 A;  2UZJ A;  2DC7 A;  4W4U A;  1PCI A;  5K16 A;  4D8E A;  3BOW A;  1U9X A;  2BDL A;  4P16 A;  1PVJ A;  3PRM A;  1ME3 A;  4CDC B;  3H8B A;  2DOS A;  1QOL A;  2YJ8 A;  3OIS A;  1YT7 A;  1AU4 A;  4PAD A;  3KWZ A;  2DC8 A;  4CDD B;  1UKF A;  4FIP A;  1AYU A;  1BY8 A;  2DC9 A;  4P6G A;  2JQG R;  2AU1 A;  2PRE A;  4Q8H A;  2AIM A;  4D8I A;  2XU1 A;  5EF4 A;  2CIO A;  4CDE B;  4WUR A;  3CH3 X;  3WXE A;  3MP2 A;  3RNV A;  1U9V A;  3H89 A;  4X6I A;  2FE8 A;  4OEM A;  2F1G A;  2OP3 A;  3BWK A;  4R3D A;  2DJG B;  1AYW A;  3MTN A;  1KFU L;  4I07 A;  2XU4 A;  3HHA A;  4YVA A;  4N79 A;  4BOU A;  4MZO A;  4REZ A;  3KSE A;  4RNA A;  2HH5 A;  2C0Y A;  1CQD A;  3LXS A;  4IUM A;  3BCN A;  1NLJ A;  5CVN B;  1KHQ A;  1PIP A;  2GFO A;  3OVX A;  2PAD A;  1XKG A;  2GHU A;  5JH3 A;  3ERV A;  2XU3 A;  1POP A;  5JA7 A;  1PAD A;  3HHI A;  2CB5 A;  3MOR A;  2FYE A;  1ATK A;  1CVZ A;  2AGA A;  1A6R A;  4PT5 A;  1Y08 A;  1TLO A;  3DF0 A;  1CJL A;  4MZS A;  1ZIV A;  2G8J A;  1M6D A;  4QH6 A;  2JTC A;  2YJB A;  5PAD A;  3IV2 A;  2E00 A;  1AU0 A;  3QT4 A;  1JQP A;  7PCK A;  4RF1 A;  2B1N A;  4YV8 A;  1F2B A;  1EWL A;  4BOZ A;  2DJF B;  4BS6 A;  2HWK A;  3CH2 X;  2FT2 A;  1PPO A;  1X9Y A;  1MDW A;  4I05 A;  1Q6K A;  2AYO A;  4CZW A;  4P6E A;  4MI7 A;  2R6N A;  2VHF A;  3PRP A;  4DMX A;  2AS8 A;  5F02 A;  1HUC B;  1NL6 A;  1PPP A;  3KW9 A;  5CVM A;  3F5V A;  4W5C A;  1QDQ A;  2FO5 A;  4RF0 A;  3IOQ A;  3D6S A;  1SNK A;  1MEG A;  2AUZ A;  2F7D A;  3RVW A;  3U8E A;  8PCH A;  1NPZ A;  3WXF A;  5CVO B;  3ZNH A;  2P0R A;  4PP2 E;  3O65 A;  2DZY A;  4BPV A;  1GEC E;  2HXZ A;  3P5U A;  2G8E A;  3OQC A;  3CBJ A;  3P5W A;  4I04 A;  3OVZ A;  3ZUA A;  1NB3 A;  2R9O A;  3H7D A;  4FJC A;  3S3R A;  1CTE A;  2NQG A;  5KO3 A;  4GUA A;  3H8C A;  3N3G A;  2AUX A;  4HXD B;  3N4C A;  1STF E;  4OVZ A;  4OVZ B;  2NQI A;  2BTW A;  2BTW B;  3KX1 A;  3PHU A;  1PBH A;  4QRV A;  1PPD A;  1AEC A;  2J7Q A;  4BOQ A;  1SP4 B;  1U9Q X;  2FUD A;  3IHP A;  2JQF R;  2ACT A;  4YYU A;  1ME4 A;  5JZE A;  5FPW A;  2G7Y A;  5CHV A;  4K7C A;  4X6J A;  2BU3 A;  3HWN A;  3S3Q A;  3TRK A;  3V6E A;  1EWO A;  1CV8 A;  1PE6 A;  3TMP A;  5EZQ A;  1THE A;  1DF0 A;  4XR7 A;  4WA6 A;  3PW3 A;  4N8W A;  4G54 A;  4BSQ A;  2H7J A;  4YYQ A;  3QJ3 A;  4X6H A;  2ATO A;  1AIM A;  3H6S A;  3BPM A;  4M0W A;  2BDZ A;  3E1Z B;  1S4V A;  1ITO A;  4DMY A;  2E01 A;  1PXV A;  2Y5B A;  4QRX A;  3C0R A;  4BOP A;  1VJV A;  1KXR A;  3B21 A;  1YAL A;  2VHS A;  1MIR A;  1QXP A;  2PNS A;  3HD3 A;  3V6C A;  5E6J A;  2JRI A;  3AI8 A;  2J7Q C;  9PAP A;  1U5I A;  3I3T A;  2R9N A;  2DCC A;  4RY2 A;  1EWP A;  4YYV A;  5EZS A;  3WXG A;  1AYV A;  1F2C A;  3RVV A;  3GCB A;  2WBF X;  1TL9 A;  2Z84 A;  2R9F A;  3W30 A;  3P5X A;  4BQV A;  1GMY A;  3PBH A;  3KKU A;  1YK7 A;  2IBI A;  3BB7 A;  2R9C A;  3PHX A;  3B79 A;  2YJ9 A;  1YVB A;  3K24 A;  4XZX A;  4MSX A;  4PI3 A;  4YYS A;  3IFU A;  5J94 A;  1FH0 A;  3O0U A;  1DEU A;  4CDF B;  4AXM A;  3KWB X;  3LFY A;  3P5V A;  4BS5 A;  1NQC A;  1U9W A;  2HHN A;  1O0E A;  2NQD B;  1CSB B;  1MS6 A;  1YZB A;  3E9S A;  2FRA A;  1AU2 A;  2OUL A;  1IWD A;  3NHE A;  3IEJ A;  3IUT A;  2ARY A;  4OW0 A;  3QSD A;  4HWY A;  3KFQ A;  3BPF A;  3TNX A;  1F29 A;  4BOS A;  3BY4 A;  2OZ2 A;  4YYW A;  2PBH A;  3K9M A;  3MHS A;  1KHP A;  3N3K A;  1CS8 A;  4ZTB A;  1ICF A;  2DZZ A;  2HD5 A;  4RKX A;  3PSE A;  2AVW A;  1EWM A;  2O6X A;  2FRQ A;  2R9M A;  4QBB A;  2E02 A;  1TU6 A;  5A24 A;  2DCA A;  3I06 A;  1PPN A;  4Q8G A;  2YJC A;  3PT2 A;  5EGW A;  4A5U A;  1YK8 A;  4PP1 A;  2AYN A;  1BP4 A;  3M99 A;  2NQA A;  3PHW A;  2YJ2 A;  2P7U A;  4AXL A;  1BGO A;  3C9E A;  2XU5 A;  1QMY A;  3BC3 A;  3OF8 A;  1GLO A;  1K3B B;  2G6D A;  4KLB A;  3OF9 A;  3BBA A;  1BQI A;  1MHW A;  1AU3 A;  1ZCM A;  2IPP B;  3MTV A;  3O1G A;  3PNR A;  2E03 A;  2DCD A; 
#chains in the Genus database with same CATH homology
 4REZ A;  4D8B A;  4XZX A;  4RNA A;  3MJ5 A;  5KO3 A;  4GUA A;  4IUM A;  4HXD B;  4MM3 B;  3IFU A;  4OVZ A;  4OVZ B;  2BTW A;  2BTW B;  3PHU A;  1DKI A;  2J7Q A;  4BOQ A;  4IP3 A;  3W31 A;  5JZE A;  1YZB A;  3E9S A;  2AGA A;  4PT5 A;  2BU3 A;  3TRK A;  2UZJ A;  4OW0 A;  4D8E A;  4P16 A;  1PVJ A;  3TMP A;  2JTC A;  3PRM A;  5EZQ A;  2DOS A;  4BOS A;  3BY4 A;  4RF1 A;  4BOZ A;  2HWK A;  4M0W A;  4ZTB A;  1UKF A;  4RKX A;  3C0R A;  3PSE A;  4BOP A;  3B21 A;  4MI7 A;  3PRP A;  4D8I A;  5E6J A;  3PT2 A;  4A5U A;  2JRI A;  4WUR A;  2J7Q C;  3MP2 A;  3RNV A;  2FE8 A;  3PHW A;  4RF0 A;  5EZS A;  4R3D A;  3ZNH A;  2Z84 A;  3O65 A;  3W30 A;  3BBA A;  3BB7 A;  3MTV A;  4BOU A;  3PHX A;  3OQC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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